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Aliases for TMPRSS2 Gene

Aliases for TMPRSS2 Gene

  • Transmembrane Protease, Serine 2 2 3 5
  • Serine Protease 10 3 4
  • PRSS10 3 4
  • Transmembrane Protease Serine 2 3
  • EC 3.4.21.109 61
  • Epitheliasin 3
  • EC 3.4.21.- 4
  • EC 3.4.21 61
  • PP9284 3

External Ids for TMPRSS2 Gene

Previous GeneCards Identifiers for TMPRSS2 Gene

  • GC21M039410
  • GC21M041757
  • GC21M041756
  • GC21M041750
  • GC21M042836
  • GC21M028305

Summaries for TMPRSS2 Gene

Entrez Gene Summary for TMPRSS2 Gene

  • This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Serine proteases are known to be involved in many physiological and pathological processes. This gene was demonstrated to be up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate cancer tissue. The protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]

CIViC summary for TMPRSS2 Gene

GeneCards Summary for TMPRSS2 Gene

TMPRSS2 (Transmembrane Protease, Serine 2) is a Protein Coding gene. Diseases associated with TMPRSS2 include Prostatic Acinar Adenocarcinoma and Prostate Cancer 1. Among its related pathways are Influenza A and Transcriptional misregulation in cancer. GO annotations related to this gene include serine-type endopeptidase activity and scavenger receptor activity. An important paralog of this gene is TMPRSS3.

UniProtKB/Swiss-Prot for TMPRSS2 Gene

  • Serine protease that proteolytically cleaves and activates the viral spike glycoproteins which facilitate virus-cell membrane fusions; spike proteins are synthesized and maintained in precursor intermediate folding states and proteolysis permits the refolding and energy release required to create stable virus-cell linkages and membrane coalescence. Facilitates human SARS coronavirus (SARS-CoV) infection via two independent mechanisms, proteolytic cleavage of ACE2, which might promote viral uptake, and cleavage of coronavirus spike glycoprotein which activates the glycoprotein for cathepsin L-independent host cell entry. Proteolytically cleaves and activates the spike glycoproteins of human coronavirus 229E (HCoV-229E) and human coronavirus EMC (HCoV-EMC) and the fusion glycoproteins F0 of Sendai virus (SeV), human metapneumovirus (HMPV), human parainfluenza 1, 2, 3, 4a and 4b viruses (HPIV). Essential for spread and pathogenesis of influenza A virus (strains H1N1, H3N2 and H7N9); involved in proteolytic cleavage and activation of hemagglutinin (HA) protein which is essential for viral infectivity.

Gene Wiki entry for TMPRSS2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMPRSS2 Gene

Genomics for TMPRSS2 Gene

Regulatory Elements for TMPRSS2 Gene

Enhancers for TMPRSS2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH21G041496 1.7 FANTOM5 ENCODE dbSUPER 14.1 +27.3 27323 14.6 CREB3L1 MLX AGO1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC ZNF610 PRDM15 MX2 TMPRSS2 ENSG00000207503 FAM3B ABCG1 GC21P041463
GH21G041557 1.2 ENCODE dbSUPER 12.2 -28.9 -28927 5.8 PKNOX1 ZFP64 E2F7 TCF12 GATA2 FOS JUNB ZNF662 TBX21 SMARCA4 ENSG00000207503 TMPRSS2 LINC00112 LINC00479 ENSG00000232806
GH21G041611 1.3 Ensembl ENCODE dbSUPER 11.1 -83.5 -83462 5.6 CTCF FOXA2 NFIB TEAD4 SIN3A RAD21 FOSL1 ZNF121 MTA3 CTBP1 TMPRSS2 LINC00112 LINC00479 ENSG00000207503 LOC105372809 LOC105372812
GH21G041485 1 Ensembl ENCODE dbSUPER 10.2 +44.7 44705 2.2 ZFHX2 EP300 EGR2 RBFOX2 TMPRSS2 GC21P041463
GH21G041477 1.1 ENCODE dbSUPER 8.4 +53.0 53019 1.9 CTCF RB1 ZFP64 JUN TEAD4 ZNF223 MAX ZIC2 RAD21 POLR2A TMPRSS2 GC21P041463
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMPRSS2 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMPRSS2 Gene

Chromosome:
21
Start:
41,464,551 bp from pter
End:
41,531,116 bp from pter
Size:
66,566 bases
Orientation:
Minus strand

