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TMPRSS15 Gene

protein-coding   GIFtS: 53
GCID: GC21M019641

Transmembrane Protease, Serine 15

(Previous names: protease, serine, 7 (enterokinase))
(Previous symbol: PRSS7)
  See TMPRSS15-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Transmembrane Protease, Serine 151 2     EC 3.4.21.93 8
PRSS71 2 3 5     proenterokinase1
ENTK2 3 5     Enterokinase Catalytic Subunit2
Protease, Serine, 7 (Enterokinase)1 2     Enterokinase3
enteropeptidase1 2     Transmembrane Protease Serine 153
Serine Protease 72 3     EC 3.4.218

External Ids:    HGNC: 94901   Entrez Gene: 56512   Ensembl: ENSG000001546467   OMIM: 6066355   UniProtKB: P980733   

Export aliases for TMPRSS15 gene to outside databases

Previous GC identifer: GC21M005029


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TMPRSS15 Gene:
This gene encodes an enzyme that converts the pancreatic proenzyme trypsinogen to trypsin, which activates other
proenzymes including chymotrypsinogen and procarboxypeptidases. The precursor protein is cleaved into two chains
that form a heterodimer linked by a disulfide bond. This protein is a member of the trypsin family of peptidases.
Mutations in this gene cause enterokinase deficiency, a malabsorption disorder characterized by diarrhea and
failure to thrive. (provided by RefSeq, Jul 2008)

GeneCards Summary for TMPRSS15 Gene:
TMPRSS15 (transmembrane protease, serine 15) is a protein-coding gene. Diseases associated with TMPRSS15 include enterokinase deficiency, and hymenolepiasis. GO annotations related to this gene include scavenger receptor activity and serine-type endopeptidase activity. An important paralog of this gene is TMPRSS11D.

UniProtKB/Swiss-Prot: ENTK_HUMAN, P98073
Function: Responsible for initiating activation of pancreatic proteolytic proenzymes (trypsin, chymotrypsin and
carboxypeptidase A). It catalyzes the conversion of trypsinogen to trypsin which in turn activates other
proenzymes including chymotrypsinogen, procarboxypeptidases, and proelastases




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000021.8  NC_018932.2  NT_011512.12  
Regulatory elements:
   Search for regulatory transcription factor binding sites for TMPRSS15
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMPRSS15 promoter sequence
   Search Chromatin IP Primers for TMPRSS15

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TMPRSS15


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q21.1   Ensembl cytogenetic band:  21q21.1   HGNC cytogenetic band: 21q21

TMPRSS15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMPRSS15 gene location

GeneLoc information about chromosome 21         GeneLoc Exon Structure

GeneLoc location for GC21M019641:  view genomic region     (about GC identifiers)

Start:
19,641,433 bp from pter      End:
19,858,197 bp from pter
Size:
216,765 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ENTK_HUMAN, P98073 (See protein sequence)
Recommended Name: Enteropeptidase precursor  
Size: 1019 amino acids; 112935 Da
Subunit: Heterodimer of a catalytic (light) chain and a multidomain (heavy) chain linked by a disulfide bond
Sequence caution: Sequence=CAB90389.1; Type=Erroneous gene model prediction;
1 PDB 3D structure from and Proteopedia for TMPRSS15:
4DGJ (3D)    
Secondary accessions: Q2NKL7

Explore the universe of human proteins at neXtProt for TMPRSS15: NX_P98073

Explore proteomics data for TMPRSS15 at MOPED

Post-translational modifications: 

  • The chains are derived from a single precursor that is cleaved by a trypsin-like protease1
  • Glycosylation2 at Asn116, Asn147, Asn179, Asn328, Asn335, Asn388, Asn440, Asn470, Asn503, Asn534,
                                 Asn630, Asn682, Asn706, Asn725, Asn848, Asn887, Asn909, Asn949
  • Selected DME Specific Peptides for TMPRSS15 (P98073) (see all 12)
     CPDGSDE  SNLTSPQ  GDSGGPL  PEYNITE 


    See TMPRSS15 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002763.2  
    ENSEMBL proteins: 
     ENSP00000284885   ENSP00000398253   ENSP00000474811  

    TMPRSS15 Human Recombinant Protein Products:

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    Novus Biologicals TMPRSS15 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for TMPRSS15
    Browse Proteins at Cloud-Clone Corp.

