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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TMPRSS7 Gene

protein-coding   GIFtS: 37
GCID: GC03P111753

transmembrane protease, serine 7

(Previous name: type II transmembrane serine protease 7 )
  Search for TMPRSS7
in
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 Human Malady Compendium 
Biological research products
for TMPRSS7    

Aliases
for TMPRSS7 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Transmembrane Protease, Serine 71 2     EC 3.4.21.-3
Type II Transmembrane Serine Protease 71 2     Matriptase-33
Matriptase-33     EC 3.4.218
Transmembrane Protease Serine 72     EC 3.4.21.1098
Transmembrane Serine Protease 72     EC 3.4.21.98

External Ids:    HGNC: 308461   Entrez Gene: 3448052   Ensembl: ENSG000001760407   UniProtKB: Q7RTY83   
ORGUL members:         
NONCODE:n407265    

Export aliases for TMPRSS7 gene to outside databases

Previous GC identifers: GC03P113034 GC03P113082 GC03P113241 GC03P109133


Summaries
for TMPRSS7 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: TMPS7_HUMAN, Q7RTY8
Function: Serine protease which preferentially hydrolyzes peptides with Arg at the P1 position (By similarity)




Genomic Views
for TMPRSS7 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_005612.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TMPRSS7 gene promoter:
         Sox5   Nkx2-5   Tal-1beta   YY1   HNF-1A   E47   FOXL1   PPAR-gamma1   HNF-1   PPAR-gamma2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for TMPRSS7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMPRSS7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q13.2   Ensembl cytogenetic band:  3q13.2   HGNC cytogenetic band: 3q13.2

TMPRSS7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMPRSS7 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P111753:  view genomic region     (about GC identifiers)

Start:
 111,753,690 bp from pter      End:
 111,800,116 bp from pter
Size:
 46,427 bases      Orientation:
 plus strand

Proteins
for TMPRSS7 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: TMPS7_HUMAN, Q7RTY8 (See protein sequence)
Recommended Name: Transmembrane protease serine 7  
Size: 843 amino acids; 94415 Da
Subunit: Forms a heterodimer with SERPINA5
Subcellular location: Cell membrane; Single-pass type II membrane protein (By similarity)
Secondary accessions: C9J8P7 E9PAS3 Q17RH4
Alternative splicing: 3 isoforms:  Q7RTY8-1   Q7RTY8-2   Q7RTY8-3   (Gene prediction based on similarity to mouse ortholog)

Explore the universe of human proteins at neXtProt for TMPRSS7: NX_Q7RTY8

Post-translational modifications:

  • N-glycosylated (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q7RTY8

    • 4/7 DME Specific Peptides for TMPRSS7 (Q7RTY8) (see all 7)
     TGIVSWG  GDSGGPL  WPWQVSL  CWVTGWG 

    TMPRSS7 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001036040.2  
    ENSEMBL proteins: 
     ENSP00000398236   ENSP00000415472   ENSP00000411645   ENSP00000447563  

    Human Recombinant Protein Products: 
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    Novus Biologicals TMPRSS7 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for TMPRSS7

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane ISS--
    GO:0016021integral to membrane IEA--


    TMPRSS7 for ontologies           About GeneDecksing



    TMPRSS7 Antibody Products: 
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    Uscn ELISAs and CLIAs for TMPRSS7

    Protein Domains /
    Families
    for TMPRSS7 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    TMPRSS7 for domains           About GeneDecksing

    5/8 InterPro domains/families (see all 8):
     IPR000859 CUB_dom
     IPR002172 LDrepeatLR_classA_rpt
     IPR001314 Peptidase_S1A
     IPR023415 LDLR_class-A_CS
     IPR000082 SEA

    Graphical View of Domain Structure for InterPro Entry Q7RTY8

    ProtoNet protein and cluster: Q7RTY8

    4 Blocks protein families:
    IPB000859 CUB domain
    IPB001254 Serine protease
    IPB001314 Chymotrypsin serine protease family (S1) signature
    IPB002172 Low density lipoprotein-receptor


