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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TMPRSS7 Gene

protein-coding   GIFtS: 38
GCID: GC03P111753

Transmembrane Protease, Serine 7

(Previous name: type II transmembrane serine protease 7)
  Search for TMPRSS7
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Transmembrane Protease, Serine 71 2     EC 3.4.21.-3
Type II Transmembrane Serine Protease 71 2     Matriptase-33
matriptase-32     EC 3.4.218
Transmembrane Protease Serine 72     EC 3.4.21.1098
Transmembrane Serine Protease 72     EC 3.4.21.98

External Ids:    HGNC: 308461   Entrez Gene: 3448052   Ensembl: ENSG000001760407   UniProtKB: Q7RTY83   
ORGUL members:         
NONCODE14:n407265      

Export aliases for TMPRSS7 gene to outside databases

Previous GC identifers: GC03P113034 GC03P113082 GC03P113241 GC03P109133


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TMPRSS7 Gene: 
TMPRSS7 (transmembrane protease, serine 7) is a protein-coding gene, and is affiliated with the lncRNA class. GO annotations related to this gene include serine-type peptidase activity and serine-type endopeptidase activity. An important paralog of this gene is TMPRSS11D.

UniProtKB/Swiss-Prot: TMPS7_HUMAN, Q7RTY8
Function: Serine protease which preferentially hydrolyzes peptides with Arg at the P1 position (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_005612.16  NC_018914.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TMPRSS7 gene promoter:
         Sox5   Nkx2-5   Tal-1beta   YY1   HNF-1A   E47   FOXL1   PPAR-gamma1   HNF-1   PPAR-gamma2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for TMPRSS7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMPRSS7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q13.2   Ensembl cytogenetic band:  3q13.2   HGNC cytogenetic band: 3q13.2

TMPRSS7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMPRSS7 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P111753:  view genomic region     (about GC identifiers)

Start:
111,753,690 bp from pter      End:
111,800,116 bp from pter
Size:
46,427 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TMPS7_HUMAN, Q7RTY8 (See protein sequence)
Recommended Name: Transmembrane protease serine 7  
Size: 843 amino acids; 94415 Da
Subunit: Forms a heterodimer with SERPINA5
Subcellular location: Cell membrane; Single-pass type II membrane protein (By similarity)
Secondary accessions: C9J8P7 E9PAS3 Q17RH4
Alternative splicing: 3 isoforms:  Q7RTY8-1   Q7RTY8-2   Q7RTY8-3   (Gene prediction based on similarity to mouse ortholog)

Explore the universe of human proteins at neXtProt for TMPRSS7: NX_Q7RTY8

Explore proteomics data for TMPRSS7 at MOPED 

Post-translational modifications:

  • UniProtKB: N-glycosylated (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q7RTY8

  • 4/7 DME Specific Peptides for TMPRSS7 (Q7RTY8) (see all 7)
     TGIVSWG  GDSGGPL  WPWQVSL  CWVTGWG 

    TMPRSS7 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TMPRSS7 Protein Expression
    REFSEQ proteins: NP_001036040.2  
    ENSEMBL proteins: 
     ENSP00000398236   ENSP00000415472   ENSP00000411645   ENSP00000447563  

    Human Recombinant Protein Products for TMPRSS7: 
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TMPRSS7 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane ISS--
    GO:0016021integral to membrane IEA--

    TMPRSS7 for ontologies           About GeneDecksing



    TMPRSS7 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    TMPRSS: Serine peptidases / Transmembrane

    5/8 InterPro protein domains (see all 8):
     IPR000859 CUB_dom
     IPR002172 LDrepeatLR_classA_rpt
     IPR001314 Peptidase_S1A
     IPR023415 LDLR_class-A_CS
     IPR000082 SEA_dom

    Graphical View of Domain Structure for InterPro Entry Q7RTY8

    ProtoNet protein and cluster: Q7RTY8

    4 Blocks protein domains:
    IPB000859 CUB domain
    IPB001254 Serine protease
    IPB001314 Chymotrypsin serine protease family (S1) signature
    IPB002172 Low density lipoprotein-receptor


    UniProtKB/Swiss-Prot: TMPS7_HUMAN, Q7RTY8
    Similarity: Belongs to the peptidase S1 family
    Similarity: Contains 2 CUB domains
    Similarity: Contains 3 LDL-receptor class A domains
    Similarity: Contains 1 peptidase S1 domain
    Similarity: Contains 1 SEA domain


    TMPRSS7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TMPS7_HUMAN, Q7RTY8
    Function: Serine protease which preferentially hydrolyzes peptides with Arg at the P1 position (By similarity)

         Enzyme Numbers (IUBMB): EC 3.4.212 EC 3.4.21.92 EC 3.4.21.1092 EC 3.4.21.-1

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004252serine-type endopeptidase activity IEA--
    GO:0005515protein binding ----
    GO:0008236serine-type peptidase activity ISS--
         
    TMPRSS7 for ontologies           About GeneDecksing


    Animal Models:
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    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMPRSS7


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMPRSS7

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis ISS--

    TMPRSS7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TMPRSS7 (TMPS7)

    Search CenterWatch for drugs/clinical trials and news about TMPRSS7 / TMPS7

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TMPRSS7 gene: 
    NM_001042575.2  

    Unigene Cluster for TMPRSS7:

