TMPRSS6 Gene
protein-coding GIFtS: 56
GCID: GC22M037461
|
|
transmembrane protease, serine 6
| |
Aliases
for TMPRSS6 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Transmembrane Protease, Serine 61 2 | | Transmembrane Protease Serine 62 | | IRIDA2 5 | | Type II Transmembrane Serine Protease 62 | | FLJ307441 | | EC 3.4.21.-3 | | Matriptase-23 | | Matriptase-23 | | Membrane-Bound Mosaic Serine Proteinase Matriptase-22 | | EC 3.4.218 |
Export aliases for TMPRSS6 gene to outside databasesPrevious GC identifers: GC22M034080 GC22P035703 GC22M035705 GC22M035706 GC22M035785 GC22M020426 |
Summaries
for TMPRSS6 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TMPRSS6:
The protein encoded by this gene is a type II transmembrane serine proteinase that is found attached to the cellsurface. The encoded protein may be involved in matrix remodeling processes in the liver. (provided by RefSeq, Jul2008)
UniProtKB/Swiss-Prot: TMPS6_HUMAN, Q8IU80Function: Serine protease which hydrolyzes a range of proteins including type I collagen, fibronectin and fibrinogen.Can also activate urokinase-type plasminogen activator with low efficiency. May play a specialized role in matrixremodeling processes in liver. Plays a role in the regulation of iron homeostasis, a process involving HAMP. Requiredto sense iron deficiency and suppress activation of the HAMP promoter
Gene Wiki entry for TMPRSS6
|
Genomic Views
for TMPRSS6 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000022.10 NC_018933.1 NT_011520.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TMPRSS6 gene promoter:
AP-1 GCNF-1 GCNF GCNF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for TMPRSS6
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMPRSS6 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 22q12.3 Ensembl cytogenetic band: 22q12.3 HGNC cytogenetic band: 22q13.1TMPRSS6 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 22 GeneLoc Exon Structure GeneLoc location for GC22M037461: view genomic region
(about GC identifiers)
Start:
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37,461,476 bp from pter |
End:
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37,505,603 bp from pter |
Size:
|
44,128 bases |
Orientation:
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minus strand |
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Proteins
for TMPRSS6 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TMPS6_HUMAN, Q8IU80 (See
protein sequence)Recommended Name: Transmembrane protease serine 6 Size: 811 amino acids; 90000 Da
Subunit: Interacts with HFE2
Subcellular location: Cell membrane; Single-pass type II membrane protein
Secondary accessions: B0QYB4 B0QYB7 B0QYB8 Q5TI06 Q6ICC2 Q6UXD8 Q8IUE2 Q8IXV8Alternative splicing: 4 isoforms: Q8IU80-4 Q8IU80-1 Q8IU80-2 Q8IU80-5 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for TMPRSS6: NX_Q8IU80
Post-translational modifications:
The single-chain zymogen undergoes proteolytic processing. This results in TMPRSS6 shedding from the cell surface andconversion into an activated two-chains form. The process involves a trans-activation mechanism that requires TMPRSS6oligomerization1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8IU80
4/5 DME Specific Peptides for TMPRSS6 (Q8IU80) (see all 5)
TMPRSS6 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_705837.1
ENSEMBL proteins: ENSP00000334962 ENSP00000385453 ENSP00000384964 ENSP00000392433 ENSP00000397691 ENSP00000400317 ENSP00000371211
Human Recombinant Protein Products for TMPRSS6:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
TMPRSS6 for ontologies About GeneDecksing
TMPRSS6 Antibody Products:
Assay Products for TMPRSS6: |
Protein
Domains /
Families
for TMPRSS6 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TMPRSS6 for domains About GeneDecksing
5/8 InterPro domains/families (see all 8):Graphical View of Domain Structure for InterPro Entry Q8IU80ProtoNet protein and cluster: Q8IU80 4 Blocks protein families: IPB000859 CUB domain IPB001254 Serine protease IPB001314 Chymotrypsin serine protease family (S1) signature IPB002172 Low density lipoprotein-receptor
UniProtKB/Swiss-Prot: TMPS6_HUMAN, Q8IU80Domain: Cytoplasmic domain mediates HAMP suppression via proximal promoter element(s) (By similarity)Similarity: Belongs to the peptidase S1 familySimilarity: Contains 2 CUB domainsSimilarity: Contains 3 LDL-receptor class A domainsSimilarity: Contains 1 peptidase S1 domain |
Function
for TMPRSS6 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: TMPS6_HUMAN, Q8IU80Function: Serine protease which hydrolyzes a range of proteins including type I collagen, fibronectin and fibrinogen.Can also activate urokinase-type plasminogen activator with low efficiency. May play a specialized role in matrixremodeling processes in liver. Plays a role in the regulation of iron homeostasis, a process involving HAMP. Requiredto sense iron deficiency and suppress activation of the HAMP promoter Enzyme Numbers (IUBMB): EC 3.4.212 EC 3.4.21.-1
