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TMPRSS2 Gene

protein-coding   GIFtS: 65
GCID: GC21M042836

Transmembrane Protease, Serine 2

  See TMPRSS2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, 15RNAdb, and/or 11Nature:405,311-319 and CroW21)
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Aliases
Transmembrane Protease, Serine 21 2     epitheliasin2
Serine Protease 102 3     Transmembrane Protease Serine 22
PRSS102 3     EC 3.4.21.-3
Transmembrane Protease, Serine 2, EC 3.4.2111     EC 3.4.218
PP92842     EC 3.4.21.1098

External Ids:    HGNC: 118761   Entrez Gene: 71132   Ensembl: ENSG000001840127   OMIM: 6020605   UniProtKB: O153933   

Export aliases for TMPRSS2 gene to outside databases

Previous GC identifers: GC21M039410 GC21M041757 GC21M041756 GC21M041750 GC21M028305


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TMPRSS2 Gene:
This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a type II
transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain.
Serine proteases are known to be involved in many physiological and pathological processes. This gene was
demonstrated to be up-regulated by androgenic hormones in prostate cancer cells and down-regulated in
androgen-independent prostate cancer tissue. The protease domain of this protein is thought to be cleaved and
secreted into cell media after autocleavage. Alternatively spliced transcript variants encoding different
isoforms have been found for this gene. (provided by RefSeq, Sep 2008)

GeneCards Summary for TMPRSS2 Gene:
TMPRSS2 (transmembrane protease, serine 2) is a protein-coding gene. Diseases associated with TMPRSS2 include prostate cancer. GO annotations related to this gene include scavenger receptor activity and serine-type endopeptidase activity. An important paralog of this gene is TMPRSS11D.

Gene Wiki entry for TMPRSS2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
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RefSeq DNA sequence at NCBI GenBank:
NC_000021.8  NT_011512.12  NC_018932.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TMPRSS2 gene promoter:
         Bach1   SREBP-1c   RelA   SREBP-1b   Ik-2   STAT3   NF-Y   Ik-1   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TMPRSS2 promoter sequence

   Search Chromatin IP Primers for TMPRSS2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TMPRSS2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.3   Ensembl cytogenetic band:  21q22.3   HGNC cytogenetic band: 21q22.3
Nature(405: 311-319) cytogenetic band:   21q22.3
TMPRSS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMPRSS2 gene location
GeneLoc information about chromosome 21         GeneLoc Exon Structure

(about GC identifiers)
GC21M042836:   GeneLoc Nature:405,311-319
Start:
42,836,478 bp from pter       28,410,553 bp from centromere
End:
42,903,043 bp from pter 28,443,714 bp from centromere
Size:
66,566 bases 33,162 bases
Orientation:
minus strand minus strand

Whole chromosome sequencing:
cDNA sequence: U75329
genomic clones: Q87D5 to CIT2533B8


(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TMPS2_HUMAN, O15393 (See protein sequence)
Recommended Name: Transmembrane protease serine 2 precursor  
Size: 492 amino acids; 53859 Da
Secondary accessions: A8K6Z8 B2R8E5 B7Z459 D3DSJ2 F8WES1 Q6GTK7 Q9BXX1
Alternative splicing: 2 isoforms:  O15393-1   O15393-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TMPRSS2: NX_O15393

Explore proteomics data for TMPRSS2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn213, Asn249
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for TMPRSS2 (O15393) (see all 6)
     GDSGGPL  WPWQVSL  CWISGWG  CQGDSGGP 


    See TMPRSS2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001128571.1  NP_005647.3  

    ENSEMBL proteins: 
     ENSP00000330330   ENSP00000391216   ENSP00000389006   ENSP00000397846   ENSP00000391784  
     ENSP00000381588  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TMPRSS: Serine peptidases / Transmembrane

    Selected InterPro protein domains (see all 8):
     IPR002172 LDrepeatLR_classA_rpt
     IPR001314 Peptidase_S1A
     IPR001190 SRCR
     IPR023415 LDLR_class-A_CS
     IPR009003 Trypsin-like_Pept_dom

    Graphical View of Domain Structure for InterPro Entry O15393

    ProtoNet protein and cluster: O15393

    4 Blocks protein domains:
    IPB001190 Speract/scavenger receptor
    IPB001254 Serine protease
    IPB001314 Chymotrypsin serine protease family (S1) signature
    IPB002172 Low density lipoprotein-receptor


    UniProtKB/Swiss-Prot: TMPS2_HUMAN, O15393
    Similarity: Belongs to the peptidase S1 family
    Similarity: Contains 1 LDL-receptor class A domain
    Similarity: Contains 1 peptidase S1 domain
    Similarity: Contains 1 SRCR domain


