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Aliases for TMPRSS15 Gene

Aliases for TMPRSS15 Gene

  • Transmembrane Protease, Serine 15 2 3 5
  • Protease, Serine, 7 (Enterokinase) 2 3
  • Serine Protease 7 3 4
  • EC 3.4.21.9 4 63
  • PRSS7 3 4
  • ENTK 3 4
  • Transmembrane Protease Serine 15 4
  • Enterokinase Catalytic Subunit 3
  • Proenterokinase 2
  • Enteropeptidase 2
  • Enterokinase 4
  • EC 3.4.21 63

External Ids for TMPRSS15 Gene

Previous HGNC Symbols for TMPRSS15 Gene

  • PRSS7

Previous GeneCards Identifiers for TMPRSS15 Gene

  • GC21M019641
  • GC21M005029

Summaries for TMPRSS15 Gene

Entrez Gene Summary for TMPRSS15 Gene

  • This gene encodes an enzyme that converts the pancreatic proenzyme trypsinogen to trypsin, which activates other proenzymes including chymotrypsinogen and procarboxypeptidases. The precursor protein is cleaved into two chains that form a heterodimer linked by a disulfide bond. This protein is a member of the trypsin family of peptidases. Mutations in this gene cause enterokinase deficiency, a malabsorption disorder characterized by diarrhea and failure to thrive. [provided by RefSeq, Jul 2008]

GeneCards Summary for TMPRSS15 Gene

TMPRSS15 (Transmembrane Protease, Serine 15) is a Protein Coding gene. Diseases associated with TMPRSS15 include Enterokinase Deficiency and Congenital Enteropathy Due To Enteropeptidase Deficiency. GO annotations related to this gene include serine-type endopeptidase activity and scavenger receptor activity. An important paralog of this gene is TMPRSS11A.

UniProtKB/Swiss-Prot for TMPRSS15 Gene

  • Responsible for initiating activation of pancreatic proteolytic proenzymes (trypsin, chymotrypsin and carboxypeptidase A). It catalyzes the conversion of trypsinogen to trypsin which in turn activates other proenzymes including chymotrypsinogen, procarboxypeptidases, and proelastases.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMPRSS15 Gene

Genomics for TMPRSS15 Gene

Regulatory Elements for TMPRSS15 Gene

Enhancers for TMPRSS15 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TMPRSS15 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMPRSS15 Gene

Chromosome:
21
Start:
18,269,107 bp from pter
End:
18,485,879 bp from pter
Size:
216,773 bases
Orientation:
Minus strand

Genomic View for TMPRSS15 Gene

Genes around TMPRSS15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMPRSS15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMPRSS15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMPRSS15 Gene

Proteins for TMPRSS15 Gene

  • Protein details for TMPRSS15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P98073-ENTK_HUMAN
    Recommended name:
    Enteropeptidase
    Protein Accession:
    P98073
    Secondary Accessions:
    • Q2NKL7

    Protein attributes for TMPRSS15 Gene

    Size:
    1019 amino acids
    Molecular mass:
    112935 Da
    Quaternary structure:
    • Heterodimer of a catalytic (light) chain and a multidomain (heavy) chain linked by a disulfide bond.
    SequenceCaution:
    • Sequence=CAB90389.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TMPRSS15 Gene

neXtProt entry for TMPRSS15 Gene

Proteomics data for TMPRSS15 Gene at MOPED

Post-translational modifications for TMPRSS15 Gene

  • The chains are derived from a single precursor that is cleaved by a trypsin-like protease.
  • Glycosylation at Asn 116, Asn 147, Asn 179, Asn 328, Asn 335, Asn 388, Asn 440, Asn 470, Asn 503, Asn 534, Asn 630, Asn 682, Asn 706, Asn 725, Asn 848, Asn 887, Asn 909, and Asn 949
  • Modification sites at PhosphoSitePlus

Other Protein References for TMPRSS15 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for TMPRSS15 (Enteropeptidase/Enterokinase)

Domains & Families for TMPRSS15 Gene

Gene Families for TMPRSS15 Gene

Suggested Antigen Peptide Sequences for TMPRSS15 Gene

Graphical View of Domain Structure for InterPro Entry

P98073

UniProtKB/Swiss-Prot:

ENTK_HUMAN :
  • Contains 2 CUB domains.
  • Belongs to the peptidase S1 family.
Domain:
  • Contains 2 CUB domains.
  • Contains 2 LDL-receptor class A domains.
  • Contains 1 MAM domain.
  • Contains 1 peptidase S1 domain.
  • Contains 1 SEA domain.
  • Contains 1 SRCR domain.
Family:
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with TMPRSS15: view

Function for TMPRSS15 Gene

Molecular function for TMPRSS15 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Activation of trypsinogen by selective cleavage of 6-Lys- -Ile-7 bond.
UniProtKB/Swiss-Prot Function:
Responsible for initiating activation of pancreatic proteolytic proenzymes (trypsin, chymotrypsin and carboxypeptidase A). It catalyzes the conversion of trypsinogen to trypsin which in turn activates other proenzymes including chymotrypsinogen, procarboxypeptidases, and proelastases.

Enzyme Numbers (IUBMB) for TMPRSS15 Gene

genes like me logo Genes that share phenotypes with TMPRSS15: view

Human Phenotype Ontology for TMPRSS15 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for TMPRSS15 Gene

MGI Knock Outs for TMPRSS15:

Animal Model Products

No data available for Gene Ontology (GO) - Molecular Function , Transcription Factor Targets and HOMER Transcription for TMPRSS15 Gene

Localization for TMPRSS15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMPRSS15 Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMPRSS15 Gene COMPARTMENTS Subcellular localization image for TMPRSS15 gene
Compartment Confidence
plasma membrane 4
extracellular 3
endoplasmic reticulum 2
golgi apparatus 2
cytosol 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for TMPRSS15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMPRSS15: view

Pathways & Interactions for TMPRSS15 Gene

SuperPathways for TMPRSS15 Gene

No Data Available

Interacting Proteins for TMPRSS15 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000284885%0d%0a9606.ENSP00000465500%0d%0a9606.ENSP00000296695%0d%0a9606.ENSP00000305230%0d%0a
Selected Interacting proteins: ENSP00000284885 P98073-ENTK_HUMAN for TMPRSS15 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for TMPRSS15 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMPRSS15 Gene

Drugs & Compounds for TMPRSS15 Gene

(9) Drugs for TMPRSS15 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(10) Additional Compounds for TMPRSS15 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TMPRSS15: view

Transcripts for TMPRSS15 Gene

mRNA/cDNA for TMPRSS15 Gene

(7) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(13) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMPRSS15 Gene

Transmembrane protease, serine 15:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMPRSS15 Gene

No ASD Table

Relevant External Links for TMPRSS15 Gene

GeneLoc Exon Structure for
TMPRSS15
ECgene alternative splicing isoforms for
TMPRSS15

Expression for TMPRSS15 Gene

mRNA expression in normal human tissues for TMPRSS15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMPRSS15 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x47.3).

Protein differential expression in normal tissues from HIPED for TMPRSS15 Gene

This gene is overexpressed in Pancreatic juice (68.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TMPRSS15 Gene



SOURCE GeneReport for Unigene cluster for TMPRSS15 Gene Hs.149473

mRNA Expression by UniProt/SwissProt for TMPRSS15 Gene

P98073-ENTK_HUMAN
Tissue specificity: Intestinal brush border.
genes like me logo Genes that share expression patterns with TMPRSS15: view

Protein tissue co-expression partners for TMPRSS15 Gene

Primer Products

Orthologs for TMPRSS15 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMPRSS15 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TMPRSS15 35
  • 86.33 (n)
  • 82.53 (a)
TMPRSS15 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMPRSS15 35
  • 88.52 (n)
  • 84.99 (a)
TMPRSS15 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmprss15 35
  • 80.21 (n)
  • 75.17 (a)
Tmprss15 16
Tmprss15 36
  • 72 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TMPRSS15 35
  • 99.18 (n)
  • 98.72 (a)
TMPRSS15 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmprss15 35
  • 78.48 (n)
  • 74.05 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 30 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 37 (a)
ManyToMany
chicken
(Gallus gallus)
Aves TMPRSS15 35
  • 65.71 (n)
  • 57 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tmprss15 35
  • 63.73 (n)
  • 57.59 (a)
zebrafish
(Danio rerio)
Actinopterygii tmprss15 35
  • 54.97 (n)
  • 48.41 (a)
Species with no ortholog for TMPRSS15:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMPRSS15 Gene

