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Aliases for TMPRSS11D Gene

Aliases for TMPRSS11D Gene

  • Transmembrane Protease, Serine 11D 2 3
  • Airway Trypsin Like Protease 2 3
  • Airway Trypsin-Like Protease 3 4
  • HAT 3 4
  • EC 3.4.21.- 4
  • EC 3.4.21 63

External Ids for TMPRSS11D Gene

Previous GeneCards Identifiers for TMPRSS11D Gene

  • GC04M068518
  • GC04M068369
  • GC04M068686
  • GC04M064599

Summaries for TMPRSS11D Gene

Entrez Gene Summary for TMPRSS11D Gene

  • This gene encodes a trypsin-like serine protease released from the submucosal serous glands onto mucous membrane. It is a type II integral membrane protein and has 29-38% identity in the sequence of the catalytic region with human hepsin, enteropeptidase, acrosin, and mast cell tryptase. The noncatalytic region has little similarity to other known proteins. This protein may play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions. [provided by RefSeq, Jul 2008]

GeneCards Summary for TMPRSS11D Gene

TMPRSS11D (Transmembrane Protease, Serine 11D) is a Protein Coding gene. GO annotations related to this gene include serine-type endopeptidase activity and peptidase activity. An important paralog of this gene is HPN.

UniProtKB/Swiss-Prot for TMPRSS11D Gene

  • May play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions. Plays a role in the proteolytic processing of ACE2. Proteolytically cleaves and activates the human coronavirus 229E (HCoV-229E) spike glycoprotein which facilitate virus-cell membrane fusions; spike proteins are synthesized and maintained in precursor intermediate folding states and proteolysis permits the refolding and energy release required to create stable virus-cell linkages and membrane coalescence.

Gene Wiki entry for TMPRSS11D Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMPRSS11D Gene

Genomics for TMPRSS11D Gene

Regulatory Elements for TMPRSS11D Gene

Genomic Location for TMPRSS11D Gene

Chromosome:
4
Start:
67,820,876 bp from pter
End:
67,884,032 bp from pter
Size:
63,157 bases
Orientation:
Minus strand

Genomic View for TMPRSS11D Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMPRSS11D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMPRSS11D Gene

Proteins for TMPRSS11D Gene

  • Protein details for TMPRSS11D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60235-TM11D_HUMAN
    Recommended name:
    Transmembrane protease serine 11D
    Protein Accession:
    O60235
    Secondary Accessions:
    • Q08AF6

    Protein attributes for TMPRSS11D Gene

    Size:
    418 amino acids
    Molecular mass:
    46263 Da
    Quaternary structure:
    • Monomer

neXtProt entry for TMPRSS11D Gene

Proteomics data for TMPRSS11D Gene at MOPED

Selected DME Specific Peptides for TMPRSS11D Gene

Post-translational modifications for TMPRSS11D Gene

Other Protein References for TMPRSS11D Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for TMPRSS11D (Airway Trypsin-like Protease/HAT)

Domains & Families for TMPRSS11D Gene

Gene Families for TMPRSS11D Gene

Suggested Antigen Peptide Sequences for TMPRSS11D Gene

Graphical View of Domain Structure for InterPro Entry

O60235

UniProtKB/Swiss-Prot:

TM11D_HUMAN :
  • Contains 1 peptidase S1 domain.
  • Belongs to the peptidase S1 family.
Domain:
  • Contains 1 peptidase S1 domain.
  • Contains 1 SEA domain.
Family:
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with TMPRSS11D: view

Function for TMPRSS11D Gene

Molecular function for TMPRSS11D Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Preferentially cleaves the C-terminal side of arginine residues at the P1 position of certain peptides, cleaving Boc-Phe-Ser-Arg-4-methylcoumaryl-7-amide most efficiently and having an optimum pH of 8.6 with this substrate
UniProtKB/Swiss-Prot EnzymeRegulation:
Strongly inhibited by diisopropyl fluorophosphate, leupeptin, antipain, aprotinin, and soybean trypsin inhibitor, but hardly inhibited by secretory leukocyte protease inhibitor at 10 microM
UniProtKB/Swiss-Prot Function:
May play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions. Plays a role in the proteolytic processing of ACE2. Proteolytically cleaves and activates the human coronavirus 229E (HCoV-229E) spike glycoprotein which facilitate virus-cell membrane fusions; spike proteins are synthesized and maintained in precursor intermediate folding states and proteolysis permits the refolding and energy release required to create stable virus-cell linkages and membrane coalescence.

Enzyme Numbers (IUBMB) for TMPRSS11D Gene

Gene Ontology (GO) - Molecular Function for TMPRSS11D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004252 serine-type endopeptidase activity IEA --
GO:0008233 peptidase activity TAS 9565616
genes like me logo Genes that share ontologies with TMPRSS11D: view
genes like me logo Genes that share phenotypes with TMPRSS11D: view

Animal Model Products

CRISPR Products

miRNA for TMPRSS11D Gene

miRTarBase miRNAs that target TMPRSS11D

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMPRSS11D

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for TMPRSS11D Gene

Localization for TMPRSS11D Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMPRSS11D Gene

Cell membrane; Single-pass type II membrane protein. Note=Activated by cleavage and secreted.
Transmembrane protease serine 11D catalytic chain: Secreted. Note=Activated by cleavage and secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMPRSS11D Gene COMPARTMENTS Subcellular localization image for TMPRSS11D gene
Compartment Confidence
extracellular 5
plasma membrane 5
nucleus 1

Gene Ontology (GO) - Cellular Components for TMPRSS11D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS 9565616
GO:0005887 integral component of plasma membrane IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with TMPRSS11D: view

