TMPO Gene
protein-coding GIFtS: 59
GCID: GC12P098909
|
|
thymopoietin
| |
Aliases
for TMPO gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Thymopoietin1 | | CMD1T2 5 | | LAP21 2 3 5 | | PRO08682 | | LEMD41 2 | | Lamina-Associated Polypeptide 22 | | TP1 2 | | LEM Domain Containing 42 | | Thymopoietin-Related Peptide Isoform Alpha2 3 | | Thymopoietin Isoform Alpha3 | | Thymopoietin-Related Peptide Isoforms Beta/Gamma2 3 | | Thymopoietin, Isoforms Beta/Gamma3 | | TP Alpha2 3 | | TPRP Isoform Alpha3 | | TP Beta/Gamma2 3 | | TPRP Isoforms Beta/Gamma3 |
Export aliases for TMPO gene to outside databasesPrevious GC identifers: GC12M098312 GC12P099412 GC12P098842 GC12P097411 GC12P095970 |
Summaries
for TMPO gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TMPO:
The protein encoded by this gene resides in the nucleus and may play a role in the assembly of the nuclear lamina, andthus help maintain the structural organization of the nuclear envelope. It may function as a receptor for theattachment of lamin filaments to the inner nuclear membrane. Mutations in this gene are associated with dilatedcardiomyopathy. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.(provided by RefSeq, May 2010)
UniProtKB/Swiss-Prot: LAP2B_HUMAN, P42167Function: May help direct the assembly of the nuclear lamina and thereby help maintain the structural organization ofthe nuclear envelope. Possible receptor for attachment of lamin filaments to the inner nuclear membrane. May beinvolved in the control of initiation of DNA replication through its interaction with NAKAP95Function: TP and TP5 may play a role in T-cell development and function. TP5 is an immunomodulating pentapeptide
Gene Wiki entry for TMPO (Thymopoietin)
|
Genomic Views
for TMPO gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_029419.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TMPO gene promoter:
HEN1 SRY Pax-5 AP-4 GATA-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for TMPO
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMPO |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q22 Ensembl cytogenetic band: 12q23.1 HGNC cytogenetic band: 12q22TMPO Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12P098909: view genomic region
(about GC identifiers)
Start:
|
98,909,290 bp from pter |
End:
|
98,944,157 bp from pter |
Size:
|
34,868 bases |
Orientation:
|
plus strand |
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Proteins
for TMPO gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: LAP2A_HUMAN, P42166 (See
protein sequence)Recommended Name: Lamina-associated polypeptide 2, isoform alpha Size: 694 amino acids; 75492 Da
Subunit: Interacts with LMNA, BANF1 and RB1 and with chromosomes. Associates directly or indirectly with lamins atspecific cell-cycle stages
Subcellular location: Nucleus. Chromosome. Note=Expressed diffusely throughout the nucleus
3 PDB 3D structures from  and Proteopedia  for TMPO:1GJJ (3D)
1H9E (3D)
1H9F (3D)
Secondary accessions: P08918 P08919 Q14860 Q16295Alternative splicing: 3 isoforms: P42166-1 P42167-1 P42167-2 UniProtKB/Swiss-Prot: LAP2B_HUMAN, P42167 (See
protein sequence) Recommended Name: Lamina-associated polypeptide 2, isoforms beta/gamma Size: 454 amino acids; 50670 Da
Subunit: Interacts with LMNB1, LMNB2, BANF1, AKAP8L, GMCL and chromosomes (By similarity)
Subcellular location: Nucleus inner membrane; Single-pass type II membrane protein. Note=Tightly associated with thenuclear lamina
Secondary accessions: Q14861Alternative splicing: 3 isoforms: P42167-1 P42166-1 P42167-2 Explore the universe of human proteins at neXtProt for TMPO: NX_P42167
Post-translational modifications:
Phosphorylated in a mitose-specific manner1
Mitosis-specific phosphorylation specifically abolishes its binding to lamin B and chromosomes (By similarity)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P42167
TMPO Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001027454.1 NP_001027455.1 NP_003267.1
ENSEMBL proteins: ENSP00000450627 ENSP00000340251 ENSP00000266732 ENSP00000376773 ENSP00000261210 ENSP00000451552 Reactome Protein details: P42167
Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
TMPO for ontologies About GeneDecksing
TMPO Antibody Products:
Assay Products for TMPO: |
Protein
Domains /
Families
for TMPO gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TMPO for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P42166Graphical View of Domain Structure for InterPro Entry P42167ProtoNet protein and cluster: P42166 2 Blocks protein families: IPB003887 Lamino-associated polypeptide 2/emerin IPB011015 LEM-like fold
