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Aliases for TMPRSS11D Gene

Aliases for TMPRSS11D Gene

  • Transmembrane Protease, Serine 11D 2 3
  • Airway Trypsin Like Protease 2 3
  • Airway Trypsin-Like Protease 3 4
  • HAT 3 4
  • Transmembrane Protease Serine 11D 3
  • EC 3.4.21.- 4
  • EC 3.4.21 63

External Ids for TMPRSS11D Gene

Previous GeneCards Identifiers for TMPRSS11D Gene

  • GC04M068518
  • GC04M068369
  • GC04M068686
  • GC04M064599

Summaries for TMPRSS11D Gene

Entrez Gene Summary for TMPRSS11D Gene

  • This gene encodes a trypsin-like serine protease released from the submucosal serous glands onto mucous membrane. It is a type II integral membrane protein and has 29-38% identity in the sequence of the catalytic region with human hepsin, enteropeptidase, acrosin, and mast cell tryptase. The noncatalytic region has little similarity to other known proteins. This protein may play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions. [provided by RefSeq, Jul 2008]

GeneCards Summary for TMPRSS11D Gene

TMPRSS11D is a Protein Coding gene. Diseases associated with TMPRSS11D include brain stem glioma. GO annotations related to this gene include serine-type endopeptidase activity and peptidase activity. An important paralog of this gene is HPN.

UniProtKB/Swiss-Prot for TMPRSS11D Gene

  • May play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions. Plays a role in the proteolytic processing of ACE2. Proteolytically cleaves and activates the human coronavirus 229E (HCoV-229E) spike glycoprotein which facilitate virus-cell membrane fusions; spike proteins are synthesized and maintained in precursor intermediate folding states and proteolysis permits the refolding and energy release required to create stable virus-cell linkages and membrane coalescence.

Gene Wiki entry for TMPRSS11D Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMPRSS11D Gene

Genomics for TMPRSS11D Gene

Regulatory Elements for TMPRSS11D Gene

Genomic Location for TMPRSS11D Gene

Start:
67,820,876 bp from pter
End:
67,884,032 bp from pter
Size:
63,157 bases
Orientation:
Minus strand

Genomic View for TMPRSS11D Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMPRSS11D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMPRSS11D Gene

Proteins for TMPRSS11D Gene

  • Protein details for TMPRSS11D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60235-TM11D_HUMAN
    Recommended name:
    Transmembrane protease serine 11D
    Protein Accession:
    O60235
    Secondary Accessions:
    • Q08AF6

    Protein attributes for TMPRSS11D Gene

    Size:
    418 amino acids
    Molecular mass:
    46263 Da
    Quaternary structure:
    • Monomer

neXtProt entry for TMPRSS11D Gene

Proteomics data for TMPRSS11D Gene at MOPED

Selected DME Specific Peptides for TMPRSS11D Gene

Post-translational modifications for TMPRSS11D Gene

No Post-translational modifications

Other Protein References for TMPRSS11D Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for TMPRSS11D (Airway Trypsin-like Protease/HAT)

Domains for TMPRSS11D Gene

Gene Families for TMPRSS11D Gene

HGNC:
  • TMPRSS :Serine peptidases / Transmembrane

Suggested Antigen Peptide Sequences for TMPRSS11D Gene

Graphical View of Domain Structure for InterPro Entry

O60235

UniProtKB/Swiss-Prot:

TM11D_HUMAN :
  • O60235
Domain:
  • Contains 1 peptidase S1 domain.
  • Contains 1 SEA domain.
Family:
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with TMPRSS11D: view

