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Aliases for TMPRSS5 Gene

Aliases for TMPRSS5 Gene

  • Transmembrane Protease, Serine 5 2 3 5
  • Spinesin 2 3 4
  • Transmembrane Protease Serine 5 3
  • EC 61
  • EC 3.4.21.- 4
  • EC 3.4.21 61

External Ids for TMPRSS5 Gene

Previous GeneCards Identifiers for TMPRSS5 Gene

  • GC11M115911
  • GC11M115070
  • GC11M113095
  • GC11M113063
  • GC11M109486
  • GC11M113558

Summaries for TMPRSS5 Gene

Entrez Gene Summary for TMPRSS5 Gene

  • This gene encodes a protein that belongs to the serine protease family. Serine proteases are known to be involved in many physiological and pathological processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

GeneCards Summary for TMPRSS5 Gene

TMPRSS5 (Transmembrane Protease, Serine 5) is a Protein Coding gene. GO annotations related to this gene include serine-type endopeptidase activity and scavenger receptor activity. An important paralog of this gene is TMPRSS2.

UniProtKB/Swiss-Prot for TMPRSS5 Gene

  • May play a role in hearing.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMPRSS5 Gene

Genomics for TMPRSS5 Gene

Regulatory Elements for TMPRSS5 Gene

Enhancers for TMPRSS5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F113662 1.3 Ensembl ENCODE 8.7 +50.1 50084 3.5 PKNOX1 ATF1 ARNT CREB3L1 ZNF133 FEZF1 GATA2 NCOA1 TSHZ1 CREB3 TMPRSS5 LRRC37A13P DRD2 MTRF1LP1 LOC105369501
GH11F113680 1.2 FANTOM5 ENCODE 5.9 +33.1 33078 1.5 PKNOX1 CBX3 FEZF1 ZBTB40 ZNF488 TSHZ1 HDAC8 ZNF843 MEF2D TFDP1 DRD2 LRRC37A13P LOC105369499 TTC12 TMPRSS5 MTRF1LP1 LOC105369501
GH11F113705 0.6 ENCODE 11.2 +8.5 8461 1.6 SOX13 SOX5 PKNOX1 RFX1 ZNF48 PPARG ZNF335 RFX3 SMAD4 TMPRSS5 LRRC37A13P DRD2 MTRF1LP1 LOC105369501
GH11F113725 0.5 ENCODE 8.5 -11.4 -11393 1.2 CTCF REST TRIM28 LOC105369499 TTC12 RNU6-1107P TMPRSS5 RPS29P19
GH11F113613 0.7 Ensembl 5.6 +100.9 100885 0.9 L3MBTL2 ZNF175 BACH1 ELF1 POLR2H IKZF1 ZNF512 ZSCAN29 SPI1 NR2C2 TMPRSS5 MTRF1LP1 LOC105369501
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMPRSS5 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMPRSS5 Gene

113,687,546 bp from pter
113,714,727 bp from pter
27,182 bases
Minus strand

Genomic View for TMPRSS5 Gene

Genes around TMPRSS5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMPRSS5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMPRSS5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMPRSS5 Gene

Proteins for TMPRSS5 Gene

  • Protein details for TMPRSS5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protease serine 5
    Protein Accession:

    Protein attributes for TMPRSS5 Gene

    457 amino acids
    Molecular mass:
    49560 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMPRSS5 Gene

Selected DME Specific Peptides for TMPRSS5 Gene


Post-translational modifications for TMPRSS5 Gene

  • Glycosylation at Asn 163, Asn 170, Asn 195, Asn 319, and Asn 375
  • Modification sites at PhosphoSitePlus

Domains & Families for TMPRSS5 Gene

Gene Families for TMPRSS5 Gene

Suggested Antigen Peptide Sequences for TMPRSS5 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 peptidase S1 domain.
  • Belongs to the peptidase S1 family.
  • Contains 1 peptidase S1 domain.
  • Contains 1 SRCR domain.
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with TMPRSS5: view

Function for TMPRSS5 Gene

Molecular function for TMPRSS5 Gene

UniProtKB/Swiss-Prot Function:
May play a role in hearing.

Enzyme Numbers (IUBMB) for TMPRSS5 Gene

Gene Ontology (GO) - Molecular Function for TMPRSS5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004252 serine-type endopeptidase activity IEA --
GO:0005044 scavenger receptor activity IEA --
GO:0008233 peptidase activity IEA,IMP 17918732
GO:0008236 serine-type peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with TMPRSS5: view
genes like me logo Genes that share phenotypes with TMPRSS5: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TMPRSS5

miRNA for TMPRSS5 Gene

miRTarBase miRNAs that target TMPRSS5

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMPRSS5 Gene

Localization for TMPRSS5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMPRSS5 Gene

Cell membrane; Single-pass type II membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMPRSS5 gene
Compartment Confidence
plasma membrane 5
extracellular 2
nucleus 1

Gene Ontology (GO) - Cellular Components for TMPRSS5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA,IDA 17918732
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0043025 neuronal cell body IEA --
genes like me logo Genes that share ontologies with TMPRSS5: view

Pathways & Interactions for TMPRSS5 Gene

SuperPathways for TMPRSS5 Gene

No Data Available

Interacting Proteins for TMPRSS5 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: Q9H3S3-TMPS5_HUMAN ENSP00000299882 for TMPRSS5 Gene via IID STRING

