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Aliases for TMPRSS11E Gene

Aliases for TMPRSS11E Gene

  • Transmembrane Protease, Serine 11E 2 3 5
  • Transmembrane Protease, Serine 11E2 2 3
  • Transmembrane Protease Serine 11E2 3 4
  • Serine Protease DESC1 3 4
  • TMPRSS11E2 3 4
  • DESC1 3 4
  • EC 63
  • EC 3.4.21.- 4
  • EC 3.4.21 63

External Ids for TMPRSS11E Gene

Previous HGNC Symbols for TMPRSS11E Gene

  • TMPRSS11E2

Previous GeneCards Identifiers for TMPRSS11E Gene

  • GC04P069142
  • GC04P068995
  • GC04P069313
  • GC04P065226

Summaries for TMPRSS11E Gene

GeneCards Summary for TMPRSS11E Gene

TMPRSS11E (Transmembrane Protease, Serine 11E) is a Protein Coding gene. GO annotations related to this gene include serine-type endopeptidase activity and serine-type peptidase activity. An important paralog of this gene is TMPRSS11A.

UniProtKB/Swiss-Prot for TMPRSS11E Gene

  • Serine protease which possesses both gelatinolytic and caseinolytic activities. Shows a preference for Arg in the P1 position.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMPRSS11E Gene

Genomics for TMPRSS11E Gene

Regulatory Elements for TMPRSS11E Gene

Enhancers for TMPRSS11E Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TMPRSS11E on UCSC Golden Path with GeneCards custom track

Genomic Location for TMPRSS11E Gene

68,447,449 bp from pter
68,497,604 bp from pter
50,156 bases
Plus strand

Genomic View for TMPRSS11E Gene

Genes around TMPRSS11E on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMPRSS11E Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMPRSS11E Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMPRSS11E Gene

Proteins for TMPRSS11E Gene

  • Protein details for TMPRSS11E Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protease serine 11E
    Protein Accession:
    Secondary Accessions:
    • A6NL71
    • Q14DC8
    • Q6UW31

    Protein attributes for TMPRSS11E Gene

    423 amino acids
    Molecular mass:
    47696 Da
    Quaternary structure:
    • Forms a heterodimer with SERPINA5 and SERPINE1.

    Three dimensional structures from OCA and Proteopedia for TMPRSS11E Gene

neXtProt entry for TMPRSS11E Gene

Proteomics data for TMPRSS11E Gene at MOPED

Selected DME Specific Peptides for TMPRSS11E Gene

Post-translational modifications for TMPRSS11E Gene

Other Protein References for TMPRSS11E Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for TMPRSS11E Gene

Gene Families for TMPRSS11E Gene

Suggested Antigen Peptide Sequences for TMPRSS11E Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 peptidase S1 domain.
  • Belongs to the peptidase S1 family.
  • Contains 1 peptidase S1 domain.
  • Contains 1 SEA domain.
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with TMPRSS11E: view

Function for TMPRSS11E Gene

Molecular function for TMPRSS11E Gene

UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by SERPINA5.
UniProtKB/Swiss-Prot Function:
Serine protease which possesses both gelatinolytic and caseinolytic activities. Shows a preference for Arg in the P1 position.

Enzyme Numbers (IUBMB) for TMPRSS11E Gene

Phenotypes for TMPRSS11E Gene

genes like me logo Genes that share phenotypes with TMPRSS11E: view

Animal Model Products

CRISPR Products

miRNA for TMPRSS11E Gene

miRTarBase miRNAs that target TMPRSS11E

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMPRSS11E Gene

Localization for TMPRSS11E Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMPRSS11E Gene

Cell membrane; Single-pass type II membrane protein.
Transmembrane protease serine 11E catalytic chain: Secreted. Note=Activated by cleavage and secreted. {ECO:0000250 UniProtKB:Q5S248}.

Subcellular locations from

Jensen Localization Image for TMPRSS11E Gene COMPARTMENTS Subcellular localization image for TMPRSS11E gene
Compartment Confidence
plasma membrane 5
extracellular 4
endoplasmic reticulum 2
golgi apparatus 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TMPRSS11E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IEA,ISS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMPRSS11E: view

Pathways & Interactions for TMPRSS11E Gene

SuperPathways for TMPRSS11E Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMPRSS11E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050890 cognition IMP 23227193
genes like me logo Genes that share ontologies with TMPRSS11E: view

No data available for Pathways by source and SIGNOR curated interactions for TMPRSS11E Gene

Drugs & Compounds for TMPRSS11E Gene

No Compound Related Data Available

Transcripts for TMPRSS11E Gene

mRNA/cDNA for TMPRSS11E Gene

(3) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(13) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMPRSS11E Gene

Transmembrane protease, serine 11E:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMPRSS11E Gene

No ASD Table

Relevant External Links for TMPRSS11E Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMPRSS11E Gene

mRNA expression in normal human tissues for TMPRSS11E Gene

mRNA differential expression in normal tissues according to GTEx for TMPRSS11E Gene

This gene is overexpressed in Esophagus - Mucosa (x22.7), Vagina (x14.8), Cervix - Ectocervix (x8.8), and Minor Salivary Gland (x4.8).

