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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TMPRSS11D Gene

protein-coding   GIFtS: 52
GCID: GC04M068686

Transmembrane Protease, Serine 11D

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Transmembrane Protease, Serine 11D1 2     Transmembrane Protease Serine 11D2
Airway Trypsin Like Protease1 2     EC 3.4.21.-3
Airway Trypsin-Like Protease2 3     EC 3.4.218
HAT2 3     

External Ids:    HGNC: 240591   Entrez Gene: 94072   Ensembl: ENSG000001538027   OMIM: 6053695   UniProtKB: O602353   

Export aliases for TMPRSS11D gene to outside databases

Previous GC identifers: GC04M068518 GC04M068369 GC04M064599


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TMPRSS11D Gene:
This gene encodes a trypsin-like serine protease released from the submucosal serous glands onto mucous membrane.
It is a type II integral membrane protein and has 29-38% identity in the sequence of the catalytic region with
human hepsin, enteropeptidase, acrosin, and mast cell tryptase. The noncatalytic region has little similarity to
other known proteins. This protein may play some biological role in the host defense system on the mucous
membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions.
(provided by RefSeq, Jul 2008)

GeneCards Summary for TMPRSS11D Gene: 
TMPRSS11D (transmembrane protease, serine 11D) is a protein-coding gene. Diseases associated with TMPRSS11D include brain stem glioma, and bronchitis. GO annotations related to this gene include peptidase activity and serine-type endopeptidase activity. An important paralog of this gene is TMPRSS3.

UniProtKB/Swiss-Prot: TM11D_HUMAN, O60235
Function: May play some biological role in the host defense system on the mucous membrane independently of or in
cooperation with other substances in airway mucous or bronchial secretions

Gene Wiki entry for TMPRSS11D Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NT_022778.16  NC_018915.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TMPRSS11D gene promoter:
         Bach1   CREB   p53   deltaCREB   FOXO4   Sox9   CUTL1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMPRSS11D promoter sequence
   Search SABiosciences Chromatin IP Primers for TMPRSS11D

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMPRSS11D


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q13.2   Ensembl cytogenetic band:  4q13.2   HGNC cytogenetic band: 4q13.2

TMPRSS11D Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMPRSS11D gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M068686:  view genomic region     (about GC identifiers)

Start:
68,686,594 bp from pter      End:
68,749,750 bp from pter
Size:
63,157 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TM11D_HUMAN, O60235 (See protein sequence)
Recommended Name: Transmembrane protease serine 11D precursor  
Size: 418 amino acids; 46263 Da
Subunit: Monomer
Subcellular location: Cell membrane; Single-pass type II membrane protein. Note=Activated by cleavage and secreted
Subcellular location: Transmembrane protease serine 11D catalytic chain: Secreted. Note=Activated by cleavage and
secreted
Secondary accessions: Q08AF6

Explore the universe of human proteins at neXtProt for TMPRSS11D: NX_O60235

Explore proteomics data for TMPRSS11D at MOPED 

4/7 DME Specific Peptides for TMPRSS11D (O60235) (see all 7)
 DIALVRL  GDSGGPL  WPWQVSL  LTAAHCF 

TMPRSS11D Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

TMPRSS11D Protein Expression
REFSEQ proteins: NP_004253.1  
ENSEMBL proteins: 
 ENSP00000283916   ENSP00000421381   ENSP00000442045  

Human Recombinant Protein Products for TMPRSS11D: 
Browse Purified and Recombinant Proteins at EMD Millipore
R&D Systems Recombinant & Natural Proteins for TMPRSS11D (Airway Trypsin-like Protease/HAT)
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OriGene Protein Over-expression Lysate for TMPRSS11D
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Novus Biologicals TMPRSS11D Protein
Novus Biologicals TMPRSS11D Lysates
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates 
Browse ProSpec Recombinant Proteins
Cloud-Clone Corp. Proteins for TMPRSS11D 

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region IEA--
GO:0005887integral to plasma membrane IEA--
GO:0016021integral to membrane ----

TMPRSS11D for ontologies           About GeneDecksing



TMPRSS11D Antibody Products: 
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Cloud-Clone Corp. CLIAs for TMPRSS11D


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
TMPRSS: Serine peptidases / Transmembrane

5/6 InterPro protein domains (see all 6):
 IPR001314 Peptidase_S1A
 IPR000082 SEA_dom
 IPR017329 Pept_S1A_HAT/DESC1
 IPR009003 Trypsin-like_Pept_dom
 IPR001254 Peptidase_S1