Genomic View for TMPRSS2 Gene

Genes around TMPRSS2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMPRSS2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMPRSS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMPRSS2 Gene

Proteins for TMPRSS2 Gene

  • Protein details for TMPRSS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15393-TMPS2_HUMAN
    Recommended name:
    Transmembrane protease serine 2
    Protein Accession:
    O15393
    Secondary Accessions:
    • A8K6Z8
    • B2R8E5
    • B7Z459
    • D3DSJ2
    • F8WES1
    • Q6GTK7
    • Q9BXX1

    Protein attributes for TMPRSS2 Gene

    Size:
    492 amino acids
    Molecular mass:
    53859 Da
    Quaternary structure:
    • The catalytically active form interacts with ACE2.

    Alternative splice isoforms for TMPRSS2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMPRSS2 Gene

Selected DME Specific Peptides for TMPRSS2 Gene

O15393:
  • DSCQGDSGG
  • CWISGWG
  • GDSGGPL
  • WPWQVSLH
  • CQGDSGGP
  • WPWQVSL

Post-translational modifications for TMPRSS2 Gene

  • Proteolytically processed; by an autocatalytic mechanism.
  • Glycosylation at isoforms=2213 and posLast=249249
  • Modification sites at PhosphoSitePlus

Domains & Families for TMPRSS2 Gene

Suggested Antigen Peptide Sequences for TMPRSS2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O15393

UniProtKB/Swiss-Prot:

TMPS2_HUMAN :
  • Belongs to the peptidase S1 family.
Family:
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with TMPRSS2: view

Function for TMPRSS2 Gene

Molecular function for TMPRSS2 Gene

GENATLAS Biochemistry:
transmembrane protein,type II,strongly expressed in small intestine and in normal or carcinoid cells of epithelial prostate,homologous to the enteropeptidase gene,potentially involved in prostate carcinogenesis
UniProtKB/Swiss-Prot Function:
Serine protease that proteolytically cleaves and activates the viral spike glycoproteins which facilitate virus-cell membrane fusions; spike proteins are synthesized and maintained in precursor intermediate folding states and proteolysis permits the refolding and energy release required to create stable virus-cell linkages and membrane coalescence. Facilitates human SARS coronavirus (SARS-CoV) infection via two independent mechanisms, proteolytic cleavage of ACE2, which might promote viral uptake, and cleavage of coronavirus spike glycoprotein which activates the glycoprotein for cathepsin L-independent host cell entry. Proteolytically cleaves and activates the spike glycoproteins of human coronavirus 229E (HCoV-229E) and human coronavirus EMC (HCoV-EMC) and the fusion glycoproteins F0 of Sendai virus (SeV), human metapneumovirus (HMPV), human parainfluenza 1, 2, 3, 4a and 4b viruses (HPIV). Essential for spread and pathogenesis of influenza A virus (strains H1N1, H3N2 and H7N9); involved in proteolytic cleavage and activation of hemagglutinin (HA) protein which is essential for viral infectivity.

Enzyme Numbers (IUBMB) for TMPRSS2 Gene

Gene Ontology (GO) - Molecular Function for TMPRSS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004252 serine-type endopeptidase activity IEA --
GO:0005044 scavenger receptor activity IEA --
GO:0005515 protein binding IPI 21068237
GO:0008233 peptidase activity IEA --
GO:0008236 serine-type peptidase activity TAS 9325052
genes like me logo Genes that share ontologies with TMPRSS2: view
genes like me logo Genes that share phenotypes with TMPRSS2: view

Animal Models for TMPRSS2 Gene

MGI Knock Outs for TMPRSS2:

Animal Model Products

  • Taconic Biosciences Mouse Models for TMPRSS2

CRISPR Products

Inhibitory RNA Products

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for TMPRSS2 Gene

Localization for TMPRSS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMPRSS2 Gene

Cell membrane; Single-pass type II membrane protein.
Transmembrane protease serine 2 catalytic chain: Secreted. Note=Activated by cleavage and secreted. {ECO:0000269 PubMed:20382709}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMPRSS2 gene
Compartment Confidence
plasma membrane 5
extracellular 5
nucleus 2
endosome 2
mitochondrion 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for TMPRSS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane IDA,IEA 21068237
GO:0005887 integral component of plasma membrane TAS 9325052
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMPRSS2: view

