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Aliases for TMPO Gene

Aliases for TMPO Gene

  • Thymopoietin 2 3 3 5
  • Thymopoietin-Related Peptide Isoforms Beta/Gamma 3 4
  • Thymopoietin-Related Peptide Isoform Alpha 3 4
  • LEM Domain Containing 4 2 3
  • TP Beta/Gamma 3 4
  • TP Alpha 3 4
  • LAP2 3 4
  • Thymopoietin, Isoforms Beta/Gamma 4
  • Lamina-Associated Polypeptide 2 3
  • Thymopoietin Isoform Alpha 4
  • TPRP Isoforms Beta/Gamma 4
  • TPRP Isoform Alpha 4
  • Thymopoietin Beta 3
  • PRO0868 3
  • CMD1T 3
  • LEMD4 3
  • TP 3

External Ids for TMPO Gene

Previous GeneCards Identifiers for TMPO Gene

  • GC12M098312
  • GC12P099412
  • GC12P098842
  • GC12P097411
  • GC12P098909
  • GC12P095970

Summaries for TMPO Gene

Entrez Gene Summary for TMPO Gene

  • The protein encoded by this gene resides in the nucleus and may play a role in the assembly of the nuclear lamina, and thus help maintain the structural organization of the nuclear envelope. It may function as a receptor for the attachment of lamin filaments to the inner nuclear membrane. Mutations in this gene are associated with dilated cardiomyopathy. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, May 2010]

GeneCards Summary for TMPO Gene

TMPO (Thymopoietin) is a Protein Coding gene. Diseases associated with TMPO include Cardiomyopathy, Dilated, 1T and Tmpo-Related Dilated Cardiomyopathy. Among its related pathways are Regulation of Glucokinase by Glucokinase Regulatory Protein and Cytoskeletal Signaling. GO annotations related to this gene include lamin binding.

UniProtKB/Swiss-Prot for TMPO Gene

  • May be involved in the structural organization of the nucleus and in the post-mitotic nuclear assembly. Plays an important role, together with LMNA, in the nuclear anchorage of RB1.

  • TP and TP5 may play a role in T-cell development and function. TP5 is an immunomodulating pentapeptide.

  • May help direct the assembly of the nuclear lamina and thereby help maintain the structural organization of the nuclear envelope. Possible receptor for attachment of lamin filaments to the inner nuclear membrane. May be involved in the control of initiation of DNA replication through its interaction with NAKAP95.

  • Thymopoietin (TP) and Thymopentin (TP5) may play a role in T-cell development and function. TP5 is an immunomodulating pentapeptide.

Gene Wiki entry for TMPO Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMPO Gene

Genomics for TMPO Gene

Regulatory Elements for TMPO Gene

Enhancers for TMPO Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around TMPO on UCSC Golden Path with GeneCards custom track

Promoters for TMPO Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TMPO on UCSC Golden Path with GeneCards custom track

Genomic Location for TMPO Gene

Chromosome:
12
Start:
98,515,512 bp from pter
End:
98,550,379 bp from pter
Size:
34,868 bases
Orientation:
Plus strand

Genomic View for TMPO Gene

Genes around TMPO on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMPO Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMPO Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMPO Gene

Proteins for TMPO Gene

  • Protein details for TMPO Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P42166-LAP2A_HUMAN
    Recommended name:
    Lamina-associated polypeptide 2, isoform alpha
    Protein Accession:
    P42166
    Secondary Accessions:
    • P08918
    • P08919
    • Q14860
    • Q16295

    Protein attributes for TMPO Gene

    Size:
    694 amino acids
    Molecular mass:
    75492 Da
    Quaternary structure:
    • Interacts with LMNA, BANF1 and RB1 and with chromosomes. Associates directly or indirectly with lamins at specific cell-cycle stages.

    Three dimensional structures from OCA and Proteopedia for TMPO Gene

    Alternative splice isoforms for TMPO Gene

    UniProtKB/Swiss-Prot:
  • Protein details for TMPO Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P42167-LAP2B_HUMAN
    Recommended name:
    Lamina-associated polypeptide 2, isoforms beta/gamma
    Protein Accession:
    P42167
    Secondary Accessions:
    • A2T926
    • Q14861

    Protein attributes for TMPO Gene

    Size:
    454 amino acids
    Molecular mass:
    50670 Da
    Quaternary structure:
    • Interacts with LMNB1, LMNB2, BANF1, AKAP8L, GMCL and chromosomes (By similarity). Isoform Zeta interacts with BANF1/BAF and may sequester it in the cytoplasm.