Graphical View of Domain Structure for InterPro Entry O60235

ProtoNet protein and cluster: O60235

3 Blocks protein domains:
IPB000082 SEA domain
IPB001254 Serine protease
IPB001314 Chymotrypsin serine protease family (S1) signature


UniProtKB/Swiss-Prot: TM11D_HUMAN, O60235
Similarity: Belongs to the peptidase S1 family
Similarity: Contains 1 peptidase S1 domain
Similarity: Contains 1 SEA domain


TMPRSS11D for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: TM11D_HUMAN, O60235
Function: May play some biological role in the host defense system on the mucous membrane independently of or in
cooperation with other substances in airway mucous or bronchial secretions
Catalytic activity: Preferentially cleaves the C-terminal side of arginine residues at the P1 position of certain
peptides, cleaving Boc-Phe-Ser-Arg-4-methylcoumaryl-7-amide most efficiently and having an optimum pH of 8.6 with
this substrate
Enzyme regulation: Strongly inhibited by diisopropyl fluorophosphate, leupeptin, antipain, aprotinin, and soybean
trypsin inhibitor, but hardly inhibited by secretory leukocyte protease inhibitor at 10 microM

     Enzyme Numbers (IUBMB): EC 3.4.212 EC 3.4.21.-1

     Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003824catalytic activity ----
GO:0004252serine-type endopeptidase activity IEA--
GO:0008233peptidase activity TAS9565616
     
TMPRSS11D for ontologies           About GeneDecksing


Phenotypes:
     1 MGI mutant phenotype (inferred from 1 allele(MGI details for Tmprss11d):
 tumorigenesis 

TMPRSS11D for phenotypes           About GeneDecksing

Animal Models:
   inGenious Targeting Laboratory - Custom generated mouse model solutions for TMPRSS11D 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TMPRSS11D

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TMPRSS11D 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TMPRSS11D 

miRNA
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QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TMPRSS11D
2 QIAGEN miScript miRNA Assays for microRNAs that regulate TMPRSS11D:
hsa-miR-3117-3p hsa-miR-1305
SwitchGear 3'UTR luciferase reporter plasmidTMPRSS11D 3' UTR sequence
Inhib. RNA
Products:
    
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Gene Editing
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Clone
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GenScript: all cDNA clones in your preferred vector: TMPRSS11D (NM_004262)
Sino Biological Human cDNA Clone for TMPRSS11D
DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMPRSS11D
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMPRSS11D
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                     Customized lentivirus expression plasmids for stable overexpression of TMPRSS11D 

Cell Line
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Search LifeMap BioReagents cell lines for TMPRSS11D
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMPRSS11D


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section




Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TMPRSS11D

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

2 Interacting proteins for TMPRSS11D (O602352 ENSP000002839164) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
MST1P269272MINT-8302112
--ENSP000003082264STRING: ENSP00000308226
About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006508proteolysis IEA--
GO:0007585respiratory gaseous exchange TAS9565616

TMPRSS11D for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

TMPRSS11D for compounds           About GeneDecksing

EMD Millipore small molecules for TMPRSS11D:
Small Molecule - inhibitor
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TMPRSS11D (TM11D)

9 Novoseek inferred chemical compound relationships for TMPRSS11D gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
hatpa 92.1 7 8908500 (2), 9747464 (1)
mitozolomide 87.5 5 10022554 (3), 8908500 (1), 9747464 (1)
o6-benzylguanine 69.5 9 8908500 (3), 9366274 (3), 9747464 (1)
leupeptin 64.1 3 14500256 (1), 8741534 (1), 16199437 (1)
serine 35.8 9 16973594 (2), 17237151 (2), 14500256 (1), 15102084 (1) (see all 7)
aprotinin 33.8 2 14500256 (1), 8741534 (1)
fibrinogen 4.65 17 9864967 (6), 9071156 (5)
calcium 0 3 12630574 (2), 16199437 (1)
arginine 0 3 8741534 (1), 17237151 (1)

Search CenterWatch for drugs/clinical trials and news about TMPRSS11D / TM11D

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TMPRSS11D gene: 
NM_004262.2  

Unigene Cluster for TMPRSS11D:

Transmembrane protease, serine 11D
Hs.132195  [show with all ESTs]
Unigene Representative Sequence: NM_004262
9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000283916(uc003hdq.3 uc011caj.2) ENST00000505533(uc003hdp.3)
ENST00000514868 ENST00000502573 ENST00000509584 ENST00000508409 ENST00000502822
ENST00000511931 ENST00000545541
miRNA
Products:
     