    Find genes that share domains with TMPRSS2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:
         Genatlas biochemistry entry for TMPRSS2:
    transmembrane protein,type II,strongly expressed in small intestine and in normal or carcinoid cells of epithelial
    prostate,homologous to the enteropeptidase gene,potentially involved in prostate carcinogenesis

         Enzyme Numbers (IUBMB): EC 3.4.212 EC 3.4.21.1092 EC 3.4.21.-1

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004252serine-type endopeptidase activity IEA--
    GO:0005044scavenger receptor activity IEA--
    GO:0005515protein binding ----
    GO:0008236serine-type peptidase activity TAS9325052
         
    Find genes that share ontologies with TMPRSS2           About GenesLikeMe


    Phenotypes:
         1 MGI mutant phenotype (inferred from 2 alleles(MGI details for Tmprss2):
     normal 

    Find genes that share phenotypes with TMPRSS2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for TMPRSS2: Tmprss2tm1Lex Tmprss2tm1Tsyk

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    SwitchGear 3'UTR luciferase reporter plasmidTMPRSS2 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TMPS2_HUMAN, O15393: Cell membrane; Single-pass type II membrane protein
    TMPS2_HUMAN, O15393: Transmembrane protease serine 2 catalytic chain: Secreted. Note=Activated by cleavage and
    secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane5
    cytosol3
    endoplasmic reticulum1
    mitochondrion1
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0005737cytoplasm ----
    GO:0005886plasma membrane ----
    GO:0005887integral component of plasma membrane TAS9325052
    GO:0016020membrane ----

    Find genes that share ontologies with TMPRSS2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TMPRSS2 About    
    See pathways by source

    SuperPathContained pathways About
    1Influenza A
    Influenza A0.34
    2Transcriptional misregulation in cancer
    Transcriptional misregulation in cancer
    3Regulation of Androgen receptor activity
    Regulation of Androgen receptor activity
    4Coregulation of Androgen receptor activity
    Coregulation of Androgen receptor activity


    Find genes that share SuperPaths with TMPRSS2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for TMPRSS2
        Regulation of Androgen receptor activity
    Coregulation of Androgen receptor activity



    2 Kegg Pathways  (Kegg details for TMPRSS2):
        Influenza A
    Transcriptional misregulation in cancer

        Pathway & Disease-focused RT2 Profiler PCR Array including TMPRSS2: 
              Prostate Cancer in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TMPRSS2

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for TMPRSS2 (O153933 ENSP000003303304) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARP102753, ENSP000003638224I2D: score=1 STRING: ENSP00000363822
    CREBBPQ927933, ENSP000002623674I2D: score=1 STRING: ENSP00000262367
    ERGP113083, ENSP000003818914I2D: score=1 STRING: ENSP00000381891
    KDM3AENSP000003236594STRING: ENSP00000323659
    POU2F1ENSP000002714114STRING: ENSP00000271411
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis ----

    Find genes that share ontologies with TMPRSS2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TMPRSS2 (TMPS2)

    3 Novoseek inferred chemical compound relationships for TMPRSS2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rubin 67.9 2 17826676 (1), 17826677 (1)
    serine 50.4 25 20382709 (3), 15879706 (2), 9325052 (2), 11745466 (2) (see all 13)
    testosterone 44.3 26 20308527 (3), 20147525 (2), 19584279 (2), 20478527 (1) (see all 8)



    Find genes that share compounds with TMPRSS2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TMPRSS2 gene (2 alternative transcripts): 
    NM_001135099.1  NM_005656.3  

    Unigene Cluster for TMPRSS2:

    Transmembrane protease, serine 2
    Hs.439309  [show with all ESTs]
    Unigene Representative Sequence: NM_001135099
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000332149(uc002yzj.3) ENST00000488556 ENST00000458356 ENST00000454499(uc010gos.1)
    ENST00000469395 ENST00000424093 ENST00000497881 ENST00000463138 ENST00000455813
    ENST00000489201 ENST00000398585(uc010gor.3)
    miRNA
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    hsa-let-7d hsa-miR-202 hsa-let-7c hsa-miR-513c hsa-let-7g hsa-let-7a hsa-miR-15b* hsa-miR-1208
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    Additional mRNA sequence: 

    AF123453.1 AF270487.1 AF329454.1 AK092554.1 AK123948.1 AK222784.1 AK291813.1 AK296860.1 
    AK313338.1 BC015819.1 BC035623.1 BC051839.1 DQ204771.1 EU090249.1 HM245389.1 HM245390.1 
    U75329.1 

    16 DOTS entries:

    DT.212263  DT.101982015  DT.100755214  DT.91757425  DT.101982291  DT.86850243  DT.99997274  DT.101972563 
    DT.100682811  DT.121131632  DT.101982290  DT.121131591  DT.121131617  DT.95273881  DT.121131588  DT.95273880 

