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Aliases for TMPRSS11E Gene

Aliases for TMPRSS11E Gene

  • DESC1 3 4 6
  • Transmembrane Protease, Serine 11E2 2 3
  • Transmembrane Protease, Serine 11E 2 3
  • Transmembrane Protease Serine 11E2 3 4
  • Serine Protease DESC1 3 4
  • TMPRSS11E2 3 4
  • Transmembrane Protease Serine 11E 3
  • EC 63
  • EC 3.4.21.- 4
  • EC 3.4.21 63

External Ids for TMPRSS11E Gene

Previous HGNC Symbols for TMPRSS11E Gene

  • TMPRSS11E2

Previous GeneCards Identifiers for TMPRSS11E Gene

  • GC04P069142
  • GC04P068995
  • GC04P069313
  • GC04P065226

Summaries for TMPRSS11E Gene

GeneCards Summary for TMPRSS11E Gene

TMPRSS11E is a Protein Coding gene. GO annotations related to this gene include serine-type endopeptidase activity and serine-type peptidase activity. An important paralog of this gene is HPN.

UniProtKB/Swiss-Prot for TMPRSS11E Gene

  • Serine protease which possesses both gelatinolytic and caseinolytic activities. Shows a preference for Arg in the P1 position (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMPRSS11E Gene

Genomics for TMPRSS11E Gene

Genomic Location for TMPRSS11E Gene

68,447,449 bp from pter
68,497,604 bp from pter
50,156 bases
Plus strand

Genomic View for TMPRSS11E Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMPRSS11E Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMPRSS11E Gene

No data available for Regulatory Elements for TMPRSS11E Gene

Proteins for TMPRSS11E Gene

  • Protein details for TMPRSS11E Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protease serine 11E
    Protein Accession:
    Secondary Accessions:
    • A6NL71
    • Q14DC8
    • Q6UW31

    Protein attributes for TMPRSS11E Gene

    423 amino acids
    Molecular mass:
    47696 Da
    Quaternary structure:
    • Forms a heterodimer with SERPINA5 and SERPINE1

    Three dimensional structures from OCA and Proteopedia for TMPRSS11E Gene

neXtProt entry for TMPRSS11E Gene

Proteomics data for TMPRSS11E Gene at MOPED

Selected DME Specific Peptides for TMPRSS11E Gene

Post-translational modifications for TMPRSS11E Gene

Other Protein References for TMPRSS11E Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains for TMPRSS11E Gene

Gene Families for TMPRSS11E Gene

  • TMPRSS :Serine peptidases / Transmembrane

Suggested Antigen Peptide Sequences for TMPRSS11E Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9UL52
  • Contains 1 peptidase S1 domain.
  • Contains 1 SEA domain.
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with TMPRSS11E: view

Function for TMPRSS11E Gene

Molecular function for TMPRSS11E Gene

UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by SERPINA5.
UniProtKB/Swiss-Prot Function:
Serine protease which possesses both gelatinolytic and caseinolytic activities. Shows a preference for Arg in the P1 position (By similarity).

Enzyme Numbers (IUBMB) for TMPRSS11E Gene

Gene Ontology (GO) - Molecular Function for TMPRSS11E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004252 serine-type endopeptidase activity IEA --
GO:0005515 protein binding --
GO:0008236 serine-type peptidase activity ISS --
genes like me logo Genes that share ontologies with TMPRSS11E: view

Animal Model Products

CRISPR Products

miRNA for TMPRSS11E Gene

miRTarBase miRNAs that target TMPRSS11E

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMPRSS11E

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TMPRSS11E Gene

Localization for TMPRSS11E Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMPRSS11E Gene

Cell membrane; Single-pass type II membrane protein.
Transmembrane protease serine 11E catalytic chain: Secreted. Note=Activated by cleavage and secreted. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for TMPRSS11E Gene COMPARTMENTS Subcellular localization image for TMPRSS11E gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 2
extracellular 2
golgi apparatus 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TMPRSS11E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane --
GO:0005887 integral component of plasma membrane ISS --
genes like me logo Genes that share ontologies with TMPRSS11E: view

Pathways for TMPRSS11E Gene

SuperPathways for TMPRSS11E Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMPRSS11E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis ISS --
GO:0050890 cognition IMP 23227193
genes like me logo Genes that share ontologies with TMPRSS11E: view

No data available for Pathways by source for TMPRSS11E Gene

Transcripts for TMPRSS11E Gene

mRNA/cDNA for TMPRSS11E Gene

(13) Selected AceView cDNA sequences:
(3) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMPRSS11E Gene

Transmembrane protease, serine 11E:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMPRSS11E

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMPRSS11E Gene

No ASD Table

Relevant External Links for TMPRSS11E Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMPRSS11E Gene

mRNA expression in normal human tissues for TMPRSS11E Gene

mRNA differential expression in normal tissues according to GTEx for TMPRSS11E Gene

This gene is overexpressed in Esophagus - Mucosa (22.7), Vagina (14.8), Cervix - Ectocervix (8.8), and Minor Salivary Gland (4.8).

