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TMPRSS5 Gene

protein-coding   GIFtS: 50
GCID: GC11M113558

Transmembrane Protease, Serine 5

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Transmembrane Protease, Serine 51 2     EC 3.4.21.-3
spinesin1     Spinesin3
SPINESIN2     EC 3.4.218
Transmembrane Protease Serine 52     EC 3.4.21.48

External Ids:    HGNC: 149081   Entrez Gene: 809752   Ensembl: ENSG000001666827   OMIM: 6067515   UniProtKB: Q9H3S33   

Export aliases for TMPRSS5 gene to outside databases

Previous GC identifers: GC11M115911 GC11M115070 GC11M113592 GC11M113095 GC11M113063 GC11M109486


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TMPRSS5 Gene:
This gene encodes a protein that belongs to the serine protease family. Serine proteases are known to be involved
in many physiological and pathological processes. Alternative splicing results in multiple transcript variants.
(provided by RefSeq, Jan 2014)

GeneCards Summary for TMPRSS5 Gene:
TMPRSS5 (transmembrane protease, serine 5) is a protein-coding gene. GO annotations related to this gene include scavenger receptor activity and serine-type endopeptidase activity. An important paralog of this gene is TMPRSS11D.

UniProtKB/Swiss-Prot: TMPS5_HUMAN, Q9H3S3
Function: May play a role in hearing




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_033899.9  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TMPRSS5 gene promoter:
         STAT5B   STAT1   STAT4   STAT1beta   Pax-2   STAT5A   Pax-2a   STAT1alpha   STAT2   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMPRSS5 promoter sequence
   Search Chromatin IP Primers for TMPRSS5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TMPRSS5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q   Ensembl cytogenetic band:  11q23.2   HGNC cytogenetic band: 11q

TMPRSS5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMPRSS5 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M113558:  view genomic region     (about GC identifiers)

Start:
113,558,268 bp from pter      End:
113,577,095 bp from pter
Size:
18,828 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TMPS5_HUMAN, Q9H3S3 (See protein sequence)
Recommended Name: Transmembrane protease serine 5  
Size: 457 amino acids; 49560 Da

Explore the universe of human proteins at neXtProt for TMPRSS5: NX_Q9H3S3

Explore proteomics data for TMPRSS5 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn163, Asn170, Asn195, Asn319, Asn375
  • Selected DME Specific Peptides for TMPRSS5 (Q9H3S3) (see all 7)
     GDSGGPL  SGGPLVC  LVGVVSWG  CQGDSGGP 


    See TMPRSS5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001275678.1  NP_001275679.1  NP_001275680.1  NP_001275681.1  NP_110397.2  

    ENSEMBL proteins: 
     ENSP00000437937   ENSP00000437761   ENSP00000299882   ENSP00000441104   ENSP00000445528  
     ENSP00000440783   ENSP00000445930   ENSP00000443681   ENSP00000445502   ENSP00000440976  

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    Cloud-Clone Corp. Proteins for TMPRSS5

     
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    antibodies-online peptides for TMPRSS5

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TMPRSS: Serine peptidases / Transmembrane

    Selected InterPro protein domains (see all 6):
     IPR001314 Peptidase_S1A
     IPR001190 SRCR
     IPR009003 Trypsin-like_Pept_dom
     IPR017448 Srcr_rcpt-rel
     IPR001254 Peptidase_S1

    Graphical View of Domain Structure for InterPro Entry Q9H3S3

    ProtoNet protein and cluster: Q9H3S3

    2 Blocks protein domains:
    IPB001254 Serine protease
    IPB001314 Chymotrypsin serine protease family (S1) signature


    UniProtKB/Swiss-Prot: TMPS5_HUMAN, Q9H3S3
    Similarity: Belongs to the peptidase S1 family
    Similarity: Contains 1 peptidase S1 domain
    Similarity: Contains 1 SRCR domain


    Find genes that share domains with TMPRSS5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TMPS5_HUMAN, Q9H3S3
    Function: May play a role in hearing

         Enzyme Numbers (IUBMB): EC 3.4.21.42 EC 3.4.212 EC 3.4.21.-1

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004252serine-type endopeptidase activity IEA--
    GO:0005044scavenger receptor activity IEA--
    GO:0008233peptidase activity IMP17918732
         
