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Aliases for TMPO Gene

Aliases for TMPO Gene

  • Thymopoietin 2 3 3 5
  • Thymopoietin-Related Peptide Isoforms Beta/Gamma 3 4
  • Thymopoietin-Related Peptide Isoform Alpha 3 4
  • LEM Domain Containing 4 2 3
  • TP Beta/Gamma 3 4
  • TP Alpha 3 4
  • LAP2 3 4
  • Thymopoietin, Isoforms Beta/Gamma 4
  • Lamina-Associated Polypeptide 2 3
  • Thymopoietin Isoform Alpha 4
  • TPRP Isoforms Beta/Gamma 4
  • TPRP Isoform Alpha 4
  • Thymopoietin Beta 3
  • PRO0868 3
  • CMD1T 3
  • LEMD4 3
  • TP 3

External Ids for TMPO Gene

Previous GeneCards Identifiers for TMPO Gene

  • GC12M098312
  • GC12P099412
  • GC12P098842
  • GC12P097411
  • GC12P098909
  • GC12P095970

Summaries for TMPO Gene

Entrez Gene Summary for TMPO Gene

  • The protein encoded by this gene resides in the nucleus and may play a role in the assembly of the nuclear lamina, and thus help maintain the structural organization of the nuclear envelope. It may function as a receptor for the attachment of lamin filaments to the inner nuclear membrane. Mutations in this gene are associated with dilated cardiomyopathy. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, May 2010]

GeneCards Summary for TMPO Gene

TMPO (Thymopoietin) is a Protein Coding gene. Diseases associated with TMPO include Cardiomyopathy, Dilated, 1T and Tmpo-Related Dilated Cardiomyopathy. Among its related pathways are Nuclear Envelope Reassembly and Apoptosis and Autophagy. GO annotations related to this gene include lamin binding.

UniProtKB/Swiss-Prot for TMPO Gene

  • May be involved in the structural organization of the nucleus and in the post-mitotic nuclear assembly. Plays an important role, together with LMNA, in the nuclear anchorage of RB1.

  • TP and TP5 may play a role in T-cell development and function. TP5 is an immunomodulating pentapeptide.

  • May help direct the assembly of the nuclear lamina and thereby help maintain the structural organization of the nuclear envelope. Possible receptor for attachment of lamin filaments to the inner nuclear membrane. May be involved in the control of initiation of DNA replication through its interaction with NAKAP95.

  • Thymopoietin (TP) and Thymopentin (TP5) may play a role in T-cell development and function. TP5 is an immunomodulating pentapeptide.

Gene Wiki entry for TMPO Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMPO Gene

Genomics for TMPO Gene

Regulatory Elements for TMPO Gene

Enhancers for TMPO Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G098512 1.7 Ensembl ENCODE dbSUPER 27.5 +0.6 608 7.0 FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 ZNF610 GLIS1 TMPO RNU4-41P SLC9A7P1 TMPO-AS1 LINC02453 GC12M098515
GH12G098502 1.4 ENCODE dbSUPER 26.8 -11.6 -11615 2.9 CREB3L1 ZFP64 DMAP1 YY1 SP3 TBX21 ZNF610 RCOR2 NBN NR2C1 TMPO SLC9A7P1 SLC25A3 TRW-CCA4-1 LINC02453
GH12G098490 1.8 VISTA Ensembl ENCODE dbSUPER 17.1 -23.9 -23944 4.2 HDGF MLX ARNT ZNF133 WRNIP1 ARID4B SIN3A DMAP1 YY1 ZNF143 TMPO RNU4-41P SLC9A7P1 GC12P098497 GC12M098479
GH12G098592 1.1 ENCODE 23.4 +79.0 79004 4.3 PKNOX1 CREB3L1 ARNT AGO1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 TMPO SLC25A3 IKBIP APAF1 GC12M098595
GH12G098424 1.3 FANTOM5 Ensembl ENCODE 11.3 -90.5 -90508 1.2 GTF2F1 CTCF TEAD4 ZNF2 RAD21 RFX5 TEAD3 SCRT2 ZNF143 SMC3 LINC02453 TMPO SLC9A7P1 GC12M098419 RNU4-41P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMPO on UCSC Golden Path with GeneCards custom track

