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TMPO Gene

protein-coding   GIFtS: 64
GCID: GC12P098909

Thymopoietin

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
thymopoietin1 2     LEMD42
LAP22 3 5     PRO08682
LEM Domain Containing 41 2     TP2
Thymopoietin-Related Peptide Isoform Alpha2 3     Lamina-Associated Polypeptide 22
Thymopoietin-Related Peptide Isoforms Beta/Gamma2 3     Thymopoietin Isoform Alpha3
TP Alpha2 3     Thymopoietin, Isoforms Beta/Gamma3
TP Beta/Gamma2 3     TPRP Isoform Alpha3
CMD1T2 5     TPRP Isoforms Beta/Gamma3

External Ids:    HGNC: 118751   Entrez Gene: 71122   Ensembl: ENSG000001208027   OMIM: 1883805   UniProtKB: P421663   
UniProtKB: P421673   

Export aliases for TMPO gene to outside databases

Previous GC identifers: GC12M098312 GC12P099412 GC12P098842 GC12P097411 GC12P095970


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TMPO Gene:
The protein encoded by this gene resides in the nucleus and may play a role in the assembly of the nuclear lamina,
and thus help maintain the structural organization of the nuclear envelope. It may function as a receptor for the
attachment of lamin filaments to the inner nuclear membrane. Mutations in this gene are associated with dilated
cardiomyopathy. Alternatively spliced transcript variants encoding different isoforms have been noted for this
gene. (provided by RefSeq, May 2010)

GeneCards Summary for TMPO Gene:
TMPO (thymopoietin) is a protein-coding gene. Diseases associated with TMPO include cardiomyopathy, dilated, 1t, and phobic disorder. GO annotations related to this gene include lamin binding.

UniProtKB/Swiss-Prot: LAP2B_HUMAN, P42167
Function: May help direct the assembly of the nuclear lamina and thereby help maintain the structural organization
of the nuclear envelope. Possible receptor for attachment of lamin filaments to the inner nuclear membrane. May
be involved in the control of initiation of DNA replication through its interaction with NAKAP95
Function: TP and TP5 may play a role in T-cell development and function. TP5 is an immunomodulating pentapeptide

Gene Wiki entry for TMPO (Thymopoietin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TMPO gene promoter:
         HEN1   SRY   Pax-5   AP-4   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMPO promoter sequence
   Search Chromatin IP Primers for TMPO

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TMPO


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q22   Ensembl cytogenetic band:  12q23.1   HGNC cytogenetic band: 12q22

TMPO Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMPO gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P098909:  view genomic region     (about GC identifiers)

Start:
98,909,290 bp from pter      End:
98,944,157 bp from pter
Size:
34,868 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: LAP2A_HUMAN, P42166 (See protein sequence)
Recommended Name: Lamina-associated polypeptide 2, isoform alpha  
Size: 694 amino acids; 75492 Da
Subunit: Interacts with LMNA, BANF1 and RB1 and with chromosomes. Associates directly or indirectly with lamins at
specific cell-cycle stages
3 PDB 3D structures from and Proteopedia for TMPO:
1GJJ (3D)        1H9E (3D)        1H9F (3D)    
Secondary accessions: P08918 P08919 Q14860 Q16295
Alternative splicing: 3 isoforms:  P42166-1   P42167-1   P42167-2   

UniProtKB/Swiss-Prot: LAP2B_HUMAN, P42167 (See protein sequence)

Recommended Name: Lamina-associated polypeptide 2, isoforms beta/gamma  
Size: 454 amino acids; 50670 Da
Subunit: Interacts with LMNB1, LMNB2, BANF1, AKAP8L, GMCL and chromosomes (By similarity)
Secondary accessions: Q14861
Alternative splicing: 3 isoforms:  P42167-1   P42166-1   P42167-2   

Explore the universe of human proteins at neXtProt for TMPO: NX_P42167

Explore proteomics data for TMPO at MOPED

Post-translational modifications: 

  • Phosphorylated in a mitose-specific manner1
  • Mitosis-specific phosphorylation specifically abolishes its binding to lamin B and chromosomes (By similarity)1
  • Citrullinated by PADI4 (By similarity)1
  • Ubiquitination2 at Lys213, Lys303, Lys346, Lys389, Lys393, Lys401
  • Modification sites at PhosphoSitePlus

  • See TMPO Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001027454.1  NP_001027455.1  NP_003267.1  

    ENSEMBL proteins: 
     ENSP00000450627   ENSP00000340251   ENSP00000266732   ENSP00000376773   ENSP00000261210  
     ENSP00000451552  

    TMPO Human Recombinant Protein Products:

