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Aliases for TMPRSS11F Gene

Aliases for TMPRSS11F Gene

  • Transmembrane Protease, Serine 11F 2 3 5
  • Airway Trypsin-Like Protease 4 4
  • EC 63
  • EC 3.4.21.- 4
  • EC 3.4.21 63
  • HATL4 4

External Ids for TMPRSS11F Gene

Previous GeneCards Identifiers for TMPRSS11F Gene

  • GC04M068748
  • GC04M068601
  • GC04M068918
  • GC04M064834

Summaries for TMPRSS11F Gene

GeneCards Summary for TMPRSS11F Gene

TMPRSS11F (Transmembrane Protease, Serine 11F) is a Protein Coding gene. GO annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is TMPRSS11A.

UniProtKB/Swiss-Prot for TMPRSS11F Gene

  • Probable serine protease.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMPRSS11F Gene

Genomics for TMPRSS11F Gene

Regulatory Elements for TMPRSS11F Gene

Enhancers for TMPRSS11F Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TMPRSS11F on UCSC Golden Path with GeneCards custom track

Genomic Location for TMPRSS11F Gene

68,053,198 bp from pter
68,129,880 bp from pter
76,683 bases
Minus strand

Genomic View for TMPRSS11F Gene

Genes around TMPRSS11F on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMPRSS11F Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMPRSS11F Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMPRSS11F Gene

Proteins for TMPRSS11F Gene

  • Protein details for TMPRSS11F Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protease serine 11F
    Protein Accession:
    Secondary Accessions:
    • A8MXX2

    Protein attributes for TMPRSS11F Gene

    438 amino acids
    Molecular mass:
    49410 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMPRSS11F Gene

Proteomics data for TMPRSS11F Gene at MOPED

Selected DME Specific Peptides for TMPRSS11F Gene

Post-translational modifications for TMPRSS11F Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMPRSS11F Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for TMPRSS11F Gene

Gene Families for TMPRSS11F Gene

Suggested Antigen Peptide Sequences for TMPRSS11F Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 peptidase S1 domain.
  • Belongs to the peptidase S1 family.
  • Contains 1 peptidase S1 domain.
  • Contains 1 SEA domain.
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with TMPRSS11F: view

Function for TMPRSS11F Gene

Molecular function for TMPRSS11F Gene

UniProtKB/Swiss-Prot Function:
Probable serine protease.

Enzyme Numbers (IUBMB) for TMPRSS11F Gene

genes like me logo Genes that share phenotypes with TMPRSS11F: view

Animal Model Products

CRISPR Products

miRNA for TMPRSS11F Gene

miRTarBase miRNAs that target TMPRSS11F

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMPRSS11F Gene

Localization for TMPRSS11F Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMPRSS11F Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

Jensen Localization Image for TMPRSS11F Gene COMPARTMENTS Subcellular localization image for TMPRSS11F gene
Compartment Confidence
plasma membrane 4
extracellular 2
cytosol 1
endoplasmic reticulum 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for TMPRSS11F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IEA --
genes like me logo Genes that share ontologies with TMPRSS11F: view

Pathways & Interactions for TMPRSS11F Gene

SuperPathways for TMPRSS11F Gene

No Data Available

Interacting Proteins for TMPRSS11F Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000348639 for TMPRSS11F Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for TMPRSS11F Gene


No data available for Pathways by source and SIGNOR curated interactions for TMPRSS11F Gene

Drugs & Compounds for TMPRSS11F Gene

No Compound Related Data Available

Transcripts for TMPRSS11F Gene

mRNA/cDNA for TMPRSS11F Gene

(2) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMPRSS11F Gene

Transmembrane protease, serine 11F:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMPRSS11F Gene

No ASD Table

Relevant External Links for TMPRSS11F Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMPRSS11F Gene

mRNA expression in normal human tissues for TMPRSS11F Gene

mRNA differential expression in normal tissues according to GTEx for TMPRSS11F Gene

This gene is overexpressed in Esophagus - Mucosa (x19.3), Vagina (x9.0), Skin - Sun Exposed (Lower leg) (x6.3), Skin - Not Sun Exposed (Suprapubic) (x6.0), Minor Salivary Gland (x5.4), and Cervix - Ectocervix (x4.9).

SOURCE GeneReport for Unigene cluster for TMPRSS11F Gene Hs.677557

genes like me logo Genes that share expression patterns with TMPRSS11F: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TMPRSS11F Gene

Orthologs for TMPRSS11F Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMPRSS11F Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TMPRSS11F 35
  • 87.76 (n)
  • 80.83 (a)
  • 79 (a)
(Canis familiaris)
Mammalia TMPRSS11F 35
  • 90.72 (n)
  • 89.5 (a)
  • 89 (a)
(Mus musculus)
Mammalia Tmprss11f 35
  • 85.84 (n)
  • 86.99 (a)
Tmprss11f 16
Tmprss11f 36
  • 87 (a)
(Pan troglodytes)
Mammalia TMPRSS11F 35
  • 99.47 (n)
  • 99.54 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Tmprss11f 35
  • 85.1 (n)
  • 87.1 (a)
(Monodelphis domestica)
Mammalia TMPRSS11F 36
  • 66 (a)
(Ornithorhynchus anatinus)
Mammalia TMPRSS11F 36
  • 69 (a)
(Gallus gallus)
Aves -- 36
  • 43 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 47 (a)
Species with no ortholog for TMPRSS11F:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TMPRSS11F Gene

Gene Tree for TMPRSS11F (if available)
Gene Tree for TMPRSS11F (if available)

Paralogs for TMPRSS11F Gene

genes like me logo Genes that share paralogs with TMPRSS11F: view

Variants for TMPRSS11F Gene

Sequence variations from dbSNP and Humsavar for TMPRSS11F Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs10030708 - 68,129,811(+) TTACG(C/T)GTACA reference, missense
VAR_046636 -
rs961735 -- 68,095,015(+) CAACT(A/G)GCAAA intron-variant
rs961736 -- 68,095,059(+) ATTCA(C/T)GTGAA intron-variant
rs966827 -- 68,096,505(+) TTACT(A/G)CGCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMPRSS11F Gene

Variant ID Type Subtype PubMed ID
nsv879219 CNV Loss 21882294
dgv1625e1 CNV Complex 17122850
esv22957 CNV Gain 19812545
nsv10514 CNV Gain 18304495
esv35010 CNV Gain 17911159
nsv433367 CNV Gain 18776910
nsv818242 CNV Gain 17921354
nsv469718 CNV Gain 16826518
nsv879220 CNV Loss 21882294
nsv879221 CNV Loss 21882294
nsv515010 CNV Complex 21397061
esv273792 CNV Insertion 20981092
esv268503 CNV Insertion 20981092
nsv879222 CNV Loss 21882294

Variation tolerance for TMPRSS11F Gene

Residual Variation Intolerance Score: 85.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.56; 86.06% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TMPRSS11F Gene

Disorders for TMPRSS11F Gene

Relevant External Links for TMPRSS11F

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TMPRSS11F Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMPRSS11F Gene

Publications for TMPRSS11F Gene

  1. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 67

Products for TMPRSS11F Gene

Sources for TMPRSS11F Gene