    UniProtKB/Swiss-Prot: TMPS7_HUMAN, Q7RTY8
    Similarity: Belongs to the peptidase S1 family
    Similarity: Contains 2 CUB domains
    Similarity: Contains 3 LDL-receptor class A domains
    Similarity: Contains 1 peptidase S1 domain
    Similarity: Contains 1 SEA domain


    Function
    for TMPRSS7 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: TMPS7_HUMAN, Q7RTY8
    Function: Serine protease which preferentially hydrolyzes peptides with Arg at the P1 position (By similarity)

    Enzyme Numbers (IUBMB): EC 3.4.212 EC 3.4.21.92 EC 3.4.21.1092 EC 3.4.21.-1

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TMPRSS7
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate TMPRSS7:
    hsa-miR-27a hsa-miR-128 hsa-miR-3681* hsa-miR-551b* hsa-miR-27b
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    Inhib. RNA
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    OriGene shRNA RFP: TMPRSS7
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    Gene Editing
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    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMPRSS7 (see all 4)
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    In Situ Assay
    Products:       
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004252serine-type endopeptidase activity IEA--
    GO:0005515protein binding ----
    GO:0008236serine-type peptidase activity ISS--


    TMPRSS7 for ontologies           About GeneDecksing



    Pathways & Interactions
    for TMPRSS7 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMPRSS7

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis ISS--


    TMPRSS7 for ontologies           About GeneDecksing



    Drugs & Compounds
    for TMPRSS7 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TMPRSS7
    Search CenterWatch for drugs/clinical trials and news about TMPRSS7 / TMPS7 

    Transcripts
    for TMPRSS7 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for TMPRSS7 gene: 
    NM_001042575.2  

    Unigene Cluster for TMPRSS7:

    Transmembrane protease, serine 7
    Hs.435490  [show with all ESTs]
    Unigene Representative Sequence: AK131211
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000452346 ENST00000435737(uc011bhr.1 uc010hqb.2) ENST00000419127
    ENST00000460599

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TMPRSS7
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate TMPRSS7:
    hsa-miR-27a hsa-miR-128 hsa-miR-3681* hsa-miR-551b* hsa-miR-27b
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMPRSS7 (see all 7)
    OriGene shRNA RFP: TMPRSS7
    OriGene siRNA: TMPRSS7
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMPRSS7
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMPRSS7 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMPRSS7 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: TMPRSS7 (NM_001042575)
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    Primer
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    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat TMPRSS7
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMPRSS7
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMPRSS7

    Additional cDNA sequence: 

    AK131211.1 BC117322.1 NR_026734.1 

    2 DOTS entries:

    DT.102820283  DT.99972619 

    5 AceView cDNA sequences:

    BN000125 AK131211 BI559602 AA913691 AA649629 

    GeneLoc Exon Structure


    Expression
    for TMPRSS7 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TMPRSS7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See TMPRSS7 Protein Expression from SPIRE MOPED and PaxDB
    SOURCE GeneReport for Unigene cluster: Hs.435490

    UniProtKB/Swiss-Prot: TMPS7_HUMAN, Q7RTY8
    Tissue specificity: Expressed in brain, ovary, testis, salivary gland, trachea and lung

        SABiosciences Custom PCR Arrays for TMPRSS7
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMPRSS7

    Orthologs
    for TMPRSS7 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for TMPRSS7 gene from 4/18 species (see all 18)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves TMPRSS71 transmembrane protease, serine 7 71.08(n)
    67.92(a)    		   769974  XM_001233290.2  XP_001233291.1 
    lizard
    (Anolis carolinensis)    		 Reptilia TMPRSS76
    		 --
    		 60(a)
    		 1 ↔ 1
    		 3(167654667-167678919)
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC7984801 transmembrane protease serine 7-like 56.1(n)
    50.42(a)    		   798480  XM_002666653.2  XP_002666699.2 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG16326
    		 --
    		 7(a)
    		 possible ortholog
    		 X(8146705-8166495)