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    Novus Biologicals TMPO Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for TMPO
    Cloud-Clone Corp. Proteins for TMPO

    TMPO Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of TMPO
    R&D Systems Antibodies for TMPO (Thymopoietin)
    Cell Signaling Technology (CST) Antibodies for TMPO  (TMPO iso6)
    OriGene Antibodies for TMPO
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    Novus Biologicals TMPO Antibodies
    Abcam antibodies for TMPO (P42166, P42167)
    Cloud-Clone Corp. Antibodies for TMPO
    ThermoFisher Antibodies for TMPO
    LSBio Antibodies in human, mouse, rat for TMPO

    TMPO Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TMPO
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TMPO
    Cloud-Clone Corp. CLIAs for TMPO


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR021623 LAP2alpha
     IPR013146 LEM-like_dom
     IPR003887 LEM_dom
     IPR011015 LEM/LEM-like_dom

    Graphical View of Domain Structure for InterPro Entry P42166
    Graphical View of Domain Structure for InterPro Entry P42167

    ProtoNet protein and cluster: P42166

    2 Blocks protein domains:
    IPB003887 Lamino-associated polypeptide 2/emerin
    IPB011015 LEM-like fold


    UniProtKB/Swiss-Prot: LAP2A_HUMAN, P42166
    Domain: The N-terminal part contains two structurally independent, non-interacting domains: LEM-like (also called
    LAP2-N or LEM-D) and LEM (also called LAP2-C or LEM-B). LEM-like binds DNA while LEM interacts with BANF1
    Domain: The C-terminal domain forms a four-stranded coiled coil (By similarity)
    Similarity: Belongs to the LEM family
    Similarity: Contains 1 LEM domain
    Similarity: Contains 1 LEM-like domain

    UniProtKB/Swiss-Prot: LAP2B_HUMAN, P42167
    Domain: Has two structurally independent, non-interacting domains: LEM-like (also called LAP2-N or LEM-D) and LEM
    (also called LAP2-C or LEM-B). LEM-like binds DNA while LEM interacts with BANF1
    Similarity: Belongs to the LEM family
    Similarity: Contains 1 LEM domain
    Similarity: Contains 1 LEM-like domain


    TMPO for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:
    UniProtKB/Swiss-Prot Summary: LAP2A_HUMAN, P42166 (see all)
    Function: TP and TP5 may play a role in T-cell development and function. TP5 is an immunomodulating pentapeptide

         Genatlas biochemistry entry for TMPO:
    thymopoietin,nuclear precursor of subunits alpha (75kDa),beta (51kDa),gamma (39kDa),LAP2 (lamina-associated
    protein 2) family

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0005515protein binding IPI17474147
    GO:0005521lamin binding TAS8530026
         
    TMPO for ontologies           About GeneDecksing


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Tmpo):
     cellular  digestive/alimentary  endocrine/exocrine gland  hematopoietic system  integument 
     limbs/digits/tail 

    TMPO for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Tmpotm1.1Foi for TMPO

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TMPO
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TMPO

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TMPO
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TMPO

    miRNA
    Products:
        
    miRTarBase miRNAs that target TMPO:
    hsa-mir-106b-5p (MIRT044336), hsa-mir-192-5p (MIRT026410), hsa-mir-1296-5p (MIRT036084), hsa-mir-615-3p (MIRT039662), hsa-mir-1301-3p (MIRT035992), hsa-mir-320a (MIRT044781), hsa-mir-96-5p (MIRT048728), hsa-mir-215-5p (MIRT024489)

    Block miRNA regulation of human, mouse, rat TMPO using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TMPO (see all 49):
    hsa-miR-607 hsa-miR-1197 hsa-let-7d hsa-miR-139-5p hsa-miR-1245 hsa-miR-218 hsa-miR-550a* hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidTMPO 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TMPO
    Predesigned siRNA for gene silencing in human, mouse, rat TMPO

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TMPO

    Clone
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    OriGene clones in human, mouse for TMPO (see all 23)
    OriGene ORF clones in mouse, rat for TMPO
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): TMPO (NM_003276)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMPO
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMPO

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for TMPO 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMPO


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    LAP2A_HUMAN, P42166: Nucleus. Chromosome. Note=Expressed diffusely throughout the nucleus
    LAP2B_HUMAN, P42167: Nucleus inner membrane; Single-pass type II membrane protein. Note=Tightly associated with
    the nuclear lamina
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    extracellular1
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000785chromatin IDA17284516
    GO:0005634nucleus TAS8530026
    GO:0005635nuclear envelope TAS8530026
    GO:0005637nuclear inner membrane IEA--
    GO:0016021integral component of membrane IEA--