Protein differential expression in normal tissues from HIPED for TMPRSS11E Gene

This gene is overexpressed in Saliva (32.3) and Cervix (29.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TMPRSS11E Gene

SOURCE GeneReport for Unigene cluster for TMPRSS11E Gene Hs.201877

mRNA Expression by UniProt/SwissProt for TMPRSS11E Gene

Tissue specificity: Expression can only be detected in tissues derived from the head and neck, and in skin, prostate and testis.
genes like me logo Genes that share expression patterns with TMPRSS11E: view

Protein tissue co-expression partners for TMPRSS11E Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for TMPRSS11E Gene

Orthologs for TMPRSS11E Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMPRSS11E Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TMPRSS11E 35
  • 86.65 (n)
  • 81.28 (a)
-- 36
  • 42 (a)
(Canis familiaris)
Mammalia TMPRSS11E 35
  • 87.6 (n)
  • 83.18 (a)
  • 83 (a)
(Mus musculus)
Mammalia Tmprss11e 35
  • 80.96 (n)
  • 75.83 (a)
Tmprss11e 16
Tmprss11e 36
  • 76 (a)
(Pan troglodytes)
Mammalia TMPRSS11E 35
  • 99.37 (n)
  • 99.05 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Tmprss11e 35
  • 80.96 (n)
  • 75.36 (a)
(Monodelphis domestica)
Mammalia TMPRSS11E 36
  • 70 (a)
(Ornithorhynchus anatinus)
Mammalia TMPRSS11E 36
  • 63 (a)
(Gallus gallus)
Aves TMPRSS11F 35
  • 58.44 (n)
  • 48.15 (a)
-- 36
  • 43 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 46 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101732637 35
  • 56.09 (n)
  • 47.83 (a)
Species with no ortholog for TMPRSS11E:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TMPRSS11E Gene

Gene Tree for TMPRSS11E (if available)
Gene Tree for TMPRSS11E (if available)

Paralogs for TMPRSS11E Gene Pseudogenes for TMPRSS11E Gene

genes like me logo Genes that share paralogs with TMPRSS11E: view

Variants for TMPRSS11E Gene

Sequence variations from dbSNP and Humsavar for TMPRSS11E Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs976002 - 68,477,569(-) ACTCA(C/T)AGGAT reference, missense
rs976058 -- 68,475,769(-) CCACT(A/G)TAGAT intron-variant
rs983745 -- 68,476,451(-) TCAAG(C/G/T)TTCAA intron-variant
rs984808 -- 68,480,191(-) tgacc(A/G)aaaat intron-variant
rs955292 -- 68,491,796(-) CATTT(A/T)ATGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMPRSS11E Gene

Variant ID Type Subtype PubMed ID
dgv1626e1 CNV Complex 17122850
dgv1628e1 CNV Complex 17122850
dgv88n17 CNV Loss 16327808
dgv5580n71 CNV Loss 21882294
essv23402 CNV CNV 17122850
dgv1629e1 CNV Complex 17122850
dgv5581n71 CNV Loss 21882294
nsv879230 CNV Gain 21882294
nsv10515 CNV Gain 18304495
dgv5582n71 CNV Gain 21882294
dgv5583n71 CNV Gain 21882294
dgv5584n71 CNV Loss 21882294
nsv442910 CNV CNV 18776908
dgv5585n71 CNV Gain 21882294

Variation tolerance for TMPRSS11E Gene

Residual Variation Intolerance Score: 29.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.23; 84.97% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TMPRSS11E Gene

Disorders for TMPRSS11E Gene

Relevant External Links for TMPRSS11E

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TMPRSS11E Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMPRSS11E Gene

Publications for TMPRSS11E Gene

  1. Crystal structure of the catalytic domain of DESC1, a new member of the type II transmembrane serine proteinase family. (PMID: 17388811) Kyrieleis O.J. … Jacob U. (FEBS J. 2007) 3 4 67
  2. Mouse DESC1 is located within a cluster of seven DESC1-like genes and encodes a type II transmembrane serine protease that forms serpin inhibitory complexes. (PMID: 15328353) Hobson J.P. … Bugge T.H. (J. Biol. Chem. 2004) 2 3
  3. DESC1 and MSPL activate influenza A viruses and emerging coronaviruses for host cell entry. (PMID: 25122802) Zmora P. … Bertram S. (J. Virol. 2014) 3
  4. Analysis of copy number variation in Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals. (PMID: 23227193) Swaminathan S. … Saykin A.J. (PLoS ONE 2012) 3
  5. Human DESC1 serine protease confers tumorigenic properties to MDCK cells and it is upregulated in tumours of different origin. (PMID: 17579619) Viloria C.G. … Cal S. (Br. J. Cancer 2007) 23

Products for TMPRSS11E Gene

Sources for TMPRSS11E Gene