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Aliases for TMPRSS11F Gene

Aliases for TMPRSS11F Gene

  • Transmembrane Protease, Serine 11F 2 3
  • Airway Trypsin-Like Protease 4 4
  • EC 63
  • EC 3.4.21.- 4
  • EC 3.4.21 63
  • HATL4 4

External Ids for TMPRSS11F Gene

Previous GeneCards Identifiers for TMPRSS11F Gene

  • GC04M068748
  • GC04M068601
  • GC04M068918
  • GC04M064834

Summaries for TMPRSS11F Gene

GeneCards Summary for TMPRSS11F Gene

TMPRSS11F is a Protein Coding gene. GO annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is HPN.

UniProtKB/Swiss-Prot for TMPRSS11F Gene

  • Probable serine protease.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMPRSS11F Gene

Genomics for TMPRSS11F Gene

Regulatory Elements for TMPRSS11F Gene

Genomic Location for TMPRSS11F Gene

68,053,198 bp from pter
68,129,880 bp from pter
76,683 bases
Minus strand

Genomic View for TMPRSS11F Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMPRSS11F Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMPRSS11F Gene

Proteins for TMPRSS11F Gene

  • Protein details for TMPRSS11F Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protease serine 11F
    Protein Accession:
    Secondary Accessions:
    • A8MXX2

    Protein attributes for TMPRSS11F Gene

    438 amino acids
    Molecular mass:
    49410 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMPRSS11F Gene

Proteomics data for TMPRSS11F Gene at MOPED

Selected DME Specific Peptides for TMPRSS11F Gene

Post-translational modifications for TMPRSS11F Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMPRSS11F Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains for TMPRSS11F Gene

Gene Families for TMPRSS11F Gene

  • TMPRSS :Serine peptidases / Transmembrane

Suggested Antigen Peptide Sequences for TMPRSS11F Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q6ZWK6
  • Contains 1 peptidase S1 domain.
  • Contains 1 SEA domain.
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with TMPRSS11F: view

Function for TMPRSS11F Gene

Molecular function for TMPRSS11F Gene

UniProtKB/Swiss-Prot Function:
Probable serine protease.

Enzyme Numbers (IUBMB) for TMPRSS11F Gene

Gene Ontology (GO) - Molecular Function for TMPRSS11F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004252 serine-type endopeptidase activity IEA --
genes like me logo Genes that share ontologies with TMPRSS11F: view

Phenotypes for TMPRSS11F Gene

GenomeRNAi human phenotypes for TMPRSS11F:
genes like me logo Genes that share phenotypes with TMPRSS11F: view

Animal Model Products

CRISPR Products

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TMPRSS11F Gene

Localization for TMPRSS11F Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMPRSS11F Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

Jensen Localization Image for TMPRSS11F Gene COMPARTMENTS Subcellular localization image for TMPRSS11F gene
Compartment Confidence
extracellular 2
plasma membrane 2
cytosol 1
endoplasmic reticulum 1
golgi apparatus 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for TMPRSS11F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005887 integral component of plasma membrane IEA --
genes like me logo Genes that share ontologies with TMPRSS11F: view

Pathways for TMPRSS11F Gene

SuperPathways for TMPRSS11F Gene

No Data Available

Interacting Proteins for TMPRSS11F Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000348639 for TMPRSS11F Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for TMPRSS11F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with TMPRSS11F: view

No data available for Pathways by source for TMPRSS11F Gene

Transcripts for TMPRSS11F Gene

mRNA/cDNA for TMPRSS11F Gene

(4) Selected AceView cDNA sequences:
(1) Additional mRNA sequences :
(2) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMPRSS11F Gene

Transmembrane protease, serine 11F:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMPRSS11F

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMPRSS11F Gene

No ASD Table

Relevant External Links for TMPRSS11F Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMPRSS11F Gene

mRNA expression in normal human tissues for TMPRSS11F Gene

mRNA differential expression in normal tissues according to GTEx for TMPRSS11F Gene

This gene is overexpressed in Esophagus - Mucosa (19.3), Vagina (9.0), Skin - Sun Exposed (Lower leg) (6.3), Skin - Not Sun Exposed (Suprapubic) (6.0), Minor Salivary Gland (5.4), and Cervix - Ectocervix (4.9).

SOURCE GeneReport for Unigene cluster for TMPRSS11F Gene Hs.677557

genes like me logo Genes that share expressions with TMPRSS11F: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for TMPRSS11F Gene

Orthologs for TMPRSS11F Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMPRSS11F Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TMPRSS11F 35
  • 87.76 (n)
  • 80.83 (a)
  • 79 (a)
(Canis familiaris)
Mammalia TMPRSS11F 35
  • 90.72 (n)
  • 89.5 (a)
  • 89 (a)
(Mus musculus)
Mammalia Tmprss11f 35
  • 85.84 (n)
  • 86.99 (a)
Tmprss11f 16
Tmprss11f 36
  • 87 (a)
(Pan troglodytes)
Mammalia TMPRSS11F 35
  • 99.47 (n)
  • 99.54 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Tmprss11f 35
  • 85.1 (n)
  • 87.1 (a)
(Monodelphis domestica)
Mammalia TMPRSS11F 36
  • 66 (a)
(Ornithorhynchus anatinus)
Mammalia TMPRSS11F 36
  • 69 (a)
(Gallus gallus)
Aves -- 36
  • 43 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 47 (a)
Species with no ortholog for TMPRSS11F:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TMPRSS11F Gene

Gene Tree for TMPRSS11F (if available)
Gene Tree for TMPRSS11F (if available)

Paralogs for TMPRSS11F Gene

genes like me logo Genes that share paralogs with TMPRSS11F: view

Variants for TMPRSS11F Gene

Sequence variations from dbSNP and Humsavar for TMPRSS11F Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs920297 -- 68,078,496(+) ACTGT(C/G)GTAAG intron-variant
rs920298 -- 68,078,536(+) CAATG(C/T)TCCAC intron-variant
rs930386 -- 68,077,021(+) CATAC(A/G)CAGGC intron-variant
rs961735 -- 68,095,015(+) CAACT(A/G)GCAAA intron-variant
rs961736 -- 68,095,059(+) ATTCA(C/T)GTGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMPRSS11F Gene

Variant ID Type Subtype PubMed ID
nsv879219 CNV Loss 21882294
dgv1625e1 CNV Complex 17122850
esv22957 CNV Gain 19812545
nsv10514 CNV Gain 18304495
esv35010 CNV Gain 17911159
nsv433367 CNV Gain 18776910
nsv818242 CNV Gain 17921354
nsv469718 CNV Gain 16826518
nsv879220 CNV Loss 21882294
nsv879221 CNV Loss 21882294
nsv515010 CNV Complex 21397061
esv273792 CNV Insertion 20981092
esv268503 CNV Insertion 20981092
nsv879222 CNV Loss 21882294

Relevant External Links for TMPRSS11F Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMPRSS11F Gene

Disorders for TMPRSS11F Gene

No disorders were found for TMPRSS11F Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for TMPRSS11F Gene

Publications for TMPRSS11F Gene

  1. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4
  3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 4

Products for TMPRSS11F Gene

Sources for TMPRSS11F Gene

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