UniProtKB/Swiss-Prot: LAP2A_HUMAN, P42166Domain: The N-terminal part contains two structurally independent, non-interacting domains: LEM-like (also calledLAP2-N or LEM-D) and LEM (also called LAP2-C or LEM-B). LEM-like binds DNA while LEM interacts with BANF1Domain: The C-terminal domain forms a four-stranded coiled coil (By similarity)Similarity: Belongs to the LEM familySimilarity: Contains 1 LEM domainSimilarity: Contains 1 LEM-like domainUniProtKB/Swiss-Prot: LAP2B_HUMAN, P42167Domain: Has two structurally independent, non-interacting domains: LEM-like (also called LAP2-N or LEM-D) and LEM (alsocalled LAP2-C or LEM-B). LEM-like binds DNA while LEM interacts with BANF1Similarity: Belongs to the LEM familySimilarity: Contains 1 LEM domainSimilarity: Contains 1 LEM-like domain |
Function
for TMPO gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/ace: LAP2A_HUMAN, P42166 (see all)Function: TP and TP5 may play a role in T-cell development and function. TP5 is an immunomodulating pentapeptide Genatlas biochemistry entry for TMPO:thymopoietin,nuclear precursor of subunits alpha (75kDa),beta (51kDa),gamma (39kDa),LAP2 (lamina-associated protein 2)family
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMPO (see all 10)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMPO (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): TMPO (NM_003276) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMPO | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMPO |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMPO |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
TMPO for ontologies About GeneDecksing
Animal Models:
Mouse knock-out Tmpotm1.1Foi for TMPO
6 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Tmpo):
TMPO for phenotypes About GeneDecksing
|
Pathways & Interactions
for TMPO gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Clearance of Nuclear Envelope Membranes from Chromatin | | | 2 | M Phase | | | 3 | Cell Cycle | | | 4 | Cytoskeletal Signaling | | | 5 | Cell Cycle / Checkpoint Control | |
Pathway sources
See GeneCards unified pathways
Show all pathways
4 
Cell Signaling Technology (CST) Pathways for TMPO
5/11 
Reactome Pathways for TMPO (see all 11)
TMPO for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TMPO
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/769 Interacting proteins for TMPO (P421661, 2 P421671, 2, 3 ENSP000002667324) via UniProtKB, MINT, STRING, and/or I2D (see all 769)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
TMPO for ontologies About GeneDecksing
|
Drugs & Compounds
for TMPO gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
TMPO for compounds About GeneDecksing
 Browse Tocris compounds for TMPO
UniProtKB/Swiss-Prot: LAP2B_HUMAN, P42167Pharmaceutical: TP5 is available under the names Timunox (Cilag), Sintomodulina (Italofarmaco) and Mepentil(Recordati). Used in primary and secondary immune deficiencies, autoimmunity, infections and cancer
10/34 Novoseek chemical compound relationships for TMPO gene (see all 34) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| thymopentin |
99 |
258 |
8156337 (8), 7859140 (8), 2194133 (7), 1414149 (7) (see all 87) |
| splenin |
96.4 |
39 |
12035537 (4), 1780306 (3), 8209504 (3), 8296231 (2) (see all 15) |
| thymotrinan |
87.1 |
2 |
8959740 (1) |
| sodium nucleinate |
83 |
7 |
8296231 (2), 1810053 (1), 1409510 (1), 2395617 (1) (see all 5) |
| vilozen |
81.7 |
2 |
1475936 (1), 8209504 (1) |
| cilag |
74.3 |
3 |
2232966 (1), 1927119 (1), 1929608 (1) |
| alpha-bungarotoxin |
54.5 |
33 |
2005877 (6), 2089274 (5), 1463587 (5), 1848710 (5) (see all 6) |
| cortisone |
44.4 |
2 |
7566554 (1), 1545922 (1) |
| phosphoramidon |
39.1 |
2 |
9337153 (1), 9015192 (1) |
| d-tubocurarine |
37.2 |
7 |
16952408 (1), 2005877 (1), 1848710 (1) |
Search CenterWatch for drugs/clinical trials and news about TMPO / LAP2B
|
Transcripts
for TMPO gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TMPO gene (3 alternative transcripts): NM_001032283.2 NM_001032284.2 NM_003276.2 Unigene Cluster for TMPO: Thymopoietin Hs.11355 [show with all ESTs]Unigene Representative Sequence: NM_00103228313 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000556029(uc001tfi.2 uc001tfl.3 uc001tfj.3 uc001tfk.3)