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TMPRSS11D
2 QIAGEN miScript miRNA Assays for microRNAs that regulate TMPRSS11D:
hsa-miR-3117-3p hsa-miR-1305
SwitchGear 3'UTR luciferase reporter plasmidTMPRSS11D 3' UTR sequence
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
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Clone
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OriGene ORF clones in mouse, rat for TMPRSS11D
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: TMPRSS11D (NM_004262)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMPRSS11D
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMPRSS11D
Sirion Biotech Customized lentivirus for stable overexpression of TMPRSS11D 
                     Customized lentivirus expression plasmids for stable overexpression of TMPRSS11D 
Primer
Products:
    
OriGene qPCR primer pairs and template standards for TMPRSS11D
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  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMPRSS11D
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMPRSS11D

Additional mRNA sequence: 

AB002134.1 AK094054.1 AK290289.1 AK296853.1 BC033295.1 BC125195.1 BC125196.1 

3 DOTS entries:

DT.92062848  DT.91653726  DT.92062847 

22 AceView cDNA sequences:

BM955804 AK094054 AB002134 NM_004262 AL603214 BC033295 AW084009 BG679995 
BX649007 BF353289 BM955803 BE149575 BU686010 CD618233 CD618236 CD692735 
CD618234 AL712568 CD618239 CD689942 BF354105 BF353317 

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for TMPRSS11D    About this scheme

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b
SP1:                                      -           -                                       
SP2:                                                                                          
SP3:              -           -           -     -     -                                       
SP4:                                                                                          


ECgene alternative splicing isoforms for TMPRSS11D

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TMPRSS11D expression in normal human tissues (normalized intensities)      TMPRSS11D embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
TMPRSS11D Expression
About this image


TMPRSS11D expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/7 selected tissues (see all 7) fully expand
 
 Nose (Sensory Organs)    fully expand to see all 2 entries
         sensory organ/nose/naris   
 
 Lung (Respiratory System)
         Human Pulmonary Microvascular Endothelial Cells (HPMEC)   
 
 Gut Tube (Gastrointestinal Tract)
         Foregut
 
 Endothelium (Respiratory System)
         Human Pulmonary Microvascular Endothelial Cells (HPMEC)   
 
 Eye (Sensory Organs)
         Human Corneal Epithelial Cells (HCEpiC)   

See TMPRSS11D Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TMPRSS11D

SOURCE GeneReport for Unigene cluster: Hs.132195

UniProtKB/Swiss-Prot: TM11D_HUMAN, O60235
Tissue specificity: Located in the cells of the submucosal serous glands of the bronchi and trachea

    SABiosciences Custom PCR Arrays for TMPRSS11D
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QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMPRSS11D
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMPRSS11D
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMPRSS11D

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for TMPRSS11D gene from 4/10 species (see all 10)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Tmprss11d1 , 5 transmembrane protease, serine 11d1, 5 75.86(n)1
66.67(a)1
  5 (43.56 cM)5
2313821  NM_145561.21  NP_663536.11 
 863022175 
lizard
(Anolis carolinensis)
Reptilia --
Uncharacterized protein
12(a)
possible ortholog
GL343765.1(146281-196748)
zebrafish
(Danio rerio)
Actinopterygii CK000011.12   -- 74.03(n)    CK000011.1 
mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP0089941 AGAP008994-PA 45.22(n)
40.43(a)
  1279956  XM_319744.4  XP_319744.4 


ENSEMBL Gene Tree for TMPRSS11D (if available)
TreeFam Gene Tree for TMPRSS11D (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for TMPRSS11D gene
TMPRSS32  TMPRSS11B2  TMPRSS62  TMPRSS11A2  TMPRSS72  TMPRSS52  TMPRSS42  ST142  
TMPRSS132  TMPRSS11E2  KLKB12  TMPRSS22  F112  HPN2  TMPRSS152  TMPRSS11F2  
18/101 SIMAP similar genes for TMPRSS11D using alignment to 3 protein entries:     TM11D_HUMAN (see all proteins) (see all similar genes):
HAT    PRSS1    TMPRSS11A    TMPRSS11B    DESC1    TMPRSS11E
TMPRSS11F    DKFZp586F0824    TMPRSS4    F12    PLAU    F9
CFI    CTRB1    PRSS41    PRSS45    ST14    TMPRSS13

