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Aliases for TMPPE Gene

Aliases for TMPPE Gene

  • Transmembrane Protein With Metallophosphoesterase Domain 2 3 5
  • EC 3.1.-.- 4

External Ids for TMPPE Gene

Previous GeneCards Identifiers for TMPPE Gene

  • GC03M033108

Summaries for TMPPE Gene

GeneCards Summary for TMPPE Gene

TMPPE (Transmembrane Protein With Metallophosphoesterase Domain) is a Protein Coding gene. GO annotations related to this gene include hydrolase activity.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMPPE Gene

Genomics for TMPPE Gene

Regulatory Elements for TMPPE Gene

Enhancers for TMPPE Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TMPPE on UCSC Golden Path with GeneCards custom track

Promoters for TMPPE Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TMPPE on UCSC Golden Path with GeneCards custom track

Genomic Location for TMPPE Gene

33,090,416 bp from pter
33,096,801 bp from pter
6,386 bases
Minus strand

Genomic View for TMPPE Gene

Genes around TMPPE on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMPPE Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMPPE Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMPPE Gene

Proteins for TMPPE Gene

  • Protein details for TMPPE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein with metallophosphoesterase domain
    Protein Accession:
    Secondary Accessions:
    • B2RNG5
    • Q6ZRG1

    Protein attributes for TMPPE Gene

    453 amino acids
    Molecular mass:
    49453 Da
    Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMPPE Gene


neXtProt entry for TMPPE Gene

Proteomics data for TMPPE Gene at MOPED

Post-translational modifications for TMPPE Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMPPE Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMPPE Gene

Domains & Families for TMPPE Gene

Protein Domains for TMPPE Gene

Suggested Antigen Peptide Sequences for TMPPE Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the metallophosphoesterase superfamily. LOC643853 family.
  • Belongs to the metallophosphoesterase superfamily. LOC643853 family.
genes like me logo Genes that share domains with TMPPE: view

No data available for Gene Families for TMPPE Gene

Function for TMPPE Gene

Enzyme Numbers (IUBMB) for TMPPE Gene

Gene Ontology (GO) - Molecular Function for TMPPE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with TMPPE: view
genes like me logo Genes that share phenotypes with TMPPE: view

Animal Model Products

CRISPR Products

miRNA for TMPPE Gene

miRTarBase miRNAs that target TMPPE

No data available for Molecular function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMPPE Gene

Localization for TMPPE Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMPPE Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for TMPPE Gene COMPARTMENTS Subcellular localization image for TMPPE gene
Compartment Confidence
plasma membrane 3
cytosol 2
mitochondrion 2
nucleus 2
endoplasmic reticulum 1

No data available for Gene Ontology (GO) - Cellular Components for TMPPE Gene

Pathways & Interactions for TMPPE Gene

SuperPathways for TMPPE Gene

No Data Available

Interacting Proteins for TMPPE Gene

Gene Ontology (GO) - Biological Process for TMPPE Gene


No data available for Pathways by source and SIGNOR curated interactions for TMPPE Gene

Drugs & Compounds for TMPPE Gene

No Compound Related Data Available

Transcripts for TMPPE Gene

mRNA/cDNA for TMPPE Gene

(2) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for TMPPE Gene

No ASD Table

Relevant External Links for TMPPE Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMPPE Gene

mRNA expression in normal human tissues for TMPPE Gene

Protein differential expression in normal tissues from HIPED for TMPPE Gene

This gene is overexpressed in Peripheral blood mononuclear cells (21.2) and Retina (15.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for TMPPE Gene

genes like me logo Genes that share expression patterns with TMPPE: view

Protein tissue co-expression partners for TMPPE Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TMPPE Gene

Orthologs for TMPPE Gene

This gene was present in the common ancestor of animals.

Orthologs for TMPPE Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TMPPE 35
  • 85.29 (n)
  • 87.39 (a)
(Mus musculus)
Mammalia Tmppe 35
  • 83.52 (n)
  • 86.29 (a)
Tmppe 16
Tmppe 36
  • 86 (a)
(Pan troglodytes)
Mammalia TMPPE 35
  • 99.34 (n)
  • 99.12 (a)
(Rattus norvegicus)
Mammalia LOC102555172 35
  • 82.55 (n)
  • 86.35 (a)
(Ornithorhynchus anatinus)
Mammalia TMPPE 36
  • 69 (a)
(Gallus gallus)
Aves TMPPE 35
  • 66.82 (n)
  • 69.02 (a)
(Danio rerio)
Actinopterygii tmppe 35
  • 58.68 (n)
  • 55.58 (a)
tmppe 36
  • 54 (a)
(Caenorhabditis elegans)
Secernentea F40B5.2 35
  • 47.51 (n)
  • 37.22 (a)
F40B5.2 36
  • 32 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 46 (a)
Species with no ortholog for TMPPE:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TMPPE Gene

Gene Tree for TMPPE (if available)
Gene Tree for TMPPE (if available)

Paralogs for TMPPE Gene

No data available for Paralogs for TMPPE Gene

Variants for TMPPE Gene

Variation tolerance for TMPPE Gene

Residual Variation Intolerance Score: 33% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.94; 59.59% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for TMPPE Gene

Disorders for TMPPE Gene

Relevant External Links for TMPPE

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TMPPE Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMPPE Gene

Publications for TMPPE Gene

  1. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for TMPPE Gene

Sources for TMPPE Gene