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Aliases for TMPRSS11D Gene

Aliases for TMPRSS11D Gene

  • Transmembrane Protease, Serine 11D 2 3 5
  • Airway Trypsin-Like Protease 3 4
  • HAT 3 4
  • Transmembrane Protease Serine 11D 3
  • Airway Trypsin Like Protease 2
  • EC 3.4.21.- 4
  • EC 3.4.21 61

External Ids for TMPRSS11D Gene

Previous GeneCards Identifiers for TMPRSS11D Gene

  • GC04M068518
  • GC04M068369
  • GC04M068686
  • GC04M064599

Summaries for TMPRSS11D Gene

Entrez Gene Summary for TMPRSS11D Gene

  • This gene encodes a trypsin-like serine protease released from the submucosal serous glands onto mucous membrane. It is a type II integral membrane protein and has 29-38% identity in the sequence of the catalytic region with human hepsin, enteropeptidase, acrosin, and mast cell tryptase. The noncatalytic region has little similarity to other known proteins. This protein may play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions. [provided by RefSeq, Jul 2008]

GeneCards Summary for TMPRSS11D Gene

TMPRSS11D (Transmembrane Protease, Serine 11D) is a Protein Coding gene. Diseases associated with TMPRSS11D include Brain Stem Cancer and Brain Stem Glioma. GO annotations related to this gene include serine-type endopeptidase activity and peptidase activity. An important paralog of this gene is TMPRSS11F.

UniProtKB/Swiss-Prot for TMPRSS11D Gene

  • May play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions. Plays a role in the proteolytic processing of ACE2. Proteolytically cleaves and activates the human coronavirus 229E (HCoV-229E) spike glycoprotein which facilitate virus-cell membrane fusions; spike proteins are synthesized and maintained in precursor intermediate folding states and proteolysis permits the refolding and energy release required to create stable virus-cell linkages and membrane coalescence.

Gene Wiki entry for TMPRSS11D Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMPRSS11D Gene

Genomics for TMPRSS11D Gene

Regulatory Elements for TMPRSS11D Gene

Enhancers for TMPRSS11D Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04F067698 1.1 ENCODE 9.7 +183.5 183479 4.1 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A YBX1 DMAP1 YY1 UBA6 UBA6-AS1 CENPC STAP1 TMPRSS11D GC04P067653
GH04F067725 1 Ensembl ENCODE 9.8 +157.5 157482 4.4 PKNOX1 CBX3 JUN NFXL1 KAT2B ZNF316 CBX5 NFE2 TRIM24 MAFK UBA6 GNRHR TMPRSS11D LOC100419046 GC04P067742
GH04F068151 0.7 ENCODE 10.1 -268.5 -268473 1.3 SAP130 HLF ZMYM3 ZEB2 CEBPG JUND ATF3 SMARCA4 CEBPA CREB1 GCOM2 TMPRSS11GP TMPRSS11F TMPRSS11BNL TMPRSS11D FTLP10
GH04F067928 0.6 ENCODE 10.8 -44.7 -44739 0.1 ZNF217 GATA3 CTBP1 RCOR1 CUX1 DPF2 TMPRSS11D TMPRSS11A
GH04F067861 0.5 ENCODE 11.7 +22.3 22312 1.0 MTA2 IKZF1 JUNB EBF1 TMPRSS11D GNRHR LOC102724780
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMPRSS11D on UCSC Golden Path with GeneCards custom track

Genomic Location for TMPRSS11D Gene

Chromosome:
4
Start:
67,820,876 bp from pter
End:
67,884,032 bp from pter
Size:
63,157 bases
Orientation:
Minus strand

Genomic View for TMPRSS11D Gene

Genes around TMPRSS11D on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMPRSS11D Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMPRSS11D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMPRSS11D Gene

Proteins for TMPRSS11D Gene

  • Protein details for TMPRSS11D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60235-TM11D_HUMAN
    Recommended name:
    Transmembrane protease serine 11D
    Protein Accession:
    O60235
    Secondary Accessions:
    • Q08AF6

    Protein attributes for TMPRSS11D Gene

    Size:
    418 amino acids
    Molecular mass:
    46263 Da
    Quaternary structure:
    • Monomer.

neXtProt entry for TMPRSS11D Gene

Selected DME Specific Peptides for TMPRSS11D Gene

O60235:
  • DACQGDSGG
  • GDSGGPL
  • DIALVRL
  • CQGDSGGP
  • WILTAAHC
  • LTAAHCF
  • WPWQVSL

Post-translational modifications for TMPRSS11D Gene

Other Protein References for TMPRSS11D Gene

Antibody Products

  • R&D Systems Antibodies for TMPRSS11D (Airway Trypsin-like Protease/HAT)

