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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TMPRSS11F Gene

protein-coding   GIFtS: 40
GCID: GC04M068918

Transmembrane Protease, Serine 11F

  Search for TMPRSS11F
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Transmembrane Protease, Serine 11F1 2     HATL43
Airway Trypsin-Like Protease 42 3     EC 3.4.218
Transmembrane Protease Serine 11F2     EC 3.4.21.428
EC 3.4.21.-3     

External Ids:    HGNC: 299941   Entrez Gene: 3892082   Ensembl: ENSG000001980927   UniProtKB: Q6ZWK63   

Export aliases for TMPRSS11F gene to outside databases

Previous GC identifers: GC04M068748 GC04M068601 GC04M064834


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TMPRSS11F Gene: 
TMPRSS11F (transmembrane protease, serine 11F) is a protein-coding gene. GO annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is TMPRSS11D.

UniProtKB/Swiss-Prot: TM11F_HUMAN, Q6ZWK6
Function: Probable serine protease (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.2  NT_022778.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TMPRSS11F gene promoter:
         LHX3b/Lhx3b   FOXF2   Brachyury   STAT5A   CUTL1   Gfi-1   LHX3a/Lhx3a   FOXO1a   Cart-1   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMPRSS11F promoter sequence
   Search SABiosciences Chromatin IP Primers for TMPRSS11F

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMPRSS11F


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q13.2   Ensembl cytogenetic band:  4q13.2   HGNC cytogenetic band: 4q13.2

TMPRSS11F Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMPRSS11F gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M068918:  view genomic region     (about GC identifiers)

Start:
68,918,916 bp from pter      End:
68,995,598 bp from pter
Size:
76,683 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TM11F_HUMAN, Q6ZWK6 (See protein sequence)
Recommended Name: Transmembrane protease serine 11F  
Size: 438 amino acids; 49410 Da
Subcellular location: Membrane; Single-pass type II membrane protein (Potential)
Secondary accessions: A8MXX2

Explore the universe of human proteins at neXtProt for TMPRSS11F: NX_Q6ZWK6

Explore proteomics data for TMPRSS11F at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6ZWK6

  • 4/5 DME Specific Peptides for TMPRSS11F (Q6ZWK6) (see all 5)
     GDSGGPL  WIASKTG  CKGDSGG  DIALVQL 

    TMPRSS11F Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TMPRSS11F Protein Expression
    REFSEQ proteins: NP_997290.2  
    ENSEMBL proteins: 
     ENSP00000348639  

    Human Recombinant Protein Products for TMPRSS11F: 
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    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005887integral to plasma membrane IEA--

    TMPRSS11F for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    TMPRSS: Serine peptidases / Transmembrane

    5/6 InterPro protein domains (see all 6):
     IPR001314 Peptidase_S1A
     IPR000082 SEA_dom
     IPR017329 Pept_S1A_HAT/DESC1
     IPR009003 Trypsin-like_Pept_dom
     IPR001254 Peptidase_S1

    Graphical View of Domain Structure for InterPro Entry Q6ZWK6

    ProtoNet protein and cluster: Q6ZWK6

    3 Blocks protein domains:
    IPB000082 SEA domain
    IPB001254 Serine protease
    IPB001314 Chymotrypsin serine protease family (S1) signature


    UniProtKB/Swiss-Prot: TM11F_HUMAN, Q6ZWK6
    Similarity: Belongs to the peptidase S1 family
    Similarity: Contains 1 peptidase S1 domain
    Similarity: Contains 1 SEA domain


    TMPRSS11F for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TM11F_HUMAN, Q6ZWK6
    Function: Probable serine protease (By similarity)

         Enzyme Numbers (IUBMB): EC 3.4.212 EC 3.4.21.422 EC 3.4.21.-1

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004252serine-type endopeptidase activity IEA--
         
    TMPRSS11F for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for TMPRSS11F:
     High actin ratio cells 

    Animal Models:
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TMPRSS11F 
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    SwitchGear 3'UTR luciferase reporter plasmidTMPRSS11F 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMPRSS11F

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IEA--

    TMPRSS11F for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    EMD Millipore small molecules for TMPRSS11F:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TMPRSS11F (TM11F)

    Search CenterWatch for drugs/clinical trials and news about TMPRSS11F / TM11F

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TMPRSS11F gene: 
    NM_207407.2  

    Unigene Cluster for TMPRSS11F:

