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TMPRSS9 Gene

protein-coding   GIFtS: 47
GCID: GC19P002389

Transmembrane Protease, Serine 9

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Transmembrane Protease, Serine 91 2     Transmembrane Serine Protease 92
Polyserase 11 2     EC 3.4.21.-3
Polyserine Protease 12 3     Polyserase-13
polyserase-12     Polyserase-I3
polyserase-I2     EC 3.4.218
Transmembrane Protease Serine 92     EC 3.4.21.48

External Ids:    HGNC: 300791   Entrez Gene: 3602002   Ensembl: ENSG000001782977   OMIM: 6104775   UniProtKB: Q7Z4103   

Export aliases for TMPRSS9 gene to outside databases

Previous GC identifers: GC19P002341 GC19P002342 GC19P002161


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TMPRSS9 Gene:
TMPRSS9 (transmembrane protease, serine 9) is a protein-coding gene. Diseases associated with TMPRSS9 include malaria. GO annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is PRSS46.

UniProtKB/Swiss-Prot: TMPS9_HUMAN, Q7Z410
Function: Serase-1 and serase-2 are serine proteases that hydrolyze the peptides N-t-Boc-Gln-Ala-Arg-AMC and
N-t-Boc-Gln-Gly-Arg-AMC. In contrast, N-t-Boc-Ala-Phe-Lys-AMC and N-t-Boc-Ala-Pro-Ala-AMC are not significantly
hydrolyzed




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NT_011295.12  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TMPRSS9 gene promoter:
         AREB6   ZID   YY1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMPRSS9 promoter sequence
   Search Chromatin IP Primers for TMPRSS9

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TMPRSS9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

TMPRSS9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMPRSS9 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P002389:  view genomic region     (about GC identifiers)

Start:
2,389,769 bp from pter      End:
2,426,237 bp from pter
Size:
36,469 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TMPS9_HUMAN, Q7Z410 (See protein sequence)
Recommended Name: Transmembrane protease serine 9  
Size: 1059 amino acids; 114021 Da
Sequence caution: Sequence=BAD18439.1; Type=Frameshift; Positions=776; Sequence=CAD35759.1; Type=Miscellaneous
discrepancy; Note=Aberrant splicing;
Secondary accessions: Q6ZND6 Q7Z411

Explore the universe of human proteins at neXtProt for TMPRSS9: NX_Q7Z410

Explore proteomics data for TMPRSS9 at MOPED

Post-translational modifications: 

  • Proteolytically cleaved to generate 3 independent serine protease chains. The cleaved chains may remain attached
    to the membrane thanks to disufide bonds. It is unclear whether cleavage always takes place1
  • Glycosylation2 at Asn547, Asn638, Asn663, Asn786
  • Selected DME Specific Peptides for TMPRSS9 (Q7Z410) (see all 7)
     GDSGGPL  WPWQVSL  VSWGIGC  CLISGWG 


    See TMPRSS9 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_892018.1  
    ENSEMBL proteins: 
     ENSP00000330264  

    TMPRSS9 Human Recombinant Protein Products:

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    TMPRSS9 Assay Products:

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    Cloud-Clone Corp. CLIAs for TMPRSS9


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TMPRSS: Serine peptidases / Transmembrane

    Selected InterPro protein domains (see all 6):
     IPR002172 LDrepeatLR_classA_rpt
     IPR001314 Peptidase_S1A
     IPR009003 Trypsin-like_Pept_dom
     IPR017324 Pept_S1A_polyserase-1
     IPR001254 Peptidase_S1

    Graphical View of Domain Structure for InterPro Entry Q7Z410

    ProtoNet protein and cluster: Q7Z410

    2 Blocks protein domains:
    IPB001254 Serine protease
    IPB002172 Low density lipoprotein-receptor


    UniProtKB/Swiss-Prot: TMPS9_HUMAN, Q7Z410
    Domain: The serine protease 1 and 2 domains are catalytically active, whereas the serine protease 3 domain lacks
    the essential Ser residue of the catalytic triad at position 1009 and is predicted to be inactive
    Similarity: Belongs to the peptidase S1 family
    Similarity: Contains 1 LDL-receptor class A domain
    Similarity: Contains 3 peptidase S1 domains