    Alternative splice isoforms for TMPO Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMPO Gene

Post-translational modifications for TMPO Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for TMPO (TMPO iso6)

No data available for DME Specific Peptides for TMPO Gene

Domains & Families for TMPO Gene

Gene Families for TMPO Gene

Graphical View of Domain Structure for InterPro Entry

P42166

UniProtKB/Swiss-Prot:

LAP2B_HUMAN :
  • The N-terminal part contains two structurally independent, non-interacting domains: LEM-like (also called LAP2-N or LEM-D) and LEM (also called LAP2-C or LEM-B). LEM-like binds DNA while LEM interacts with BANF1.
  • Belongs to the LEM family.
Domain:
  • The N-terminal part contains two structurally independent, non-interacting domains: LEM-like (also called LAP2-N or LEM-D) and LEM (also called LAP2-C or LEM-B). LEM-like binds DNA while LEM interacts with BANF1.
  • The C-terminal domain forms a four-stranded coiled coil.
  • Contains 1 LEM domain.
  • Contains 1 LEM-like domain.
  • Has two structurally independent, non-interacting domains: LEM-like (also called LAP2-N or LEM-D) and LEM (also called LAP2-C or LEM-B). LEM-like binds DNA while LEM interacts with BANF1.
Family:
  • Belongs to the LEM family.
genes like me logo Genes that share domains with TMPO: view

Function for TMPO Gene

Molecular function for TMPO Gene

GENATLAS Biochemistry:
thymopoietin,nuclear precursor of subunits alpha (75kDa),beta (51kDa),gamma (39kDa),LAP2 (lamina-associated protein 2) family
UniProtKB/Swiss-Prot Function:
May be involved in the structural organization of the nucleus and in the post-mitotic nuclear assembly. Plays an important role, together with LMNA, in the nuclear anchorage of RB1.
UniProtKB/Swiss-Prot Function:
TP and TP5 may play a role in T-cell development and function. TP5 is an immunomodulating pentapeptide.
UniProtKB/Swiss-Prot Function:
May help direct the assembly of the nuclear lamina and thereby help maintain the structural organization of the nuclear envelope. Possible receptor for attachment of lamin filaments to the inner nuclear membrane. May be involved in the control of initiation of DNA replication through its interaction with NAKAP95.
UniProtKB/Swiss-Prot Function:
Thymopoietin (TP) and Thymopentin (TP5) may play a role in T-cell development and function. TP5 is an immunomodulating pentapeptide.

Gene Ontology (GO) - Molecular Function for TMPO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IEA --
GO:0005521 lamin binding TAS 8530026
GO:0098641 cadherin binding involved in cell-cell adhesion IDA 25468996
genes like me logo Genes that share ontologies with TMPO: view
genes like me logo Genes that share phenotypes with TMPO: view

Human Phenotype Ontology for TMPO Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for TMPO Gene

MGI Knock Outs for TMPO:

Animal Model Products

CRISPR Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for TMPO Gene

Localization for TMPO Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMPO Gene

Nucleus. Chromosome. Note=Expressed diffusely throughout the nucleus.
Nucleus inner membrane; Single-pass type II membrane protein. Note=Tightly associated with the nuclear lamina.
Isoform Zeta: Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMPO Gene COMPARTMENTS Subcellular localization image for TMPO gene
Compartment Confidence
nucleus 5
cytosol 2
endoplasmic reticulum 2
extracellular 1

Gene Ontology (GO) - Cellular Components for TMPO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 chromatin IDA 17284516
GO:0005634 nucleus IDA 17284516
GO:0005635 nuclear envelope IEA,TAS 8530026
GO:0005637 nuclear inner membrane IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
genes like me logo Genes that share ontologies with TMPO: view

Pathways & Interactions for TMPO Gene

genes like me logo Genes that share pathways with TMPO: view

Gene Ontology (GO) - Biological Process for TMPO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0098609 cell-cell adhesion IEA --
genes like me logo Genes that share ontologies with TMPO: view

No data available for SIGNOR curated interactions for TMPO Gene

Drugs & Compounds for TMPO Gene

(18) Drugs for TMPO Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(16) Additional Compounds for TMPO Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TMPO: view

Transcripts for TMPO Gene

Unigene Clusters for TMPO Gene

Thymopoietin:
Representative Sequences:

CRISPR Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMPO Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b
SP1: - - -
SP2: - - - - - -
SP3: -
SP4:
SP5:

Relevant External Links for TMPO Gene

GeneLoc Exon Structure for
TMPO
ECgene alternative splicing isoforms for
TMPO

Expression for TMPO Gene

mRNA expression in normal human tissues for TMPO Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TMPO Gene



Protein tissue co-expression partners for TMPO Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TMPO Gene:

TMPO

SOURCE GeneReport for Unigene cluster for TMPO Gene:

Hs.11355

mRNA Expression by UniProt/SwissProt for TMPO Gene:

P42166-LAP2A_HUMAN
Tissue specificity: Expressed in many tissues. Most abundant in adult thymus and fetal liver.
genes like me logo Genes that share expression patterns with TMPO: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein differential expression in normal tissues for TMPO Gene

