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TMPRSS2 Gene

protein-coding GIFtS: 65

GC21M041750

transmembrane protease, serine 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase, and/or ⁹Nature:405,311-319 and CroW21)
About This Section

Aliases
EC 3.4.21.- ^³
FLJ41954 ^²
PP9284 ^²
PRSS10 ^¹, ², ³
epitheliasin ^²

Descriptions
Serine protease 10 ^³
transmembrane protease, serine 2 ^²
transmembrane protease, serine 2, EC 3.4.21 ⁹

External Ids
HGNC: 11876¹
Entrez Gene: 7113²
UniProtKB: O15393³
Ensembl: ENSG00000184012⁷

Search outside databases for aliases for TMPRSS2 gene

Previous GC identifers: GC21M039410 GC21M041757 GC21M041756

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for TMPRSS2:

This gene encodes a protein that belongs to the serine protease family. The encoded protein

contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor

cysteine-rich domain and a protease domain. Serine proteases are known to be involved in many

physiological and pathological processes. This gene was demonstrated to be up-regulated by

androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate

cancer tissue. The protease domain of this protein is thought to be cleaved and secreted into cell

media after autocleavage. Alternatively spliced transcript variants encoding different isoforms

have been found for this gene. [provided by RefSeq]

Gene Wiki entry for TMPRSS2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.3 Ensembl cytogenetic band: 21q22.3 HGNC cytogenetic band: 21q22.3
Nature(405: 311-319) cytogenetic band: 21q22.3

TMPRSS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 21 GeneLoc Exon Structure

(about GC identifiers)

GC21M041750:	GeneLoc	Nature:405,311-319
Start:	41,758,351 bp from pter	28,410,553 bp from centromere
End:	41,801,948 bp from pter	28,443,714 bp from centromere
Size:	43,598 bases	33,162 bases
Orientation:	minus strand	minus strand

RefSeq DNA sequence:

NC_000021.7 NT_011512.10

Whole chromosome sequencing:
cDNA sequence:	U75329
genomic clones:	Q87D5 to CIT2533B8

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: TMPS2_HUMAN, O15393 (See protein sequence)

Recommended Name: Transmembrane protease, serine 2 precursor

Size: 492 amino acids; 53859 Da

Subcellular location: Cell membrane; Single-pass type II membrane protein

Subcellular location: Transmembrane protease, serine 2 catalytic chain: Secreted. Note=Activated by

cleavage and secreted

Secondary accessions: Q6GTK7 Q9BXX1

REFSEQ proteins (2 alternative transcripts):

NP_001128571.1 NP_005647.3

ENSEMBL proteins:

ENSP00000381588 ENSP00000330330

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (TMPRSS2)
	Human Recombinant Proteins from Abnova (TMPRSS2)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005886	plasma membrane	IEA	--
GO:0005887	integral to plasma membrane	TAS	9325052

About this table

Antibodies for TMPRSS2:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for TMPRSS2
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (TMPRSS2), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (TMPRSS2)
	Novus Biologicals Antibody for TMPRSS2

Assays for TMPRSS2:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry O15393

ProtoNet protein and cluster: O15393

4 Blocks protein families:

IPB001190 Speract/scavenger receptor

IPB001254 Serine protease

IPB001314 Chymotrypsin serine protease family (S1) signature

IPB002172 Low density lipoprotein-receptor

UniProtKB/Swiss-Prot: TMPS2_HUMAN, O15393

Similarity: Belongs to the peptidase S1 family

Similarity: Contains 1 LDL-receptor class A domain

Similarity: Contains 1 peptidase S1 domain

Similarity: Contains 1 SRCR domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (TMPRSS2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (TMPRSS2)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005656

Applied Biosystems Silencer® siRNAs for TMPRSS2

Sigma-Aldrich siRNA and siRNA Panels for TMPRSS2

Sigma-Aldrich shRNA for TMPRSS2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for TMPRSS2
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_005656
Myc/DDK tagged cDNA clone in CMV expression vector: NM_005656
untagged cDNA clones in CMV expression vector (see all 4): NM_005656

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_005656

Genatlas biochemistry entry for TMPRSS2:

transmembrane protein,type II,strongly expressed in small intestine and in normal or carcinoid

cells of epithelial prostate,homologous to the enteropeptidase gene,potentially involved in

prostate carcinogenesis

1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Tmprss2):

normal

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004252	serine-type endopeptidase activity	IEA	--
GO:0005044	scavenger receptor activity	IEA	--
GO:0008233	peptidase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for TMPRSS2

