Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneAnalytics
- GeneLoc
- GenesLikeMe
- VarElect
- PathCards
Terms of Use
- Terms of Use
- 3rd Party Notice
About Us
- GeneCards Team
- Our Publications
- Citing GeneCards
- Licensing Agreement
- Weizmann Institute
- LifeMap Sciences Inc
User Feedback
GeneCards Plus
- Premium Tools
  
  Learn more

Set Analyses:

VarElect

Advanced Search

TMSB10 Gene

protein-coding GIFtS: 54
GCID: GC02P085132

Thymosin Beta 10

See TMSB10-related disease
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

TryGeneCards Plus

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Thymosin Beta 10¹ ²		Migration-Inducing Protein 12²
MIG12²		Thymosin Beta-10²
TB10²		PTMB10³
Migration-Inducing Gene 12²		THYB10³

External Ids:	HGNC: 11879¹	Entrez Gene: 9168²	Ensembl: ENSG00000034510⁷	OMIM: 188399⁵	UniProtKB: P63313³

ORGUL members:

Export aliases for TMSB10 gene to outside databases

Previous GC identifers: GC02P085114 GC02P085426 GC02P085090 GC02P085107 GC02P085044 GC02P084986

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for TMSB10 Gene:

TMSB10 (thymosin beta 10) is a protein-coding gene. Diseases associated with TMSB10 include chronic graft versus host disease. GO annotations related to this gene include actin binding. An important paralog of this gene is TMSB15B.

UniProtKB/Swiss-Prot: TYB10_HUMAN, P63313

Function: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers

(G actin) and therefore inhibits actin polymerization (By similarity)

Gene Wiki entry for TMSB10 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus

RefSeq DNA sequence at NCBI GenBank:

NC_000002.11 NC_018913.2 NT_022184.16

Regulatory elements:

Regulatory transcription factor binding sites in the TMSB10 gene promoter:
p53 AP-1 p300 FOXO4 ATF-2 c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TMSB10 promoter sequence

Search Chromatin IP Primers for TMSB10

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TMSB10

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p11.2 Ensembl cytogenetic band: 2p11.2 HGNC cytogenetic band: 2p11.2

TMSB10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMSB10 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02P085132: view genomic region (about GC identifiers)

Start:	85,132,749 bp from pter	End:	85,133,799 bp from pter
Size:	1,051 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: TYB10_HUMAN, P63313 (See protein sequence)

Recommended Name: Thymosin beta-10

Size: 44 amino acids; 5026 Da

Developmental stage: Found to decrease dramatically after birth

Sequence caution: Sequence=AAA36746.1; Type=Erroneous initiation; Sequence=AAC41691.1; Type=Erroneous initiation;

Secondary accessions: P13472 Q596K9

Explore the universe of human proteins at neXtProt for TMSB10: NX_P63313

Explore proteomics data for TMSB10 at MOPED

Post-translational modifications:

Ubiquitination² at Lys4, Lys15, Lys26, Lys32

Modification sites at PhosphoSitePlus

See TMSB10 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_066926.1

ENSEMBL proteins:

ENSP00000233143

TMSB10 Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein for TMSB10 OriGene Protein Over-expression Lysate for TMSB10 OriGene MassSpec for TMSB10 OriGene Custom Protein Services for TMSB10
	GenScript Custom Purified and Recombinant Proteins Services for TMSB10
	Novus Biologicals TMSB10 Protein Novus Biologicals TMSB10 Lysate
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Cloud-Clone Corp.
	Search eBioscience for Proteins for TMSB10
	antibodies-online proteins for TMSB10 (10 products)
	Search antibodies-online for peptides for TMSB10

TMSB10 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for TMSB10 (Thymosin beta 10)
	OriGene Antibodies for TMSB10 OriGene Custom Antibody Services for TMSB10
	Novus Biologicals TMSB10 Antibodies
	Abcam antibodies for TMSB10
	Browse Antibodies at Cloud-Clone Corp.
	Search ThermoFisher Antibodies for TMSB10
	antibodies-online antibodies for TMSB10 (30 products)

TMSB10 Assay Products:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for TMSB10
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for TMSB10
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs at Cloud-Clone Corp. Browse CLIAs at Cloud-Clone Corp.
	Search eBioscience for ELISAs for TMSB10
	antibodies-online kits for TMSB10 (30 products)

