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Aliases for TMPRSS11E Gene

Aliases for TMPRSS11E Gene

  • Transmembrane Protease, Serine 11E 2 3 5
  • Transmembrane Protease Serine 11E2 3 4
  • Serine Protease DESC1 3 4
  • TMPRSS11E2 3 4
  • DESC1 3 4
  • Transmembrane Protease, Serine 11E2 2
  • Transmembrane Protease Serine 11E 3
  • EC 3.4.21.1 61
  • EC 3.4.21.- 4
  • EC 3.4.21 61

External Ids for TMPRSS11E Gene

Previous HGNC Symbols for TMPRSS11E Gene

  • TMPRSS11E2

Previous GeneCards Identifiers for TMPRSS11E Gene

  • GC04P069142
  • GC04P068995
  • GC04P069313
  • GC04P065226

Summaries for TMPRSS11E Gene

GeneCards Summary for TMPRSS11E Gene

TMPRSS11E (Transmembrane Protease, Serine 11E) is a Protein Coding gene. GO annotations related to this gene include serine-type endopeptidase activity and serine-type peptidase activity. An important paralog of this gene is TMPRSS11F.

UniProtKB/Swiss-Prot for TMPRSS11E Gene

  • Serine protease which possesses both gelatinolytic and caseinolytic activities. Shows a preference for Arg in the P1 position.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMPRSS11E Gene

Genomics for TMPRSS11E Gene

Regulatory Elements for TMPRSS11E Gene

Enhancers for TMPRSS11E Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04F068731 1.3 FANTOM5 ENCODE 10.2 +286.8 286816 5.9 ATF1 MLX ARID4B ZNF48 YY1 SP5 MIER2 PPARG KAT8 SSRP1 LOC100422026 TMPRSS11E UGT2A3 UGT2B7 ENSG00000272626 UGT2B10 UGT2B11 UGT2B15 LOC728811
GH04F068403 0.9 Ensembl ENCODE 11.9 -41.7 -41727 4.8 BRD4 PAF1 TEAD4 CEBPB POLR2A BCL11A POU5F1 KDM1A TMPRSS11E TMPRSS11GP MT2P1
GH04F068408 0.7 Ensembl ENCODE 11.2 -37.2 -37223 3.5 POLR2A HLF FOS TMPRSS11E MT2P1
GH04F068396 0.4 ENCODE 11.9 -49.4 -49398 3.1 HLF TMPRSS11E TMPRSS11BNL MT2P1
GH04F068494 0.4 Ensembl 10.1 +47.4 47352 0.4 HLF UGT2B17 TMPRSS11E UGT2B29P GC04P068452
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMPRSS11E on UCSC Golden Path with GeneCards custom track

Genomic Location for TMPRSS11E Gene

Chromosome:
4
Start:
68,447,449 bp from pter
End:
68,497,604 bp from pter
Size:
50,156 bases
Orientation:
Plus strand

Genomic View for TMPRSS11E Gene

Genes around TMPRSS11E on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMPRSS11E Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMPRSS11E Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMPRSS11E Gene

Proteins for TMPRSS11E Gene

  • Protein details for TMPRSS11E Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UL52-TM11E_HUMAN
    Recommended name:
    Transmembrane protease serine 11E
    Protein Accession:
    Q9UL52
    Secondary Accessions:
    • A6NL71
    • Q14DC8
    • Q6UW31

    Protein attributes for TMPRSS11E Gene

    Size:
    423 amino acids
    Molecular mass:
    47696 Da
    Quaternary structure:
    • Forms a heterodimer with SERPINA5 and SERPINE1.

