Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TMSB10 Gene

Aliases for TMSB10 Gene

  • Thymosin Beta 10 2 3
  • Migration-Inducing Protein 12 3
  • Migration-Inducing Gene 12 3
  • Thymosin Beta-10 3
  • PTMB10 4
  • THYB10 4
  • MIG12 3
  • TB10 3

External Ids for TMSB10 Gene

Summaries for TMSB10 Gene

GeneCards Summary for TMSB10 Gene

TMSB10 is a Protein Coding gene. Diseases associated with TMSB10 include chronic graft versus host disease. GO annotations related to this gene include actin binding. An important paralog of this gene is TMSB15B.

UniProtKB/Swiss-Prot for TMSB10 Gene

  • Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity).

Gene Wiki entry for TMSB10 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMSB10 Gene

Genomics for TMSB10 Gene

Genomic Location for TMSB10 Gene

Start:
84,905,625 bp from pter
End:
84,906,675 bp from pter
Size:
1,051 bases
Orientation:
Plus strand

Genomic View for TMSB10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMSB10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMSB10 Gene

Regulatory Elements for TMSB10 Gene

Proteins for TMSB10 Gene

  • Protein details for TMSB10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P63313-TYB10_HUMAN
    Recommended name:
    Thymosin beta-10
    Protein Accession:
    P63313
    Secondary Accessions:
    • P13472
    • Q596K9

    Protein attributes for TMSB10 Gene

    Size:
    44 amino acids
    Molecular mass:
    5026 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAA36746.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAC41691.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for TMSB10 Gene

Proteomics data for TMSB10 Gene at MOPED

Post-translational modifications for TMSB10 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys4, Lys15, Lys26, and Lys32

Other Protein References for TMSB10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMSB10 Gene

Domains for TMSB10 Gene

Protein Domains for TMSB10 Gene

UniProtKB/Swiss-Prot:

TYB10_HUMAN
Family:
  • Belongs to the thymosin beta family.:
    • P63313
genes like me logo Genes that share domains with TMSB10: view

No data available for Gene Families for TMSB10 Gene

Function for TMSB10 Gene

Molecular function for TMSB10 Gene

UniProtKB/Swiss-Prot Function: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity).

Gene Ontology (GO) - Molecular Function for TMSB10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding --
GO:0003785 actin monomer binding IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TMSB10: view

miRNA for TMSB10 Gene

miRTarBase miRNAs that target TMSB10

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TMSB10 Gene

Localization for TMSB10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMSB10 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMSB10 Gene COMPARTMENTS Subcellular localization image for TMSB10 gene
Compartment Confidence
cytoskeleton 5
cytosol 3

Gene Ontology (GO) - Cellular Components for TMSB10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with TMSB10: view

Pathways for TMSB10 Gene

SuperPathways for TMSB10 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMSB10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007010 cytoskeleton organization --
GO:0007015 actin filament organization IEA --
GO:0030036 actin cytoskeleton organization --
GO:0042989 sequestering of actin monomers IEA --
genes like me logo Genes that share ontologies with TMSB10: view

No data available for Pathways by source for TMSB10 Gene

Compounds for TMSB10 Gene

(2) Novoseek inferred chemical compound relationships for TMSB10 Gene

Compound -log(P) Hits PubMed IDs
retinoic acid 28.8 2
vegf 23.9 7
genes like me logo Genes that share compounds with TMSB10: view

Transcripts for TMSB10 Gene

mRNA/cDNA for TMSB10 Gene

(1) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(1350) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMSB10 Gene

Thymosin beta 10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMSB10 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c · 3d
SP1: -
SP2:
SP3: -

Relevant External Links for TMSB10 Gene

GeneLoc Exon Structure for
TMSB10
ECgene alternative splicing isoforms for
TMSB10

Expression for TMSB10 Gene

mRNA expression in normal human tissues for TMSB10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TMSB10 Gene

SOURCE GeneReport for Unigene cluster for TMSB10 Gene Hs.446574

genes like me logo Genes that share expressions with TMSB10: view

Orthologs for TMSB10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMSB10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMSB10 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMSB10 37
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMSB10 37
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm9844 37
  • 100 (a)
OneToMany
Tmsb10 16
Tmsb10 37
  • 100 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia TMSB10 37
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMSB10 37
  • 73 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4131 36
zebrafish
(Danio rerio)
Actinopterygii si:ch211-11c15.3 37
  • 69 (a)
ManyToMany
tmsb 37
  • 73 (a)
ManyToMany
tmsb4x 37
  • 70 (a)
ManyToMany
Species with no ortholog for TMSB10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMSB10 Gene

ENSEMBL:
Gene Tree for TMSB10 (if available)
TreeFam:
Gene Tree for TMSB10 (if available)

Paralogs for TMSB10 Gene

Paralogs for TMSB10 Gene

Selected SIMAP similar genes for TMSB10 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for TMSB10 Gene

genes like me logo Genes that share paralogs with TMSB10: view

Variants for TMSB10 Gene

Sequence variations from dbSNP and Humsavar for TMSB10 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs7148 -- 84,906,092(+) CAGGA(A/C/G)AAGAA synonymous-codon, missense, reference
rs12639 -- 84,906,071(+) AAGCT(G/T)AAGAA reference, synonymous-codon
rs1050802 -- 84,906,566(+) GGTCT(C/T)TGAAG utr-variant-3-prime
rs1050866 -- 84,906,601(+) AAATT(C/T)TCCGG utr-variant-3-prime
rs1052260 -- 84,906,846(-) ACAAG(C/T)CATGA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for TMSB10 Gene

Variant ID Type Subtype PubMed ID
dgv4201n71 CNV Loss 21882294

Relevant External Links for TMSB10 Gene

HapMap Linkage Disequilibrium report
TMSB10

Disorders for TMSB10 Gene

(1) University of Copenhagen DISEASES for TMSB10 Gene

(11) Novoseek inferred disease relationships for TMSB10 Gene

Disease -log(P) Hits PubMed IDs
thyroid carcinoma 48.1 2
neoplastic transformation 33.7 1
pancreatic carcinoma 31 1
goiter 26.9 2
melanoma 15.7 3
genes like me logo Genes that share disorders with TMSB10: view

No data available for UniProtKB/Swiss-Prot for TMSB10 Gene

Publications for TMSB10 Gene

  1. Thymosin beta-10 expression in melanoma cell lines and melanocytic lesions: a new progression marker for human cutaneous melanoma. (PMID: 8425765) Weterman M.A. … Bloemers H.P.J. (Int. J. Cancer 1993) 3 4 23
  2. Thymosin beta 10 levels in developing human brain and its regulation by retinoic acid in the HTB-10 neuroblastoma. (PMID: 2169566) Hall A.K. … Morgan J.I. (Brain Res. Mol. Brain Res. 1990) 3 4 23
  3. Thymosin beta-10 gene overexpression is a general event in human carcinogenesis. (PMID: 10487837) Santelli G. … Fusco A. (Am. J. Pathol. 1999) 2 3 23
  4. Sequence of a human kidney cDNA clone encoding thymosin beta 10. (PMID: 3365256) McCreary V. … Toback F.G. (Biochem. Biophys. Res. Commun. 1988) 2 3 4
  5. Expression of thymosin beta10 and its role in non-small cell lung cancer. (PMID: 18789485) Gu Y. … Wang E. (Hum. Pathol. 2009) 3 23

Products for TMSB10 Gene

Sources for TMSB10 Gene

Back to Top

Content