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Aliases for TMPRSS15 Gene

Aliases for TMPRSS15 Gene

  • PRSS7 3 4 6
  • ENTK 3 4 6
  • Protease, Serine, 7 (Enterokinase) 2 3
  • Transmembrane Protease, Serine 15 2 3
  • Serine Protease 7 3 4
  • Enteropeptidase 2 3
  • EC 4 64
  • Transmembrane Protease Serine 15 4
  • Enterokinase Catalytic Subunit 3
  • Proenterokinase 2
  • Enterokinase 4
  • EC 3.4.21 64

External Ids for TMPRSS15 Gene

Previous Symbols for TMPRSS15 Gene

  • PRSS7

Summaries for TMPRSS15 Gene

Entrez Gene Summary for TMPRSS15 Gene

  • This gene encodes an enzyme that converts the pancreatic proenzyme trypsinogen to trypsin, which activates other proenzymes including chymotrypsinogen and procarboxypeptidases. The precursor protein is cleaved into two chains that form a heterodimer linked by a disulfide bond. This protein is a member of the trypsin family of peptidases. Mutations in this gene cause enterokinase deficiency, a malabsorption disorder characterized by diarrhea and failure to thrive. [provided by RefSeq, Jul 2008]

GeneCards Summary for TMPRSS15 Gene

TMPRSS15 is a Protein Coding gene. Diseases associated with TMPRSS15 include enterokinase deficiency and congenital enteropathy due to enteropeptidase deficiency. GO annotations related to this gene include serine-type endopeptidase activity and scavenger receptor activity. An important paralog of this gene is HPN.

UniProtKB/Swiss-Prot for TMPRSS15 Gene

  • Responsible for initiating activation of pancreatic proteolytic proenzymes (trypsin, chymotrypsin and carboxypeptidase A). It catalyzes the conversion of trypsinogen to trypsin which in turn activates other proenzymes including chymotrypsinogen, procarboxypeptidases, and proelastases

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMPRSS15 Gene

Genomics for TMPRSS15 Gene

Genomic Location for TMPRSS15 Gene

18,269,116 bp from pter
18,485,879 bp from pter
216,764 bases
Minus strand

Genomic View for TMPRSS15 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMPRSS15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMPRSS15 Gene

No data available for Regulatory Elements for TMPRSS15 Gene

Proteins for TMPRSS15 Gene

  • Protein details for TMPRSS15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q2NKL7

    Protein attributes for TMPRSS15 Gene

    1019 amino acids
    Molecular mass:
    112935 Da
    Quaternary structure:
    • Heterodimer of a catalytic (light) chain and a multidomain (heavy) chain linked by a disulfide bond
    • Sequence=CAB90389.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TMPRSS15 Gene

neXtProt entry for TMPRSS15 Gene

Proteomics data for TMPRSS15 Gene at MOPED

Post-translational modifications for TMPRSS15 Gene

  • The chains are derived from a single precursor that is cleaved by a trypsin-like protease
  • Glycosylation at Asn116, Asn147, Asn179, Asn328, Asn335, Asn388, Asn440, Asn470, Asn503, Asn534, Asn630, Asn682, Asn706, Asn725, Asn848, Asn887, Asn909, and Asn949

Other Protein References for TMPRSS15 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for TMPRSS15 Gene

Gene Families for TMPRSS15 Gene

  • TMPRSS :Serine peptidases / Transmembrane


  • Contains 2 CUB domains.:
    • P98073
  • Contains 2 LDL-receptor class A domains.:
    • P98073
  • Contains 1 MAM domain.:
    • P98073
  • Contains 1 peptidase S1 domain.:
    • P98073
  • Contains 1 SEA domain.:
    • P98073
  • Contains 1 SRCR domain.:
    • P98073
  • Belongs to the peptidase S1 family.:
    • P98073
genes like me logo Genes that share domains with TMPRSS15: view

