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TMPRSS12 Gene

protein-coding   GIFtS: 47
GCID: GC12P051236

Transmembrane (C-Terminal) Protease, Serine 12

(Previous names: transmembrane protease, serine 12)
  Search for TMPRSS12
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Transmembrane (C-Terminal) Protease, Serine 121 2     EC 3.4.21.-3
Transmembrane Protease, Serine 121 2     EC 3.4.218
CT1512     EC 3.4.21.48
Transmembrane Protease Serine 122     

External Ids:    HGNC: 287791   Entrez Gene: 2834712   Ensembl: ENSG000001864527   UniProtKB: Q86WS53   

Export aliases for TMPRSS12 gene to outside databases

Previous GC identifers: GC12P049523 GC12P048269


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TMPRSS12 Gene:
TMPRSS12 (transmembrane (C-terminal) protease, serine 12) is a protein-coding gene. GO annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is PRSS56.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NC_018923.2  NT_029419.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the TMPRSS12 gene promoter:
         HFH-3   FOXI1   Pax-3   PPAR-gamma1   Brachyury   PPAR-gamma2   HNF-3beta   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMPRSS12 promoter sequence
   Search Chromatin IP Primers for TMPRSS12

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TMPRSS12


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.12   Ensembl cytogenetic band:  12q13.12   HGNC cytogenetic band: 12q13.12

TMPRSS12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMPRSS12 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P051236:  view genomic region     (about GC identifiers)

Start:
51,236,701 bp from pter      End:
51,281,667 bp from pter
Size:
44,967 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TMPSC_HUMAN, Q86WS5 (See protein sequence)
Recommended Name: Transmembrane protease serine 12 precursor  
Size: 348 amino acids; 38605 Da
Secondary accessions: B9ZVX2

Explore the universe of human proteins at neXtProt for TMPRSS12: NX_Q86WS5

Explore proteomics data for TMPRSS12 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn219, Asn249
  • 4 DME Specific Peptides for TMPRSS12 (Q86WS5)
     GDSGGPL  VLTAAHC  WVLTAAH  WVLTAAHCT 


    See TMPRSS12 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_872365.1  
    ENSEMBL proteins: 
     ENSP00000447259   ENSP00000381476  

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    Cloud-Clone Corp. Proteins for TMPRSS12

     
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    Cloud-Clone Corp. CLIAs for TMPRSS12
    Search eBioscience for ELISAs for TMPRSS12 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TMPRSS: Serine peptidases / Transmembrane

    4 InterPro protein domains:
     IPR001314 Peptidase_S1A
     IPR009003 Trypsin-like_Pept_dom
     IPR001254 Peptidase_S1
     IPR018114 Peptidase_S1_AS

    Graphical View of Domain Structure for InterPro Entry Q86WS5

    ProtoNet protein and cluster: Q86WS5

    2 Blocks protein domains:
    IPB001254 Serine protease
    IPB001314 Chymotrypsin serine protease family (S1) signature


    UniProtKB/Swiss-Prot: TMPSC_HUMAN, Q86WS5
    Similarity: Belongs to the peptidase S1 family
    Similarity: Contains 1 peptidase S1 domain


    Find genes that share domains with TMPRSS12           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Enzyme Numbers (IUBMB): EC 3.4.21.42 EC 3.4.212 EC 3.4.21.-1

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004252serine-type endopeptidase activity IEA--
         
    Find genes that share ontologies with TMPRSS12           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TMPRSS12
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TMPRSS12
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TMPRSS12

    miRNA
    Products:
        
    miRTarBase miRNAs that target TMPRSS12:
    hsa-mir-335-5p (MIRT016740)

    Block miRNA regulation of human, mouse, rat TMPRSS12 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate TMPRSS12:
    hsa-miR-302f
    SwitchGear 3'UTR luciferase reporter plasmidTMPRSS12 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat TMPRSS12

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    Sino Biological Human cDNA Clone for TMPRSS12
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMPRSS12

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TMPSC_HUMAN, Q86WS5: Membrane; Single-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum1
    extracellular1
    nucleus1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with TMPRSS12           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TMPRSS12
    Interactions:

        Search GeneGlobe Interaction Network for TMPRSS12

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis ----

    Find genes that share ontologies with TMPRSS12           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TMPRSS12 (TMPSC)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TMPRSS12 gene: 
    NM_182559.2  

    Unigene Cluster for TMPRSS12:

    Transmembrane (C-terminal) protease, serine 12
    Hs.125571  [show with all ESTs]
    Unigene Representative Sequence: NM_182559
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000551456(uc001rwx.4 uc001rwy.3) ENST00000398458
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TMPRSS12 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate TMPRSS12:
    hsa-miR-302f
    SwitchGear 3'UTR luciferase reporter plasmidTMPRSS12 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TMPRSS12
    Predesigned siRNA for gene silencing in human, mouse, rat TMPRSS12
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    OriGene ORF clones in mouse, rat for TMPRSS12
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TMPRSS12 (NM_182559)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMPRSS12
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMPRSS12
    Primer
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    OriGene qPCR primer pairs and template standards for TMPRSS12
    OriGene qSTAR qPCR primer pairs in human, mouse for TMPRSS12
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TMPRSS12
      QuantiTect SYBR Green Assays in human, mouse, rat TMPRSS12
      QuantiFast Probe-based Assays in human, mouse, rat TMPRSS12

