TMSB10 Gene

Aliases
for TMSB10 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC02P085114 GC02P085426 GC02P085090 GC02P085107 GC02P085044 GC02P084986

Summaries
for TMSB10 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for TMSB10 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000002.11  NC_018913.2  NT_022184.16  

SwitchGear Promoter luciferase reporter plasmid: TMSB10 promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TMSB10

TMSB10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P085132:  view genomic region     (about GC identifiers)

Proteins
for TMSB10 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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Explore the universe of human proteins at neXtProt for TMSB10: NX_P63313

Explore proteomics data for TMSB10 at MOPED

Post-translational modifications: 

TMSB10 Human Recombinant Protein Products:

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	Browse Proteins at Cloud-Clone Corp.
	Search eBioscience for Proteins for TMSB10
	Search GeneTex for Proteins for TMSB10
	antibodies-online proteins for TMSB10 (10 products)
	Search antibodies-online for peptides for TMSB10

TMSB10 Antibody Products:

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TMSB10 Assay Products:

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	Search eBioscience for ELISAs for TMSB10
	antibodies-online kits for TMSB10 (30 products)

Domains /
Families
for TMSB10 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: P63313

Find genes that share domains with TMSB10           About GenesLikeMe

Function
for TMSB10 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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     Gene Ontology (GO): 1 molecular function term:    About this table

genOway: Develop your customized and physiologically relevant rodent model for TMSB10

miRNA Products:		miRTarBase miRNAs that target TMSB10: hsa-mir-17-5p (MIRT051009), hsa-mir-101-5p (MIRT038714), hsa-mir-615-3p (MIRT040459)
		Block miRNA regulation of human, mouse, rat TMSB10 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate TMSB10 (see all 9):
		hsa-miR-148b hsa-miR-27a hsa-miR-657 hsa-miR-128 hsa-miR-3681* hsa-miR-1301 hsa-miR-152 hsa-miR-27b
		SwitchGear 3'UTR luciferase reporter plasmid: TMSB10 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for TMSB10
		Predesigned siRNA for gene silencing in human, mouse, rat TMSB10

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for TMSB10

Clone Products:		OriGene clones in human, mouse for TMSB10 (see all 8) OriGene ORF clones in mouse, rat for TMSB10 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: TMSB10 (NM_021103)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMSB10
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMSB10

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for TMSB10
		Browse ESI BIO Cell Lines and PureStem Progenitors for TMSB10

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMSB10

Localization
for TMSB10 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
cytoskeleton	5
cytosol	3

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Gene Ontology (GO): 2 cellular component terms:    About this table

Pathways & Interactions
for TMSB10 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Gene Ontology (GO): 3 biological process terms:    About this table

Drugs & Compounds
for TMSB10 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for TMSB10 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for TMSB10 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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TMSB10 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GGGGAAATCG

About this image

Neural Tube (Nervous System)    fully expand to see all 3 entries
Spinal Ventral Columns
Limb (Muscoskeletal System)    fully expand to see all 2 entries
Prechondrocytic Mesenchymal Cells Zeugopod
Limb Bud
Ovary (Reproductive System)
Primary Oocyte Primary Follicle
Gonad
Primary Oocyte Primary Follicle
Bone (Muscoskeletal System)
Prechondrocytic Mesenchymal Cells Zeugopod

Primer Products:		OriGene qPCR primer pairs and template standards for TMSB10
		Pre-validated RT2 qPCR Primer Assay in human, mouse / rat TMSB10
		QuantiTect SYBR Green Assays in human, mouse, rat TMSB10
		QuantiFast Probe-based Assays in human, mouse, rat TMSB10

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMSB10

Orthologs
for TMSB10 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for TMSB10 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for TMSB10 gene