Pathways & Interactions for TMPRSS2 Gene

genes like me logo Genes that share pathways with TMPRSS2: view

Pathways by source for TMPRSS2 Gene

Gene Ontology (GO) - Biological Process for TMPRSS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IDA 21068237
GO:0006898 receptor-mediated endocytosis IEA --
GO:0016540 protein autoprocessing IMP 21068237
GO:0046598 positive regulation of viral entry into host cell IDA 21068237
genes like me logo Genes that share ontologies with TMPRSS2: view

No data available for SIGNOR curated interactions for TMPRSS2 Gene

Drugs & Compounds for TMPRSS2 Gene

(2) Drugs for TMPRSS2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for TMPRSS2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TMPRSS2: view

Transcripts for TMPRSS2 Gene

Unigene Clusters for TMPRSS2 Gene

Transmembrane protease, serine 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMPRSS2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b · 16c ^ 17a ·
SP1: - - - - - - - -
SP2: - - - -
SP3:
SP4: - -
SP5: - - - - - - - -
SP6: - -
SP7: - - - - -
SP8: -
SP9: -
SP10: -
SP11:

ExUns: 17b · 17c ^ 18a · 18b · 18c
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8: -
SP9:
SP10:
SP11: -

Relevant External Links for TMPRSS2 Gene

GeneLoc Exon Structure for
TMPRSS2
ECgene alternative splicing isoforms for
TMPRSS2

Expression for TMPRSS2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMPRSS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMPRSS2 Gene

This gene is overexpressed in Prostate (x10.6), Colon - Transverse (x8.8), Stomach (x7.1), and Pancreas (x6.5).

Protein differential expression in normal tissues from HIPED for TMPRSS2 Gene

This gene is overexpressed in Amniocyte (60.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TMPRSS2 Gene



NURSA nuclear receptor signaling pathways regulating expression of TMPRSS2 Gene:

TMPRSS2

SOURCE GeneReport for Unigene cluster for TMPRSS2 Gene:

Hs.439309

mRNA Expression by UniProt/SwissProt for TMPRSS2 Gene:

O15393-TMPS2_HUMAN
Tissue specificity: Highly expressed in prostate epithelial cells and in prostate cancers. Expressed in type II pneumocytes in the lung (at protein level). Expressed strongly in small intestine. Also expressed in colon, stomach and salivary gland.

Evidence on tissue expression from TISSUES for TMPRSS2 Gene

  • Liver(4.2)
  • Nervous system(4)
  • Intestine(2.9)
  • Lung(2.3)
  • Urine(2.1)
  • Kidney(2)
  • Stomach(2)
genes like me logo Genes that share expression patterns with TMPRSS2: view

Primer Products

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMPRSS2 Gene

Orthologs for TMPRSS2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMPRSS2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMPRSS2 34 35
  • 99.12 (n)
cow
(Bos Taurus)
Mammalia TMPRSS2 34 35
  • 82.21 (n)
dog
(Canis familiaris)
Mammalia TMPRSS2 34 35
  • 80.78 (n)
rat
(Rattus norvegicus)
Mammalia Tmprss2 34
  • 77.85 (n)
mouse
(Mus musculus)
Mammalia Tmprss2 34 16 35
  • 77.64 (n)
oppossum
(Monodelphis domestica)
Mammalia TMPRSS2 35
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMPRSS2 35
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMPRSS2 34 35
  • 65.46 (n)
lizard
(Anolis carolinensis)
Reptilia TMPRSS2 35
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101731874 34
  • 56.72 (n)
Str.13039 34
African clawed frog
(Xenopus laevis)
Amphibia Xesp-2 34
zebrafish
(Danio rerio)
Actinopterygii tmprss2 34 35
  • 53.72 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG18065 36
  • 39 (a)
CG10405 36
  • 38 (a)
CG11192 36
  • 38 (a)
CG10663 36
  • 35 (a)
CG5197 36
  • 35 (a)
CG5246 36
  • 35 (a)
CG1299 36
  • 32 (a)
worm
(Caenorhabditis elegans)
Secernentea svh-1 34
  • 41.88 (n)
ZK546.15 36
  • 32 (a)
Species where no ortholog for TMPRSS2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMPRSS2 Gene

ENSEMBL:
Gene Tree for TMPRSS2 (if available)
TreeFam:
Gene Tree for TMPRSS2 (if available)