ENST00000548911 ENST00000343315 ENST00000266732(uc001tfh.2) ENST00000393053
ENST00000546828 ENST00000261210 ENST00000549938 ENST00000552831 ENST00000547214
ENST00000556678 ENST00000548223 ENST00000551987
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMPO (see all 10)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMPO (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): TMPO (NM_003276) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMPO | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMPO |
Additional cDNA sequence: AB209297.1 AF070631.1 AF113682.1 AJ293393.1 AK299708.1 AK315221.1 BC050383.2 BC053675.1 EF028063.1 S76736.1 U09086.1 U09087.1 U09088.1 24/25 DOTS entries (see all 25): DT.100796507 DT.100796503 DT.100030556 DT.100796501 DT.100746218 DT.100796511 DT.97780484 DT.311599 DT.70105209 DT.92021605 DT.101961568 DT.100796516 DT.86855420 DT.95271354 DT.100796498 DT.100809419 DT.121209690 DT.121209719 DT.91768298 DT.95271355 DT.100030563 DT.100796500 DT.100796514 DT.102832894 24/429 AceView cDNA sequences (see all 429): AI078793 AA334012 AW576472 AA045266 AI289097 BX105050 BF195606 NM_003276 AL535740 BQ420376 AL597131 CB151427 CA414492 CA436743 CB129849 AA505644 BF438651 S76736 BM726296 H87991 AI205642 BM969041 BU682773 BU191826
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for TMPO About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b |
|---|
|
| SP1: | | | | | - | | | | - | | | | | | - | | | | | | | | | | |
| SP2: | | | | | - | | | | - | | - | | - | | - | | - | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | - | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for TMPO
|
Expression
for TMPO gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TMPO expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TACTTGGTCT
About this image
See TMPO Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TMPO
SOURCE GeneReport for Unigene cluster: Hs.11355
UniProtKB/Swiss-Prot: LAP2A_HUMAN, P42166Tissue specificity: Expressed in many tissues. Most abundant in adult thymus and fetal liver
UniProtKB/Swiss-Prot: LAP2B_HUMAN, P42167Tissue specificity: Expressed in many tissues. Most abundant in adult thymus and fetal liver
SABiosciences Custom PCR Arrays for TMPO
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMPO
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TMPO | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMPO | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMPO | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMPO |
Orthologs
for TMPO gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for TMPO gene from 6/14 species (see all 14) About this table
ENSEMBL Gene Tree for TMPO (if available)
TreeFam Gene Tree for TMPO (if available) |
Paralogs
for TMPO gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TMPO gene
TMPO for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for TMPO
PGOHUM00000249173 PGOHUM00000243574
|
Genomic Variants
for TMPO gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TMPO (98909290 - 98944157 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for TMPO
1 CNV: 101600
Human Gene Mutation Database (HGMD): TMPO
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMPO |
|
Disorders
/ Diseases
for TMPO gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TMPO for disorders About GeneDecksing
OMIM gene information: 188380
OMIM disorders: 613740
UniProtKB/Swiss-Prot: LAP2B_HUMAN, P42167
Defects in TMPO are the cause of cardiomyopathy dilated type 1T (CMD1T) [MIM:613740]. A disorder characterizedby ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patientsare at risk of premature death
20/57  diseases for TMPO (see all 57): About MalaCardsdilated cardiomyopathy cardiomyopathy acrodermatitis enteropathica herpes zoster
myasthenia gravis phobic disorder alopecia areata phobia
neuromuscular disease lymphocytic choriomeningitis herpes simplex viral hepatitis
myasthenia oral candidiasis leukopenia enteropathica
hepatitis b diabetes mellitus dysentery bronchitis
1 disease from the University of Copenhagen DISEASES database for TMPO:Myasthenia gravis 10/47 Novoseek disease relationships for TMPO gene (see all 47) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| muscular dystrophy emery-dreifuss |
74.5 |
1 |
10806084 (1) |
| bronchitis chronic |
40.2 |
7 |
2236822 (2), 1306635 (1), 1845435 (1), 2140311 (1) (see all 5) |
| postoperative infection |
35.4 |
6 |
8156337 (4), 8776187 (1), 1565267 (1) |
