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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TMPRSS11B Gene

protein-coding   GIFtS: 46
GCID: GC04M069092

Transmembrane Protease, Serine 11B

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Transmembrane Protease, Serine 11B1 2
Airway Trypsin-Like Protease 52 3
Transmembrane Protease Serine 11B2
EC 3.4.21.-3
HATL53

External Ids:    HGNC: 253981   Entrez Gene: 1327242   Ensembl: ENSG000001858737   UniProtKB: Q86T263   

Export aliases for TMPRSS11B gene to outside databases

Previous GC identifers: GC04M068923 GC04M068774 GC04M065004


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TMPRSS11B Gene: 
TMPRSS11B (transmembrane protease, serine 11B) is a protein-coding gene. Diseases associated with TMPRSS11B include myocardial infarction. GO annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is TMPRSS7.

UniProtKB/Swiss-Prot: TM11B_HUMAN, Q86T26
Function: Probable serine protease (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.2  NT_022778.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TMPRSS11B gene promoter:
         S8   LHX3b/Lhx3b   Pbx1a   HTF   LHX3a/Lhx3a   FOXD3   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMPRSS11B promoter sequence
   Search SABiosciences Chromatin IP Primers for TMPRSS11B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMPRSS11B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q13.2   Ensembl cytogenetic band:  4q13.2   HGNC cytogenetic band: 4q13.2

TMPRSS11B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMPRSS11B gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M069092:  view genomic region     (about GC identifiers)

Start:
69,092,371 bp from pter      End:
69,111,438 bp from pter
Size:
19,068 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TM11B_HUMAN, Q86T26 (See protein sequence)
Recommended Name: Transmembrane protease serine 11B  
Size: 416 amino acids; 46337 Da
Subcellular location: Membrane; Single-pass type II membrane protein (Potential)
Secondary accessions: A8K4D9

Explore the universe of human proteins at neXtProt for TMPRSS11B: NX_Q86T26

Explore proteomics data for TMPRSS11B at MOPED 

TMPRSS11B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

TMPRSS11B Protein Expression

REFSEQ proteins: NP_872308.2  
ENSEMBL proteins: 
 ENSP00000330475  

Human Recombinant Protein Products for TMPRSS11B: 
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Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region IEA--
GO:0005887integral to plasma membrane IEA--

TMPRSS11B for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
TMPRSS: Serine peptidases / Transmembrane

5/6 InterPro protein domains (see all 6):
 IPR001314 Peptidase_S1A
 IPR000082 SEA_dom
 IPR017329 Pept_S1A_HAT/DESC1
 IPR009003 Trypsin-like_Pept_dom
 IPR001254 Peptidase_S1

Graphical View of Domain Structure for InterPro Entry Q86T26

ProtoNet protein and cluster: Q86T26

3 Blocks protein domains:
IPB000082 SEA domain
IPB001254 Serine protease
IPB001314 Chymotrypsin serine protease family (S1) signature


UniProtKB/Swiss-Prot: TM11B_HUMAN, Q86T26
Similarity: Belongs to the peptidase S1 family
Similarity: Contains 1 peptidase S1 domain
Similarity: Contains 1 SEA domain


TMPRSS11B for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: TM11B_HUMAN, Q86T26
Function: Probable serine protease (By similarity)

     Enzyme Number (IUBMB): EC 3.4.21.-1

     Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003824catalytic activity ----
GO:0004252serine-type endopeptidase activity IEA--
     
TMPRSS11B for ontologies           About GeneDecksing


Animal Models:
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section




Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMPRSS11B

Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006508proteolysis IEA--

TMPRSS11B for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
EMD Millipore small molecules for TMPRSS11B:
Small Molecule - inhibitor
Browse drugs & compounds from Enzo Life Sciences

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Search CenterWatch for drugs/clinical trials and news about TMPRSS11B / TM11B

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TMPRSS11B gene: 
NM_182502.3  

Unigene Cluster for TMPRSS11B:

Transmembrane protease, serine 11B
Hs.407122  [show with all ESTs]
Unigene Representative Sequence: BX537945
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000332644(uc003hdw.4) ENST00000510856 ENST00000502365
miRNA
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hsa-miR-520d-5p hsa-miR-524-5p
SwitchGear 3'UTR luciferase reporter plasmidTMPRSS11B 3' UTR sequence
Inhib. RNA
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Additional mRNA sequence: 

AK290904.1 AK310210.1 AL833167.1 BC126195.1 BX537945.1 

3 DOTS entries:

DT.75151838  DT.92023309  DT.75159756 

9 AceView cDNA sequences:

AW117848 AL833167 BF188818 BX537945 NM_182502 AL701892 BF354411 AW263856 
AW238624 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TMPRSS11B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CAATCTTGCA
TMPRSS11B Expression
About this image


