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Aliases for TMPRSS7 Gene

Aliases for TMPRSS7 Gene

  • Transmembrane Protease, Serine 7 2 3 5
  • Type II Transmembrane Serine Protease 7 2 3
  • Matriptase-3 3 4
  • Transmembrane Protease Serine 7 3
  • Transmembrane Serine Protease 7 3
  • EC 3.4.21.109 61
  • EC 3.4.21.9 61
  • EC 3.4.21.- 4
  • EC 3.4.21 61

External Ids for TMPRSS7 Gene

Previous GeneCards Identifiers for TMPRSS7 Gene

  • GC03P113034
  • GC03P113082
  • GC03P113241
  • GC03P111753
  • GC03P109133

Summaries for TMPRSS7 Gene

GeneCards Summary for TMPRSS7 Gene

TMPRSS7 (Transmembrane Protease, Serine 7) is a Protein Coding gene. GO annotations related to this gene include serine-type endopeptidase activity and serine-type peptidase activity. An important paralog of this gene is ST14.

UniProtKB/Swiss-Prot for TMPRSS7 Gene

  • Serine protease which preferentially hydrolyzes peptides with Arg at the P1 position.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMPRSS7 Gene

Genomics for TMPRSS7 Gene

Regulatory Elements for TMPRSS7 Gene

Enhancers for TMPRSS7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G112043 1 Ensembl ENCODE 8.3 +9.1 9058 0.6 CTCF SIN3A RAD21 RFX5 YY1 PATZ1 ZNF143 SMC3 PRDM10 DEK C3orf52 MIR567 ABHD10 TMPRSS7
GH03G112015 0.7 ENCODE 10.3 -20.8 -20835 0.2 CTCF TAF1 TRIM22 ZSCAN9 ZNF48 RAD21 KAT8 ZGPAT KLF16 NBN ABHD10 TMPRSS7 PLCXD2 RFKP2 TAGLN3
GH03G112014 0.9 ENCODE 6.1 -21.1 -21135 0.2 ELF3 FOXA2 ZFP64 SIN3A ARID4B ZSCAN9 ZNF48 RAD21 YY1 RARA ABHD10 TMPRSS7 RFKP2 TAGLN3
GH03G112031 0.4 ENCODE 12.5 -2.6 -2610 1.3 SMARCA4 TMPRSS7 RFKP2
GH03G112426 0.7 FANTOM5 ENCODE 2.4 +391.8 391815 0.4 EED CD200 BTLA TMPRSS7 LOC105374041
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMPRSS7 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMPRSS7 Gene

Chromosome:
3
Start:
112,034,843 bp from pter
End:
112,081,269 bp from pter
Size:
46,427 bases
Orientation:
Plus strand

Genomic View for TMPRSS7 Gene

Genes around TMPRSS7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMPRSS7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMPRSS7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMPRSS7 Gene

Proteins for TMPRSS7 Gene

  • Protein details for TMPRSS7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7RTY8-TMPS7_HUMAN
    Recommended name:
    Transmembrane protease serine 7
    Protein Accession:
    Q7RTY8
    Secondary Accessions:
    • C9J8P7
    • E9PAS3
    • Q17RH4

    Protein attributes for TMPRSS7 Gene

    Size:
    843 amino acids
    Molecular mass:
    94415 Da
    Quaternary structure:
    • Forms a heterodimer with SERPINA5.

    Alternative splice isoforms for TMPRSS7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMPRSS7 Gene

Selected DME Specific Peptides for TMPRSS7 Gene

Q7RTY8:
  • CPDGSDE
  • GDSGGPL
  • WPWQVSLH
  • TGIVSWG
  • CWVTGWG
  • CKGDSGG
  • WPWQVSL

Post-translational modifications for TMPRSS7 Gene

Other Protein References for TMPRSS7 Gene

Domains & Families for TMPRSS7 Gene

Gene Families for TMPRSS7 Gene

Suggested Antigen Peptide Sequences for TMPRSS7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7RTY8

UniProtKB/Swiss-Prot:

TMPS7_HUMAN :
  • Belongs to the peptidase S1 family.
Family:
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with TMPRSS7: view

Function for TMPRSS7 Gene

Molecular function for TMPRSS7 Gene

UniProtKB/Swiss-Prot Function:
Serine protease which preferentially hydrolyzes peptides with Arg at the P1 position.

