Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TMPRSS4 Gene

protein-coding GIFtS: 55
GCID: GC11P117981

transmembrane protease, serine 4

Explore 6 diseases affiliated with
TMPRSS4 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Transmembrane Protease, Serine 4¹ ²		Transmembrane Serine Protease 3²
MT-SP2¹ ² ³		Type II Membrane Serine Protease²
TMPRSS3¹ ² ³		EC 3.4.21.-³
Channel-Activating Protease 2² ³		EC 3.4.21⁸
Membrane-Type Serine Protease 2² ³		EC 3.4.21.4⁸
CAPH2² ³		EC 3.4.21.43⁸
Transmembrane Protease Serine 4²

External Ids:	HGNC: 11878¹	Entrez Gene: 56649²	Ensembl: ENSG00000137648⁷	OMIM: 606565⁵	UniProtKB: Q9NRS4³

Export aliases for TMPRSS4 gene to outside databases

Previous GC identifers: GC11P120304 GC11P119459 GC11P117485 GC11P117452 GC11P113881

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TMPRSS4:

This gene encodes a member of the serine protease family. Serine proteases are known to be involved in a variety of

biological processes, whose malfunction often leads to human diseases and disorders. This gene was identified as a

gene overexpressed in pancreatic carcinoma. The encoded protein is membrane bound with a N-terminal anchor sequence

and a glycosylated extracellular region containing the serine protease domain. Multiple transcript variants encoding

different isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: TMPS4_HUMAN, Q9NRS4

Function: Probable protease. Seems to be capable of activating ENaC (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_033899.8

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TMPRSS4 gene promoter:
GR AML1a Lmo2 POU3F2 C/EBPalpha CHOP-10 CREB deltaCREB GR-alpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TMPRSS4 promoter sequence

Search SABiosciences Chromatin IP Primers for TMPRSS4

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMPRSS4

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q23.3 Ensembl cytogenetic band: 11q23.3 HGNC cytogenetic band: 11q23.3

TMPRSS4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMPRSS4 gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P117981: view genomic region (about GC identifiers)

Start:	117,947,727 bp from pter	End:	117,992,605 bp from pter
Size:	44,879 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TMPS4_HUMAN, Q9NRS4 (See protein sequence)

Recommended Name: Transmembrane protease serine 4

Size: 437 amino acids; 48246 Da

Subcellular location: Membrane; Single-pass type II membrane protein (Potential)

Sequence caution: Sequence=AAF31436.1; Type=Frameshift; Positions=31;

Secondary accessions: A8MU84 B0YJB0 Q5XKQ6 Q6UX37 Q9NZA5

Alternative splicing: 3 isoforms: Q9NRS4-1 Q9NRS4-2 Q9NRS4-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TMPRSS4: NX_Q9NRS4

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9NRS4

4/8 DME Specific Peptides for TMPRSS4 (Q9NRS4) (see all 8)

GDSGGPL

PWQVSIQ

PGVYTKV

LTAAHCF

TMPRSS4 Protein expression data from MOPED and PaxDb: --

REFSEQ proteins (4 alternative transcripts):

NP_001077416.1 NP_001167022.1 NP_001167023.1 NP_063947.1

ENSEMBL proteins:

ENSP00000435184 ENSP00000429889 ENSP00000428814 ENSP00000429209 ENSP00000431062

ENSP00000416037 ENSP00000430547 ENSP00000428407 ENSP00000429833 ENSP00000428246

Human Recombinant Protein Products for TMPRSS4:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Proteins (see all 2): TMPRSS4 OriGene Protein Over-expression Lysate (see all 4): TMPRSS4 OriGene Custom Protein Services for TMPRSS4
	GenScript Custom Purified and Recombinant Proteins Services for TMPRSS4
	Novus Biologicals TMPRSS4 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for TMPRSS4

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016020	membrane	--	--
GO:0016021	integral to membrane	NAS	10825129

TMPRSS4 for ontologies About GeneDecksing

TMPRSS4 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	OriGene Antibodies (see all 2): TMPRSS4 OriGene Custom Antibody Services for TMPRSS4
	GenScript Custom Superior Antibodies Services for TMPRSS4
	Novus Biologicals TMPRSS4 Antibodies
	Abcam antibodies for TMPRSS4
	Uscn Antibodies for TMPRSS4
	ThermoFisher Antibodies for TMPRSS4

Assay Products for TMPRSS4:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for TMPRSS4
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for TMPRSS4

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TMPRSS4 for domains About GeneDecksing

5/7 InterPro domains/families (see all 7):

