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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TMPRSS4 Gene

protein-coding   GIFtS: 57
GCID: GC11P117981

Transmembrane Protease, Serine 4

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Transmembrane Protease, Serine 41 2     TMPRSS32 3
Membrane-Type Serine Protease 21 2 3     Transmembrane Protease Serine 42
Transmembrane Serine Protease 31 2     EC 3.4.21.-3
Type II Membrane Serine Protease1 2     EC 3.4.218
Channel-Activating Protease 22 3     EC 3.4.21.48
CAPH22 3     EC 3.4.21.438
MT-SP22 3     

External Ids:    HGNC: 118781   Entrez Gene: 566492   Ensembl: ENSG000001376487   OMIM: 6065655   UniProtKB: Q9NRS43   

Export aliases for TMPRSS4 gene to outside databases

Previous GC identifers: GC11P120304 GC11P119459 GC11P117485 GC11P117452 GC11P113881


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TMPRSS4 Gene:
This gene encodes a member of the serine protease family. Serine proteases are known to be involved in a variety
of biological processes, whose malfunction often leads to human diseases and disorders. This gene was identified
as a gene overexpressed in pancreatic carcinoma. The encoded protein is membrane bound with a N-terminal anchor
sequence and a glycosylated extracellular region containing the serine protease domain. Multiple transcript
variants encoding different isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for TMPRSS4 Gene: 
TMPRSS4 (transmembrane protease, serine 4) is a protein-coding gene. Diseases associated with TMPRSS4 include pancreatitis, and nonsyndromic deafness, and among its related super-pathways are Measles. GO annotations related to this gene include scavenger receptor activity and serine-type endopeptidase activity. An important paralog of this gene is TMPRSS11D.

UniProtKB/Swiss-Prot: TMPS4_HUMAN, Q9NRS4
Function: Probable protease. Seems to be capable of activating ENaC (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_033899.8  NC_018922.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TMPRSS4 gene promoter:
         GR   AML1a   Lmo2   POU3F2   C/EBPalpha   CHOP-10   CREB   deltaCREB   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMPRSS4 promoter sequence
   Search SABiosciences Chromatin IP Primers for TMPRSS4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMPRSS4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q23.3   Ensembl cytogenetic band:  11q23.3   HGNC cytogenetic band: 11q23.3

TMPRSS4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMPRSS4 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P117981:  view genomic region     (about GC identifiers)

Start:
117,947,727 bp from pter      End:
117,992,605 bp from pter
Size:
44,879 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TMPS4_HUMAN, Q9NRS4 (See protein sequence)
Recommended Name: Transmembrane protease serine 4  
Size: 437 amino acids; 48246 Da
Subcellular location: Membrane; Single-pass type II membrane protein (Potential)
Sequence caution: Sequence=AAF31436.1; Type=Frameshift; Positions=31;
Secondary accessions: A8MU84 B0YJB0 Q5XKQ6 Q6UX37 Q9NZA5
Alternative splicing: 3 isoforms:  Q9NRS4-1   Q9NRS4-2   Q9NRS4-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TMPRSS4: NX_Q9NRS4

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NRS4

  • 4/8 DME Specific Peptides for TMPRSS4 (Q9NRS4) (see all 8)
     GDSGGPL  PWQVSIQ  PGVYTKV  LTAAHCF 

    TMPRSS4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --
    REFSEQ proteins (4 alternative transcripts): 
    NP_001077416.1  NP_001167022.1  NP_001167023.1  NP_063947.1  

    ENSEMBL proteins: 
     ENSP00000435184   ENSP00000429889   ENSP00000428814   ENSP00000429209   ENSP00000431062  
     ENSP00000416037   ENSP00000430547   ENSP00000428407   ENSP00000429833   ENSP00000428246  

    Human Recombinant Protein Products for TMPRSS4: 
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TMPRSS4 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016020membrane ----
    GO:0016021integral to membrane NAS10825129

    TMPRSS4 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    TMPRSS: Serine peptidases / Transmembrane

