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Aliases for TMPRSS2 Gene

Aliases for TMPRSS2 Gene

  • Transmembrane Protease, Serine 2 2 3
  • Serine Protease 10 3 4
  • PRSS10 3 4
  • Transmembrane Protease Serine 2 3
  • EC 3.4.21.109 63
  • Epitheliasin 3
  • EC 3.4.21.- 4
  • EC 3.4.21 63
  • PP9284 3

External Ids for TMPRSS2 Gene

Previous GeneCards Identifiers for TMPRSS2 Gene

  • GC21M039410
  • GC21M041757
  • GC21M041756
  • GC21M041750
  • GC21M042836
  • GC21M028305

Summaries for TMPRSS2 Gene

Entrez Gene Summary for TMPRSS2 Gene

  • This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Serine proteases are known to be involved in many physiological and pathological processes. This gene was demonstrated to be up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate cancer tissue. The protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]

GeneCards Summary for TMPRSS2 Gene

TMPRSS2 is a Protein Coding gene. Diseases associated with TMPRSS2 include prostate cancer. Among its related pathways are Transcriptional misregulation in cancer and Regulation of Androgen receptor activity. GO annotations related to this gene include serine-type endopeptidase activity and scavenger receptor activity. An important paralog of this gene is HPN.

UniProtKB/Swiss-Prot for TMPRSS2 Gene

  • Serine protease that proteolytically cleaves and activates the viral spike glycoproteins which facilitate virus-cell membrane fusions; spike proteins are synthesized and maintained in precursor intermediate folding states and proteolysis permits the refolding and energy release required to create stable virus-cell linkages and membrane coalescence. Facilitates human SARS coronavirus (SARS-CoV) infection via two independent mechanisms, proteolytic cleavage of ACE2, which might promote viral uptake, and cleavage of coronavirus spike glycoprotein which activates the glycoprotein for cathepsin L-independent host cell entry. Proteolytically cleaves and activates the spike glycoproteins of human coronavirus 229E (HCoV-229E) and human coronavirus EMC (HCoV-EMC) and the fusion glycoproteins F0 of Sendai virus (SeV), human metapneumovirus (HMPV), human parainfluenza 1, 2, 3, 4a and 4b viruses (HPIV). Essential for spread and pathogenesis of influenza A virus (strains H1N1, H3N2 and H7N9); involved in proteolytic cleavage and activation of hemagglutinin (HA) protein which is essential for viral infectivity.

Gene Wiki entry for TMPRSS2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMPRSS2 Gene

Genomics for TMPRSS2 Gene

Regulatory Elements for TMPRSS2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TMPRSS2 Gene

Start:
41,464,309 bp from pter
End:
41,531,116 bp from pter
Size:
66,808 bases
Orientation:
Minus strand

Genomic View for TMPRSS2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMPRSS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMPRSS2 Gene

Proteins for TMPRSS2 Gene

  • Protein details for TMPRSS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15393-TMPS2_HUMAN
    Recommended name:
    Transmembrane protease serine 2
    Protein Accession:
    O15393
    Secondary Accessions:
    • A8K6Z8
    • B2R8E5
    • B7Z459
    • D3DSJ2
    • F8WES1
    • Q6GTK7
    • Q9BXX1

    Protein attributes for TMPRSS2 Gene

    Size:
    492 amino acids
    Molecular mass:
    53859 Da
    Quaternary structure:
    • The catalytically active form interacts with ACE2.

    Alternative splice isoforms for TMPRSS2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMPRSS2 Gene

Proteomics data for TMPRSS2 Gene at MOPED

Selected DME Specific Peptides for TMPRSS2 Gene

Post-translational modifications for TMPRSS2 Gene

  • Proteolytically processed; by an autocatalytic mechanism
  • Glycosylation at Asn213 and Asn249
  • Modification sites at PhosphoSitePlus

Other Protein References for TMPRSS2 Gene

Domains for TMPRSS2 Gene

Gene Families for TMPRSS2 Gene

HGNC:
  • TMPRSS :Serine peptidases / Transmembrane

Suggested Antigen Peptide Sequences for TMPRSS2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O15393

UniProtKB/Swiss-Prot:

TMPS2_HUMAN :
  • O15393
Domain:
  • Contains 1 LDL-receptor class A domain.
  • Contains 1 peptidase S1 domain.
  • Contains 1 SRCR domain.
Family:
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with TMPRSS2: view