Promoters for TMPO Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000056128 788 4201 FEZF1 DMAP1 YY1 ZNF143 SP3 NFYC TBX21 ZNF610 GLIS1 NBN

Genomic Location for TMPO Gene

Chromosome:
12
Start:
98,515,512 bp from pter
End:
98,550,379 bp from pter
Size:
34,868 bases
Orientation:
Plus strand

Genomic View for TMPO Gene

Genes around TMPO on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMPO Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMPO Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMPO Gene

Proteins for TMPO Gene

  • Protein details for TMPO Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P42166-LAP2A_HUMAN
    Recommended name:
    Lamina-associated polypeptide 2, isoform alpha
    Protein Accession:
    P42166
    Secondary Accessions:
    • P08918
    • P08919
    • Q14860
    • Q16295

    Protein attributes for TMPO Gene

    Size:
    694 amino acids
    Molecular mass:
    75492 Da
    Quaternary structure:
    • Interacts with LMNA, BANF1 and RB1 and with chromosomes. Associates directly or indirectly with lamins at specific cell-cycle stages.

    Three dimensional structures from OCA and Proteopedia for TMPO Gene

    Alternative splice isoforms for TMPO Gene

    UniProtKB/Swiss-Prot:
  • Protein details for TMPO Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P42167-LAP2B_HUMAN
    Recommended name:
    Lamina-associated polypeptide 2, isoforms beta/gamma
    Protein Accession:
    P42167
    Secondary Accessions:
    • A2T926
    • Q14861

    Protein attributes for TMPO Gene

    Size:
    454 amino acids
    Molecular mass:
    50670 Da
    Quaternary structure:
    • Interacts with LMNB1, LMNB2, BANF1, AKAP8L, GMCL and chromosomes (By similarity). Isoform Zeta interacts with BANF1/BAF and may sequester it in the cytoplasm.

    Alternative splice isoforms for TMPO Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMPO Gene

Post-translational modifications for TMPO Gene

  • Phosphorylated in a mitose-specific manner.
  • Citrullinated by PADI4.
  • Mitosis-specific phosphorylation specifically abolishes its binding to lamin B and chromosomes.
  • Ubiquitination at Lys213, Lys346, isoforms=2389, Lys393, and Lys401
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for TMPO (TMPO iso6)
  • Santa Cruz Biotechnology (SCBT) Antibodies for TMPO

No data available for DME Specific Peptides for TMPO Gene

Domains & Families for TMPO Gene

Gene Families for TMPO Gene

Graphical View of Domain Structure for InterPro Entry

P42166

UniProtKB/Swiss-Prot:

LAP2B_HUMAN :
  • The N-terminal part contains two structurally independent, non-interacting domains: LEM-like (also called LAP2-N or LEM-D) and LEM (also called LAP2-C or LEM-B). LEM-like binds DNA while LEM interacts with BANF1.
  • Belongs to the LEM family.
Domain:
  • The N-terminal part contains two structurally independent, non-interacting domains: LEM-like (also called LAP2-N or LEM-D) and LEM (also called LAP2-C or LEM-B). LEM-like binds DNA while LEM interacts with BANF1.
  • The C-terminal domain forms a four-stranded coiled coil.
  • Has two structurally independent, non-interacting domains: LEM-like (also called LAP2-N or LEM-D) and LEM (also called LAP2-C or LEM-B). LEM-like binds DNA while LEM interacts with BANF1.
Family:
  • Belongs to the LEM family.
genes like me logo Genes that share domains with TMPO: view

Function for TMPO Gene

Molecular function for TMPO Gene

GENATLAS Biochemistry:
thymopoietin,nuclear precursor of subunits alpha (75kDa),beta (51kDa),gamma (39kDa),LAP2 (lamina-associated protein 2) family
UniProtKB/Swiss-Prot Function:
May be involved in the structural organization of the nucleus and in the post-mitotic nuclear assembly. Plays an important role, together with LMNA, in the nuclear anchorage of RB1.
UniProtKB/Swiss-Prot Function:
TP and TP5 may play a role in T-cell development and function. TP5 is an immunomodulating pentapeptide.
UniProtKB/Swiss-Prot Function:
May help direct the assembly of the nuclear lamina and thereby help maintain the structural organization of the nuclear envelope. Possible receptor for attachment of lamin filaments to the inner nuclear membrane. May be involved in the control of initiation of DNA replication through its interaction with NAKAP95.
UniProtKB/Swiss-Prot Function:
Thymopoietin (TP) and Thymopentin (TP5) may play a role in T-cell development and function. TP5 is an immunomodulating pentapeptide.