Pathways & Interactions for TMPRSS11D Gene

SuperPathways for TMPRSS11D Gene

No Data Available

Interacting Proteins for TMPRSS11D Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000283916%0d%0a9606.ENSP00000414287%0d%0a9606.ENSP00000225728%0d%0a
Selected Interacting proteins: O60235-TM11D_HUMAN ENSP00000283916 for TMPRSS11D Gene via MINT STRING

Gene Ontology (GO) - Biological Process for TMPRSS11D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IDA 24227843
GO:0007585 respiratory gaseous exchange TAS 9565616
genes like me logo Genes that share ontologies with TMPRSS11D: view

No data available for Pathways by source and SIGNOR curated interactions for TMPRSS11D Gene

Drugs & Compounds for TMPRSS11D Gene

(4) Drugs for TMPRSS11D Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Aprotinin Approved, Withdrawn Pharma Inhibitor of bovine pancreatic trypsin 24
arginine Nutra 346
Calcium Nutra 0
serine Nutra 420

(5) Additional Compounds for TMPRSS11D Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
FIBRINOGEN
HATPA
Leupeptin
Mitozolomide
O6-Benzylguanine
genes like me logo Genes that share compounds with TMPRSS11D: view

Transcripts for TMPRSS11D Gene

Unigene Clusters for TMPRSS11D Gene

Transmembrane protease, serine 11D:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMPRSS11D

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMPRSS11D Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b
SP1: - -
SP2:
SP3: - - - - -
SP4:

Relevant External Links for TMPRSS11D Gene

GeneLoc Exon Structure for
TMPRSS11D
ECgene alternative splicing isoforms for
TMPRSS11D

Expression for TMPRSS11D Gene

mRNA expression in normal human tissues for TMPRSS11D Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMPRSS11D Gene

This gene is overexpressed in Esophagus - Mucosa (x17.9), Vagina (x16.7), Cervix - Ectocervix (x12.3), and Minor Salivary Gland (x5.7).

Protein differential expression in normal tissues from HIPED for TMPRSS11D Gene

This gene is overexpressed in Nasal epithelium (35.7) and Cervix (23.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TMPRSS11D Gene



SOURCE GeneReport for Unigene cluster for TMPRSS11D Gene Hs.132195

mRNA Expression by UniProt/SwissProt for TMPRSS11D Gene

O60235-TM11D_HUMAN
Tissue specificity: Located in the cells of the submucosal serous glands of the bronchi and trachea
genes like me logo Genes that share expression patterns with TMPRSS11D: view

Protein tissue co-expression partners for TMPRSS11D Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for TMPRSS11D Gene

This gene was present in the common ancestor of animals.

Orthologs for TMPRSS11D Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TMPRSS11D 35
  • 81.37 (n)
  • 70.98 (a)
TMPRSS11D 36
  • 71 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMPRSS11D 35
  • 85.02 (n)
  • 78.61 (a)
TMPRSS11D 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmprss11d 35
  • 75.86 (n)
  • 66.67 (a)
Tmprss11d 16
Tmprss11d 36
  • 66 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TMPRSS11D 35
  • 99.44 (n)
  • 99.04 (a)
TMPRSS11D 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmprss11d 35
  • 75.94 (n)
  • 67.39 (a)
oppossum
(Monodelphis domestica)
Mammalia TMPRSS11D 36
  • 58 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMPRSS11D 36
  • 53 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 36
  • 52 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 48 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012842 35
  • 47.17 (n)
  • 43.4 (a)
Species with no ortholog for TMPRSS11D:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TMPRSS11D Gene

ENSEMBL:
Gene Tree for TMPRSS11D (if available)
TreeFam:
Gene Tree for TMPRSS11D (if available)

Paralogs for TMPRSS11D Gene

genes like me logo Genes that share paralogs with TMPRSS11D: view

Variants for TMPRSS11D Gene

Structural Variations from Database of Genomic Variants (DGV) for TMPRSS11D Gene

Variant ID Type Subtype PubMed ID
nsv879214 CNV Gain 21882294
nsv829960 CNV Loss 17160897
nsv879219 CNV Loss 21882294

Variation tolerance for TMPRSS11D Gene

Residual Variation Intolerance Score: 22.14% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.01; 20.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMPRSS11D Gene

HapMap Linkage Disequilibrium report
TMPRSS11D

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for TMPRSS11D Gene

Disorders for TMPRSS11D Gene

Relevant External Links for TMPRSS11D

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMPRSS11D
genes like me logo Genes that share disorders with TMPRSS11D: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMPRSS11D Gene

Publications for TMPRSS11D Gene

  1. Large-scale discovery of insertion hotspots and preferential integration sites of human transposed elements. (PMID: 20008508) Levy A. … Ast G. (Nucleic Acids Res. 2010) 23 67
  2. Gene therapy vectors: the prospects and potentials of the cut-and-paste transposons. (PMID: 19649713) Claeys Bouuaert C. … Chalmers R.M. (Genetica 2010) 23 67
  3. hAT transposable elements and their derivatives: an analysis in the 12 Drosophila genomes. (PMID: 20127503) de Freitas Ortiz M. … Loreto E.L. (Genetica 2010) 23 67
  4. Cleavage of influenza virus hemagglutinin by airway proteases TMPRSS2 and HAT differs in subcellular localization and susceptibility to protease inhibitors. (PMID: 20237084) BAPttcher-FriebertshAouser E. … Garten W. (J. Virol. 2010) 23 67
  5. Transcriptional activity of rice autonomous transposable element Dart. (PMID: 19410335) Fujino K. … Sekiguchi H. (J. Plant Physiol. 2009) 23 67

Products for TMPRSS11D Gene

Sources for TMPRSS11D Gene

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