Function for TMPRSS2 Gene

Molecular function for TMPRSS2 Gene

GENATLAS Biochemistry: transmembrane protein,type II,strongly expressed in small intestine and in normal or carcinoid cells of epithelial prostate,homologous to the enteropeptidase gene,potentially involved in prostate carcinogenesis
UniProtKB/Swiss-Prot Function: Serine protease that proteolytically cleaves and activates the viral spike glycoproteins which facilitate virus-cell membrane fusions; spike proteins are synthesized and maintained in precursor intermediate folding states and proteolysis permits the refolding and energy release required to create stable virus-cell linkages and membrane coalescence. Facilitates human SARS coronavirus (SARS-CoV) infection via two independent mechanisms, proteolytic cleavage of ACE2, which might promote viral uptake, and cleavage of coronavirus spike glycoprotein which activates the glycoprotein for cathepsin L-independent host cell entry. Proteolytically cleaves and activates the spike glycoproteins of human coronavirus 229E (HCoV-229E) and human coronavirus EMC (HCoV-EMC) and the fusion glycoproteins F0 of Sendai virus (SeV), human metapneumovirus (HMPV), human parainfluenza 1, 2, 3, 4a and 4b viruses (HPIV). Essential for spread and pathogenesis of influenza A virus (strains H1N1, H3N2 and H7N9); involved in proteolytic cleavage and activation of hemagglutinin (HA) protein which is essential for viral infectivity.

Enzyme Numbers (IUBMB) for TMPRSS2 Gene

Gene Ontology (GO) - Molecular Function for TMPRSS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004252 serine-type endopeptidase activity IEA --
GO:0005044 scavenger receptor activity IEA --
GO:0005515 protein binding IPI 21068237
GO:0008236 serine-type peptidase activity TAS 9325052
genes like me logo Genes that share ontologies with TMPRSS2: view

Phenotypes for TMPRSS2 Gene

MGI mutant phenotypes for TMPRSS2:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with TMPRSS2: view

Animal Models for TMPRSS2 Gene

MGI Knock Outs for TMPRSS2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMPRSS2

In Situ Assay Products

Flow Cytometry Products

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for TMPRSS2 Gene

Localization for TMPRSS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMPRSS2 Gene

Cell membrane; Single-pass type II membrane protein.
Transmembrane protease serine 2 catalytic chain: Secreted. Note=Activated by cleavage and secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMPRSS2 Gene COMPARTMENTS Subcellular localization image for TMPRSS2 gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytosol 3
endoplasmic reticulum 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for TMPRSS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA 21068237
GO:0005887 integral component of plasma membrane TAS 9325052
GO:0016020 membrane --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with TMPRSS2: view

Pathways for TMPRSS2 Gene

genes like me logo Genes that share pathways with TMPRSS2: view

Pathways by source for TMPRSS2 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for TMPRSS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IDA 21068237
GO:0006898 receptor-mediated endocytosis IEA --
GO:0016540 protein autoprocessing IMP 21068237
GO:0046598 positive regulation of viral entry into host cell IDA 21068237
genes like me logo Genes that share ontologies with TMPRSS2: view

Compounds for TMPRSS2 Gene

(3) Novoseek inferred chemical compound relationships for TMPRSS2 Gene

Compound -log(P) Hits PubMed IDs
rubin 67.9 2
serine 50.4 18
testosterone 44.3 12
genes like me logo Genes that share compounds with TMPRSS2: view

Transcripts for TMPRSS2 Gene

Unigene Clusters for TMPRSS2 Gene

Transmembrane protease, serine 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMPRSS2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMPRSS2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b · 16c ^ 17a ·
SP1: - - - - - - - -
SP2: - - - -
SP3:
SP4: - -
SP5: - - - - - - - -
SP6: - -
SP7: - - - - -
SP8: -
SP9: -
SP10: -
SP11:

ExUns: 17b · 17c ^ 18a · 18b · 18c
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8: -
SP9:
SP10:
SP11: -

Relevant External Links for TMPRSS2 Gene

GeneLoc Exon Structure for
TMPRSS2
ECgene alternative splicing isoforms for
TMPRSS2

Expression for TMPRSS2 Gene

mRNA expression in normal human tissues for TMPRSS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMPRSS2 Gene

This gene is overexpressed in Prostate (10.6), Colon - Transverse (8.8), Stomach (7.1), and Pancreas (6.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TMPRSS2 Gene

SOURCE GeneReport for Unigene cluster for TMPRSS2 Gene Hs.439309

mRNA Expression by UniProt/SwissProt for TMPRSS2 Gene

O15393-TMPS2_HUMAN
Tissue specificity: Highly expressed in prostate epithelial cells and in prostate cancers. Expressed in type II pneumocytes in the lung (at protein level). Expressed strongly in small intestine. Also expressed in colon, stomach and salivary gland.
genes like me logo Genes that share expressions with TMPRSS2: view

