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Aliases for TMSB15B Gene

Aliases for TMSB15B Gene

  • Thymosin Beta 15B 2 3 5
  • Tbeta15b 3

External Ids for TMSB15B Gene

Previous GeneCards Identifiers for TMSB15B Gene

  • GC0XP103104
  • GC0XP092867

Summaries for TMSB15B Gene

GeneCards Summary for TMSB15B Gene

TMSB15B (Thymosin Beta 15B) is a Protein Coding gene. GO annotations related to this gene include actin binding and actin monomer binding. An important paralog of this gene is ENSG00000269226.

UniProtKB/Swiss-Prot for TMSB15B Gene

  • Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity). May be involved in cell migration.

Gene Wiki entry for TMSB15B Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMSB15B Gene

Genomics for TMSB15B Gene

Regulatory Elements for TMSB15B Gene

Enhancers for TMSB15B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TMSB15B on UCSC Golden Path with GeneCards custom track

Promoters for TMSB15B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TMSB15B on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the TMSB15B gene promoter:

Genomic Location for TMSB15B Gene

103,918,896 bp from pter
103,966,712 bp from pter
47,817 bases
Plus strand

Genomic View for TMSB15B Gene

Genes around TMSB15B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMSB15B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMSB15B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMSB15B Gene

Proteins for TMSB15B Gene

  • Protein details for TMSB15B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Thymosin beta-15B
    Protein Accession:
    Secondary Accessions:
    • A8K614
    • Q99406

    Protein attributes for TMSB15B Gene

    45 amino acids
    Molecular mass:
    5229 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMSB15B Gene

Proteomics data for TMSB15B Gene at MOPED

Post-translational modifications for TMSB15B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMSB15B Gene

No data available for DME Specific Peptides for TMSB15B Gene

Domains & Families for TMSB15B Gene

Protein Domains for TMSB15B Gene


Suggested Antigen Peptide Sequences for TMSB15B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the thymosin beta family.
  • Belongs to the thymosin beta family.
genes like me logo Genes that share domains with TMSB15B: view

No data available for Gene Families for TMSB15B Gene

Function for TMSB15B Gene

Molecular function for TMSB15B Gene

UniProtKB/Swiss-Prot Function:
Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity). May be involved in cell migration.

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMSB15B Gene

Localization for TMSB15B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMSB15B Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

Jensen Localization Image for TMSB15B Gene COMPARTMENTS Subcellular localization image for TMSB15B gene
Compartment Confidence
cytoskeleton 3

Gene Ontology (GO) - Cellular Components for TMSB15B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with TMSB15B: view

Pathways & Interactions for TMSB15B Gene

SuperPathways for TMSB15B Gene

No Data Available

Interacting Proteins for TMSB15B Gene

Gene Ontology (GO) - Biological Process for TMSB15B Gene


No data available for Pathways by source and SIGNOR curated interactions for TMSB15B Gene

Drugs & Compounds for TMSB15B Gene

No Compound Related Data Available

Transcripts for TMSB15B Gene

Unigene Clusters for TMSB15B Gene

Thymosin beta 15B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMSB15B Gene

No ASD Table

Relevant External Links for TMSB15B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMSB15B Gene

mRNA expression in normal human tissues for TMSB15B Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for TMSB15B Gene

SOURCE GeneReport for Unigene cluster for TMSB15B Gene Hs.675540

mRNA Expression by UniProt/SwissProt for TMSB15B Gene

Tissue specificity: Expressed in colon and colon cancer tissue.
genes like me logo Genes that share expression patterns with TMSB15B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Protein tissue co-expression partners for TMSB15B Gene

Orthologs for TMSB15B Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMSB15B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TMSB4 36
  • 70 (a)
(Canis familiaris)
Mammalia -- 36
  • 42 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 68 (a)
(Mus musculus)
Mammalia Tmsb15b1 36
  • 80 (a)
Tmsb15b2 36
  • 46 (a)
Tmsb15l 36
  • 46 (a)
(Pan troglodytes)
Mammalia -- 36
  • 70 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 84 (a)
(Danio rerio)
Actinopterygii si:ch211-11c15.3 36
  • 62 (a)
tmsb 36
  • 53 (a)
tmsb4x 36
  • 66 (a)
Species with no ortholog for TMSB15B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMSB15B Gene

Gene Tree for TMSB15B (if available)
Gene Tree for TMSB15B (if available)

Paralogs for TMSB15B Gene

Paralogs for TMSB15B Gene

genes like me logo Genes that share paralogs with TMSB15B: view

Variants for TMSB15B Gene

Sequence variations from dbSNP and Humsavar for TMSB15B Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1180753 -- 103,964,431(+) GGGAT(C/T)GCGCC intron-variant
rs3752328 -- 103,962,767(+) GGGAC(G/T)GGAAG intron-variant
rs12858641 -- 103,963,879(+) TCTGG(G/T)CTTGT intron-variant
rs34464002 -- 103,960,807(+) TGGTG(-/T)CTAGT upstream-variant-2KB
rs35082450 -- 103,964,947(+) CATTT(-/A)AAAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMSB15B Gene

Variant ID Type Subtype PubMed ID
dgv2459e1 CNV Complex 17122850
nsv469772 CNV Complex 16826518
nsv519626 CNV Gain 19592680
nsv7453 OTHER Inversion 18451855
esv27035 CNV Gain 19812545
esv1007027 OTHER Inversion 20482838

Variation tolerance for TMSB15B Gene

Residual Variation Intolerance Score: 49.4% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TMSB15B Gene

Disorders for TMSB15B Gene

Relevant External Links for TMSB15B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TMSB15B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMSB15B Gene

Publications for TMSB15B Gene

  1. Differential regulation of human thymosin beta 15 isoforms by transforming growth factor beta 1. (PMID: 19296525) Banyard J. … Zetter B.R. (Genes Chromosomes Cancer 2009) 3 4 67
  2. Thymosin beta-NB is the human isoform of rat thymosin beta15. (PMID: 17567946) Banyard J. … Zetter B.R. (Ann. N. Y. Acad. Sci. 2007) 2 3
  3. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  5. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PMID: 12665801) Gevaert K. … Vandekerckhove J. (Nat. Biotechnol. 2003) 3

Products for TMSB15B Gene

Sources for TMSB15B Gene