Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TMPRSS11F Gene

Aliases for TMPRSS11F Gene

  • Transmembrane Protease, Serine 11F 2 3 5
  • Airway Trypsin-Like Protease 4 4
  • EC 61
  • EC 3.4.21.- 4
  • EC 3.4.21 61
  • HATL4 4

External Ids for TMPRSS11F Gene

Previous GeneCards Identifiers for TMPRSS11F Gene

  • GC04M068748
  • GC04M068601
  • GC04M068918
  • GC04M064834

Summaries for TMPRSS11F Gene

GeneCards Summary for TMPRSS11F Gene

TMPRSS11F (Transmembrane Protease, Serine 11F) is a Protein Coding gene. GO annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is TMPRSS11E.

UniProtKB/Swiss-Prot for TMPRSS11F Gene

  • Probable serine protease.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMPRSS11F Gene

Genomics for TMPRSS11F Gene

Regulatory Elements for TMPRSS11F Gene

Enhancers for TMPRSS11F Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04F068074 0.6 ENCODE 10.9 +55.2 55223 0.2 ATF3 CEBPB USF2 EP300 ATF2 TMPRSS11GP TMPRSS11F RNU6-95P LOC100420693 SYT14P1
GH04F068129 1.1 Ensembl ENCODE 0.8 -0.2 -155 0.8 HDAC1 LEF1 CBX3 PKNOX1 TAL1 ZBTB40 GATA3 CTBP1 NCOR1 GATA2 TMPRSS11GP TMPRSS11F FTLP10
GH04F068148 0.6 ENCODE 0.3 -19.1 -19143 1.6 ARID1B SMARCA4 NCOR1 TAL1 ZNF512 ID3 TRIM24 ZNF644 YY1 TMPRSS11BNL TMPRSS11F FTLP10
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMPRSS11F on UCSC Golden Path with GeneCards custom track

Genomic Location for TMPRSS11F Gene

68,053,198 bp from pter
68,129,880 bp from pter
76,683 bases
Minus strand

Genomic View for TMPRSS11F Gene

Genes around TMPRSS11F on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMPRSS11F Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMPRSS11F Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMPRSS11F Gene

Proteins for TMPRSS11F Gene

  • Protein details for TMPRSS11F Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protease serine 11F
    Protein Accession:
    Secondary Accessions:
    • A8MXX2

    Protein attributes for TMPRSS11F Gene

    438 amino acids
    Molecular mass:
    49410 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMPRSS11F Gene

Selected DME Specific Peptides for TMPRSS11F Gene


Post-translational modifications for TMPRSS11F Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMPRSS11F Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for TMPRSS11F Gene

Gene Families for TMPRSS11F Gene

Suggested Antigen Peptide Sequences for TMPRSS11F Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 peptidase S1 domain.
  • Belongs to the peptidase S1 family.
  • Contains 1 peptidase S1 domain.
  • Contains 1 SEA domain.
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with TMPRSS11F: view

Function for TMPRSS11F Gene

Molecular function for TMPRSS11F Gene

UniProtKB/Swiss-Prot Function:
Probable serine protease.

Enzyme Numbers (IUBMB) for TMPRSS11F Gene

Gene Ontology (GO) - Molecular Function for TMPRSS11F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004252 serine-type endopeptidase activity IEA --
GO:0008233 peptidase activity IEA --
GO:0008236 serine-type peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with TMPRSS11F: view
genes like me logo Genes that share phenotypes with TMPRSS11F: view

Animal Model Products

miRNA for TMPRSS11F Gene

miRTarBase miRNAs that target TMPRSS11F

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMPRSS11F Gene

Localization for TMPRSS11F Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMPRSS11F Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMPRSS11F gene
Compartment Confidence
plasma membrane 4
extracellular 2
mitochondrion 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for TMPRSS11F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005887 integral component of plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMPRSS11F: view

Pathways & Interactions for TMPRSS11F Gene

SuperPathways for TMPRSS11F Gene

No Data Available

Interacting Proteins for TMPRSS11F Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: Q6ZWK6-TM11F_HUMAN ENSP00000348639 for TMPRSS11F Gene via IID STRING

