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Aliases for TMSB15B Gene

Aliases for TMSB15B Gene

  • Thymosin Beta 15B 2 3
  • Thymosin Beta-15B 3
  • Tbeta15b 3

External Ids for TMSB15B Gene

Summaries for TMSB15B Gene

GeneCards Summary for TMSB15B Gene

TMSB15B is a Protein Coding gene. GO annotations related to this gene include actin binding. An important paralog of this gene is TMSB4Y.

UniProtKB/Swiss-Prot for TMSB15B Gene

  • Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity). May be involved in cell migration.

Gene Wiki entry for TMSB15B Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMSB15B Gene

Genomics for TMSB15B Gene

Genomic Location for TMSB15B Gene

Start:
103,918,896 bp from pter
End:
103,966,712 bp from pter
Size:
47,817 bases
Orientation:
Plus strand

Genomic View for TMSB15B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMSB15B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMSB15B Gene

Regulatory Elements for TMSB15B Gene

Transcription factor binding sites by QIAGEN in the TMSB15B gene promoter:

Proteins for TMSB15B Gene

  • Protein details for TMSB15B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0CG35-TB15B_HUMAN
    Recommended name:
    Thymosin beta-15B
    Protein Accession:
    P0CG35
    Secondary Accessions:
    • A8K614
    • Q99406

    Protein attributes for TMSB15B Gene

    Size:
    45 amino acids
    Molecular mass:
    5229 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMSB15B Gene

Proteomics data for TMSB15B Gene at MOPED

Post-translational modifications for TMSB15B Gene

No Post-translational modifications

Other Protein References for TMSB15B Gene

No data available for DME Specific Peptides for TMSB15B Gene

Domains for TMSB15B Gene

Protein Domains for TMSB15B Gene

UniProtKB/Swiss-Prot:

TB15B_HUMAN
Family:
  • Belongs to the thymosin beta family.:
    • P0CG35
genes like me logo Genes that share domains with TMSB15B: view

No data available for Gene Families for TMSB15B Gene

Function for TMSB15B Gene

Molecular function for TMSB15B Gene

UniProtKB/Swiss-Prot Function: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity). May be involved in cell migration.

Gene Ontology (GO) - Molecular Function for TMSB15B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding --
GO:0003785 actin monomer binding IEA --
genes like me logo Genes that share ontologies with TMSB15B: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TMSB15B Gene

Localization for TMSB15B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMSB15B Gene

Cytoplasm, cytoskeleton.

Gene Ontology (GO) - Cellular Components for TMSB15B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with TMSB15B: view

Pathways for TMSB15B Gene

SuperPathways for TMSB15B Gene

No Data Available

Interacting Proteins for TMSB15B Gene

Gene Ontology (GO) - Biological Process for TMSB15B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007010 cytoskeleton organization --
GO:0007015 actin filament organization IEA --
GO:0030036 actin cytoskeleton organization --
GO:0042989 sequestering of actin monomers IEA --
genes like me logo Genes that share ontologies with TMSB15B: view

No data available for Pathways by source for TMSB15B Gene

Transcripts for TMSB15B Gene

Unigene Clusters for TMSB15B Gene

Thymosin beta 15B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMSB15B Gene

No ASD Table

Relevant External Links for TMSB15B Gene

GeneLoc Exon Structure for
TMSB15B
ECgene alternative splicing isoforms for
TMSB15B

Expression for TMSB15B Gene

mRNA expression in normal human tissues for TMSB15B Gene

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for TMSB15B Gene

SOURCE GeneReport for Unigene cluster for TMSB15B Gene Hs.675540

mRNA Expression by UniProt/SwissProt for TMSB15B Gene

P0CG35-TB15B_HUMAN
Tissue specificity: Expressed in colon and colon cancer tissue.
genes like me logo Genes that share expressions with TMSB15B: view

Orthologs for TMSB15B Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMSB15B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 37
  • 70 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia TMSB4 37
  • 70 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 37
  • 42 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Tmsb15b1 37
  • 80 (a)
ManyToMany
Tmsb15b2 37
  • 46 (a)
ManyToMany
Tmsb15l 37
  • 46 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 68 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 84 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii si:ch211-11c15.3 37
  • 62 (a)
ManyToMany
tmsb 37
  • 53 (a)
ManyToMany
tmsb4x 37
  • 66 (a)
ManyToMany
Species with no ortholog for TMSB15B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMSB15B Gene

ENSEMBL:
Gene Tree for TMSB15B (if available)
TreeFam:
Gene Tree for TMSB15B (if available)

Paralogs for TMSB15B Gene

Paralogs for TMSB15B Gene

genes like me logo Genes that share paralogs with TMSB15B: view

Variants for TMSB15B Gene

Sequence variations from dbSNP and Humsavar for TMSB15B Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs1180753 -- 103,964,431(+) GGGAT(C/T)GCGCC intron-variant
rs3752328 -- 103,962,767(+) GGGAC(G/T)GGAAG intron-variant
rs12858641 -- 103,963,879(+) TCTGG(G/T)CTTGT intron-variant
rs45493994 -- 103,962,565(+) GAAGG(A/C)GGCGA upstream-variant-2KB
rs56041712 -- 103,961,698(+) TACAT(C/T)CTAGA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TMSB15B Gene

Variant ID Type Subtype PubMed ID
dgv2459e1 CNV Complex 17122850
nsv469772 CNV Complex 16826518
nsv519626 CNV Gain 19592680
nsv7453 OTHER Inversion 18451855
esv27035 CNV Gain 19812545
esv1007027 OTHER Inversion 20482838

Relevant External Links for TMSB15B Gene

HapMap Linkage Disequilibrium report
TMSB15B

Disorders for TMSB15B Gene

No disorders were found for TMSB15B Gene.

No data available for UniProtKB/Swiss-Prot for TMSB15B Gene

Publications for TMSB15B Gene

  1. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PMID: 12665801) Gevaert K. … Vandekerckhove J. (Nat. Biotechnol. 2003) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4
  4. Thymosin beta-NB is the human isoform of rat thymosin beta15. (PMID: 17567946) Banyard J. … Zetter B.R. (Ann. N. Y. Acad. Sci. 2007) 2 3
  5. Differential regulation of human thymosin beta 15 isoforms by transforming growth factor beta 1. (PMID: 19296525) Banyard J. … Zetter B.R. (Genes Chromosomes Cancer 2009) 3 4

Products for TMSB15B Gene

Sources for TMSB15B Gene

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