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Aliases for TMPRSS6 Gene

Aliases for TMPRSS6 Gene

  • Transmembrane Protease, Serine 6 2 3
  • Matriptase-2 3 4
  • IRIDA 3 6
  • Membrane-Bound Mosaic Serine Proteinase Matriptase-2 3
  • Type II Transmembrane Serine Protease 6 3
  • Transmembrane Protease Serine 6 3
  • EC 3.4.21.- 4
  • EC 3.4.21 63

External Ids for TMPRSS6 Gene

Previous GeneCards Identifiers for TMPRSS6 Gene

  • GC22M034080
  • GC22P035703
  • GC22M035705
  • GC22M035706
  • GC22M035785
  • GC22M037461
  • GC22M020426

Summaries for TMPRSS6 Gene

Entrez Gene Summary for TMPRSS6 Gene

  • The protein encoded by this gene is a type II transmembrane serine proteinase that is found attached to the cell surface. The encoded protein may be involved in matrix remodeling processes in the liver. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

GeneCards Summary for TMPRSS6 Gene

TMPRSS6 is a Protein Coding gene. Diseases associated with TMPRSS6 include iron-refractory iron deficiency anemia and deficiency anemia. GO annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is HPN.

UniProtKB/Swiss-Prot for TMPRSS6 Gene

  • Serine protease which hydrolyzes a range of proteins including type I collagen, fibronectin and fibrinogen. Can also activate urokinase-type plasminogen activator with low efficiency. May play a specialized role in matrix remodeling processes in liver. Through the cleavage of HFE2, a regulator of the expression of the iron absorption-regulating hormone hepicidin/HAMP, plays a role in iron homeostasis.

Gene Wiki entry for TMPRSS6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMPRSS6 Gene

Genomics for TMPRSS6 Gene

Regulatory Elements for TMPRSS6 Gene

Genomic Location for TMPRSS6 Gene

37,065,436 bp from pter
37,109,672 bp from pter
44,237 bases
Minus strand

Genomic View for TMPRSS6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMPRSS6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMPRSS6 Gene

Proteins for TMPRSS6 Gene

  • Protein details for TMPRSS6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protease serine 6
    Protein Accession:
    Secondary Accessions:
    • B0QYB4
    • B0QYB7
    • B0QYB8
    • Q5TI06
    • Q6ICC2
    • Q6UXD8
    • Q8IUE2
    • Q8IXV8

    Protein attributes for TMPRSS6 Gene

    811 amino acids
    Molecular mass:
    90000 Da
    Quaternary structure:
    • Interacts with HFE2.

    Alternative splice isoforms for TMPRSS6 Gene


neXtProt entry for TMPRSS6 Gene

Proteomics data for TMPRSS6 Gene at MOPED

Selected DME Specific Peptides for TMPRSS6 Gene

Post-translational modifications for TMPRSS6 Gene

  • The single-chain zymogen undergoes autoproteolytic processing. This results in TMPRSS6 shedding from the cell surface and conversion into an activated two-chains form which is released extracellularly. The process involves a trans-activation mechanism that requires TMPRSS6 oligomerization.
  • Glycosylation at Asn127, Asn175, Asn207, Asn329, Asn424, Asn444, and Asn509
  • Modification sites at PhosphoSitePlus

Domains for TMPRSS6 Gene

Gene Families for TMPRSS6 Gene

  • TMPRSS :Serine peptidases / Transmembrane

Suggested Antigen Peptide Sequences for TMPRSS6 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q8IU80
  • Cytoplasmic domain mediates HAMP suppression via proximal promoter element(s).
  • Contains 2 CUB domains.
  • Contains 3 LDL-receptor class A domains.
  • Contains 1 peptidase S1 domain.
  • Contains 1 SEA domain.
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with TMPRSS6: view

Function for TMPRSS6 Gene

Molecular function for TMPRSS6 Gene

UniProtKB/Swiss-Prot Function: Serine protease which hydrolyzes a range of proteins including type I collagen, fibronectin and fibrinogen. Can also activate urokinase-type plasminogen activator with low efficiency. May play a specialized role in matrix remodeling processes in liver. Through the cleavage of HFE2, a regulator of the expression of the iron absorption-regulating hormone hepicidin/HAMP, plays a role in iron homeostasis.