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
TMPRSS6 for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for TMPRSS6:
12 MGI mutant phenotypes (inferred from 5 alleles ) (MGI details for Tmprss6):
TMPRSS6 for phenotypes About GeneDecksing
Animal Models:
Mouse knock-outs for TMPRSS6: Tmprss6tm1Otin Tmprss6tm1Dgen
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMPRSS6 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMPRSS6
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TMPRSS6 (NM_153609) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMPRSS6 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMPRSS6 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMPRSS6 |
|
Pathways & Interactions
for TMPRSS6 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMPRSS6
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
3 Interacting proteins for TMPRSS6 (Q8IU803 ENSP000003349624) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table
TMPRSS6 for ontologies About GeneDecksing
|
Drugs & Compounds
for TMPRSS6 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
TMPRSS6 for compounds About GeneDecksing
 Browse Tocris compounds for TMPRSS6
1 HMDB Compound for TMPRSS6 About this table
| Compound | Synonyms |
CAS
# | PubMed Ids |
|---|
| Iron | Armco iron (see all 19) | 7439-89-6 | -- |
2 Novoseek chemical compound relationships for TMPRSS6 gene About this table
Search CenterWatch for drugs/clinical trials and news about TMPRSS6 / TMPS6
|
Transcripts
for TMPRSS6 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TMPRSS6 gene: NM_153609.2 Unigene Cluster for TMPRSS6: Transmembrane protease, serine 6 Hs.370885 [show with all ESTs]Unigene Representative Sequence: NM_1536097 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000346753(uc003aqs.1) ENST00000406725 ENST00000406856(uc003aqt.1)
ENST00000429068 ENST00000442782(uc003aqu.3) ENST00000423761 ENST00000381792
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMPRSS6 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMPRSS6
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TMPRSS6 (NM_153609) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMPRSS6 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMPRSS6 |
Additional cDNA sequence: AJ319876.1 AY055384.1 AY358398.1 BC039082.1 BX538007.1 CR456446.1 6 DOTS entries: DT.40192033 DT.101960030 DT.100678217 DT.120671204 DT.95203999 DT.75113030 22 AceView cDNA sequences: NM_153609 AY358398 AW183485 AW168025 AY055384 AW295507 CR456446 BC039082 AW205177 AJ319876 NM_153019 AW182309 AV693114 BI832330 T68957 BE218064 AA609066 CB054579 BF379292 AV697553 T68884 AI912086
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for TMPRSS6 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 |
|---|
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| SP1: | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for TMPRSS6
|
Expression
for TMPRSS6 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TMPRSS6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGTGTGCCG
About this image
See TMPRSS6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TMPRSS6
SOURCE GeneReport for Unigene cluster: Hs.370885
UniProtKB/Swiss-Prot: TMPS6_HUMAN, Q8IU80Tissue specificity: Liver specific
SABiosciences Custom PCR Arrays for TMPRSS6
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMPRSS6
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TMPRSS6 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMPRSS6 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMPRSS6 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMPRSS6 |
Orthologs
for TMPRSS6 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for TMPRSS6 gene from 4/18 species (see all 18) About this table
ENSEMBL Gene Tree for TMPRSS6 (if available)
TreeFam Gene Tree for TMPRSS6 (if available) |
Paralogs
for TMPRSS6 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TMPRSS6 gene
- TMPRSS72 TMPRSS52 ST142 TMPRSS42 TMPRSS11D2 TMPRSS132 TMPRSS11E2 TMPRSS32
- TMPRSS11B2 TMPRSS22 TMPRSS92 HPN2 TMPRSS152 TMPRSS11F2 TMPRSS11A2
18/34 SIMAP similar genes for TMPRSS6 using alignment to 3 protein entries: TMPS6_HUMAN (see all proteins)
(see all similar genes):PRSS22 PRSS27 KLK3 PRSS48 TMPRSS12 TMPRSS7
KLK4 KLK7 PRSS2 TRY8 KLK13 CTRB2
ELANE KLK1 KLK9 PRSS3 TPSAB1 TPSB2
TMPRSS6 for paralogs About GeneDecksing
|
Genomic Variants
for TMPRSS6 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 22 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TMPRSS6 (37461476 - 37505603 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for TMPRSS6
1 CNV: 47855
1 Indel: 73821
Human Gene Mutation Database (HGMD): TMPRSS6
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMPRSS6 |
|
Disorders
/ Diseases
for TMPRSS6 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TMPRSS6 for disorders About GeneDecksing
OMIM gene information: 609862
OMIM disorders: 206200
UniProtKB/Swiss-Prot: TMPS6_HUMAN, Q8IU80
