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Aliases for TMPRSS11B Gene

Aliases for TMPRSS11B Gene

  • Transmembrane Protease, Serine 11B 2 3 5
  • Airway Trypsin-Like Protease 5 4
  • EC 3.4.21.- 4
  • HATL5 4

External Ids for TMPRSS11B Gene

Previous GeneCards Identifiers for TMPRSS11B Gene

  • GC04M068923
  • GC04M068774
  • GC04M069092
  • GC04M065004

Summaries for TMPRSS11B Gene

GeneCards Summary for TMPRSS11B Gene

TMPRSS11B (Transmembrane Protease, Serine 11B) is a Protein Coding gene. GO annotations related to this gene include serine-type endopeptidase activity and serine-type peptidase activity. An important paralog of this gene is TMPRSS11A.

UniProtKB/Swiss-Prot for TMPRSS11B Gene

  • Serine protease.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMPRSS11B Gene

Genomics for TMPRSS11B Gene

Regulatory Elements for TMPRSS11B Gene

Genomic Location for TMPRSS11B Gene

Chromosome:
4
Start:
68,226,653 bp from pter
End:
68,245,720 bp from pter
Size:
19,068 bases
Orientation:
Minus strand

Genomic View for TMPRSS11B Gene

Genes around TMPRSS11B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMPRSS11B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMPRSS11B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMPRSS11B Gene

Proteins for TMPRSS11B Gene

  • Protein details for TMPRSS11B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86T26-TM11B_HUMAN
    Recommended name:
    Transmembrane protease serine 11B
    Protein Accession:
    Q86T26
    Secondary Accessions:
    • A8K4D9

    Protein attributes for TMPRSS11B Gene

    Size:
    416 amino acids
    Molecular mass:
    46337 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMPRSS11B Gene

Proteomics data for TMPRSS11B Gene at MOPED

Post-translational modifications for TMPRSS11B Gene

  • Glycosylation at Asn 72, Asn 107, and Asn 315
  • Modification sites at PhosphoSitePlus

Other Protein References for TMPRSS11B Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for TMPRSS11B Gene

Domains & Families for TMPRSS11B Gene

Gene Families for TMPRSS11B Gene

Suggested Antigen Peptide Sequences for TMPRSS11B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86T26

UniProtKB/Swiss-Prot:

TM11B_HUMAN :
  • Contains 1 peptidase S1 domain.
  • Belongs to the peptidase S1 family.
Domain:
  • Contains 1 peptidase S1 domain.
  • Contains 1 SEA domain.
Family:
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with TMPRSS11B: view

Function for TMPRSS11B Gene

Molecular function for TMPRSS11B Gene

UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by aprotinin, leupeptin, benzamidine, SERPINA1, SPINT1 and SPINT2.
UniProtKB/Swiss-Prot Function:
Serine protease.

Enzyme Numbers (IUBMB) for TMPRSS11B Gene

genes like me logo Genes that share phenotypes with TMPRSS11B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMPRSS11B Gene

Localization for TMPRSS11B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMPRSS11B Gene

Cell membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMPRSS11B Gene COMPARTMENTS Subcellular localization image for TMPRSS11B gene
Compartment Confidence
extracellular 5
plasma membrane 5
golgi apparatus 2
endoplasmic reticulum 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for TMPRSS11B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IEA --
genes like me logo Genes that share ontologies with TMPRSS11B: view

Pathways & Interactions for TMPRSS11B Gene

SuperPathways for TMPRSS11B Gene

No Data Available

Interacting Proteins for TMPRSS11B Gene

Gene Ontology (GO) - Biological Process for TMPRSS11B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMPRSS11B Gene

Drugs & Compounds for TMPRSS11B Gene

No Compound Related Data Available

Transcripts for TMPRSS11B Gene

mRNA/cDNA for TMPRSS11B Gene

(3) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMPRSS11B Gene

Transmembrane protease, serine 11B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMPRSS11B Gene

No ASD Table

Relevant External Links for TMPRSS11B Gene

GeneLoc Exon Structure for
TMPRSS11B
ECgene alternative splicing isoforms for
TMPRSS11B

Expression for TMPRSS11B Gene

mRNA expression in normal human tissues for TMPRSS11B Gene

mRNA differential expression in normal tissues according to GTEx for TMPRSS11B Gene

This gene is overexpressed in Esophagus - Mucosa (x34.0), Vagina (x9.2), Cervix - Ectocervix (x4.8), and Minor Salivary Gland (x4.6).