ENSEMBL:
Gene Tree for TMPRSS15 (if available)
TreeFam:
Gene Tree for TMPRSS15 (if available)

Paralogs for TMPRSS15 Gene

genes like me logo Genes that share paralogs with TMPRSS15: view

Variants for TMPRSS15 Gene

Sequence variations from dbSNP and Humsavar for TMPRSS15 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
rs2273204 - 18,326,432(-) TTCCA(A/G)GTAGG reference, missense
rs2824804 - 18,398,245(+) AGAGT(C/T)TGTCT reference, missense
rs11088674 - 18,315,200(+) GAGAT(G/T)CACCA reference, missense
rs35987974 - 18,398,281(-) AATAA(C/T)ATCCG reference, missense
rs2824790 - 18,383,723(+) ATTTT(C/G/T)ATCTG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for TMPRSS15 Gene

Variant ID Type Subtype PubMed ID
esv2751925 CNV Loss 17911159
nsv459105 CNV Loss 19166990
nsv819544 CNV Gain 19587683
nsv187307 CNV Insertion 16902084
nsv518906 CNV Loss 19592680
esv1003839 CNV Deletion 20482838
esv1470738 CNV Deletion 17803354
nsv522137 CNV Loss 19592680
nsv913433 CNV Loss 21882294
nsv913434 CNV Loss 21882294
nsv3470 CNV Insertion 18451855
nsv522760 CNV Loss 19592680
nsv459106 CNV Loss 19166990
esv2723212 CNV Deletion 23290073
esv2657867 CNV Deletion 23128226

Variation tolerance for TMPRSS15 Gene

Residual Variation Intolerance Score: 91.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.78; 94.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMPRSS15 Gene

Human Gene Mutation Database (HGMD)
TMPRSS15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMPRSS15 Gene

Disorders for TMPRSS15 Gene

MalaCards: The human disease database

(9) MalaCards diseases for TMPRSS15 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
enterokinase deficiency
  • enteropeptidase deficiency
congenital enteropathy due to enteropeptidase deficiency
  • congenital enterokinase deficiency
hymenolepiasis
  • dwarf tapeworm infection
steatorrhea
  • fatty stool
western equine encephalitis
  • wee
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

ENTK_HUMAN
  • Enterokinase deficiency (ENTKD) [MIM:226200]: Life-threatening intestinal malabsorption disorder characterized by diarrhea and failure to thrive. {ECO:0000269 PubMed:11719902}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for TMPRSS15

Genetic Association Database (GAD)
TMPRSS15
Human Genome Epidemiology (HuGE) Navigator
TMPRSS15
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMPRSS15
genes like me logo Genes that share disorders with TMPRSS15: view

No data available for Genatlas for TMPRSS15 Gene

Publications for TMPRSS15 Gene

  1. Enterokinase, the initiator of intestinal digestion, is a mosaic protease composed of a distinctive assortment of domains. (PMID: 8052624) Kitamoto Y. … Sadler J.E. (Proc. Natl. Acad. Sci. U.S.A. 1994) 2 3 4 23 67
  2. Keratinocytes synthesize enteropeptidase and multiple forms of trypsinogen during terminal differentiation. (PMID: 19924134) Nakanishi J. … Hibino T. (J. Invest. Dermatol. 2010) 3 23
  3. Intracellular co-localization of trypsin-2 and matrix metalloprotease-9: possible proteolytic cascade of trypsin-2, MMP-9 and enterokinase in carcinoma. (PMID: 18062964) Vilen S.T. … Salo T. (Exp. Cell Res. 2008) 3 23
  4. Expression of enteropeptidase in differentiated enterocytes, goblet cells, and the tumor cells in human duodenum. (PMID: 12907431) Imamura T. … Kitamoto Y. (Am. J. Physiol. Gastrointest. Liver Physiol. 2003) 3 23
  5. Mutations in the proenteropeptidase gene are the molecular cause of congenital enteropeptidase deficiency. (PMID: 11719902) Holzinger A. … Roscher A.A. (Am. J. Hum. Genet. 2002) 3 23

Products for TMPRSS15 Gene

Sources for TMPRSS15 Gene

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