Function for TMPRSS11D Gene

Molecular function for TMPRSS11D Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Preferentially cleaves the C-terminal side of arginine residues at the P1 position of certain peptides, cleaving Boc-Phe-Ser-Arg-4-methylcoumaryl-7-amide most efficiently and having an optimum pH of 8.6 with this substrate
UniProtKB/Swiss-Prot EnzymeRegulation:
Strongly inhibited by diisopropyl fluorophosphate, leupeptin, antipain, aprotinin, and soybean trypsin inhibitor, but hardly inhibited by secretory leukocyte protease inhibitor at 10 microM
UniProtKB/Swiss-Prot Function:
May play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions. Plays a role in the proteolytic processing of ACE2. Proteolytically cleaves and activates the human coronavirus 229E (HCoV-229E) spike glycoprotein which facilitate virus-cell membrane fusions; spike proteins are synthesized and maintained in precursor intermediate folding states and proteolysis permits the refolding and energy release required to create stable virus-cell linkages and membrane coalescence.

Enzyme Numbers (IUBMB) for TMPRSS11D Gene

Gene Ontology (GO) - Molecular Function for TMPRSS11D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004252 serine-type endopeptidase activity IEA --
GO:0008233 peptidase activity TAS 9565616
genes like me logo Genes that share ontologies with TMPRSS11D: view

Phenotypes for TMPRSS11D Gene

MGI mutant phenotypes for TMPRSS11D:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with TMPRSS11D: view

Animal Model Products

CRISPR Products

miRNA for TMPRSS11D Gene

miRTarBase miRNAs that target TMPRSS11D

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMPRSS11D

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for TMPRSS11D Gene

Localization for TMPRSS11D Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMPRSS11D Gene

Cell membrane; Single-pass type II membrane protein. Note=Activated by cleavage and secreted.
Transmembrane protease serine 11D catalytic chain: Secreted. Note=Activated by cleavage and secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMPRSS11D Gene COMPARTMENTS Subcellular localization image for TMPRSS11D gene
Compartment Confidence
extracellular 5
plasma membrane 5
golgi apparatus 2
nucleus 2
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for TMPRSS11D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS 9565616
GO:0005887 integral component of plasma membrane IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with TMPRSS11D: view

Pathways for TMPRSS11D Gene

SuperPathways for TMPRSS11D Gene

No Data Available

Interacting Proteins for TMPRSS11D Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000283916%0d%0a9606.ENSP00000414287%0d%0a9606.ENSP00000225728%0d%0a
Selected Interacting proteins: O60235-TM11D_HUMAN ENSP00000283916 for TMPRSS11D Gene via MINT STRING

Gene Ontology (GO) - Biological Process for TMPRSS11D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IDA 24227843
GO:0007585 respiratory gaseous exchange TAS 9565616
genes like me logo Genes that share ontologies with TMPRSS11D: view

No data available for Pathways by source for TMPRSS11D Gene

Compounds for TMPRSS11D Gene

(9) Novoseek inferred chemical compound relationships for TMPRSS11D Gene

Compound -log(P) Hits PubMed IDs
hatpa 92.1 3
mitozolomide 87.5 5
o6-benzylguanine 69.5 7
leupeptin 64.1 3
serine 35.8 9
genes like me logo Genes that share compounds with TMPRSS11D: view

Transcripts for TMPRSS11D Gene

Unigene Clusters for TMPRSS11D Gene

Transmembrane protease, serine 11D:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMPRSS11D

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMPRSS11D Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b
SP1: - -
SP2:
SP3: - - - - -
SP4:

Relevant External Links for TMPRSS11D Gene

GeneLoc Exon Structure for
TMPRSS11D
ECgene alternative splicing isoforms for
TMPRSS11D

Expression for TMPRSS11D Gene

mRNA expression in normal human tissues for TMPRSS11D Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMPRSS11D Gene

This gene is overexpressed in Esophagus - Mucosa (17.9), Vagina (16.7), Cervix - Ectocervix (12.3), and Minor Salivary Gland (5.7).

