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Aliases for TMPRSS9 Gene

Aliases for TMPRSS9 Gene

  • Transmembrane Protease, Serine 9 2 3 5
  • Polyserine Protease 1 3 4
  • Polyserase 1 2 3
  • Polyserase-1 3 4
  • Polyserase-I 3 4
  • Transmembrane Serine Protease 9 3
  • EC 3.4.21.4 63
  • EC 3.4.21.- 4
  • EC 3.4.21 63

External Ids for TMPRSS9 Gene

Previous GeneCards Identifiers for TMPRSS9 Gene

  • GC19P002341
  • GC19P002342
  • GC19P002161

Summaries for TMPRSS9 Gene

GeneCards Summary for TMPRSS9 Gene

TMPRSS9 (Transmembrane Protease, Serine 9) is a Protein Coding gene. GO annotations related to this gene include serine-type endopeptidase activity and serine-type peptidase activity. An important paralog of this gene is ST14.

UniProtKB/Swiss-Prot for TMPRSS9 Gene

  • Serase-1 and serase-2 are serine proteases that hydrolyze the peptides N-t-Boc-Gln-Ala-Arg-AMC and N-t-Boc-Gln-Gly-Arg-AMC. In contrast, N-t-Boc-Ala-Phe-Lys-AMC and N-t-Boc-Ala-Pro-Ala-AMC are not significantly hydrolyzed.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMPRSS9 Gene

Genomics for TMPRSS9 Gene

Regulatory Elements for TMPRSS9 Gene

Transcription factor binding sites by QIAGEN in the TMPRSS9 gene promoter:

Genomic Location for TMPRSS9 Gene

Chromosome:
19
Start:
2,385,235 bp from pter
End:
2,426,261 bp from pter
Size:
41,027 bases
Orientation:
Plus strand

Genomic View for TMPRSS9 Gene

Genes around TMPRSS9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMPRSS9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMPRSS9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMPRSS9 Gene

Proteins for TMPRSS9 Gene

  • Protein details for TMPRSS9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z410-TMPS9_HUMAN
    Recommended name:
    Transmembrane protease serine 9
    Protein Accession:
    Q7Z410
    Secondary Accessions:
    • Q6ZND6
    • Q7Z411

    Protein attributes for TMPRSS9 Gene

    Size:
    1059 amino acids
    Molecular mass:
    114021 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAD18439.1; Type=Frameshift; Positions=776; Evidence={ECO:0000305}; Sequence=CAD35759.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305};

neXtProt entry for TMPRSS9 Gene

Proteomics data for TMPRSS9 Gene at MOPED

Selected DME Specific Peptides for TMPRSS9 Gene

Post-translational modifications for TMPRSS9 Gene

  • Proteolytically cleaved to generate 3 independent serine protease chains. The cleaved chains may remain attached to the membrane thanks to disufide bonds. It is unclear whether cleavage always takes place.
  • Glycosylation at Asn 547, Asn 638, Asn 663, and Asn 786
  • Modification sites at PhosphoSitePlus

Other Protein References for TMPRSS9 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains & Families for TMPRSS9 Gene

Gene Families for TMPRSS9 Gene

Suggested Antigen Peptide Sequences for TMPRSS9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7Z410

UniProtKB/Swiss-Prot:

TMPS9_HUMAN :
  • The serine protease 1 and 2 domains are catalytically active, whereas the serine protease 3 domain lacks the essential Ser residue of the catalytic triad at position 1009 and is predicted to be inactive.
  • Belongs to the peptidase S1 family.
Domain:
  • The serine protease 1 and 2 domains are catalytically active, whereas the serine protease 3 domain lacks the essential Ser residue of the catalytic triad at position 1009 and is predicted to be inactive.
  • Contains 1 LDL-receptor class A domain.
  • Contains 3 peptidase S1 domains.
Family:
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with TMPRSS9: view

Function for TMPRSS9 Gene

Molecular function for TMPRSS9 Gene

UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by serine protease inhibitors PMSF and 4-(2-aminoethyl)benzenesulfonyl fluoride, but not by EDTA.
UniProtKB/Swiss-Prot Function:
Serase-1 and serase-2 are serine proteases that hydrolyze the peptides N-t-Boc-Gln-Ala-Arg-AMC and N-t-Boc-Gln-Gly-Arg-AMC. In contrast, N-t-Boc-Ala-Phe-Lys-AMC and N-t-Boc-Ala-Pro-Ala-AMC are not significantly hydrolyzed.

Enzyme Numbers (IUBMB) for TMPRSS9 Gene

genes like me logo Genes that share phenotypes with TMPRSS9: view

Animal Model Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMPRSS9 Gene

Localization for TMPRSS9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMPRSS9 Gene

Cell membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMPRSS9 Gene COMPARTMENTS Subcellular localization image for TMPRSS9 gene
Compartment Confidence
plasma membrane 4
endoplasmic reticulum 1
extracellular 1
lysosome 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for TMPRSS9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMPRSS9: view

Pathways & Interactions for TMPRSS9 Gene

SuperPathways for TMPRSS9 Gene

No Data Available

Interacting Proteins for TMPRSS9 Gene

Gene Ontology (GO) - Biological Process for TMPRSS9 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMPRSS9 Gene

Drugs & Compounds for TMPRSS9 Gene

(1) Drugs for TMPRSS9 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with TMPRSS9: view

Transcripts for TMPRSS9 Gene

Unigene Clusters for TMPRSS9 Gene

Transmembrane protease, serine 9:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMPRSS9 Gene

No ASD Table

Relevant External Links for TMPRSS9 Gene

GeneLoc Exon Structure for
TMPRSS9
ECgene alternative splicing isoforms for
TMPRSS9

Expression for TMPRSS9 Gene

mRNA expression in normal human tissues for TMPRSS9 Gene

mRNA differential expression in normal tissues according to GTEx for TMPRSS9 Gene

This gene is overexpressed in Testis (x8.1), Liver (x7.7), and Spleen (x4.2).