Enzyme Numbers (IUBMB) for TMPRSS6 Gene

Gene Ontology (GO) - Molecular Function for TMPRSS6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004252 serine-type endopeptidase activity IDA 12149247
GO:0005515 protein binding IPI 19357398
genes like me logo Genes that share ontologies with TMPRSS6: view
genes like me logo Genes that share phenotypes with TMPRSS6: view

Animal Models for TMPRSS6 Gene

MGI Knock Outs for TMPRSS6:

miRNA for TMPRSS6 Gene

miRTarBase miRNAs that target TMPRSS6

No data available for Transcription Factor Targeting and HOMER Transcription for TMPRSS6 Gene

Localization for TMPRSS6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMPRSS6 Gene

Cell membrane; Single-pass type II membrane protein. Note=The processed, activated two-chains form is released in the extracellular space. {ECO:0000269 PubMed:25156943}.

Subcellular locations from

Jensen Localization Image for TMPRSS6 Gene COMPARTMENTS Subcellular localization image for TMPRSS6 gene
Compartment Confidence
plasma membrane 5
cytosol 1
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for TMPRSS6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 25156943
GO:0005886 plasma membrane IDA 19357398
GO:0016021 integral component of membrane IDA 12149247
genes like me logo Genes that share ontologies with TMPRSS6: view

Pathways for TMPRSS6 Gene

SuperPathways for TMPRSS6 Gene

No Data Available

Interacting Proteins for TMPRSS6 Gene

Gene Ontology (GO) - Biological Process for TMPRSS6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis NAS 12149247
GO:0006508 proteolysis IDA 12149247
GO:0030198 extracellular matrix organization NAS 12149247
GO:0030514 negative regulation of BMP signaling pathway IEA --
GO:0033619 membrane protein proteolysis IMP 25156943
genes like me logo Genes that share ontologies with TMPRSS6: view

No data available for Pathways by source for TMPRSS6 Gene

Compounds for TMPRSS6 Gene

(1) HMDB Compounds for TMPRSS6 Gene

Compound Synonyms Cas Number PubMed IDs
  • Armco iron

(2) Novoseek inferred chemical compound relationships for TMPRSS6 Gene

Compound -log(P) Hits PubMed IDs
serine 67.4 24
iron 31.7 16
genes like me logo Genes that share compounds with TMPRSS6: view

Transcripts for TMPRSS6 Gene

Unigene Clusters for TMPRSS6 Gene

Transmembrane protease, serine 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMPRSS6 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10

Relevant External Links for TMPRSS6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMPRSS6 Gene

mRNA expression in normal human tissues for TMPRSS6 Gene

mRNA differential expression in normal tissues according to GTEx for TMPRSS6 Gene

This gene is overexpressed in Liver (36.5) and Pituitary (4.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TMPRSS6 Gene

SOURCE GeneReport for Unigene cluster for TMPRSS6 Gene Hs.370885

mRNA Expression by UniProt/SwissProt for TMPRSS6 Gene

Tissue specificity: Liver specific.
genes like me logo Genes that share expressions with TMPRSS6: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for TMPRSS6 Gene

Orthologs for TMPRSS6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMPRSS6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMPRSS6 35
  • 99.36 (n)
  • 99.24 (a)
  • 99 (a)
(Bos Taurus)
Mammalia TMPRSS6 35
  • 88.25 (n)
  • 90.5 (a)
  • 90 (a)
(Canis familiaris)
Mammalia TMPRSS6 35
  • 90.54 (n)
  • 93.37 (a)
  • 93 (a)
(Mus musculus)
Mammalia Tmprss6 35
  • 83.83 (n)
  • 84.21 (a)
Tmprss6 16
Tmprss6 36
  • 83 (a)
(Monodelphis domestica)
Mammalia TMPRSS6 36
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia TMPRSS6 36
  • 62 (a)
(Rattus norvegicus)
Mammalia Tmprss6 35
  • 83.77 (n)
  • 85.05 (a)
(Gallus gallus)
Aves TMPRSS6 35
  • 71.36 (n)
  • 70.23 (a)
  • 68 (a)
(Anolis carolinensis)
Reptilia TMPRSS6 36
  • 56 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tmprss6 35
  • 59.35 (n)
  • 56.91 (a)
(Danio rerio)
Actinopterygii tmprss15 36
  • 18 (a)
Species with no ortholog for TMPRSS6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMPRSS6 Gene