Enzyme Numbers (IUBMB) for TMPRSS7 Gene

Gene Ontology (GO) - Molecular Function for TMPRSS7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004252 serine-type endopeptidase activity IEA --
GO:0008233 peptidase activity IEA --
GO:0008236 serine-type peptidase activity ISS --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with TMPRSS7: view
genes like me logo Genes that share phenotypes with TMPRSS7: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TMPRSS7

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMPRSS7 Gene

Localization for TMPRSS7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMPRSS7 Gene

Cell membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMPRSS7 gene
Compartment Confidence
plasma membrane 4
nucleus 2
cytosol 2

Gene Ontology (GO) - Cellular Components for TMPRSS7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane ISS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMPRSS7: view

Pathways & Interactions for TMPRSS7 Gene

SuperPathways for TMPRSS7 Gene

No Data Available

Interacting Proteins for TMPRSS7 Gene

Gene Ontology (GO) - Biological Process for TMPRSS7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis ISS --
genes like me logo Genes that share ontologies with TMPRSS7: view

No data available for Pathways by source and SIGNOR curated interactions for TMPRSS7 Gene

Transcripts for TMPRSS7 Gene

mRNA/cDNA for TMPRSS7 Gene

(3) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMPRSS7 Gene

Transmembrane protease, serine 7:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMPRSS7 Gene

No ASD Table

Relevant External Links for TMPRSS7 Gene

GeneLoc Exon Structure for
TMPRSS7
ECgene alternative splicing isoforms for
TMPRSS7

Expression for TMPRSS7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMPRSS7 Gene

mRNA differential expression in normal tissues according to GTEx for TMPRSS7 Gene

This gene is overexpressed in Testis (x19.4) and Pituitary (x4.2).

Protein differential expression in normal tissues from HIPED for TMPRSS7 Gene

This gene is overexpressed in Pancreatic juice (68.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TMPRSS7 Gene



Protein tissue co-expression partners for TMPRSS7 Gene

NURSA nuclear receptor signaling pathways regulating expression of TMPRSS7 Gene:

TMPRSS7

SOURCE GeneReport for Unigene cluster for TMPRSS7 Gene:

Hs.435490

mRNA Expression by UniProt/SwissProt for TMPRSS7 Gene:

Q7RTY8-TMPS7_HUMAN
Tissue specificity: Expressed in brain, ovary, testis, salivary gland, trachea and lung.
genes like me logo Genes that share expression patterns with TMPRSS7: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMPRSS7 Gene

Orthologs for TMPRSS7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMPRSS7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMPRSS7 34 35
  • 99.54 (n)
cow
(Bos Taurus)
Mammalia TMPRSS7 34 35
  • 90.66 (n)
dog
(Canis familiaris)
Mammalia TMPRSS7 34 35
  • 90.14 (n)
rat
(Rattus norvegicus)
Mammalia Tmprss7 34
  • 87.73 (n)
mouse
(Mus musculus)
Mammalia Tmprss7 34 16 35
  • 87.03 (n)
oppossum
(Monodelphis domestica)
Mammalia TMPRSS7 35
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMPRSS7 35
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMPRSS7 34 35
  • 71.18 (n)
lizard
(Anolis carolinensis)
Reptilia TMPRSS7 35
  • 60 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii LOC798480 34
  • 56.1 (n)
TMPRSS7 35
  • 46 (a)
OneToOne
Species where no ortholog for TMPRSS7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMPRSS7 Gene

ENSEMBL:
Gene Tree for TMPRSS7 (if available)
TreeFam:
Gene Tree for TMPRSS7 (if available)

Paralogs for TMPRSS7 Gene

Variants for TMPRSS7 Gene

Sequence variations from dbSNP and Humsavar for TMPRSS7 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000007863 -- 112,081,694(+) AAAAG(G/T)CTATT downstream-variant-500B
rs1000065862 -- 112,059,933(+) ATTAC(C/T)TATTG intron-variant
rs1000297756 -- 112,054,535(+) AGGGG(A/G)CTCAT intron-variant
rs1000356221 -- 112,080,077(+) GTTGG(A/C)ATTTT intron-variant
rs1000413375 -- 112,076,433(+) CCTGC(C/T)TATAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMPRSS7 Gene

Variant ID Type Subtype PubMed ID
dgv919e214 CNV gain 21293372
esv3597404 CNV loss 21293372
esv3597408 CNV loss 21293372

Variation tolerance for TMPRSS7 Gene

Residual Variation Intolerance Score: 95.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.36; 90.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMPRSS7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMPRSS7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMPRSS7 Gene

Disorders for TMPRSS7 Gene

Relevant External Links for TMPRSS7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMPRSS7

No disorders were found for TMPRSS7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMPRSS7 Gene

Publications for TMPRSS7 Gene

  1. Human and mouse proteases: a comparative genomic approach. (PMID: 12838346) Puente X.S. … Lopez-Otin C. (Nat. Rev. Genet. 2003) 2 3 4 64
  2. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny D.M. … Gibbs R.A. (Nature 2006) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Type II transmembrane serine protease gene variants associate with breast cancer. (PMID: 25029565) Luostari K. … Kosma V.M. (PLoS ONE 2014) 3 64

Products for TMPRSS7 Gene

Sources for TMPRSS7 Gene

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