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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TMPRSS2 Gene

protein-coding GIFtS: 64
GCID: GC21M042836

transmembrane protease, serine 2

Explore 13 diseases affiliated with
TMPRSS2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, and/or ¹¹Nature:405,311-319 and CroW21)
About This Section

Aliases
Transmembrane Protease, Serine 2¹ ²		Epitheliasin¹
PRSS10¹ ² ³		Transmembrane Protease Serine 2²
Serine Protease 10² ³		EC 3.4.21.-³
Transmembrane Protease, Serine 2, EC 3.4.2111		EC 3.4.21⁸
PP9284²		EC 3.4.21.109⁸

External Ids:	HGNC: 11876¹	Entrez Gene: 7113²	Ensembl: ENSG00000184012⁷	OMIM: 602060⁵	UniProtKB: O15393³

Export aliases for TMPRSS2 gene to outside databases

Previous GC identifers: GC21M039410 GC21M041757 GC21M041756 GC21M041750 GC21M028305

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TMPRSS2:

This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a type II

transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain.

Serine proteases are known to be involved in many physiological and pathological processes. This gene was demonstrated

to be up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate

cancer tissue. The protease domain of this protein is thought to be cleaved and secreted into cell media after

autocleavage. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

(provided by RefSeq, Sep 2008)

Gene Wiki entry for TMPRSS2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
About This Section

RefSeq DNA sequence:

NC_000021.8 NC_018932.1 NT_011512.11

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TMPRSS2 gene promoter:
Bach1 SREBP-1c RelA SREBP-1b Ik-2 STAT3 NF-Y Ik-1 CBF(2)
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TMPRSS2 promoter sequence

Search SABiosciences Chromatin IP Primers for TMPRSS2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMPRSS2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.3 Ensembl cytogenetic band: 21q22.3 HGNC cytogenetic band: 21q22.3
Nature(405: 311-319) cytogenetic band: 21q22.3

TMPRSS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMPRSS2 gene location

GeneLoc information about chromosome 21 GeneLoc Exon Structure

(about GC identifiers)

GC21M042836:	GeneLoc	Nature:405,311-319
Start:	42,836,478 bp from pter	28,410,553 bp from centromere
End:	42,903,043 bp from pter	28,443,714 bp from centromere
Size:	66,566 bases	33,162 bases
Orientation:	minus strand	minus strand

Whole chromosome sequencing:
cDNA sequence:	U75329
genomic clones:	Q87D5 to CIT2533B8

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TMPS2_HUMAN, O15393 (See protein sequence)

Recommended Name: Transmembrane protease serine 2 precursor

Size: 492 amino acids; 53859 Da

Subcellular location: Cell membrane; Single-pass type II membrane protein

Subcellular location: Transmembrane protease serine 2 catalytic chain: Secreted. Note=Activated by cleavage and

secreted

Secondary accessions: A8K6Z8 B2R8E5 B7Z459 D3DSJ2 F8WES1 Q6GTK7 Q9BXX1

Alternative splicing: 2 isoforms: O15393-1 O15393-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TMPRSS2: NX_O15393

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O15393

4/6 DME Specific Peptides for TMPRSS2 (O15393) (see all 6)

GDSGGPL

WPWQVSL

CWISGWG

CQGDSGGP

TMPRSS2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001128571.1 NP_005647.3

ENSEMBL proteins:

ENSP00000330330 ENSP00000391216 ENSP00000389006 ENSP00000397846 ENSP00000391784

ENSP00000381588

Human Recombinant Protein Products for TMPRSS2:

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	Novus Biologicals TMPRSS2 Proteins Novus Biologicals TMPRSS2 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for TMPRSS2

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005737	cytoplasm	IDA	--
GO:0005886	plasma membrane	IDA	--
GO:0005887	integral to plasma membrane	TAS	9325052
GO:0016020	membrane	--	--

TMPRSS2 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for TMPRSS2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TMPRSS2 for domains About GeneDecksing

5/8 InterPro domains/families (see all 8):

IPR002172 LDrepeatLR_classA_rpt

IPR001314 Peptidase_S1A

IPR001190 Srcr_rcpt

IPR023415 LDLR_class-A_CS

IPR009003 Trypsin-like_Pept_dom

Graphical View of Domain Structure for InterPro Entry O15393

ProtoNet protein and cluster: O15393

4 Blocks protein families:

IPB001190 Speract/scavenger receptor

IPB001254 Serine protease

IPB001314 Chymotrypsin serine protease family (S1) signature

IPB002172 Low density lipoprotein-receptor

UniProtKB/Swiss-Prot: TMPS2_HUMAN, O15393

Similarity: Belongs to the peptidase S1 family

Similarity: Contains 1 LDL-receptor class A domain

Similarity: Contains 1 peptidase S1 domain

Similarity: Contains 1 SRCR domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