Gene Ontology (GO) - Molecular Function for TMPO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI --
GO:0005521 lamin binding TAS 8530026
GO:0045296 cadherin binding IDA 25468996
genes like me logo Genes that share ontologies with TMPO: view
genes like me logo Genes that share phenotypes with TMPO: view

Human Phenotype Ontology for TMPO Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for TMPO Gene

MGI Knock Outs for TMPO:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for TMPO
  • Applied Biological Materials Clones for TMPO

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for TMPO Gene

Localization for TMPO Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMPO Gene

Nucleus. Chromosome. Note=Expressed diffusely throughout the nucleus.
Nucleus inner membrane; Single-pass type II membrane protein. Note=Tightly associated with the nuclear lamina.
Isoform Zeta: Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMPO gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for TMPO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 chromatin IDA 17284516
GO:0005634 nucleus IDA,TAS 17284516
GO:0005635 nuclear envelope IEA,TAS --
GO:0005637 nuclear inner membrane IEA --
GO:0005694 chromosome IEA --
genes like me logo Genes that share ontologies with TMPO: view

Pathways & Interactions for TMPO Gene

genes like me logo Genes that share pathways with TMPO: view

Gene Ontology (GO) - Biological Process for TMPO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with TMPO: view

No data available for SIGNOR curated interactions for TMPO Gene

Drugs & Compounds for TMPO Gene

(18) Drugs for TMPO Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(16) Additional Compounds for TMPO Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TMPO: view

Transcripts for TMPO Gene

Unigene Clusters for TMPO Gene

Thymopoietin:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for TMPO
  • Applied Biological Materials Clones for TMPO

Alternative Splicing Database (ASD) splice patterns (SP) for TMPO Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b
SP1: - - -
SP2: - - - - - -
SP3: -
SP4:
SP5:

Relevant External Links for TMPO Gene

GeneLoc Exon Structure for
TMPO
ECgene alternative splicing isoforms for
TMPO

Expression for TMPO Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMPO Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TMPO Gene



Protein tissue co-expression partners for TMPO Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TMPO Gene:

TMPO

SOURCE GeneReport for Unigene cluster for TMPO Gene:

Hs.11355

mRNA Expression by UniProt/SwissProt for TMPO Gene:

P42166-LAP2A_HUMAN
Tissue specificity: Expressed in many tissues. Most abundant in adult thymus and fetal liver.

Evidence on tissue expression from TISSUES for TMPO Gene

  • Nervous system(4.8)
  • Blood(4.4)
  • Eye(4.3)
  • Liver(4.3)
  • Spleen(2.7)
  • Bone marrow(2.5)

Phenotype-based relationships between genes and organs from Gene ORGANizer for TMPO Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • nervous
  • respiratory
  • skeletal muscle
Organs:
Head and neck:
  • brain
  • ear
  • head
Thorax:
  • heart
  • heart valve
  • lung
Limb:
  • lower limb
  • upper limb
General:
  • blood
  • blood vessel
  • coagulation system
  • red blood cell
  • spinal cord
genes like me logo Genes that share expression patterns with TMPO: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein differential expression in normal tissues for TMPO Gene

Orthologs for TMPO Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMPO Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMPO 34 35
  • 99.71 (n)
dog
(Canis familiaris)
Mammalia TMPO 34 35
  • 94.78 (n)
mouse
(Mus musculus)
Mammalia Tmpo 34 16 35
  • 89.75 (n)
rat
(Rattus norvegicus)
Mammalia Tmpo 34
  • 89.75 (n)
cow
(Bos Taurus)
Mammalia TMPO 34 35
  • 75.45 (n)
oppossum
(Monodelphis domestica)
Mammalia TMPO 35
  • 42 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMPO 35
  • 38 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMPO 34 35
  • 80.26 (n)
lizard
(Anolis carolinensis)
Reptilia TMPO 35
  • 37 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmpo 34
  • 69.58 (n)
MGC75950 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.464 34
zebrafish
(Danio rerio)
Actinopterygii tmpoa 34 35
  • 59.21 (n)
tmpob 35
  • 30 (a)
OneToMany
TMPO (3 of 3) 35
  • 28 (a)
OneToMany
tmpo 34
Species where no ortholog for TMPO was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMPO Gene

