Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TMPRSS5 Gene

Aliases for TMPRSS5 Gene

  • Transmembrane Protease, Serine 5 2 3 5
  • SPINESIN 3 4
  • EC 3.4.21.4 63
  • EC 3.4.21.- 4
  • EC 3.4.21 63
  • Spinesin 2

External Ids for TMPRSS5 Gene

Previous GeneCards Identifiers for TMPRSS5 Gene

  • GC11M115911
  • GC11M115070
  • GC11M113095
  • GC11M113063
  • GC11M109486
  • GC11M113558

Summaries for TMPRSS5 Gene

Entrez Gene Summary for TMPRSS5 Gene

  • This gene encodes a protein that belongs to the serine protease family. Serine proteases are known to be involved in many physiological and pathological processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

GeneCards Summary for TMPRSS5 Gene

TMPRSS5 (Transmembrane Protease, Serine 5) is a Protein Coding gene. GO annotations related to this gene include serine-type endopeptidase activity and scavenger receptor activity. An important paralog of this gene is TMPRSS11A.

UniProtKB/Swiss-Prot for TMPRSS5 Gene

  • May play a role in hearing.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMPRSS5 Gene

Genomics for TMPRSS5 Gene

Regulatory Elements for TMPRSS5 Gene

Genomic Location for TMPRSS5 Gene

Chromosome:
11
Start:
113,687,546 bp from pter
End:
113,714,727 bp from pter
Size:
27,182 bases
Orientation:
Minus strand

Genomic View for TMPRSS5 Gene

Genes around TMPRSS5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMPRSS5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMPRSS5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMPRSS5 Gene

Proteins for TMPRSS5 Gene

  • Protein details for TMPRSS5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H3S3-TMPS5_HUMAN
    Recommended name:
    Transmembrane protease serine 5
    Protein Accession:
    Q9H3S3

    Protein attributes for TMPRSS5 Gene

    Size:
    457 amino acids
    Molecular mass:
    49560 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMPRSS5 Gene

Proteomics data for TMPRSS5 Gene at MOPED

Selected DME Specific Peptides for TMPRSS5 Gene

Post-translational modifications for TMPRSS5 Gene

  • Glycosylation at Asn 163, Asn 170, Asn 195, Asn 319, and Asn 375
  • Modification sites at PhosphoSitePlus

Antibody Products

Domains & Families for TMPRSS5 Gene

Gene Families for TMPRSS5 Gene

Suggested Antigen Peptide Sequences for TMPRSS5 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H3S3

UniProtKB/Swiss-Prot:

TMPS5_HUMAN :
  • Contains 1 peptidase S1 domain.
  • Belongs to the peptidase S1 family.
Domain:
  • Contains 1 peptidase S1 domain.
  • Contains 1 SRCR domain.
Family:
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with TMPRSS5: view

Function for TMPRSS5 Gene

Molecular function for TMPRSS5 Gene

UniProtKB/Swiss-Prot Function:
May play a role in hearing.

Enzyme Numbers (IUBMB) for TMPRSS5 Gene

genes like me logo Genes that share phenotypes with TMPRSS5: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TMPRSS5

CRISPR Products

miRNA for TMPRSS5 Gene

miRTarBase miRNAs that target TMPRSS5

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMPRSS5 Gene

Localization for TMPRSS5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMPRSS5 Gene

Cell membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMPRSS5 Gene COMPARTMENTS Subcellular localization image for TMPRSS5 gene
Compartment Confidence
plasma membrane 5
extracellular 2
nucleus 1

Gene Ontology (GO) - Cellular Components for TMPRSS5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMPRSS5: view

Pathways & Interactions for TMPRSS5 Gene

SuperPathways for TMPRSS5 Gene

No Data Available

Interacting Proteins for TMPRSS5 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000299882%0d%0a9606.ENSP00000368924%0d%0a
Selected Interacting proteins: ENSP00000299882 for TMPRSS5 Gene via STRING

Symbol External ID(s) Details
--

Gene Ontology (GO) - Biological Process for TMPRSS5 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMPRSS5 Gene

Drugs & Compounds for TMPRSS5 Gene

No Compound Related Data Available

Transcripts for TMPRSS5 Gene

Unigene Clusters for TMPRSS5 Gene

Transmembrane protease, serine 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMPRSS5 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - - - - - -
SP4: - - - - -
SP5: -
SP6:
SP7: -

Relevant External Links for TMPRSS5 Gene

GeneLoc Exon Structure for
TMPRSS5
ECgene alternative splicing isoforms for
TMPRSS5

Expression for TMPRSS5 Gene

mRNA expression in normal human tissues for TMPRSS5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMPRSS5 Gene

This gene is overexpressed in Nerve - Tibial (x8.9) and Brain - Substantia nigra (x4.5).

