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Aliases for TMPRSS11A Gene

Aliases for TMPRSS11A Gene

  • Transmembrane Protease, Serine 11A 2 3 5
  • Epidermal Type-II Transmembrane Serine Protease 3 4
  • Esophageal Cancer-Susceptibility Gene 1 Protein 3 4
  • Airway Trypsin-Like Protease 1 3 4
  • ECRG1 3 4
  • Epidermal Type II Transmembrane Serine Protease 3
  • EC 3.4.21.- 4
  • EC 3.4.21 63
  • HATL1 4
  • HESP 4

External Ids for TMPRSS11A Gene

Previous GeneCards Identifiers for TMPRSS11A Gene

  • GC04M068605
  • GC04M068459
  • GC04M068776
  • GC04M064689

Summaries for TMPRSS11A Gene

GeneCards Summary for TMPRSS11A Gene

TMPRSS11A (Transmembrane Protease, Serine 11A) is a Protein Coding gene. Diseases associated with TMPRSS11A include esophageal cancer and ichthyosis, follicular. GO annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is KLKB1.

UniProtKB/Swiss-Prot for TMPRSS11A Gene

  • Probable serine protease which may play a role in cellular senescence. Overexpression inhibits cell growth and induce G1 cell cycle arrest.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMPRSS11A Gene

Genomics for TMPRSS11A Gene

Regulatory Elements for TMPRSS11A Gene

Genomic Location for TMPRSS11A Gene

Chromosome:
4
Start:
67,909,385 bp from pter
End:
67,964,140 bp from pter
Size:
54,756 bases
Orientation:
Minus strand

Genomic View for TMPRSS11A Gene

Genes around TMPRSS11A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMPRSS11A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMPRSS11A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMPRSS11A Gene

Proteins for TMPRSS11A Gene

  • Protein details for TMPRSS11A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZMR5-TM11A_HUMAN
    Recommended name:
    Transmembrane protease serine 11A
    Protein Accession:
    Q6ZMR5
    Secondary Accessions:
    • J3KNQ8
    • Q2NKI9
    • Q6JE90
    • Q7RTY4
    • Q86TK8

    Protein attributes for TMPRSS11A Gene

    Size:
    421 amino acids
    Molecular mass:
    47569 Da
    Quaternary structure:
    • May interact with ZBTB17.
    SequenceCaution:
    • Sequence=AAD41463.1; Type=Frameshift; Positions=371; Evidence={ECO:0000305}; Sequence=CAD67985.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for TMPRSS11A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMPRSS11A Gene

Proteomics data for TMPRSS11A Gene at MOPED

Selected DME Specific Peptides for TMPRSS11A Gene

Post-translational modifications for TMPRSS11A Gene

  • Glycosylation at Asn 156 and Asn 306
  • Modification sites at PhosphoSitePlus

Other Protein References for TMPRSS11A Gene

Domains & Families for TMPRSS11A Gene

Gene Families for TMPRSS11A Gene

Suggested Antigen Peptide Sequences for TMPRSS11A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6ZMR5

UniProtKB/Swiss-Prot:

TM11A_HUMAN :
  • Contains 1 peptidase S1 domain.
  • Belongs to the peptidase S1 family.
Domain:
  • Contains 1 peptidase S1 domain.
  • Contains 1 SEA domain.
Family:
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with TMPRSS11A: view

Function for TMPRSS11A Gene

Molecular function for TMPRSS11A Gene

UniProtKB/Swiss-Prot Function:
Probable serine protease which may play a role in cellular senescence. Overexpression inhibits cell growth and induce G1 cell cycle arrest.

Enzyme Numbers (IUBMB) for TMPRSS11A Gene

genes like me logo Genes that share phenotypes with TMPRSS11A: view

Animal Models for TMPRSS11A Gene

MGI Knock Outs for TMPRSS11A:

Animal Model Products

CRISPR Products

miRNA for TMPRSS11A Gene

miRTarBase miRNAs that target TMPRSS11A

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TMPRSS11A Gene

Localization for TMPRSS11A Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMPRSS11A Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMPRSS11A Gene COMPARTMENTS Subcellular localization image for TMPRSS11A gene
Compartment Confidence
extracellular 3
golgi apparatus 2
plasma membrane 2
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for TMPRSS11A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMPRSS11A: view

Pathways & Interactions for TMPRSS11A Gene

SuperPathways for TMPRSS11A Gene

No Data Available

Interacting Proteins for TMPRSS11A Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000334611%0d%0a9606.ENSP00000364895%0d%0a9606.ENSP00000367207%0d%0a9606.ENSP00000223095%0d%0a
Selected Interacting proteins: ENSP00000334611 Q6ZMR5-TM11A_HUMAN for TMPRSS11A Gene via STRING I2D

Gene Ontology (GO) - Biological Process for TMPRSS11A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMPRSS11A Gene

Drugs & Compounds for TMPRSS11A Gene

(1) Drugs for TMPRSS11A Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with TMPRSS11A: view

Transcripts for TMPRSS11A Gene

mRNA/cDNA for TMPRSS11A Gene

(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMPRSS11A Gene

Transmembrane protease, serine 11A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMPRSS11A Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b
SP1: -
SP2:
SP3: - -

Relevant External Links for TMPRSS11A Gene

GeneLoc Exon Structure for
TMPRSS11A
ECgene alternative splicing isoforms for
TMPRSS11A

Expression for TMPRSS11A Gene

mRNA expression in normal human tissues for TMPRSS11A Gene

mRNA differential expression in normal tissues according to GTEx for TMPRSS11A Gene

This gene is overexpressed in Esophagus - Mucosa (x21.1), Vagina (x13.5), Minor Salivary Gland (x10.6), and Cervix - Ectocervix (x7.2).

