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Aliases for TMPRSS13 Gene

Aliases for TMPRSS13 Gene

  • Transmembrane Protease, Serine 13 2 3 5
  • Membrane-Type Mosaic Serine Protease 3 4
  • Transmembrane Protease, Serine 11 2 3
  • TMPRSS11 3 4
  • MSP 3 4
  • Transmembrane Protease Serine 13 3
  • Mosaic Serine Protease 4
  • EC 61
  • EC 3.4.21.- 4
  • EC 3.4.21 61
  • MSPS 3
  • MSPL 3

External Ids for TMPRSS13 Gene

Previous HGNC Symbols for TMPRSS13 Gene

  • TMPRSS11

Previous GeneCards Identifiers for TMPRSS13 Gene

  • GC11M117277
  • GC11M117771
  • GC11M113705

Summaries for TMPRSS13 Gene

Entrez Gene Summary for TMPRSS13 Gene

  • This gene encodes a member of the type II transmembrane serine protease family. Transmembrane serine proteases are regulated by protease inhibitors and known to function in development, homeostasis, infection, and tumorigenesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for TMPRSS13 Gene

TMPRSS13 (Transmembrane Protease, Serine 13) is a Protein Coding gene. Diseases associated with TMPRSS13 include Avian Influenza. Among its related pathways are Influenza A. GO annotations related to this gene include serine-type endopeptidase activity and serine-type exopeptidase activity. An important paralog of this gene is TMPRSS2.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMPRSS13 Gene

Genomics for TMPRSS13 Gene

Regulatory Elements for TMPRSS13 Gene

Enhancers for TMPRSS13 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F117928 1.1 Ensembl ENCODE 26.2 -1.1 -1142 4.4 HDGF BCOR CTCF PKNOX1 ZMYM3 SIN3A CEBPG EBF1 RAD21 YY1 TMPRSS13 IFT46 TAGLN GC11M117924
GH11F117948 1.5 FANTOM5 Ensembl ENCODE 16.6 -22.1 -22091 5.9 PKNOX1 TBL1XR1 ARID4B RAD21 GLIS2 GATA2 SCRT2 ZNF143 ZNF263 ZNF654 IL10RA TMPRSS13 CD3E CD3G DSCAML1 ENSG00000254844 FXYD6 FXYD6-FXYD2 ENSG00000254528 FXYD2
GH11F117997 1.8 FANTOM5 Ensembl ENCODE 11 -77.6 -77599 19.5 HDGF PKNOX1 CREB3L1 WRNIP1 YBX1 ZNF143 ZNF207 FOS ZNF263 SP3 IL10RA PCSK7 ENSG00000254528 LOC101929133 CCDC84 IFT46 LOC653303 FXYD2 TMPRSS13 FXYD6
GH11F117814 1.7 FANTOM5 Ensembl ENCODE 10.9 +112.1 112076 6.8 HDGF PKNOX1 ARNT WRNIP1 ZFP64 ARID4B YBX1 ZNF2 GLIS2 ZNF143 IL10RA DSCAML1 FXYD2 LOC653303 FXYD6-FXYD2 FXYD6 RNF214 TMPRSS13 CEP164 TMEM25
GH11F117906 1.3 Ensembl ENCODE 12.8 +20.6 20574 4.1 HDGF PKNOX1 ATF1 ZNF133 GTF3C2 GATA2 FOS ZNF263 SP3 GTF2B ARCN1 UBE4A TMPRSS13 FXYD6 FXYD6-FXYD2 DSCAML1 ENSG00000254844 RNF214 ENSG00000254528 FXYD2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMPRSS13 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMPRSS13 Gene

117,900,641 bp from pter
117,929,459 bp from pter
28,819 bases
Minus strand

Genomic View for TMPRSS13 Gene

Genes around TMPRSS13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMPRSS13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMPRSS13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMPRSS13 Gene

