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TMSB10 Gene

protein-coding   GIFtS: 54
GCID: GC02P085132

Thymosin Beta 10
  See related diseases
at
MalaCards
 

Aliases
for TMSB10 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Thymosin Beta 101 2     Migration-Inducing Protein 122
MIG122     Thymosin Beta-102
TB102     PTMB103
Migration-Inducing Gene 122     THYB103

External Ids:    HGNC: 118791   Entrez Gene: 91682   Ensembl: ENSG000000345107   OMIM: 1883995   UniProtKB: P633133   
ORGUL members:         

Export aliases for TMSB10 gene to outside databases

Previous GC identifers: GC02P085114 GC02P085426 GC02P085090 GC02P085107 GC02P085044 GC02P084986


Summaries
for TMSB10 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TMSB10 Gene:
TMSB10 (thymosin beta 10) is a protein-coding gene. Diseases associated with TMSB10 include middle ear cholesteatoma, and alk-positive anaplastic large cell lymphoma. GO annotations related to this gene include actin binding. An important paralog of this gene is TMSB15B.

UniProtKB/Swiss-Prot: TYB10_HUMAN, P63313
Function: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers
(G actin) and therefore inhibits actin polymerization (By similarity)

Gene Wiki entry for TMSB10 Gene


Genomic Views
for TMSB10 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NC_018913.2  NT_022184.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the TMSB10 gene promoter:
         p53   AP-1   p300   FOXO4   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TMSB10 promoter sequence
   Search Chromatin IP Primers for TMSB10

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TMSB10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p11.2   Ensembl cytogenetic band:  2p11.2   HGNC cytogenetic band: 2p11.2

TMSB10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMSB10 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P085132:  view genomic region     (about GC identifiers)

Start:
 85,132,749 bp from pter      End:
 85,133,799 bp from pter
Size:
 1,051 bases      Orientation:
 plus strand

Proteins
for TMSB10 gene

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TYB10_HUMAN, P63313 (See protein sequence)
Recommended Name: Thymosin beta-10  
Size: 44 amino acids; 5026 Da
Developmental stage: Found to decrease dramatically after birth
Sequence caution: Sequence=AAA36746.1; Type=Erroneous initiation; Sequence=AAC41691.1; Type=Erroneous initiation;
Secondary accessions: P13472 Q596K9

Explore the universe of human proteins at neXtProt for TMSB10: NX_P63313

Explore proteomics data for TMSB10 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys4, Lys15, Lys26, Lys32
  • Modification sites at PhosphoSitePlus

    • See TMSB10 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_066926.1  
    ENSEMBL proteins: 
     ENSP00000233143  

    TMSB10 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for TMSB10
    OriGene Protein Over-expression Lysate for TMSB10
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    OriGene Custom Protein Services for TMSB10
    GenScript Custom Purified and Recombinant Proteins Services for TMSB10
    Novus Biologicals TMSB10 Protein
    Novus Biologicals TMSB10 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    TMSB10 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for TMSB10 (Thymosin beta 10)
    OriGene Antibodies for TMSB10
    OriGene Custom Antibody Services for TMSB10
    Novus Biologicals TMSB10 Antibodies
    Abcam antibodies for TMSB10
    Browse Antibodies at Cloud-Clone Corp.
    Search ThermoFisher Antibodies for TMSB10
    LSBio Antibodies in human, mouse, rat for TMSB10

    TMSB10 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TMSB10
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TMSB10
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.

    Domains /
    Families
    for TMSB10 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus    		 2 InterPro protein domains:
     IPR001152 Thymosin_b4
     IPR016323 Thymosin_b4_metazoa

    Graphical View of Domain Structure for InterPro Entry P63313

    ProtoNet protein and cluster: P63313

    1 Blocks protein domain: IPB001152 Thymosin beta-4

    UniProtKB/Swiss-Prot: TYB10_HUMAN, P63313
    Similarity: Belongs to the thymosin beta family


    TMSB10 for domains           About GeneDecksing


    Function
    for TMSB10 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TYB10_HUMAN, P63313
    Function: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers
    (G actin) and therefore inhibits actin polymerization (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
         
    TMSB10 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TMSB10
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TMSB10

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TMSB10
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TMSB10

    miRNA
    Products:            		miRTarBase miRNAs that target TMSB10:
    hsa-mir-17-5p (MIRT051009), hsa-mir-101-5p (MIRT038714), hsa-mir-615-3p (MIRT040459)