IPR002172 LDrepeatLR_classA_rpt

IPR001314 Peptidase_S1A

IPR001190 Srcr_rcpt

IPR009003 Trypsin-like_Pept_dom

IPR017448 Srcr_rcpt-rel

Graphical View of Domain Structure for InterPro Entry Q9NRS4

ProtoNet protein and cluster: Q9NRS4

3 Blocks protein families:

IPB001254 Serine protease

IPB001314 Chymotrypsin serine protease family (S1) signature

IPB002172 Low density lipoprotein-receptor

UniProtKB/Swiss-Prot: TMPS4_HUMAN, Q9NRS4

Similarity: Belongs to the peptidase S1 family

Similarity: Contains 1 LDL-receptor class A domain

Similarity: Contains 1 peptidase S1 domain

Similarity: Contains 1 SRCR domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: TMPS4_HUMAN, Q9NRS4

Function: Probable protease. Seems to be capable of activating ENaC (By similarity)

Enzyme Numbers (IUBMB): EC 3.4.21.43² EC 3.4.21.4² EC 3.4.21² EC 3.4.21.-¹

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003824	catalytic activity	--	--
GO:0004252	serine-type endopeptidase activity	NAS	10825129
GO:0005044	scavenger receptor activity	IEA	--

TMPRSS4 for ontologies About GeneDecksing

Phenotypes:
1 MGI phenotypic allele

for Tmprss4 (no phenotypes)

TMPRSS4 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Tmprss4^tm1Lex for TMPRSS4

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for TMPRSS4

miRNA Products:		OriGene 3'-UTR Clone (see all 2): TMPRSS4 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TMPRSS4
		4 QIAGEN miScript miRNA Assays for microRNAs that regulate TMPRSS4:
		hsa-miR-345 hsa-miR-769-5p hsa-miR-2116 hsa-miR-4277
		SwitchGear 3'UTR luciferase reporter plasmid: TMPRSS4 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMPRSS4 (see all 7) OriGene shRNA RFP: TMPRSS4 OriGene siRNA: TMPRSS4
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMPRSS4
		Sirion Biotech Custom design and validation of potent shRNA sequences against TMPRSS4

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for TMPRSS4
			Sirion Biotech Customized adenovirus for overexpression of TMPRSS4 Sirion Biotech Customized adenovirus for potent knockdown of TMPRSS4

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMPRSS4 (see all 7) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMPRSS4 (see all 5) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 4): TMPRSS4 (NM_019894)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMPRSS4
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMPRSS4

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for TMPRSS4
		Search LifeMap BioReagents cell lines for TMPRSS4
		Sirion Biotech Customized stable knockdown cell line services for TMPRSS4 Sirion Biotech Customized inducible knockdown cell line services for TMPRSS4 Sirion Biotech Customized stable overexpressing cell line services for TMPRSS4 Sirion Biotech Customized inducible overexpressing cell line services for TMPRSS4

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMPRSS4

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Measles

Influenza A

0.35

Pathway sources
See GeneCards unified pathways
Show all pathways

1 Kegg Pathway (Kegg details for TMPRSS4):

Influenza A

TMPRSS4 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for TMPRSS4

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006508	proteolysis	NAS	10825129

TMPRSS4 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TMPRSS4
Search CenterWatch for drugs/clinical trials and news about TMPRSS4 / TMPS4

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TMPRSS4 gene (5 alternative transcripts):

NM_001083947.1 NM_001173551.1 NM_001173552.1 NM_019894.3 NM_183247.1

Unigene Cluster for TMPRSS4:

Transmembrane protease, serine 4

Hs.161985 [show with all ESTs]

Unigene Representative Sequence: NM_019894

18 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000519126 ENST00000534111(uc021qrd.1 uc009yzu.3 uc021qre.1 uc010rxo.2 uc010rxs.2 uc010rxq.2 uc010rxr.2)

ENST00000519236 ENST00000522307 ENST00000523251 ENST00000517483 ENST00000437212(uc010rxt.2)

ENST00000522824 ENST00000522151 ENST00000520063 ENST00000522462 ENST00000517544

ENST00000519813 ENST00000528118 ENST00000518413 ENST00000518610 ENST00000524218

ENST00000523770

miRNA Products:		OriGene 3'-UTR Clone (see all 2): TMPRSS4 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TMPRSS4
		4 QIAGEN miScript miRNA Assays for microRNAs that regulate TMPRSS4:
		hsa-miR-345 hsa-miR-769-5p hsa-miR-2116 hsa-miR-4277
		SwitchGear 3'UTR luciferase reporter plasmid: TMPRSS4 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMPRSS4 (see all 7) OriGene shRNA RFP: TMPRSS4 OriGene siRNA: TMPRSS4
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMPRSS4
		Sirion Biotech Custom design and validation of potent shRNA sequences against TMPRSS4

