Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TMPO Gene

Aliases for TMPO Gene

  • LAP2 3 4 6
  • Thymopoietin-Related Peptide Isoforms Beta/Gamma 3 4
  • Thymopoietin-Related Peptide Isoform Alpha 3 4
  • LEM Domain Containing 4 2 3
  • TP Beta/Gamma 3 4
  • Thymopoietin 2 3
  • TP Alpha 3 4
  • CMD1T 3 6
  • Thymopoietin, Isoforms Beta/Gamma 4
  • Lamina-Associated Polypeptide 2 3
  • Thymopoietin Isoform Alpha 4
  • TPRP Isoforms Beta/Gamma 4
  • TPRP Isoform Alpha 4
  • PRO0868 3
  • LEMD4 3
  • TP 3

External Ids for TMPO Gene

Summaries for TMPO Gene

Entrez Gene Summary for TMPO Gene

  • The protein encoded by this gene resides in the nucleus and may play a role in the assembly of the nuclear lamina, and thus help maintain the structural organization of the nuclear envelope. It may function as a receptor for the attachment of lamin filaments to the inner nuclear membrane. Mutations in this gene are associated with dilated cardiomyopathy. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, May 2010]

GeneCards Summary for TMPO Gene

TMPO is a Protein Coding gene. Diseases associated with TMPO include alopecia totalis and nezelof syndrome. Among its related pathways are Cell Cycle, Mitotic and Cell Cycle, Mitotic. GO annotations related to this gene include lamin binding.

UniProtKB/Swiss-Prot for TMPO Gene

  • May be involved in the structural organization of the nucleus and in the post-mitotic nuclear assembly. Plays an important role, together with LMNA, in the nuclear anchorage of RB1

  • TP and TP5 may play a role in T-cell development and function. TP5 is an immunomodulating pentapeptide

  • May help direct the assembly of the nuclear lamina and thereby help maintain the structural organization of the nuclear envelope. Possible receptor for attachment of lamin filaments to the inner nuclear membrane. May be involved in the control of initiation of DNA replication through its interaction with NAKAP95

  • Thymopoietin (TP) and Thymopentin (TP5) may play a role in T-cell development and function. TP5 is an immunomodulating pentapeptide

Gene Wiki entry for TMPO Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMPO Gene

Genomics for TMPO Gene

Genomic Location for TMPO Gene

Start:
98,515,512 bp from pter
End:
98,550,379 bp from pter
Size:
34,868 bases
Orientation:
Plus strand

Genomic View for TMPO Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMPO Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMPO Gene

Regulatory Elements for TMPO Gene

Proteins for TMPO Gene

  • Protein details for TMPO Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P42166-LAP2A_HUMAN
    Recommended name:
    Lamina-associated polypeptide 2, isoform alpha
    Protein Accession:
    P42166
    Secondary Accessions:
    • P08918
    • P08919
    • Q14860
    • Q16295

    Protein attributes for TMPO Gene

    Size:
    694 amino acids
    Molecular mass:
    75492 Da
    Quaternary structure:
    • Interacts with LMNA, BANF1 and RB1 and with chromosomes. Associates directly or indirectly with lamins at specific cell-cycle stages.

    Three dimensional structures from OCA and Proteopedia for TMPO Gene

    Alternative splice isoforms for TMPO Gene

    UniProtKB/Swiss-Prot:
  • Protein details for TMPO Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P42167-LAP2B_HUMAN
    Recommended name:
    Lamina-associated polypeptide 2, isoforms beta/gamma
    Protein Accession:
    P42167
    Secondary Accessions:
    • A2T926
    • Q14861

    Protein attributes for TMPO Gene

    Size:
    454 amino acids
    Molecular mass:
    50670 Da
    Quaternary structure:
    • Interacts with LMNB1, LMNB2, BANF1, AKAP8L, GMCL and chromosomes (By similarity). Isoform Zeta interacts with BANF1/BAF and may sequester it in the cytoplasm.

    Alternative splice isoforms for TMPO Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMPO Gene

Proteomics data for TMPO Gene at MOPED

Post-translational modifications for TMPO Gene

No data available for DME Specific Peptides for TMPO Gene

Domains for TMPO Gene

UniProtKB/Swiss-Prot:

LAP2B_HUMAN
Domain:
  • The N-terminal part contains two structurally independent, non-interacting domains: LEM-like (also called LAP2-N or LEM-D) and LEM (also called LAP2-C or LEM-B). LEM-like binds DNA while LEM interacts with BANF1:
    • P42166
  • The C-terminal domain forms a four-stranded coiled coil.:
    • P42166
  • Contains 1 LEM domain.:
    • P42166
    • P42167
  • Contains 1 LEM-like domain.:
    • P42166
    • P42167
  • Has two structurally independent, non-interacting domains: LEM-like (also called LAP2-N or LEM-D) and LEM (also called LAP2-C or LEM-B). LEM-like binds DNA while LEM interacts with BANF1:
    • P42167
Family:
  • Belongs to the LEM family.:
    • P42166
    • P42167
genes like me logo Genes that share domains with TMPO: view