Paralogs for TMPRSS2 Gene

genes like me logo Genes that share paralogs with TMPRSS2: view

Variants for TMPRSS2 Gene

Sequence variations from dbSNP and Humsavar for TMPRSS2 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
rs193920966 Uncertain significance 41,468,487(-) AGACA(-/CA)GAGAT intron-variant, reference, frameshift-variant
rs1000072663 -- 41,471,057(+) AGCCA(A/G)AAAGC intron-variant
rs1000133479 -- 41,509,398(+) ACCTC(A/C)GCCTC upstream-variant-2KB
rs1000165575 -- 41,492,701(+) CAACT(G/T)ATAAG intron-variant
rs1000232927 -- 41,497,522(+) AAAAA(A/C)TGAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMPRSS2 Gene

Variant ID Type Subtype PubMed ID
dgv7835n54 CNV loss 21841781
dgv7836n54 CNV gain 21841781
dgv7837n54 CNV gain 21841781
dgv7838n54 CNV gain 21841781
dgv7839n54 CNV gain+loss 21841781
dgv7840n54 CNV loss 21841781
dgv7841n54 CNV loss 21841781
dgv7842n54 CNV gain+loss 21841781
dgv7843n54 CNV loss 21841781
esv26806 CNV gain 19812545
esv2723487 CNV deletion 23290073
esv2723488 CNV deletion 23290073
esv2723489 CNV deletion 23290073
esv275165 CNV loss 21479260
esv3647063 CNV gain 21293372
esv3647064 CNV gain 21293372
esv3893416 CNV gain 25118596
nsv1071755 CNV deletion 25765185
nsv1112801 CNV deletion 24896259
nsv1144003 CNV deletion 24896259
nsv459261 CNV loss 19166990
nsv511631 CNV gain 21212237
nsv587496 CNV loss 21841781
nsv587503 CNV loss 21841781
nsv587506 CNV gain+loss 21841781
nsv587509 CNV gain+loss 21841781
nsv587517 CNV gain 21841781
nsv587523 CNV gain+loss 21841781
nsv587528 CNV loss 21841781
nsv587539 CNV loss 21841781
nsv587540 CNV loss 21841781
nsv834102 CNV loss 17160897
nsv953628 CNV deletion 24416366

Variation tolerance for TMPRSS2 Gene

Residual Variation Intolerance Score: 41.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.13; 95.13% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMPRSS2 Gene

Human Gene Mutation Database (HGMD)
TMPRSS2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMPRSS2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMPRSS2 Gene

Disorders for TMPRSS2 Gene

MalaCards: The human disease database

(11) MalaCards diseases for TMPRSS2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
prostatic acinar adenocarcinoma
  • acinar prostate adenocarcinoma
prostate cancer 1
  • prostate cancer, hereditary, 1
influenza
  • flu
male reproductive organ cancer
  • male genital cancer
prostate cancer
  • prostate cancer, hereditary, 5
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TMPRSS2

Genetic Association Database (GAD)
TMPRSS2
Human Genome Epidemiology (HuGE) Navigator
TMPRSS2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMPRSS2
genes like me logo Genes that share disorders with TMPRSS2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TMPRSS2 Gene

Publications for TMPRSS2 Gene

  1. Cloning of the TMPRSS2 gene, which encodes a novel serine protease with transmembrane, LDLRA, and SRCR domains and maps to 21q22.3. (PMID: 9325052) Paoloni-Giacobino A. … Antonarakis S.E. (Genomics 1997) 2 3 4 22 64
  2. TMPRSS2, a serine protease expressed in the prostate on the apical surface of luminal epithelial cells and released into semen in prostasomes, is misregulated in prostate cancer cells. (PMID: 20382709) Chen Y.W. … Lin C.Y. (Am. J. Pathol. 2010) 3 4 22 64
  3. Met160Val polymorphism in the TRMPSS2 gene and risk of prostate cancer in a population-based case-control study. (PMID: 15065083) Lubieniecka J.M. … Ostrander E.A. (Prostate 2004) 3 22 46 64
  4. Expression of transmembrane serine protease TMPRSS2 in mouse and human tissues. (PMID: 11169526) Vaarala M.H. … Vihko P.T. (J. Pathol. 2001) 3 4 22 64
  5. TMPRSS2 and ADAM17 Cleave ACE2 Differentially and Only Proteolysis by TMPRSS2 Augments Entry Driven by the Severe Acute Respiratory Syndrome Coronavirus Spike Protein. (PMID: 24227843) Heurich A. … PAPhlmann S. (J. Virol. 2014) 3 4 64

Products for TMPRSS2 Gene

Sources for TMPRSS2 Gene

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