TMPRSS12 Gene
protein-coding GIFtS: 41
GCID: GC12P051236
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transmembrane (C-terminal) protease, serine 12(Previous names: transmembrane protease, serine 12 )
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Aliases
for TMPRSS12 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Transmembrane (C-Terminal) Protease, Serine 121 2 | | EC 3.4.21.-3 | | Transmembrane Protease, Serine 121 2 | | EC 3.4.218 | | MGC573411 | | EC 3.4.21.48 | | Transmembrane Protease Serine 122 | | |
Export aliases for TMPRSS12 gene to outside databasesPrevious GC identifers: GC12P049523 GC12P048269 |
Summaries
for TMPRSS12 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for TMPRSS12 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_029419.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TMPRSS12 gene promoter:
HFH-3 FOXI1 Pax-3 PPAR-gamma1 Brachyury PPAR-gamma2 HNF-3beta
Other transcription factors
Search SABiosciences Chromatin IP Primers for TMPRSS12
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMPRSS12 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q13.12 Ensembl cytogenetic band: 12q13.12 HGNC cytogenetic band: 12q13.12TMPRSS12 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12P051236: view genomic region
(about GC identifiers)
Start:
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51,236,701 bp from pter |
End:
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51,281,667 bp from pter |
Size:
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44,967 bases |
Orientation:
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plus strand |
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Proteins
for TMPRSS12 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TMPSC_HUMAN, Q86WS5 (See
protein sequence)Recommended Name: Transmembrane protease serine 12 precursor Size: 348 amino acids; 38605 Da
Subcellular location: Membrane; Single-pass membrane protein (Potential)
Secondary accessions: B9ZVX2Explore the universe of human proteins at neXtProt for TMPRSS12: NX_Q86WS5
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q86WS5
4 DME Specific Peptides for TMPRSS12 (Q86WS5)
TMPRSS12 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_872365.1
ENSEMBL proteins: ENSP00000447259 ENSP00000381476
Human Recombinant Protein Products for TMPRSS12:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
TMPRSS12 for ontologies About GeneDecksing
TMPRSS12 Antibody Products:
Assay Products for TMPRSS12: |
Protein
Domains /
Families
for TMPRSS12 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TMPRSS12 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q86WS5ProtoNet protein and cluster: Q86WS5 2 Blocks protein families: IPB001254 Serine protease IPB001314 Chymotrypsin serine protease family (S1) signature
UniProtKB/Swiss-Prot: TMPSC_HUMAN, Q86WS5Similarity: Belongs to the peptidase S1 familySimilarity: Contains 1 peptidase S1 domain |
Function
for TMPRSS12 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Enzyme Numbers (IUBMB): EC 3.4.21.42 EC 3.4.212 EC 3.4.21.-1
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004252 | serine-type endopeptidase activity |
IEA | -- |
TMPRSS12 for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMPRSS12 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMPRSS12
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TMPRSS12 (NM_182559) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMPRSS12 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMPRSS12 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMPRSS12 |
|
Pathways & Interactions
for TMPRSS12 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMPRSS12
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0006508 | proteolysis |
IEA | -- |
TMPRSS12 for ontologies About GeneDecksing
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Drugs & Compounds
for TMPRSS12 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TMPRSS12
Search CenterWatch for drugs/clinical trials and news about TMPRSS12 / TMPSC
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Transcripts
for TMPRSS12 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TMPRSS12 gene: NM_182559.2 Unigene Cluster for TMPRSS12: Transmembrane (C-terminal) protease, serine 12 Hs.125571 [show with all ESTs]Unigene Representative Sequence: NM_1825592 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000551456(uc001rwx.4 uc001rwy.3) ENST00000398458
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMPRSS12 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMPRSS12
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TMPRSS12 (NM_182559) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMPRSS12 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMPRSS12 |
Additional cDNA sequence: BC048112.1 2 DOTS entries: DT.91965217 DT.101978411 16 AceView cDNA sequences: CR596226 BU568547 NM_182559 BC048112 CD557275 BG722203 BX118966 BC035123 BG722131 AA884376 BM553993 BI549447 AW664814 BF364117 BX379643 BF364116
GeneLoc Exon Structure
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Expression
for TMPRSS12 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TMPRSS12 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGAACATTTT
About this image
See TMPRSS12 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TMPRSS12
SOURCE GeneReport for Unigene cluster: Hs.125571
SABiosciences Custom PCR Arrays for TMPRSS12
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMPRSS12
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TMPRSS12 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMPRSS12 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMPRSS12 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMPRSS12 |
Orthologs
for TMPRSS12 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for TMPRSS12 gene from 5/14 species (see all 14) About this table
ENSEMBL Gene Tree for TMPRSS12 (if available)
TreeFam Gene Tree for TMPRSS12 (if available) |
Paralogs
for TMPRSS12 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TMPRSS12 gene
- ACR2 PRSS542
18/79 SIMAP similar genes for TMPRSS12 using alignment to 2 protein entries: TMPSC_HUMAN (see all proteins)
(see all similar genes):DKFZp779M0222 PRSS46 TMPRSS2 TMPRSS11D PRSS22 PRSS45
PRSS48 TMPRSS13 TMPRSS15 CELA2B PRSS42 ST14
TMPRSS3 F12 PRSS38 TMPRSS6 CELA1 GZMM
TMPRSS12 for paralogs About GeneDecksing
|
Genomic Variants
for TMPRSS12 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TMPRSS12 (51236701 - 51281667 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TMPRSS12: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMPRSS12 |
|
Disorders
/ Diseases
for TMPRSS12 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 TMPRSS12 for disorders About MalaCards
TMPRSS12 for disorders About GeneDecksing
Human Genome Epidemiology (HuGE) Navigator: TMPRSS12 (1 document)
Export disorders for TMPRSS12 gene to outside databases
|
Publications
for TMPRSS12 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TMPRSS12 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TMPRSS12) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- The finished DNA sequence of human chromosome 12. (PubMed id 16541075)2 Scherer S.E.... Gibbs R.A. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for TMPRSS12 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing TMPRSS12 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing TMPRSS12 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TMPRSS12 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TMPRSS12 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for TMPRSS12 gene:
Search GeneIP for patents involving TMPRSS12
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TMPRSS12 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
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 | |
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TMPRSS12 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMPRSS12 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMPRSS12 | | | OriGene Protein Over-expression Lysate for TMPRSS12 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TMPRSS12 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMPRSS12 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMPRSS12 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TMPRSS12 | | OriGene Custom Protein Services for TMPRSS12 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TMPRSS12 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMPRSS12 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMPRSS12 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMPRSS12 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMPRSS12 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMPRSS12 |
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 | | | TMPRSS12 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMPRSS12 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for TMPRSS12 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMPRSS12 |
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