Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TMPRSS7 Gene

Aliases for TMPRSS7 Gene

  • Transmembrane Protease, Serine 7 2 3 5
  • Type II Transmembrane Serine Protease 7 2 3
  • Matriptase-3 3 4
  • Transmembrane Serine Protease 7 3
  • EC 63
  • EC 63
  • EC 3.4.21.- 4
  • EC 3.4.21 63

External Ids for TMPRSS7 Gene

Previous GeneCards Identifiers for TMPRSS7 Gene

  • GC03P113034
  • GC03P113082
  • GC03P113241
  • GC03P111753
  • GC03P109133

Summaries for TMPRSS7 Gene

GeneCards Summary for TMPRSS7 Gene

TMPRSS7 (Transmembrane Protease, Serine 7) is a Protein Coding gene. GO annotations related to this gene include serine-type endopeptidase activity and serine-type peptidase activity. An important paralog of this gene is ST14.

UniProtKB/Swiss-Prot for TMPRSS7 Gene

  • Serine protease which preferentially hydrolyzes peptides with Arg at the P1 position.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMPRSS7 Gene

Genomics for TMPRSS7 Gene

Regulatory Elements for TMPRSS7 Gene

Enhancers for TMPRSS7 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TMPRSS7 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMPRSS7 Gene

112,034,843 bp from pter
112,081,269 bp from pter
46,427 bases
Plus strand

Genomic View for TMPRSS7 Gene

Genes around TMPRSS7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMPRSS7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMPRSS7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMPRSS7 Gene

Proteins for TMPRSS7 Gene

  • Protein details for TMPRSS7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protease serine 7
    Protein Accession:
    Secondary Accessions:
    • C9J8P7
    • E9PAS3
    • Q17RH4

    Protein attributes for TMPRSS7 Gene

    843 amino acids
    Molecular mass:
    94415 Da
    Quaternary structure:
    • Forms a heterodimer with SERPINA5.

    Alternative splice isoforms for TMPRSS7 Gene


neXtProt entry for TMPRSS7 Gene

Proteomics data for TMPRSS7 Gene at MOPED

Selected DME Specific Peptides for TMPRSS7 Gene

Post-translational modifications for TMPRSS7 Gene

Other Protein References for TMPRSS7 Gene

Domains & Families for TMPRSS7 Gene

Gene Families for TMPRSS7 Gene

Suggested Antigen Peptide Sequences for TMPRSS7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 CUB domains.
  • Belongs to the peptidase S1 family.
  • Contains 2 CUB domains.
  • Contains 3 LDL-receptor class A domains.
  • Contains 1 peptidase S1 domain.
  • Contains 1 SEA domain.
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with TMPRSS7: view

Function for TMPRSS7 Gene

Molecular function for TMPRSS7 Gene

UniProtKB/Swiss-Prot Function:
Serine protease which preferentially hydrolyzes peptides with Arg at the P1 position.

Enzyme Numbers (IUBMB) for TMPRSS7 Gene

genes like me logo Genes that share phenotypes with TMPRSS7: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TMPRSS7

CRISPR Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMPRSS7 Gene

Localization for TMPRSS7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMPRSS7 Gene

Cell membrane; Single-pass type II membrane protein.

Subcellular locations from

Jensen Localization Image for TMPRSS7 Gene COMPARTMENTS Subcellular localization image for TMPRSS7 gene
Compartment Confidence
plasma membrane 4
cytosol 2
nucleus 2

No data available for Gene Ontology (GO) - Cellular Components for TMPRSS7 Gene

Pathways & Interactions for TMPRSS7 Gene

SuperPathways for TMPRSS7 Gene

No Data Available

Interacting Proteins for TMPRSS7 Gene

Gene Ontology (GO) - Biological Process for TMPRSS7 Gene


No data available for Pathways by source and SIGNOR curated interactions for TMPRSS7 Gene

Drugs & Compounds for TMPRSS7 Gene

No Compound Related Data Available

Transcripts for TMPRSS7 Gene

mRNA/cDNA for TMPRSS7 Gene

(8) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMPRSS7 Gene

Transmembrane protease, serine 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMPRSS7 Gene

No ASD Table

Relevant External Links for TMPRSS7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMPRSS7 Gene

mRNA expression in normal human tissues for TMPRSS7 Gene

mRNA differential expression in normal tissues according to GTEx for TMPRSS7 Gene

This gene is overexpressed in Testis (x19.4) and Pituitary (x4.2).