Proteins for TMPRSS13 Gene

  • Protein details for TMPRSS13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protease serine 13
    Protein Accession:
    Secondary Accessions:
    • B4DTM9
    • E9PIJ5
    • F8WAJ3
    • Q86YM4
    • Q96JY8
    • Q9BYE1

    Protein attributes for TMPRSS13 Gene

    586 amino acids
    Molecular mass:
    63153 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMPRSS13 Gene


neXtProt entry for TMPRSS13 Gene

Selected DME Specific Peptides for TMPRSS13 Gene


Post-translational modifications for TMPRSS13 Gene

  • Glycosylation at Asn 255, Asn 292, Asn 405, and Asn 445
  • Modification sites at PhosphoSitePlus

Domains & Families for TMPRSS13 Gene

Gene Families for TMPRSS13 Gene

Suggested Antigen Peptide Sequences for TMPRSS13 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 LDL-receptor class A domain.
  • Belongs to the peptidase S1 family.
  • Contains 1 LDL-receptor class A domain.
  • Contains 1 peptidase S1 domain.
  • Contains 1 SRCR domain.
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with TMPRSS13: view

Function for TMPRSS13 Gene

Enzyme Numbers (IUBMB) for TMPRSS13 Gene

Gene Ontology (GO) - Molecular Function for TMPRSS13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004252 serine-type endopeptidase activity NAS 11267681
GO:0005044 scavenger receptor activity IEA --
GO:0008233 peptidase activity IEA --
GO:0008236 serine-type peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with TMPRSS13: view
genes like me logo Genes that share phenotypes with TMPRSS13: view

Animal Models for TMPRSS13 Gene

MGI Knock Outs for TMPRSS13:

Animal Model Products

miRNA for TMPRSS13 Gene

miRTarBase miRNAs that target TMPRSS13

Flow Cytometry Products

No data available for Molecular function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TMPRSS13 Gene

Localization for TMPRSS13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMPRSS13 Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMPRSS13 gene
Compartment Confidence
extracellular 5
plasma membrane 3
cytosol 2
peroxisome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for TMPRSS13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane NAS 11267681
GO:0072562 blood microparticle IDA 22516433
genes like me logo Genes that share ontologies with TMPRSS13: view

Pathways & Interactions for TMPRSS13 Gene

SuperPathways for TMPRSS13 Gene

SuperPathway Contained pathways
1 Influenza A
genes like me logo Genes that share pathways with TMPRSS13: view

Pathways by source for TMPRSS13 Gene

1 KEGG pathway for TMPRSS13 Gene

Interacting Proteins for TMPRSS13 Gene

Gene Ontology (GO) - Biological Process for TMPRSS13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006898 receptor-mediated endocytosis IEA --
genes like me logo Genes that share ontologies with TMPRSS13: view

No data available for SIGNOR curated interactions for TMPRSS13 Gene

Drugs & Compounds for TMPRSS13 Gene

(2) Drugs for TMPRSS13 Gene - From: ApexBio and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
PMSF Pharma Serine proteinases inhibitor, irreversible 0

(1) Additional Compounds for TMPRSS13 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for TMPRSS13 Gene

Compound Action Cas Number
PMSF Serine proteinases inhibitor, irreversible 329-98-6
genes like me logo Genes that share compounds with TMPRSS13: view

Transcripts for TMPRSS13 Gene

Unigene Clusters for TMPRSS13 Gene

Transmembrane protease, serine 13:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMPRSS13 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16
SP1: - - - - -
SP2: -
SP3: -
SP4: - - - -
SP6: - - - - -

Relevant External Links for TMPRSS13 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMPRSS13 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TMPRSS13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMPRSS13 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x15.5), Skin - Not Sun Exposed (Suprapubic) (x11.6), and Esophagus - Mucosa (x5.9).