Function for TMPRSS15 Gene

Molecular function for TMPRSS15 Gene

UniProtKB/Swiss-Prot CatalyticActivity: Activation of trypsinogen by selective cleavage of 6-Lys- -Ile-7 bond
UniProtKB/Swiss-Prot Function: Responsible for initiating activation of pancreatic proteolytic proenzymes (trypsin, chymotrypsin and carboxypeptidase A). It catalyzes the conversion of trypsinogen to trypsin which in turn activates other proenzymes including chymotrypsinogen, procarboxypeptidases, and proelastases

Enzyme Numbers (IUBMB) for TMPRSS15 Gene

Gene Ontology (GO) - Molecular Function for TMPRSS15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004252 serine-type endopeptidase activity IEA --
GO:0005044 scavenger receptor activity IEA --
GO:0005515 protein binding IPI 24407287
genes like me logo Genes that share ontologies with TMPRSS15: view

Phenotypes for TMPRSS15 Gene

MGI mutant phenotypes for TMPRSS15:
inferred from 1 alleles
GenomeRNAi human phenotypes for TMPRSS15:
genes like me logo Genes that share phenotypes with TMPRSS15: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TMPRSS15 Gene

Localization for TMPRSS15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMPRSS15 Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

Jensen Localization Image for TMPRSS15 Gene COMPARTMENTS Subcellular localization image for TMPRSS15 gene
Compartment Confidence
plasma membrane 3
extracellular 2
golgi apparatus 2
cytosol 1
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for TMPRSS15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005903 brush border TAS 8052624
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMPRSS15: view

Pathways for TMPRSS15 Gene

SuperPathways for TMPRSS15 Gene

No Data Available

Interacting Proteins for TMPRSS15 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
Selected Interacting proteins: ENSP00000284885 P98073-ENTK_HUMAN for TMPRSS15 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for TMPRSS15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006898 receptor-mediated endocytosis IEA --
genes like me logo Genes that share ontologies with TMPRSS15: view

No data available for Pathways by source for TMPRSS15 Gene

Compounds for TMPRSS15 Gene

(19) Novoseek inferred chemical compound relationships for TMPRSS15 Gene

Compound -log(P) Hits PubMed IDs
trypsinogen 92.2 44
imac 66 3
chymotrypsinogen 63.9 2
hbd2 60.6 2
serine 56.7 16
genes like me logo Genes that share compounds with TMPRSS15: view

Transcripts for TMPRSS15 Gene

mRNA/cDNA for TMPRSS15 Gene

(7) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(13) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMPRSS15 Gene

Transmembrane protease, serine 15:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMPRSS15 Gene

No ASD Table

Relevant External Links for TMPRSS15 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMPRSS15 Gene

mRNA expression in normal human tissues for TMPRSS15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMPRSS15 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (47.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TMPRSS15 Gene

SOURCE GeneReport for Unigene cluster for TMPRSS15 Gene Hs.149473

mRNA Expression by UniProt/SwissProt for TMPRSS15 Gene

Tissue specificity: Intestinal brush border
genes like me logo Genes that share expressions with TMPRSS15: view

Orthologs for TMPRSS15 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMPRSS15 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMPRSS15 36
  • 99.18 (n)
  • 98.72 (a)
  • 99 (a)
(Bos Taurus)
Mammalia TMPRSS15 36
  • 86.33 (n)
  • 82.53 (a)
  • 81 (a)
(Canis familiaris)
Mammalia TMPRSS15 36
  • 88.52 (n)
  • 84.99 (a)
  • 84 (a)
(Mus musculus)
Mammalia Tmprss15 36
  • 80.21 (n)
  • 75.17 (a)
Tmprss15 16
Tmprss15 37
  • 72 (a)
(Monodelphis domestica)
Mammalia -- 37
  • 30 (a)
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 37 (a)
(Rattus norvegicus)
Mammalia Tmprss15 36
  • 78.48 (n)
  • 74.05 (a)
(Gallus gallus)
Aves TMPRSS15 36
  • 65.71 (n)
  • 57 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tmprss15 36
  • 63.73 (n)
  • 57.59 (a)
(Danio rerio)
Actinopterygii tmprss15 36
  • 54.97 (n)
  • 48.41 (a)
Species with no ortholog for TMPRSS15:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMPRSS15 Gene