Protein differential expression in normal tissues from HIPED for TMPRSS7 Gene

This gene is overexpressed in Pancreatic juice (68.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMPRSS7 Gene

SOURCE GeneReport for Unigene cluster for TMPRSS7 Gene Hs.435490

mRNA Expression by UniProt/SwissProt for TMPRSS7 Gene

Tissue specificity: Expressed in brain, ovary, testis, salivary gland, trachea and lung.
genes like me logo Genes that share expression patterns with TMPRSS7: view

Protein tissue co-expression partners for TMPRSS7 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for TMPRSS7 Gene

Orthologs for TMPRSS7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMPRSS7 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TMPRSS7 35
  • 90.66 (n)
  • 91.21 (a)
  • 79 (a)
(Canis familiaris)
Mammalia TMPRSS7 35
  • 90.14 (n)
  • 92.33 (a)
  • 81 (a)
(Mus musculus)
Mammalia Tmprss7 35
  • 87.03 (n)
  • 90.93 (a)
Tmprss7 16
Tmprss7 36
  • 79 (a)
(Pan troglodytes)
Mammalia TMPRSS7 35
  • 99.54 (n)
  • 99.44 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Tmprss7 35
  • 87.73 (n)
  • 90.66 (a)
(Monodelphis domestica)
Mammalia TMPRSS7 36
  • 72 (a)
(Ornithorhynchus anatinus)
Mammalia TMPRSS7 36
  • 72 (a)
(Gallus gallus)
Aves TMPRSS7 35
  • 71.18 (n)
  • 68.2 (a)
  • 59 (a)
(Anolis carolinensis)
Reptilia TMPRSS7 36
  • 60 (a)
(Danio rerio)
Actinopterygii LOC798480 35
  • 56.1 (n)
  • 50.42 (a)
  • 46 (a)
Species with no ortholog for TMPRSS7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMPRSS7 Gene

Gene Tree for TMPRSS7 (if available)
Gene Tree for TMPRSS7 (if available)

Paralogs for TMPRSS7 Gene

Paralogs for TMPRSS7 Gene

genes like me logo Genes that share paralogs with TMPRSS7: view

Variants for TMPRSS7 Gene

Sequence variations from dbSNP and Humsavar for TMPRSS7 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs340142 -- 112,061,824(+) TTTTT(C/T)GAGTG nc-transcript-variant, reference, stop-gained
rs340143 -- 112,062,747(+) CCAGC(A/T)TCTCA intron-variant
rs340144 -- 112,063,798(+) CATGC(A/C/T)TCTGT intron-variant
rs340145 -- 112,064,278(+) TCAGC(A/G)TGCTC intron-variant
rs340146 -- 112,066,042(+) CACTC(C/T)TATTT intron-variant

Variation tolerance for TMPRSS7 Gene

Residual Variation Intolerance Score: 95.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.36; 90.79% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for TMPRSS7 Gene

Disorders for TMPRSS7 Gene

Relevant External Links for TMPRSS7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TMPRSS7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMPRSS7 Gene

Publications for TMPRSS7 Gene

  1. Human and mouse proteases: a comparative genomic approach. (PMID: 12838346) Puente X.S. … Lopez-Otin C. (Nat. Rev. Genet. 2003) 2 3 4 67
  2. Type II transmembrane serine protease gene variants associate with breast cancer. (PMID: 25029565) Luostari K. … Kosma V.M. (PLoS ONE 2014) 3
  3. Genome wide association and linkage analyses identified three loci-4q25, 17q23.2, and 10q11.21-associated with variation in leukocyte telomere length: the Long Life Family Study. (PMID: 24478790) Lee J.H. … Mayeux R. (Front Genet 2013) 3
  4. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny D.M. … Gibbs R.A. (Nature 2006) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for TMPRSS7 Gene

Sources for TMPRSS7 Gene