    Transmembrane protease, serine 7
    Hs.435490  [show with all ESTs]
    Unigene Representative Sequence: AK131211
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000452346 ENST00000435737(uc011bhr.1 uc010hqb.2) ENST00000419127
    ENST00000460599
    miRNA
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    5 QIAGEN miScript miRNA Assays for microRNAs that regulate TMPRSS7:
    hsa-miR-27a hsa-miR-128 hsa-miR-3681* hsa-miR-551b* hsa-miR-27b
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TMPRSS7
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    Clone
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    OriGene ORF clones in mouse, rat for TMPRSS7
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMPRSS7
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMPRSS7

    Additional mRNA sequence: 

    AK131211.1 BC117322.1 NR_026734.1 

    2 DOTS entries:

    DT.102820283  DT.99972619 

    5 AceView cDNA sequences:

    BN000125 AK131211 BI559602 AA913691 AA649629 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TMPRSS7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    TMPRSS7 Expression
    About this image


    See TMPRSS7 Protein Expression from SPIRE MOPED and PaxDB
    SOURCE GeneReport for Unigene cluster: Hs.435490

    UniProtKB/Swiss-Prot: TMPS7_HUMAN, Q7RTY8
    Tissue specificity: Expressed in brain, ovary, testis, salivary gland, trachea and lung

        SABiosciences Custom PCR Arrays for TMPRSS7
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMPRSS7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TMPRSS7 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tmprss71 , 5 transmembrane serine protease 71, 5 87.03(n)1
    90.93(a)1
      16 (29.84 cM)5
    2081711  NM_172455.31  NP_766043.31 
     456563155 
    chicken
    (Gallus gallus)
    Aves TMPRSS71 transmembrane protease, serine 7 71.08(n)
    67.92(a)
      769974  XM_001233290.2  XP_001233291.1 
    lizard
    (Anolis carolinensis)
    Reptilia TMPRSS76
    Uncharacterized protein
    60(a)
    1 ↔ 1
    3(167654581-167678919)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC7984801 transmembrane protease serine 7-like 56.1(n)
    50.42(a)
      798480  XM_002666653.2  XP_002666699.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta Corin6
    CG16326
    --
    11(a)
    10(a)
    possible ortholog
    possible ortholog
    2R(3433167-3448759)
    X(8146705-8166495)


    ENSEMBL Gene Tree for TMPRSS7 (if available)
    TreeFam Gene Tree for TMPRSS7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TMPRSS7 gene
    TMPRSS11D2  TMPRSS32  TMPRSS11B2  TMPRSS62  TMPRSS11A2  TMPRSS52  TMPRSS42  ST142  
    TMPRSS132  TMPRSS11E2  KLKB12  TMPRSS22  F112  HPN2  TMPRSS152  TMPRSS11F2  
    18/53 SIMAP similar genes for TMPRSS7 using alignment to 4 protein entries:     TMPS7_HUMAN (see all proteins) (see all similar genes):
    PRSS1    F12    HP    PROC1    TMPRSS11D    PROC
    CELA2A    TMPRSS11E    CTRB1    CTRB2    PRSS45    F9
    DKFZp586F0824    PRSS2    TRY8    TMPRSS6    CELA2B    CTRC

    TMPRSS7 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1174 SNPs in TMPRSS7 are shown (see all 1174)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs98622891,2
    C,F--111756471(+) cactaC/Tctccc 2 -- us2k12Minor allele frequency- T:0.19NA EA 240
    rs1383174731,2
    C--111756487(+) AAAATC/TGCTAA 2 -- us2k10--------
    rs1894912771,2
    --111756510(+) GGTTTC/TGTGGC 2 -- us2k10--------
    rs1492284321,2
    --111756552(+) GATGTC/TTTCCC 2 -- us2k10--------
    rs1432336891,2
    --111756635(+) GAAAAC/TAGAAA 2 -- us2k10--------
    rs1390878311,2
    --111756702(+) GGTTTA/GTATAC 2 -- us2k10--------
    rs1408855451,2
    C--111756816(+) AATAG-/TCATAT 2 -- us2k10--------
    rs1820579711,2
    --111756838(+) AGTACA/CAACAT 2 -- us2k10--------
    rs1126146951,2
    C,F--111756921(+) AAGATA/GTCCAA 2 -- us2k12Minor allele frequency- G:0.09CSA WA 119
    rs43215071,2
    C,F--111756977(+) ACGACC/TACCGT 2 -- us2k11Minor allele frequency- T:0.05NA 120

    HapMap Linkage Disequilibrium report for TMPRSS7 (111753690 - 111800116 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TMPRSS7: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing TMPRSS7
    DNA2.0 Custom Variant and Variant Library Synthesis for TMPRSS7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TMPRSS7 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with TMPRSS7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human and mouse proteases: a comparative genomic approach. (PubMed id 12838346)1, 2, 3 Puente X.S.... Lopez-Otin C. (2003)
    2. The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)1, 2 Muzny D.M....Gibbs R.A. (2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Matriptase-3 is a novel phylogenetically preserved membrane-anchored serine protease with broad serpin reactivity. (PubMed id 15853774)2 Szabo R....Bugge T.H. (2005)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 344805 HGNC: 30846 AceView: TMPRSS7 Ensembl:ENSG00000176040 euGenes: HUgn344805
    ECgene: TMPRSS7 H-InvDB: TMPRSS7

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TMPRSS7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TMPRSS7 gene:
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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