ENSEMBL:
Gene Tree for TMPO (if available)
TreeFam:
Gene Tree for TMPO (if available)

Paralogs for TMPO Gene

genes like me logo Genes that share paralogs with TMPO: view

No data available for Paralogs for TMPO Gene

Variants for TMPO Gene

Sequence variations from dbSNP and Humsavar for TMPO Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1058300 Likely benign 98,547,859(+) ACTGA(A/G)TGGTA utr-variant-3-prime
rs11109520 Likely benign 98,534,868(+) ATCAT(A/G)GTAGT intron-variant, utr-variant-3-prime
rs114939776 Likely benign 98,533,182(+) CTGCA(C/G)CTTCT intron-variant, reference, missense
rs11838270 Likely benign 98,533,503(+) AGTCT(A/G)AGTTT intron-variant, reference, missense
rs12316677 Likely benign 98,533,889(+) TTTAT(A/T)TCTGA intron-variant, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for TMPO Gene

Variant ID Type Subtype PubMed ID
esv2601754 CNV deletion 19546169
esv2761763 CNV loss 21179565
nsv1040329 CNV gain 25217958
nsv1138163 CNV deletion 24896259
nsv7234 OTHER inversion 18451855
nsv975655 CNV duplication 23825009

Variation tolerance for TMPO Gene

Residual Variation Intolerance Score: 63.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.64; 78.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMPO Gene

Human Gene Mutation Database (HGMD)
TMPO
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMPO

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMPO Gene

Disorders for TMPO Gene

MalaCards: The human disease database

(14) MalaCards diseases for TMPO Gene - From: OMIM, GeneTests, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
cardiomyopathy, dilated, 1t
  • dilated cardiomyopathy 1t
tmpo-related dilated cardiomyopathy
  • dilated cardiomyopathy 1t
familial isolated dilated cardiomyopathy
  • familial or idiopathic dilated cardiomyopathy
alopecia totalis
  • loss of all scalp hair
dysentery
  • infectious diarrhea
- elite association - COSMIC cancer census association via MalaCards
Search TMPO in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

LAP2B_HUMAN
  • Cardiomyopathy, dilated 1T (CMD1T) [MIM:613740]: A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. {ECO:0000269 PubMed:16247757}. Note=The disease may be caused by mutations affecting the gene represented in this entry.

Relevant External Links for TMPO

Genetic Association Database (GAD)
TMPO
Human Genome Epidemiology (HuGE) Navigator
TMPO
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMPO
genes like me logo Genes that share disorders with TMPO: view

No data available for Genatlas for TMPO Gene

Publications for TMPO Gene

  1. Three distinct human thymopoietins are derived from alternatively spliced mRNAs. (PMID: 7517549) Harris C.A. … Goldstein G. (Proc. Natl. Acad. Sci. U.S.A. 1994) 2 3 4 22 64
  2. Structure and mapping of the human thymopoietin (TMPO) gene and relationship of human TMPO beta to rat lamin-associated polypeptide 2. (PMID: 8530026) Harris C.A. … Goldstein G. (Genomics 1995) 3 4 22 64
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  4. Genome-wide SNP genotyping study using pooled DNA to identify candidate markers mediating susceptibility to end-stage renal disease attributed to Type 1 diabetes. (PMID: 19929986) Craig D.W. … DiStefano J.K. (Diabet. Med. 2009) 3 46 64
  5. LAP2zeta binds BAF and suppresses LAP2beta-mediated transcriptional repression. (PMID: 18403046) Shaklai S. … Rechavi G. (Eur. J. Cell Biol. 2008) 3 4 64

Products for TMPO Gene

  • Addgene plasmids for TMPO

Sources for TMPO Gene

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