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Aliases for TMPRSS9 Gene

Aliases for TMPRSS9 Gene

  • Transmembrane Protease, Serine 9 2 3
  • Polyserine Protease 1 3 4
  • Polyserase 1 2 3
  • Polyserase-1 3 4
  • Polyserase-I 3 4
  • Transmembrane Protease Serine 9 3
  • Transmembrane Serine Protease 9 3
  • EC 64
  • EC 3.4.21.- 4
  • EC 3.4.21 64

External Ids for TMPRSS9 Gene

Summaries for TMPRSS9 Gene

GeneCards Summary for TMPRSS9 Gene

TMPRSS9 is a Protein Coding gene. GO annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is TPSAB1.

UniProtKB/Swiss-Prot for TMPRSS9 Gene

  • Serase-1 and serase-2 are serine proteases that hydrolyze the peptides N-t-Boc-Gln-Ala-Arg-AMC and N-t-Boc-Gln-Gly-Arg-AMC. In contrast, N-t-Boc-Ala-Phe-Lys-AMC and N-t-Boc-Ala-Pro-Ala-AMC are not significantly hydrolyzed

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMPRSS9 Gene

Genomics for TMPRSS9 Gene

Genomic Location for TMPRSS9 Gene

2,381,507 bp from pter
2,426,482 bp from pter
44,976 bases
Plus strand

Genomic View for TMPRSS9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMPRSS9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMPRSS9 Gene

Regulatory Elements for TMPRSS9 Gene

Transcription factor binding sites by QIAGEN in the TMPRSS9 gene promoter:

Proteins for TMPRSS9 Gene

  • Protein details for TMPRSS9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protease serine 9
    Protein Accession:
    Secondary Accessions:
    • Q6ZND6
    • Q7Z411

    Protein attributes for TMPRSS9 Gene

    1059 amino acids
    Molecular mass:
    114021 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAD18439.1; Type=Frameshift; Positions=776; Evidence={ECO:0000305}; Sequence=CAD35759.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305};

neXtProt entry for TMPRSS9 Gene

Proteomics data for TMPRSS9 Gene at MOPED

Selected DME Specific Peptides for TMPRSS9 Gene

Post-translational modifications for TMPRSS9 Gene

  • Proteolytically cleaved to generate 3 independent serine protease chains. The cleaved chains may remain attached to the membrane thanks to disufide bonds. It is unclear whether cleavage always takes place.
  • Glycosylation at Asn547, Asn638, Asn663, and Asn786

Other Protein References for TMPRSS9 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for TMPRSS9 Gene

Gene Families for TMPRSS9 Gene

  • TMPRSS :Serine peptidases / Transmembrane


  • The serine protease 1 and 2 domains are catalytically active, whereas the serine protease 3 domain lacks the essential Ser residue of the catalytic triad at position 1009 and is predicted to be inactive:
    • Q7Z410
  • Contains 1 LDL-receptor class A domain.:
    • Q7Z410
  • Contains 3 peptidase S1 domains.:
    • Q7Z410
  • Belongs to the peptidase S1 family.:
    • Q7Z410
genes like me logo Genes that share domains with TMPRSS9: view

Function for TMPRSS9 Gene

Molecular function for TMPRSS9 Gene

UniProtKB/Swiss-Prot EnzymeRegulation: Inhibited by serine protease inhibitors PMSF and 4-(2-aminoethyl)benzenesulfonyl fluoride, but not by EDTA.
UniProtKB/Swiss-Prot Function: Serase-1 and serase-2 are serine proteases that hydrolyze the peptides N-t-Boc-Gln-Ala-Arg-AMC and N-t-Boc-Gln-Gly-Arg-AMC. In contrast, N-t-Boc-Ala-Phe-Lys-AMC and N-t-Boc-Ala-Pro-Ala-AMC are not significantly hydrolyzed

Enzyme Numbers (IUBMB) for TMPRSS9 Gene

Gene Ontology (GO) - Molecular Function for TMPRSS9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004252 serine-type endopeptidase activity IEA --
GO:0005515 protein binding --
GO:0008236 serine-type peptidase activity --
genes like me logo Genes that share ontologies with TMPRSS9: view

Phenotypes for TMPRSS9 Gene

GenomeRNAi human phenotypes for TMPRSS9:
genes like me logo Genes that share phenotypes with TMPRSS9: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TMPRSS9 Gene

Localization for TMPRSS9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMPRSS9 Gene

Cell membrane; Single-pass type II membrane protein.

Subcellular locations from

Jensen Localization Image for TMPRSS9 Gene COMPARTMENTS Subcellular localization image for TMPRSS9 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 1
extracellular 1
lysosome 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TMPRSS9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IEA --
genes like me logo Genes that share ontologies with TMPRSS9: view

Pathways for TMPRSS9 Gene

SuperPathways for TMPRSS9 Gene

No Data Available

Interacting Proteins for TMPRSS9 Gene

Gene Ontology (GO) - Biological Process for TMPRSS9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis --
GO:0031639 plasminogen activation IEA --
genes like me logo Genes that share ontologies with TMPRSS9: view

No data available for Pathways by source for TMPRSS9 Gene

Compounds for TMPRSS9 Gene

(1) Novoseek inferred chemical compound relationships for TMPRSS9 Gene

Compound -log(P) Hits PubMed IDs
serine 55.7 8
genes like me logo Genes that share compounds with TMPRSS9: view

