Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TMPRSS11B Gene

Aliases for TMPRSS11B Gene

  • Transmembrane Protease, Serine 11B 2 3
  • Airway Trypsin-Like Protease 5 4
  • EC 3.4.21.- 4
  • HATL5 4

External Ids for TMPRSS11B Gene

Summaries for TMPRSS11B Gene

GeneCards Summary for TMPRSS11B Gene

TMPRSS11B is a Protein Coding gene. GO annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is HPN.

UniProtKB/Swiss-Prot for TMPRSS11B Gene

  • Serine protease.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMPRSS11B Gene

Genomics for TMPRSS11B Gene

Genomic Location for TMPRSS11B Gene

68,226,653 bp from pter
68,245,720 bp from pter
19,068 bases
Minus strand

Genomic View for TMPRSS11B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMPRSS11B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMPRSS11B Gene

Regulatory Elements for TMPRSS11B Gene

Proteins for TMPRSS11B Gene

  • Protein details for TMPRSS11B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protease serine 11B
    Protein Accession:
    Secondary Accessions:
    • A8K4D9

    Protein attributes for TMPRSS11B Gene

    416 amino acids
    Molecular mass:
    46337 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMPRSS11B Gene

Proteomics data for TMPRSS11B Gene at MOPED

Post-translational modifications for TMPRSS11B Gene

  • Glycosylation at Asn72, Asn107, and Asn315

Other Protein References for TMPRSS11B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMPRSS11B Gene

Domains for TMPRSS11B Gene

Gene Families for TMPRSS11B Gene

  • TMPRSS :Serine peptidases / Transmembrane


  • Contains 1 peptidase S1 domain.:
    • Q86T26
  • Contains 1 SEA domain.:
    • Q86T26
  • Belongs to the peptidase S1 family.:
    • Q86T26
genes like me logo Genes that share domains with TMPRSS11B: view

Function for TMPRSS11B Gene

Molecular function for TMPRSS11B Gene

UniProtKB/Swiss-Prot EnzymeRegulation: Inhibited by aprotinin, leupeptin, benzamidine, SERPINA1, SPINT1 and SPINT2.
UniProtKB/Swiss-Prot Function: Serine protease.

Enzyme Numbers (IUBMB) for TMPRSS11B Gene

Gene Ontology (GO) - Molecular Function for TMPRSS11B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function --
GO:0003824 catalytic activity --
GO:0004252 serine-type endopeptidase activity IEA --
GO:0008236 serine-type peptidase activity IDA 24498351
genes like me logo Genes that share ontologies with TMPRSS11B: view

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TMPRSS11B Gene

Localization for TMPRSS11B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMPRSS11B Gene

Cell membrane; Single-pass type II membrane protein.

Subcellular locations from

Jensen Localization Image for TMPRSS11B Gene COMPARTMENTS Subcellular localization image for TMPRSS11B gene
Compartment Confidence
extracellular 2
golgi apparatus 2
plasma membrane 2
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for TMPRSS11B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region --
GO:0005886 plasma membrane IDA 24498351
GO:0005887 integral component of plasma membrane IEA --
GO:0070062 extracellular exosome IDA 19199708
genes like me logo Genes that share ontologies with TMPRSS11B: view

Pathways for TMPRSS11B Gene

SuperPathways for TMPRSS11B Gene

No Data Available

Interacting Proteins for TMPRSS11B Gene

Gene Ontology (GO) - Biological Process for TMPRSS11B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with TMPRSS11B: view

No data available for Pathways by source for TMPRSS11B Gene

Transcripts for TMPRSS11B Gene

mRNA/cDNA for TMPRSS11B Gene

(3) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMPRSS11B Gene

Transmembrane protease, serine 11B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMPRSS11B Gene

No ASD Table

Relevant External Links for TMPRSS11B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMPRSS11B Gene

mRNA expression in normal human tissues for TMPRSS11B Gene

mRNA differential expression in normal tissues according to GTEx for TMPRSS11B Gene

This gene is overexpressed in Esophagus - Mucosa (34.0), Vagina (9.2), Cervix - Ectocervix (4.8), and Minor Salivary Gland (4.6).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for TMPRSS11B Gene

SOURCE GeneReport for Unigene cluster for TMPRSS11B Gene Hs.407122

genes like me logo Genes that share expressions with TMPRSS11B: view

Orthologs for TMPRSS11B Gene

This gene was present in the common ancestor of animals.

Orthologs for TMPRSS11B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMPRSS11B 36
  • 99.36 (n)
  • 98.56 (a)
  • 99 (a)
(Bos Taurus)
Mammalia -- 37
  • 41 (a)
(Canis familiaris)
Mammalia TMPRSS11B 36
  • 84.15 (n)
  • 73.41 (a)
  • 51 (a)
(Mus musculus)
Mammalia Tmprss11bnl 37
  • 51 (a)
Tmprss11c 16
(Monodelphis domestica)
Mammalia TMPRSS11B 37
  • 53 (a)
(Ornithorhynchus anatinus)
Mammalia TMPRSS11B 37
  • 50 (a)
(Gallus gallus)
Aves -- 37
  • 38 (a)
(Anolis carolinensis)
Reptilia -- 37
  • 40 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004567 36
  • 47.77 (n)
  • 42.91 (a)
Species with no ortholog for TMPRSS11B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TMPRSS11B Gene

Gene Tree for TMPRSS11B (if available)
Gene Tree for TMPRSS11B (if available)

Paralogs for TMPRSS11B Gene Pseudogenes for TMPRSS11B Gene

genes like me logo Genes that share paralogs with TMPRSS11B: view

Variants for TMPRSS11B Gene

Sequence variations from dbSNP and Humsavar for TMPRSS11B Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs1320266 -- 68,238,226(+) AAAAA(C/T)TGATT intron-variant
rs2319794 -- 68,234,801(-) CTAGA(C/T)GTACT intron-variant
rs2319795 -- 68,229,211(-) ACTAT(C/T)TAATC intron-variant
rs2319796 - 68,228,857(-) AGAAG(A/C)CTTTT reference, missense
rs2319797 - 68,228,789(-) CTGAT(A/T)CAATG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for TMPRSS11B Gene

Variant ID Type Subtype PubMed ID
nsv520487 CNV Loss 19592680

Relevant External Links for TMPRSS11B Gene

HapMap Linkage Disequilibrium report

Disorders for TMPRSS11B Gene

Relevant External Links for TMPRSS11B

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with TMPRSS11B: view

No data available for UniProtKB/Swiss-Prot for TMPRSS11B Gene

Publications for TMPRSS11B Gene

  1. HATL5: a cell surface serine protease differentially expressed in epithelial cancers. (PMID: 24498351) Miller G.S. … List K. (PLoS ONE 2014) 3 4
  2. Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study. (PMID: 17975119) Shiffman D. … Psaty B.M. (Arterioscler. Thromb. Vasc. Biol. 2008) 3 49
  3. Gene variants associated with ischemic stroke: the cardiovascular health study. (PMID: 19023099) Luke M.M. … Psaty B.M. (Stroke 2009) 3 49
  4. Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). (PMID: 19199708) Gonzalez-Begne M. … Yates J.R. (J. Proteome Res. 2009) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4

Products for TMPRSS11B Gene

  • antibodies-online proteins for TMPRSS11B
  • antibodies-online antibodies for TMPRSS11B
  • antibodies-online kits for TMPRSS11B

Sources for TMPRSS11B Gene

Back to Top