Protein differential expression in normal tissues from HIPED for TMPRSS9 Gene

This gene is overexpressed in Pancreatic juice (36.6) and Liver (30.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMPRSS9 Gene



SOURCE GeneReport for Unigene cluster for TMPRSS9 Gene Hs.465560

mRNA Expression by UniProt/SwissProt for TMPRSS9 Gene

Q7Z410-TMPS9_HUMAN
Tissue specificity: Expressed in fetal human tissues, such as kidney, liver, lung and brain, and in a variety of tumor cell lines. Weakly expressed in adult tissues including skeletal muscle, liver, placenta and heart.
genes like me logo Genes that share expression patterns with TMPRSS9: view

Protein tissue co-expression partners for TMPRSS9 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for TMPRSS9 Gene

Orthologs for TMPRSS9 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMPRSS9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMPRSS9 36
  • 98 (a)
OneToOne
TMPRSS9 35
  • 98.65 (n)
  • 98.39 (a)
cow
(Bos Taurus)
Mammalia TMPRSS9 35
  • 84.32 (n)
  • 83 (a)
TMPRSS9 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMPRSS9 36
  • 73 (a)
OneToOne
TMPRSS9 35
  • 80.91 (n)
  • 77.62 (a)
mouse
(Mus musculus)
Mammalia Tmprss9 16
Tmprss9 36
  • 77 (a)
OneToOne
Tmprss9 35
  • 78.99 (n)
  • 79.87 (a)
oppossum
(Monodelphis domestica)
Mammalia TMPRSS9 36
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMPRSS9 36
  • 59 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmprss9 35
  • 78.45 (n)
  • 79.05 (a)
chicken
(Gallus gallus)
Aves TMPRSS9 35
  • 67.03 (n)
  • 64.53 (a)
TMPRSS9 36
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmprss9 35
  • 60.14 (n)
  • 60.52 (a)
zebrafish
(Danio rerio)
Actinopterygii tmprss9 36
  • 39 (a)
OneToOne
tmprss9 35
  • 50.98 (n)
  • 42.92 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006869 35
  • 48.01 (n)
  • 44.02 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG13744 36
  • 26 (a)
OneToMany
CG8170 36
  • 15 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea try-1 36
  • 32 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 33 (a)
OneToOne
Species with no ortholog for TMPRSS9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMPRSS9 Gene

ENSEMBL:
Gene Tree for TMPRSS9 (if available)
TreeFam:
Gene Tree for TMPRSS9 (if available)

Paralogs for TMPRSS9 Gene

Paralogs for TMPRSS9 Gene

genes like me logo Genes that share paralogs with TMPRSS9: view

Variants for TMPRSS9 Gene

Sequence variations from dbSNP and Humsavar for TMPRSS9 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs891174 - 2,389,874(+) GGCCA(C/G)CATTG reference, missense
rs735911 - 2,422,179(+) CGTGA(A/C/G)CACCA reference, missense
VAR_021510 -
rs17685098 - 2,396,613(+) GTTTG(C/T)GGCGG reference, missense
rs8100709 - 2,389,795(+) AGCCC(A/G)CTGTG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for TMPRSS9 Gene

Variant ID Type Subtype PubMed ID
nsv910623 CNV Loss 21882294
nsv910650 CNV Gain 21882294
esv272241 CNV Insertion 20981092
esv1399285 CNV Deletion 17803354
dgv3636n71 CNV Loss 21882294
dgv3637n71 CNV Loss 21882294
esv1707583 CNV Deletion 17803354
nsv910655 CNV Loss 21882294
dgv3638n71 CNV Loss 21882294
nsv910660 CNV Loss 21882294
dgv3639n71 CNV Loss 21882294
esv2677064 CNV Deletion 23128226
nsv910665 CNV Loss 21882294
esv2664636 CNV Deletion 23128226
nsv910667 CNV Loss 21882294

Variation tolerance for TMPRSS9 Gene

Residual Variation Intolerance Score: 98.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 16.19; 97.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMPRSS9 Gene

HapMap Linkage Disequilibrium report
TMPRSS9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMPRSS9 Gene

Disorders for TMPRSS9 Gene

Relevant External Links for TMPRSS9

Genetic Association Database (GAD)
TMPRSS9
Human Genome Epidemiology (HuGE) Navigator
TMPRSS9
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMPRSS9

No disorders were found for TMPRSS9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMPRSS9 Gene

Publications for TMPRSS9 Gene

  1. Polyserase-I, a human polyprotease with the ability to generate independent serine protease domains from a single translation product. (PMID: 12886014) Cal S. … Lopez-Otin C. (Proc. Natl. Acad. Sci. U.S.A. 2003) 2 3 4 23 67
  2. Serase-1B, a new splice variant of polyserase-1/TMPRSS9, activates urokinase-type plasminogen activator and the proteolytic activation is negatively regulated by glycosaminoglycans. (PMID: 16872279) Okumura Y. … Kido H. (Biochem. J. 2006) 3 23
  3. Polyserase-1/TMPRSS9 induces pro-tumor effects in pancreatic cancer cells by activation of pro-uPA. (PMID: 24756697) Fontanil T. … Cal S. (Oncol. Rep. 2014) 3
  4. TMPRSS9 and GRIN2B are associated with neuroticism: a genome-wide association study in a European sample. (PMID: 23229837) Aragam N. … Liu X. (J. Mol. Neurosci. 2013) 3
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3

Products for TMPRSS9 Gene

Sources for TMPRSS9 Gene

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