Transcripts for TMPRSS9 Gene

mRNA/cDNA for TMPRSS9 Gene

Unigene Clusters for TMPRSS9 Gene

Transmembrane protease, serine 9:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMPRSS9 Gene

No ASD Table

Relevant External Links for TMPRSS9 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMPRSS9 Gene

mRNA expression in normal human tissues for TMPRSS9 Gene

mRNA differential expression in normal tissues according to GTEx for TMPRSS9 Gene

This gene is overexpressed in Testis (8.1), Liver (7.7), and Spleen (4.2).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for TMPRSS9 Gene

SOURCE GeneReport for Unigene cluster for TMPRSS9 Gene Hs.465560

mRNA Expression by UniProt/SwissProt for TMPRSS9 Gene

Tissue specificity: Expressed in fetal human tissues, such as kidney, liver, lung and brain, and in a variety of tumor cell lines. Weakly expressed in adult tissues including skeletal muscle, liver, placenta and heart.
genes like me logo Genes that share expressions with TMPRSS9: view

Orthologs for TMPRSS9 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMPRSS9 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMPRSS9 36
  • 98.65 (n)
  • 98.39 (a)
  • 98 (a)
(Bos Taurus)
Mammalia TMPRSS9 36
  • 84.32 (n)
  • 83 (a)
  • 80 (a)
(Canis familiaris)
Mammalia TMPRSS9 36
  • 80.91 (n)
  • 77.62 (a)
  • 73 (a)
(Mus musculus)
Mammalia Tmprss9 36
  • 78.99 (n)
  • 79.87 (a)
Tmprss9 16
Tmprss9 37
  • 77 (a)
(Monodelphis domestica)
Mammalia TMPRSS9 37
  • 64 (a)
(Ornithorhynchus anatinus)
Mammalia TMPRSS9 37
  • 59 (a)
(Rattus norvegicus)
Mammalia Tmprss9 36
  • 78.45 (n)
  • 79.05 (a)
(Gallus gallus)
Aves TMPRSS9 36
  • 67.03 (n)
  • 64.53 (a)
  • 59 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tmprss9 36
  • 60.14 (n)
  • 60.52 (a)
(Danio rerio)
Actinopterygii tmprss9 36
  • 50.98 (n)
  • 42.92 (a)
tmprss9 37
  • 39 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006869 36
  • 48.01 (n)
  • 44.02 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG13744 37
  • 26 (a)
CG8170 37
  • 15 (a)
(Caenorhabditis elegans)
Secernentea try-1 37
  • 32 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 33 (a)
Species with no ortholog for TMPRSS9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMPRSS9 Gene

Gene Tree for TMPRSS9 (if available)
Gene Tree for TMPRSS9 (if available)

Paralogs for TMPRSS9 Gene

genes like me logo Genes that share paralogs with TMPRSS9: view

Variants for TMPRSS9 Gene

Sequence variations from dbSNP and Humsavar for TMPRSS9 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs735911 - 2,422,179(+) CGTGA(A/G)CACCA missense, reference
rs891173 -- 2,389,625(+) AGCCT(C/T)CCAAA upstream-variant-2KB, intron-variant
rs891174 - 2,389,874(+) GGCCA(C/G)CATTG missense, reference
rs891175 -- 2,389,956(+) GGTTC(A/G)CAATA intron-variant
rs891176 -- 2,389,960(+) CGCAA(A/T)ACAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMPRSS9 Gene

Variant ID Type Subtype PubMed ID
nsv910623 CNV Loss 21882294
nsv910650 CNV Gain 21882294
esv272241 CNV Insertion 20981092
esv1399285 CNV Deletion 17803354
dgv3636n71 CNV Loss 21882294
dgv3637n71 CNV Loss 21882294
esv1707583 CNV Deletion 17803354
nsv910655 CNV Loss 21882294
dgv3638n71 CNV Loss 21882294
nsv910660 CNV Loss 21882294
dgv3639n71 CNV Loss 21882294
esv2677064 CNV Deletion 23128226
nsv910665 CNV Loss 21882294
esv2664636 CNV Deletion 23128226
nsv910667 CNV Loss 21882294

Relevant External Links for TMPRSS9 Gene

HapMap Linkage Disequilibrium report

Disorders for TMPRSS9 Gene

Relevant External Links for TMPRSS9

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with TMPRSS9: view

No data available for UniProtKB/Swiss-Prot for TMPRSS9 Gene

Publications for TMPRSS9 Gene

  1. Polyserase-I, a human polyprotease with the ability to generate independent serine protease domains from a single translation product. (PMID: 12886014) Cal S. … Lopez-Otin C. (Proc. Natl. Acad. Sci. U.S.A. 2003) 2 3 4 23
  2. Serase-1B, a new splice variant of polyserase-1/TMPRSS9, activates urokinase-type plasminogen activator and the proteolytic activation is negatively regulated by glycosaminoglycans. (PMID: 16872279) Okumura Y. … Kido H. (Biochem. J. 2006) 3 23
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49
  5. TMPRSS9 and GRIN2B are associated with neuroticism: a genome-wide association study in a European sample. (PMID: 23229837) Aragam N. … Liu X. (J. Mol. Neurosci. 2013) 3

Products for TMPRSS9 Gene

Sources for TMPRSS9 Gene

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