     
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    antibodies-online proteins for TMPRSS15 (40 products) 

     
    antibodies-online peptides for TMPRSS15

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TMPRSS: Serine peptidases / Transmembrane

    Selected InterPro protein domains (see all 12):
     IPR000859 CUB_dom
     IPR002172 LDrepeatLR_classA_rpt
     IPR001314 Peptidase_S1A
     IPR001190 SRCR
     IPR023415 LDLR_class-A_CS

    Graphical View of Domain Structure for InterPro Entry P98073

    ProtoNet protein and cluster: P98073

    Selected Blocks protein domains (see all 7):
    IPB000082 SEA domain
    IPB000859 CUB domain
    IPB000998 MAM domain signature
    IPB001190 Speract/scavenger receptor
    IPB001254 Serine protease


    UniProtKB/Swiss-Prot: ENTK_HUMAN, P98073
    Similarity: Belongs to the peptidase S1 family
    Similarity: Contains 2 CUB domains
    Similarity: Contains 2 LDL-receptor class A domains
    Similarity: Contains 1 MAM domain
    Similarity: Contains 1 peptidase S1 domain
    Similarity: Contains 1 SEA domain
    Similarity: Contains 1 SRCR domain


    Find genes that share domains with TMPRSS15           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ENTK_HUMAN, P98073
    Function: Responsible for initiating activation of pancreatic proteolytic proenzymes (trypsin, chymotrypsin and
    carboxypeptidase A). It catalyzes the conversion of trypsinogen to trypsin which in turn activates other
    proenzymes including chymotrypsinogen, procarboxypeptidases, and proelastases
    Catalytic activity: Activation of trypsinogen by selective cleavage of 6-Lys- -Ile-7 bond

         Enzyme Numbers (IUBMB): EC 3.4.21.91 2 EC 3.4.212

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004252serine-type endopeptidase activity IEA--
    GO:0005044scavenger receptor activity IEA--
    GO:0005515protein binding ----
         
    Find genes that share ontologies with TMPRSS15           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for TMPRSS15:
     Increased mitotic index 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Tmprss15):
     homeostasis/metabolism 

    Find genes that share phenotypes with TMPRSS15           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for TMPRSS15

    miRNA
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    3 qRT-PCR Assays for microRNAs that regulate TMPRSS15:
    hsa-miR-579 hsa-miR-466 hsa-miR-664
    SwitchGear 3'UTR luciferase reporter plasmidTMPRSS15 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ENTK_HUMAN, P98073: Membrane; Single-pass type II membrane protein (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    extracellular2
    golgi apparatus2
    cytosol1
    endoplasmic reticulum1
    lysosome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005903brush border TAS8052624
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with TMPRSS15           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TMPRSS15
    Interactions:

        Search GeneGlobe Interaction Network for TMPRSS15

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for TMPRSS15 (P980733 ENSP000002848854) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SPINK1P009953, ENSP000002966954I2D: score=1 STRING: ENSP00000296695
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis ----

    Find genes that share ontologies with TMPRSS15           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TMPRSS15 (ENTK)

    Selected Novoseek inferred chemical compound relationships for TMPRSS15 gene (see all 19)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    trypsinogen 92.2 62 15970597 (4), 7547882 (2), 7503430 (2), 7718557 (2) (see all 34)
    imac 66 3 10486130 (1), 10201111 (1), 10194406 (1)
    chymotrypsinogen 63.9 2 16797260 (1), 8511507 (1)
    hbd2 60.6 2 16599550 (1), 17177327 (1)
    serine 56.7 20 19566868 (2), 7718557 (2), 19482641 (2), 17097793 (1) (see all 13)
    iptg 56.3 1 11751393 (1)
    histidine 52.8 9 10486130 (1), 10649231 (1), 11753928 (1), 10201111 (1) (see all 9)
    aprotinin 35.4 1 17623652 (1)
    taurocholate 19.1 2 12371983 (1), 11445702 (1)
    nad+ 4.12 1 10933785 (1)



    Find genes that share compounds with TMPRSS15           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TMPRSS15 gene: 
    NM_002772.2  

    Unigene Cluster for TMPRSS15:

    Transmembrane protease, serine 15
    Hs.149473  [show with all ESTs]
    Unigene Representative Sequence: NM_002772
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000284885(uc002ykw.3) ENST00000422787 ENST00000474775
    miRNA
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    3 qRT-PCR Assays for microRNAs that regulate TMPRSS15:
    hsa-miR-579 hsa-miR-466 hsa-miR-664
    SwitchGear 3'UTR luciferase reporter plasmidTMPRSS15 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat TMPRSS15

    Additional mRNA sequence: 