    TMPRSS9 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TMPS9_HUMAN, Q7Z410
    Function: Serase-1 and serase-2 are serine proteases that hydrolyze the peptides N-t-Boc-Gln-Ala-Arg-AMC and
    N-t-Boc-Gln-Gly-Arg-AMC. In contrast, N-t-Boc-Ala-Phe-Lys-AMC and N-t-Boc-Ala-Pro-Ala-AMC are not significantly
    hydrolyzed
    Enzyme regulation: Inhibited by serine protease inhibitors PMSF and 4-(2-aminoethyl)benzenesulfonyl fluoride, but
    not by EDTA

         Enzyme Numbers (IUBMB): EC 3.4.21.42 EC 3.4.212 EC 3.4.21.-1

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004252serine-type endopeptidase activity IEA--
    GO:0005515protein binding ----
         
    TMPRSS9 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for TMPRSS9:
     Decreased cell number and incr  Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TMPRSS9
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMPRSS9


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TMPS9_HUMAN, Q7Z410: Cell membrane; Single-pass type II membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    endoplasmic reticulum1
    extracellular1
    lysosome1
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral component of plasma membrane IEA--

    TMPRSS9 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TMPRSS9
    Interactions:

        Search GeneGlobe Interaction Network for TMPRSS9

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    Selected Interacting proteins for TMPRSS9 (ENSP000003302644) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NFKBIAENSP000002167974STRING: ENSP00000216797
    NFIL3ENSP000002976894STRING: ENSP00000297689
    ACVR2AENSP000002414164STRING: ENSP00000241416
    ACVR2BENSP000003403614STRING: ENSP00000340361
    HIVEP1ENSP000003686984STRING: ENSP00000368698
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis ----

    TMPRSS9 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TMPRSS9 (TMPS9)

    1 Novoseek inferred chemical compound relationship for TMPRSS9 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    serine 55.7 14 12886014 (3), 16566820 (2), 16872279 (1), 15536082 (1) (see all 5)



    TMPRSS9 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TMPRSS9 gene: 
    NM_182973.1  

    Unigene Cluster for TMPRSS9:

    Transmembrane protease, serine 9
    Hs.465560  [show with all ESTs]
    Unigene Representative Sequence: AJ488946
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000395264(uc002lvv.1) ENST00000332578(uc010xgx.2) ENST00000592650
    ENST00000587863
    miRNA
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat TMPRSS9
      QuantiFast Probe-based Assays in human, mouse, rat TMPRSS9

    Additional mRNA sequence: 

    AB109390.1 AJ488946.1 AJ488947.1 AK131261.1 

    6 DOTS entries:

    DT.40114913  DT.101980088  DT.304152  DT.75129846  DT.91926971  DT.121414400 

    16 AceView cDNA sequences:

    AJ488947 AJ488946 NM_182973 BX405533 C16607 BI834360 AK131261 BF815884 
    C16606 BE085302 BX109239 AA702657 BI521588 AI032668 BE085224 BF745897 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TMPRSS9 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGATGCATT
    TMPRSS9 Expression
    About this image

    TMPRSS9 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TMPRSS9 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.465560

    UniProtKB/Swiss-Prot: TMPS9_HUMAN, Q7Z410
    Tissue specificity: Expressed in fetal human tissues, such as kidney, liver, lung and brain, and in a variety of
    tumor cell lines. Weakly expressed in adult tissues including skeletal muscle, liver, placenta and heart

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TMPRSS9 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tmprss91 , 5 transmembrane protease, serine 91, 5 78.99(n)1
    79.87(a)1
      10 (39.72 cM)5
    4324781  NM_001081688.21  NP_001075157.21 
     808798165 
    chicken
    (Gallus gallus)
    Aves TMPRSS91 transmembrane protease, serine 9 67.03(n)
    64.53(a)
      428320  XM_425880.4  XP_425880.4 
    African clawed frog
    (Xenopus laevis)
    Amphibia U81290.12   -- 74.48(n)    U81290.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tmprss91 transmembrane protease, serine 9 50.98(n)
    42.92(a)
      562051  XM_001922676.4  XP_001922711.4 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG137446
    CG81706
    --
    26(a)
    15(a)
    many → 1
    many → 1
    2R(4902011-4904184)
    2R(4906530-4918546)
    worm
    (Caenorhabditis elegans)
    Secernentea try-16
    Protein TRY-1 (try-1) mRNA, complete cds
    32(a)
    1 ↔ 1
    II(4948154-4949486) WBGene00006619