    TMPO for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TMPO About   (see all 9)  
    See pathways by source

    SuperPathContained pathways About
    1Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90
    2Nuclear Envelope Reassembly
    Nuclear Envelope Reassembly
    Initiation of Nuclear Envelope Reformation0.00
    Clearance of Nuclear Envelope Membranes from Chromatin0.00
    3Mitotic Metaphase and Anaphase
    Mitotic Anaphase0.94
    Mitotic Metaphase and Anaphase0.93
    4Regulation of Glucokinase by Glucokinase Regulatory Protein
    Nuclear Envelope Breakdown0.77
    5RNA Polymerase I Promoter Opening
    Mitotic Prophase0.56

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4 Cell Signaling Technology (CST) Pathways for TMPO
        Chromatin Regulation / Acetylation
    Apoptosis and Autophagy
    Cell Cycle / Checkpoint Control
    Cytoskeletal Signaling



    TMPO for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TMPO
    Interactions:

        GeneGlobe Interaction Network for TMPO

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TMPO (P421661, 2 P421671, 2, 3 ENSP000002667324) via UniProtKB, MINT, STRING, and/or I2D (see all 806)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LMNAP025452, ENSP000003572834MINT-7945693 MINT-7947479 STRING: ENSP00000357283
    SMARCAD1Q9H4L72, ENSP000003519474MINT-7945693 MINT-7947479 STRING: ENSP00000351947
    CDC5LQ994592, ENSP000003605324MINT-7945693 MINT-7947479 STRING: ENSP00000360532
    SMN1Q166372, ENSP000003700834MINT-7945693 MINT-7947479 STRING: ENSP00000370083
    SNW1Q135732, ENSP000002615314MINT-7945693 MINT-7947479 STRING: ENSP00000261531
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-templated IEA--

    TMPO for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TMPO (LAP2B)

    UniProtKB/Swiss-Prot: LAP2B_HUMAN, P42167
    Pharmaceutical: TP5 is available under the names Timunox (Cilag), Sintomodulina (Italofarmaco) and Mepentil
    (Recordati). Used in primary and secondary immune deficiencies, autoimmunity, infections and cancer

    Selected Novoseek inferred chemical compound relationships for TMPO gene (see all 34)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    thymopentin 99 258 8156337 (8), 7859140 (8), 2194133 (7), 1414149 (7) (see all 87)
    splenin 96.4 39 12035537 (4), 1780306 (3), 8209504 (3), 8296231 (2) (see all 15)
    thymotrinan 87.1 2 8959740 (1)
    sodium nucleinate 83 7 8296231 (2), 1810053 (1), 1409510 (1), 2395617 (1) (see all 5)
    vilozen 81.7 2 1475936 (1), 8209504 (1)
    cilag 74.3 3 2232966 (1), 1927119 (1), 1929608 (1)
    alpha-bungarotoxin 54.5 33 2005877 (6), 2089274 (5), 1463587 (5), 1848710 (5) (see all 6)
    cortisone 44.4 2 7566554 (1), 1545922 (1)
    phosphoramidon 39.1 2 9337153 (1), 9015192 (1)
    d-tubocurarine 37.2 7 16952408 (1), 2005877 (1), 1848710 (1)



    TMPO for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TMPO gene (3 alternative transcripts): 
    NM_001032283.2  NM_001032284.2  NM_003276.2  

    Unigene Cluster for TMPO:

    Thymopoietin
    Hs.11355  [show with all ESTs]
    Unigene Representative Sequence: NM_001032283
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000556029(uc001tfi.2 uc001tfl.3 uc001tfj.3 uc001tfk.3)
    ENST00000548911 ENST00000343315 ENST00000266732(uc001tfh.2) ENST00000393053
    ENST00000546828 ENST00000261210 ENST00000549938 ENST00000552831 ENST00000547214
    ENST00000556678 ENST00000548223 ENST00000551987
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate TMPO (see all 49):
    hsa-miR-607 hsa-miR-1197 hsa-let-7d hsa-miR-139-5p hsa-miR-1245 hsa-miR-218 hsa-miR-550a* hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidTMPO 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TMPO
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): TMPO (NM_003276)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMPO
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMPO
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for TMPO
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TMPO
      QuantiTect SYBR Green Assays in human, mouse, rat TMPO
      QuantiFast Probe-based Assays in human, mouse, rat TMPO

    Additional mRNA sequence: 

    AB209297.1 AF070631.1 AF113682.1 AJ293393.1 AK299708.1 AK315221.1 BC050383.2 BC053675.1 
    EF028063.1 S76736.1 U09086.1 U09087.1 U09088.1 