Gene Ontology (GO) - Biological Process for TMPRSS5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA,IMP 17918732
GO:0006898 receptor-mediated endocytosis IEA --
genes like me logo Genes that share ontologies with TMPRSS5: view

No data available for Pathways by source and SIGNOR curated interactions for TMPRSS5 Gene

Transcripts for TMPRSS5 Gene

Unigene Clusters for TMPRSS5 Gene

Transmembrane protease, serine 5:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMPRSS5 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - - - - - -
SP4: - - - - -
SP5: -
SP7: -

Relevant External Links for TMPRSS5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMPRSS5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TMPRSS5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMPRSS5 Gene

This gene is overexpressed in Nerve - Tibial (x8.9) and Brain - Substantia nigra (x4.5).

Protein differential expression in normal tissues from HIPED for TMPRSS5 Gene

This gene is overexpressed in Fetal gut (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMPRSS5 Gene

Protein tissue co-expression partners for TMPRSS5 Gene

NURSA nuclear receptor signaling pathways regulating expression of TMPRSS5 Gene:


SOURCE GeneReport for Unigene cluster for TMPRSS5 Gene:


mRNA Expression by UniProt/SwissProt for TMPRSS5 Gene:

Tissue specificity: Brain-specific. Predominantly expressed in neurons, in their axons, and at the synapses of motoneurons in the spinal cord.
genes like me logo Genes that share expression patterns with TMPRSS5: view

Primer Products

Orthologs for TMPRSS5 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMPRSS5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMPRSS5 34
  • 95.51 (n)
(Canis familiaris)
Mammalia TMPRSS5 34 35
  • 84.51 (n)
(Bos Taurus)
Mammalia TMPRSS5 34 35
  • 81.7 (n)
(Rattus norvegicus)
Mammalia Tmprss5 34
  • 81.41 (n)
(Mus musculus)
Mammalia Tmprss5 34 16 35
  • 80.66 (n)
(Monodelphis domestica)
Mammalia TMPRSS5 35
  • 51 (a)
(Gallus gallus)
Aves TMPRSS5 34 35
  • 64.88 (n)
(Anolis carolinensis)
Reptilia TMPRSS5 35
  • 44 (a)
(Danio rerio)
Actinopterygii LOC569688 34
  • 58.46 (n)
  • 37 (a)
fruit fly
(Drosophila melanogaster)
Insecta Try29F 36
  • 39 (a)
CG4613 36
  • 38 (a)
CG4386 36
  • 37 (a)
CG8170 36
  • 37 (a)
CG18735 36
  • 36 (a)
CG6041 36
  • 36 (a)
CG4914 36
  • 35 (a)
CG6048 36
  • 35 (a)
CG10405 36
  • 34 (a)
CG10663 36
  • 34 (a)
Tequila 36
  • 34 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004770 34
  • 30.52 (n)
Species where no ortholog for TMPRSS5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMPRSS5 Gene

Gene Tree for TMPRSS5 (if available)
Gene Tree for TMPRSS5 (if available)

Paralogs for TMPRSS5 Gene

genes like me logo Genes that share paralogs with TMPRSS5: view

Variants for TMPRSS5 Gene

Sequence variations from dbSNP and Humsavar for TMPRSS5 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs10544847 -- 113,698,252(+) CAAAC(-/CAAA)CAGAC intron-variant
rs10891587 -- 113,698,853(+) AGCTG(G/T)GACAG intron-variant
rs10891588 -- 113,708,876(+) ATGTA(C/T)GCACA nc-transcript-variant, utr-variant-5-prime
rs10891589 -- 113,709,115(+) ACTAG(A/C)TGAAC nc-transcript-variant, utr-variant-5-prime
rs1104693 -- 113,703,989(-) CCTCA(A/G)TGAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMPRSS5 Gene

Variant ID Type Subtype PubMed ID
esv3627779 CNV loss 21293372
nsv951072 CNV deletion 24416366

Variation tolerance for TMPRSS5 Gene

Gene Damage Index Score: 4.09; 61.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMPRSS5 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMPRSS5 Gene

Disorders for TMPRSS5 Gene


  • Note=Defects in TMPRSS5 may be a cause of deafness. {ECO:0000269 PubMed:17918732}.

Relevant External Links for TMPRSS5

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TMPRSS5 Gene.

No data available for MalaCards and Genatlas for TMPRSS5 Gene

Publications for TMPRSS5 Gene

  1. Spinesin/TMPRSS5, a novel transmembrane serine protease, cloned from human spinal cord. (PMID: 11741986) Yamaguchi N. … Mitsui S. (J. Biol. Chem. 2002) 3 4 22 64
  2. An integrated genetic and functional analysis of the role of type II transmembrane serine proteases (TMPRSSs) in hearing loss. (PMID: 17918732) Guipponi M. … Scott H.S. (Hum. Mutat. 2008) 3 4 64
  3. Genetic analysis of the pathogenic molecular sub-phenotype interferon-alpha identifies multiple novel loci involved in systemic lupus erythematosus. (PMID: 25338677) Kariuki S.N. … Niewold T.B. (Genes Immun. 2015) 3 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 4 64

Products for TMPRSS5 Gene

Sources for TMPRSS5 Gene

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