Protein differential expression in normal tissues from HIPED for TMPRSS11B Gene

This gene is overexpressed in Cervix (52.9) and Saliva (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMPRSS11B Gene



SOURCE GeneReport for Unigene cluster for TMPRSS11B Gene Hs.407122

genes like me logo Genes that share expression patterns with TMPRSS11B: view

Protein tissue co-expression partners for TMPRSS11B Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for TMPRSS11B Gene

Orthologs for TMPRSS11B Gene

This gene was present in the common ancestor of animals.

Orthologs for TMPRSS11B Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia TMPRSS11B 35
  • 84.15 (n)
  • 73.41 (a)
TMPRSS11B 36
  • 51 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TMPRSS11B 35
  • 99.36 (n)
  • 98.56 (a)
TMPRSS11B 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 41 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia TMPRSS11B 36
  • 53 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmprss11bnl 36
  • 51 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMPRSS11B 36
  • 50 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 36
  • 38 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 40 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004567 35
  • 47.77 (n)
  • 42.91 (a)
Species with no ortholog for TMPRSS11B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TMPRSS11B Gene

ENSEMBL:
Gene Tree for TMPRSS11B (if available)
TreeFam:
Gene Tree for TMPRSS11B (if available)

Paralogs for TMPRSS11B Gene

Pseudogenes.org Pseudogenes for TMPRSS11B Gene

genes like me logo Genes that share paralogs with TMPRSS11B: view

Variants for TMPRSS11B Gene

Sequence variations from dbSNP and Humsavar for TMPRSS11B Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs12331141 - 68,229,479(+) TACAA(C/T)TCCAA intron-variant, reference, missense
rs2319797 - 68,228,789(-) CTGAT(A/T)CAATG downstream-variant-500B, reference, missense
rs2319796 - 68,228,857(-) AGAAG(A/C)CTTTT downstream-variant-500B, reference, missense
rs1320266 -- 68,238,226(+) AAAAA(C/T)TGATT intron-variant
rs2319794 -- 68,234,801(-) CTAGA(C/T)GTACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMPRSS11B Gene

Variant ID Type Subtype PubMed ID
nsv520487 CNV Loss 19592680

Variation tolerance for TMPRSS11B Gene

Residual Variation Intolerance Score: 71.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.31; 26.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMPRSS11B Gene

HapMap Linkage Disequilibrium report
TMPRSS11B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMPRSS11B Gene

Disorders for TMPRSS11B Gene

Relevant External Links for TMPRSS11B

Genetic Association Database (GAD)
TMPRSS11B
Human Genome Epidemiology (HuGE) Navigator
TMPRSS11B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMPRSS11B

No disorders were found for TMPRSS11B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMPRSS11B Gene

Publications for TMPRSS11B Gene

  1. HATL5: a cell surface serine protease differentially expressed in epithelial cancers. (PMID: 24498351) Miller G.S. … List K. (PLoS ONE 2014) 3 4 67
  2. Gene variants associated with ischemic stroke: the cardiovascular health study. (PMID: 19023099) Luke M.M. … Psaty B.M. (Stroke 2009) 3
  3. Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). (PMID: 19199708) Gonzalez-Begne M. … Yates J.R. (J. Proteome Res. 2009) 3
  4. Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study. (PMID: 17975119) Shiffman D. … Psaty B.M. (Arterioscler. Thromb. Vasc. Biol. 2008) 3
  5. The LIFEdb database in 2006. (PMID: 16381901) Mehrle A. … Wiemann S. (Nucleic Acids Res. 2006) 3

Products for TMPRSS11B Gene

Sources for TMPRSS11B Gene

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