    ENSEMBL Gene Tree for TMPRSS7 (if available)
    TreeFam Gene Tree for TMPRSS7 (if available) 

    Paralogs
    for TMPRSS7 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TMPRSS7 gene
    TMPRSS52  ST142  TMPRSS42  TMPRSS11D2  TMPRSS132  TMPRSS11E2  TMPRSS32  TMPRSS11B2  
    TMPRSS22  TMPRSS92  HPN2  TMPRSS152  TMPRSS11F2  TMPRSS11A2  TMPRSS62  
    18/59 SIMAP similar genes for TMPRSS7 using alignment to 4 protein entries:     TMPS7_HUMAN (see all proteins) (see all similar genes):
    PRSS1    F12    HP    PROC1    TMPRSS11D    PROC
    CELA2A    TMPRSS11E    CTRB1    CTRB2    PRSS45    F9
    DKFZp586F0824    PRSS2    TRY8    TMPRSS6    CELA2B    CTRC

    TMPRSS7 for paralogs           About GeneDecksing



    Genomic Variants
    for TMPRSS7 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/995 NCBI SNPs in TMPRSS7 are shown (see all 995)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 3 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs98622891,2
    		C,F,--111756471(+) cactaC/Tctccc 2 -- us2k12Minor allele frequency- T:0.19NA EA 240
    rs1383174731,2
    		--111756487(+) AAAATC/TGCTAA 2 -- us2k10--------
    rs1894912771,2
    		--111756510(+) GGTTTC/TGTGGC 2 -- us2k10--------
    rs1492284321,2
    		--111756552(+) GATGTC/TTTCCC 2 -- us2k10--------
    rs1432336891,2
    		--111756635(+) GAAAAC/TAGAAA 2 -- us2k10--------
    rs1390878311,2
    		--111756702(+) GGTTTA/GTATAC 2 -- us2k10--------
    rs1408855451,2
    		C,--111756816(+) AATAG-/TCATAT 2 -- us2k10--------
    rs1820579711,2
    		--111756838(+) AGTACA/CAACAT 2 -- us2k10--------
    rs1126146951,2
    		--111756921(+) AAGATA/GTCCAA 2 -- us2k12Minor allele frequency- G:0.09CSA WA 119
    rs43215071,2
    		C,F,--111756977(+) ACGACC/TACCGT 2 -- us2k11Minor allele frequency- T:0.05NA 120

    HapMap Linkage Disequilibrium report for TMPRSS7 (111753690 - 111800116 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for TMPRSS7: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMPRSS7
    DNA2.0 Custom Variant and Variant Library Synthesis for TMPRSS7

    Disorders / Diseases
    for TMPRSS7 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		   --

    Publications
    for TMPRSS7 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TMPRSS7 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with TMPRSS7)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Human and mouse proteases: a comparative genomic approach. (PubMed id 12838346)1, 2, 3 Puente X.S.... Lopez-Otin C. (2003)
    2. The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)1, 2 Muzny D.M....Gibbs R.A. (2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Matriptase-3 is a novel phylogenetically preserved membrane-anchored serine protease with broad serpin reactivity. (PubMed id 15853774)2 Szabo R....Bugge T.H. (2005)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    External Searches for TMPRSS7 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing TMPRSS7 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 344805 HGNC: 30846 AceView: TMPRSS7 Ensembl:ENSG00000176040 euGenes: HUgn344805
    ECgene: TMPRSS7 H-InvDB: TMPRSS7

    Other Databases showing TMPRSS7 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing TMPRSS7 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TMPRSS7 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for TMPRSS7 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for TMPRSS7 gene:
    Search GeneIP for patents involving TMPRSS7

    GeneCards and IP:
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     TMPRSS7 Proteins, Antibodies, CLIAs, and ELISAs
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     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMPRSS7
           
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