TMPRSS11F Gene
protein-coding GIFtS: 40
GCID: GC04M068918
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transmembrane protease, serine 11F
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Aliases
for TMPRSS11F gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Transmembrane Protease, Serine 11F1 2 | | EC 3.4.21.-3 | | Airway Trypsin-Like Protease 42 3 | | HATL43 | | FLJ160461 | | EC 3.4.218 | | Transmembrane Protease Serine 11F2 | | EC 3.4.21.428 |
Export aliases for TMPRSS11F gene to outside databasesPrevious GC identifers: GC04M068748 GC04M068601 GC04M064834 |
Summaries
for TMPRSS11F gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: TM11F_HUMAN, Q6ZWK6Function: Probable serine protease (By similarity)
|
Genomic Views
for TMPRSS11F gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000004.11 NC_018915.1 NT_022778.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TMPRSS11F gene promoter:
LHX3b/Lhx3b FOXF2 Brachyury STAT5A CUTL1 Gfi-1 LHX3a/Lhx3a FOXO1a Cart-1 FOXO1
Other transcription factors
Search SABiosciences Chromatin IP Primers for TMPRSS11F
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMPRSS11F |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4q13.2 Ensembl cytogenetic band: 4q13.2 HGNC cytogenetic band: 4q13.2TMPRSS11F Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04M068918: view genomic region
(about GC identifiers)
Start:
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68,918,916 bp from pter |
End:
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68,995,598 bp from pter |
Size:
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76,683 bases |
Orientation:
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minus strand |
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Proteins
for TMPRSS11F gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TM11F_HUMAN, Q6ZWK6 (See
protein sequence)Recommended Name: Transmembrane protease serine 11F Size: 438 amino acids; 49410 Da
Subcellular location: Membrane; Single-pass type II membrane protein (Potential)
Secondary accessions: A8MXX2Explore the universe of human proteins at neXtProt for TMPRSS11F: NX_Q6ZWK6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6ZWK6
4/5 DME Specific Peptides for TMPRSS11F (Q6ZWK6) (see all 5)
TMPRSS11F Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_997290.2
ENSEMBL proteins: ENSP00000348639
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- | | GO:0005887 | integral to plasma membrane |
IEA | -- |
TMPRSS11F for ontologies About GeneDecksing
TMPRSS11F Antibody Products:
Assay Products for TMPRSS11F: |
Protein
Domains /
Families
for TMPRSS11F gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TMPRSS11F for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q6ZWK6ProtoNet protein and cluster: Q6ZWK6 3 Blocks protein families: IPB000082 SEA domain IPB001254 Serine protease IPB001314 Chymotrypsin serine protease family (S1) signature
UniProtKB/Swiss-Prot: TM11F_HUMAN, Q6ZWK6Similarity: Belongs to the peptidase S1 familySimilarity: Contains 1 peptidase S1 domainSimilarity: Contains 1 SEA domain |
Function
for TMPRSS11F gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TM11F_HUMAN, Q6ZWK6Function: Probable serine protease (By similarity)Enzyme Numbers (IUBMB): EC 3.4.212 EC 3.4.21.422 EC 3.4.21.-1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMPRSS11F (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMPRSS11F
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TMPRSS11F (NM_207407) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMPRSS11F | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TMPRSS11F |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMPRSS11F |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004252 | serine-type endopeptidase activity |
IEA | -- |
TMPRSS11F for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for TMPRSS11F:
|
Pathways & Interactions
for TMPRSS11F gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMPRSS11F
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006508 | proteolysis |
IEA | -- |
TMPRSS11F for ontologies About GeneDecksing
|
Drugs & Compounds
for TMPRSS11F gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TMPRSS11F
Search CenterWatch for drugs/clinical trials and news about TMPRSS11F / TM11F
|
Transcripts
for TMPRSS11F gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TMPRSS11F gene: NM_207407.2 Unigene Cluster for TMPRSS11F: Transmembrane protease, serine 11F Hs.677557 [show with all ESTs]Unigene Representative Sequence: AK1226251 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000356291(uc003hdt.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMPRSS11F (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMPRSS11F
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TMPRSS11F (NM_207407) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMPRSS11F | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TMPRSS11F |
Additional cDNA sequence: AK122625.1 1 DOTS entry: DT.91827808 4 AceView cDNA sequences: CA390379 AK122625 NM_207407 BF367386
GeneLoc Exon Structure
|
Expression
for TMPRSS11F gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TMPRSS11F expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTGTGTTGTT
About this image
See TMPRSS11F Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.677557
SABiosciences Custom PCR Arrays for TMPRSS11F
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMPRSS11F
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TMPRSS11F | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMPRSS11F | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMPRSS11F | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMPRSS11F |
Orthologs
for TMPRSS11F gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for TMPRSS11F (if available)
TreeFam Gene Tree for TMPRSS11F (if available) |
Paralogs
for TMPRSS11F gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TMPRSS11F gene
- TMPRSS72 TMPRSS52 ST142 TMPRSS42 TMPRSS11D2 TMPRSS132 TMPRSS11E2 TMPRSS32
- TMPRSS11B2 TMPRSS22 TMPRSS92 HPN2 TMPRSS152 TMPRSS11A2 TMPRSS62
18/75 SIMAP similar genes for TMPRSS11F using alignment to 1 protein entry: TM11F_HUMAN(see all similar genes):HP TMPRSS11B TMPRSS11D TMPRSS11A DESC1 TMPRSS3
F11 HAT MGC52282 PROC1 PRSS22 TMPRSS11E
TMPRSS15 DKFZp586F0824 KLKB1 PROC CELA2A ELA2A
TMPRSS11F for paralogs About GeneDecksing
|
Genomic Variants
for TMPRSS11F gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 9 variations for TMPRSS11F
9 CNVs: 8448 37549 31175 2523 3498 9483 2072 80348 63851 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMPRSS11F |
|
Disorders
/ Diseases
for TMPRSS11F gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for TMPRSS11F gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TMPRSS11F gene integrated from 9 sources:
(articles sorted by number of sources associating them with TMPRSS11F) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
|
External Searches for TMPRSS11F gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing TMPRSS11F gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TMPRSS11F gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TMPRSS11F gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TMPRSS11F | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for TMPRSS11F gene:
Search GeneIP for patents involving TMPRSS11F
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TMPRSS11F gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TMPRSS11F | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMPRSS11F | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMPRSS11F | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TMPRSS11F | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMPRSS11F | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMPRSS11F | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TMPRSS11F | | OriGene Custom Protein Services for TMPRSS11F | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TMPRSS11F | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMPRSS11F | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMPRSS11F | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMPRSS11F | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMPRSS11F | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMPRSS11F |
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 | | | TMPRSS11F Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMPRSS11F |
|  |  |  | | | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TMPRSS11F |
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