    Selected AceView cDNA sequences (see all 153):

    AF270487 CB989588 BE857738 CK430020 AI668954 BQ083899 AA904080 CB156146 
    BX099916 BM771081 BM829557 BQ082736 BM747154 AA515387 CK906287 BM126828 
    AI865551 BC035623 BI761763 BC051839 AW025029 AI821436 BC015819 BP342437 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TMPRSS2 (see all 11)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b · 16c ^ 17a ·
    SP1:              -     -     -     -     -     -                                                                                         -                 -   
    SP2:                          -     -     -     -                                                                                                               
    SP3:                                                                                                                                                            
    SP4:                                                                          -     -                                                                           
    SP5:              -     -     -     -     -     -                             -     -                                                                           

    ExUns: 17b · 17c ^ 18a · 18b · 18c
    SP1:        -                     
    SP2:                              
    SP3:                              
    SP4:                              
    SP5:                              


    ECgene alternative splicing isoforms for TMPRSS2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TMPRSS2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAAATAAATT
    TMPRSS2 Expression
    About this image


    TMPRSS2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Kidney (Urinary System)    fully expand to see all 6 entries
             Ureteric Bud Cells Ureteric Bud
             Metanephros
     
     Lung (Respiratory System)
             Alveolar type II cells
     
     Colon (Gastrointestinal Tract)
     
     Prostate (Endocrine System)
    TMPRSS2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TMPRSS2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.439309

    UniProtKB/Swiss-Prot: TMPS2_HUMAN, O15393
    Tissue specificity: Expressed strongly in small intestine. Also expressed in prostate, colon, stomach and salivary
    gland

        Pathway & Disease-focused RT2 Profiler PCR Array including TMPRSS2: 
              Prostate Cancer in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TMPRSS2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tmprss21 , 5 transmembrane protease, serine 21, 5 77.64(n)1
    78.73(a)1
      16 (57.53 cM)5
    505281  NM_015775.21  NP_056590.21 
     975646845 
    chicken
    (Gallus gallus)
    Aves TMPRSS21 transmembrane protease, serine 2 65.46(n)
    62.83(a)
      418528  XM_416737.4  XP_416737.3 
    lizard
    (Anolis carolinensis)
    Reptilia TMPRSS26
    transmembrane protease, serine 2
    58(a)
    1 ↔ 1
    3(138399391-138427594)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xesp-22 embryonic serine protease-2 75.58(n)    AB038497.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tmprss21 transmembrane protease, serine 2 53.72(n)
    48.12(a)
      494080  NM_001008623.1  NP_001008623.1 
    worm
    (Caenorhabditis elegans)
    Secernentea ZK546.153
    svh-11
    Plasminogen3
    svh-11
    32(a)3
    41.88(n)1
    32.1(a)1
      II(4948250-4949451)3
    1823751  NM_068978.31  NP_501379.21 


    ENSEMBL Gene Tree for TMPRSS2 (if available)
    TreeFam Gene Tree for TMPRSS2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TMPRSS2 gene
    TMPRSS11D2  TMPRSS32  TMPRSS11B2  TMPRSS62  TMPRSS11A2  TMPRSS72  TMPRSS52  TMPRSS42  
    ST142  TMPRSS132  TMPRSS11E2  KLKB12  F112  HPN2  TMPRSS152  TMPRSS11F2  
    Selected SIMAP similar genes for TMPRSS2 using alignment to 5 protein entries:     TMPS2_HUMAN (see all proteins) (see all similar genes):
    MGC52282    DESC1    PRSS46    TMPRSS11B    TMPRSS11E    PROC1
    TMPRSS11A    TMPRSS11F    PROC    CELA2B    PRSS42    TMPRSS11D
    TMPRSS3    DKFZp586F0824    TMPRSS12    KLKB1    PRSS22    PRSS1

    Find genes that share paralogs with TMPRSS2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TMPRSS2 (see all 1191)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 21 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs110885501,2
    C--42835994(+) TGGGAA/GGGACC 2 -- ds50010--------
    rs1441574411,2
    --42836039(+) TTCCTA/GTGCTG 2 -- ds50010--------
    rs1473499301,2
    --42836120(+) TCTCCC/TTGCCT 2 -- ds50010--------
    rs1818749571,2
    --42836127(+) GCCTGC/TTGCCA 2 -- ds50010--------
    rs1864848711,2
    --42836137(+) ATCCAC/TGTAAG 2 -- ds50010--------
    rs1913688761,2
    --42836149(+) TGTGAC/TTTGCT 2 -- ds50010--------
    rs4637271,2
    C,F,A,H--42836186(+) aggccT/Acccca 2 -- ds50015Minor allele frequency- A:0.50NA CSA 10
    rs81297691,2
    C,H--42836344(+) CTGAGG/AGCACC 2 -- ds50014Minor allele frequency- A:0.00NS EA 420
    rs1811621341,2
    --42836475(+) TGCAGC/TAGTTA 2 -- ds50010--------
    rs4624711,2
    C,F,A,H--42836476(+) GCAGTG/AGTTAC 2 -- ds500125Minor allele frequency- A:0.35NA NS EA CSA WA 2213