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TryGeneCards Plus

2 InterPro protein domains:

IPR001152 Thymosin_b4

IPR016323 Thymosin_b4_metazoa

Graphical View of Domain Structure for InterPro Entry P63313

ProtoNet protein and cluster: P63313

1 Blocks protein domain: IPB001152 Thymosin beta-4

UniProtKB/Swiss-Prot: TYB10_HUMAN, P63313

Similarity: Belongs to the thymosin beta family

Find genes that share domains with TMSB10 About GenesLikeMe

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Molecular Function:

UniProtKB/Swiss-Prot Summary: TYB10_HUMAN, P63313

Function: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers

(G actin) and therefore inhibits actin polymerization (By similarity)

Gene Ontology (GO): 1 molecular function term: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003779	actin binding	IEA	--

Find genes that share ontologies with TMSB10 About GenesLikeMe

Animal Models:

genOway: Develop your customized and physiologically relevant rodent model for TMSB10

miRNA Products:		miRTarBase miRNAs that target TMSB10: hsa-mir-17-5p (MIRT051009), hsa-mir-101-5p (MIRT038714), hsa-mir-615-3p (MIRT040459)

		Block miRNA regulation of human, mouse, rat TMSB10 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate TMSB10 (see all 9):
		hsa-miR-148b hsa-miR-27a hsa-miR-657 hsa-miR-128 hsa-miR-3681* hsa-miR-1301 hsa-miR-152 hsa-miR-27b

		SwitchGear 3'UTR luciferase reporter plasmid: TMSB10 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for TMSB10
		Predesigned siRNA for gene silencing in human, mouse, rat TMSB10

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for TMSB10

Clone Products:		OriGene clones in human, mouse for TMSB10 (see all 8) OriGene ORF clones in mouse, rat for TMSB10 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: TMSB10 (NM_021103)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMSB10
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMSB10

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for TMSB10
		Browse ESI BIO Cell Lines and PureStem Progenitors for TMSB10

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMSB10

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Subcellular locations from UniProtKB/Swiss-Prot

TYB10_HUMAN, P63313: Cytoplasm, cytoskeleton

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
cytoskeleton	5
cytosol	3

About this image

Gene Ontology (GO): 2 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--
GO:0005856	cytoskeleton	IEA	--

Find genes that share ontologies with TMSB10 About GenesLikeMe

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
About This Section

TryGeneCards Plus

Pathway & Disease-focused RT² Profiler PCR Array including TMSB10:

Nephrotoxicity in human mouse rat

Interactions:

Search GeneGlobe Interaction Network for TMSB10

STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

Selected Interacting proteins for TMSB10 (P63313³ ENSP00000233143⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 15)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TMOD1	P28289³, ENSP00000259365⁴	I2D: score=1 STRING: ENSP00000259365
FOS	P01100³, ENSP00000306245⁴	I2D: score=1 STRING: ENSP00000306245
SUFU	ENSP00000358918⁴	STRING: ENSP00000358918
UBC	ENSP00000344818⁴	STRING: ENSP00000344818
POT1	ENSP00000350249⁴	STRING: ENSP00000350249

About this table

Gene Ontology (GO): 3 biological process terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007010	cytoskeleton organization	--	--
GO:0030036	actin cytoskeleton organization	IEA	--
GO:0042989	sequestering of actin monomers	IEA	--

Find genes that share ontologies with TMSB10 About GenesLikeMe

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
About This Section

TryGeneCards Plus

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for TMSB10 (TYB10)

2 Novoseek inferred chemical compound relationships for TMSB10 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
retinoic acid	28.8	2	2169566 (2)
vegf	23.9	9	11156961 (3), 16496302 (2), 12914774 (1), 18854659 (1)

Find genes that share compounds with TMSB10 About GenesLikeMe

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
About This Section

TryGeneCards Plus

REFSEQ mRNAs for TMSB10 gene:

NM_021103.3

Unigene Cluster for TMSB10:

Thymosin beta 10

Hs.446574 [show with all ESTs]

Unigene Representative Sequence: BQ276852

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000233143(uc002sow.1)

miRNA Products:		Block miRNA regulation of human, mouse, rat TMSB10 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate TMSB10 (see all 9):
		hsa-miR-148b hsa-miR-27a hsa-miR-657 hsa-miR-128 hsa-miR-3681* hsa-miR-1301 hsa-miR-152 hsa-miR-27b

