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Aliases for TMPRSS5 Gene

Aliases for TMPRSS5 Gene

  • Transmembrane Protease, Serine 5 2 3
  • SPINESIN 3 4
  • Transmembrane Protease Serine 5 3
  • EC 63
  • EC 3.4.21.- 4
  • EC 3.4.21 63
  • Spinesin 2

External Ids for TMPRSS5 Gene

Previous GeneCards Identifiers for TMPRSS5 Gene

  • GC11M115911
  • GC11M115070
  • GC11M113095
  • GC11M113063
  • GC11M109486
  • GC11M113558

Summaries for TMPRSS5 Gene

Entrez Gene Summary for TMPRSS5 Gene

  • This gene encodes a protein that belongs to the serine protease family. Serine proteases are known to be involved in many physiological and pathological processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

GeneCards Summary for TMPRSS5 Gene

TMPRSS5 is a Protein Coding gene. GO annotations related to this gene include serine-type endopeptidase activity and scavenger receptor activity. An important paralog of this gene is HPN.

UniProtKB/Swiss-Prot for TMPRSS5 Gene

  • May play a role in hearing.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMPRSS5 Gene

Genomics for TMPRSS5 Gene

Regulatory Elements for TMPRSS5 Gene

Genomic Location for TMPRSS5 Gene

113,687,546 bp from pter
113,706,429 bp from pter
18,884 bases
Minus strand

Genomic View for TMPRSS5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMPRSS5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMPRSS5 Gene

Proteins for TMPRSS5 Gene

  • Protein details for TMPRSS5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protease serine 5
    Protein Accession:
    Secondary Accessions:

    Protein attributes for TMPRSS5 Gene

    457 amino acids
    Molecular mass:
    49560 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMPRSS5 Gene

Proteomics data for TMPRSS5 Gene at MOPED

Selected DME Specific Peptides for TMPRSS5 Gene

Post-translational modifications for TMPRSS5 Gene

  • Glycosylation at Asn163, Asn170, Asn195, Asn319, and Asn375
  • Modification sites at PhosphoSitePlus

Antibody Products

Domains for TMPRSS5 Gene

Gene Families for TMPRSS5 Gene

  • TMPRSS :Serine peptidases / Transmembrane

Suggested Antigen Peptide Sequences for TMPRSS5 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q9H3S3
  • Contains 1 peptidase S1 domain.
  • Contains 1 SRCR domain.
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with TMPRSS5: view

Function for TMPRSS5 Gene

Molecular function for TMPRSS5 Gene

UniProtKB/Swiss-Prot Function:
May play a role in hearing.

Enzyme Numbers (IUBMB) for TMPRSS5 Gene

Gene Ontology (GO) - Molecular Function for TMPRSS5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004252 serine-type endopeptidase activity IEA --
GO:0005044 scavenger receptor activity IEA --
GO:0008233 peptidase activity IMP 17918732
genes like me logo Genes that share ontologies with TMPRSS5: view

Animal Model Products

CRISPR Products

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TMPRSS5 Gene

Localization for TMPRSS5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMPRSS5 Gene

Cell membrane; Single-pass type II membrane protein.

Subcellular locations from

Jensen Localization Image for TMPRSS5 Gene COMPARTMENTS Subcellular localization image for TMPRSS5 gene
Compartment Confidence
plasma membrane 5
extracellular 2
golgi apparatus 1
nucleus 1

Gene Ontology (GO) - Cellular Components for TMPRSS5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA 17918732
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
GO:0043025 neuronal cell body IEA --
genes like me logo Genes that share ontologies with TMPRSS5: view

Pathways for TMPRSS5 Gene

SuperPathways for TMPRSS5 Gene

No Data Available

Interacting Proteins for TMPRSS5 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000299882 for TMPRSS5 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for TMPRSS5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IMP 17918732
GO:0006898 receptor-mediated endocytosis IEA --
genes like me logo Genes that share ontologies with TMPRSS5: view

No data available for Pathways by source for TMPRSS5 Gene

Transcripts for TMPRSS5 Gene

Unigene Clusters for TMPRSS5 Gene

Transmembrane protease, serine 5:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMPRSS5

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMPRSS5 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - - - - - -
SP4: - - - - -
SP5: -
SP7: -

Relevant External Links for TMPRSS5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMPRSS5 Gene

mRNA expression in normal human tissues for TMPRSS5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMPRSS5 Gene

This gene is overexpressed in Nerve - Tibial (8.9) and Brain - Substantia nigra (4.5).