    HapMap Linkage Disequilibrium report for TMPRSS2 (42836478 - 42903043 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for TMPRSS2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2723489CNV Deletion23290073
    esv2723487CNV Deletion23290073
    esv2723488CNV Deletion23290073
    esv275165CNV Loss21479260
    nsv834102CNV Loss17160897
    nsv459261CNV Loss19166990
    esv26806CNV Gain19812545
    nsv511631CNV Gain21212237

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602060    OMIM disorders: --

    1 disease for TMPRSS2:    
    About MalaCards
    prostate cancer

    1 disease from the University of Copenhagen DISEASES database for TMPRSS2:
    Prostate cancer

    Find genes that share disorders with TMPRSS2           About GenesLikeMe

    7 Novoseek inferred disease relationships for TMPRSS2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    prostate cancer 80.6 164 17334343 (6), 18519769 (6), 18500259 (6), 17172822 (5) (see all 64)
    prostate carcinoma 44.9 4 19465903 (3), 19642730 (1)
    cancer 37.5 10 18338334 (2), 17079440 (1), 19242826 (1), 11745466 (1) (see all 8)
    tumors 33.6 26 19597533 (2), 19242826 (2), 19494719 (2), 18500259 (2) (see all 14)
    carcinoma 33.1 2 18550704 (1), 19465903 (1)
    metastasis 11.6 6 18338334 (2), 18385909 (2)
    chromosomal aberrations 9.84 1 17334343 (1)

    Genetic Association Database (GAD): TMPRSS2
    Human Genome Epidemiology (HuGE) Navigator: TMPRSS2 (4 documents)

    Export disorders for TMPRSS2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TMPRSS2 gene, integrated from 10 sources (see all 174):
    (articles sorted by number of sources associating them with TMPRSS2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of the TMPRSS2 gene, which encodes a novel serine protease with transmembrane, LDLRA, and SRCR domains and maps to 21q22.3. (PubMed id 9325052)1, 2, 3, 9 Paoloni-Giacobino A....Antonarakis S.E. (Genomics 1997)
    2. Expression of transmembrane serine protease TMPRSS2 in mouse and human tissues. (PubMed id 11169526)1, 2, 9 Vaarala M.H.... Vihko P.T. (J. Pathol. 2001)
    3. Met160Val polymorphism in the TRMPSS2 gene and risk of prostate cancer in a population-based case-control study. (PubMed id 15065083)1, 4, 9 Lubieniecka J.M....Ostrander E.A. (Prostate 2004)
    4. Association of TMPRSS2-ERG gene fusion with clinical characteristics and outcomes: results from a population-based study of prostate cancer. (PubMed id 18694509)1, 4 FitzGerald L.M....Huntsman D.G. (BMC Cancer 2008)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Catalytic cleavage of the androgen-regulated TMPRSS2 protease results in its secretion by prostate and prostate cancer epithelia. (PubMed id 11245484)1, 2 Afar D.E.H.... Jakobovits A. (Cancer Res. 2001)
    7. Mutation analyses of 268 candidate genes in human tumor cell lines. (PubMed id 11414763)1, 2 Teng D.-H.... Wong A.K.C. (Genomics 2001)
    8. The DNA sequence of human chromosome 21. (PubMed id 10830953)1, 2 Hattori M.... Yaspo M.-L. (Nature 2000)
    9. Detection of TMPRSS2:ERG fusion gene in circulating prostate cancer cells. (PubMed id 18385909)1, 9 Mao X....Lu Y.J. (Asian J. Androl. 2008)
    10. Quantitative expression of TMPRSS2 transcript in prostate tumor cells reflects TMPRSS2-ERG fusion status. (PubMed id 19597533)1, 9 Mwamukonda K....Petrovics G. (Prostate Cancer Prostatic Dis. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7113 HGNC: 11876 AceView: TMPRSS2 Ensembl:ENSG00000184012 euGenes: HUgn7113
    ECgene: TMPRSS2 Kegg: 7113 H-InvDB: TMPRSS2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TMPRSS2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TMPRSS2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TMPRSS2 gene:
    Search GeneIP for patents involving TMPRSS2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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