    ENSEMBL Gene Tree for TMPRSS9 (if available)
    TreeFam Gene Tree for TMPRSS9 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TMPRSS9 gene
    PRSS462  PRSS482  PRSS222  PRSS272  PRSS212  PRSS452  TPSG12  TPSD12  
    PRSS382  TPSAB12  PRSS532  PRSS502  PRSS422  PRSS362  PRSS332  PRSS82  
    TPSB22  
    Selected SIMAP similar genes for TMPRSS9 using alignment to 1 protein entry:     TMPS9_HUMAN(see all similar genes):
    serase-1B    PRSS22    PRSS27    CTRB1    CTRB2    PROC
    PRSS1    CELA2A    CTRL    PRSS2    TRY8    MGC52282
    TMPRSS3    KLK7    PRSS21    KLK8    PRSS3    PRSS48

    TMPRSS9 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TMPRSS9 (see all 1340)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs729714041,2
    C,F--2387907(+) GGGCAG/AGGGAG 1 -- us2k15Minor allele frequency- A:0.07CSA WA NA EA 360
    rs129724341,2
    C--2387912(+) GGGGAG/AGGAGG 1 -- us2k1 tfbs3 trp36Minor allele frequency- A:0.25NA EA 248
    rs1483160451,2
    C--2387932(+) AGTCCC/TTCCAG 1 -- us2k10--------
    rs1120600231,2
    C,F--2388008(+) ATCTCT/CTTTGA 1 -- us2k12Minor allele frequency- C:0.08CSA WA 120
    rs129813561,2
    C,F,H--2388079(+) CTTTGC/ATGCAC 1 -- us2k114Minor allele frequency- A:0.23NS EA NA WA CSA 765
    rs1849665161,2
    --2388087(+) CACCTC/TCCTTC 1 -- us2k10--------
    rs1414784101,2
    C--2388128(+) CTCACA/GCCGGT 1 -- us2k10--------
    rs1886360701,2
    --2388172(+) ATCGCA/GTGAGG 1 -- us2k10--------
    rs1132791391,2
    C,F--2388242(+) ATTAGC/TTGGGC 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs1474444621,2
    --2388340(+) GATCAC/TACCAT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TMPRSS9 (2389769 - 2426237 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for TMPRSS9 (see all 15):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1399285CNV Deletion17803354
    esv2677064CNV Deletion23128226
    esv2664636CNV Deletion23128226
    esv1707583CNV Deletion17803354
    esv272241CNV Insertion20981092
    nsv910655CNV Loss21882294
    dgv3637n71CNV Loss21882294
    nsv910660CNV Loss21882294
    dgv3638n71CNV Loss21882294
    nsv910665CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TMPRSS9
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610477    OMIM disorders: --

    1 disease for TMPRSS9:    
    About MalaCards
    malaria


    TMPRSS9 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TMPRSS9
    Human Genome Epidemiology (HuGE) Navigator: TMPRSS9 (1 document)

    Export disorders for TMPRSS9 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TMPRSS9 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with TMPRSS9)
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    1. Polyserase-I, a human polyprotease with the ability to generate independent serine protease domains from a single translation product. (PubMed id 12886014)1, 2, 3, 9 Cal S.... Lopez-Otin C. (Proc. Natl. Acad. Sci. U.S.A. 2003)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Serase-1B, a new splice variant of polyserase-1/TMPRSS9, activates urokinase-type plasminogen activator and the proteolytic activation is negatively regulated by glycosaminoglycans. (PubMed id 16872279)1, 9 Okumura Y.... Kido H. (Biochem. J. 2006)
    5. TMPRSS9 and GRIN2B are associated with neuroticism: a genome-wide association study in a European sample. (PubMed id 23229837)1 Aragam N....Liu X. (J. Mol. Neurosci. 2013)
    6. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (Nature 2004)
    7. Identification and characterization of human polyserase-3, a novel protein with tandem serine-protease domains in the same polypeptide chain. (PubMed id 16566820)9 Cal S.... Lopez-Otin C. (BMC Biochem. 2006)
    8. Expanding the complexity of the human degradome: polyserases and their tandem serine protease domains. (PubMed id 17485402)9 Cal S....Lopez-Otin C. (Front. Biosci. 2007)
    9. Human polyserase-2, a novel enzyme with three tandem serine protease domains in a single polypeptide chain. (PubMed id 15536082)9 Cal S....Lopez-Otin C. (J. Biol. Chem. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 360200 HGNC: 30079 AceView: TMPRSS9 Ensembl:ENSG00000178297 euGenes: HUgn360200
    ECgene: TMPRSS9 H-InvDB: TMPRSS9

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TMPRSS9 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TMPRSS9 gene:
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    GeneCards and IP:
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