TMPRSS11B Gene
protein-coding GIFtS: 40
GCID: GC04M069092
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|
transmembrane protease, serine 11B
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Aliases
for TMPRSS11B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Transmembrane Protease, Serine 11B1 2 | | Airway Trypsin-Like Protease 52 3 | | Transmembrane Protease Serine 11B2 | | EC 3.4.21.-3 | | HATL53 |
Export aliases for TMPRSS11B gene to outside databasesPrevious GC identifers: GC04M068923 GC04M068774 GC04M065004 |
Summaries
for TMPRSS11B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: TM11B_HUMAN, Q86T26Function: Probable serine protease (By similarity)
|
Genomic Views
for TMPRSS11B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000004.11 NC_018915.1 NT_022778.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TMPRSS11B gene promoter:
S8 LHX3b/Lhx3b Pbx1a HTF LHX3a/Lhx3a FOXD3 C/EBPalpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for TMPRSS11B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMPRSS11B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4q13.2 Ensembl cytogenetic band: 4q13.2 HGNC cytogenetic band: 4q13.2TMPRSS11B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04M069092: view genomic region
(about GC identifiers)
Start:
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69,092,371 bp from pter |
End:
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69,111,438 bp from pter |
Size:
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19,068 bases |
Orientation:
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minus strand |
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Proteins
for TMPRSS11B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TM11B_HUMAN, Q86T26 (See
protein sequence)Recommended Name: Transmembrane protease serine 11B Size: 416 amino acids; 46337 Da
Subcellular location: Membrane; Single-pass type II membrane protein (Potential)
Secondary accessions: A8K4D9Explore the universe of human proteins at neXtProt for TMPRSS11B: NX_Q86T26
TMPRSS11B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_872308.2
ENSEMBL proteins: ENSP00000330475
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- | | GO:0005887 | integral to plasma membrane |
IEA | -- |
TMPRSS11B for ontologies About GeneDecksing
TMPRSS11B Antibody Products:
Assay Products for TMPRSS11B: |
Protein
Domains /
Families
for TMPRSS11B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TMPRSS11B for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q86T26ProtoNet protein and cluster: Q86T26 3 Blocks protein families: IPB000082 SEA domain IPB001254 Serine protease IPB001314 Chymotrypsin serine protease family (S1) signature
UniProtKB/Swiss-Prot: TM11B_HUMAN, Q86T26Similarity: Belongs to the peptidase S1 familySimilarity: Contains 1 peptidase S1 domainSimilarity: Contains 1 SEA domain |
Function
for TMPRSS11B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TM11B_HUMAN, Q86T26Function: Probable serine protease (By similarity)Enzyme Number (IUBMB): EC 3.4.21.-1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMPRSS11B (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMPRSS11B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMPRSS11B |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004252 | serine-type endopeptidase activity |
IEA | -- |
TMPRSS11B for ontologies About GeneDecksing
|
Pathways & Interactions
for TMPRSS11B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMPRSS11B
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006508 | proteolysis |
IEA | -- |
TMPRSS11B for ontologies About GeneDecksing
|
Drugs & Compounds
for TMPRSS11B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TMPRSS11B
Search CenterWatch for drugs/clinical trials and news about TMPRSS11B / TM11B
|
Transcripts
for TMPRSS11B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TMPRSS11B gene: NM_182502.3 Unigene Cluster for TMPRSS11B: Transmembrane protease, serine 11B Hs.407122 [show with all ESTs]Unigene Representative Sequence: BX5379453 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000332644(uc003hdw.4) ENST00000510856 ENST00000502365
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMPRSS11B (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMPRSS11B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TMPRSS11B (NM_182502) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMPRSS11B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMPRSS11B |
Additional cDNA sequence: AK290904.1 AK310210.1 AL833167.1 BC126195.1 BX537945.1 3 DOTS entries: DT.75151838 DT.92023309 DT.75159756 9 AceView cDNA sequences: NM_182502 BF188818 AL833167 BX537945 AW117848 BF354411 AL701892 AW263856 AW238624
GeneLoc Exon Structure
|
Expression
for TMPRSS11B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TMPRSS11B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAATCTTGCA
About this image
See TMPRSS11B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TMPRSS11B
SOURCE GeneReport for Unigene cluster: Hs.407122
SABiosciences Custom PCR Arrays for TMPRSS11B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMPRSS11B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat TMPRSS11B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMPRSS11B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMPRSS11B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMPRSS11B |
Orthologs
for TMPRSS11B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for TMPRSS11B gene from 1/7 species (see all 7) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
49(a) |
1 ↔ 1 |
6(58297105-58304622) |
ENSEMBL Gene Tree for TMPRSS11B (if available)
TreeFam Gene Tree for TMPRSS11B (if available) |
Paralogs
for TMPRSS11B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TMPRSS11B gene
- TMPRSS72 TMPRSS52 ST142 TMPRSS42 TMPRSS11D2 TMPRSS132 TMPRSS11E2 TMPRSS32
- TMPRSS22 TMPRSS92 HPN2 TMPRSS152 TMPRSS11F2 TMPRSS11A2 TMPRSS62
18/75 SIMAP similar genes for TMPRSS11B using alignment to 1 protein entry: TM11B_HUMAN(see all similar genes):PRSS1 F2 TMPRSS11D TMPRSS11F HAT TMPRSS11A
PRSS22 HP PROC1 DKFZp586F0824 PROC PRSS8
TMPRSS2 DESC1 F12 CORIN CTRB1 CTRB2
TMPRSS11B for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for TMPRSS11B
PGOHUM00000245558
|
Genomic Variants
for TMPRSS11B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
| | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMPRSS11B |
|
Disorders
/ Diseases
for TMPRSS11B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 TMPRSS11B for disorders About MalaCards
TMPRSS11B for disorders About GeneDecksing
Human Genome Epidemiology (HuGE) Navigator: TMPRSS11B (2 documents)
Export disorders for TMPRSS11B gene to outside databases
|
Publications
for TMPRSS11B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TMPRSS11B gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with TMPRSS11B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Gene variants associated with ischemic stroke: the cardiovascular health study. (PubMed id 19023099)1 Luke M.M....Psaty B.M. (2009)
- Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study. (PubMed id 17975119)1 Shiffman D....Psaty B.M. (2008)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (2006)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336)1 Wiemann S....Poustka A. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1 Wiemann S.... Poustka A. (2001)
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External Searches for TMPRSS11B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TMPRSS11B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TMPRSS11B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TMPRSS11B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TMPRSS11B | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for TMPRSS11B gene:
Search GeneIP for patents involving TMPRSS11B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TMPRSS11B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TMPRSS11B | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMPRSS11B | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMPRSS11B | | | OriGene Protein Over-expression Lysate for TMPRSS11B | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TMPRSS11B | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMPRSS11B | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMPRSS11B | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TMPRSS11B | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMPRSS11B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMPRSS11B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMPRSS11B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMPRSS11B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMPRSS11B |
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 | | | TMPRSS11B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMPRSS11B |
|  |  |  | | | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMPRSS11B |
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