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Aliases for TMPRSS4 Gene

Aliases for TMPRSS4 Gene

  • Membrane-Type Serine Protease 2 2 3 4
  • Type II Membrane Serine Protease 2 3
  • Transmembrane Protease, Serine 4 2 3
  • Transmembrane Serine Protease 3 2 3
  • Channel-Activating Protease 2 3 4
  • TMPRSS3 3 4
  • MT-SP2 3 4
  • CAPH2 3 4
  • Transmembrane Protease Serine 4 3
  • EC 63
  • EC 63
  • EC 3.4.21.- 4
  • EC 3.4.21 63

External Ids for TMPRSS4 Gene

Previous GeneCards Identifiers for TMPRSS4 Gene

  • GC11P120304
  • GC11P119459
  • GC11P117981
  • GC11P117485
  • GC11P117452
  • GC11P113881
  • GC11P117949

Summaries for TMPRSS4 Gene

Entrez Gene Summary for TMPRSS4 Gene

  • This gene encodes a member of the serine protease family. Serine proteases are known to be involved in a variety of biological processes, whose malfunction often leads to human diseases and disorders. This gene was identified as a gene overexpressed in pancreatic carcinoma. The encoded protein is membrane bound with a N-terminal anchor sequence and a glycosylated extracellular region containing the serine protease domain. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for TMPRSS4 Gene

TMPRSS4 is a Protein Coding gene. Diseases associated with TMPRSS4 include autosomal recessive cerebral atrophy. Among its related pathways are Influenza A. GO annotations related to this gene include serine-type endopeptidase activity and scavenger receptor activity. An important paralog of this gene is HPN.

UniProtKB/Swiss-Prot for TMPRSS4 Gene

  • Probable protease. Seems to be capable of activating ENaC (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMPRSS4 Gene

Genomics for TMPRSS4 Gene

Regulatory Elements for TMPRSS4 Gene

Genomic Location for TMPRSS4 Gene

118,077,012 bp from pter
118,125,608 bp from pter
48,597 bases
Plus strand

Genomic View for TMPRSS4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMPRSS4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMPRSS4 Gene

Proteins for TMPRSS4 Gene

  • Protein details for TMPRSS4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protease serine 4
    Protein Accession:
    Secondary Accessions:
    • A8MU84
    • B0YJB0
    • B7Z8C5
    • E7ERX8
    • Q5XKQ6
    • Q6UX37
    • Q9NZA5

    Protein attributes for TMPRSS4 Gene

    437 amino acids
    Molecular mass:
    48246 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAF31436.1; Type=Frameshift; Positions=31; Evidence={ECO:0000305};

    Alternative splice isoforms for TMPRSS4 Gene


neXtProt entry for TMPRSS4 Gene

Proteomics data for TMPRSS4 Gene at MOPED

Selected DME Specific Peptides for TMPRSS4 Gene

Post-translational modifications for TMPRSS4 Gene

  • Glycosylation at Asn130 and Asn178
  • Modification sites at PhosphoSitePlus

Antibody Products

Domains for TMPRSS4 Gene

Gene Families for TMPRSS4 Gene

  • TMPRSS :Serine peptidases / Transmembrane

Suggested Antigen Peptide Sequences for TMPRSS4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9NRS4
  • Contains 1 LDL-receptor class A domain.
  • Contains 1 peptidase S1 domain.
  • Contains 1 SRCR domain.
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with TMPRSS4: view

Function for TMPRSS4 Gene

Molecular function for TMPRSS4 Gene

UniProtKB/Swiss-Prot Function:
Probable protease. Seems to be capable of activating ENaC (By similarity).

Enzyme Numbers (IUBMB) for TMPRSS4 Gene

Gene Ontology (GO) - Molecular Function for TMPRSS4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004252 serine-type endopeptidase activity NAS 10825129
GO:0005044 scavenger receptor activity IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TMPRSS4: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMPRSS4

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TMPRSS4 Gene

Localization for TMPRSS4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMPRSS4 Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

Jensen Localization Image for TMPRSS4 Gene COMPARTMENTS Subcellular localization image for TMPRSS4 gene
Compartment Confidence
plasma membrane 3
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for TMPRSS4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane --
GO:0016021 integral component of membrane NAS 10825129
genes like me logo Genes that share ontologies with TMPRSS4: view

Pathways for TMPRSS4 Gene

SuperPathways for TMPRSS4 Gene

Superpath Contained pathways
1 Influenza A
genes like me logo Genes that share pathways with TMPRSS4: view

Pathways by source for TMPRSS4 Gene

1 KEGG pathway for TMPRSS4 Gene

Gene Ontology (GO) - Biological Process for TMPRSS4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis NAS 10825129
GO:0006898 receptor-mediated endocytosis IEA --
GO:0008152 metabolic process --
genes like me logo Genes that share ontologies with TMPRSS4: view

Compounds for TMPRSS4 Gene

(1) ApexBio Compounds for TMPRSS4 Gene

Compound Action Cas Number
PMSF "Serine proteinases inhibitor, irreversible" [329-98-6]
genes like me logo Genes that share compounds with TMPRSS4: view

Transcripts for TMPRSS4 Gene

Unigene Clusters for TMPRSS4 Gene

Transmembrane protease, serine 4:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMPRSS4

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMPRSS4 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b
SP1: -
SP2: - -
SP3: - -
SP4: - - -
SP5: - -
SP7: - -

Relevant External Links for TMPRSS4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMPRSS4 Gene

mRNA expression in normal human tissues for TMPRSS4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMPRSS4 Gene

This gene is overexpressed in Esophagus - Mucosa (16.7), Colon - Transverse (11.5), and Bladder (7.2).