Protein differential expression in normal tissues for TMPRSS11E Gene

This gene is overexpressed in Saliva (32.3) and Cervix (29.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TMPRSS11E Gene

SOURCE GeneReport for Unigene cluster for TMPRSS11E Gene Hs.201877

mRNA Expression by UniProt/SwissProt for TMPRSS11E Gene

Tissue specificity: Expression can only be detected in tissues derived from the head and neck, and in skin, prostate and testis.
genes like me logo Genes that share expressions with TMPRSS11E: view

Expression partners for TMPRSS11E Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for TMPRSS11E Gene

Orthologs for TMPRSS11E Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMPRSS11E Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TMPRSS11E 35
  • 86.65 (n)
  • 81.28 (a)
-- 36
  • 42 (a)
(Canis familiaris)
Mammalia TMPRSS11E 35
  • 87.6 (n)
  • 83.18 (a)
  • 83 (a)
(Mus musculus)
Mammalia Tmprss11e 35
  • 80.96 (n)
  • 75.83 (a)
Tmprss11e 16
Tmprss11e 36
  • 76 (a)
(Pan troglodytes)
Mammalia TMPRSS11E 35
  • 99.37 (n)
  • 99.05 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Tmprss11e 35
  • 80.96 (n)
  • 75.36 (a)
(Monodelphis domestica)
Mammalia TMPRSS11E 36
  • 70 (a)
(Ornithorhynchus anatinus)
Mammalia TMPRSS11E 36
  • 63 (a)
(Gallus gallus)
Aves TMPRSS11F 35
  • 58.44 (n)
  • 48.15 (a)
-- 36
  • 43 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 46 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101732637 35
  • 56.09 (n)
  • 47.83 (a)
Species with no ortholog for TMPRSS11E:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TMPRSS11E Gene

Gene Tree for TMPRSS11E (if available)
Gene Tree for TMPRSS11E (if available)

Paralogs for TMPRSS11E Gene Pseudogenes for TMPRSS11E Gene

genes like me logo Genes that share paralogs with TMPRSS11E: view

Variants for TMPRSS11E Gene

Sequence variations from dbSNP and Humsavar for TMPRSS11E Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs955292 -- 68,491,796(-) CATTT(A/T)ATGAA intron-variant
rs955909 -- 68,463,987(-) TATGA(C/G)TAAGA intron-variant
rs955962 -- 68,464,703(+) TTGAC(C/T)TGTAC intron-variant
rs955963 -- 68,464,809(+) TTAAT(A/G)TGTGA intron-variant
rs959510 -- 68,491,855(-) AAAGC(A/T)TGAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMPRSS11E Gene

Variant ID Type Subtype PubMed ID
dgv1626e1 CNV Complex 17122850
dgv1628e1 CNV Complex 17122850
dgv88n17 CNV Loss 16327808
dgv5580n71 CNV Loss 21882294
essv23402 CNV CNV 17122850
dgv1629e1 CNV Complex 17122850
dgv5581n71 CNV Loss 21882294
nsv879230 CNV Gain 21882294
nsv10515 CNV Gain 18304495
dgv5582n71 CNV Gain 21882294
dgv5583n71 CNV Gain 21882294
dgv5584n71 CNV Loss 21882294
nsv442910 CNV CNV 18776908
dgv5585n71 CNV Gain 21882294

Relevant External Links for TMPRSS11E Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMPRSS11E Gene

Disorders for TMPRSS11E Gene

No disorders were found for TMPRSS11E Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for TMPRSS11E Gene

Publications for TMPRSS11E Gene

  1. Differential expression of a novel serine protease homologue in squamous cell carcinoma of the head and neck. (PMID: 11161383) Lang J.C. … Schuller D.E. (Br. J. Cancer 2001) 3 4
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  3. Mouse DESC1 is located within a cluster of seven DESC1-like genes and encodes a type II transmembrane serine protease that forms serpin inhibitory complexes. (PMID: 15328353) Hobson J.P. … Bugge T.H. (J. Biol. Chem. 2004) 2 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4

Products for TMPRSS11E Gene

Sources for TMPRSS11E Gene

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