Protein differential expression in normal tissues from HIPED for TMPRSS5 Gene

This gene is overexpressed in Fetal gut (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMPRSS5 Gene



SOURCE GeneReport for Unigene cluster for TMPRSS5 Gene Hs.46720

mRNA Expression by UniProt/SwissProt for TMPRSS5 Gene

Q9H3S3-TMPS5_HUMAN
Tissue specificity: Brain-specific. Predominantly expressed in neurons, in their axons, and at the synapses of motoneurons in the spinal cord.
genes like me logo Genes that share expression patterns with TMPRSS5: view

Protein tissue co-expression partners for TMPRSS5 Gene

Primer Products

In Situ Assay Products

Orthologs for TMPRSS5 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMPRSS5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMPRSS5 35
  • 95.51 (n)
  • 94.31 (a)
cow
(Bos Taurus)
Mammalia TMPRSS5 36
  • 79 (a)
OneToOne
TMPRSS5 35
  • 81.7 (n)
  • 80 (a)
dog
(Canis familiaris)
Mammalia TMPRSS5 35
  • 84.51 (n)
  • 82.55 (a)
TMPRSS5 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmprss5 16
Tmprss5 36
  • 79 (a)
OneToOne
Tmprss5 35
  • 80.66 (n)
  • 79.23 (a)
oppossum
(Monodelphis domestica)
Mammalia TMPRSS5 36
  • 51 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmprss5 35
  • 81.41 (n)
  • 80.81 (a)
chicken
(Gallus gallus)
Aves TMPRSS5 35
  • 64.88 (n)
  • 58.57 (a)
TMPRSS5 36
  • 51 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMPRSS5 36
  • 44 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii TMPRSS5 36
  • 37 (a)
OneToOne
LOC569688 35
  • 58.46 (n)
  • 52.79 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004770 35
  • 30.52 (n)
  • 14.22 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10405 37
  • 34 (a)
CG10663 37
  • 34 (a)
CG18735 37
  • 36 (a)
CG4386 37
  • 37 (a)
CG4613 37
  • 38 (a)
CG4914 37
  • 35 (a)
CG6041 37
  • 36 (a)
CG6048 37
  • 35 (a)
CG8170 37
  • 37 (a)
Tequila 37
  • 34 (a)
Try29F 37
  • 39 (a)
Species with no ortholog for TMPRSS5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMPRSS5 Gene

ENSEMBL:
Gene Tree for TMPRSS5 (if available)
TreeFam:
Gene Tree for TMPRSS5 (if available)

Paralogs for TMPRSS5 Gene

genes like me logo Genes that share paralogs with TMPRSS5: view

Variants for TMPRSS5 Gene

Sequence variations from dbSNP and Humsavar for TMPRSS5 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
VAR_038005 -
rs11601425 - 113,699,663(+) CACGT(C/T)GCATG intron-variant, reference, missense
rs7939917 - 113,697,374(+) CCTCA(C/T)TTGCG nc-transcript-variant, reference, missense
VAR_038008 -
VAR_038009 -

Variation tolerance for TMPRSS5 Gene

Gene Damage Index Score: 4.09; 61.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMPRSS5 Gene

HapMap Linkage Disequilibrium report
TMPRSS5
Human Gene Mutation Database (HGMD)
TMPRSS5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TMPRSS5 Gene

Disorders for TMPRSS5 Gene

UniProtKB/Swiss-Prot

TMPS5_HUMAN
  • Note=Defects in TMPRSS5 may be a cause of deafness. {ECO:0000269 PubMed:17918732}.

Relevant External Links for TMPRSS5

Genetic Association Database (GAD)
TMPRSS5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMPRSS5

No disorders were found for TMPRSS5 Gene.

No data available for MalaCards and Genatlas for TMPRSS5 Gene

Publications for TMPRSS5 Gene

  1. Spinesin/TMPRSS5, a novel transmembrane serine protease, cloned from human spinal cord. (PMID: 11741986) Yamaguchi N. … Mitsui S. (J. Biol. Chem. 2002) 3 4 23 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Genetic analysis of the pathogenic molecular sub-phenotype interferon-alpha identifies multiple novel loci involved in systemic lupus erythematosus. (PMID: 25338677) Kariuki S.N. … Niewold T.B. (Genes Immun. 2015) 3
  4. An integrated genetic and functional analysis of the role of type II transmembrane serine proteases (TMPRSSs) in hearing loss. (PMID: 17918732) Guipponi M. … Scott H.S. (Hum. Mutat. 2008) 3
  5. Molecular cloning and tissue-specific expression analysis of mouse spinesin, a type II transmembrane serine protease 5. (PMID: 15465023) Watanabe Y. … Yamaguchi N. (Biochem. Biophys. Res. Commun. 2004) 23

Products for TMPRSS5 Gene

Sources for TMPRSS5 Gene

Back to Top

Content