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Aliases for TMSB10 Gene

Aliases for TMSB10 Gene

  • Thymosin Beta 10 2 3 5
  • Migration-Inducing Protein 12 3
  • Migration-Inducing Gene 12 3
  • Thymosin Beta-10 3
  • PTMB10 4
  • THYB10 4
  • MIG12 3
  • TB10 3

External Ids for TMSB10 Gene

Previous GeneCards Identifiers for TMSB10 Gene

  • GC02P085114
  • GC02P085426
  • GC02P085090
  • GC02P085107
  • GC02P085044
  • GC02P084986
  • GC02P085132

Summaries for TMSB10 Gene

GeneCards Summary for TMSB10 Gene

TMSB10 (Thymosin Beta 10) is a Protein Coding gene. Diseases associated with TMSB10 include Primary Bacterial Infectious Disease. GO annotations related to this gene include actin binding and actin monomer binding. An important paralog of this gene is TMSB4X.

UniProtKB/Swiss-Prot for TMSB10 Gene

  • Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity).

Gene Wiki entry for TMSB10 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMSB10 Gene

Genomics for TMSB10 Gene

Regulatory Elements for TMSB10 Gene

Enhancers for TMSB10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F085536 0.9 FANTOM5 ENCODE 4.7 +634.1 634136 6.9 CREB3L1 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 VAMP8 GGCX SH2D6 CAPG C2orf68 USP39 RN7SL251P RNU7-64P SNORD94 TMSB10
GH02F085550 1.3 Ensembl ENCODE 4.7 +644.9 644867 4.0 ELF3 HDGF PKNOX1 ARID4B SIN3A ZNF48 DNMT3B RAD21 RFX5 RARA USP39 GGCX VAMP8 CAPG SH2D6 TGOLN2 TMEM150A RN7SL251P RNU7-64P ELMOD3
GH02F085545 0.6 ENCODE 4.7 +640.9 640928 1.2 CTCF TBL1XR1 CHD7 THRB ZNF48 DNMT3B ZNF121 POLR2A NCOR1 TRIM24 USP39 GGCX C2orf68 CAPG SH2D6 TMEM150A RN7SL251P RNU7-64P VAMP8 TMSB10
GH02F085547 0.6 ENCODE 4.7 +642.4 642408 0.2 PAF1 POLR2A NR2F1 CHD7 NR2F6 CAPG SH2D6 USP39 TMEM150A RN7SL251P RNU7-64P TMSB10 GC02P085546 GGCX
GH02F085563 0.6 Ensembl ENCODE 4.6 +658.6 658576 1.2 ATF1 NFRKB PTRF IRF9 STAT2 PRDM10 TRIM24 CREM STAT1 RNF2 VAMP5 C2orf68 TMEM150A USP39 MAT2A CAPG SH2D6 ELMOD3 RETSAT VAMP8
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around TMSB10 on UCSC Golden Path with GeneCards custom track

Promoters for TMSB10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000593600 575 3201 HDGF CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF2 SLC30A9 ZNF143 ZNF207

Genomic Location for TMSB10 Gene

Chromosome:
2
Start:
84,905,625 bp from pter
End:
84,906,675 bp from pter
Size:
1,051 bases
Orientation:
Plus strand

Genomic View for TMSB10 Gene

Genes around TMSB10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMSB10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMSB10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMSB10 Gene

Proteins for TMSB10 Gene

  • Protein details for TMSB10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P63313-TYB10_HUMAN
    Recommended name:
    Thymosin beta-10
    Protein Accession:
    P63313
    Secondary Accessions:
    • P13472
    • Q596K9

    Protein attributes for TMSB10 Gene

    Size:
    44 amino acids
    Molecular mass:
    5026 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAA36746.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAC41691.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for TMSB10 Gene

Post-translational modifications for TMSB10 Gene

  • Ubiquitination at Lys 32
  • Modification sites at PhosphoSitePlus

Other Protein References for TMSB10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMSB10 Gene

Domains & Families for TMSB10 Gene

Protein Domains for TMSB10 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for TMSB10 Gene

Graphical View of Domain Structure for InterPro Entry

P63313

UniProtKB/Swiss-Prot:

TYB10_HUMAN :
  • Belongs to the thymosin beta family.
Family:
  • Belongs to the thymosin beta family.
genes like me logo Genes that share domains with TMSB10: view

No data available for Gene Families for TMSB10 Gene

Function for TMSB10 Gene

Molecular function for TMSB10 Gene

UniProtKB/Swiss-Prot Function:
Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity).