    Transmembrane protease, serine 11F
    Hs.677557  [show with all ESTs]
    Unigene Representative Sequence: AK122625
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000356291(uc003hdt.1)
    miRNA
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    6 QIAGEN miScript miRNA Assays for microRNAs that regulate TMPRSS11F:
    hsa-miR-31 hsa-miR-136 hsa-miR-489 hsa-miR-516a-3p hsa-miR-3662 hsa-miR-516b*
    SwitchGear 3'UTR luciferase reporter plasmidTMPRSS11F 3' UTR sequence
    Inhib. RNA
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    Primer
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    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TMPRSS11F
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMPRSS11F
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMPRSS11F

    Additional mRNA sequence: AK122625.1 

    1 DOTS entry:

    DT.91827808 

    4 AceView cDNA sequences:

    CA390379 AK122625 NM_207407 BF367386 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TMPRSS11F expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGTGTTGTT
    TMPRSS11F Expression
    About this image


    See TMPRSS11F Protein Expression from SPIRE MOPED and PaxDB
    SOURCE GeneReport for Unigene cluster: Hs.677557
        SABiosciences Custom PCR Arrays for TMPRSS11F
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMPRSS11F

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for TMPRSS11F gene from 2/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tmprss11f1 , 5 transmembrane protease, serine 11f1, 5 85.84(n)1
    86.99(a)1
      5 (43.56 cM)5
    2430831  NM_178730.31  NP_848845.11 
     865218985 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    10(a)
    possible ortholog
    GL343765.1(146281-196748)


    ENSEMBL Gene Tree for TMPRSS11F (if available)
    TreeFam Gene Tree for TMPRSS11F (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TMPRSS11F gene
    TMPRSS11D2  TMPRSS32  TMPRSS11B2  TMPRSS62  TMPRSS11A2  TMPRSS72  TMPRSS52  TMPRSS42  
    ST142  TMPRSS132  TMPRSS11E2  TMPRSS22  KLKB12  F112  HPN2  TMPRSS152  
    18/76 SIMAP similar genes for TMPRSS11F using alignment to 1 protein entry:     TM11F_HUMAN(see all similar genes):
    HP    TMPRSS11B    TMPRSS11D    TMPRSS11A    DESC1    TMPRSS3
    F11    HAT    MGC52282    PROC1    PRSS22    TMPRSS11E
    TMPRSS15    DKFZp586F0824    KLKB1    PROC    CELA2A    ELA2A

    TMPRSS11F for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1227 SNPs in TMPRSS11F are shown (see all 1227)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0466364
    ----see VAR_0466362 D N mis40--------
    rs746151351,2
    C,F--68939491(+) CACCTT/CACGAC 1 -- int11Minor allele frequency- C:0.05EA 120
    rs1809379031,2
    --68939605(+) GTTCAA/TCAAAT 1 -- int10--------
    rs1432739181,2
    F--68939686(+) TTGATA/GAATCG 2 F syn11Minor allele frequency- G:0.00NA 3786
    rs2003594891,2
    --68939690(+) TAAATC/TGACCG 2 Q R mis10--------
    rs1995597431,2
    C--68939693(+) ATCGAA/CCGCCT 2 G V mis10--------
    rs1998435971,2
    --68939786(+) AATAA-/TTTTTT 1 -- int10--------
    rs755519931,2
    C,F--68940033(+) TTGATT/GTGAGA 1 -- int11Minor allele frequency- G:0.13WA 118
    rs13708291,2
    C,F--68940060(+) TCACAC/TATTTT 1 -- int116Minor allele frequency- T:0.04NA EA WA CSA 632
    rs800893301,2
    F--68940198(+) CATCCC/AAAATA 1 -- int11Minor allele frequency- A:0.04WA 118

    HapMap Linkage Disequilibrium report for TMPRSS11F (68918916 - 68995598 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/14 variations for TMPRSS11F (see all 14):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv273792CNV Insertion20981092
    esv268503CNV Insertion20981092
    nsv879219CNV Loss21882294
    nsv879222CNV Loss21882294
    nsv879221CNV Loss21882294
    nsv879220CNV Loss21882294
    esv35010CNV Gain17911159
    nsv10514CNV Gain18304495
    nsv469718CNV Gain16826518
    nsv818242CNV Gain17921354

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TMPRSS11F gene integrated from 9 sources:
    (articles sorted by number of sources associating them with TMPRSS11F)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 389208 HGNC: 29994 AceView: FLJ16046 Ensembl:ENSG00000198092 euGenes: HUgn389208
    ECgene: TMPRSS11F H-InvDB: TMPRSS11F

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TMPRSS11F Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TMPRSS11F gene:
    Search GeneIP for patents involving TMPRSS11F

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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