    Three dimensional structures from OCA and Proteopedia for TMPRSS11E Gene

neXtProt entry for TMPRSS11E Gene

Selected DME Specific Peptides for TMPRSS11E Gene

Q9UL52:
  • DACQGDSGG
  • GDSGGPL
  • GSHRCGA
  • PNKPGVY
  • TPRMLCAG
  • CQGDSGGP

Post-translational modifications for TMPRSS11E Gene

Other Protein References for TMPRSS11E Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for TMPRSS11E Gene

Gene Families for TMPRSS11E Gene

Suggested Antigen Peptide Sequences for TMPRSS11E Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UL52

UniProtKB/Swiss-Prot:

TM11E_HUMAN :
  • Contains 1 peptidase S1 domain.
  • Belongs to the peptidase S1 family.
Domain:
  • Contains 1 peptidase S1 domain.
  • Contains 1 SEA domain.
Family:
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with TMPRSS11E: view

Function for TMPRSS11E Gene

Molecular function for TMPRSS11E Gene

UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by SERPINA5.
UniProtKB/Swiss-Prot Function:
Serine protease which possesses both gelatinolytic and caseinolytic activities. Shows a preference for Arg in the P1 position.

Enzyme Numbers (IUBMB) for TMPRSS11E Gene

Gene Ontology (GO) - Molecular Function for TMPRSS11E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004252 serine-type endopeptidase activity IEA --
GO:0008233 peptidase activity IEA --
GO:0008236 serine-type peptidase activity ISS --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with TMPRSS11E: view

Phenotypes for TMPRSS11E Gene

genes like me logo Genes that share phenotypes with TMPRSS11E: view

Animal Model Products

miRNA for TMPRSS11E Gene

miRTarBase miRNAs that target TMPRSS11E

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMPRSS11E Gene

Localization for TMPRSS11E Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMPRSS11E Gene

Cell membrane; Single-pass type II membrane protein.
Transmembrane protease serine 11E catalytic chain: Secreted. Note=Activated by cleavage and secreted. {ECO:0000250 UniProtKB:Q5S248}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMPRSS11E gene
Compartment Confidence
plasma membrane 5
extracellular 4
endoplasmic reticulum 2
golgi apparatus 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TMPRSS11E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane IEA --
GO:0005887 integral component of plasma membrane ISS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMPRSS11E: view

Pathways & Interactions for TMPRSS11E Gene

SuperPathways for TMPRSS11E Gene

No Data Available

Interacting Proteins for TMPRSS11E Gene

Gene Ontology (GO) - Biological Process for TMPRSS11E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis ISS --
GO:0050890 cognition IMP 23227193
genes like me logo Genes that share ontologies with TMPRSS11E: view

No data available for Pathways by source and SIGNOR curated interactions for TMPRSS11E Gene

Transcripts for TMPRSS11E Gene

mRNA/cDNA for TMPRSS11E Gene

(2) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(13) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMPRSS11E Gene

Transmembrane protease, serine 11E:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMPRSS11E Gene

No ASD Table

Relevant External Links for TMPRSS11E Gene

GeneLoc Exon Structure for
TMPRSS11E
ECgene alternative splicing isoforms for
TMPRSS11E

Expression for TMPRSS11E Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TMPRSS11E Gene

mRNA differential expression in normal tissues according to GTEx for TMPRSS11E Gene

This gene is overexpressed in Esophagus - Mucosa (x22.7), Vagina (x14.8), Cervix - Ectocervix (x8.8), and Minor Salivary Gland (x4.8).

Protein differential expression in normal tissues from HIPED for TMPRSS11E Gene

This gene is overexpressed in Saliva (32.3) and Cervix (29.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TMPRSS11E Gene



Protein tissue co-expression partners for TMPRSS11E Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TMPRSS11E Gene:

TMPRSS11E

SOURCE GeneReport for Unigene cluster for TMPRSS11E Gene:

Hs.201877

mRNA Expression by UniProt/SwissProt for TMPRSS11E Gene:

Q9UL52-TM11E_HUMAN
Tissue specificity: Expression can only be detected in tissues derived from the head and neck, and in skin, prostate and testis.
genes like me logo Genes that share expression patterns with TMPRSS11E: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for TMPRSS11E Gene

