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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TMPRSS11E Gene

protein-coding   GIFtS: 46
GCID: GC04P069313

transmembrane protease, serine 11E

(Previous names: transmembrane protease, serine 11E2 )
(Previous symbol: TMPRSS11E2)
 Explore 5 diseases affiliated with
TMPRSS11E via our new
 Human Malady Compendium 
Biological research products
for TMPRSS11E
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Transmembrane Protease, Serine 11E1 2     Transmembrane Protease Serine 11E22 3
DESC11 2 3     Transmembrane Protease Serine 11E2
TMPRSS11E21 2 3     EC 3.4.21.-3
Transmembrane Protease, Serine 11E21 2     EC 3.4.218
Serine Protease DESC12 3     EC 3.4.21.18

External Ids:    HGNC: 244651   Entrez Gene: 289832   Ensembl: ENSG000000871287   OMIM: 6103995   UniProtKB: Q9UL523   

Export aliases for TMPRSS11E gene to outside databases

Previous GC identifers: GC04P069142 GC04P068995 GC04P065226


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: TM11E_HUMAN, Q9UL52
Function: Serine protease which possesses both gelatinolytic and caseinolytic activities. Shows a preference for Arg in
the P1 position (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_022778.16  NT_167250.1  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for TMPRSS11E
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMPRSS11E promoter sequence
   Search SABiosciences Chromatin IP Primers for TMPRSS11E

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMPRSS11E


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q13.2   Ensembl cytogenetic band:  4q13.2   HGNC cytogenetic band: 4q13.2

TMPRSS11E Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMPRSS11E gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P069313:  view genomic region     (about GC identifiers)

Start:
69,313,167 bp from pter      End:
69,363,322 bp from pter
Size:
50,156 bases      Orientation:
plus strand

1 alternative location:
Chr4+,ALT_REF_LOCI_8 69,372,001-69,422,153     

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TM11E_HUMAN, Q9UL52 (See protein sequence)
Recommended Name: Transmembrane protease serine 11E precursor  
Size: 423 amino acids; 47696 Da
Subunit: Forms a heterodimer with SERPINA5 and SERPINE1
Subcellular location: Cell membrane; Single-pass type II membrane protein (By similarity)
Subcellular location: Transmembrane protease serine 11E catalytic chain: Secreted (By similarity). Note=Activated by
cleavage and secreted (By similarity)
Caution: It is uncertain whether Met-1 or Met-2 is the initiator
1 PDB 3D structure from and Proteopedia for TMPRSS11E:
2OQ5 (3D)    
Secondary accessions: A6NL71 Q14DC8 Q6UW31

Explore the universe of human proteins at neXtProt for TMPRSS11E: NX_Q9UL52

Post-translational modifications:

  • N-glycosylated (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9UL52

  • 4/6 DME Specific Peptides for TMPRSS11E (Q9UL52) (see all 6)
     GDSGGPL  GSHRCGA  PNKPGVY  CQGDSGGP 

    TMPRSS11E Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_054777.2  
    ENSEMBL proteins: 
     ENSP00000307519   ENSP00000424109  

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    Uscn Proteins for TMPRSS11E

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005886plasma membrane ----
    GO:0005887integral to plasma membrane ISS--


    TMPRSS11E for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TMPRSS11E for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR001314 Peptidase_S1A
     IPR000082 SEA
     IPR017329 Pept_S1A_HAT/DESC1
     IPR009003 Trypsin-like_Pept_dom
     IPR001254 Peptidase_S1

    Graphical View of Domain Structure for InterPro Entry Q9UL52

    ProtoNet protein and cluster: Q9UL52

    3 Blocks protein families:
    IPB000082 SEA domain
    IPB001254 Serine protease
    IPB001314 Chymotrypsin serine protease family (S1) signature


    UniProtKB/Swiss-Prot: TM11E_HUMAN, Q9UL52
    Similarity: Belongs to the peptidase S1 family
    Similarity: Contains 1 peptidase S1 domain
    Similarity: Contains 1 SEA domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: TM11E_HUMAN, Q9UL52
    Function: Serine protease which possesses both gelatinolytic and caseinolytic activities. Shows a preference for Arg in
    the P1 position (By similarity)
    Enzyme regulation: Inhibited by SERPINA5

    Enzyme Numbers (IUBMB): EC 3.4.212 EC 3.4.21.12 EC 3.4.21.-1

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    Inhib. RNA
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004252serine-type endopeptidase activity IEA--
    GO:0005515protein binding ----
    GO:0008236serine-type peptidase activity ISS--


    TMPRSS11E for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMPRSS11E

    2 Interacting proteins for TMPRSS11E (Q9UL523) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SERPINA5P051543I2D: score=1 
    SERPINE1P051213I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis ISS--