Domains & Families for TMPRSS11D Gene

Gene Families for TMPRSS11D Gene

Suggested Antigen Peptide Sequences for TMPRSS11D Gene

Graphical View of Domain Structure for InterPro Entry

O60235

UniProtKB/Swiss-Prot:

TM11D_HUMAN :
  • Contains 1 peptidase S1 domain.
  • Belongs to the peptidase S1 family.
Domain:
  • Contains 1 peptidase S1 domain.
  • Contains 1 SEA domain.
Family:
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with TMPRSS11D: view

Function for TMPRSS11D Gene

Molecular function for TMPRSS11D Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Preferentially cleaves the C-terminal side of arginine residues at the P1 position of certain peptides, cleaving Boc-Phe-Ser-Arg-4-methylcoumaryl-7-amide most efficiently and having an optimum pH of 8.6 with this substrate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Strongly inhibited by diisopropyl fluorophosphate, leupeptin, antipain, aprotinin, and soybean trypsin inhibitor, but hardly inhibited by secretory leukocyte protease inhibitor at 10 microM.
UniProtKB/Swiss-Prot Function:
May play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions. Plays a role in the proteolytic processing of ACE2. Proteolytically cleaves and activates the human coronavirus 229E (HCoV-229E) spike glycoprotein which facilitate virus-cell membrane fusions; spike proteins are synthesized and maintained in precursor intermediate folding states and proteolysis permits the refolding and energy release required to create stable virus-cell linkages and membrane coalescence.

Enzyme Numbers (IUBMB) for TMPRSS11D Gene

Gene Ontology (GO) - Molecular Function for TMPRSS11D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004252 serine-type endopeptidase activity IEA --
GO:0008233 peptidase activity IEA,TAS 9565616
GO:0008236 serine-type peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with TMPRSS11D: view
genes like me logo Genes that share phenotypes with TMPRSS11D: view

Animal Model Products

miRNA for TMPRSS11D Gene

miRTarBase miRNAs that target TMPRSS11D

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMPRSS11D Gene

Localization for TMPRSS11D Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMPRSS11D Gene

Cell membrane; Single-pass type II membrane protein. Note=Activated by cleavage and secreted.
Transmembrane protease serine 11D catalytic chain: Secreted. Note=Activated by cleavage and secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMPRSS11D gene
Compartment Confidence
plasma membrane 5
extracellular 5
nucleus 2
golgi apparatus 2
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for TMPRSS11D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS 9565616
GO:0005886 plasma membrane IEA --
GO:0005887 integral component of plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMPRSS11D: view

Pathways & Interactions for TMPRSS11D Gene

SuperPathways for TMPRSS11D Gene

No Data Available

Interacting Proteins for TMPRSS11D Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000283916%0d%0a9606.ENSP00000414287%0d%0a9606.ENSP00000225728%0d%0a
Selected Interacting proteins: O60235-TM11D_HUMAN ENSP00000283916 for TMPRSS11D Gene via IID STRING MINT

Gene Ontology (GO) - Biological Process for TMPRSS11D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IDA 24227843
GO:0007585 respiratory gaseous exchange TAS 9565616
genes like me logo Genes that share ontologies with TMPRSS11D: view

No data available for Pathways by source and SIGNOR curated interactions for TMPRSS11D Gene

Drugs & Compounds for TMPRSS11D Gene

(5) Drugs for TMPRSS11D Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(4) Additional Compounds for TMPRSS11D Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TMPRSS11D: view

Transcripts for TMPRSS11D Gene

Unigene Clusters for TMPRSS11D Gene

Transmembrane protease, serine 11D:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMPRSS11D Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b
SP1: - -
SP2:
SP3: - - - - -
SP4:

Relevant External Links for TMPRSS11D Gene

GeneLoc Exon Structure for
TMPRSS11D
ECgene alternative splicing isoforms for
TMPRSS11D

Expression for TMPRSS11D Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TMPRSS11D Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMPRSS11D Gene

This gene is overexpressed in Esophagus - Mucosa (x17.9), Vagina (x16.7), Cervix - Ectocervix (x12.3), and Minor Salivary Gland (x5.7).