    BC111749.1 U09860.1 

    1 DOTS entry:

    DT.40106363 

    13 AceView cDNA sequences:

    U09860 NM_002772 BF244418 BX283646 BF244497 BM015908 BG574802 BE737932 
    AI279666 BF687527 BF215992 BF219079 BU431045 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TMPRSS15 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAATTAAGT
    TMPRSS15 Expression
    About this image


    TMPRSS15 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Kidney (Urinary System)
             Metanephros
     
     Brain (Nervous System)
             Cerebral Cortex
    TMPRSS15 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TMPRSS15 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.149473

    UniProtKB/Swiss-Prot: ENTK_HUMAN, P98073
    Tissue specificity: Intestinal brush border

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TMPRSS15 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tmprss151 , 5 transmembrane protease, serine 151, 5 80.21(n)1
    75.17(a)1
      16 (45.41 cM)5
    191461  NM_178855.41  NP_849186.21 
     789530085 
    chicken
    (Gallus gallus)
    Aves TMPRSS151 transmembrane protease, serine 15 65.71(n)
    57(a)
      427967  XM_425539.4  XP_425539.4 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia tmprss151 transmembrane protease, serine 15 63.73(n)
    57.59(a)
      100490249  XM_002933084.2  XP_002933130.2 
    zebrafish
    (Danio rerio)
    Actinopterygii tmprss151 transmembrane protease, serine 15 54.97(n)
    48.41(a)
      100148042  XM_001919604.2  XP_001919639.2 


    ENSEMBL Gene Tree for TMPRSS15 (if available)
    TreeFam Gene Tree for TMPRSS15 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TMPRSS15 gene
    TMPRSS11D2  TMPRSS32  TMPRSS11B2  TMPRSS62  TMPRSS11A2  TMPRSS72  TMPRSS52  TMPRSS42  
    ST142  TMPRSS132  TMPRSS11E2  TMPRSS22  KLKB12  F112  HPN2  TMPRSS11F2  
    Selected SIMAP similar genes for TMPRSS15 using alignment to 2 protein entries:     ENTK_HUMAN (see all proteins) (see all similar genes):
    PRSS7    KLK13    PRSS1    DKFZp586F0824    TMPRSS11F    CELA2B
    DKFZp779M0222    TMPRSS11A    F9    CTRB2    GZMK    HP
    NRP1    PRSS22    CTRB1    CTRL    DESC1    TMPRSS11D

    Find genes that share paralogs with TMPRSS15           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TMPRSS15 (see all 3136)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 21 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs772006261,2
    C,Fpathogenic110239672(+) CATTTG/CAAATC 2 /S /* stg12Minor allele frequency- C:0.00NA 4670
    rs1841066791,2
    --5029102(+) GCATTC/TGTCCA 1 -- ds50010--------
    rs81278781,2
    C,F--5029103(+) CATTCG/ATCCAT 1 -- ds50012Minor allele frequency- A:0.10WA 120
    rs1995879451,2
    C--5029105(+) TCGTC-/CATCATCA 1 -- cds10--------
    rs1880653341,2
    --5029122(+) CACACC/TTTCTT 1 -- ds50010--------
    rs110886721,2
    C,F,A,H--5029232(+) ACAGTA/GGATCC 1 -- ds500124Minor allele frequency- G:0.21NS EA NA WA CSA 2658
    rs15698351,2
    C,F,O,A,H--5029301(-) TGGAAT/GAAAGG 1 -- ds500117Minor allele frequency- G:0.21NS EA WA NA CSA 2222
    rs1412469111,2
    C--5029357(+) CCTTA-/CTCT  
            
    CTCTC
    1 -- ds50010--------
    rs347339911,2
    C--5029365(+) TCTCT-/C/CTCT
            
    TCTAT
    1 -- ds50010--------
    rs1807401761,2
    --5029412(+) GGTGCA/GTATGT 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for TMPRSS15 (19641433 - 19858197 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for TMPRSS15 (see all 15):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2723212CNV Deletion23290073
    esv1470738CNV Deletion17803354
    esv2657867CNV Deletion23128226
    esv1003839CNV Deletion20482838
    nsv187307CNV Insertion16902084
    nsv3470CNV Insertion18451855
    nsv522760CNV Loss19592680
    nsv518906CNV Loss19592680
    nsv913433CNV Loss21882294
    nsv913434CNV Loss21882294

    Human Gene Mutation Database (HGMD): TMPRSS15
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TMPRSS15
    DNA2.0 Custom Variant and Variant Library Synthesis for TMPRSS15