    Find genes that share ontologies with TMPRSS5           About GenesLikeMe


    Animal Models:
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    3 qRT-PCR Assays for microRNAs that regulate TMPRSS5:
    hsa-miR-877* hsa-miR-766 hsa-miR-3918
    SwitchGear 3'UTR luciferase reporter plasmidTMPRSS5 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TMPRSS5

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    In Situ Assay
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TMPS5_HUMAN, Q9H3S3: Cell membrane; Single-pass type II membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular2
    golgi apparatus1
    nucleus1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IDA17918732
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--
    GO:0043025neuronal cell body IEA--

    Find genes that share ontologies with TMPRSS5           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TMPRSS5
    Interactions:

        Search GeneGlobe Interaction Network for TMPRSS5

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IMP17918732

    Find genes that share ontologies with TMPRSS5           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TMPRSS5 (TMPS5)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TMPRSS5 gene (5 alternative transcripts): 
    NM_001288749.1  NM_001288750.1  NM_001288751.1  NM_001288752.1  NM_030770.3  

    Unigene Cluster for TMPRSS5:

    Transmembrane protease, serine 5
    Hs.46720  [show with all ESTs]
    Unigene Representative Sequence: AF495727
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000536856 ENST00000540540 ENST00000299882(uc001poc.4 uc009yys.3 uc009yyt.3 uc001pod.4 uc010rww.2 uc009yyu.3 uc010rwx.2)
    ENST00000545579 ENST00000538955 ENST00000544634 ENST00000544476 ENST00000545265
    ENST00000545412 ENST00000539732 ENST00000538770 ENST00000538091
    miRNA
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    3 qRT-PCR Assays for microRNAs that regulate TMPRSS5:
    hsa-miR-877* hsa-miR-766 hsa-miR-3918
    SwitchGear 3'UTR luciferase reporter plasmidTMPRSS5 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TMPRSS5
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    GenScript: all cDNA clones in your preferred vector: TMPRSS5 (NM_030770)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMPRSS5
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TMPRSS5
      QuantiTect SYBR Green Assays in human, mouse, rat TMPRSS5
      QuantiFast Probe-based Assays in human, mouse, rat TMPRSS5

    Additional mRNA sequence: 

    AB028140.1 AF495727.1 AK294313.1 AK295366.1 BC028065.1 BC047222.1 BC121802.1 BC121803.1 

    5 DOTS entries:

    DT.101978242  DT.101978241  DT.107841  DT.100677419  DT.120706743 

    Selected AceView cDNA sequences (see all 35):

    AI597622 BF515139 BI757597 BC028065 CD516647 AL538140 BP346544 AI197773 
    CK004430 AI631456 BC047222 AI653241 BE222599 AI825589 BI601373 AI085672 
    NM_030770 AI826089 AI056603 AI201055 CB115630 BM977058 BQ575647 AI967938 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TMPRSS5 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
    SP1:                    -                 -                 -                 -     -                 -                           
    SP2:              -     -     -           -                 -                 -     -                                             
    SP3:              -     -     -     -     -                 -                 -     -                                             
    SP4:              -     -     -     -     -                                                                                       
    SP5:                                                                                                  -                           


    ECgene alternative splicing isoforms for TMPRSS5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TMPRSS5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTGAGAGGC
    TMPRSS5 Expression
    About this image


    TMPRSS5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Muscle Progenitor Cells Mandibular Arch Muscles
     
     Brain (Nervous System)
             Myelinating Oligodendrocyte Cells Forebrain White Matter
    TMPRSS5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TMPRSS5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.46720

    UniProtKB/Swiss-Prot: TMPS5_HUMAN, Q9H3S3
    Tissue specificity: Brain-specific. Predominantly expressed in neurons, in their axons, and at the synapses of
    motoneurons in the spinal cord

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TMPRSS5 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tmprss51 , 5 transmembrane protease, serine 5 (spinesin)1, 5 80.66(n)1
    79.23(a)1
      9 (26.59 cM)5
    808931  NM_030709.21  NP_109634.21 
     490812605 
    chicken
    (Gallus gallus)
    Aves TMPRSS51 transmembrane protease, serine 5 64.88(n)
    58.57(a)
      100859234  XM_003642614.2  XP_003642662.2 
    lizard
    (Anolis carolinensis)
    Reptilia TMPRSS56
    transmembrane protease, serine 5
    44(a)
    1 ↔ 1
    GL343354.1(307252-318507)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5696881 transmembrane protease serine 5-like 58.46(n)
    52.79(a)
      569688  XM_693087.5  XP_698179.4 
    mosquito
    (Anopheles gambiae)
    Insecta AgaP_AGAP0047701 AgaP_AGAP004770 30.52(n)
    14.22(a)
      1278456  XM_318046.4  XP_318046.3 