    Selected DOTS entries (see all 25):

    DT.100796507  DT.100796503  DT.100030556  DT.100796501  DT.100746218  DT.100796511  DT.97780484  DT.311599 
    DT.70105209  DT.92021605  DT.101961568  DT.100796516  DT.86855420  DT.95271354  DT.100796498  DT.100809419 
    DT.121209690  DT.121209719  DT.91768298  DT.95271355  DT.100030563  DT.100796500  DT.100796514  DT.102832894 

    Selected AceView cDNA sequences (see all 429):

    AW272611 AA962016 AA576922 H88320 BM463746 AW576240 CA436743 AA827221 
    AI610537 BQ420376 AW021765 BU182940 BQ016146 CN480680 BM263980 AA961939 
    S76736 AA253403 AI160828 BF195606 CA414492 AI823994 AU142415 AI369160 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for TMPO    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b
    SP1:              -           -                 -                           
    SP2:              -           -     -     -     -     -                     
    SP3:                                            -                           
    SP4:                                                                        
    SP5:                                                                        


    ECgene alternative splicing isoforms for TMPO

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    TMPO expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACTTGGTCT
    TMPO Expression
    About this image


    TMPO expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Brain (Nervous System)    fully expand to see all 7 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Thymus (Hematopoietic System)    fully expand to see all 2 entries
             Double Negative 2 Thymocytes Thymus
             Thymus
     
     Bone (Muscoskeletal System)
             Bone Marrow
    TMPO Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TMPO Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.11355

    UniProtKB/Swiss-Prot: LAP2A_HUMAN, P42166
    Tissue specificity: Expressed in many tissues. Most abundant in adult thymus and fetal liver

    UniProtKB/Swiss-Prot: LAP2B_HUMAN, P42167
    Tissue specificity: Expressed in many tissues. Most abundant in adult thymus and fetal liver

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TMPO gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tmpo1 , 5 thymopoietin1, 5 89.75(n)1
    91.15(a)1
      10 (45.66 cM)5
    219171  NM_001080129.21  NP_001073598.11 
     911475715 
    chicken
    (Gallus gallus)
    Aves TMPO1 thymopoietin 80.26(n)
    76.5(a)
      417923  NM_001006235.1  NP_001006235.1 
    lizard
    (Anolis carolinensis)
    Reptilia TMPO6
    thymopoietin
    37(a)
    1 ↔ 1
    5(29343116-29363871)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.4642 Xenopus laevis clone 2 lamina associated protein 2-beta more 78.87(n)    AF048815.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tmpo2 thymopoietin 71.97(n)   352907  AJ320189.1 


    ENSEMBL Gene Tree for TMPO (if available)
    TreeFam Gene Tree for TMPO (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TMPO gene

    TMPO for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for TMPO
    PGOHUM00000249173 PGOHUM00000243574


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TMPO (see all 894)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs170284501,2,,4
    C,F,HCardiomyopathy, dilated 1T (CMD1T)4 pathogenic198767183(+) AAAAGC/TGTGGA 4 R C mis1 int113Minor allele frequency- T:0.00NA NS EA EU 5785
    rs359981381,2,,4
    C,Fprobable-non-pathogenic198765828(+) CGAACT/GACAGG 4 /R /L mis1 int16Minor allele frequency- G:0.02NA CSA WA 4738
    rs356452871,2,,4
    C,Fprobable-non-pathogenic198765992(+) GTTCTT/GCGTCA 4 /A /S mis1 int16Minor allele frequency- G:0.02NA CSA WA 4740
    rs359692211,2,,4
    C,Fprobable-non-pathogenic198766065(+) AGAAAC/GCACCA 4 T S mis1 int16Minor allele frequency- G:0.04NA CSA WA 4606
    rs357610891,2,,4
    C,Fprobable-non-pathogenic198766549(+) GCTAAG/CCAATC 4 /N /K mis1 int16Minor allele frequency- C:0.02NA CSA WA 4750
    rs14397751,2
    C,F,H--98746465(-) CATCTC/GCAACA 3 -- us2k17Minor allele frequency- G:0.05NS EA WA 708
    rs1832409931,2
    --98746577(+) ACCTAC/TGGCAA 3 -- us2k10--------
    rs1440722461,2
    C--98746687(+) TTTTGA/CAGCAG 3 -- us2k10--------
    rs796306801,2
    C,F--98746699(+) AAAGAG/CCAGAA 3 -- us2k12Minor allele frequency- C:0.04CSA WA 120
    rs1444098301,2
    --98746772(+) GCCTTA/GGGGTA 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for TMPO (98909290 - 98944157 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for TMPO:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2601754CNV Deletion19546169
    nsv7234OTHER Inversion18451855