    Block miRNA regulation of human, mouse, rat TMSB10 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TMSB10 (see all 9):
    hsa-miR-148b hsa-miR-27a hsa-miR-657 hsa-miR-128 hsa-miR-3681* hsa-miR-1301 hsa-miR-152 hsa-miR-27b
    SwitchGear 3'UTR luciferase reporter plasmid: TMSB10 3' UTR sequence
    Inhib. RNA
    Products:            		OriGene RNAi products in human, mouse, rat for TMSB10
    Predesigned siRNA for gene silencing in human, mouse, rat TMSB10

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for TMSB10

    Clone
    Products:             		 OriGene clones in human, mouse for TMSB10 (see all 8)
    OriGene ORF clones in mouse, rat for TMSB10
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TMSB10 (NM_021103)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMSB10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMSB10

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for TMSB10
    Browse ESI BIO Cell Lines and PureStem Progenitors for TMSB10 
    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMSB10


    Localization
    for TMSB10 gene

    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TYB10_HUMAN, P63313: Cytoplasm, cytoskeleton
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol3

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005856cytoskeleton IEA--

    TMSB10 for ontologies           About GeneDecksing


    Pathways & Interactions
    for TMSB10 gene

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

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        Pathway & Disease-focused RT2 Profiler PCR Array including TMSB10: 
              Nephrotoxicity in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for TMSB10

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    Selected Interacting proteins for TMSB10 (P633133 ENSP000002331434) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TMOD1P282893, ENSP000002593654I2D: score=1 STRING: ENSP00000259365
    FOSP011003, ENSP000003062454I2D: score=1 STRING: ENSP00000306245
    SUFUENSP000003589184STRING: ENSP00000358918
    UBCENSP000003448184STRING: ENSP00000344818
    POT1ENSP000003502494STRING: ENSP00000350249
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007010cytoskeleton organization ----
    GO:0030036actin cytoskeleton organization IEA--
    GO:0042989sequestering of actin monomers IEA--

    TMSB10 for ontologies           About GeneDecksing



    Drugs & Compounds
    for TMSB10 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TMSB10 (TYB10)

    2 Novoseek inferred chemical compound relationships for TMSB10 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoic acid 28.8 2 2169566 (2)
    vegf 23.9 9 11156961 (3), 16496302 (2), 12914774 (1), 18854659 (1)



    TMSB10 for compounds           About GeneDecksing



    Transcripts
    for TMSB10 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TMSB10 gene: 
    NM_021103.3  

    Unigene Cluster for TMSB10:

    Thymosin beta 10
    Hs.446574  [show with all ESTs]
    Unigene Representative Sequence: BQ276852
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000233143(uc002sow.1)
    miRNA
    Products:             		 Block miRNA regulation of human, mouse, rat TMSB10 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TMSB10 (see all 9):
    hsa-miR-148b hsa-miR-27a hsa-miR-657 hsa-miR-128 hsa-miR-3681* hsa-miR-1301 hsa-miR-152 hsa-miR-27b
    SwitchGear 3'UTR luciferase reporter plasmid: TMSB10 3' UTR sequence
    Inhib. RNA
    Products:             		OriGene RNAi products in human, mouse, rat for TMSB10
    Predesigned siRNA for gene silencing in human, mouse, rat TMSB10
    Clone
    Products:             		 OriGene clones in human, mouse for TMSB10 (see all 8)
    OriGene ORF clones in mouse, rat for TMSB10
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TMSB10 (NM_021103)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMSB10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMSB10
    Primer
    Products:            		OriGene qPCR primer pairs and template standards for TMSB10
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat TMSB10
      QuantiTect SYBR Green Assays in human, mouse, rat TMSB10
      QuantiFast Probe-based Assays in human, mouse, rat TMSB10

    Additional mRNA sequence: 

    AK130949.1 AK311952.1 AY453400.1 BC016025.1 BC016731.1 BC107889.1 M20259.1 M92381.1 
    S54005.1 

    Selected DOTS entries (see all 41):

    DT.455409  DT.99926681  DT.99926733  DT.121001526  DT.100701944  DT.95219544  DT.101985573  DT.121001374 
    DT.95222543  DT.100701960  DT.99994789  DT.100848983  DT.100757256  DT.97760238  DT.101985574  DT.121001398 
    DT.92466041  DT.92466043  DT.100701909  DT.100701911  DT.121001388  DT.121001422  DT.95221885  DT.100701924 

