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Aliases for TMPRSS13 Gene

Aliases for TMPRSS13 Gene

  • Transmembrane Protease, Serine 13 2 3 5
  • Membrane-Type Mosaic Serine Protease 3 4
  • Transmembrane Protease, Serine 11 2 3
  • TMPRSS11 3 4
  • MSP 3 4
  • Mosaic Serine Protease 4
  • EC 3.4.21.109 63
  • EC 3.4.21.- 4
  • EC 3.4.21 63
  • MSPS 3
  • MSPL 3

External Ids for TMPRSS13 Gene

Previous HGNC Symbols for TMPRSS13 Gene

  • TMPRSS11

Previous GeneCards Identifiers for TMPRSS13 Gene

  • GC11M117277
  • GC11M117771
  • GC11M113705

Summaries for TMPRSS13 Gene

Entrez Gene Summary for TMPRSS13 Gene

  • This gene encodes a member of the type II transmembrane serine protease family. Transmembrane serine proteases are regulated by protease inhibitors and known to function in development, homeostasis, infection, and tumorigenesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for TMPRSS13 Gene

TMPRSS13 (Transmembrane Protease, Serine 13) is a Protein Coding gene. Diseases associated with TMPRSS13 include Avian Influenza. Among its related pathways are Influenza A. GO annotations related to this gene include serine-type endopeptidase activity and serine-type exopeptidase activity. An important paralog of this gene is TMPRSS11A.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMPRSS13 Gene

Genomics for TMPRSS13 Gene

Regulatory Elements for TMPRSS13 Gene

Enhancers for TMPRSS13 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TMPRSS13 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMPRSS13 Gene

Chromosome:
11
Start:
117,900,641 bp from pter
End:
117,929,459 bp from pter
Size:
28,819 bases
Orientation:
Minus strand

Genomic View for TMPRSS13 Gene

Genes around TMPRSS13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMPRSS13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMPRSS13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMPRSS13 Gene

Proteins for TMPRSS13 Gene

  • Protein details for TMPRSS13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BYE2-TMPSD_HUMAN
    Recommended name:
    Transmembrane protease serine 13
    Protein Accession:
    Q9BYE2
    Secondary Accessions:
    • B4DTM9
    • E9PIJ5
    • F8WAJ3
    • Q86YM4
    • Q96JY8
    • Q9BYE1

    Protein attributes for TMPRSS13 Gene

    Size:
    586 amino acids
    Molecular mass:
    63153 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMPRSS13 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMPRSS13 Gene

Proteomics data for TMPRSS13 Gene at MOPED

Selected DME Specific Peptides for TMPRSS13 Gene

Post-translational modifications for TMPRSS13 Gene

  • Glycosylation at Asn 255, Asn 292, Asn 405, and Asn 445
  • Modification sites at PhosphoSitePlus

Domains & Families for TMPRSS13 Gene

Gene Families for TMPRSS13 Gene

Suggested Antigen Peptide Sequences for TMPRSS13 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BYE2

UniProtKB/Swiss-Prot:

TMPSD_HUMAN :
  • Contains 1 LDL-receptor class A domain.
  • Belongs to the peptidase S1 family.
Domain:
  • Contains 1 LDL-receptor class A domain.
  • Contains 1 peptidase S1 domain.
  • Contains 1 SRCR domain.
Family:
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with TMPRSS13: view

Function for TMPRSS13 Gene

Enzyme Numbers (IUBMB) for TMPRSS13 Gene

genes like me logo Genes that share phenotypes with TMPRSS13: view

Animal Models for TMPRSS13 Gene

MGI Knock Outs for TMPRSS13:

Animal Model Products

CRISPR Products

miRNA for TMPRSS13 Gene

miRTarBase miRNAs that target TMPRSS13

No data available for Molecular function , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TMPRSS13 Gene

Localization for TMPRSS13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMPRSS13 Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMPRSS13 Gene COMPARTMENTS Subcellular localization image for TMPRSS13 gene
Compartment Confidence
extracellular 5
plasma membrane 3
cytosol 2
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TMPRSS13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA,NAS 11267681
GO:0072562 blood microparticle IDA 22516433
genes like me logo Genes that share ontologies with TMPRSS13: view

Pathways & Interactions for TMPRSS13 Gene

SuperPathways for TMPRSS13 Gene

Superpath Contained pathways
1 Influenza A
genes like me logo Genes that share pathways with TMPRSS13: view

Pathways by source for TMPRSS13 Gene

1 KEGG pathway for TMPRSS13 Gene

Interacting Proteins for TMPRSS13 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000434279%0d%0a9606.ENSP00000291582%0d%0a9606.ENSP00000350249%0d%0a
Selected Interacting proteins: ENSP00000434279 Q9BYE2-TMPSD_HUMAN for TMPRSS13 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for TMPRSS13 Gene

None

No data available for SIGNOR curated interactions for TMPRSS13 Gene

Drugs & Compounds for TMPRSS13 Gene

(2) Drugs for TMPRSS13 Gene - From: ApexBio and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
PMSF Pharma Serine proteinases inhibitor, irreversible 0

(1) Additional Compounds for TMPRSS13 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for TMPRSS13 Gene

Compound Action Cas Number
PMSF Serine proteinases inhibitor, irreversible 329-98-6
genes like me logo Genes that share compounds with TMPRSS13: view

Transcripts for TMPRSS13 Gene

Unigene Clusters for TMPRSS13 Gene

Transmembrane protease, serine 13:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMPRSS13 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16
SP1: - - - - -
SP2: -
SP3: -
SP4: - - - -
SP5:
SP6: - - - - -

Relevant External Links for TMPRSS13 Gene

GeneLoc Exon Structure for
TMPRSS13
ECgene alternative splicing isoforms for
TMPRSS13

Expression for TMPRSS13 Gene

mRNA expression in normal human tissues for TMPRSS13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMPRSS13 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x15.5), Skin - Not Sun Exposed (Suprapubic) (x11.6), and Esophagus - Mucosa (x5.9).