    Human Gene Mutation Database (HGMD): TMPO
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TMPO
    DNA2.0 Custom Variant and Variant Library Synthesis for TMPO

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 188380   
    OMIM disorders: 613740  
    UniProtKB/Swiss-Prot: LAP2B_HUMAN, P42167
  • Cardiomyopathy, dilated 1T (CMD1T) [MIM:613740]: A disorder characterized by ventricular dilation and
    impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of
    premature death. Note=The disease is caused by mutations affecting the gene represented in this entry

  • Selected diseases for TMPO (see all 71):    
    About MalaCards
    cardiomyopathy, dilated, 1t    phobic disorder    tmpo-related dilated cardiomyopathy    alopecia totalis
    nezelof syndrome    dysentery    herpes zoster    bronchitis
    cardiomyopathy, dilated, 1w    acrodermatitis    acrodermatitis enteropathica    enteropathica
    lymphocytic choriomeningitis    oral candidiasis    leukopenia    dilated cardiomyopathy
    viral hepatitis    myasthenia gravis    alopecia    neuromuscular disease

    2 diseases from the University of Copenhagen DISEASES database for TMPO:
    Myasthenia gravis     Nezelof syndrome

    TMPO for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

    Selected Novoseek inferred disease relationships for TMPO gene (see all 47)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    muscular dystrophy emery-dreifuss 74.5 1 10806084 (1)
    bronchitis chronic 40.2 7 2236822 (2), 1306635 (1), 1845435 (1), 2140311 (1) (see all 5)
    postoperative infection 35.4 6 8156337 (4), 8776187 (1), 1565267 (1)
    aids-related complex 35.1 1 7859140 (1)
    dermatitis atopic 30.4 11 8157786 (4), 11145854 (3), 1329673 (2), 2185294 (2)
    myasthenia gravis 30.3 7 20193562 (2), 8332357 (1), 19087694 (1), 17131816 (1)
    sclerosis systemic 20 3 7882698 (2), 1828204 (1)
    leukopenia 16.7 2 2255416 (1), 7516641 (1)
    phobias 15.5 3 2092042 (2)
    arthritis juvenile rheumatoid 12.9 4 1971780 (2), 1376077 (1)

    Genetic Association Database (GAD): TMPO
    Human Genome Epidemiology (HuGE) Navigator: TMPO (5 documents)

    Export disorders for TMPO gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TMPO gene, integrated from 10 sources (see all 301):
    (articles sorted by number of sources associating them with TMPO)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Three distinct human thymopoietins are derived from alternatively spliced mRNAs. (PubMed id 7517549)1, 2, 3, 9 Harris C.A.... Goldstein G. (Proc. Natl. Acad. Sci. U.S.A. 1994)
    2. Structure and mapping of the human thymopoietin (TMPO) gene and relationship of human TMPO beta to rat lamin-associated polypeptide 2. (PubMed id 8530026)1, 2, 9 Harris C.A.... Goldstein G. (Genomics 1995)
    3. Review: lamina-associated polypeptide 2 isoforms and related proteins in cell cycle-dependent nuclear structure dynamics. (PubMed id 10806084)1, 2, 9 Dechat T.... Foisner R. (J. Struct. Biol. 2000)
    4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    5. Genome-wide SNP genotyping study using pooled DNA to identify candidate markers mediating susceptibility to end-stage renal disease attributed to Type 1 diabetes. (PubMed id 19929986)1, 4 Craig D.W....DiStefano J.K. (Diabet. Med. 2009)
    6. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. HA95 and LAP2 beta mediate a novel chromatin-nuclear envelope interaction implicated in initiation of DNA replication. (PubMed id 12538639)1, 2 Martins S.... Collas P. (J. Cell Biol. 2003)
    9. Structural characterization of the LEM motif common to three human inner nuclear membrane proteins. (PubMed id 11435115)1, 2 Laguri C.... Zinn-Justin S. (Structure 2001)
    10. Solution structure of the constant region of nuclear envelope protein LAP2 reveals two LEM-domain structures: one binds BAF and the other binds DNA. (PubMed id 11500367)1, 2 Cai M.... Clore G.M. (EMBO J. 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7112 HGNC: 11875 AceView: TMPO Ensembl:ENSG00000120802 euGenes: HUgn7112
    ECgene: TMPO H-InvDB: TMPO

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TMPO Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TMPO gene:
    Search GeneIP for patents involving TMPO

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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