    5/7 InterPro protein domains (see all 7):
     IPR002172 LDrepeatLR_classA_rpt
     IPR001314 Peptidase_S1A
     IPR001190 Srcr_rcpt
     IPR009003 Trypsin-like_Pept_dom
     IPR017448 Srcr_rcpt-rel

    Graphical View of Domain Structure for InterPro Entry Q9NRS4

    ProtoNet protein and cluster: Q9NRS4

    3 Blocks protein domains:
    IPB001254 Serine protease
    IPB001314 Chymotrypsin serine protease family (S1) signature
    IPB002172 Low density lipoprotein-receptor


    UniProtKB/Swiss-Prot: TMPS4_HUMAN, Q9NRS4
    Similarity: Belongs to the peptidase S1 family
    Similarity: Contains 1 LDL-receptor class A domain
    Similarity: Contains 1 peptidase S1 domain
    Similarity: Contains 1 SRCR domain


    TMPRSS4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TMPS4_HUMAN, Q9NRS4
    Function: Probable protease. Seems to be capable of activating ENaC (By similarity)

         Enzyme Numbers (IUBMB): EC 3.4.21.432 EC 3.4.21.42 EC 3.4.212 EC 3.4.21.-1

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004252serine-type endopeptidase activity NAS10825129
    GO:0005044scavenger receptor activity IEA--
    GO:0005515protein binding ----
         
    TMPRSS4 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI phenotypic allele for Tmprss4 (no phenotypes)

    TMPRSS4 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Tmprss4tm1Lex for TMPRSS4

       inGenious Targeting Laboratory - Custom generated mouse model solutions for TMPRSS4 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TMPRSS4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TMPRSS4 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TMPRSS4 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TMPRSS4
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate TMPRSS4:
    hsa-miR-345 hsa-miR-769-5p hsa-miR-2116 hsa-miR-4277
    SwitchGear 3'UTR luciferase reporter plasmidTMPRSS4 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMPRSS4


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TMPRSS4 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Influenza A
    Influenza A0.34

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    1         Kegg Pathway  (Kegg details for TMPRSS4):
        Influenza A


    TMPRSS4 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMPRSS4

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis NAS10825129

    TMPRSS4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TMPRSS4 (TMPS4)

    Search CenterWatch for drugs/clinical trials and news about TMPRSS4 / TMPS4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TMPRSS4 gene (5 alternative transcripts): 
    NM_001083947.1  NM_001173551.1  NM_001173552.1  NM_019894.3  NM_183247.1  

    Unigene Cluster for TMPRSS4:

    Transmembrane protease, serine 4
    Hs.161985  [show with all ESTs]
    Unigene Representative Sequence: NM_019894
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000519126 ENST00000534111(uc021qrd.1 uc009yzu.3 uc021qre.1 uc010rxo.2 uc010rxs.2 uc010rxq.2 uc010rxr.2)
    ENST00000519236 ENST00000522307 ENST00000523251 ENST00000517483 ENST00000437212(uc010rxt.2)
    ENST00000522824 ENST00000522151 ENST00000520063 ENST00000522462 ENST00000517544
    ENST00000519813 ENST00000528118 ENST00000518413 ENST00000518610 ENST00000524218
    ENST00000523770
    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TMPRSS4
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate TMPRSS4:
    hsa-miR-345 hsa-miR-769-5p hsa-miR-2116 hsa-miR-4277
    SwitchGear 3'UTR luciferase reporter plasmidTMPRSS4 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMPRSS4
    Sirion Biotech Customized lentivirus for stable overexpression of TMPRSS4 
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMPRSS4
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    Additional mRNA sequence: 

    AF179224.1 AF216312.1 AK172766.1 AK290361.1 AK296855.1 AK303173.1 AK304113.1 AK304215.1 
    AK308434.1 AK311290.1 AY358530.1 BC011703.2 BC012752.2 