		SwitchGear 3'UTR luciferase reporter plasmid: TMSB10 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for TMSB10
		Predesigned siRNA for gene silencing in human, mouse, rat TMSB10

Clone Products:		OriGene clones in human, mouse for TMSB10 (see all 8) OriGene ORF clones in mouse, rat for TMSB10 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: TMSB10 (NM_021103)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMSB10
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMSB10

Primer Products:		OriGene qPCR primer pairs and template standards for TMSB10
		Pre-validated RT² qPCR Primer Assay in human, mouse / rat TMSB10
		QuantiTect SYBR Green Assays in human, mouse, rat TMSB10
		QuantiFast Probe-based Assays in human, mouse, rat TMSB10

Additional mRNA sequence:

AK130949.1 AK311952.1 AY453400.1 BC016025.1 BC016731.1 BC107889.1 M20259.1 M92381.1

S54005.1

Selected DOTS entries (see all 41):

DT.455409 DT.99926681 DT.99926733 DT.121001526 DT.100701944 DT.95219544 DT.101985573 DT.121001374

DT.95222543 DT.100701960 DT.99994789 DT.100848983 DT.100757256 DT.97760238 DT.101985574 DT.121001398

DT.92466041 DT.92466043 DT.100701909 DT.100701911 DT.121001388 DT.121001422 DT.95221885 DT.100701924

Selected AceView cDNA sequences (see all 1350):

BQ083925 AA640068 BQ222149 BM460102 AU103130 AI499000 CB110632 T27818

CB156637 BU789133 BE909902 BF726605 CB119763 F24712 AW163694 BP428861

BM842129 CB127872 AJ709478 AI081185 AU103129 CB111668 BM800103 BQ672252

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for TMSB10 About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3a	·	3b	·	3c	·	3d
SP1:									-
SP2:
SP3:									-

ECgene alternative splicing isoforms for TMSB10

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TryGeneCards Plus

TMSB10 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GGGGAAATCG

About this image

TMSB10 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 8) fully expand


Neural Tube (Nervous System) fully expand to see all 3 entries
Spinal Ventral Columns

Limb (Muscoskeletal System) fully expand to see all 2 entries
Prechondrocytic Mesenchymal Cells Zeugopod
Limb Bud

Ovary (Reproductive System)
Primary Oocyte Primary Follicle

Gonad
Primary Oocyte Primary Follicle

Bone (Muscoskeletal System)
Prechondrocytic Mesenchymal Cells Zeugopod

TMSB10 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

TMSB10 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.446574

Pathway & Disease-focused RT² Profiler PCR Array including TMSB10:

Nephrotoxicity in human mouse rat

Primer Products:		OriGene qPCR primer pairs and template standards for TMSB10
		Pre-validated RT² qPCR Primer Assay in human, mouse / rat TMSB10
		QuantiTect SYBR Green Assays in human, mouse, rat TMSB10
		QuantiFast Probe-based Assays in human, mouse, rat TMSB10

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMSB10

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

TryGeneCards Plus

This gene was present in the common ancestor of chordates.

Orthologs for TMSB10 gene from Selected species (see all 8) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Tmsb10⁵	thymosin, beta 10	--		6 (32.35 cM) 72957347
chicken (Gallus gallus)	Aves	TMSB10⁶	thymosin beta 10	73(a)	1 ↔ 1	13(13676142-13677119) ENSGALG00000018624
zebrafish (Danio rerio)	Actinopterygii	tmsb⁶ tmsb4x⁶ (see all 3)	thymosin, beta 4 x (see all 3)	73(a) 70(a) (see all 3)	many ↔ many many ↔ many (see all 3)	21(25782878-25786220) ENSDARG00000054911 9(56198178-56199762) ENSDARG00000077777

ENSEMBL Gene Tree for TMSB10 (if available)
TreeFam Gene Tree for TMSB10 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