Protein differential expression in normal tissues from HIPED for TMPRSS13 Gene

This gene is overexpressed in Cervix (64.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TMPRSS13 Gene

Protein tissue co-expression partners for TMPRSS13 Gene

NURSA nuclear receptor signaling pathways regulating expression of TMPRSS13 Gene:


SOURCE GeneReport for Unigene cluster for TMPRSS13 Gene:


mRNA Expression by UniProt/SwissProt for TMPRSS13 Gene:

Tissue specificity: Isoform 1 and isoform 3 are predominantly expressed in lung, placenta, pancreas, and prostate. Isoform 3 is weakly expressed in testis and peripheral blood lymphocytes.
genes like me logo Genes that share expression patterns with TMPRSS13: view

Primer Products

Orthologs for TMPRSS13 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMPRSS13 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMPRSS13 34 35
  • 97.93 (n)
(Canis familiaris)
Mammalia TMPRSS13 34 35
  • 87.07 (n)
(Mus musculus)
Mammalia Tmprss13 34 16 35
  • 85.4 (n)
(Rattus norvegicus)
Mammalia Tmprss13 34
  • 84.67 (n)
(Bos Taurus)
Mammalia TMPRSS13 34 35
  • 83.47 (n)
(Monodelphis domestica)
Mammalia TMPRSS13 35
  • 67 (a)
(Ornithorhynchus anatinus)
Mammalia TMPRSS13 35
  • 67 (a)
(Gallus gallus)
Aves LOC100859131 34
  • 68.84 (n)
  • 61 (a)
(Anolis carolinensis)
Reptilia TMPRSS13 35
  • 57 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tmprss13 34
  • 52.59 (n)
(Danio rerio)
Actinopterygii tmprss13b 34 35
  • 50.63 (n)
tmprss13a 35
  • 34 (a)
Species where no ortholog for TMPRSS13 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMPRSS13 Gene

Gene Tree for TMPRSS13 (if available)
Gene Tree for TMPRSS13 (if available)

Paralogs for TMPRSS13 Gene

genes like me logo Genes that share paralogs with TMPRSS13: view

Variants for TMPRSS13 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for TMPRSS13 Gene

The repeat A-S-P-A-[GLQR] is polymorphic and the number of copies varies between 12 to 14.

Sequence variations from dbSNP and Humsavar for TMPRSS13 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs10160708 -- 117,911,366(+) GAGAA(C/T)GGGCC intron-variant
rs10458983 -- 117,915,783(+) CCACC(C/T)GTGGG intron-variant
rs10667002 -- 117,907,911(+) GAATG(-/GAAT)AATGA intron-variant, utr-variant-3-prime
rs10732858 -- 117,911,268(+) CTTCC(A/C)ACGTG intron-variant
rs10790220 -- 117,919,943(+) GCCCC(C/G)TGGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMPRSS13 Gene

Variant ID Type Subtype PubMed ID
esv2745121 CNV deletion 23290073

Variation tolerance for TMPRSS13 Gene

Residual Variation Intolerance Score: 90% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.15; 51.61% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMPRSS13 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

Disorders for TMPRSS13 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TMPRSS13 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
avian influenza
  • avian flu
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TMPRSS13

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TMPRSS13: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TMPRSS13 Gene

Publications for TMPRSS13 Gene

  1. Cloning and expression of novel mosaic serine proteases with and without a transmembrane domain from human lung. (PMID: 11267681) Kim D.R. … Kido H. (Biochim. Biophys. Acta 2001) 2 3 4 64
  2. Novel type II transmembrane serine proteases, MSPL and TMPRSS13, Proteolytically activate membrane fusion activity of the hemagglutinin of highly pathogenic avian influenza viruses and induce their multicycle replication. (PMID: 20219906) Okumura Y. … Kido H. (J. Virol. 2010) 3 22 64
  3. MSPL/TMPRSS13. (PMID: 17981585) Kido H. … Okumura Y. (Front. Biosci. 2008) 3 22 64
  4. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 3 4 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for TMPRSS13 Gene

Sources for TMPRSS13 Gene

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