Protein differential expression in normal tissues for TMPRSS11D Gene

This gene is overexpressed in Nasal epithelium (35.7) and Cervix (23.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TMPRSS11D Gene

SOURCE GeneReport for Unigene cluster for TMPRSS11D Gene Hs.132195

mRNA Expression by UniProt/SwissProt for TMPRSS11D Gene

O60235-TM11D_HUMAN
Tissue specificity: Located in the cells of the submucosal serous glands of the bronchi and trachea
genes like me logo Genes that share expressions with TMPRSS11D: view

Expression partners for TMPRSS11D Gene

In Situ Assay Products

Orthologs for TMPRSS11D Gene

This gene was present in the common ancestor of animals.

Orthologs for TMPRSS11D Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TMPRSS11D 35
  • 81.37 (n)
  • 70.98 (a)
TMPRSS11D 36
  • 71 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMPRSS11D 35
  • 85.02 (n)
  • 78.61 (a)
TMPRSS11D 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmprss11d 35
  • 75.86 (n)
  • 66.67 (a)
Tmprss11d 16
Tmprss11d 36
  • 66 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TMPRSS11D 35
  • 99.44 (n)
  • 99.04 (a)
TMPRSS11D 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmprss11d 35
  • 75.94 (n)
  • 67.39 (a)
oppossum
(Monodelphis domestica)
Mammalia TMPRSS11D 36
  • 58 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMPRSS11D 36
  • 53 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 36
  • 52 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 48 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012842 35
  • 47.17 (n)
  • 43.4 (a)
Species with no ortholog for TMPRSS11D:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TMPRSS11D Gene

ENSEMBL:
Gene Tree for TMPRSS11D (if available)
TreeFam:
Gene Tree for TMPRSS11D (if available)

Paralogs for TMPRSS11D Gene

genes like me logo Genes that share paralogs with TMPRSS11D: view

Variants for TMPRSS11D Gene

Sequence variations from dbSNP and Humsavar for TMPRSS11D Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs718591 -- 67,850,747(-) ACACA(C/T)GCAAG intron-variant
rs730258 -- 67,882,952(-) TCATG(C/T)AATAG intron-variant
rs894017 -- 67,827,765(-) GAATA(C/G)AAAAA intron-variant
rs894018 -- 67,883,080(-) CAAAA(G/T)TCAAA intron-variant
rs960994 -- 67,884,691(-) TATAT(C/T)CTGCT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TMPRSS11D Gene

Variant ID Type Subtype PubMed ID
nsv879214 CNV Gain 21882294
nsv829960 CNV Loss 17160897
nsv879219 CNV Loss 21882294

Relevant External Links for TMPRSS11D Gene

HapMap Linkage Disequilibrium report
TMPRSS11D

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMPRSS11D Gene

Disorders for TMPRSS11D Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for TMPRSS11D Gene in MalaCards »

(1) Diseases for TMPRSS11D Gene including...

(1) University of Copenhagen DISEASES for TMPRSS11D Gene

(2) Novoseek inferred disease relationships for TMPRSS11D Gene

Disease -log(P) Hits PubMed IDs
airways disease 61.5 6
bronchitis chronic 31.5 1
genes like me logo Genes that share disorders with TMPRSS11D: view

No data available for OMIM , UniProtKB/Swiss-Prot , Genatlas and External Links for TMPRSS11D Gene

Publications for TMPRSS11D Gene

  1. Purification, characterization, and localization of a novel trypsin- like protease found in the human airway. (PMID: 9070615) Yasuoka S. … Sano T. (Am. J. Respir. Cell Mol. Biol. 1997) 2 3 4
  2. Cloning and characterization of the cDNA for human airway trypsin- like protease. (PMID: 9565616) Yamaoka K. … Yasuoka S. (J. Biol. Chem. 1998) 2 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Effect of human airway trypsin-like protease on intracellular free Ca2+ concentration in human bronchial epithelial cells. (PMID: 12630574) Miki M. … Sone S. (J. Med. Invest. 2003) 3 23
  5. Localization of human airway trypsin-like protease in the airway: an immunohistochemical study. (PMID: 11326745) Takahashi M. … Yasuoka S. (Histochem. Cell Biol. 2001) 3 23

Products for TMPRSS11D Gene

Sources for TMPRSS11D Gene

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