In Situ Assay Products

Orthologs for TMPRSS2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMPRSS2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMPRSS2 35
  • 99.12 (n)
  • 97.96 (a)
TMPRSS2 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMPRSS2 35
  • 82.21 (n)
  • 78.73 (a)
TMPRSS2 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMPRSS2 35
  • 80.78 (n)
  • 78.83 (a)
TMPRSS2 36
  • 70 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmprss2 35
  • 77.64 (n)
  • 78.73 (a)
Tmprss2 16
Tmprss2 36
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMPRSS2 36
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMPRSS2 36
  • 70 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmprss2 35
  • 77.85 (n)
  • 78.53 (a)
chicken
(Gallus gallus)
Aves TMPRSS2 35
  • 65.46 (n)
  • 62.83 (a)
TMPRSS2 36
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMPRSS2 36
  • 58 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xesp-2 35
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101731874 35
  • 56.72 (n)
  • 50.86 (a)
Str.13039 35
zebrafish
(Danio rerio)
Actinopterygii tmprss2 35
  • 53.72 (n)
  • 48.12 (a)
tmprss2 36
  • 42 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG5197 37
  • 35 (a)
CG1299 37
  • 32 (a)
CG10663 37
  • 35 (a)
CG11192 37
  • 38 (a)
CG5246 37
  • 35 (a)
CG10405 37
  • 38 (a)
CG18065 37
  • 39 (a)
worm
(Caenorhabditis elegans)
Secernentea svh-1 35
  • 41.88 (n)
  • 32.1 (a)
ZK546.15 37
  • 32 (a)
Species with no ortholog for TMPRSS2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMPRSS2 Gene

ENSEMBL:
Gene Tree for TMPRSS2 (if available)
TreeFam:
Gene Tree for TMPRSS2 (if available)

Paralogs for TMPRSS2 Gene

genes like me logo Genes that share paralogs with TMPRSS2: view

Variants for TMPRSS2 Gene

Sequence variations from dbSNP and Humsavar for TMPRSS2 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type MAF
rs364289 -- 41,486,938(+) GGGGT(A/G)GGAGT intron-variant
rs365025 -- 41,487,140(+) cctaa(C/G)agtcc intron-variant
rs365724 -- 41,487,295(+) agaca(C/G)aaaca intron-variant
rs375408 -- 41,487,677(+) aaaaT(A/G)AATAA intron-variant
rs375760 -- 41,487,759(+) AGCTT(G/T)TTTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMPRSS2 Gene

Variant ID Type Subtype PubMed ID
nsv834102 CNV Loss 17160897
nsv459261 CNV Loss 19166990
nsv511631 CNV Gain 21212237
esv26806 CNV Gain 19812545
esv2723487 CNV Deletion 23290073
esv2723488 CNV Deletion 23290073
esv2723489 CNV Deletion 23290073
esv275165 CNV Loss 21479260

Relevant External Links for TMPRSS2 Gene

HapMap Linkage Disequilibrium report
TMPRSS2
Human Gene Mutation Database (HGMD)
TMPRSS2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMPRSS2 Gene

Disorders for TMPRSS2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for TMPRSS2 Gene including...

Search for TMPRSS2 Gene in MalaCards »

(1) University of Copenhagen DISEASES for TMPRSS2 Gene

(7) Novoseek inferred disease relationships for TMPRSS2 Gene

Disease -log(P) Hits PubMed IDs
prostate cancer 80.6 136
prostate carcinoma 44.9 4
cancer 37.5 9
tumors 33.6 18
carcinoma 33.1 2

Relevant External Links for TMPRSS2

Genetic Association Database (GAD)
TMPRSS2
Human Genome Epidemiology (HuGE) Navigator
TMPRSS2
genes like me logo Genes that share disorders with TMPRSS2: view

No data available for UniProtKB/Swiss-Prot for TMPRSS2 Gene

Publications for TMPRSS2 Gene

  1. Cloning of the TMPRSS2 gene, which encodes a novel serine protease with transmembrane, LDLRA, and SRCR domains and maps to 21q22.3. (PMID: 9325052) Paoloni-Giacobino A. … Antonarakis S.E. (Genomics 1997) 2 3 4 23
  2. Expression of transmembrane serine protease TMPRSS2 in mouse and human tissues. (PMID: 11169526) Vaarala M.H. … Vihko P.T. (J. Pathol. 2001) 3 4 23
  3. Met160Val polymorphism in the TRMPSS2 gene and risk of prostate cancer in a population-based case-control study. (PMID: 15065083) Lubieniecka J.M. … Ostrander E.A. (Prostate 2004) 3 23 48
  4. TMPRSS2, a serine protease expressed in the prostate on the apical surface of luminal epithelial cells and released into semen in prostasomes, is misregulated in prostate cancer cells. (PMID: 20382709) Chen Y.W. … Lin C.Y. (Am. J. Pathol. 2010) 3 4 23
  5. Association of SPINK1 expression and TMPRSS2:ERG fusion with prognosis in endocrine-treated prostate cancer. (PMID: 20442300) Leinonen K.A. … Visakorpi T. (Clin. Cancer Res. 2010) 3 23

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