See TMPRSS11B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TMPRSS11B

SOURCE GeneReport for Unigene cluster: Hs.407122
    SABiosciences Custom PCR Arrays for TMPRSS11B
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SABiosciences RT2 qPCR Primer Assay in human, mouse / rat TMPRSS11B
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QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMPRSS11B
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMPRSS11B

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for TMPRSS11B gene from 3/8 species (see all 8)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Tmprss11c5 transmembrane protease, serine 11c   --   5 (43.56 cM) 86231481 
chicken
(Gallus gallus)
Aves TMPRSS11B6
transmembrane protease, serine 11B
52(a)
1 ↔ 1
4(51069659-51076359)
lizard
(Anolis carolinensis)
Reptilia TMPRSS11B6
--
Uncharacterized protein
49(a)
11(a)
1 ↔ 1
possible ortholog
6(58297105-58304622)
GL343765.1(146281-196748)


ENSEMBL Gene Tree for TMPRSS11B (if available)
TreeFam Gene Tree for TMPRSS11B (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for TMPRSS11B gene
TMPRSS72  TMPRSS52  TMPRSS42  ST142  TMPRSS11D2  TMPRSS132  TMPRSS11E2  TMPRSS32  
TMPRSS22  KLKB12  F112  HPN2  TMPRSS152  TMPRSS62  TMPRSS11A2  TMPRSS11F2  
18/76 SIMAP similar genes for TMPRSS11B using alignment to 1 protein entry:     TM11B_HUMAN(see all similar genes):
PRSS1    F2    TMPRSS11D    TMPRSS11F    HAT    TMPRSS11A
PRSS22    HP    PROC1    DKFZp586F0824    PROC    PRSS8
TMPRSS2    DESC1    F12    CORIN    CTRB1    CTRB2

TMPRSS11B for paralogs           About GeneDecksing


1 Pseudogenes.org Pseudogene for TMPRSS11B
PGOHUM00000245558


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/506 SNPs in TMPRSS11B are shown (see all 506)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 4 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1484144341,2
--69091909(+) CTCTCC/TCTGGA 1 -- ds50010--------
rs43172671,2
C,H--69091918(+) GATCTT/CATACT 1 -- ds500117Minor allele frequency- C:0.00NS EA NA WA CSA 791
rs1153984241,2
F--69092001(+) ATGGCT/CACCCC 1 -- ds50011Minor allele frequency- C:0.08WA 118
rs1836439431,2
--69092012(+) CTCAGA/GGATGT 1 -- ds50010--------
rs350626491,2
C,F--69092040(+) CTAAAG/TTATAG 1 -- ds500110Minor allele frequency- T:0.43NA WA CSA 253
rs1146440231,2
F--69092089(+) TTTCCT/CTTATA 1 -- ds50011Minor allele frequency- C:0.08WA 118
rs1439906391,2
--69092101(+) CATTTA/TTCGTA 1 -- ds50010--------
rs1465039101,2
C--69092141(+) TGCCTA/GTCTTT 1 -- ds50010--------
rs1890821851,2
--69092184(+) ATTGTA/GTCTAT 1 -- ds50010--------
rs1931387761,2
--69092191(+) CTATAC/TCTGAC 1 -- ds50010--------

HapMap Linkage Disequilibrium report for TMPRSS11B (69092371 - 69111438 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for TMPRSS11B:    About this table     
Variant IDTypeSubtypePubMed ID
nsv520487CNV Loss19592680

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
2 diseases for TMPRSS11B:    About MalaCards
myocardial infarction    


TMPRSS11B for disorders           About GeneDecksing

Genetic Association Database (GAD): TMPRSS11B
Human Genome Epidemiology (HuGE) Navigator: TMPRSS11B (2 documents)

Export disorders for TMPRSS11B gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for TMPRSS11B gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with TMPRSS11B)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Gene variants associated with ischemic stroke: the cardiovascular health study. (PubMed id 19023099)1, 4 Luke M.M....Psaty B.M. (2009)
  2. Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study. (PubMed id 17975119)1, 4 Shiffman D....Psaty B.M. (2008)
  3. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
  4. The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (2006)
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
  6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
  7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
  8. From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336)1 Wiemann S....Poustka A. (2004)
  9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
  10. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1 Wiemann S.... Poustka A. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 132724 HGNC: 25398 AceView: DKFZp686L1818 Ensembl:ENSG00000185873 euGenes: HUgn132724
ECgene: TMPRSS11B H-InvDB: TMPRSS11B

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for TMPRSS11B Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for TMPRSS11B gene:
Search GeneIP for patents involving TMPRSS11B

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 Browse Purified and Recombinant Proteins at EMD Millipore
 EMD Millipore small molecules (inhibitor) for TMPRSS11B
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 Proteins for TMPRSS11B
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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(GIFtS: 73)
transforming growth factor, beta 1
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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