Genatlas biochemistry entry for TMPRSS2:

transmembrane protein,type II,strongly expressed in small intestine and in normal or carcinoid cells of epithelial

prostate,homologous to the enteropeptidase gene,potentially involved in prostate carcinogenesis

Enzyme Numbers (IUBMB): EC 3.4.21² EC 3.4.21.109² EC 3.4.21.-¹

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004252	serine-type endopeptidase activity	IEA	--
GO:0005044	scavenger receptor activity	IEA	--
GO:0008236	serine-type peptidase activity	TAS	9325052

TMPRSS2 for ontologies About GeneDecksing

Phenotypes:
1 MGI mutant phenotype (inferred from 2 alleles) (MGI details for Tmprss2):

normal

TMPRSS2 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-outs for TMPRSS2: Tmprss2^tm1Lex Tmprss2^tm1Tsyk

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for TMPRSS2

miRNA Products:		OriGene 3'-UTR Clone (see all 2): TMPRSS2 Browse MicroRNA Expression Plasmids
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		8/19 QIAGEN miScript miRNA Assays for microRNAs that regulate TMPRSS2 (see all 19):
		hsa-let-7d hsa-miR-202 hsa-let-7c hsa-miR-513c hsa-let-7g hsa-let-7a hsa-miR-15b* hsa-miR-1208

		SwitchGear 3'UTR luciferase reporter plasmid: TMPRSS2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMPRSS2

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Coregulation of Androgen receptor activity

Coregulation of Androgen receptor activity

1.00

Regulation of Androgen receptor activity

Regulation of Androgen receptor activity

1.00

Measles

Influenza A

0.35

Pathway sources
See GeneCards unified pathways
Show all pathways

2 BioSystems Pathways for TMPRSS2

	Coregulation of Androgen receptor activity
	Regulation of Androgen receptor activity

1 Kegg Pathway (Kegg details for TMPRSS2):

Influenza A

TMPRSS2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for TMPRSS2

STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

5 Interacting proteins for TMPRSS2 (O15393³ ENSP00000330330⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
AR	P10275³, ENSP00000363822⁴	I2D: score=1 STRING: ENSP00000363822
CREBBP	Q92793³, ENSP00000262367⁴	I2D: score=1 STRING: ENSP00000262367
ERG	P11308³, ENSP00000381891⁴	I2D: score=1 STRING: ENSP00000381891
KDM3A	ENSP00000323659⁴	STRING: ENSP00000323659
POU2F1	ENSP00000271411⁴	STRING: ENSP00000271411

About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006508	proteolysis	IEA	--

TMPRSS2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

TMPRSS2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TMPRSS2
3 Novoseek chemical compound relationships for TMPRSS2 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
rubin	67.9	2	17826676 (1), 17826677 (1)
serine	50.4	25	20382709 (3), 15879706 (2), 9325052 (2), 11745466 (2) (see all 13)
testosterone	44.3	26	20308527 (3), 20147525 (2), 19584279 (2), 20478527 (1) (see all 8)

Search CenterWatch for drugs/clinical trials and news about TMPRSS2 / TMPS2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TMPRSS2 gene (2 alternative transcripts):

NM_001135099.1 NM_005656.3

Unigene Cluster for TMPRSS2:

Transmembrane protease, serine 2

Hs.439309 [show with all ESTs]

Unigene Representative Sequence: NM_001135099

11 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000332149(uc002yzj.3) ENST00000488556 ENST00000458356 ENST00000454499(uc010gos.1)

ENST00000469395 ENST00000424093 ENST00000497881 ENST00000463138 ENST00000455813

ENST00000489201 ENST00000398585(uc010gor.3)

miRNA Products:		OriGene 3'-UTR Clone (see all 2): TMPRSS2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TMPRSS2
		8/19 QIAGEN miScript miRNA Assays for microRNAs that regulate TMPRSS2 (see all 19):
		hsa-let-7d hsa-miR-202 hsa-let-7c hsa-miR-513c hsa-let-7g hsa-let-7a hsa-miR-15b* hsa-miR-1208

		SwitchGear 3'UTR luciferase reporter plasmid: TMPRSS2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMPRSS2
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Additional cDNA sequence:

AF123453.1 AF270487.1 AF329454.1 AK092554.1 AK123948.1 AK222784.1 AK291813.1 AK296860.1

AK313338.1 BC015819.1 BC035623.1 BC051839.1 DQ204771.1 EU090249.1 HM245389.1 HM245390.1

U75329.1

16 DOTS entries:

DT.212263 DT.101982015 DT.100755214 DT.91757425 DT.101982291 DT.86850243 DT.99997274 DT.101972563

DT.100682811 DT.121131591 DT.121131632 DT.101982290 DT.121131617 DT.95273881 DT.121131588 DT.95273880

24/153 AceView cDNA sequences (see all 153):

BM747154 CK430020 AA904080 BQ083899 AF270487 BX099916 CB156146 BQ082736

BM771081 CB989588 AA515387 BM829557 BE857738 AI668954 AW025029 AI261741

BX479218 AW860347 AW515160 AF329454 BX508867 CF145832 BG485061 T48536

GeneLoc Exon Structure

5/11 Alternative Splicing Database (ASD) splice patterns (SP) for TMPRSS2 (see all 11) About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4a	·	4b	·	4c	^	5	^	6	^	7a	·	7b	^	8	^	9a	·	9b	^	10a	·	10b	·	10c	^	11	^	12	^	13	^	14	^	15	^	16a	·	16b	·	16c	^	17a	·
SP1:					-		-		-		-		-		-																														-						-
SP2:									-		-		-		-
SP3:
SP4:																									-		-
SP5:					-		-		-		-		-		-										-		-

ExUns:	17b	·	17c	^	18a	·	18b	·	18c
SP1:			-
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for TMPRSS2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TMPRSS2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAAATAAATT

About this image

TMPRSS2 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Kidney

Renal Collecting Duct System

Kidney

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Alveolar type II cells (Derivation of mature...)

Lung

See TMPRSS2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TMPRSS2

SOURCE GeneReport for Unigene cluster: Hs.439309

UniProtKB/Swiss-Prot: TMPS2_HUMAN, O15393

Tissue specificity: Expressed strongly in small intestine. Also expressed in prostate, colon, stomach and salivary

gland

SABiosciences Expression via Pathway-Focused PCR Array including TMPRSS2:

Prostate Cancer in human mouse rat

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMPRSS2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMPRSS2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for TMPRSS2 gene from 4/15 species (see all 15) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	TMPRSS2¹	transmembrane protease, serine 2	62.4(n) 60.38(a)		418528 XM_416737.3 XP_416737.2
lizard (Anolis carolinensis)	Reptilia	TMPRSS2⁶	--	58(a)	1 ↔ 1	3(138405613-138424927)
African clawed frog (Xenopus laevis)	Amphibia	Xesp-2²	embryonic serine protease-2	75.58(n)		AB038497.1
zebrafish (Danio rerio)	Actinopterygii	tmprss2¹	transmembrane protease, serine 2	52.98(n) 47.9(a)		494080 NM_001008623.1 NP_001008623.1

ENSEMBL Gene Tree for TMPRSS2 (if available)
TreeFam Gene Tree for TMPRSS2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for TMPRSS2 gene

TMPRSS7² TMPRSS5² ST14² TMPRSS4² TMPRSS11D² TMPRSS13² TMPRSS11E² TMPRSS3²

TMPRSS11B² TMPRSS9² HPN² TMPRSS15² TMPRSS11F² TMPRSS11A² TMPRSS6²

18/78 SIMAP similar genes for TMPRSS2 using alignment to 5 protein entries: TMPS2_HUMAN (see all proteins) (see all similar genes):

MGC52282 DESC1 PRSS46 TMPRSS11B TMPRSS11E PROC1

TMPRSS11A TMPRSS11F PROC CELA2B PRSS42 TMPRSS11D

TMPRSS3 DKFZp586F0824 TMPRSS12 KLKB1 PRSS22 PRSS1

TMPRSS2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 21 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs11088550^1,2		--	42835994(+)	`TGGGAA/GGGACC`	2	--	ds500¹		0	--	--	--	--
rs144157441^1,2		--	42836039(+)	`TTCCTA/GTGCTG`	2	--	ds500¹		0	--	--	--	--
rs147349930^1,2		--	42836120(+)	`TCTCCC/TTGCCT`	2	--	ds500¹		0	--	--	--	--
rs181874957^1,2		--	42836127(+)	`GCCTGC/TTGCCA`	2	--	ds500¹		0	--	--	--	--
rs186484871^1,2		--	42836137(+)	`ATCCAC/TGTAAG`	2	--	ds500¹		0	--	--	--	--
rs191368876^1,2		--	42836149(+)	`TGTGAC/TTTGCT`	2	--	ds500¹		0	--	--	--	--
rs463727^1,2	C,F,A,H	--	42836186(+)	`aggccT/Acccca`	2	--	ds500¹		5		NA CSA	10
rs8129769^1,2	H	--	42836344(+)	`CTGAGG/AGCACC`	2	--	ds500¹		4		NS EA	420
rs181162134^1,2		--	42836475(+)	`TGCAGC/TAGTTA`	2	--	ds500¹		0	--	--	--	--
rs462471^1,2	C,F,A,H	--	42836476(+)	`GCAGTG/AGTTAC`	2	--	ds500¹		25		NA NS EA CSA WA	2213