    Additional mRNA sequence: BC048112.1 

    2 DOTS entries:

    DT.91965217  DT.101978411 

    16 AceView cDNA sequences:

    CR596226 BC035123 BX118966 BG722203 BG722131 BU568547 NM_182559 AA884376 
    CD557275 BC048112 BM553993 AW664814 BI549447 BF364117 BX379643 BF364116 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TMPRSS12 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGAACATTTT
    TMPRSS12 Expression
    About this image

    TMPRSS12 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TMPRSS12 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.125571

    UniProtKB/Swiss-Prot: TMPSC_HUMAN, Q86WS5
    Tissue specificity: In testis, expressed in spermatocytes and spermatids. Expressed in colorectal cancer (at
    protein level)

        Custom PCR Arrays for TMPRSS12
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMPRSS12

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TMPRSS12 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tmprss121 , 5 transmembrane (C-terminal) protease, serine 121, 5 72.44(n)1
    62.01(a)1
      15 (56.24 cM)5
    750021  NM_183109.31  NP_898932.21 
     1002808375 
    chicken
    (Gallus gallus)
    Aves TMPRSS121 transmembrane (C-terminal) protease, serine 12 53.78(n)
    47.87(a)
      426872  XM_424480.3  XP_424480.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    41(a)
    38(a)
    many → 1
    many → 1
    2(91098855-91105160)
    2(91002323-91009405)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia tmprss121 transmembrane (C-terminal) protease, serine 12 55.38(n)
    49.03(a)
      100127698  NM_001113037.1  NP_001106508.1 
    zebrafish
    (Danio rerio)
    Actinopterygii TMPRSS126
    transmembrane (C-terminal) protease, serine 12
    25(a)
    1 ↔ 1
    23(27592709-27597315) ENSDARG00000094330
    fruit fly
    (Drosophila melanogaster)
    Insecta CG343506
    CG82136
    (see all 30)
    --
    9(a)
    6(a)
    (see all 30)
    many ↔ many
    many ↔ many
    (see all 30)
    2R(4881047-4894092)
    2R(4856841-4873063)


    ENSEMBL Gene Tree for TMPRSS12 (if available)
    TreeFam Gene Tree for TMPRSS12 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TMPRSS12 gene
    PRSS562  ACR2  OVCH22  OVCH12  
    Selected SIMAP similar genes for TMPRSS12 using alignment to 2 protein entries:     TMPSC_HUMAN (see all proteins) (see all similar genes):
    DKFZp779M0222    KLK3    PRSS46    TMPRSS2    TMPRSS11D    PRSS22
    PRSS45    PRSS48    TMPRSS13    TMPRSS15    CELA2B    PRSS42
    TMPRSS3    F12    PRSS38    PRSS56    ST14    TMPRSS6

    Find genes that share paralogs with TMPRSS12           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TMPRSS12 (see all 859)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1462327521,2
    --51068348(+) TAGGGG/TGTCAG 1 -- us2k10--------
    rs1823141271,2
    --51068385(+) GTGATC/TGGGGA 1 -- us2k10--------
    rs1484509771,2
    --51068415(+) TCATGC/TGGTGT 1 -- us2k10--------
    rs747898861,2
    C,F--51068651(+) AGTCAC/TGAAAT 1 -- us2k11Minor allele frequency- T:0.04WA 118
    rs1878534311,2
    --51068675(+) AAGGAA/GAGGGA 1 -- us2k10--------
    rs1149393931,2
    C,F--51068718(+) GTTCAT/CTGGCG 1 -- us2k11Minor allele frequency- C:0.01WA 118
    rs777615041,2
    F--51068722(+) ATTGGC/TGGGCA 1 -- us2k11Minor allele frequency- T:0.04WA 118
    rs124262231,2
    C,F,H--51068868(+) CCACTG/CCCttt 1 -- us2k1 tfbs35Minor allele frequency- C:0.00NS EA NA 422
    rs8291181,2
    C,H--51068924(+) ggagtG/Actgtg 1 -- us2k113Minor allele frequency- A:0.04NA WA CSA EA 376
    rs733112711,2
    C,F--51068941(+) CACAGG/ACATGA 1 -- us2k13Minor allele frequency- A:0.28WA CSA 122

    HapMap Linkage Disequilibrium report for TMPRSS12 (51236701 - 51281667 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for TMPRSS12:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2669568CNV Deletion23128226
    esv1433992CNV Insertion17803354
    nsv899078CNV Loss21882294

    Human Gene Mutation Database (HGMD): TMPRSS12
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TMPRSS12
    DNA2.0 Custom Variant and Variant Library Synthesis for TMPRSS12

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with TMPRSS12           About GenesLikeMe

    Genetic Association Database (GAD): TMPRSS12
    Human Genome Epidemiology (HuGE) Navigator: TMPRSS12 (1 document)

    Export disorders for TMPRSS12 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TMPRSS12 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with TMPRSS12)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    2. Scanning of novel cancer/testis proteins by human testis proteomic analysis. (PubMed id 23436708)2 Liu M....Sha J. (Proteomics 2013)
    3. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)
    4. The finished DNA sequence of human chromosome 12. (PubMed id 16541075)2 Scherer S.E.... Gibbs R.A. (Nature 2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 283471 HGNC: 28779 AceView: MGC57341 Ensembl:ENSG00000186452 euGenes: HUgn283471
    ECgene: TMPRSS12 H-InvDB: TMPRSS12

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TMPRSS12 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TMPRSS12 gene:
    Search GeneIP for patents involving TMPRSS12

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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for TMPRSS12  
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     QuantiFast Probe-based Assays in human, mouse, rat TMPRSS12 QuantiTect SYBR Green Assays in human, mouse, rat TMPRSS12
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     Search Addgene for plasmids for TMPRSS12
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