Protein differential expression in normal tissues for TMPRSS4 Gene

This gene is overexpressed in Rectum (37.5) and Colon (31.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TMPRSS4 Gene

SOURCE GeneReport for Unigene cluster for TMPRSS4 Gene Hs.161985

mRNA Expression by UniProt/SwissProt for TMPRSS4 Gene

Tissue specificity: High levels in pancreatic, gastric, colorectal and ampullary cancer. Very weak expression in normal gastrointestinal and urogenital tract
genes like me logo Genes that share expressions with TMPRSS4: view

Expression partners for TMPRSS4 Gene

In Situ Assay Products

Orthologs for TMPRSS4 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMPRSS4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TMPRSS4 35
  • 84.56 (n)
  • 77.65 (a)
  • 76 (a)
(Canis familiaris)
Mammalia TMPRSS4 35
  • 86.99 (n)
  • 83.14 (a)
  • 81 (a)
(Mus musculus)
Mammalia Tmprss4 35
  • 81.61 (n)
  • 77.24 (a)
Tmprss4 16
Tmprss4 36
  • 77 (a)
(Pan troglodytes)
Mammalia TMPRSS4 35
  • 99.23 (n)
  • 99.08 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Tmprss4 35
  • 80.84 (n)
  • 74.71 (a)
(Monodelphis domestica)
Mammalia TMPRSS4 36
  • 51 (a)
(Ornithorhynchus anatinus)
Mammalia TMPRSS4 36
  • 61 (a)
(Gallus gallus)
Aves TMPRSS4 35
  • 63.19 (n)
  • 54.4 (a)
  • 53 (a)
(Anolis carolinensis)
Reptilia TMPRSS4 36
  • 47 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tmprss4 35
  • 50.87 (n)
  • 43.64 (a)
(Danio rerio)
Actinopterygii tmprss4a 35
  • 49.31 (n)
  • 41.61 (a)
tmprss4a 36
  • 36 (a)
tmprss4b 36
  • 33 (a)
fruit fly
(Drosophila melanogaster)
Insecta BEST:GH02921 37
  • 35 (a)
CG10405 37
  • 36 (a)
CG11192 37
  • 37 (a)
CG18065 37
  • 41 (a)
CG4613 37
  • 37 (a)
CG4914 37
  • 36 (a)
CG6865 37
  • 33 (a)
CG9372 37
  • 37 (a)
lgrTry 37
  • 38 (a)
Try29F 37
  • 38 (a)
lambdaTry 35
  • 47.06 (n)
  • 40.34 (a)
Species with no ortholog for TMPRSS4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMPRSS4 Gene

Gene Tree for TMPRSS4 (if available)
Gene Tree for TMPRSS4 (if available)

Paralogs for TMPRSS4 Gene

genes like me logo Genes that share paralogs with TMPRSS4: view

Variants for TMPRSS4 Gene

Sequence variations from dbSNP and Humsavar for TMPRSS4 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs8924 -- 118,118,069(+) TTCCT(A/G)TAAGA utr-variant-3-prime, nc-transcript-variant, intron-variant
rs592009 -- 118,116,413(+) AGGGG(G/T)GCATT intron-variant
rs596134 -- 118,113,908(+) TTATA(C/T)TGAAA intron-variant
rs598061 -- 118,114,365(-) tgttg(G/T)ggggt intron-variant
rs599343 -- 118,123,715(+) GAGAC(A/G)GGGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMPRSS4 Gene

Variant ID Type Subtype PubMed ID
nsv509444 CNV Insertion 20534489
dgv1318n71 CNV Gain 21882294
nsv468878 CNV Gain 19166990
nsv515768 CNV Loss 19592680
esv2745122 CNV Deletion 23290073
esv275347 CNV Loss 21479260

Relevant External Links for TMPRSS4 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMPRSS4 Gene

Disorders for TMPRSS4 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for TMPRSS4 Gene in MalaCards »

(1) Diseases for TMPRSS4 Gene including...

(1) University of Copenhagen DISEASES for TMPRSS4 Gene

Relevant External Links for TMPRSS4

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with TMPRSS4: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for TMPRSS4 Gene

Publications for TMPRSS4 Gene

  1. A novel transmembrane serine protease (TMPRSS3) overexpressed in pancreatic cancer. (PMID: 10825129) Wallrapp C. … Gress T.M. (Cancer Res. 2000) 2 3 4 23
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3

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