HapMap Linkage Disequilibrium report for TMPRSS2 (42836478 - 42903043 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for TMPRSS2
1 CNV: 73640

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TMPRSS2 for disorders           About GeneDecksing

OMIM gene information: 602060    OMIM disorders: --

13 diseases for TMPRSS2:    About MalaCards

prostate cancer prostatitis small cell carcinoma prostate small cell carcinoma

hearing loss familial prostate cancer prostate cancer, progression of prostate carcinoma

gout prostate adenocarcinoma carcinoma influenza

adenocarcinoma

1 disease from the University of Copenhagen DISEASES database for TMPRSS2:

Prostate cancer

7 Novoseek disease relationships for TMPRSS2 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
prostate cancer	80.6	164	17334343 (6), 18519769 (6), 18500259 (6), 17172822 (5) (see all 64)
prostate carcinoma	44.9	4	19465903 (3), 19642730 (1)
cancer	37.5	10	18338334 (2), 17079440 (1), 19242826 (1), 11745466 (1) (see all 8)
tumors	33.6	26	19597533 (2), 19242826 (2), 19494719 (2), 18500259 (2) (see all 14)
carcinoma	33.1	2	18550704 (1), 19465903 (1)
metastasis	11.6	6	18338334 (2), 18385909 (2)
chromosomal aberrations	9.84	1	17334343 (1)

Genetic Association Database (GAD): TMPRSS2
Human Genome Epidemiology (HuGE) Navigator: TMPRSS2 (4 documents)

Export disorders for TMPRSS2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for TMPRSS2 gene, integrated from 9 sources (see all 156):
(articles sorted by number of sources associating them with TMPRSS2)

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Cloning of the TMPRSS2 gene, which encodes a novel serine protease with transmembrane, LDLRA, and SRCR domains and maps to 21q22.3. (PubMed id 9325052)^{1, 2, 3, 9} Paoloni-Giacobino A....Antonarakis S.E. (1997)
Expression of transmembrane serine protease TMPRSS2 in mouse and human tissues. (PubMed id 11169526)^{1, 2, 9} Vaarala M.H.... Vihko P.T. (2001)
Met160Val polymorphism in the TRMPSS2 gene and risk of prostate cancer in a population-based case-control study. (PubMed id 15065083)^{1, 4, 9} Lubieniecka J.M....Ostrander E.A. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Catalytic cleavage of the androgen-regulated TMPRSS2 protease results in its secretion by prostate and prostate cancer epithelia. (PubMed id 11245484)^{1, 2} Afar D.E.H.... Jakobovits A. (2001)
Mutation analyses of 268 candidate genes in human tumor cell lines. (PubMed id 11414763)^{1, 2} Teng D.-H.... Wong A.K.C. (2001)
The DNA sequence of human chromosome 21. (PubMed id 10830953)^{1, 2} Hattori M....Yaspo M.L. (2000)
Detection of TMPRSS2:ERG fusion gene in circulating prostate cancer cells. (PubMed id 18385909)^{1, 9} Mao X....Lu Y.J. (2008)
Quantitative expression of TMPRSS2 transcript in pros tate tumor cells reflects TMPRSS2-ERG fusion status. (PubMed id 19597533)^{1, 9} Mwamukonda K....Petrovics G. (2010)
TMPRSS2, a serine protease expressed in the prostate on the apical surface of luminal epithelial cells and released into semen in pr ostasomes, is misregulated in prostate cancer cells. (PubMed id 20382709)^{1, 9} Chen Y.W....Lin C.Y. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 7113	HGNC: 11876	AceView: TMPRSS2	Ensembl:ENSG00000184012	euGenes: HUgn7113
ECgene: TMPRSS2	Kegg: 7113	H-InvDB: TMPRSS2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for TMPRSS2	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for TMPRSS2	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for TMPRSS2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for TMPRSS2 gene:
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transmembrane protease, serine 2

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transmembrane protease, serine 2

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