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Aliases for TMPRSS4 Gene

Aliases for TMPRSS4 Gene

  • Transmembrane Protease, Serine 4 2 3 5
  • Membrane-Type Serine Protease 2 2 3 4
  • Type II Membrane Serine Protease 2 3
  • Transmembrane Serine Protease 3 2 3
  • Channel-Activating Protease 2 3 4
  • TMPRSS3 3 4
  • MT-SP2 3 4
  • CAPH2 3 4
  • EC 63
  • EC 63
  • EC 3.4.21.- 4
  • EC 3.4.21 63

External Ids for TMPRSS4 Gene

Previous GeneCards Identifiers for TMPRSS4 Gene

  • GC11P120304
  • GC11P119459
  • GC11P117981
  • GC11P117485
  • GC11P117452
  • GC11P113881
  • GC11P117949

Summaries for TMPRSS4 Gene

Entrez Gene Summary for TMPRSS4 Gene

  • This gene encodes a member of the serine protease family. Serine proteases are known to be involved in a variety of biological processes, whose malfunction often leads to human diseases and disorders. This gene was identified as a gene overexpressed in pancreatic carcinoma. The encoded protein is membrane bound with a N-terminal anchor sequence and a glycosylated extracellular region containing the serine protease domain. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for TMPRSS4 Gene

TMPRSS4 (Transmembrane Protease, Serine 4) is a Protein Coding gene. Diseases associated with TMPRSS4 include Autosomal Recessive Cerebral Atrophy. Among its related pathways are Influenza A. GO annotations related to this gene include serine-type endopeptidase activity and scavenger receptor activity. An important paralog of this gene is TMPRSS11A.

UniProtKB/Swiss-Prot for TMPRSS4 Gene

  • Probable protease. Seems to be capable of activating ENaC (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMPRSS4 Gene

Genomics for TMPRSS4 Gene

Regulatory Elements for TMPRSS4 Gene

Enhancers for TMPRSS4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TMPRSS4 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMPRSS4 Gene

118,077,012 bp from pter
118,125,505 bp from pter
48,494 bases
Plus strand

Genomic View for TMPRSS4 Gene

Genes around TMPRSS4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMPRSS4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMPRSS4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMPRSS4 Gene

Proteins for TMPRSS4 Gene

  • Protein details for TMPRSS4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protease serine 4
    Protein Accession:
    Secondary Accessions:
    • A8MU84
    • B0YJB0
    • B7Z8C5
    • E7ERX8
    • Q5XKQ6
    • Q6UX37
    • Q9NZA5

    Protein attributes for TMPRSS4 Gene

    437 amino acids
    Molecular mass:
    48246 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAF31436.1; Type=Frameshift; Positions=31; Evidence={ECO:0000305};

    Alternative splice isoforms for TMPRSS4 Gene


neXtProt entry for TMPRSS4 Gene

Proteomics data for TMPRSS4 Gene at MOPED

Selected DME Specific Peptides for TMPRSS4 Gene

Post-translational modifications for TMPRSS4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for TMPRSS4 Gene

Gene Families for TMPRSS4 Gene

Suggested Antigen Peptide Sequences for TMPRSS4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 LDL-receptor class A domain.
  • Belongs to the peptidase S1 family.
  • Contains 1 LDL-receptor class A domain.
  • Contains 1 peptidase S1 domain.
  • Contains 1 SRCR domain.
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with TMPRSS4: view

Function for TMPRSS4 Gene

Molecular function for TMPRSS4 Gene

UniProtKB/Swiss-Prot Function:
Probable protease. Seems to be capable of activating ENaC (By similarity).

Enzyme Numbers (IUBMB) for TMPRSS4 Gene

genes like me logo Genes that share phenotypes with TMPRSS4: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TMPRSS4

CRISPR Products

Flow Cytometry Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMPRSS4 Gene

Localization for TMPRSS4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMPRSS4 Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

Jensen Localization Image for TMPRSS4 Gene COMPARTMENTS Subcellular localization image for TMPRSS4 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for TMPRSS4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA,NAS 10825129
genes like me logo Genes that share ontologies with TMPRSS4: view

Pathways & Interactions for TMPRSS4 Gene

SuperPathways for TMPRSS4 Gene

Superpath Contained pathways
1 Influenza A
genes like me logo Genes that share pathways with TMPRSS4: view

Pathways by source for TMPRSS4 Gene

1 KEGG pathway for TMPRSS4 Gene

Gene Ontology (GO) - Biological Process for TMPRSS4 Gene


No data available for SIGNOR curated interactions for TMPRSS4 Gene

Drugs & Compounds for TMPRSS4 Gene

(1) Drugs for TMPRSS4 Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
PMSF Pharma Serine proteinases inhibitor, irreversible 0

(1) ApexBio Compounds for TMPRSS4 Gene

Compound Action Cas Number
PMSF Serine proteinases inhibitor, irreversible 329-98-6
genes like me logo Genes that share compounds with TMPRSS4: view

Transcripts for TMPRSS4 Gene

Unigene Clusters for TMPRSS4 Gene

Transmembrane protease, serine 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMPRSS4 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b
SP1: -
SP2: - -
SP3: - -
SP4: - - -
SP5: - -
SP7: - -

Relevant External Links for TMPRSS4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMPRSS4 Gene

mRNA expression in normal human tissues for TMPRSS4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMPRSS4 Gene

This gene is overexpressed in Esophagus - Mucosa (x16.7), Colon - Transverse (x11.5), and Bladder (x7.2).