5/12 Interacting proteins for TMPRSS2 (ENSP00000330330³) via UniProtKB, MINT, and/or STRING (see all 12 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
AR	ENSP00000363822³	STRING (score=.979)
ETV1	ENSP00000242066³	STRING (score=.961)
SLC45A3	ENSP00000356113³	STRING (score=.933)
C15orf21	ENSP00000313399³	STRING (score=.929)
HNRNPA2B1	ENSP00000346694³	STRING (score=.918)

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1 Gene Ontology (GO) biological process term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006508	proteolysis	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for TMPRSS2
1 Novoseek chemical compound relationship for TMPRSS2 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
rubin	71.73	2	17826676 (1), 17826677 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (TMPRSS2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (TMPRSS2)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005656

Sigma-Aldrich siRNA and siRNA Panels for TMPRSS2

Sigma-Aldrich shRNA for TMPRSS2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_005656

REFSEQ mRNAs for TMPRSS2 gene (2 alternative transcripts):

NM_001135099.1 NM_005656.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_005656

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_005656
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_005656
                                 untagged cDNA clones in CMV expression vector (see all 4): NM_005656

Additional cDNA sequence:

AF123453.1 AF270487.1 AF329454.1 AK092554.1 AK123948.1 AK222784.1 AK291813.1 AK296860.1

AK313338.1 BC015819.1 BC035623.1 BC051839.1 DQ204771.1 EU090249.1 U75329.1

18 DOTS entries:

DT.212263 DT.101982015 DT.100755214 DT.91757425 DT.86850243 DT.101982291 DT.91750049 DT.99997274

DT.101972563 DT.100682811 DT.121131591 DT.121131632 DT.40126200 DT.101982290 DT.121131617 DT.95273880

DT.95273881 DT.121131588

24/153 AceView cDNA sequences (see all 153 ):

BE857738 BM829557 CB989588 CB156146 AA904080 BQ083899 BQ082736 AF270487

BM747154 BX099916 CK430020 AA515387 AI668954 BM771081 BF001767 AI289207

CF145271 BU930003 BI761763 BM126828 BX508867 BF940659 AA225818 AW025029

highest scoring ESTs for TMPRSS2:

AF270487 AF329454 AI826806 AU099721 BC035623 BC051839 BI761763 BX508867 CF145271 CF147031

Unigene Cluster for TMPRSS2:

Transmembrane protease, serine 2

Hs.439309 [show with all ESTs]

Unigene Representative Sequence: AF329454

GeneLoc Exon Structure

5/11 Alternative Splicing Database (ASD) splice patterns (SP) for TMPRSS2 (see all 11 )

ExUns:	1a	·	1b	^	2	^	3	^	4a	·	4b	·	4c	^	5	^	6	^	7a	·	7b	^	8	^	9a	·	9b	^	10a	·	10b	·	10c	^	11	^	12	^	13	^	14	^	15	^	16a	·	16b	·	16c	^	17a	·
SP1:					-		-		-		-		-		-																														-						-
SP2:									-		-		-		-
SP3:
SP4:																									-		-
SP5:					-		-		-		-		-		-										-		-

ExUns:	17b	·	17c	^	18a	·	18b	·	18c
SP1:			-
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for TMPRSS2

2 Ensembl transcripts including schematic representations:

ENST00000398585 ENST00000332149

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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TMPRSS2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for TMPRSS2

¹ / ² / ³

8 probe-sets matching TMPRSS2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
34996_at²^{, 3}	U95-A	2	1.00	0.97	0.99	0.75	U75329	0.80	1.00	0.91	1
63329_at²^{, 3}	U95-C	1	0.62	1.00	0.99	1.26	AI826806	0.80	1.00	0.91	1
211689_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AF270487	0.80	1.00	0.91	1
205102_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_005656	0.60	1.00	0.82	1
226553_at²^{, 3}	U133-B	1	0.73	1.00	--	--	AI660243	0.60	1.00	0.82	1
211689_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
205102_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
226553_at²	U133Plus2	1	0.73	1.00	--	--	--	--	--	--	--

GeneDecks TMPRSS2 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CAAATAAATT

SOURCE GeneReport for Unigene cluster: Hs.439309
Expression variation in blood from EXPOLDB for TMPRSS2
UniProtKB/Swiss-Prot: TMPS2_HUMAN, O15393
Tissue specificity: Expressed strongly in small intestine. Also expressed in prostate, colon,
stomach and salivary gland