Protein differential expression in normal tissues from HIPED for TMPRSS13 Gene

This gene is overexpressed in Cervix (64.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TMPRSS13 Gene



SOURCE GeneReport for Unigene cluster for TMPRSS13 Gene Hs.266308

mRNA Expression by UniProt/SwissProt for TMPRSS13 Gene

Q9BYE2-TMPSD_HUMAN
Tissue specificity: Isoform 1 and isoform 3 are predominantly expressed in lung, placenta, pancreas, and prostate. Isoform 3 is weakly expressed in testis and peripheral blood lymphocytes.
genes like me logo Genes that share expression patterns with TMPRSS13: view

Protein tissue co-expression partners for TMPRSS13 Gene

Primer Products

Orthologs for TMPRSS13 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMPRSS13 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TMPRSS13 35
  • 83.47 (n)
  • 80.8 (a)
TMPRSS13 36
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMPRSS13 35
  • 87.07 (n)
  • 87.6 (a)
TMPRSS13 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmprss13 35
  • 85.4 (n)
  • 85.95 (a)
Tmprss13 16
Tmprss13 36
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TMPRSS13 35
  • 97.93 (n)
  • 96.71 (a)
TMPRSS13 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmprss13 35
  • 84.67 (n)
  • 84.86 (a)
oppossum
(Monodelphis domestica)
Mammalia TMPRSS13 36
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMPRSS13 36
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC100859131 35
  • 68.84 (n)
  • 62.56 (a)
TMPRSS13 36
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMPRSS13 36
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmprss13 35
  • 52.59 (n)
  • 44.94 (a)
zebrafish
(Danio rerio)
Actinopterygii tmprss13b 35
  • 50.63 (n)
  • 45.97 (a)
tmprss13a 36
  • 34 (a)
OneToMany
tmprss13b 36
  • 38 (a)
OneToMany
Species with no ortholog for TMPRSS13:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMPRSS13 Gene

ENSEMBL:
Gene Tree for TMPRSS13 (if available)
TreeFam:
Gene Tree for TMPRSS13 (if available)

Paralogs for TMPRSS13 Gene

genes like me logo Genes that share paralogs with TMPRSS13: view

Variants for TMPRSS13 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for TMPRSS13 Gene

TMPSD_HUMAN-Q9BYE2
The repeat A-S-P-A-[GLQR] is polymorphic and the number of copies varies between 12 to 14.

Sequence variations from dbSNP and Humsavar for TMPRSS13 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs543290 -- 117,900,283(+) CCAAA(A/C)CTGAC downstream-variant-500B
rs543480 -- 117,900,354(+) CCATG(C/T)GTGGT downstream-variant-500B
rs565745 -- 117,931,192(+) GGGCA(C/T)CCTCA upstream-variant-2KB
rs568060 -- 117,900,682(+) GCTGG(C/G)GGCTG utr-variant-3-prime
rs572675 -- 117,901,173(-) CCCAG(G/T)AGCTG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TMPRSS13 Gene

Variant ID Type Subtype PubMed ID
esv2745121 CNV Deletion 23290073

Variation tolerance for TMPRSS13 Gene

Residual Variation Intolerance Score: 90% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.15; 51.61% of all genes are more intolerant (likely to be disease-causing)

No data available for Relevant External Links for TMPRSS13 Gene

Disorders for TMPRSS13 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TMPRSS13 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
avian influenza
  • avian flu
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TMPRSS13

Genetic Association Database (GAD)
TMPRSS13
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMPRSS13
genes like me logo Genes that share disorders with TMPRSS13: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TMPRSS13 Gene

Publications for TMPRSS13 Gene

  1. Cloning and expression of novel mosaic serine proteases with and without a transmembrane domain from human lung. (PMID: 11267681) Kim D.R. … Kido H. (Biochim. Biophys. Acta 2001) 2 3 4 67
  2. Novel type II transmembrane serine proteases, MSPL and TMPRSS13, Proteolytically activate membrane fusion activity of the hemagglutinin of highly pathogenic avian influenza viruses and induce their multicycle replication. (PMID: 20219906) Okumura Y. … Kido H. (J. Virol. 2010) 3 23
  3. MSPL/TMPRSS13. (PMID: 17981585) Kido H. … Okumura Y. (Front. Biosci. 2008) 3 23
  4. DESC1 and MSPL activate influenza A viruses and emerging coronaviruses for host cell entry. (PMID: 25122802) Zmora P. … Bertram S. (J. Virol. 2014) 3
  5. LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells. (PMID: 23443559) Fogeron M.L. … Lange B.M. (Nat Commun 2013) 3

Products for TMPRSS13 Gene

Sources for TMPRSS13 Gene

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