TMPRSS11D for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/1232 SNPs in TMPRSS11D are shown (see all 1232)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 4 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs738296191,2
C--68686165(+) TATCTT/GTTCAC 1 -- ds50013Minor allele frequency- G:0.09WA NA 240
rs1808768491,2
--68686318(+) CAGCTA/GCACAC 1 -- ds50010--------
rs1845197391,2
--68686377(+) TTACCC/TTAAAT 1 -- ds50010--------
rs1897772261,2
--68686414(+) GTGCAA/TCTGAG 1 -- ds50010--------
rs65521231,2
C,F,H--68686507(+) GGGGCG/AGTTCT 1 -- ds500122Minor allele frequency- A:0.26NA NS EA WA CSA 2354
rs2010223911,2
C--68686556(+) TCCTTA/CAAAAG 1 -- ds50010--------
rs170886551,2
C,F,H--68686657(+) GCCAAG/TAGTTG 1 -- ut319Minor allele frequency- T:0.04NA NS 926
rs1387208751,2
--68686668(+) GTTGCA/GTTTTC 1 -- ut310--------
rs802721601,2
F--68686732(+) ACATCA/GGGAAA 1 -- ut310--------
rs623012601,2
C,F--68686942(+) TTTACA/GTTATA 1 -- ut312Minor allele frequency- G:0.04NA 122

HapMap Linkage Disequilibrium report for TMPRSS11D (68686594 - 68749750 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for TMPRSS11D:    About this table     
Variant IDTypeSubtypePubMed ID
nsv879219CNV Loss21882294
nsv829960CNV Loss17160897
nsv879214CNV Gain21882294

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 605369    OMIM disorders: --

8 diseases for TMPRSS11D:    About MalaCards
brain stem glioma    bronchitis    endometrial adenocarcinoma    dwarfism
malaria    influenza    psoriasis    adenocarcinoma

1 disease from the University of Copenhagen DISEASES database for TMPRSS11D:
Brain stem glioma

TMPRSS11D for disorders           About GeneDecksing

2 Novoseek inferred disease relationships for TMPRSS11D gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
airways disease 61.5 6 14500256 (2), 11326745 (1), 9071156 (1), 8741534 (1) (see all 5)
bronchitis chronic 31.5 1 8741534 (1)


Export disorders for TMPRSS11D gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for TMPRSS11D gene, integrated from 9 sources (see all 65):
(articles sorted by number of sources associating them with TMPRSS11D)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Cloning and characterization of the cDNA for human airway trypsin- like protease. (PubMed id 9565616)1, 2, 3 Yamaoka K.... Yasuoka S. (1998)
  2. Purification, characterization, and localization of a novel trypsin-like protease found in the human airway. (PubMed id 9070615)1, 2, 3 Yasuoka S....Sano T. (1997)
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  4. Human airway trypsin-like protease stimulates human bronchial fibroblast proliferation in a protease-activated receptor-2-dependent pathway. (PubMed id 16199437)1, 9 Matsushima R....Yasuoka S. (2006)
  5. Human airway trypsin-like protease induces PAR-2-mediated IL-8 release in psoriasis vulgaris. (PubMed id 15102084)1, 9 Iwakiri K....Kawanami O. (2004)
  6. Effect of human airway trypsin-like protease on intracellular free Ca2+ concentration in human bronchial epithelial cells. (PubMed id 12630574)1, 9 Miki M....Sone S. (2003)
  7. Human airway trypsin-like protease induces amphiregulin release through a mechanism involving protease-activated receptor-2-mediated ERK activation and TNF alpha-converting enzyme activity in airway epithelial cells. (PubMed id 16336275)1, 9 Chokki M....Kamimura T. (2005)
  8. Localization of human airway trypsin-like protease in the airway: an immunohistochemical study. (PubMed id 11326745)1, 9 Takahashi M....Yasuoka S. (2001)
  9. Proteolytic activation of influenza viruses by serine proteases TMPRSS2 and HAT from human airway epithelium. (PubMed id 16973594)1, 9 Bottcher E....Matrosovich M. (2006)
  10. Matriptase, HAT, and TMPRSS2 activate the hemagglutini n of H9N2 influenza A viruses. (PubMed id 23192872)1 Baron J....Bottcher-Friebertshauser E. (2013)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Disorders
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  Query String
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 9407 HGNC: 24059 AceView: HAT Ensembl:ENSG00000153802 euGenes: HUgn9407
ECgene: TMPRSS11D H-InvDB: TMPRSS11D

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for TMPRSS11D Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for TMPRSS11D gene:
Search GeneIP for patents involving TMPRSS11D

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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