Protein differential expression in normal tissues from HIPED for TMPRSS4 Gene

This gene is overexpressed in Rectum (37.5) and Colon (31.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TMPRSS4 Gene

SOURCE GeneReport for Unigene cluster for TMPRSS4 Gene Hs.161985

mRNA Expression by UniProt/SwissProt for TMPRSS4 Gene

Tissue specificity: High levels in pancreatic, gastric, colorectal and ampullary cancer. Very weak expression in normal gastrointestinal and urogenital tract.
genes like me logo Genes that share expression patterns with TMPRSS4: view

Protein tissue co-expression partners for TMPRSS4 Gene

Primer Products

Orthologs for TMPRSS4 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMPRSS4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TMPRSS4 35
  • 84.56 (n)
  • 77.65 (a)
  • 76 (a)
(Canis familiaris)
Mammalia TMPRSS4 35
  • 86.99 (n)
  • 83.14 (a)
  • 81 (a)
(Mus musculus)
Mammalia Tmprss4 35
  • 81.61 (n)
  • 77.24 (a)
Tmprss4 16
Tmprss4 36
  • 77 (a)
(Pan troglodytes)
Mammalia TMPRSS4 35
  • 99.23 (n)
  • 99.08 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Tmprss4 35
  • 80.84 (n)
  • 74.71 (a)
(Monodelphis domestica)
Mammalia TMPRSS4 36
  • 51 (a)
(Ornithorhynchus anatinus)
Mammalia TMPRSS4 36
  • 61 (a)
(Gallus gallus)
Aves TMPRSS4 35
  • 63.19 (n)
  • 54.4 (a)
  • 53 (a)
(Anolis carolinensis)
Reptilia TMPRSS4 36
  • 47 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tmprss4 35
  • 50.87 (n)
  • 43.64 (a)
(Danio rerio)
Actinopterygii tmprss4a 35
  • 49.31 (n)
  • 41.61 (a)
tmprss4a 36
  • 36 (a)
tmprss4b 36
  • 33 (a)
fruit fly
(Drosophila melanogaster)
Insecta BEST:GH02921 37
  • 35 (a)
CG10405 37
  • 36 (a)
CG11192 37
  • 37 (a)
CG18065 37
  • 41 (a)
CG4613 37
  • 37 (a)
CG4914 37
  • 36 (a)
CG6865 37
  • 33 (a)
CG9372 37
  • 37 (a)
lgrTry 37
  • 38 (a)
Try29F 37
  • 38 (a)
lambdaTry 35
  • 47.06 (n)
  • 40.34 (a)
Species with no ortholog for TMPRSS4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMPRSS4 Gene

Gene Tree for TMPRSS4 (if available)
Gene Tree for TMPRSS4 (if available)

Paralogs for TMPRSS4 Gene

genes like me logo Genes that share paralogs with TMPRSS4: view

Variants for TMPRSS4 Gene

Sequence variations from dbSNP and Humsavar for TMPRSS4 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1894176 - 118,107,863(-) AGTTC(C/T)GCATG nc-transcript-variant, reference, missense
rs12270001 - 118,111,749(+) GTGGG(A/G)AGAGC nc-transcript-variant, reference, missense
rs1941635 - 118,111,780(+) GGGTG(G/T)GGAGG nc-transcript-variant, reference, missense
rs592009 -- 118,116,413(+) AGGGG(G/T)GCATT intron-variant
rs596134 -- 118,113,908(+) TTATA(C/T)TGAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMPRSS4 Gene

Variant ID Type Subtype PubMed ID
nsv509444 CNV Insertion 20534489
dgv1318n71 CNV Gain 21882294
nsv468878 CNV Gain 19166990
nsv515768 CNV Loss 19592680
esv2745122 CNV Deletion 23290073
esv275347 CNV Loss 21479260

Variation tolerance for TMPRSS4 Gene

Residual Variation Intolerance Score: 54% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.43; 88.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMPRSS4 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMPRSS4 Gene

Disorders for TMPRSS4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TMPRSS4 Gene - From: Orphanet

Disorder Aliases PubMed IDs
autosomal recessive cerebral atrophy
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TMPRSS4

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TMPRSS4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TMPRSS4 Gene

Publications for TMPRSS4 Gene

  1. A novel transmembrane serine protease (TMPRSS3) overexpressed in pancreatic cancer. (PMID: 10825129) Wallrapp C. … Gress T.M. (Cancer Res. 2000) 2 3 4 23 67
  2. TMPRSS4: an emerging potential therapeutic target in cancer. (PMID: 25203520) de Aberasturi A.L. … Calvo A. (Br. J. Cancer 2015) 3
  3. Transmembrane protease serine 4 promotes thyroid cancer proliferation via CREB phosphorylation. (PMID: 25244400) Guan H. … Li Y. (Thyroid 2015) 3
  4. Methylation-induced downregulation of TFPI-2 causes TMPRSS4 overexpression and contributes to oncogenesis in a subset of non-small-cell lung carcinoma. (PMID: 25414083) Hamamoto J. … Betsuyaku T. (Cancer Sci. 2015) 3
  5. TMPRSS4 upregulates uPA gene expression through JNK signaling activation to induce cancer cell invasion. (PMID: 23978400) Min H.J. … Kim S. (Cell. Signal. 2014) 3

Products for TMPRSS4 Gene

Sources for TMPRSS4 Gene