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TMSB15B Gene

protein-coding   GIFtS: 31
GCID: GC0XP103104

Thymosin Beta 15B

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Thymosin Beta 15B1 2
Tbeta15b2
Thymosin Beta-15B2

External Ids:    HGNC: 286121   Entrez Gene: 2865272   Ensembl: ENSG000001584277   UniProtKB: P0CG353   

Export aliases for TMSB15B gene to outside databases

Previous GC identifer: GC0XP092867


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TMSB15B Gene:
TMSB15B (thymosin beta 15B) is a protein-coding gene. GO annotations related to this gene include actin binding. An important paralog of this gene is TMSB15A.

UniProtKB/Swiss-Prot: TB15B_HUMAN, P0CG35
Function: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers
(G actin) and therefore inhibits actin polymerization (By similarity). May be involved in cell migration

Gene Wiki entry for TMSB15B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the TMSB15B gene promoter:
         Cart-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for TMSB15B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TMSB15B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq22.2   Ensembl cytogenetic band:  Xq22.2   HGNC cytogenetic band: Xq22.2

TMSB15B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMSB15B gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP103104:  view genomic region     (about GC identifiers)

Start:
103,173,479 bp from pter      End:
103,229,570 bp from pter
Size:
56,092 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TB15B_HUMAN, P0CG35 (See protein sequence)
Recommended Name: Thymosin beta-15B  
Size: 45 amino acids; 5229 Da
Secondary accessions: A8K614 Q99406

Explore the universe of human proteins at neXtProt for TMSB15B: NX_P0CG35

Explore proteomics data for TMSB15B at MOPED


See TMSB15B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_919305.2  
ENSEMBL proteins: 
 ENSP00000456121   ENSP00000457524   ENSP00000455771   ENSP00000457601   ENSP00000457057  
 ENSP00000455371  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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2 InterPro protein domains:
 IPR001152 Thymosin_b4
 IPR016323 Thymosin_b4_metazoa

Graphical View of Domain Structure for InterPro Entry P0CG35

ProtoNet protein and cluster: P0CG35

UniProtKB/Swiss-Prot: TB15B_HUMAN, P0CG35
Similarity: Belongs to the thymosin beta family


Find genes that share domains with TMSB15B           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: TB15B_HUMAN, P0CG35
Function: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers
(G actin) and therefore inhibits actin polymerization (By similarity). May be involved in cell migration

     Gene Ontology (GO): 1 molecular function term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003779actin binding IEA--
     
Find genes that share ontologies with TMSB15B           About GenesLikeMe


Animal Models:
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
TB15B_HUMAN, P0CG35: Cytoplasm, cytoskeleton (By similarity)

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005737cytoplasm IEA--
GO:0005856cytoskeleton IEA--

Find genes that share ontologies with TMSB15B           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TMSB15B
Interactions:

    Search GeneGlobe Interaction Network for TMSB15B

Gene Ontology (GO): 3 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007010cytoskeleton organization ----
GO:0030036actin cytoskeleton organization IEA--
GO:0042989sequestering of actin monomers IEA--

Find genes that share ontologies with TMSB15B           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
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Browse Tocris compounds for TMSB15B (TB15B)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for TMSB15B gene: 
NM_194324.2  

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000419165(uc004elo.4 uc010noz.3) ENST00000455723(uc004eln.1)
ENST00000563257 ENST00000436583(uc004elq.4) ENST00000567181 ENST00000569577
ENST00000540220
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Selected AceView cDNA sequences (see all 83):

BI915613 BC035660 AI458295 AA720588 BP431536 AI095785 H99198 AI493191 
AA988577 AA810624 BX280046 AI097145 AA287552 AW137047 N55323 W23770 
CK300729 BC019900 AW953509 BQ233478 BI439595 BE888191 BQ011701 CB125425 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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TMSB15B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: AAGTTGCATC
TMSB15B Expression
About this image