    Selected AceView cDNA sequences (see all 1350):

    BQ083925 AA640068 BQ222149 BM460102 AU103130 AI499000 CB110632 T27818 
    CB156637 BU789133 BE909902 BF726605 CB119763 F24712 AW163694 BP428861 
    BM842129 CB127872 AJ709478 AI081185 AU103129 CB111668 BM800103 BQ672252 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for TMSB10    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c · 3d
    SP1:                          -                     
    SP2:                                                
    SP3:                          -                     


    ECgene alternative splicing isoforms for TMSB10

    Expression
    for TMSB10 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    TMSB10 expression in normal human tissues (normalized intensities)      TMSB10 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGGAAATCG
    TMSB10 Expression
    About this image


    TMSB10 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Spinal Ventral Columns
     
     Limb (Muscoskeletal System)    fully expand to see all 2 entries
             Prechondrocytic Mesenchymal Cells Zeugopod
             Limb Bud
     
     Ovary (Reproductive System)
             Primary Oocyte Primary Follicle
     
     Gonad
             Primary Oocyte Primary Follicle
     
     Bone (Muscoskeletal System)
             Prechondrocytic Mesenchymal Cells Zeugopod
    TMSB10 Protein expression data from MOPED1, PaxDb2 and MaxQB3:     About this image

    TMSB10 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.446574
        Pathway & Disease-focused RT2 Profiler PCR Array including TMSB10: 
              Nephrotoxicity in human mouse rat

    Primer
    Products:    		OriGene qPCR primer pairs and template standards for TMSB10
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat TMSB10
    QuantiTect SYBR Green Assays in human, mouse, rat TMSB10
    QuantiFast Probe-based Assays in human, mouse, rat TMSB10
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMSB10

    Orthologs
    for TMSB10 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TMSB10 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Tmsb105 thymosin, beta 10   --   6 (32.35 cM) 72957347 
    chicken
    (Gallus gallus)    		 Aves TMSB106
    		 thymosin beta 10
    		 73(a)
    		 1 ↔ 1
    		 13(13676142-13677119) ENSGALG00000018624
    zebrafish
    (Danio rerio)    		 Actinopterygii tmsb6
    tmsb4x6
    (see all 3)    		 thymosin, beta 4 x
    (see all 3)    		 73(a)
    70(a)
    (see all 3)    		 many ↔ many
    many ↔ many
    (see all 3)    		 21(25782878-25786220) ENSDARG00000054911
    9(56198178-56199762) ENSDARG00000077777


    ENSEMBL Gene Tree for TMSB10 (if available)
    TreeFam Gene Tree for TMSB10 (if available)

    Paralogs
    for TMSB10 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for TMSB10 gene
    TMSB15B2  TMSB15A2  TMSB4Y2  TMSB4X2  
    5 SIMAP similar genes for TMSB10 using alignment to 2 protein entries:     TYB10_HUMAN (see all proteins):
    TMSB15A    TMSB15B    TMSB4X    TMSB4XP4    TMSB4Y

    TMSB10 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for TMSB10
    PGOHUM00000240566 PGOHUM00000235972 PGOHUM00000241657


    Genomic Variants
    for TMSB10 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for TMSB10 (see all 82)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1463951411,2
    		C--85130764(+) ATAAGC/TGTGAT 1 -- us2k10--------
    rs1900659981,2
    		C--85130917(+) ACCCCA/GTCTCT 1 -- us2k10--------
    rs101800661,2
    		C--85130921(+) cgtctC/Ttacta 1 -- us2k10--------
    rs67119421,2
    		C,F--85130945(+) tagccG/Agacat 1 -- us2k11Minor allele frequency- A:0.50NA 4
    rs67120441,2
    		C--85131013(+) aacccA/Gggagg 1 -- us2k10--------
    rs124775391,2
    		H--85131095(+) aaagaA/Gaaaaa 1 -- us2k1 trp30--------
    rs67151261,2
    		C,F,A,H--85131170(+) aaaaaG/Aaaaga 1 -- us2k1 trp39Minor allele frequency- A:0.12NS EA NA WA CSA 719
    rs1443429831,2
    		C--85131170(+) AAAAA-/GAAAGA 1 -- us2k10--------
    rs1443572001,2
    		--85131197(+) TGCCTC/TTTCTT 1 -- us2k10--------
    rs1487381741,2
    		--85131280(+) ACAAGC/GCTATG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TMSB10 (85132749 - 85133799 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for TMSB10:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv4201n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TMSB10
    DNA2.0 Custom Variant and Variant Library Synthesis for TMSB10