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMPRSS4 (see all 7) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMPRSS4 (see all 5) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 4): TMPRSS4 (NM_019894)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMPRSS4
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMPRSS4

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMPRSS4 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat TMPRSS4
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMPRSS4
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMPRSS4

Additional cDNA sequence:

AF179224.1 AF216312.1 AK172766.1 AK290361.1 AK296855.1 AK303173.1 AK304113.1 AK304215.1

AK308434.1 AK311290.1 AY358530.1 BC011703.2 BC012752.2

12 DOTS entries:

DT.214418 DT.101982925 DT.70105294 DT.70104488 DT.99996946 DT.100785494 DT.91996667 DT.100000314

DT.120714941 DT.303382 DT.91718653 DT.91719449

24/166 AceView cDNA sequences (see all 166):

BM788163 BM830553 AW008897 AI380247 AA862082 BM763697 CB142529 BM788452

CA311909 AA481473 BM772620 BF939608 BU608684 CB159713 BM837092 BM772743

AI002848 BU157248 BM772754 BU676001 BM764659 AA906335 AA411502 AI478257

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for TMPRSS4 (see all 7) About this scheme

ExUns:	1	^	2	^	3a	·	3b	^	4a	·	4b	·	4c	^	5	^	6a	·	6b	^	7	^	8a	·	8b	^	9	^	10	^	11	^	12	^	13a	·	13b
SP1:									-
SP2:									-								-
SP3:									-																						-
SP4:									-		-		-
SP5:							-		-

ECgene alternative splicing isoforms for TMPRSS4

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TMPRSS4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGGTGGGCAT

About this image

TMPRSS4 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Gut Tube

Midgut

Midgut Endoderm Cells

Endoderm

Gut Tube

Midgut

Gut Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Human kidney epithelial cell spheroids (Kidney spheroids for...)

Genevestigator expression for TMPRSS4

SOURCE GeneReport for Unigene cluster: Hs.161985

UniProtKB/Swiss-Prot: TMPS4_HUMAN, Q9NRS4

Tissue specificity: High levels in pancreatic, gastric, colorectal and ampullary cancer. Very weak expression in normal

gastrointestinal and urogenital tract

SABiosciences Custom PCR Arrays for TMPRSS4

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMPRSS4 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat TMPRSS4
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMPRSS4
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMPRSS4

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMPRSS4

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for TMPRSS4 gene from 4/14 species (see all 14) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	TMPRSS4¹	transmembrane protease, serine 4	63.27(n) 54.86(a)		770454 XM_001233788.2 XP_001233789.2
lizard (Anolis carolinensis)	Reptilia	TMPRSS4⁶	--	44(a)	1 ↔ 1	GL343767.1(162598-171477)
zebrafish (Danio rerio)	Actinopterygii	tmprss4a¹	transmembrane protease, serine 4a	49.31(n) 41.61(a)		777630 NM_001077738.1 NP_001071206.1
fruit fly (Drosophila melanogaster)	Insecta	CG18065³ CG13430¹	CG13430¹	41(a) (best of 10)³ 48.51(n)¹ 43.3(a)¹		3772580¹ NM_001032270.1¹ NP_001027441.1¹

ENSEMBL Gene Tree for TMPRSS4 (if available)
TreeFam Gene Tree for TMPRSS4 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for TMPRSS4 gene

TMPRSS7² TMPRSS5² ST14² TMPRSS11D² TMPRSS13² TMPRSS11E² TMPRSS3² TMPRSS11B²

TMPRSS2² TMPRSS9² HPN² TMPRSS15² TMPRSS11F² TMPRSS11A² TMPRSS6²

18/81 SIMAP similar genes for TMPRSS4 using alignment to 8 protein entries: TMPS4_HUMAN (see all proteins) (see all similar genes):