    ENSEMBL Gene Tree for TMPRSS5 (if available)
    TreeFam Gene Tree for TMPRSS5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TMPRSS5 gene
    TMPRSS11D2  TMPRSS32  TMPRSS11B2  TMPRSS62  TMPRSS11A2  TMPRSS72  TMPRSS42  ST142  
    TMPRSS132  TMPRSS11E2  KLKB12  TMPRSS22  F112  HPN2  TMPRSS152  TMPRSS11F2  
    Selected SIMAP similar genes for TMPRSS5 using alignment to 12 protein entries:     TMPS5_HUMAN (see all proteins) (see all similar genes):
    MGC52282    serase-1B    F12    CTRB2    DKFZp586F0824    CTRB1
    KLKB1    F11    TMPRSS3    ST14    DKFZp779M0222    PRSS22
    TMPRSS11D    TMPRSS11B    DESC1    TMPRSS11E    TMPRSS11F    ACR

    Find genes that share paralogs with TMPRSS5           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TMPRSS5 (see all 487)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1846003911,2
    C--113557876(+) ATTACA/CGGGGT 1 -- ds50010--------
    rs65893911,2
    C,A--113557891(+) caccgC/Tgccca 1 -- ds50013Minor allele frequency- T:0.14NS WA 36
    rs1493047891,2
    --113557925(+) TTAAAG/TAATTA 1 -- ds50010--------
    rs1903817781,2
    --113558046(+) AACATC/TGAGGC 1 -- ds50010--------
    rs1506562131,2
    C--113558209(+) GTTTG-/TGTC  
            
    TGTCT
    1 -- ds50010--------
    rs1120147561,2
    C--113558226(+) CTGTCC/TGTCTG 1 -- ds50011Minor allele frequency- T:0.50CSA 2
    rs171158211,2
    C,F,H--113558268(+) AAAACT/CGGACC 1 -- ut3123Minor allele frequency- C:0.09NA NS EA CSA WA 2496
    rs789361311,2
    C,F--113558371(+) TGTTTT/CCCAGT 1 -- ut311Minor allele frequency- C:0.02EA 120
    rs1932961831,2
    --113558419(+) GAACAA/GGAAGG 1 -- ut310--------
    rs764701591,2
    C,F--113558425(+) GAAGGG/CGAGTG 1 -- ut311Minor allele frequency- C:0.10WA 118

    HapMap Linkage Disequilibrium report for TMPRSS5 (113558268 - 113577095 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TMPRSS5: --
    Human Gene Mutation Database (HGMD): TMPRSS5
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TMPRSS5
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606751    OMIM disorders: --

    UniProtKB/Swiss-Prot: TMPS5_HUMAN, Q9H3S3
  • Note=Defects in TMPRSS5 may be a cause of deafness


  • Find genes that share disorders with TMPRSS5           About GenesLikeMe

    Genetic Association Database (GAD): TMPRSS5

    Export disorders for TMPRSS5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TMPRSS5 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with TMPRSS5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Spinesin/TMPRSS5, a novel transmembrane serine protease, cloned from human spinal cord. (PubMed id 11741986)1, 2, 9 Yamaguchi N.... Mitsui S. (J. Biol. Chem. 2002)
    2. An integrated genetic and functional analysis of the role of type II transmembrane serine proteases (TMPRSSs) in hearing loss. (PubMed id 17918732)1, 2 Guipponi M.... Scott H.S. (Hum. Mutat. 2008)
    3. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (Nature 2006)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    5. ADAM-9 is an insulin-like growth factor binding protein-5 protease produced and secreted by human osteoblasts. (PubMed id 12484779)1 Mohan S....Baylink D.J. (Biochemistry 2002)
    6. Molecular cloning and tissue-specific expression analysis of mouse spinesin, a type II transmembrane serine protease 5. (PubMed id 15465023)9 Watanabe Y....Yamaguchi N. (Biochem. Biophys. Res. Commun. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
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      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 80975 HGNC: 14908 AceView: TMPRSS5 Ensembl:ENSG00000166682 euGenes: HUgn80975
    ECgene: TMPRSS5 H-InvDB: TMPRSS5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TMPRSS5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TMPRSS5 gene:
    Search GeneIP for patents involving TMPRSS5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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