Protein differential expression in normal tissues from HIPED for TMPRSS11D Gene

This gene is overexpressed in Nasal epithelium (35.7) and Cervix (23.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TMPRSS11D Gene



Protein tissue co-expression partners for TMPRSS11D Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TMPRSS11D Gene:

TMPRSS11D

SOURCE GeneReport for Unigene cluster for TMPRSS11D Gene:

Hs.132195

mRNA Expression by UniProt/SwissProt for TMPRSS11D Gene:

O60235-TM11D_HUMAN
Tissue specificity: Located in the cells of the submucosal serous glands of the bronchi and trachea.
genes like me logo Genes that share expression patterns with TMPRSS11D: view

Primer Products

Orthologs for TMPRSS11D Gene

This gene was present in the common ancestor of animals.

Orthologs for TMPRSS11D Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMPRSS11D 34 35
  • 99.44 (n)
dog
(Canis familiaris)
Mammalia TMPRSS11D 34 35
  • 85.02 (n)
cow
(Bos Taurus)
Mammalia TMPRSS11D 34 35
  • 81.37 (n)
rat
(Rattus norvegicus)
Mammalia Tmprss11d 34
  • 75.94 (n)
mouse
(Mus musculus)
Mammalia Tmprss11d 34 16 35
  • 75.86 (n)
oppossum
(Monodelphis domestica)
Mammalia TMPRSS11D 35
  • 58 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMPRSS11D 35
  • 53 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 35
  • 52 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 48 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012842 34
  • 47.17 (n)
Species where no ortholog for TMPRSS11D was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TMPRSS11D Gene

ENSEMBL:
Gene Tree for TMPRSS11D (if available)
TreeFam:
Gene Tree for TMPRSS11D (if available)

Paralogs for TMPRSS11D Gene

genes like me logo Genes that share paralogs with TMPRSS11D: view

Variants for TMPRSS11D Gene

Sequence variations from dbSNP and Humsavar for TMPRSS11D Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs10004555 -- 67,867,295(+) taaaa(C/T)tggac intron-variant
rs10013693 -- 67,867,010(+) aaaag(A/G)gccaa intron-variant
rs10015325 -- 67,866,153(+) catgg(C/T)caact intron-variant
rs10020722 -- 67,873,247(+) CAGCA(A/T)TTTGA intron-variant
rs10022223 -- 67,841,145(+) agatg(A/G)ctgca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMPRSS11D Gene

Variant ID Type Subtype PubMed ID
esv3600854 CNV loss 21293372
esv3600855 CNV loss 21293372
nsv1007376 CNV gain 25217958
nsv829960 CNV loss 17160897

Variation tolerance for TMPRSS11D Gene

Residual Variation Intolerance Score: 22.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.01; 20.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMPRSS11D Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMPRSS11D

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMPRSS11D Gene

Disorders for TMPRSS11D Gene

MalaCards: The human disease database

(2) MalaCards diseases for TMPRSS11D Gene - From: DISEASES

Disorder Aliases PubMed IDs
brain stem cancer
  • malignant neoplasm of brain stem
brain stem glioma
  • brainstem neuroglial tumor
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TMPRSS11D

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMPRSS11D
genes like me logo Genes that share disorders with TMPRSS11D: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TMPRSS11D Gene

Publications for TMPRSS11D Gene

  1. Cloning and characterization of the cDNA for human airway trypsin- like protease. (PMID: 9565616) Yamaoka K. … Yasuoka S. (J. Biol. Chem. 1998) 2 3 4 64
  2. Purification, characterization, and localization of a novel trypsin- like protease found in the human airway. (PMID: 9070615) Yasuoka S. … Sano T. (Am. J. Respir. Cell Mol. Biol. 1997) 2 3 4 64
  3. TMPRSS2 and ADAM17 Cleave ACE2 Differentially and Only Proteolysis by TMPRSS2 Augments Entry Driven by the Severe Acute Respiratory Syndrome Coronavirus Spike Protein. (PMID: 24227843) Heurich A. … PAPhlmann S. (J. Virol. 2014) 3 4 64
  4. Human airway trypsin-like protease stimulates human bronchial fibroblast proliferation in a protease-activated receptor-2-dependent pathway. (PMID: 16199437) Matsushima R. … Yasuoka S. (Am. J. Physiol. Lung Cell Mol. Physiol. 2006) 3 22 64
  5. Proteolytic activation of influenza viruses by serine proteases TMPRSS2 and HAT from human airway epithelium. (PMID: 16973594) BAPttcher E. … Matrosovich M. (J. Virol. 2006) 3 22 64

Products for TMPRSS11D Gene

Sources for TMPRSS11D Gene

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