Orthologs for TMPRSS11E Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMPRSS11E Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMPRSS11E 34 35
  • 99.37 (n)
dog
(Canis familiaris)
Mammalia TMPRSS11E 34 35
  • 87.6 (n)
cow
(Bos Taurus)
Mammalia TMPRSS11E 34
  • 86.65 (n)
-- 35
  • 42 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Tmprss11e 34 16 35
  • 80.96 (n)
rat
(Rattus norvegicus)
Mammalia Tmprss11e 34
  • 80.96 (n)
oppossum
(Monodelphis domestica)
Mammalia TMPRSS11E 35
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMPRSS11E 35
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMPRSS11F 34
  • 58.44 (n)
-- 35
  • 43 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 46 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101732637 34
  • 56.09 (n)
Species where no ortholog for TMPRSS11E was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TMPRSS11E Gene

ENSEMBL:
Gene Tree for TMPRSS11E (if available)
TreeFam:
Gene Tree for TMPRSS11E (if available)

Paralogs for TMPRSS11E Gene

Variants for TMPRSS11E Gene

Sequence variations from dbSNP and Humsavar for TMPRSS11E Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs10020631 -- 68,488,145(+) aggat(A/G)ggtgt intron-variant
rs1026340 -- 68,477,825(-) AGTAG(G/T)AGCAA intron-variant
rs1026341 -- 68,477,635(-) TCCGA(C/T)GCTCA intron-variant
rs1037496 -- 68,472,241(-) TATGA(A/C)CCAGC intron-variant
rs1037497 -- 68,472,041(-) GGTGA(A/G)AAGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMPRSS11E Gene

Variant ID Type Subtype PubMed ID
nsv442910 CNV loss 18776908
nsv1161106 CNV deletion 26073780
nsv1122086 CNV deletion 24896259
nsv1119004 CNV deletion 24896259
nsv1119003 CNV deletion 24896259
nsv1119002 CNV deletion 24896259
nsv1073769 CNV deletion 25765185
nsv10515 CNV gain 18304495
nsv1004012 CNV gain 25217958
esv3893944 CNV gain+loss 25118596
esv3584805 CNV loss 24956385
esv3584804 CNV loss 24956385
esv3584514 CNV gain 24956385
esv2763805 CNV loss 21179565
esv2759258 CNV gain+loss 17122850
dgv9102n54 CNV gain 21841781
dgv88n17 CNV loss 16327808
dgv5254n100 CNV gain 25217958
dgv5253n100 CNV gain 25217958
dgv5251n100 CNV gain 25217958
dgv5250n100 CNV gain+loss 25217958
dgv5249n100 CNV gain 25217958
dgv5248n100 CNV gain 25217958
dgv5247n100 CNV loss 25217958
dgv5246n100 CNV loss 25217958
dgv5243n100 CNV gain 25217958
dgv5242n100 CNV gain 25217958
dgv49e213 CNV gain 24956385
dgv1490e212 CNV gain 25503493

Variation tolerance for TMPRSS11E Gene

Residual Variation Intolerance Score: 29.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.23; 84.97% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMPRSS11E Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMPRSS11E

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMPRSS11E Gene

Disorders for TMPRSS11E Gene

Relevant External Links for TMPRSS11E

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMPRSS11E

No disorders were found for TMPRSS11E Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMPRSS11E Gene

Publications for TMPRSS11E Gene

  1. Crystal structure of the catalytic domain of DESC1, a new member of the type II transmembrane serine proteinase family. (PMID: 17388811) Kyrieleis O.J. … Jacob U. (FEBS J. 2007) 3 4 64
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4 64
  3. Mouse DESC1 is located within a cluster of seven DESC1-like genes and encodes a type II transmembrane serine protease that forms serpin inhibitory complexes. (PMID: 15328353) Hobson J.P. … Bugge T.H. (J. Biol. Chem. 2004) 2 3 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64

Products for TMPRSS11E Gene

Sources for TMPRSS11E Gene

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