    Disorders / Diseases
    for TMSB10 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus    		 OMIM gene information: 188399    OMIM disorders: --

    Selected diseases for TMSB10 (see all 28):    About MalaCards
    middle ear cholesteatoma    alk-positive anaplastic large cell lymphoma    chronic graft versus host disease    anaplastic large cell lymphoma
    interstitial lung disease    cholesteatoma    chorea    goiter
    graft versus host disease    papillary thyroid carcinoma    scleroderma    choroiditis
    ovarian cancer    thyroiditis    neuroblastoma    pancreatitis
    melanoma    pancreatic cancer    hypoxia    atherosclerosis

    1 disease from the University of Copenhagen DISEASES database for TMSB10:
    Tuberculosis

    TMSB10 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for TMSB10 gene (see all 11)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    thyroid carcinoma 48.1 2 15254683 (1), 10487837 (1)
    neoplastic transformation 33.7 1 9485041 (1)
    pancreatic carcinoma 31 6 15983444 (1)
    goiter 26.9 3 10366416 (2)
    melanoma 15.7 4 8425765 (3)
    tumors 15 13 14989934 (2), 14975205 (2), 11956663 (1), 15983444 (1) (see all 7)
    cancer lung 15 4 18789485 (3)
    cancer 14.9 8 11709704 (1), 19909017 (1), 11710837 (1), 16786322 (1) (see all 7)
    breast cancer 13.3 3 16786322 (2), 8912542 (1)
    ovarian cancer 4.89 6 11709704 (2)


    Export disorders for TMSB10 gene to outside databases

    Publications
    for TMSB10 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for TMSB10 gene, integrated from 10 sources (see all 81):
    (articles sorted by number of sources associating them with TMSB10)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Sequence of a human kidney cDNA clone encoding thymosin beta 10. (PubMed id 3365256)1, 2, 3 McCreary V.... Toback F.G. (Biochem. Biophys. Res. Commun. 1988)
    2. Thymosin beta 10 levels in developing human brain and its regulation by retinoic acid in the HTB-10 neuroblastoma. (PubMed id 2169566)1, 2, 9 Hall A.K.... Morgan J.I. (Brain Res. Mol. Brain Res. 1990)
    3. Thymosin beta-10 expression in melanoma cell lines and melanocytic lesions: a new progression marker for human cutaneous melanoma. (PubMed id 8425765)1, 2, 9 Weterman M.A.... Bloemers H.P.J. (Int. J. Cancer 1993)
    4. Thymosin beta-10 gene overexpression is a general event in human carcinogenesis. (PubMed id 10487837)1, 3, 9 Santelli G....Fusco A. (Am. J. Pathol. 1999)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Localization of thymosin beta10 in breast cancer cells: relationship to actin cytoskeletal remodeling and cell motility. (PubMed id 16786322)1, 9 Maelan A.E....Larsson L.I. (Histochem. Cell Biol. 2007)
    7. Expression of thymosin beta10 and its role in non-small cell lung cancer. (PubMed id 18789485)1, 9 Gu Y....Wang E. (Hum. Pathol. 2009)
    8. The interaction between E-tropomodulin and thymosin beta-10 rescues tumor cells from thymosin beta-10 mediated apoptosis by restoring actin architecture. (PubMed id 14741341)1, 9 Rho S.B....Lee J.H. (FEBS Lett. 2004)
    9. Thymosin beta-10 is aberrantly expressed in pancreatic cancer and induces JNK activation. (PubMed id 19194824)1, 9 Li M....Yao Q. (Cancer Invest. 2009)
    10. The identification of apoptosis-related residues in human thymosin beta-10 by mutational analysis and computational modeling. (PubMed id 16012174)1, 9 Rho S.B....Lee J.H. (J. Biol. Chem. 2005)

    External Searches for TMSB10 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing TMSB10 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 9168 HGNC: 11879 AceView: TMSB10 Ensembl:ENSG00000034510 euGenes: HUgn9168
    ECgene: TMSB10 H-InvDB: TMSB10

    Other Databases showing TMSB10 gene

    (According to HUGE)
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    Specialized Databases showing TMSB10 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TMSB10 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TMSB10 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for TMSB10 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus    		Patent Information for TMSB10 gene:
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