    TMPRSS11E for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TMPRSS11E
    Search CenterWatch for drugs/clinical trials and news about TMPRSS11E / TM11E 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TMPRSS11E gene: 
    NM_014058.3  

    Unigene Cluster for TMPRSS11E:

    Transmembrane protease, serine 11E
    Hs.201877  [show with all ESTs]
    Unigene Representative Sequence: NM_014058
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000305363(uc003hdz.4) ENST00000510647

    miRNA
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    3 QIAGEN miScript miRNA Assays for microRNAs that regulate TMPRSS11E:
    hsa-miR-505 hsa-miR-489 hsa-miR-944
    SwitchGear 3'UTR luciferase reporter plasmidTMPRSS11E 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMPRSS11E
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    Additional cDNA sequence: 

    AF064819.1 AK292787.1 AK313859.1 AY359017.1 BC113412.1 BC113414.1 

    4 DOTS entries:

    DT.65288155  DT.121256157  DT.121240407  DT.121240411 

    13 AceView cDNA sequences:

    BG680862 AF064819 NM_014058 AY359017 AL698811 AI282714 AI696187 BE181019 
    BG204874 BG193269 BE711113 BG207680 CD702243 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TMPRSS11E expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See TMPRSS11E Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TMPRSS11E

    SOURCE GeneReport for Unigene cluster: Hs.201877

    UniProtKB/Swiss-Prot: TM11E_HUMAN, Q9UL52
    Tissue specificity: Expression can only be detected in tissues derived from the head and neck, and in skin, prostate
    and testis

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMPRSS11E

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for TMPRSS11E gene from 2/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves TMPRSS11E1 transmembrane protease, serine 11E 58.46(n)
    48.77(a)
      771454  XM_001234737.1  XP_001234738.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    45(a)
    1 ↔ 1
    6(58399564-58428267)


    ENSEMBL Gene Tree for TMPRSS11E (if available)
    TreeFam Gene Tree for TMPRSS11E (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TMPRSS11E gene
    TMPRSS72  TMPRSS52  ST142  TMPRSS42  TMPRSS11D2  TMPRSS132  TMPRSS32  TMPRSS11B2  
    TMPRSS22  TMPRSS92  HPN2  TMPRSS152  TMPRSS11F2  TMPRSS11A2  TMPRSS62  
    18/56 SIMAP similar genes for TMPRSS11E using alignment to 2 protein entries:     TM11E_HUMAN (see all proteins) (see all similar genes):
    DESC1    TMPRSS11A    TMPRSS11D    TMPRSS11F    ST14    TMPRSS2
    PRSS22    CELA2A    TMPRSS11B    TMPRSS15    TMPRSS7    TMPRSS5
    PRSS42    CTRB1    CTRB2    DKFZp586F0824    HPN    PRSS41

    TMPRSS11E for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for TMPRSS11E
    PGOHUM00000245555


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for TMPRSS11E
         4 CNVs: 38138 3499 92177 31176
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TMPRSS11E for disorders           About GeneDecksing

    OMIM gene information: 610399    OMIM disorders: --

    5 diseases for TMPRSS11E:    About MalaCards
    squamous cell carcinoma of the head and neck    squamous cell carcinoma    renal cell carcinoma    carcinoma
    prostatitis


    Export disorders for TMPRSS11E gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TMPRSS11E gene, integrated from 9 sources (see all 12):
    (articles sorted by number of sources associating them with TMPRSS11E)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Crystal structure of the catalytic domain of DESC1, a new member of the type II transmembrane serine proteinase family. (PubMed id 17388811)1, 2 Kyrieleis O.J....Jacob U. (2007)
    2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Mouse DESC1 is located within a cluster of seven DESC1-like genes and encodes a type II transmembrane serine protease that forms serpin inhibitory complexes. (PubMed id 15328353)1, 3 Hobson J.P....Bugge T.H. (2004)
    5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    6. Differential expression of a novel serine protease homologue in squamous cell carcinoma of the head and neck. (PubMed id 11161383)1, 2 Lang J.C. and Schuller D.E. (2001)
    7. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    8. Regulation of carcinoma cell invasion by protein C inhibitor whose expression is decreased in renal cell carcinoma. (PubMed id 14696115)2 Wakita T....Suzuki K. (2004)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    10. Toward a complete human genome sequence. (PubMed id 9847074)1 Wilson R. (1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 28983 HGNC: 24465 AceView: DESC1 Ensembl:ENSG00000087128 euGenes: HUgn28983
    ECgene: TMPRSS11E H-InvDB: TMPRSS11E

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TMPRSS11E Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TMPRSS11E gene:
    Search GeneIP for patents involving TMPRSS11E

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
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    About This Section

     
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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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    VWF
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    von Willebrand factor
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