TryGeneCards Plus

Paralogs for TMSB10 gene

TMSB15B² TMSB15A² TMSB4Y² TMSB4X²

5 SIMAP similar genes for TMSB10 using alignment to 2 protein entries: TYB10_HUMAN (see all proteins):

TMSB15A TMSB15B TMSB4X TMSB4XP4 TMSB4Y

Find genes that share paralogs with TMSB10 About GenesLikeMe

3 Pseudogenes.org Pseudogenes for TMSB10
PGOHUM00000240566 PGOHUM00000235972 PGOHUM00000241657

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

TryGeneCards Plus

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs146395141^1,2	C	--	85130764(+)	`ATAAGC/TGTGAT`	1	--	us2k¹		0	--	--	--	--
rs190065998^1,2	C	--	85130917(+)	`ACCCCA/GTCTCT`	1	--	us2k¹		0	--	--	--	--
rs10180066^1,2	C	--	85130921(+)	`cgtctC/Ttacta`	1	--	us2k¹		0	--	--	--	--
rs6711942^1,2	C,F	--	85130945(+)	`tagccG/Agacat`	1	--	us2k¹		1		NA	4
rs6712044^1,2	C	--	85131013(+)	`aacccA/Gggagg`	1	--	us2k¹		0	--	--	--	--
rs12477539^1,2	H	--	85131095(+)	`aaagaA/Gaaaaa`	1	--	us2k¹ trp³		0	--	--	--	--
rs6715126^1,2	C,F,A,H	--	85131170(+)	`aaaaaG/Aaaaga`	1	--	us2k¹ trp³		9		NS EA NA WA CSA	719
rs144342983^1,2	C	--	85131170(+)	`AAAAA-/GAAAGA`	1	--	us2k¹		0	--	--	--	--
rs144357200^1,2		--	85131197(+)	`TGCCTC/TTTCTT`	1	--	us2k¹		0	--	--	--	--
rs148738174^1,2		--	85131280(+)	`ACAAGC/GCTATG`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for TMSB10 (85132749 - 85133799 bp)

Structural Variations
Database of Genomic Variants (DGV) 1 variation for TMSB10: About this table

Variant ID	Type	Subtype	PubMed ID
dgv4201n71	CNV	Loss	21882294

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing TMSB10

DNA2.0 Custom Variant and Variant Library Synthesis for TMSB10

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TryGeneCards Plus

OMIM gene information: 188399 OMIM disorders: --

1 disease for TMSB10:
About MalaCards

chronic graft versus host disease

1 inferred disease relationship from the University of Copenhagen DISEASES database for TMSB10:

Tuberculosis

Find genes that share disorders with TMSB10 About GenesLikeMe

Selected Novoseek inferred disease relationships for TMSB10 gene (see all 11) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
thyroid carcinoma	48.1	2	15254683 (1), 10487837 (1)
neoplastic transformation	33.7	1	9485041 (1)
pancreatic carcinoma	31	6	15983444 (1)
goiter	26.9	3	10366416 (2)
melanoma	15.7	4	8425765 (3)
tumors	15	13	14989934 (2), 14975205 (2), 11956663 (1), 15983444 (1) (see all 7)
cancer lung	15	4	18789485 (3)
cancer	14.9	8	11709704 (1), 19909017 (1), 11710837 (1), 16786322 (1) (see all 7)
breast cancer	13.3	3	16786322 (2), 8912542 (1)
ovarian cancer	4.89	6	11709704 (2)

Export disorders for TMSB10 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

TryGeneCards Plus

PubMed articles for TMSB10 gene, integrated from 10 sources (see all 81):
(articles sorted by number of sources associating them with TMSB10)

Utopia: connect your pdf to the dynamic
world of online information

Sequence of a human kidney cDNA clone encoding thymosin beta 10. (PubMed id 3365256)^{1, 2, 3} McCreary V.... Toback F.G. (Biochem. Biophys. Res. Commun. 1988)
Thymosin beta 10 levels in developing human brain and its regulation by retinoic acid in the HTB-10 neuroblastoma. (PubMed id 2169566)^{1, 2, 9} Hall A.K.... Morgan J.I. (Brain Res. Mol. Brain Res. 1990)
Thymosin beta-10 expression in melanoma cell lines and melanocytic lesions: a new progression marker for human cutaneous melanoma. (PubMed id 8425765)^{1, 2, 9} Weterman M.A.... Bloemers H.P.J. (Int. J. Cancer 1993)
Thymosin beta-10 gene overexpression is a general event in human carcinogenesis. (PubMed id 10487837)^{1, 3, 9} Santelli G....Fusco A. (Am. J. Pathol. 1999)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
Localization of thymosin beta10 in breast cancer cells: relationship to actin cytoskeletal remodeling and cell motility. (PubMed id 16786322)^{1, 9} Maelan A.E....Larsson L.I. (Histochem. Cell Biol. 2007)
Expression of thymosin beta10 and its role in non-small cell lung cancer. (PubMed id 18789485)^{1, 9} Gu Y....Wang E. (Hum. Pathol. 2009)
The interaction between E-tropomodulin and thymosin beta-10 rescues tumor cells from thymosin beta-10 mediated apoptosis by restoring actin architecture. (PubMed id 14741341)^{1, 9} Rho S.B....Lee J.H. (FEBS Lett. 2004)
Thymosin beta-10 is aberrantly expressed in pancreatic cancer and induces JNK activation. (PubMed id 19194824)^{1, 9} Li M....Yao Q. (Cancer Invest. 2009)
The identification of apoptosis-related residues in human thymosin beta-10 by mutational analysis and computational modeling. (PubMed id 16012174)^{1, 9} Rho S.B....Lee J.H. (J. Biol. Chem. 2005)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