Gene Tree for TMPRSS6 (if available)
Gene Tree for TMPRSS6 (if available)

Paralogs for TMPRSS6 Gene

genes like me logo Genes that share paralogs with TMPRSS6: view

Variants for TMPRSS6 Gene

Sequence variations from dbSNP and Humsavar for TMPRSS6 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs228892 -- 37,097,635(-) CAGGA(C/T)GGTGG intron-variant
rs228893 -- 37,097,645(-) CCCTC(C/T)GTTAC intron-variant
rs228894 -- 37,097,689(+) AGGAG(C/T)GGGCC intron-variant
rs228895 -- 37,097,701(+) CCGTC(C/T)TGTAA intron-variant
rs228896 -- 37,097,708(+) GTAAC(A/G)GAGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMPRSS6 Gene

Variant ID Type Subtype PubMed ID
nsv834187 CNV Loss 17160897
esv34015 CNV Loss 18971310
nsv459882 CNV Gain 19166990
nsv829203 CNV Loss 20364138
dgv4960n71 CNV Loss 21882294
nsv915015 CNV Loss 21882294
esv2724207 CNV Deletion 23290073
nsv915016 CNV Loss 21882294
esv24599 CNV Loss 19812545

Relevant External Links for TMPRSS6 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMPRSS6 Gene

Disorders for TMPRSS6 Gene

(1) OMIM Diseases for TMPRSS6 Gene (609862)


  • Iron-refractory iron deficiency anemia (IRIDA) [MIM:206200]: Key features include congenital hypochromic microcytic anemia, very low mean corpuscular erythrocyte volume, low transferrin saturation, abnormal iron absorption characterized by no hematologic improvement following treatment with oral iron, and abnormal iron utilization characterized by a sluggish, incomplete response to parenteral iron. {ECO:0000269 PubMed:18408718, ECO:0000269 PubMed:18603562, ECO:0000269 PubMed:19357398, ECO:0000269 PubMed:19592582, ECO:0000269 PubMed:19708871, ECO:0000269 PubMed:19747362, ECO:0000269 PubMed:20232450, ECO:0000269 PubMed:20704562, ECO:0000269 PubMed:21618415, ECO:0000269 PubMed:22581667, ECO:0000269 PubMed:25156943, ECO:0000269 PubMed:25588876}. Note=The disease is caused by mutations affecting the gene represented in this entry. Mutations leading to abrogation of TMPRSS6 activity are associated with IRIDA due to elevated levels of hepcidin, a negative regulator of plasma iron pool (PubMed:20232450). {ECO:0000269 PubMed:20232450}.

(3) University of Copenhagen DISEASES for TMPRSS6 Gene

(3) Novoseek inferred disease relationships for TMPRSS6 Gene

Disease -log(P) Hits PubMed IDs
iron deficiency anemia 72.8 4
breast cancer 0 9
tumors 0 2

Relevant External Links for TMPRSS6

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with TMPRSS6: view

Publications for TMPRSS6 Gene

  1. Matriptase-2, a membrane-bound mosaic serine proteinase predominantly expressed in human liver and showing degrading activity against extracellular matrix proteins. (PMID: 12149247) Velasco G. … Lopez-Otin C. (J. Biol. Chem. 2002) 3 4 23
  2. Refinement of the 22q12-q13 breast cancer--associated region: evidence of TMPRSS6 as a candidate gene in an eastern Finnish population. (PMID: 16533768) Hartikainen J.M. … Mannermaa A. (Clin. Cancer Res. 2006) 3 23 48
  3. The type II transmembrane serine protease matriptase-2 -- identification, structural features, enzymology, expression pattern and potential roles. (PMID: 17981570) Ramsay A.J. … Hooper J.D. (Front. Biosci. 2008) 3 4 23
  4. A mutation in the TMPRSS6 gene, encoding a transmembrane serine protease that suppresses hepcidin production, in familial iron deficiency anemia refractory to oral iron. (PMID: 18603562) Melis M.A. … Galanello R. (Haematologica 2008) 3 4 23
  5. Molecular mechanisms of the defective hepcidin inhibition in TMPRSS6 mutations associated with iron-refractory iron deficiency anemia. (PMID: 19357398) Silvestri L. … Grandchamp B. (Blood 2009) 3 4 23

Products for TMPRSS6 Gene

Sources for TMPRSS6 Gene

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