TMSB15B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

TMSB15B Protein Expression

UniProtKB/Swiss-Prot: TB15B_HUMAN, P0CG35
Tissue specificity: Expressed in colon and colon cancer tissue

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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for TMSB15B gene from Selected species (see all 7)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
lizard
(Anolis carolinensis)
Reptilia --
Uncharacterized protein
84(a)
1 → many
GL343686.1(76431-76694)
zebrafish
(Danio rerio)
Actinopterygii tmsb4x6
si:ch211-11c15.36
(see all 3)
si:ch211-11c15.3
(see all 3)
66(a)
62(a)
(see all 3)
many ↔ many
many ↔ many
(see all 3)
9(56198178-56199762) ENSDARG00000077777
14(35617038-35619396) ENSDARG00000092970
        Species with no ortholog for TMSB15B

ENSEMBL Gene Tree for TMSB15B (if available)
TreeFam Gene Tree for TMSB15B (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for TMSB15B gene
TMSB15A2  TMSB4Y2  TMSB102  TMSB4X2  
Selected SIMAP similar genes for TMSB15B using alignment to 3 protein entries:     TB15B_HUMAN (see all proteins) (see all similar genes):
TMSB15A    TMSB10    TMSB4X    TMSB4XP4    TMSB4Y    AARSD1
NF2    CATSPERG    FOPNL    ADCK5    FAM175A    ZNF564
ASB11    ATP6V0A1    FAM210A    SHANK2    ZNF28    ERBB2

Find genes that share paralogs with TMSB15B           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for TMSB15B (see all 112)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr X posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1853446161,2
--92869747(-) TCATTC/GCTGCC 1 -- int10--------
rs1932422341,2
--92869844(-) GATCCC/TCTGAA 1 -- int10--------
rs1398171621,2
--92869922(-) ATAAAA/GCACAA 1 -- int10--------
rs1416266221,2
C--92870031(-) GCCAGC/TCACCA 1 -- int10--------
rs1880225751,2
--92870053(-) GATAAC/TATTTA 1 -- int10--------
rs1821867731,2
--92870084(-) TCTCCA/CTTGAA 1 -- int10--------
rs1915098571,2
--92870181(-) AAGCCA/TAAGAC 1 -- int10--------
rs1781081,2
C,F,A,H--92870204(+) CAAACA/GAGGCT 1 -- int116Minor allele frequency- G:0.42NS EA NA WA 1976
rs1434874341,2
--92870269(-) TCTGGC/TCTGTT 1 -- int10--------
rs1781071,2
C,F,A,H--92870301(+) agcagC/Ttagtg 1 -- int116Minor allele frequency- T:0.42NS EA NA WA 1958

HapMap Linkage Disequilibrium report for TMSB15B (103173479 - 103229570 bp)

Structural Variations
     Database of Genomic Variants (DGV) 6 variations for TMSB15B:    About this table    
Variant IDTypeSubtypePubMed ID
esv27035CNV Gain19812545
nsv519626CNV Gain19592680
nsv469772CNV Complex16826518
dgv2459e1CNV Complex17122850
esv1007027OTHER Inversion20482838
nsv7453OTHER Inversion18451855

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for TMSB15B gene integrated from 10 sources:
(articles sorted by number of sources associating them with TMSB15B)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Differential regulation of human thymosin beta 15 isoforms by transforming growth factor beta 1. (PubMed id 19296525)1, 2 Banyard J.... Zetter B.R. (Genes Chromosomes Cancer 2009)
  2. Thymosin beta-NB is the human isoform of rat thymosin beta15. (PubMed id 17567946)1, 3 Banyard J....Zetter B.R. (Ann. N. Y. Acad. Sci. 2007)
  3. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (Nature 2005)
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  5. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (Nat. Biotechnol. 2003)
  6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 286527 HGNC: 28612 AceView: MGC39900 Ensembl:ENSG00000158427 euGenes: HUgn286527
ECgene: TMSB15B H-InvDB: TMSB15B

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for TMSB15B Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for TMSB15B gene:
Search GeneIP for patents involving TMSB15B

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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