TryGeneCards Plus

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

TryGeneCards Plus

Entrez Gene: 9168	HGNC: 11879	AceView: TMSB10	Ensembl:ENSG00000034510	euGenes: HUgn9168
ECgene: TMSB10	H-InvDB: TMSB10

(According to HUGE)
About This Section

TryGeneCards Plus

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section

TryGeneCards Plus

Name	Description
PharmGKB entry for TMSB10	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for TMSB10	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for TMSB10 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

TryGeneCards Plus

Patent Information for TMSB10 gene:
Search GeneIP for patents involving TMSB10

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
About This Section

TryGeneCards Plus


	EMD Millipore genomic analysis products

	Antibodies for TMSB10 (Thymosin beta 10)		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Enzyme Activity Assays/Reagents
	Browse ELISpot/FluoroSpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Luminex Assays
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Recombinant/Natural Proteins		Browse Stem Cell Products
	Browse cDNA Clones		Browse Proteome Profiler Antibody Arrays

	OriGene Antibodies for TMSB10		OriGene RNAi products in human, mouse, rat for TMSB10
	OriGene qPCR primer pairs and template standards for TMSB10		OriGene Protein Over-expression Lysate for TMSB10
	OriGene MassSpec for TMSB10		OriGene clones in human, mouse for TMSB10
	Browse OriGene qSTAR qPCR primer pairs		OriGene Purified Protein for TMSB10
	OriGene ORF clones in mouse, rat for TMSB10		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for TMSB10		OriGene Custom Protein Services for TMSB10

	Block miRNA regulation of human, mouse, rat TMSB10 using miScript Target Protectors		SeqTarget long-range PCR primers for resequencing TMSB10
	DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TMSB10		Predesigned siRNA for gene silencing in human, mouse, rat TMSB10
	QuantiFast Probe-based Assays in human, mouse, rat TMSB10		QuantiTect SYBR Green Assays in human, mouse, rat TMSB10
	PCR Arrays including human, mouse, rat TMSB10		Search Chromatin IP Primers for TMSB10
	Pre-validated RT² qPCR Primer Assay in human, mouse / rat TMSB10		Search GeneGlobe Interaction Network for TMSB10
	Regulatory tfbs in TMSB10 promoter

	GenScript Custom Purified and Recombinant Proteins Services for TMSB10		GenScript cDNA clones with any tag delivered in your preferred vector for TMSB10
	GenScript Custom Assay Services for TMSB10		GenScript Custom overexpressing Cell Line Services for TMSB10
	CloneReady with Over 120,000 Genes		Gene Synthesis: Any Gene in Any Vector
	Vector-based siRNA and miRNA, Ready for Transfection		Gene Mutant Library, Variants up to 10^11
	Plasmid Preparation		Custom Peptide Services

Search for Antibodies & Assays

Search Tocris compounds for TMSB10 (TYB10)

	Browse Sino Biological Proteins
	Browse Sino Biological Cell Lysates
	Browse Sino Biological cDNA Clones
	4000+ Proteins
	Search Sino Biological for antibodies, proteins & pathways
	Protein Production Services
	Transfection Reagents
	Protein A/G/L resins
	Isotyping reagents

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	TMSB10 antibodies
	TMSB10 proteins
	TMSB10 lysates

	Antibodies for TMSB10
	See all of Abcam's Antibodies, Kits and Proteins for TMSB10
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

	Browse Proteins at Cloud-Clone Corp.
	Browse Antibodies at Cloud-Clone Corp.
	Browse ELISAs at Cloud-Clone Corp.
	Browse CLIAs at Cloud-Clone Corp.