TMSB15B²  TMSB15A²  TMSB4Y²  TMSB4X²  

5 SIMAP similar genes for TMSB10 using alignment to 2 protein entries:     TYB10_HUMAN (see all proteins):

TMSB15A    TMSB15B    TMSB4X    TMSB4XP4    TMSB4Y

Find genes that share paralogs with TMSB10           About GenesLikeMe


3 Pseudogenes.org Pseudogenes for TMSB10
PGOHUM00000240566 PGOHUM00000235972 PGOHUM00000241657

Genomic Variants
for TMSB10 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for TMSB10 (see all 82)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1463951411,2	C	--	85130764(+)	ATAAGC/TGTGAT	1	--	us2k1		0	--	--	--	--
rs1900659981,2	C	--	85130917(+)	ACCCCA/GTCTCT	1	--	us2k1		0	--	--	--	--
rs101800661,2	C	--	85130921(+)	cgtctC/Ttacta	1	--	us2k1		0	--	--	--	--
rs67119421,2	C,F	--	85130945(+)	tagccG/Agacat	1	--	us2k1		1		NA	4
rs67120441,2	C	--	85131013(+)	aacccA/Gggagg	1	--	us2k1		0	--	--	--	--
rs124775391,2	H	--	85131095(+)	aaagaA/Gaaaaa	1	--	us2k1 trp3		0	--	--	--	--
rs67151261,2	C,F,A,H	--	85131170(+)	aaaaaG/Aaaaga	1	--	us2k1 trp3		9		NS EA NA WA CSA	719
rs1443429831,2	C	--	85131170(+)	AAAAA-/GAAAGA	1	--	us2k1		0	--	--	--	--
rs1443572001,2		--	85131197(+)	TGCCTC/TTTCTT	1	--	us2k1		0	--	--	--	--
rs1487381741,2		--	85131280(+)	ACAAGC/GCTATG	1	--	us2k1		0	--	--	--	--

HapMap Linkage Disequilibrium report for TMSB10 (85132749 - 85133799 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for TMSB10:    About this table    

Variant ID	Type	Subtype	PubMed ID
dgv4201n71	CNV	Loss	21882294

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing TMSB10

DNA2.0 Custom Variant and Variant Library Synthesis for TMSB10

Disorders / Diseases
for TMSB10 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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1 disease for TMSB10

Selected Novoseek inferred disease relationships for TMSB10 gene (see all 11)    About this table

Publications
for TMSB10 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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1. Sequence of a human kidney cDNA clone encoding thymosin beta 10. (PubMed id 3365256)^{1, 2, 3} McCreary V.... Toback F.G. (Biochem. Biophys. Res. Commun. 1988)
2. Thymosin beta 10 levels in developing human brain and its regulation by retinoic acid in the HTB-10 neuroblastoma. (PubMed id 2169566)^{1, 2, 9} Hall A.K.... Morgan J.I. (Brain Res. Mol. Brain Res. 1990)
3. Thymosin beta-10 expression in melanoma cell lines and melanocytic lesions: a new progression marker for human cutaneous melanoma. (PubMed id 8425765)^{1, 2, 9} Weterman M.A.... Bloemers H.P.J. (Int. J. Cancer 1993)
4. Thymosin beta-10 gene overexpression is a general event in human carcinogenesis. (PubMed id 10487837)^{1, 3, 9} Santelli G....Fusco A. (Am. J. Pathol. 1999)
5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
6. Localization of thymosin beta10 in breast cancer cells: relationship to actin cytoskeletal remodeling and cell motility. (PubMed id 16786322)^{1, 9} Maelan A.E....Larsson L.I. (Histochem. Cell Biol. 2007)
7. Expression of thymosin beta10 and its role in non-small cell lung cancer. (PubMed id 18789485)^{1, 9} Gu Y....Wang E. (Hum. Pathol. 2009)
8. The interaction between E-tropomodulin and thymosin beta-10 rescues tumor cells from thymosin beta-10 mediated apoptosis by restoring actin architecture. (PubMed id 14741341)^{1, 9} Rho S.B....Lee J.H. (FEBS Lett. 2004)
9. Thymosin beta-10 is aberrantly expressed in pancreatic cancer and induces JNK activation. (PubMed id 19194824)^{1, 9} Li M....Yao Q. (Cancer Invest. 2009)
10. The identification of apoptosis-related residues in human thymosin beta-10 by mutational analysis and computational modeling. (PubMed id 16012174)^{1, 9} Rho S.B....Lee J.H. (J. Biol. Chem. 2005)

External Searches for TMSB10 gene

Genome Databases showing TMSB10 gene

Other Databases showing TMSB10 gene

Specialized Databases showing TMSB10 gene

Products
for TMSB10 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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