Protein differential expression in normal tissues for TMPRSS5 Gene

This gene is overexpressed in Fetal gut (69.0).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for TMPRSS5 Gene

SOURCE GeneReport for Unigene cluster for TMPRSS5 Gene Hs.46720

mRNA Expression by UniProt/SwissProt for TMPRSS5 Gene

Tissue specificity: Brain-specific. Predominantly expressed in neurons, in their axons, and at the synapses of motoneurons in the spinal cord
genes like me logo Genes that share expressions with TMPRSS5: view

Expression partners for TMPRSS5 Gene

In Situ Assay Products

Orthologs for TMPRSS5 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMPRSS5 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TMPRSS5 35
  • 81.7 (n)
  • 80 (a)
  • 79 (a)
(Canis familiaris)
Mammalia TMPRSS5 35
  • 84.51 (n)
  • 82.55 (a)
  • 81 (a)
(Mus musculus)
Mammalia Tmprss5 35
  • 80.66 (n)
  • 79.23 (a)
Tmprss5 16
Tmprss5 36
  • 79 (a)
(Pan troglodytes)
Mammalia TMPRSS5 35
  • 95.51 (n)
  • 94.31 (a)
(Rattus norvegicus)
Mammalia Tmprss5 35
  • 81.41 (n)
  • 80.81 (a)
(Monodelphis domestica)
Mammalia TMPRSS5 36
  • 51 (a)
(Gallus gallus)
Aves TMPRSS5 35
  • 64.88 (n)
  • 58.57 (a)
  • 51 (a)
(Anolis carolinensis)
Reptilia TMPRSS5 36
  • 44 (a)
(Danio rerio)
Actinopterygii LOC569688 35
  • 58.46 (n)
  • 52.79 (a)
  • 37 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10405 37
  • 34 (a)
CG10663 37
  • 34 (a)
CG18735 37
  • 36 (a)
CG4386 37
  • 37 (a)
CG4613 37
  • 38 (a)
CG4914 37
  • 35 (a)
CG6041 37
  • 36 (a)
CG6048 37
  • 35 (a)
CG8170 37
  • 37 (a)
Tequila 37
  • 34 (a)
Try29F 37
  • 39 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004770 35
  • 30.52 (n)
  • 14.22 (a)
Species with no ortholog for TMPRSS5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMPRSS5 Gene

Gene Tree for TMPRSS5 (if available)
Gene Tree for TMPRSS5 (if available)

Paralogs for TMPRSS5 Gene

genes like me logo Genes that share paralogs with TMPRSS5: view

Variants for TMPRSS5 Gene

Sequence variations from dbSNP and Humsavar for TMPRSS5 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs13606 -- 113,687,679(-) GCTGT(C/G)GCTGG utr-variant-3-prime, nc-transcript-variant
rs925267 -- 113,707,955(-) ACACA(C/T)GGTAG upstream-variant-2KB
rs967199 -- 113,707,235(-) ACAGT(C/T)TGTGC upstream-variant-2KB
rs1104693 -- 113,703,989(-) CCTCA(A/G)TGAGA intron-variant
rs1155104 -- 113,707,298(-) ACATT(C/T)AGCAA upstream-variant-2KB

Relevant External Links for TMPRSS5 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TMPRSS5 Gene

Disorders for TMPRSS5 Gene


  • Note=Defects in TMPRSS5 may be a cause of deafness.

Relevant External Links for TMPRSS5

Genetic Association Database (GAD)

No disorders were found for TMPRSS5 Gene.

No data available for MalaCards , OMIM , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for TMPRSS5 Gene

Publications for TMPRSS5 Gene

  1. Spinesin/TMPRSS5, a novel transmembrane serine protease, cloned from human spinal cord. (PMID: 11741986) Yamaguchi N. … Mitsui S. (J. Biol. Chem. 2002) 3 4 23
  2. An integrated genetic and functional analysis of the role of type II transmembrane serine proteases (TMPRSSs) in hearing loss. (PMID: 17918732) Guipponi M. … Scott H.S. (Hum. Mutat. 2008) 3 4
  3. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 4
  4. Molecular cloning and tissue-specific expression analysis of mouse spinesin, a type II transmembrane serine protease 5. (PMID: 15465023) Watanabe Y. … Yamaguchi N. (Biochem. Biophys. Res. Commun. 2004) 23
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for TMPRSS5 Gene

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