Browse ESI BIO Cell Lines and PureStem Progenitors for TMSB10

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMSB10

	SwitchGear 3'UTR luciferase reporter plasmids for TMSB10
	SwitchGear Promoter luciferase reporter plasmids for TMSB10

Search ThermoFisher Antibodies for TMSB10

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMSB10

Browse compounds at ApexBio

Search Addgene for plasmids for TMSB10

	Search eBioscience for proteins for TMSB10
	Search eBioscience for elisas for TMSB10
	eBioscience FlowRNA Probe Sets

genOway: Develop your customized and physiologically relevant rodent model for TMSB10

	antibodies-online antibodies for TMSB10 (30 products)
	antibodies-online kits for TMSB10 (30 products)
	Search antibodies-online for peptides for TMSB10
	antibodies-online proteins for TMSB10 (10 products)

GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 2 Nov 2014 , 8 Jan 2015

View Random Gene

Category			(GIFtS: )
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes TMSB10 gene at Home site.

Version: 3.12.300 21 Jan 2015
hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4

GeneCards Plus

Advanced Search

Export list of displayed genes

TMSB10 Gene

Thymosin Beta 10

Aliases
for TMSB10 gene

Summaries
for TMSB10 gene

Genomic Views
for TMSB10 gene

Proteins
for TMSB10 gene

TMSB10 Human Recombinant Protein Products:

TMSB10 Antibody Products:

TMSB10 Assay Products:

Domains /
Families
for TMSB10 gene

Function
for TMSB10 gene

Localization
for TMSB10 gene

Pathways & Interactions
for TMSB10 gene

Drugs & Compounds
for TMSB10 gene

Transcripts
for TMSB10 gene

Expression
for TMSB10 gene

Orthologs
for TMSB10 gene

Paralogs
for TMSB10 gene

Genomic Variants
for TMSB10 gene

Disorders / Diseases
for TMSB10 gene

Publications
for TMSB10 gene

External Searches for TMSB10 gene

Genome Databases showing TMSB10 gene

Other Databases showing TMSB10 gene

Specialized Databases showing TMSB10 gene

Intellectual Property
for TMSB10 gene

Products
for TMSB10 gene

View Random Gene

GeneCards Plus

Advanced Search

Export list of displayed genes

TMSB10 Gene

Thymosin Beta 10

Aliasesfor TMSB10 gene

Summariesfor TMSB10 gene

Genomic Viewsfor TMSB10 gene

Proteinsfor TMSB10 gene

TMSB10 Human Recombinant Protein Products:

TMSB10 Antibody Products:

TMSB10 Assay Products:

Domains /Familiesfor TMSB10 gene

Functionfor TMSB10 gene

Localizationfor TMSB10 gene

Pathways & Interactionsfor TMSB10 gene

Drugs & Compoundsfor TMSB10 gene

Transcriptsfor TMSB10 gene

Expression for TMSB10 gene

Orthologsfor TMSB10 gene

Paralogsfor TMSB10 gene

Genomic Variantsfor TMSB10 gene

Disorders / Diseasesfor TMSB10 gene

Publicationsfor TMSB10 gene

External Searches for TMSB10 gene

Genome Databases showing TMSB10 gene

Other Databases showing TMSB10 gene

Specialized Databases showing TMSB10 gene

Intellectual Propertyfor TMSB10 gene

Productsfor TMSB10 gene

View Random Gene

Aliases
for TMSB10 gene

Summaries
for TMSB10 gene

Genomic Views
for TMSB10 gene

Proteins
for TMSB10 gene

Domains /
Families
for TMSB10 gene

Function
for TMSB10 gene

Localization
for TMSB10 gene

Pathways & Interactions
for TMSB10 gene

Drugs & Compounds
for TMSB10 gene

Transcripts
for TMSB10 gene

Expression
for TMSB10 gene

Orthologs
for TMSB10 gene

Paralogs
for TMSB10 gene

Genomic Variants
for TMSB10 gene

Disorders / Diseases
for TMSB10 gene

Publications
for TMSB10 gene

Intellectual Property
for TMSB10 gene

Products
for TMSB10 gene