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Aliases for TMSB15A Gene

Aliases for TMSB15A Gene

  • Thymosin-Like Protein 8 3 4
  • Thymosin Beta 15a 2 3
  • NB Thymosin Beta 3 4
  • Thymosin-Like 8 2 3
  • TMSL8 3 4
  • TMSNB 3 4
  • Thymosin, Beta, Identified In Neuroblastoma Cells 3
  • Thymosin Beta-15B 3
  • Thymosin Beta-15A 3
  • TMSB15B 3
  • TMSB15 3
  • Tb15 3
  • TbNB 3

External Ids for TMSB15A Gene

Previous HGNC Symbols for TMSB15A Gene

  • TMSL8

Previous GeneCards Identifiers for TMSB15A Gene

  • GC0XM101657
  • GC0XM101768
  • GC0XM091433

Summaries for TMSB15A Gene

GeneCards Summary for TMSB15A Gene

TMSB15A is a Protein Coding gene. Diseases associated with TMSB15A include neuroblastoma. GO annotations related to this gene include actin binding. An important paralog of this gene is TMSB15B.

UniProtKB/Swiss-Prot for TMSB15A Gene

  • Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity).

Gene Wiki entry for TMSB15A Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMSB15A Gene

Genomics for TMSB15A Gene

Regulatory Elements for TMSB15A Gene

Genomic Location for TMSB15A Gene

Start:
102,513,676 bp from pter
End:
102,516,784 bp from pter
Size:
3,109 bases
Orientation:
Minus strand

Genomic View for TMSB15A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMSB15A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMSB15A Gene

Proteins for TMSB15A Gene

  • Protein details for TMSB15A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0CG34-TB15A_HUMAN
    Recommended name:
    Thymosin beta-15A
    Protein Accession:
    P0CG34
    Secondary Accessions:
    • A8K614
    • Q99406

    Protein attributes for TMSB15A Gene

    Size:
    45 amino acids
    Molecular mass:
    5229 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMSB15A Gene

Proteomics data for TMSB15A Gene at MOPED

Post-translational modifications for TMSB15A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMSB15A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMSB15A Gene

Domains for TMSB15A Gene

Protein Domains for TMSB15A Gene

Suggested Antigen Peptide Sequences for TMSB15A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P0CG34

UniProtKB/Swiss-Prot:

TB15A_HUMAN :
  • P0CG34
Family:
  • Belongs to the thymosin beta family.
genes like me logo Genes that share domains with TMSB15A: view

No data available for Gene Families for TMSB15A Gene

Function for TMSB15A Gene

Molecular function for TMSB15A Gene

UniProtKB/Swiss-Prot Function: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity).
UniProtKB/Swiss-Prot Induction: Down-regulated by TGFB1.

Gene Ontology (GO) - Molecular Function for TMSB15A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding --
GO:0003785 actin monomer binding IEA --
genes like me logo Genes that share ontologies with TMSB15A: view

Phenotypes for TMSB15A Gene

GenomeRNAi human phenotypes for TMSB15A:
genes like me logo Genes that share phenotypes with TMSB15A: view

Animal Model Products

CRISPR Products

miRNA for TMSB15A Gene

miRTarBase miRNAs that target TMSB15A

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMSB15A

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TMSB15A Gene

Localization for TMSB15A Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMSB15A Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMSB15A Gene COMPARTMENTS Subcellular localization image for TMSB15A gene
Compartment Confidence
cytosol 3
cytoskeleton 2
extracellular 2
nucleus 1

Gene Ontology (GO) - Cellular Components for TMSB15A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with TMSB15A: view

Pathways for TMSB15A Gene

SuperPathways for TMSB15A Gene

No Data Available

Interacting Proteins for TMSB15A Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000289373%0d%0a9606.ENSP00000225655%0d%0a9606.ENSP00000322170%0d%0a9606.ENSP00000239940%0d%0a
Selected Interacting proteins: ENSP00000289373 for TMSB15A Gene via STRING