    12 DOTS entries:

    DT.214418  DT.101982925  DT.70105294  DT.70104488  DT.99996946  DT.100785494  DT.91996667  DT.100000314 
    DT.120714941  DT.303382  DT.91718653  DT.91719449 

    24/166 AceView cDNA sequences (see all 166):

    BM763697 AW008897 AI380247 BM830553 BM788163 BU157248 CB159713 BM772754 
    BM837092 BM772743 CA311909 BM788452 AI002848 AA481473 BM772620 BF939608 
    BU608684 BM773306 D31382 AW000937 BU676001 AA906335 BM764659 AA411502 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for TMPRSS4 (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b
    SP1:                          -                                                                                       
    SP2:                          -                       -                                                               
    SP3:                          -                                                                 -                     
    SP4:                          -     -     -                                                                           
    SP5:                    -     -                                                                                       


    ECgene alternative splicing isoforms for TMPRSS4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TMPRSS4 expression in normal human tissues (normalized intensities)      TMPRSS4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGTGGGCAT
    TMPRSS4 Expression
    About this image


    TMPRSS4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 3 entries
             Hindgut
     
     Nose (Sensory Organs)
             sensory organ/nose/nasal cavity   
     
     Oral Cavity (Gastrointestinal Tract)
             TONGUE   
     
     Colon (Gastrointestinal Tract)
     
     Esophagus (Gastrointestinal Tract)

    Genevestigator expression for TMPRSS4

    SOURCE GeneReport for Unigene cluster: Hs.161985

    UniProtKB/Swiss-Prot: TMPS4_HUMAN, Q9NRS4
    Tissue specificity: High levels in pancreatic, gastric, colorectal and ampullary cancer. Very weak expression in
    normal gastrointestinal and urogenital tract

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMPRSS4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TMPRSS4 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tmprss41 , 5 transmembrane protease, serine 41, 5 81.61(n)1
    77.24(a)1
      9 (24.84 cM)5
    2145231  NM_145403.21  NP_663378.11 
     451727265 
    chicken
    (Gallus gallus)
    Aves TMPRSS41 transmembrane protease, serine 4 63.27(n)
    54.86(a)
      770454  XM_001233788.2  XP_001233789.2 
    lizard
    (Anolis carolinensis)
    Reptilia TMPRSS46
    Uncharacterized protein
    47(a)
    1 ↔ 1
    GL343767.1(162598-171477)
    zebrafish
    (Danio rerio)
    Actinopterygii tmprss4a1 transmembrane protease, serine 4a 49.31(n)
    41.61(a)
      777630  NM_001077738.1  NP_001071206.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG180653
    CG134301
    CG134301 41(a)
    (best of 10)3
    48.51(n)1
    43.3(a)1
      37725801  NM_001032270.11  NP_001027441.11 
    worm
    (Caenorhabditis elegans)
    Secernentea try-16
    Protein TRY-1
    30(a)
    1 → many
    II(4948154-4949486)


    ENSEMBL Gene Tree for TMPRSS4 (if available)
    TreeFam Gene Tree for TMPRSS4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TMPRSS4 gene
    TMPRSS11D2  TMPRSS32  TMPRSS11B2  TMPRSS62  TMPRSS11A2  TMPRSS72  TMPRSS52  ST142  
    TMPRSS132  TMPRSS11E2  KLKB12  TMPRSS22  F112  HPN2  TMPRSS152  TMPRSS11F2  
    18/77 SIMAP similar genes for TMPRSS4 using alignment to 8 protein entries:     TMPS4_HUMAN (see all proteins) (see all similar genes):
    DKFZp586F0824    TMPRSS11D    PRSS1    CELA2B    PRSS46    DKFZp779M0222
    HP    KLKB1    PROC1    TPSG1    PROC    DESC1
    PRSS21    PRSS41    TMPRSS11E    TRY8    PRSS45    TMPRSS2