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for TMPRSS2 gene from 5/10 species (see all 10 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	TMPRSS2¹	--	transmembrane protease, serine 2	99.05(n) 97.76(a)	474007 XM_001172064.1 XP_001172064.1
cow (Bos taurus)	TMPRSS2¹	--	transmembrane protease, serine 2	82.21(n) 78.53(a)	511037 XM_588291.3 XP_588291.3
rat (Rattus norvegicus)	Tmprss2¹	--	transmembrane protease, serine 2	77.71(n) 78.32(a)	156435 NM_130424.2 NP_569108.2
mouse (Mus musculus)	Tmprss2^{1, 5}	16 (20.65 cM)⁵	transmembrane protease, serine 2^{1, 5}	77.51(n)¹ 78.53(a)¹	50528¹ NM_015775.2¹ NP_056590.2¹ AF113596⁵ AF199362⁵ (see all 20)
chicken (Gallus gallus)	TMPRSS2¹	--	transmembrane protease, serine 2	62.33(n) 60.17(a)	418528 XM_416737.2 XP_416737.2

About this table Species with no ortholog for TMPRSS2

ENSEMBL Gene Tree for TMPRSS2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for TMPRSS2 gene

TMPRSS3² TMPRSS4² TMPRSS13²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/325 NCBI SNPs in TMPRSS2 are shown (see all 325 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 138)

AB	SNP ID	Valid	Chr 21 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs456298^1,2	A,C,F,H,O	41758621(+)	`TTGCAA/TGACTT`	1	--	ut3¹		13	MN NA EU EA WA	1122
	rs456142^1,2	A,C,F,H,O	41758366(+)	`AAAATT/CGCATA`	1	--	ut3¹		5	NA MN EA WA	487
	rs462471^1,2	A,C,F,H	41758346(+)	`GCAGTG/AGTTAC`	1	--	ng5¹		7	NA EA WA	452
	rs2838038^1,2	C,F,H,O	41758555(+)	`TTCCAA/TGGTCC`	1	--	ut3¹ ese³		8	NA EU EA WA	575
	rs462574^1,2	A,C,F,H	41758599(+)	`CAGACG/AGATCC`	1	--	ut3¹		11	NA EU EA WA	851
	rs8127674^1,2	A,C,F,H	41803873(+)	`CTTTCA/GGCGGC`	1	--	ng3¹		4	EU EA WA	416
	rs12627374^1,2	C,F,H	41759561(+)	`CATGTC/TTCTCC`	1	--	ut3¹ trp³		4	EU EA WA	420
	rs12329760^1,2	C,F,H	41774367(+)	`GTACAC/TCTGAA`	1	V/M	mis¹ ese³		4	EU EA WA	420
	rs11910678^1,2	C,F,H	41758856(+)	`TTTGCT/CTCAGC`	1	--	ut3¹		11	NA EU EA WA	980
	rs12481984^1,2	C,F	41802764(+)	`actggT/Ctatgt`	1	--	ng3¹		1	NA	90

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HapMap Linkage Disequilibrium images for TMPRSS2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 602060

6 Novoseek disease relationships for TMPRSS2 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
prostate cancer	78.39	127	17334343 (6), 18519769 (6), 18500259 (6), 17172822 (5) (see all 48)
carcinoma	33.93	1	18550704 (1)
cancer	29.85	7	18338334 (2), 17079440 (1), 11745466 (1), 18794177 (1) (see all 6)
tumors	26.85	13	18500259 (2), 17079440 (1), 18385909 (1), 17334351 (1) (see all 8)
chromosomal aberrations	15.70	1	17334343 (1)
metastasis	14.64	6	18338334 (2), 18385909 (2)

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Genetic Association Database: TMPRSS2
Human Genome Epidemiology Navigator: TMPRSS2 (3 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

Histological Findings Reliable in Specific Gene-Fusion Prostate Cancer After Dutasteride Therapy: Presented at ASCP

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/92 PubMed articles for TMPRSS2 gene (see all 92 ):