Gene Ontology (GO) - Molecular Function for TMSB10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003785 actin monomer binding IBA --
GO:0005515 protein binding IPI 21044950
genes like me logo Genes that share ontologies with TMSB10: view
genes like me logo Genes that share phenotypes with TMSB10: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TMSB10

miRNA for TMSB10 Gene

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMSB10 Gene

Localization for TMSB10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMSB10 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMSB10 Gene COMPARTMENTS Subcellular localization image for TMSB10 gene
Compartment Confidence
cytoskeleton 5
cytosol 3
extracellular 1

Gene Ontology (GO) - Cellular Components for TMSB10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,IBA --
GO:0005856 cytoskeleton IEA --
GO:0031941 filamentous actin IBA --
genes like me logo Genes that share ontologies with TMSB10: view

Pathways & Interactions for TMSB10 Gene

SuperPathways for TMSB10 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMSB10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007015 actin filament organization IEA --
GO:0030036 actin cytoskeleton organization IBA --
GO:0042989 sequestering of actin monomers IBA --
genes like me logo Genes that share ontologies with TMSB10: view

No data available for Pathways by source and SIGNOR curated interactions for TMSB10 Gene

Drugs & Compounds for TMSB10 Gene

(2) Additional Compounds for TMSB10 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TMSB10: view

Transcripts for TMSB10 Gene

mRNA/cDNA for TMSB10 Gene

(1) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(1350) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMSB10 Gene

Thymosin beta 10:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMSB10 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c · 3d
SP1: -
SP2:
SP3: -

Relevant External Links for TMSB10 Gene

GeneLoc Exon Structure for
TMSB10
ECgene alternative splicing isoforms for
TMSB10

Expression for TMSB10 Gene

mRNA expression in normal human tissues for TMSB10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TMSB10 Gene

This gene is overexpressed in CD4 Tcells (8.1) and Amniocyte (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TMSB10 Gene



Protein tissue co-expression partners for TMSB10 Gene

NURSA nuclear receptor signaling pathways regulating expression of TMSB10 Gene:

TMSB10

SOURCE GeneReport for Unigene cluster for TMSB10 Gene:

Hs.446574
genes like me logo Genes that share expression patterns with TMSB10: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TMSB10 Gene

Orthologs for TMSB10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMSB10 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia TMSB10 35
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMSB10 35
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm9844 35
  • 100 (a)
OneToMany
Tmsb10 35
  • 100 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia TMSB10 35
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMSB10 35
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMSB10 35
  • 73 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii tmsb 35
  • 73 (a)
ManyToMany
tmsb4x 35
  • 70 (a)
ManyToMany
si:ch211-11c15.3 35
  • 69 (a)
ManyToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4131 34
Species where no ortholog for TMSB10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMSB10 Gene

ENSEMBL:
Gene Tree for TMSB10 (if available)
TreeFam:
Gene Tree for TMSB10 (if available)

Paralogs for TMSB10 Gene

Paralogs for TMSB10 Gene

(5) SIMAP similar genes for TMSB10 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for TMSB10 Gene

genes like me logo Genes that share paralogs with TMSB10: view

Variants for TMSB10 Gene

Sequence variations from dbSNP and Humsavar for TMSB10 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs10180066 -- 84,903,797(+) cgtct(C/T)tacta intron-variant, upstream-variant-2KB
rs10182842 -- 84,904,050(+) AGAAA(A/G)AAAAA intron-variant, upstream-variant-2KB
rs1050802 -- 84,906,566(+) GGTCT(C/G/T)TGAAG intron-variant, utr-variant-3-prime
rs1050866 -- 84,906,601(+) AAATT(C/T)TCCGG intron-variant, utr-variant-3-prime
rs1052260 -- 84,906,846(-) ACAAG(C/T)CATGA nc-transcript-variant, downstream-variant-500B

Variation tolerance for TMSB10 Gene

Residual Variation Intolerance Score: 56.5% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMSB10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMSB10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TMSB10 Gene

Disorders for TMSB10 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TMSB10 Gene - From: DISEASES

Disorder Aliases PubMed IDs
primary bacterial infectious disease
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TMSB10

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMSB10
genes like me logo Genes that share disorders with TMSB10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TMSB10 Gene

Publications for TMSB10 Gene

  1. Thymosin beta-10 gene overexpression is a general event in human carcinogenesis. (PMID: 10487837) Santelli G. … Fusco A. (Am. J. Pathol. 1999) 2 3 22 64
  2. Thymosin beta-10 expression in melanoma cell lines and melanocytic lesions: a new progression marker for human cutaneous melanoma. (PMID: 8425765) Weterman M.A. … Bloemers H.P.J. (Int. J. Cancer 1993) 3 4 22 64
  3. Thymosin beta 10 levels in developing human brain and its regulation by retinoic acid in the HTB-10 neuroblastoma. (PMID: 2169566) Hall A.K. … Morgan J.I. (Brain Res. Mol. Brain Res. 1990) 3 4 22 64
  4. Sequence of a human kidney cDNA clone encoding thymosin beta 10. (PMID: 3365256) McCreary V. … Toback F.G. (Biochem. Biophys. Res. Commun. 1988) 2 3 4 64
  5. Expression of thymosin beta10 and its role in non-small cell lung cancer. (PMID: 18789485) Gu Y. … Wang E. (Hum. Pathol. 2009) 3 22 64

Products for TMSB10 Gene

Sources for TMSB10 Gene

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