TMSB15B Gene
protein-coding GIFtS: 35
GCID: GC0XP103104
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thymosin beta 15B
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Aliases
for TMSB15B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Thymosin Beta 15B1 2 | | MGC399001 | | Tbeta15b2 | | Thymosin Beta-15B2 |
Export aliases for TMSB15B gene to outside databasesPrevious GC identifer: GC0XP092867 |
Summaries
for TMSB15B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: TB15B_HUMAN, P0CG35Function: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (Gactin) and therefore inhibits actin polymerization (By similarity). May be involved in cell migration
Gene Wiki entry for TMSB15B
|
Genomic Views
for TMSB15B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_011651.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TMSB15B gene promoter:
Cart-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for TMSB15B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMSB15B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xq22.2 Ensembl cytogenetic band: Xq22.2 HGNC cytogenetic band: Xq22.2TMSB15B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP103104: view genomic region
(about GC identifiers)
Start:
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103,173,479 bp from pter |
End:
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103,229,570 bp from pter |
Size:
|
56,092 bases |
Orientation:
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plus strand |
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Proteins
for TMSB15B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TB15B_HUMAN, P0CG35 (See
protein sequence)Recommended Name: Thymosin beta-15B Size: 45 amino acids; 5229 Da
Subcellular location: Cytoplasm, cytoskeleton (By similarity)
Secondary accessions: A8K614 Q99406Explore the universe of human proteins at neXtProt for TMSB15B: NX_P0CG35
TMSB15B Protein expression data from MOPED and PaxDb: --
REFSEQ proteins: NP_919305.2
ENSEMBL proteins: ENSP00000456121 ENSP00000457524 ENSP00000455771 ENSP00000457601 ENSP00000457057 ENSP00000455371
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
TMSB15B for ontologies About GeneDecksing
TMSB15B Antibody Products:
Assay Products for TMSB15B: |
Protein
Domains /
Families
for TMSB15B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TMSB15B for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P0CG35ProtoNet protein and cluster: P0CG35 UniProtKB/Swiss-Prot: TB15B_HUMAN, P0CG35Similarity: Belongs to the thymosin beta family |
Function
for TMSB15B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TB15B_HUMAN, P0CG35Function: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (Gactin) and therefore inhibits actin polymerization (By similarity). May be involved in cell migration
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMSB15B
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMSB15B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003779 | actin binding |
IEA | -- |
TMSB15B for ontologies About GeneDecksing
|
Pathways & Interactions
for TMSB15B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMSB15B
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0030036 | actin cytoskeleton organization |
IEA | -- | | GO:0042989 | sequestering of actin monomers |
IEA | -- |
TMSB15B for ontologies About GeneDecksing
|
Drugs & Compounds
for TMSB15B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TMSB15B
Search CenterWatch for drugs/clinical trials and news about TMSB15B / TB15B
|
Transcripts
for TMSB15B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TMSB15B gene: NM_194324.2 Unigene Clusters for TMSB15B: Thymosin beta 15B Hs.675540 [show with all ESTs], Hs.709594 [show with all ESTs]Unigene Representative Sequences: AK090973, BM9035277 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000419165(uc004elo.4 uc010noz.3) ENST00000455723(uc004eln.1)
ENST00000563257 ENST00000436583(uc004elq.4) ENST00000567181 ENST00000569577
ENST00000540220
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMSB15B
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMSB15B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TMSB15B (NM_194324) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMSB15B | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TMSB15B |
Additional cDNA sequence: AK291479.1 BC019900.1 BC054476.1 BC093093.1 7 DOTS entries: DT.101981995 DT.100782452 DT.91949543 DT.85104304 DT.91682432 DT.433283 DT.121308162 24/83 AceView cDNA sequences (see all 83): BC019900 AA988577 AW137047 AA810624 H99198 BP431536 AA720588 N55323 AA287552 AW953509 AI458295 BC035660 CK300729 BI915613 AI493191 AI095785 BX280046 AI097145 W23770 BE619386 BX108941 BQ012063 AA884864 CB126583
GeneLoc Exon Structure
|
Expression
for TMSB15B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TMSB15B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAGTTGCATC
About this image
Genevestigator expression for TMSB15B
SOURCE GeneReport for Unigene clusters: Hs.675540 Hs.709594
UniProtKB/Swiss-Prot: TB15B_HUMAN, P0CG35Tissue specificity: Expressed in colon and colon cancer tissue
SABiosciences Custom PCR Arrays for TMSB15B
Primer
Products: | | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat TMSB15B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMSB15B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMSB15B |
Orthologs
for TMSB15B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for TMSB15B gene from 2/5 species (see all 5) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
TMSB15A6 |
-- |
71(a) |
1 → many |
GL343686.1(76446-76690) |
zebrafish
(Danio rerio) |
Actinopterygii |
zgc:1951546 |
zgc:195154 |
61(a) |
1 → many |
9(56198178-56199762) |
ENSEMBL Gene Tree for TMSB15B (if available)
TreeFam Gene Tree for TMSB15B (if available) |
Paralogs
for TMSB15B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TMSB15B gene
- TMSB15A2 TMSB4Y2 TMSB4XP42 TMSB4X2 TMSB102
18/34 SIMAP similar genes for TMSB15B using alignment to 3 protein entries: TB15B_HUMAN (see all proteins)
(see all similar genes):TMSB15A TMSB10 TMSB4X TMSB4XP4 TMSB4Y AARSD1
NF2 CATSPERG FOPNL FAM175A ZNF564 ATP6V0A1
FAM210A SHANK2 ERBB2 TSEN2 APOD AURA2
TMSB15B for paralogs About GeneDecksing
|
Genomic Variants
for TMSB15B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TMSB15B (103173479 - 103229570 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 8 variations for TMSB15B
6 CNVs: 96872 83662 4160 96870 52902 74033
2 Inversions: 37340 37341 | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for TMSB15B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TMSB15B for disorders About GeneDecksing
1  disease for TMSB15B: About MalaCardscolon cancer
Export disorders for TMSB15B gene to outside databases
|
Publications
for TMSB15B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TMSB15B gene integrated from 9 sources:
(articles sorted by number of sources associating them with TMSB15B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Differential regulation of human thymosin beta 15 isoforms by transforming growth factor beta 1. (PubMed id 19296525)1, 2 Banyard J....Zetter B.R. (2009)
- Thymosin beta-NB is the human isoform of rat thymosin beta15. (PubMed id 17567946)1, 3 Banyard J....Zetter B.R. (2007)
- The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for TMSB15B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TMSB15B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TMSB15B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TMSB15B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TMSB15B | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TMSB15B gene:
Search GeneIP for patents involving TMSB15B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TMSB15B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TMSB15B | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMSB15B | | Browse OriGene genome-wide validated SYBR primer pairs | | | OriGene Protein Over-expression Lysate for TMSB15B | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for TMSB15B | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMSB15B | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMSB15B | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TMSB15B | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMSB15B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMSB15B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMSB15B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMSB15B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMSB15B |
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 |  |  |  | |
| | | | Search Tocris compounds for TMSB15B |
| |  |  |  |  | | | | |
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 | | | | |  |  |  | | | | Search ThermoFisher Antibodies for TMSB15B |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TMSB15B |
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