Gene Tree for TMPRSS15 (if available)
Gene Tree for TMPRSS15 (if available)

Paralogs for TMPRSS15 Gene

genes like me logo Genes that share paralogs with TMPRSS15: view

Variants for TMPRSS15 Gene

Sequence variations from dbSNP and Humsavar for TMPRSS15 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type MAF
rs927 -- 18,269,705(-) ATTTT(A/T)AAAAT utr-variant-3-prime
rs1005 -- 18,269,706(-) CATTT(A/T)TAAAA utr-variant-3-prime
rs719521 -- 18,397,714(-) GTAGC(A/G)AATAA intron-variant
rs722682 -- 18,319,833(+) CCTCT(C/T)AGTAT intron-variant
rs724128 -- 18,322,944(-) ATCAT(A/C)GAATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMPRSS15 Gene

Variant ID Type Subtype PubMed ID
esv2751925 CNV Loss 17911159
nsv459105 CNV Loss 19166990
nsv819544 CNV Gain 19587683
nsv187307 CNV Insertion 16902084
nsv518906 CNV Loss 19592680
esv1003839 CNV Deletion 20482838
esv1470738 CNV Deletion 17803354
nsv522137 CNV Loss 19592680
nsv913433 CNV Loss 21882294
nsv913434 CNV Loss 21882294
nsv3470 CNV Insertion 18451855
nsv522760 CNV Loss 19592680
nsv459106 CNV Loss 19166990
esv2723212 CNV Deletion 23290073
esv2657867 CNV Deletion 23128226

Relevant External Links for TMPRSS15 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

Disorders for TMPRSS15 Gene

(1) OMIM Diseases for TMPRSS15 Gene (606635)


  • Enterokinase deficiency (ENTKD) [MIM:226200]: Life-threatening intestinal malabsorption disorder characterized by diarrhea and failure to thrive. {ECO:0000269 PubMed:11719902}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(2) University of Copenhagen DISEASES for TMPRSS15 Gene

(13) Novoseek inferred disease relationships for TMPRSS15 Gene

Disease -log(P) Hits PubMed IDs
enteropeptidase deficiency 94.6 9
pancreatitis 49.1 4
steatorrhea 38.4 1
chronic pancreatitis 36.4 3
acute pancreatitis 35.5 1

Relevant External Links for TMPRSS15

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with TMPRSS15: view

Publications for TMPRSS15 Gene

  1. Enterokinase, the initiator of intestinal digestion, is a mosaic protease composed of a distinctive assortment of domains. (PMID: 8052624) Kitamoto Y. … Sadler J.E. (Proc. Natl. Acad. Sci. U.S.A. 1994) 2 3 4 23
  2. Mutations in the proenteropeptidase gene are the molecular cause of congenital enteropeptidase deficiency. (PMID: 11719902) Holzinger A. … Roscher A.A. (Am. J. Hum. Genet. 2002) 3 4 23
  3. cDNA sequence and chromosomal localization of human enterokinase, the proteolytic activator of trypsinogen. (PMID: 7718557) Kitamoto Y. … Sadler J.E. (Biochemistry 1995) 3 4 23
  4. Keratinocytes synthesize enteropeptidase and multiple forms of trypsinogen during terminal differentiation. (PMID: 19924134) Nakanishi J. … Hibino T. (J. Invest. Dermatol. 2010) 3 23
  5. Crystal structure of a supercharged variant of the human enteropeptidase light chain. (PMID: 22488687) Simeonov P. … Zuchner T. (Proteins 2012) 3 4

Products for TMPRSS15 Gene

Sources for TMPRSS15 Gene

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