Cloning of the TMPRSS2 gene, which encodes a novel serine protease with transmembrane, LDLRA, and SRCR domains and maps to 21q22.3. (PubMed id 9325052)^{1, 2, 3, 4} Paoloni-Giacobino A....Antonarakis S.E. (1997)
Expression of transmembrane serine protease TMPRSS2 in mouse and human tissues. (PubMed id 11169526)^{1, 3, 4} Vaarala M.H.... Vihko P.T. (2001)
Met160Val polymorphism in the TRMPSS2 gene and risk of prostate cancer in a population-based case-control study. (PubMed id 15065083)^{1, 3, 6} Lubieniecka J.M....Ostrander E.A. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Catalytic cleavage of the androgen-regulated TMPRSS2 protease results in its secretion by prostate and prostate cancer epithelia. (PubMed id 11245484)^{3, 4} Afar D.E.H.... Jakobovits A. (2001)
Mutation analyses of 268 candidate genes in human tumor cell lines. (PubMed id 11414763)^{3, 4} Teng D.-H.... Wong A.K.C. (2001)
Detection of TMPRSS2:ERG fusion gene in circulating prostate cancer cells. (PubMed id 18385909)^{1, 3} Mao X....Lu Y.J. (2008)
TMPRSS2:ERG fusion identifies a subgroup of prostate cancers with a favorable prognosis. (PubMed id 18519769)^{1, 3} Saramaki O.R....Visakorpi T. (2008)
Characterization of TMPRSS2:ETV5 and SLC45A3:ETV5 gene fusions in prostate cancer. (PubMed id 18172298)^{1, 3} Helgeson B.E....Chinnaiyan A.M. (2008)
Cloning and characterization of the cDNA and gene for human epitheliasin. (PubMed id 11322890)^{1, 3} Jacquinet E....Hoidal J.R. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 7113	HGNC: 11876	AceView: TMPRSS2	Ensembl:ENSG00000184012	euGenes: HUgn7113
ECgene: TMPRSS2	H-InvDB: TMPRSS2

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for TMPRSS2	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for TMPRSS2
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for TMPRSS2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for TMPRSS2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for TMPRSS2		Antibodies for TMPRSS2
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for TMPRSS2		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (TMPRSS2)
	Antibodies (TMPRSS2)
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	Custom Service for Rabbit Pab from Full-length Protein

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	Antibodies (TMPRSS2)

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Search Tocris compounds for TMPRSS2

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Antibodies for TMPRSS2

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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TMPRSS2 Gene at Home site.
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TMPRSS2 Gene

protein-coding GIFtS: 65

Aliases &
Descriptions
for TMPRSS2

Summaries
for TMPRSS2

Genomic Location
for TMPRSS2

Proteins
for TMPRSS2

Protein Domains/
Families
for TMPRSS2

Gene Function
for TMPRSS2

Pathways & Interactions
for TMPRSS2

Drugs & Compounds
for TMPRSS2

Transcripts
for TMPRSS2

Expression
for TMPRSS2

Orthologs
for TMPRSS2

Paralogs
for TMPRSS2

SNPs/Variants
for TMPRSS2

Disorders & Mutations
for TMPRSS2

Medical News
for TMPRSS2

Publications
for TMPRSS2

Search for TMPRSS2

Genome Databases showing TMPRSS2

Other Databases showing TMPRSS2

Specialized Databases showing TMPRSS2

Licensable Technologies
for TMPRSS2

Services
for TMPRSS2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

TMPRSS2 Gene

protein-coding GIFtS: 65

Aliases & Descriptionsfor TMPRSS2

Summariesfor TMPRSS2

Genomic Locationfor TMPRSS2

Proteinsfor TMPRSS2

Protein Domains/Familiesfor TMPRSS2

Gene Functionfor TMPRSS2

Pathways & Interactionsfor TMPRSS2

Drugs & Compoundsfor TMPRSS2

Transcriptsfor TMPRSS2

Expression for TMPRSS2

Orthologsfor TMPRSS2

Paralogsfor TMPRSS2

SNPs/Variantsfor TMPRSS2

Disorders & Mutationsfor TMPRSS2

Medical Newsfor TMPRSS2

Publicationsfor TMPRSS2

Search for TMPRSS2

Genome Databases showing TMPRSS2

Other Databases showing TMPRSS2

Specialized Databases showing TMPRSS2

Licensable Technologiesfor TMPRSS2

Servicesfor TMPRSS2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for TMPRSS2

Summaries
for TMPRSS2

Genomic Location
for TMPRSS2

Proteins
for TMPRSS2

Protein Domains/
Families
for TMPRSS2

Gene Function
for TMPRSS2

Pathways & Interactions
for TMPRSS2

Drugs & Compounds
for TMPRSS2

Transcripts
for TMPRSS2

Expression
for TMPRSS2

Orthologs
for TMPRSS2

Paralogs
for TMPRSS2

SNPs/Variants
for TMPRSS2

Disorders & Mutations
for TMPRSS2

Medical News
for TMPRSS2

Publications
for TMPRSS2

Licensable Technologies
for TMPRSS2

Services
for TMPRSS2