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606635   
    OMIM disorders: 226200  
    UniProtKB/Swiss-Prot: ENTK_HUMAN, P98073
  • Enterokinase deficiency (ENTKD) [MIM:226200]: Life-threatening intestinal malabsorption disorder
    characterized by diarrhea and failure to thrive. Note=The disease is caused by mutations affecting the gene
    represented in this entry

  • 6 diseases for TMPRSS15:    
    About MalaCards
    enterokinase deficiency    hymenolepiasis    diarrhea    hereditary pancreatitis
    steatorrhea    pancreatitis

    2 diseases from the University of Copenhagen DISEASES database for TMPRSS15:
    Pancreatitis     Hymenolepiasis

    Find genes that share disorders with TMPRSS15           About GenesLikeMe

    Selected Novoseek inferred disease relationships for TMPRSS15 gene (see all 13)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    enteropeptidase deficiency 94.6 9 11719902 (4), 8208733 (2), 11467662 (2), 9645159 (1)
    pancreatitis 49.1 5 12371983 (1), 11445702 (1), 10691375 (1), 10722028 (1)
    steatorrhea 38.4 1 8208733 (1)
    chronic pancreatitis 36.4 3 10722028 (1), 2068865 (1), 19482641 (1)
    acute pancreatitis 35.5 1 8208733 (1)
    pancreatic diseases 22.5 1 2068865 (1)
    reflux 17.9 5 8208733 (1), 19734625 (1), 20007078 (1), 10722028 (1) (see all 5)
    carcinoma squamous cell 0 1 18062964 (1)
    necrosis 0 1 9706704 (1)
    gastric cancer 0 1 10348909 (1)

    Genetic Association Database (GAD): TMPRSS15
    Human Genome Epidemiology (HuGE) Navigator: TMPRSS15 (0 documents)

    Export disorders for TMPRSS15 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TMPRSS15 gene, integrated from 10 sources (see all 159):
    (articles sorted by number of sources associating them with TMPRSS15)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Enterokinase, the initiator of intestinal digestion, is a mosaic protease composed of a distinctive assortment of domains. (PubMed id 8052624)1, 2, 3, 9 Kitamoto Y.... Sadler J.E. (Proc. Natl. Acad. Sci. U.S.A. 1994)
    2. Mutations in the proenteropeptidase gene are the molecular cause of congenital enteropeptidase deficiency. (PubMed id 11719902)1, 2, 9 Holzinger A.... Roscher A.A. (Am. J. Hum. Genet. 2002)
    3. cDNA sequence and chromosomal localization of human enterokinase, the proteolytic activator of trypsinogen. (PubMed id 7718557)1, 2, 9 Kitamoto Y.... Sadler J.E. (Biochemistry 1995)
    4. Crystal structure of a supercharged variant of the human enteropeptidase light chain. (PubMed id 22488687)1, 2 Simeonov P.... Zuchner T. (Proteins 2012)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. The DNA sequence of human chromosome 21. (PubMed id 10830953)1, 2 Hattori M.... Yaspo M.-L. (Nature 2000)
    7. Intracellular co-localization of trypsin-2 and matrix metalloprotease-9: possible proteolytic cascade of trypsin-2, MMP-9 and enterokinase in carcinoma. (PubMed id 18062964)1, 9 Vilen S.T....Salo T. (Exp. Cell Res. 2008)
    8. Keratinocytes synthesize enteropeptidase and multiple forms of trypsinogen during terminal differentiation. (PubMed id 19924134)1, 9 Nakanishi J.... Hibino T. (J. Invest. Dermatol. 2010)
    9. Expression of enteropeptidase in differentiated enterocytes, goblet cells, and the tumor cells in human duodenum. (PubMed id 12907431)1, 9 Imamura T. and Kitamoto Y. (Am. J. Physiol. Gastrointest. Liver Physiol. 2003)
    10. Human enteropeptidase light chain: bioengineering of recombinants and kinetic investigations of structure and function. (PubMed id 23436726)1 Smith E.T. and Johnson D.A. (Protein Sci. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5651 HGNC: 9490 AceView: PRSS7 Ensembl:ENSG00000154646 euGenes: HUgn5651
    ECgene: TMPRSS15 H-InvDB: TMPRSS15

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TMPRSS15 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TMPRSS15 gene:
    Search GeneIP for patents involving TMPRSS15

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    Advanced Cell Diagnostics, Animal models from genOway)
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