DKFZp586F0824 TMPRSS11D PRSS1 CELA2B PRSS46 DKFZp779M0222

HP KLKB1 PROC1 TPSG1 PROC DESC1

PRSS21 PRSS41 TMPRSS11E TRY8 PRSS45 TMPRSS2

TMPRSS4 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs11216737^1,2	H	--	113879381(+)	`GCCCAG/AACAGC`	4	--	us2k¹		4		NS EA	420
rs78956504^1,2	C	--	113879722(+)	`AGGCCA/GCACTG`	4	--	us2k¹		2		WA	120
rs77548009^1,2	C	--	113880327(+)	`AGAACG/ATGAAT`	4	--	us2k¹		2		WA	120
rs3758998^1,2	C,F	--	113880589(+)	`AAGATC/AGCGCC`	4	--	us2k¹		4		NA	8
rs57723675^1,2		--	113880703(+)	`TACTCC/GAGAGG`	4	--	us2k¹		0	--	--	--	--
rs78100133^1,2	F	--	113880833(+)	`AAGAAA/GGAAAG`	4	--	us2k¹		1		NA	120
rs77390077^1,2	F	--	113881071(+)	`CACCTG/AGCAAT`	4	--	us2k¹		1		WA	118
rs60422720^1,2	C	--	113881196(+)	`GGGGAG/AGGGGG`	4	--	us2k¹		2		WA	120
rs17525348^1,2	F	--	113881251(+)	`GAAGTC/TATTCA`	4	--	us2k¹ tfbs³		3		EA MN	520
rs116802778^1,2	C,F	--	113881438(+)	`CCCCAA/GTCACT`	4	--	ut5¹		1		WA	118

HapMap Linkage Disequilibrium report for TMPRSS4 (117947727 - 117992605 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for TMPRSS4
1 CNV: 48706
Human Gene Mutation Database (HGMD): TMPRSS4

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMPRSS4

DNA2.0 Custom Variant and Variant Library Synthesis for TMPRSS4

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TMPRSS4 for disorders           About GeneDecksing

OMIM gene information: 606565    OMIM disorders: --

6 diseases for TMPRSS4:    About MalaCards

pancreatitis pancreatic carcinoma carcinoma hepatocellular carcinoma

influenza pancreatic cancer

1 disease from the University of Copenhagen DISEASES database for TMPRSS4:

Nonsyndromic deafness

Export disorders for TMPRSS4 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TMPRSS4 gene, integrated from 9 sources (see all 18):
(articles sorted by number of sources associating them with TMPRSS4)

Utopia: connect your pdf to the dynamic
world of online information

A novel transmembrane serine protease (TMPRSS3) overexpressed in pancreatic cancer. (PubMed id 10825129)^{1, 2, 3, 9} Wallrapp C.... Gress T.M. (2000)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2} Clark H.F.... Gray A.M. (2003)
Expression of TMPRSS4 in non-small cell lung cancer an d its modulation by hypoxia. (PubMed id 22692880)¹ Nguyen T.H....Shankara S. (2012)
Overexpression of TMPRSS4 in non-small cell lung canc er is associated with poor prognosis in patients with squamous histology. (PubMed id 22067904)¹ Larzabal L....Calvo A. (2011)
Radiation enhances long-term metastasis potential of residual hepatocellular carcinoma in nude mice through TMPRSS4-induced epitheli al-mesenchymal transition. (PubMed id 21637307)¹ Li T....Tang Z.Y. (2011)
TMPRSS4 induces invasion and epithelial-mesenchymal t ransition through upregulation of integrin alpha5 and its signaling pathways. (PubMed id 20118200)¹ Kim S....Park Y.K. (2010)
TMPRSS2 and TMPRSS4 facilitate trypsin-independent sp read of influenza virus in Caco-2 cells. (PubMed id 20631123)¹ Bertram S....PAPhlmann S. (2010)
Proteolytic activation of the 1918 influenza virus hemagglutinin. (PubMed id 19158246)¹ Chaipan C....PAPhlmann S. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 56649	HGNC: 11878	AceView: TMPRSS4	Ensembl:ENSG00000137648	euGenes: HUgn56649
ECgene: TMPRSS4	Kegg: 56649	H-InvDB: TMPRSS4

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for TMPRSS4	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for TMPRSS4	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for TMPRSS4 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for TMPRSS4 gene:
Search GeneIP for patents involving TMPRSS4

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	OriGene Antibodies for TMPRSS4		OriGene shRNA RFP for TMPRSS4
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMPRSS4		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMPRSS4
	OriGene Protein Over-expression Lysate for TMPRSS4		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for TMPRSS4		OriGene 3'-UTR Clone for TMPRSS4
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMPRSS4		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMPRSS4
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for TMPRSS4		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for TMPRSS4		OriGene Custom Protein Services for TMPRSS4
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TMPRSS4
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMPRSS4
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMPRSS4
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMPRSS4
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMPRSS4
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMPRSS4

