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Aliases for TMPPE Gene

Aliases for TMPPE Gene

  • Transmembrane Protein With Metallophosphoesterase Domain 2 3
  • EC 3.1.-.- 4

External Ids for TMPPE Gene

Previous GeneCards Identifiers for TMPPE Gene

  • GC03M033108

Summaries for TMPPE Gene

GeneCards Summary for TMPPE Gene

TMPPE is a Protein Coding gene. GO annotations related to this gene include hydrolase activity.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMPPE Gene

Genomics for TMPPE Gene

Regulatory Elements for TMPPE Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TMPPE Gene

33,090,416 bp from pter
33,096,801 bp from pter
6,386 bases
Minus strand

Genomic View for TMPPE Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMPPE Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMPPE Gene

Proteins for TMPPE Gene

  • Protein details for TMPPE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein with metallophosphoesterase domain
    Protein Accession:
    Secondary Accessions:
    • B2RNG5
    • Q6ZRG1

    Protein attributes for TMPPE Gene

    453 amino acids
    Molecular mass:
    49453 Da
    Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240; Note=Binds 2 divalent metal cations.;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMPPE Gene


neXtProt entry for TMPPE Gene

Proteomics data for TMPPE Gene at MOPED

Post-translational modifications for TMPPE Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMPPE Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMPPE Gene

Domains for TMPPE Gene

Protein Domains for TMPPE Gene

Suggested Antigen Peptide Sequences for TMPPE Gene

Graphical View of Domain Structure for InterPro Entry



  • Q6ZT21
  • Belongs to the metallophosphoesterase superfamily. LOC643853 family.
genes like me logo Genes that share domains with TMPPE: view

No data available for Gene Families for TMPPE Gene

Function for TMPPE Gene

Enzyme Numbers (IUBMB) for TMPPE Gene

Gene Ontology (GO) - Molecular Function for TMPPE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016787 hydrolase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with TMPPE: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TMPPE Gene

Localization for TMPPE Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMPPE Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for TMPPE Gene COMPARTMENTS Subcellular localization image for TMPPE gene
Compartment Confidence
plasma membrane 3
endoplasmic reticulum 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for TMPPE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMPPE: view

Pathways for TMPPE Gene

SuperPathways for TMPPE Gene

No Data Available

Interacting Proteins for TMPPE Gene

Gene Ontology (GO) - Biological Process for TMPPE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with TMPPE: view

No data available for Pathways by source for TMPPE Gene

Transcripts for TMPPE Gene

mRNA/cDNA for TMPPE Gene

(2) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMPPE

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMPPE Gene

No ASD Table

Relevant External Links for TMPPE Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMPPE Gene

mRNA expression in normal human tissues for TMPPE Gene

Protein differential expression in normal tissues for TMPPE Gene

This gene is overexpressed in Peripheral blood mononuclear cells (21.2) and Retina (15.3).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for TMPPE Gene

genes like me logo Genes that share expressions with TMPPE: view

Expression partners for TMPPE Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TMPPE Gene

Orthologs for TMPPE Gene

This gene was present in the common ancestor of animals.

Orthologs for TMPPE Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TMPPE 35
  • 85.29 (n)
  • 87.39 (a)
(Mus musculus)
Mammalia Tmppe 35
  • 83.52 (n)
  • 86.29 (a)
Tmppe 16
Tmppe 36
  • 86 (a)
(Pan troglodytes)
Mammalia TMPPE 35
  • 99.34 (n)
  • 99.12 (a)
(Rattus norvegicus)
Mammalia LOC102555172 35
  • 82.55 (n)
  • 86.35 (a)
(Ornithorhynchus anatinus)
Mammalia TMPPE 36
  • 69 (a)
(Gallus gallus)
Aves TMPPE 35
  • 66.82 (n)
  • 69.02 (a)
(Danio rerio)
Actinopterygii tmppe 35
  • 58.68 (n)
  • 55.58 (a)
tmppe 36
  • 54 (a)
(Caenorhabditis elegans)
Secernentea F40B5.2 35
  • 47.51 (n)
  • 37.22 (a)
F40B5.2 36
  • 32 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 46 (a)
Species with no ortholog for TMPPE:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TMPPE Gene

Gene Tree for TMPPE (if available)
Gene Tree for TMPPE (if available)

Paralogs for TMPPE Gene

No data available for Paralogs for TMPPE Gene

Variants for TMPPE Gene

Relevant External Links for TMPPE Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for TMPPE Gene

Disorders for TMPPE Gene

No disorders were found for TMPPE Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for TMPPE Gene

Publications for TMPPE Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4

Products for TMPPE Gene

Sources for TMPPE Gene

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