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Aliases for TMPPE Gene

Aliases for TMPPE Gene

  • Transmembrane Protein With Metallophosphoesterase Domain 2 3 5
  • EC 3.1.-.- 4

External Ids for TMPPE Gene

Previous GeneCards Identifiers for TMPPE Gene

  • GC03M033108

Summaries for TMPPE Gene

GeneCards Summary for TMPPE Gene

TMPPE (Transmembrane Protein With Metallophosphoesterase Domain) is a Protein Coding gene. GO annotations related to this gene include hydrolase activity.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMPPE Gene

Genomics for TMPPE Gene

Regulatory Elements for TMPPE Gene

Enhancers for TMPPE Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F033054 1.4 Ensembl ENCODE 11.3 +41.7 41735 1.9 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 YY1 ZNF143 ZNF207 TMPPE GLB1 SUGT1P2 CNOT10-AS1 CNOT10 UBP1 CRTAP SEC13P1 SUMO2P10
GH03F033095 1.1 ENCODE 14.3 -0.2 -238 3.1 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 YY1 SP3 SP5 TMPPE PDCD6IP ENSG00000271643 ENSG00000236732 ENSG00000271020 CRTAP GLB1
GH03F033113 1.1 ENCODE 13.9 -17.9 -17906 3.1 ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 FOS ZNF263 SP3 CRTAP PDCD6IP TMPPE GLB1 ENSG00000271643 ENSG00000236732 ENSG00000271020 GC03P033114 PIR55934
GH03F033437 1.2 ENCODE 10.7 -343.1 -343136 5.5 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 PDCD6IP UBP1 FBXL2 TMPPE CMTM6 PIR40256 GC03M033417
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMPPE on UCSC Golden Path with GeneCards custom track

Genomic Location for TMPPE Gene

33,090,416 bp from pter
33,096,801 bp from pter
6,386 bases
Minus strand

Genomic View for TMPPE Gene

Genes around TMPPE on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMPPE Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMPPE Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMPPE Gene

Proteins for TMPPE Gene

  • Protein details for TMPPE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein with metallophosphoesterase domain
    Protein Accession:
    Secondary Accessions:
    • B2RNG5
    • Q6ZRG1

    Protein attributes for TMPPE Gene

    453 amino acids
    Molecular mass:
    49453 Da
    Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMPPE Gene


neXtProt entry for TMPPE Gene

Post-translational modifications for TMPPE Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMPPE Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMPPE Gene

Domains & Families for TMPPE Gene

Protein Domains for TMPPE Gene

Suggested Antigen Peptide Sequences for TMPPE Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the metallophosphoesterase superfamily. LOC643853 family.
  • Belongs to the metallophosphoesterase superfamily. LOC643853 family.
genes like me logo Genes that share domains with TMPPE: view

No data available for Gene Families for TMPPE Gene

Function for TMPPE Gene

Enzyme Numbers (IUBMB) for TMPPE Gene

Gene Ontology (GO) - Molecular Function for TMPPE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016787 hydrolase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with TMPPE: view
genes like me logo Genes that share phenotypes with TMPPE: view

Animal Model Products

miRNA for TMPPE Gene

miRTarBase miRNAs that target TMPPE

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMPPE Gene

Localization for TMPPE Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMPPE Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMPPE gene
Compartment Confidence
plasma membrane 3
mitochondrion 2
nucleus 2
cytosol 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for TMPPE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMPPE: view

Pathways & Interactions for TMPPE Gene

SuperPathways for TMPPE Gene

No Data Available

Interacting Proteins for TMPPE Gene

Gene Ontology (GO) - Biological Process for TMPPE Gene


No data available for Pathways by source and SIGNOR curated interactions for TMPPE Gene

Transcripts for TMPPE Gene

mRNA/cDNA for TMPPE Gene

(2) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMPPE Gene

No ASD Table

Relevant External Links for TMPPE Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMPPE Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TMPPE Gene

Protein differential expression in normal tissues from HIPED for TMPPE Gene

This gene is overexpressed in Peripheral blood mononuclear cells (21.2) and Retina (15.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TMPPE Gene

Protein tissue co-expression partners for TMPPE Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TMPPE Gene:

genes like me logo Genes that share expression patterns with TMPPE: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TMPPE Gene

Orthologs for TMPPE Gene

This gene was present in the common ancestor of animals.

Orthologs for TMPPE Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMPPE 34
  • 99.34 (n)
(Bos Taurus)
Mammalia TMPPE 34
  • 85.29 (n)
(Mus musculus)
Mammalia Tmppe 34 16 35
  • 83.52 (n)
(Rattus norvegicus)
Mammalia LOC102555172 34
  • 82.55 (n)
(Ornithorhynchus anatinus)
Mammalia TMPPE 35
  • 69 (a)
(Gallus gallus)
Aves TMPPE 34
  • 66.82 (n)
(Danio rerio)
Actinopterygii tmppe 34 35
  • 58.68 (n)
(Caenorhabditis elegans)
Secernentea F40B5.2 34 35
  • 47.51 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 46 (a)
Species where no ortholog for TMPPE was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TMPPE Gene

Gene Tree for TMPPE (if available)
Gene Tree for TMPPE (if available)

Paralogs for TMPPE Gene

No data available for Paralogs for TMPPE Gene

Variants for TMPPE Gene

Sequence variations from dbSNP and Humsavar for TMPPE Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs398123356 Pathogenic 33,097,034(-) TGCTT(-/T)CTGGG upstream-variant-2KB, reference, frameshift-variant
rs398123358 Pathogenic 33,097,010(-) TGCGC(C/G)TAAGT upstream-variant-2KB, splice-donor-variant
rs587776525 Pathogenic 33,097,009(+) ACTTA(-/A)CGCGC upstream-variant-2KB, splice-donor-variant
rs794726886 Likely pathogenic 33,097,085(-) TGGTC(A/C)TGCCG upstream-variant-2KB, reference, missense
rs879253739 Likely pathogenic 33,097,006(-) CGTAA(C/G)TCTGC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TMPPE Gene

Variant ID Type Subtype PubMed ID
nsv998302 CNV gain 25217958
nsv590050 CNV loss 21841781
nsv1003285 CNV gain 25217958

Variation tolerance for TMPPE Gene

Residual Variation Intolerance Score: 33% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.94; 59.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMPPE Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMPPE Gene

Disorders for TMPPE Gene

Relevant External Links for TMPPE

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TMPPE Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMPPE Gene

Publications for TMPPE Gene

  1. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for TMPPE Gene

Sources for TMPPE Gene

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