Orthologs for TMPO Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMPO Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TMPO 34
  • 75.45 (n)
  • 70.7 (a)
TMPO 35
  • 46 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMPO 34
  • 94.78 (n)
  • 94.48 (a)
TMPO 35
  • 51 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmpo 34
  • 89.75 (n)
  • 91.15 (a)
Tmpo 16
Tmpo 35
  • 80 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TMPO 34
  • 99.71 (n)
  • 99.56 (a)
TMPO 35
  • 52 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmpo 34
  • 89.75 (n)
  • 90.27 (a)
oppossum
(Monodelphis domestica)
Mammalia TMPO 35
  • 42 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMPO 35
  • 38 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMPO 34
  • 80.26 (n)
  • 76.5 (a)
TMPO 35
  • 41 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMPO 35
  • 37 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75950 34
tmpo 34
  • 69.58 (n)
  • 62.17 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.464 34
zebrafish
(Danio rerio)
Actinopterygii tmpo 34
tmpoa 34
  • 59.21 (n)
  • 59.11 (a)
TMPO (3 of 3) 35
  • 28 (a)
OneToMany
tmpoa 35
  • 25 (a)
OneToMany
tmpob 35
  • 30 (a)
OneToMany
Species where no ortholog for TMPO was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMPO Gene

ENSEMBL:
Gene Tree for TMPO (if available)
TreeFam:
Gene Tree for TMPO (if available)

Paralogs for TMPO Gene

Pseudogenes.org Pseudogenes for TMPO Gene

genes like me logo Genes that share paralogs with TMPO: view

No data available for Paralogs for TMPO Gene

Variants for TMPO Gene

Sequence variations from dbSNP and Humsavar for TMPO Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs17459334 - 98,534,052(+) TTAGT(C/G)AAGCT intron-variant, reference, missense
rs35998138 - 98,532,970(+) CGAAC(G/T)ACAGG intron-variant, reference, missense
rs35645287 - 98,533,134(+) GTTCT(G/T)CGTCA intron-variant, reference, missense
rs35969221 - 98,533,207(+) AGAAA(C/G)CACCA intron-variant, reference, missense
rs11838270 - 98,533,503(+) AGTCT(A/G)AGTTT intron-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for TMPO Gene

Variant ID Type Subtype PubMed ID
esv2601754 CNV deletion 19546169
esv2761763 CNV loss 21179565
nsv1040329 CNV gain 25217958
nsv1138163 CNV deletion 24896259
nsv7234 OTHER inversion 18451855
nsv975655 CNV duplication 23825009

Variation tolerance for TMPO Gene

Residual Variation Intolerance Score: 63.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.64; 78.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMPO Gene

Human Gene Mutation Database (HGMD)
TMPO
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMPO

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMPO Gene

Disorders for TMPO Gene

MalaCards: The human disease database

(13) MalaCards diseases for TMPO Gene - From: OMIM, GeneTests, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
cardiomyopathy, dilated, 1t
  • cardiomyopathy, dilated 1t
tmpo-related dilated cardiomyopathy
  • dilated cardiomyopathy 1t
familial isolated dilated cardiomyopathy
  • familial or idiopathic dilated cardiomyopathy
alopecia totalis
  • loss of all scalp hair
dysentery
  • infectious diarrhea
- elite association - COSMIC cancer census association via MalaCards
Search TMPO in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

LAP2B_HUMAN
  • Cardiomyopathy, dilated 1T (CMD1T) [MIM:613740]: A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. {ECO:0000269 PubMed:16247757}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for TMPO

Genetic Association Database (GAD)
TMPO
Human Genome Epidemiology (HuGE) Navigator
TMPO
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMPO
genes like me logo Genes that share disorders with TMPO: view

No data available for Genatlas for TMPO Gene

Publications for TMPO Gene

  1. Three distinct human thymopoietins are derived from alternatively spliced mRNAs. (PMID: 7517549) Harris C.A. … Goldstein G. (Proc. Natl. Acad. Sci. U.S.A. 1994) 2 3 4 22 65
  2. Structure and mapping of the human thymopoietin (TMPO) gene and relationship of human TMPO beta to rat lamin-associated polypeptide 2. (PMID: 8530026) Harris C.A. … Goldstein G. (Genomics 1995) 3 4 22 65
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 65
  4. Genome-wide SNP genotyping study using pooled DNA to identify candidate markers mediating susceptibility to end-stage renal disease attributed to Type 1 diabetes. (PMID: 19929986) Craig D.W. … DiStefano J.K. (Diabet. Med. 2009) 3 46 65
  5. LAP2zeta binds BAF and suppresses LAP2beta-mediated transcriptional repression. (PMID: 18403046) Shaklai S. … Rechavi G. (Eur. J. Cell Biol. 2008) 3 4 65

Products for TMPO Gene

Sources for TMPO Gene

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