Protein differential expression in normal tissues from HIPED for TMPRSS11A Gene

This gene is overexpressed in Cervix (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TMPRSS11A Gene



SOURCE GeneReport for Unigene cluster for TMPRSS11A Gene Hs.450110

mRNA Expression by UniProt/SwissProt for TMPRSS11A Gene

Q6ZMR5-TM11A_HUMAN
Tissue specificity: Expressed in esophagus, liver, colon and lung. Down-regulated in esophagus cancers.
genes like me logo Genes that share expression patterns with TMPRSS11A: view

Protein tissue co-expression partners for TMPRSS11A Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for TMPRSS11A Gene

Orthologs for TMPRSS11A Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMPRSS11A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMPRSS11A 36
  • 99 (a)
OneToOne
TMPRSS11A 35
  • 99.28 (n)
  • 99.28 (a)
cow
(Bos Taurus)
Mammalia TMPRSS11A 35
  • 85.29 (n)
  • 78.42 (a)
TMPRSS11A 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMPRSS11A 36
  • 79 (a)
OneToOne
TMPRSS11A 35
  • 85.93 (n)
  • 79.62 (a)
mouse
(Mus musculus)
Mammalia Tmprss11a 16
Tmprss11a 36
  • 70 (a)
OneToOne
Tmprss11a 35
  • 80 (n)
  • 70.65 (a)
oppossum
(Monodelphis domestica)
Mammalia TMPRSS11A 36
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMPRSS11A 36
  • 63 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmprss11a 35
  • 76.71 (n)
  • 68.31 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 41 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 43 (a)
OneToMany
Species with no ortholog for TMPRSS11A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TMPRSS11A Gene

ENSEMBL:
Gene Tree for TMPRSS11A (if available)
TreeFam:
Gene Tree for TMPRSS11A (if available)

Paralogs for TMPRSS11A Gene

Pseudogenes.org Pseudogenes for TMPRSS11A Gene

genes like me logo Genes that share paralogs with TMPRSS11A: view

Variants for TMPRSS11A Gene

Sequence variations from dbSNP and Humsavar for TMPRSS11A Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs353163 - 67,919,056(-) ACGCC(A/G)GATTT reference, missense
rs168482 -- 67,943,249(+) CTTCT(C/T)TTAAG intron-variant
rs189536 -- 67,920,283(-) AGGCA(C/G)ATATG intron-variant
rs353150 -- 67,928,997(-) ATAGT(A/G)TCATA intron-variant
rs353151 -- 67,928,326(-) GCTCA(A/C)GCCTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMPRSS11A Gene

Variant ID Type Subtype PubMed ID
nsv879214 CNV Gain 21882294
nsv829960 CNV Loss 17160897
nsv879219 CNV Loss 21882294
dgv1625e1 CNV Complex 17122850
esv22957 CNV Gain 19812545
nsv10514 CNV Gain 18304495
esv35010 CNV Gain 17911159
esv273097 CNV Insertion 20981092
nsv514221 CNV Gain 21397061
dgv658n27 CNV Loss 19166990
nsv470043 CNV Loss 18288195
nsv433367 CNV Gain 18776910
nsv818242 CNV Gain 17921354
nsv469718 CNV Gain 16826518

Variation tolerance for TMPRSS11A Gene

Residual Variation Intolerance Score: 83.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.06; 68.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMPRSS11A Gene

HapMap Linkage Disequilibrium report
TMPRSS11A
Human Gene Mutation Database (HGMD)
TMPRSS11A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMPRSS11A Gene

Disorders for TMPRSS11A Gene

MalaCards: The human disease database

(5) MalaCards diseases for TMPRSS11A Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
esophageal cancer
  • esophageal cancer, somatic
ichthyosis, follicular
  • follicular ichthyosis
iron-refractory iron deficiency anemia
  • anemia, hypochromic microcytic, with defect in iron metabolism
avian influenza
  • avian flu
clonorchiasis
  • oriental liver fluke disease
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TMPRSS11A

Genetic Association Database (GAD)
TMPRSS11A
Human Genome Epidemiology (HuGE) Navigator
TMPRSS11A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMPRSS11A
genes like me logo Genes that share disorders with TMPRSS11A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TMPRSS11A Gene

Publications for TMPRSS11A Gene

  1. Mouse DESC1 is located within a cluster of seven DESC1-like genes and encodes a type II transmembrane serine protease that forms serpin inhibitory complexes. (PMID: 15328353) Hobson J.P. … Bugge T.H. (J. Biol. Chem. 2004) 2 3 23 67
  2. ECRG1, a novel esophageal gene, cloned and identified from human esophagus and its inhibition effect on tumors. (PMID: 17971341) Yueying W. … Shih-Hsin L. (Carcinogenesis 2008) 3 23
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Modification of risk, but not survival of esophageal cancer patients by esophageal cancer-related gene 1 Arg290Gln polymorphism: a case-control study and meta-analysis. (PMID: 23869757) Umar M. … Mittal B. (J. Gastroenterol. Hepatol. 2013) 3
  5. ECRG1 and its relationship with esophageal cancer: a brief review. (PMID: 23548972) Rasool S. … Ganai B.A. (Onkologie 2013) 3

Products for TMPRSS11A Gene

Sources for TMPRSS11A Gene

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