Defects in TMPRSS6 are the cause of iron-refractory iron deficiency anemia (IRIDA) [MIM:206200]; also known ashypochromic microcytic anemia with defect in iron metabolism or hereditary iron-handling disorder orpseudo-iron-deficiency anemia. Key features include congenital hypochromic microcytic anemia, very low meancorpuscular erythrocyte volume, low transferrin saturation, abnormal iron absorption characterized by no hematologicimprovement following treatment with oral iron, and abnormal iron utilization characterized by a sluggish, incompleteresponse to parenteral iron. Note=Mutations leading to abrogation of TMPRSS6 activity are associated with IRIDA due toelevated levels of hepcidin, a negative regulator of plasma iron pool (PubMed:20232450)
11  diseases for TMPRSS6: About MalaCardsiron-refractory iron deficiency anemia iron deficiency anemia hypochromic microcytic anemia microcytic anemia
iron overload anemia hemochromatosis breast cancer
prostate cancer hypoxia prostatitis
3 diseases from the University of Copenhagen DISEASES database for TMPRSS6:Iron deficiency anemia Hypochromic microcytic anemia Hemochromatosis 3 Novoseek disease relationships for TMPRSS6 gene About this table
Human Genome Epidemiology (HuGE) Navigator: TMPRSS6 (11 documents)
Export disorders for TMPRSS6 gene to outside databases
|
Publications
for TMPRSS6 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TMPRSS6 gene, integrated from 9 sources (see all 66):
(articles sorted by number of sources associating them with TMPRSS6) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Matriptase-2 mutations in iron-refractory iron defici ency anemia patients provide new insights into protease activation mechanisms. (PubMed id 19592582)1, 2, 9 Ramsay A.J....LA^pez-OtA-n C. (2009)
- Matriptase-2, a membrane-bound mosaic serine proteinase predominantly expressed in human liver and showing degrading activity against extracellular matrix proteins. (PubMed id 12149247)1, 2, 9 Velasco G.... Lopez-Otin C. (2002)
- A mutation in the TMPRSS6 gene, encoding a transmembrane serine protease that suppresses hepcidin production, in familial iron deficiency anemia refractory to oral iron. (PubMed id 18603562)1, 2, 9 Melis M.A....Galanello R. (2008)
- Molecular mechanisms of the defective hepcidin inhibi tion in TMPRSS6 mutations associated with iron-refractory iron deficiency anemi a. (PubMed id 19357398)1, 2, 9 Silvestri L....Grandchamp B. (2009)
- Haematologic data, iron parameters and molecular find ings in two new cases of iron-refractory iron deficiency anaemia. (PubMed id 19708871)1, 2, 9 Tchou I....Beris P. (2009)
- The type II transmembrane serine protease matriptase-2 -- identification, structural features, enzymology, expression pattern and potential roles. (PubMed id 17981570)1, 2, 9 Ramsay A.J.... Hooper J.D. (2008)
- Novel TMPRSS6 mutations associated with iron-refracto ry iron deficiency anemia (IRIDA). (PubMed id 20232450)1, 2, 9 De Falco L....Iolascon A. (2010)
- A novel mutation Gly603Arg of TMPRSS6 in a Korean fema le with iron-refractory iron deficiency anemia. (PubMed id 21618415)1, 2 Choi H.S....Kim H.J. (2012)
- Inactive matriptase-2 mutants found in IRIDA patients still repress hepcidin in a transfection assay despite having lost their serine protease activity. (PubMed id 22581667)1, 2 Guillem F.... Nicolas G. (2012)
- Polymorphisms and mutations of human TMPRSS6 in iron deficiency anemia. (PubMed id 19818657)1, 2 Beutler E....Lee P.L. (2010)
|
External Searches for TMPRSS6 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TMPRSS6 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TMPRSS6 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TMPRSS6 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TMPRSS6 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TMPRSS6 gene:
Search GeneIP for patents involving TMPRSS6
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TMPRSS6 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TMPRSS6 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMPRSS6 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMPRSS6 | | | OriGene Protein Over-expression Lysate for TMPRSS6 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TMPRSS6 | | OriGene 3'-UTR Clone for TMPRSS6 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMPRSS6 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMPRSS6 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TMPRSS6 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMPRSS6 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMPRSS6 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMPRSS6 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMPRSS6 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMPRSS6 |
| |
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| |  |  |  |  | | | | |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMPRSS6 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMPRSS6 |
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