	GenScript Custom Purified and Recombinant Proteins Services for TMPRSS4		GenScript cDNA clones with any tag delivered in your preferred vector for TMPRSS4
	GenScript Custom Assay Services for TMPRSS4		GenScript Custom Superior Antibodies Services for TMPRSS4
	GenScript Custom overexpressing Cell Line Services for TMPRSS4		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in TMPRSS4 promoter
	Search Chromatin IP Primers for TMPRSS4
	RT² qPCR Primer Assay in human, mouse, rat TMPRSS4
	Search GNC Networks for TMPRSS4
	SABiosciences Custom PCR Arrays for TMPRSS4

Search Tocris compounds for TMPRSS4

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	TMPRSS4 antibodies
	TMPRSS4 lysates

	Antibodies for TMPRSS4
	See all of Abcam's Antibodies, Kits and Proteins for TMPRSS4
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

TMPRSS4 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for TMPRSS4

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMPRSS4

	SwitchGear 3'UTR luciferase reporter plasmids for TMPRSS4
	SwitchGear Promoter luciferase reporter plasmids for TMPRSS4

ThermoFisher Antibodies for TMPRSS4

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMPRSS4

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for TMPRSS4

Sirion Biotech Customized:

	stable knockdown cell line services for TMPRSS4
	inducible knockdown cell line services for TMPRSS4
	design and validation of potent shRNA sequences against TMPRSS4
	adenovirus for potent knockdown of TMPRSS4
	adenovirus for overexpression of TMPRSS4
	stable overexpressing cell line services for TMPRSS4
	inducible overexpressing cell line services for TMPRSS4

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 13 May 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes TMPRSS4 gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4

Advanced Search

Export list of displayed genes

TMPRSS4 Gene

transmembrane protease, serine 4

Aliases
for TMPRSS4 gene

Summaries
for TMPRSS4 gene

Genomic Views
for TMPRSS4 gene

Proteins
for TMPRSS4 gene

Protein Domains /
Families
for TMPRSS4 gene

Function
for TMPRSS4 gene

Pathways & Interactions
for TMPRSS4 gene

Drugs & Compounds
for TMPRSS4 gene

Transcripts
for TMPRSS4 gene

Expression
for TMPRSS4 gene

Orthologs
for TMPRSS4 gene

Paralogs
for TMPRSS4 gene

Genomic Variants
for TMPRSS4 gene

Disorders / Diseases
for TMPRSS4 gene

Publications
for TMPRSS4 gene

External Searches for TMPRSS4 gene

Genome Databases showing TMPRSS4 gene

Other Databases showing TMPRSS4 gene

Specialized Databases showing TMPRSS4 gene

Intellectual Property
for TMPRSS4 gene

Products
for TMPRSS4 gene

View Random Gene

Advanced Search

Export list of displayed genes

TMPRSS4 Gene

transmembrane protease, serine 4

Aliasesfor TMPRSS4 gene

Summariesfor TMPRSS4 gene

Genomic Viewsfor TMPRSS4 gene

Proteinsfor TMPRSS4 gene

Protein Domains /Familiesfor TMPRSS4 gene

Functionfor TMPRSS4 gene

Pathways & Interactionsfor TMPRSS4 gene

Drugs & Compoundsfor TMPRSS4 gene

Transcriptsfor TMPRSS4 gene

Expression for TMPRSS4 gene

Orthologsfor TMPRSS4 gene

Paralogsfor TMPRSS4 gene

Genomic Variantsfor TMPRSS4 gene

Disorders / Diseasesfor TMPRSS4 gene

Publicationsfor TMPRSS4 gene

External Searches for TMPRSS4 gene

Genome Databases showing TMPRSS4 gene

Other Databases showing TMPRSS4 gene

Specialized Databases showing TMPRSS4 gene

Intellectual Propertyfor TMPRSS4 gene

Productsfor TMPRSS4 gene

View Random Gene

Aliases
for TMPRSS4 gene

Summaries
for TMPRSS4 gene

Genomic Views
for TMPRSS4 gene

Proteins
for TMPRSS4 gene

Protein Domains /
Families
for TMPRSS4 gene

Function
for TMPRSS4 gene

Pathways & Interactions
for TMPRSS4 gene

Drugs & Compounds
for TMPRSS4 gene

Transcripts
for TMPRSS4 gene

Expression
for TMPRSS4 gene

Orthologs
for TMPRSS4 gene

Paralogs
for TMPRSS4 gene

Genomic Variants
for TMPRSS4 gene

Disorders / Diseases
for TMPRSS4 gene

Publications
for TMPRSS4 gene

Intellectual Property
for TMPRSS4 gene

Products
for TMPRSS4 gene