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Aliases for TMSB15A Gene

Aliases for TMSB15A Gene

  • Thymosin Beta 15a 2 3 5
  • Thymosin-Like Protein 8 3 4
  • NB Thymosin Beta 3 4
  • Thymosin-Like 8 2 3
  • TMSL8 3 4
  • TMSNB 3 4
  • Thymosin, Beta, Identified In Neuroblastoma Cells 3
  • Thymosin Beta-15B 3
  • TMSB15B 3
  • TMSB15 3
  • Tb15 3
  • TbNB 3

External Ids for TMSB15A Gene

Previous HGNC Symbols for TMSB15A Gene

  • TMSL8

Previous GeneCards Identifiers for TMSB15A Gene

  • GC0XM101657
  • GC0XM101768
  • GC0XM091433

Summaries for TMSB15A Gene

GeneCards Summary for TMSB15A Gene

TMSB15A (Thymosin Beta 15a) is a Protein Coding gene. Diseases associated with TMSB15A include Neuroblastoma. GO annotations related to this gene include actin binding and actin monomer binding. An important paralog of this gene is TMSB15B.

UniProtKB/Swiss-Prot for TMSB15A Gene

  • Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity).

Gene Wiki entry for TMSB15A Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMSB15A Gene

Genomics for TMSB15A Gene

Regulatory Elements for TMSB15A Gene

Enhancers for TMSB15A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TMSB15A on UCSC Golden Path with GeneCards custom track

Promoters for TMSB15A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TMSB15A on UCSC Golden Path with GeneCards custom track

Genomic Location for TMSB15A Gene

102,513,676 bp from pter
102,516,784 bp from pter
3,109 bases
Minus strand

Genomic View for TMSB15A Gene

Genes around TMSB15A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMSB15A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMSB15A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMSB15A Gene

Proteins for TMSB15A Gene

  • Protein details for TMSB15A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Thymosin beta-15A
    Protein Accession:
    Secondary Accessions:
    • A8K614
    • Q99406

    Protein attributes for TMSB15A Gene

    45 amino acids
    Molecular mass:
    5229 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMSB15A Gene

Proteomics data for TMSB15A Gene at MOPED

Post-translational modifications for TMSB15A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMSB15A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMSB15A Gene

Domains & Families for TMSB15A Gene

Protein Domains for TMSB15A Gene


Suggested Antigen Peptide Sequences for TMSB15A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the thymosin beta family.
  • Belongs to the thymosin beta family.
genes like me logo Genes that share domains with TMSB15A: view

No data available for Gene Families for TMSB15A Gene

Function for TMSB15A Gene

Molecular function for TMSB15A Gene

UniProtKB/Swiss-Prot Function:
Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity).
UniProtKB/Swiss-Prot Induction:
Down-regulated by TGFB1.
genes like me logo Genes that share phenotypes with TMSB15A: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TMSB15A

CRISPR Products

miRNA for TMSB15A Gene

miRTarBase miRNAs that target TMSB15A

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMSB15A Gene

Localization for TMSB15A Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMSB15A Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

Jensen Localization Image for TMSB15A Gene COMPARTMENTS Subcellular localization image for TMSB15A gene
Compartment Confidence
cytoskeleton 3
cytosol 3
extracellular 2
nucleus 1

Gene Ontology (GO) - Cellular Components for TMSB15A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with TMSB15A: view

Pathways & Interactions for TMSB15A Gene

SuperPathways for TMSB15A Gene

No Data Available

Interacting Proteins for TMSB15A Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
Selected Interacting proteins: ENSP00000289373 for TMSB15A Gene via STRING

Gene Ontology (GO) - Biological Process for TMSB15A Gene


No data available for Pathways by source and SIGNOR curated interactions for TMSB15A Gene

Drugs & Compounds for TMSB15A Gene

No Compound Related Data Available

Transcripts for TMSB15A Gene

mRNA/cDNA for TMSB15A Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(72) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMSB15A Gene

Thymosin beta 15a:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMSB15A Gene

No ASD Table

Relevant External Links for TMSB15A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMSB15A Gene

mRNA expression in normal human tissues for TMSB15A Gene

mRNA differential expression in normal tissues according to GTEx for TMSB15A Gene

This gene is overexpressed in Prostate (x5.2).

SOURCE GeneReport for Unigene cluster for TMSB15A Gene Hs.56145

mRNA Expression by UniProt/SwissProt for TMSB15A Gene

Tissue specificity: Neuroblastoma-specific.
genes like me logo Genes that share expression patterns with TMSB15A: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for TMSB15A Gene

Orthologs for TMSB15A Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMSB15A Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia -- 36
  • 58 (a)
(Canis familiaris)
Mammalia -- 36
  • 70 (a)
(Mus musculus)
Mammalia Tmsb15b1 36
  • 80 (a)
Tmsb15b2 36
  • 46 (a)
Tmsb15l 36
  • 46 (a)
(Pan troglodytes)
Mammalia TMSB15A 36
  • 100 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 84 (a)
(Danio rerio)
Actinopterygii si:ch211-11c15.3 36
  • 62 (a)
tmsb 36
  • 53 (a)
tmsb4x 36
  • 66 (a)
Species with no ortholog for TMSB15A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMSB15A Gene

Gene Tree for TMSB15A (if available)
Gene Tree for TMSB15A (if available)

Paralogs for TMSB15A Gene

Paralogs for TMSB15A Gene

(5) SIMAP similar genes for TMSB15A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TMSB15A: view

Variants for TMSB15A Gene

Sequence variations from dbSNP and Humsavar for TMSB15A Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1802647 -- 102,514,050(-) ACATT(A/C)CCTGA utr-variant-3-prime
rs2235840 -- 102,515,511(+) ACAGG(A/G)ACAGA intron-variant
rs5987612 -- 102,518,362(+) CATCC(C/G)CTCTT upstream-variant-2KB
rs7065697 -- 102,518,310(+) cccca(A/G)gacac upstream-variant-2KB
rs11557378 -- 102,513,798(+) TAGCA(G/T)GTTAA utr-variant-3-prime

Variation tolerance for TMSB15A Gene

Residual Variation Intolerance Score: 48.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.01; 0.18% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for TMSB15A Gene

Disorders for TMSB15A Gene

MalaCards: The human disease database

(1) MalaCards diseases for TMSB15A Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
  • neuroblastoma 1
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TMSB15A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TMSB15A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TMSB15A Gene

Publications for TMSB15A Gene

  1. Identification and cloning of neuroblastoma-specific and nerve tissue-specific genes through compiled expression profiles. (PMID: 9039501) Yokoyama M. … Matsubara K. (DNA Res. 1996) 2 3 4 67
  2. Thymosin beta-NB is the human isoform of rat thymosin beta15. (PMID: 17567946) Banyard J. … Zetter B.R. (Ann. N. Y. Acad. Sci. 2007) 2 3 23
  3. Differential regulation of human thymosin beta 15 isoforms by transforming growth factor beta 1. (PMID: 19296525) Banyard J. … Zetter B.R. (Genes Chromosomes Cancer 2009) 3 23
  4. Thymosin beta 15A (TMSB15A) is a predictor of chemotherapy response in triple-negative breast cancer. (PMID: 23079573) Darb-Esfahani S. … Loibl S. (Br. J. Cancer 2012) 3
  5. Expression and subcellular localization of thymosin beta15 following kainic acid treatment in rat brain. (PMID: 18452710) Kim Y.W. … Kim H. (Biochem. Biophys. Res. Commun. 2008) 3

Products for TMSB15A Gene

Sources for TMSB15A Gene