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Aliases for TMPRSS12 Gene

Aliases for TMPRSS12 Gene

  • Transmembrane (C-Terminal) Protease, Serine 12 2 3
  • Transmembrane Protease, Serine 12 2 3
  • Transmembrane Protease Serine 12 3
  • EC 3.4.21.4 63
  • EC 3.4.21.- 4
  • EC 3.4.21 63
  • CT151 3

External Ids for TMPRSS12 Gene

Previous GeneCards Identifiers for TMPRSS12 Gene

  • GC12P049523
  • GC12P051236
  • GC12P048269

Summaries for TMPRSS12 Gene

GeneCards Summary for TMPRSS12 Gene

TMPRSS12 is a Protein Coding gene. GO annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is PRSS56.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMPRSS12 Gene

Genomics for TMPRSS12 Gene

Regulatory Elements for TMPRSS12 Gene

Genomic Location for TMPRSS12 Gene

Start:
50,842,918 bp from pter
End:
50,887,884 bp from pter
Size:
44,967 bases
Orientation:
Plus strand

Genomic View for TMPRSS12 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMPRSS12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMPRSS12 Gene

Proteins for TMPRSS12 Gene

  • Protein details for TMPRSS12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86WS5-TMPSC_HUMAN
    Recommended name:
    Transmembrane protease serine 12
    Protein Accession:
    Q86WS5
    Secondary Accessions:
    • B9ZVX2

    Protein attributes for TMPRSS12 Gene

    Size:
    348 amino acids
    Molecular mass:
    38605 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMPRSS12 Gene

Proteomics data for TMPRSS12 Gene at MOPED

Selected DME Specific Peptides for TMPRSS12 Gene

Post-translational modifications for TMPRSS12 Gene

  • Glycosylation at Asn219 and Asn249
  • Modification sites at PhosphoSitePlus

Other Protein References for TMPRSS12 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for TMPRSS12 Gene

Gene Families for TMPRSS12 Gene

HGNC:
  • TMPRSS :Serine peptidases / Transmembrane

Suggested Antigen Peptide Sequences for TMPRSS12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86WS5

UniProtKB/Swiss-Prot:

TMPSC_HUMAN :
  • Q86WS5
Domain:
  • Contains 1 peptidase S1 domain.
Family:
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with TMPRSS12: view

Function for TMPRSS12 Gene

Enzyme Numbers (IUBMB) for TMPRSS12 Gene

Gene Ontology (GO) - Molecular Function for TMPRSS12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004252 serine-type endopeptidase activity IEA --
genes like me logo Genes that share ontologies with TMPRSS12: view

Animal Model Products

CRISPR Products

miRNA for TMPRSS12 Gene

miRTarBase miRNAs that target TMPRSS12

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMPRSS12

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TMPRSS12 Gene

Localization for TMPRSS12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMPRSS12 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMPRSS12 Gene COMPARTMENTS Subcellular localization image for TMPRSS12 gene
Compartment Confidence
endoplasmic reticulum 1
extracellular 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for TMPRSS12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMPRSS12: view

Pathways for TMPRSS12 Gene

SuperPathways for TMPRSS12 Gene

No Data Available

Interacting Proteins for TMPRSS12 Gene

Gene Ontology (GO) - Biological Process for TMPRSS12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with TMPRSS12: view

No data available for Pathways by source for TMPRSS12 Gene

Transcripts for TMPRSS12 Gene

mRNA/cDNA for TMPRSS12 Gene

(16) Selected AceView cDNA sequences:
(1) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMPRSS12 Gene

Transmembrane (C-terminal) protease, serine 12:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMPRSS12

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMPRSS12 Gene

No ASD Table

Relevant External Links for TMPRSS12 Gene

GeneLoc Exon Structure for
TMPRSS12
ECgene alternative splicing isoforms for
TMPRSS12

Expression for TMPRSS12 Gene

mRNA expression in normal human tissues for TMPRSS12 Gene

mRNA differential expression in normal tissues according to GTEx for TMPRSS12 Gene

This gene is overexpressed in Testis (48.4).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for TMPRSS12 Gene

SOURCE GeneReport for Unigene cluster for TMPRSS12 Gene Hs.125571

mRNA Expression by UniProt/SwissProt for TMPRSS12 Gene

Q86WS5-TMPSC_HUMAN
Tissue specificity: In testis, expressed in spermatocytes and spermatids. Expressed in colorectal cancer (at protein level).
genes like me logo Genes that share expressions with TMPRSS12: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for TMPRSS12 Gene