| aids-related complex |
35.1 |
1 |
7859140 (1) |
| dermatitis atopic |
30.4 |
11 |
8157786 (4), 11145854 (3), 1329673 (2), 2185294 (2) |
| myasthenia gravis |
30.3 |
7 |
20193562 (2), 8332357 (1), 19087694 (1), 17131816 (1) |
| sclerosis systemic |
20 |
3 |
7882698 (2), 1828204 (1) |
| leukopenia |
16.7 |
2 |
2255416 (1), 7516641 (1) |
| phobias |
15.5 |
3 |
2092042 (2) |
| arthritis juvenile rheumatoid |
12.9 |
4 |
1971780 (2), 1376077 (1) |
Human Genome Epidemiology (HuGE) Navigator: TMPO (5 documents)
Export disorders for TMPO gene to outside databases
|
Publications
for TMPO gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TMPO gene, integrated from 9 sources (see all 286):
(articles sorted by number of sources associating them with TMPO) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Three distinct human thymopoietins are derived from alternatively spliced mRNAs. (PubMed id 7517549)1, 2, 3, 9 Harris C.A.... Goldstein G. (1994)
- Structure and mapping of the human thymopoietin (TMPO) gene and relationship of human TMPO beta to rat lamin-associated polypeptide 2. (PubMed id 8530026)1, 2, 9 Harris C.A.... Goldstein G. (1995)
- Review: lamina-associated polypeptide 2 isoforms and related proteins in cell cycle-dependent nuclear structure dynamics. (PubMed id 10806084)1, 2, 9 Dechat T.... Foisner R. (2000)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- HA95 and LAP2 beta mediate a novel chromatin-nuclear envelope interaction implicated in initiation of DNA replication. (PubMed id 12538639)1, 2 Martins S.... Collas P. (2003)
- Structural characterization of the LEM motif common to three human inner nuclear membrane proteins. (PubMed id 11435115)1, 2 Laguri C.... Zinn-Justin S. (2001)
- Solution structure of the constant region of nuclear envelope protein LAP2 reveals two LEM-domain structures: one binds BAF and the other binds DNA. (PubMed id 11500367)1, 2 Cai M.... Clore G.M. (2001)
- Identification of the lamina-associated-polypeptide-2-binding domain of B-type lamin. (PubMed id 9490046)1, 2 Furukawa K. and Kondo T. (1998)
- On the role of thymopoietins in cell proliferation. Immunochemical evidence for new members of the human thymopoietin family. (PubMed id 10430029)1, 9 Weber P.J....Beck-Sickinger A.G. (1999)
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External Searches for TMPO gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing TMPO gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
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Other Databases showing TMPO gene
(According to HUGE)
About This Section
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Specialized Databases showing TMPO gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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| Name | Description |
| PharmGKB entry for TMPO | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for TMPO gene:
Search GeneIP for patents involving TMPO
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for TMPO gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TMPO | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMPO | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMPO | | | OriGene Protein Over-expression Lysate for TMPO | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TMPO | | OriGene 3'-UTR Clone for TMPO | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMPO | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMPO | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for TMPO | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TMPO | | OriGene Custom Protein Services for TMPO | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TMPO | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMPO | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMPO | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMPO | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMPO | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMPO |
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| | Antibodies & Assays for TMPO
(TMPO iso6) |
| | | | Search Tocris compounds for TMPO |
| |  |  |  |  | | | | | | Recombinant Protein for TMPO |
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 | | | TMPO Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMPO |
|  |  |  | | | | ThermoFisher Antibodies for TMPO |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMPO |
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