Gene Ontology (GO) - Biological Process for TMPRSS11F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with TMPRSS11F: view

No data available for Pathways by source and SIGNOR curated interactions for TMPRSS11F Gene

Transcripts for TMPRSS11F Gene

mRNA/cDNA for TMPRSS11F Gene

(2) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMPRSS11F Gene

Transmembrane protease, serine 11F:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMPRSS11F Gene

No ASD Table

Relevant External Links for TMPRSS11F Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMPRSS11F Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TMPRSS11F Gene

mRNA differential expression in normal tissues according to GTEx for TMPRSS11F Gene

This gene is overexpressed in Esophagus - Mucosa (x19.3), Vagina (x9.0), Skin - Sun Exposed (Lower leg) (x6.3), Skin - Not Sun Exposed (Suprapubic) (x6.0), Minor Salivary Gland (x5.4), and Cervix - Ectocervix (x4.9).

NURSA nuclear receptor signaling pathways regulating expression of TMPRSS11F Gene:


SOURCE GeneReport for Unigene cluster for TMPRSS11F Gene:

genes like me logo Genes that share expression patterns with TMPRSS11F: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for TMPRSS11F Gene

Orthologs for TMPRSS11F Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMPRSS11F Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMPRSS11F 34 35
  • 99.47 (n)
(Canis familiaris)
Mammalia TMPRSS11F 34 35
  • 90.72 (n)
(Bos Taurus)
Mammalia TMPRSS11F 34 35
  • 87.76 (n)
(Mus musculus)
Mammalia Tmprss11f 34 16 35
  • 85.84 (n)
(Rattus norvegicus)
Mammalia Tmprss11f 34
  • 85.1 (n)
(Ornithorhynchus anatinus)
Mammalia TMPRSS11F 35
  • 69 (a)
(Monodelphis domestica)
Mammalia TMPRSS11F 35
  • 66 (a)
(Gallus gallus)
Aves -- 35
  • 43 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 47 (a)
Species where no ortholog for TMPRSS11F was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TMPRSS11F Gene

Gene Tree for TMPRSS11F (if available)
Gene Tree for TMPRSS11F (if available)

Paralogs for TMPRSS11F Gene

Variants for TMPRSS11F Gene

Sequence variations from dbSNP and Humsavar for TMPRSS11F Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs10003334 -- 68,115,994(+) gagtc(C/T)ttcag intron-variant
rs10004522 -- 68,068,588(+) GAAAA(A/G)AAGGC intron-variant
rs10004940 -- 68,091,190(+) AATGT(C/T)TTTCA intron-variant
rs10005543 -- 68,091,755(+) tctct(A/C)tctct intron-variant
rs10007710 -- 68,112,835(+) TTAGT(C/T)TATAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMPRSS11F Gene

Variant ID Type Subtype PubMed ID
esv22957 CNV gain 19812545
esv2759257 CNV gain 17122850
esv3304224 CNV mobile element insertion 20981092
esv3309520 CNV mobile element insertion 20981092
esv3397062 CNV insertion 20981092
esv3427684 CNV insertion 20981092
esv3437728 CNV insertion 20981092
esv35010 CNV gain 17911159
esv3600857 CNV gain 21293372
nsv1007376 CNV gain 25217958
nsv10514 CNV gain 18304495
nsv433367 CNV gain 18776910
nsv469718 CNV gain 16826518
nsv472528 CNV novel sequence insertion 20440878
nsv477505 CNV novel sequence insertion 20440878
nsv515010 CNV loss 21397061
nsv818242 CNV gain 17921354

Variation tolerance for TMPRSS11F Gene

Residual Variation Intolerance Score: 85.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.56; 86.06% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMPRSS11F Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMPRSS11F Gene

Disorders for TMPRSS11F Gene

Relevant External Links for TMPRSS11F

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TMPRSS11F Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMPRSS11F Gene

Publications for TMPRSS11F Gene

  1. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4 64

Products for TMPRSS11F Gene

Sources for TMPRSS11F Gene

Loading form....