    TMPRSS4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1175 SNPs in TMPRSS4 are shown (see all 1175)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0465064
    ----see VAR_0465062 V G mis40--------
    rs349979881,2
    C--113892753(+) TTCCTG/-CTGCC 4 -- int11Minor allele frequency- -:0.50NA 2
    rs340558511,2
    C--113896069(+) CCCAT-/CCTGGT 4 -- int12Minor allele frequency- C:0.25NA 4
    rs562221601,2
    C--113898183(+) CCCCC-/C/CC  
            
    AATGG
    4 -- int11NA 2
    rs122231101,2
    F--113901188(+) gaaagG/Aaagaa 4 -- int1 trp33Minor allele frequency- A:0.50NA 6
    rs122259361,2
    C--113901194(+) aagaaA/Ggaaag 4 -- int1 trp32Minor allele frequency- G:0.17NA 6
    rs112167411,2
    F,A--113901200(+) GAAAGA/GAGGAA 4 -- int1 trp32Minor allele frequency- G:0.33NA 6
    rs108922131,2
    C--113901202(+) AAGAAA/GGAAAG 4 -- int1 trp32Minor allele frequency- G:0.17NA 6
    rs122231151,2
    A--113901249(+) aaagaA/Gagaaa 4 -- int10--------
    rs612487651,2
    C--113901259(+) AGAAA-/AG/G  
            
    GAAAG
    4 -- int10--------

    HapMap Linkage Disequilibrium report for TMPRSS4 (117947727 - 117992605 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for TMPRSS4:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2745122CNV Deletion23290073
    nsv509444CNV Insertion20534489
    nsv515768CNV Loss19592680
    esv275347CNV Loss21479260
    dgv1318n71CNV Gain21882294
    nsv468878CNV Gain19166990


    Human Gene Mutation Database (HGMD): TMPRSS4
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606565    OMIM disorders: --

    7 diseases for TMPRSS4:    About MalaCards
    pancreatitis    nonsyndromic deafness    influenza    pancreatic cancer
    hepatocellular carcinoma    hypoxia    lung cancer

    1 disease from the University of Copenhagen DISEASES database for TMPRSS4:
    Nonsyndromic deafness

    TMPRSS4 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TMPRSS4

    Export disorders for TMPRSS4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TMPRSS4 gene, integrated from 9 sources (see all 19):
    (articles sorted by number of sources associating them with TMPRSS4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel transmembrane serine protease (TMPRSS3) overexpressed in pancreatic cancer. (PubMed id 10825129)1, 2, 3, 9 Wallrapp C.... Gress T.M. (2000)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    5. Expression of TMPRSS4 in non-small cell lung cancer an d its modulation by hypoxia. (PubMed id 22692880)1 Nguyen T.H....Shankara S. (2012)
    6. TMPRSS4 is a type II transmembrane serine protease inv olved in cancer and viral infections. (PubMed id 22944691)1 Ohler A. and Becker-Pauly C. (2012)
    7. Overexpression of TMPRSS4 in non-small cell lung canc er is associated with poor prognosis in patients with squamous histology. (PubMed id 22067904)1 Larzabal L....Calvo A. (2011)
    8. Radiation enhances long-term metastasis potential of residual hepatocellular carcinoma in nude mice through TMPRSS4-induced epitheli al-mesenchymal transition. (PubMed id 21637307)1 Li T....Tang Z.Y. (2011)
    9. TMPRSS4 induces invasion and epithelial-mesenchymal t ransition through upregulation of integrin alpha5 and its signaling pathways. (PubMed id 20118200)1 Kim S....Park Y.K. (2010)
    10. TMPRSS2 and TMPRSS4 facilitate trypsin-independent sp read of influenza virus in Caco-2 cells. (PubMed id 20631123)1 Bertram S....PAPhlmann S. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 56649 HGNC: 11878 AceView: TMPRSS4 Ensembl:ENSG00000137648 euGenes: HUgn56649
    ECgene: TMPRSS4 Kegg: 56649 H-InvDB: TMPRSS4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TMPRSS4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TMPRSS4 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TMPRSS4 gene:
    Search GeneIP for patents involving TMPRSS4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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