Orthologs for TMPRSS12 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMPRSS12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMPRSS12 35
  • 99.04 (n)
  • 98.85 (a)
TMPRSS12 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMPRSS12 35
  • 81.65 (n)
  • 69.74 (a)
dog
(Canis familiaris)
Mammalia TMPRSS12 35
  • 79.77 (n)
  • 69.08 (a)
TMPRSS12 36
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmprss12 35
  • 72.44 (n)
  • 62.01 (a)
Tmprss12 16
Tmprss12 36
  • 60 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 48 (a)
OneToMany
-- 36
  • 52 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia TMPRSS12 36
  • 48 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmprss12 35
  • 71.15 (n)
  • 61.56 (a)
chicken
(Gallus gallus)
Aves TMPRSS12 35
  • 53.78 (n)
  • 47.87 (a)
TMPRSS12 36
  • 45 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 38 (a)
OneToMany
-- 36
  • 41 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia tmprss12 35
  • 55.38 (n)
  • 49.03 (a)
zebrafish
(Danio rerio)
Actinopterygii TMPRSS12 36
  • 25 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG11668 36
  • 19 (a)
ManyToMany
CG11670 36
  • 17 (a)
ManyToMany
CG11836 36
  • 30 (a)
ManyToMany
CG11841 36
  • 24 (a)
ManyToMany
CG11842 36
  • 23 (a)
ManyToMany
CG11843 36
  • 23 (a)
ManyToMany
CG1299 36
  • 16 (a)
ManyToMany
CG14642 36
  • 21 (a)
ManyToMany
CG14892 36
  • 19 (a)
ManyToMany
CG18735 36
  • 21 (a)
ManyToMany
CG31728 36
  • 13 (a)
ManyToMany
CG32260 36
  • 16 (a)
ManyToMany
CG3355 36
  • 25 (a)
ManyToMany
CG34350 36
  • 9 (a)
ManyToMany
CG3700 36
  • 21 (a)
ManyToMany
CG4386 36
  • 20 (a)
ManyToMany
CG4613 36
  • 21 (a)
ManyToMany
CG4914 36
  • 23 (a)
ManyToMany
CG4927 36
  • 21 (a)
ManyToMany
CG6361 36
  • 12 (a)
ManyToMany
CG6865 36
  • 29 (a)
ManyToMany
CG7432 36
  • 12 (a)
ManyToMany
CG8172 36
  • 15 (a)
ManyToMany
CG8213 36
  • 6 (a)
ManyToMany
CG9294 36
  • 20 (a)
ManyToMany
CG9372 36
  • 21 (a)
ManyToMany
psh 36
  • 20 (a)
ManyToMany
Sb 36
  • 11 (a)
ManyToMany
snk 36
  • 20 (a)
ManyToMany
spirit 36
  • 19 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10974 36
  • 17 (a)
ManyToMany
Species with no ortholog for TMPRSS12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMPRSS12 Gene

ENSEMBL:
Gene Tree for TMPRSS12 (if available)
TreeFam:
Gene Tree for TMPRSS12 (if available)

Paralogs for TMPRSS12 Gene

Paralogs for TMPRSS12 Gene

genes like me logo Genes that share paralogs with TMPRSS12: view

Variants for TMPRSS12 Gene

Sequence variations from dbSNP and Humsavar for TMPRSS12 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs829118 -- 50,841,534(+) ggagt(A/G)ctgtg upstream-variant-2KB
rs829119 -- 50,841,935(+) TATCA(C/T)GTTGG upstream-variant-2KB
rs829120 -- 50,842,718(+) TTCCG(C/G)CTAAC upstream-variant-2KB
rs829126 -- 50,850,326(+) gtaat(A/C)ccagc intron-variant
rs829127 -- 50,850,919(+) ttaga(C/G)cttat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMPRSS12 Gene

Variant ID Type Subtype PubMed ID
nsv899078 CNV Loss 21882294
esv1433992 CNV Insertion 17803354
esv2669568 CNV Deletion 23128226

Relevant External Links for TMPRSS12 Gene

HapMap Linkage Disequilibrium report
TMPRSS12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMPRSS12 Gene

Disorders for TMPRSS12 Gene

Relevant External Links for TMPRSS12

Genetic Association Database (GAD)
TMPRSS12
Human Genome Epidemiology (HuGE) Navigator
TMPRSS12
genes like me logo Genes that share disorders with TMPRSS12: view

No data available for UniProtKB/Swiss-Prot for TMPRSS12 Gene

Publications for TMPRSS12 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  2. Systematic screening reveals a role for BRCA1 in the response to transcription-associated DNA damage. (PMID: 25184681) Hill S.J. … Livingston D.M. (Genes Dev. 2014) 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  4. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer S.E. … Gibbs R.A. (Nature 2006) 4
  5. Scanning of novel cancer/testis proteins by human testis proteomic analysis. (PMID: 23436708) Liu M. … Sha J. (Proteomics 2013) 4

Products for TMPRSS12 Gene

Sources for TMPRSS12 Gene

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