Gene Ontology (GO) - Biological Process for TMSB15A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007010 cytoskeleton organization --
GO:0007015 actin filament organization IEA --
GO:0030036 actin cytoskeleton organization --
GO:0042989 sequestering of actin monomers IEA --
genes like me logo Genes that share ontologies with TMSB15A: view

No data available for Pathways by source for TMSB15A Gene

Transcripts for TMSB15A Gene

mRNA/cDNA for TMSB15A Gene

(72) Selected AceView cDNA sequences:
(4) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMSB15A Gene

Thymosin beta 15a:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMSB15A

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMSB15A Gene

No ASD Table

Relevant External Links for TMSB15A Gene

GeneLoc Exon Structure for
TMSB15A
ECgene alternative splicing isoforms for
TMSB15A

Expression for TMSB15A Gene

mRNA expression in normal human tissues for TMSB15A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMSB15A Gene

This gene is overexpressed in Prostate (5.2).

SOURCE GeneReport for Unigene cluster for TMSB15A Gene Hs.56145

mRNA Expression by UniProt/SwissProt for TMSB15A Gene

P0CG34-TB15A_HUMAN
Tissue specificity: Neuroblastoma-specific.
genes like me logo Genes that share expressions with TMSB15A: view

In Situ Assay Products

No data available for Protein expression for TMSB15A Gene

Orthologs for TMSB15A Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMSB15A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMSB15A 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 58 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 70 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Tmsb15b1 36
  • 80 (a)
ManyToMany
Tmsb15b2 36
  • 46 (a)
ManyToMany
Tmsb15l 36
  • 46 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 84 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii si:ch211-11c15.3 36
  • 62 (a)
ManyToMany
tmsb 36
  • 53 (a)
ManyToMany
tmsb4x 36
  • 66 (a)
ManyToMany
Species with no ortholog for TMSB15A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMSB15A Gene

ENSEMBL:
Gene Tree for TMSB15A (if available)
TreeFam:
Gene Tree for TMSB15A (if available)

Paralogs for TMSB15A Gene

Paralogs for TMSB15A Gene

Selected SIMAP similar genes for TMSB15A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TMSB15A: view

Variants for TMSB15A Gene

Sequence variations from dbSNP and Humsavar for TMSB15A Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs1802647 -- 102,514,050(-) ACATT(A/C)CCTGA utr-variant-3-prime
rs2235840 -- 102,515,511(+) ACAGG(A/G)ACAGA intron-variant
rs5987612 -- 102,518,362(+) CATCC(C/G)CTCTT upstream-variant-2KB
rs7065697 -- 102,518,310(+) cccca(A/G)gacac upstream-variant-2KB
rs11557378 -- 102,513,798(+) TAGCA(G/T)GTTAA utr-variant-3-prime

Relevant External Links for TMSB15A Gene

HapMap Linkage Disequilibrium report
TMSB15A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TMSB15A Gene

Disorders for TMSB15A Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for TMSB15A Gene including...

Search for TMSB15A Gene in MalaCards »
genes like me logo Genes that share disorders with TMSB15A: view

No data available for UniProtKB/Swiss-Prot for TMSB15A Gene

Publications for TMSB15A Gene

  1. Thymosin beta-NB is the human isoform of rat thymosin beta15. (PMID: 17567946) Banyard J. … Zetter B.R. (Ann. N. Y. Acad. Sci. 2007) 2 3 23
  2. Differential regulation of human thymosin beta 15 isoforms by transforming growth factor beta 1. (PMID: 19296525) Banyard J. … Zetter B.R. (Genes Chromosomes Cancer 2009) 3 4 23
  3. Identification and cloning of neuroblastoma-specific and nerve tissue-specific genes through compiled expression profiles. (PMID: 9039501) Yokoyama M. … Matsubara K. (DNA Res. 1996) 2 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4

Products for TMSB15A Gene

Sources for TMSB15A Gene

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