No data available for Gene Families for TMPO Gene

Function for TMPO Gene

Molecular function for TMPO Gene

GENATLAS Biochemistry: thymopoietin,nuclear precursor of subunits alpha (75kDa),beta (51kDa),gamma (39kDa),LAP2 (lamina-associated protein 2) family
UniProtKB/Swiss-Prot Function: May be involved in the structural organization of the nucleus and in the post-mitotic nuclear assembly. Plays an important role, together with LMNA, in the nuclear anchorage of RB1
UniProtKB/Swiss-Prot Function: TP and TP5 may play a role in T-cell development and function. TP5 is an immunomodulating pentapeptide
UniProtKB/Swiss-Prot Function: May help direct the assembly of the nuclear lamina and thereby help maintain the structural organization of the nuclear envelope. Possible receptor for attachment of lamin filaments to the inner nuclear membrane. May be involved in the control of initiation of DNA replication through its interaction with NAKAP95
UniProtKB/Swiss-Prot Function: Thymopoietin (TP) and Thymopentin (TP5) may play a role in T-cell development and function. TP5 is an immunomodulating pentapeptide

Gene Ontology (GO) - Molecular Function for TMPO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 17474147
GO:0005521 lamin binding TAS 8530026
genes like me logo Genes that share ontologies with TMPO: view
genes like me logo Genes that share phenotypes with TMPO: view

Animal Models for TMPO Gene

MGI Knock Outs for TMPO:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for TMPO Gene

Localization for TMPO Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMPO Gene

Nucleus. Chromosome. Note=Expressed diffusely throughout the nucleus.
Nucleus inner membrane; Single-pass type II membrane protein. Note=Tightly associated with the nuclear lamina.
Isoform Zeta: Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMPO Gene COMPARTMENTS Subcellular localization image for TMPO gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for TMPO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 chromatin IDA 17284516
GO:0005634 nucleus TAS 8530026
GO:0005635 nuclear envelope TAS 8530026
GO:0005637 nuclear inner membrane IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with TMPO: view

Pathways for TMPO Gene

genes like me logo Genes that share pathways with TMPO: view

Pathways by source for TMPO Gene

Gene Ontology (GO) - Biological Process for TMPO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with TMPO: view

Compounds for TMPO Gene

UniProtKB/Swiss-Prot:

P42166-LAP2A_HUMAN
Pharmaceutical: TP5 is available under the names Timunox (Cilag), Sintomodulina (Italofarmaco) and Mepentil (Recordati). Used in primary and secondary immune deficiencies, autoimmunity, infections and cancer

(34) Novoseek inferred chemical compound relationships for TMPO Gene

Compound -log(P) Hits PubMed IDs
thymopentin 99 204
splenin 96.4 26
thymotrinan 87.1 1
sodium nucleinate 83 6
vilozen 81.7 2
genes like me logo Genes that share compounds with TMPO: view

Transcripts for TMPO Gene

Unigene Clusters for TMPO Gene

Thymopoietin:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMPO Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b
SP1: - - -
SP2: - - - - - -
SP3: -
SP4:
SP5:

Relevant External Links for TMPO Gene

GeneLoc Exon Structure for
TMPO
ECgene alternative splicing isoforms for
TMPO

Expression for TMPO Gene

mRNA expression in normal human tissues for TMPO Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TMPO Gene

SOURCE GeneReport for Unigene cluster for TMPO Gene Hs.11355

mRNA Expression by UniProt/SwissProt for TMPO Gene

P42166-LAP2A_HUMAN
Tissue specificity: Expressed in many tissues. Most abundant in adult thymus and fetal liver
genes like me logo Genes that share expressions with TMPO: view

Orthologs for TMPO Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMPO Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMPO 36
  • 99.71 (n)
  • 99.56 (a)
TMPO 37
  • 52 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMPO 36
  • 75.45 (n)
  • 70.7 (a)
TMPO 37
  • 46 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMPO 36
  • 94.78 (n)
  • 94.48 (a)
TMPO 37
  • 51 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmpo 36
  • 89.75 (n)
  • 91.15 (a)
Tmpo 16
Tmpo 37
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMPO 37
  • 42 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMPO 37
  • 38 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmpo 36
  • 89.75 (n)
  • 90.27 (a)
chicken
(Gallus gallus)
Aves TMPO 36
  • 80.26 (n)
  • 76.5 (a)
TMPO 37
  • 41 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMPO 37
  • 37 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.464 36
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75950 36
tmpo 36
  • 69.58 (n)
  • 62.17 (a)
zebrafish
(Danio rerio)
Actinopterygii tmpo 36
TMPO (3 of 3) 37
  • 28 (a)
OneToMany
tmpoa 36
  • 59.21 (n)
  • 59.11 (a)
tmpoa 37
  • 25 (a)
OneToMany
tmpob 37
  • 30 (a)
OneToMany
Species with no ortholog for TMPO:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMPO Gene

ENSEMBL:
Gene Tree for TMPO (if available)
TreeFam:
Gene Tree for TMPO (if available)

Paralogs for TMPO Gene

Pseudogenes.org Pseudogenes for TMPO Gene

genes like me logo Genes that share paralogs with TMPO: view

No data available for Paralogs for TMPO Gene

Variants for TMPO Gene

Sequence variations from dbSNP and Humsavar for TMPO Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs171615 -- 98,518,494(+) ttttt(G/T)ggtac intron-variant
rs1044435 -- 98,549,916(+) TCTCT(C/G)AGTAA utr-variant-3-prime
rs1044514 -- 98,550,228(+) CTTGA(C/T)GTAAA utr-variant-3-prime
rs1058288 - 98,547,774(+) TTTTT(G/T)TTTTT reference, missense
rs1058300 Likely benign 98,547,859(+) ACTGA(A/G)TGGTA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TMPO Gene

Variant ID Type Subtype PubMed ID
nsv7234 OTHER Inversion 18451855
esv2601754 CNV Deletion 19546169

Relevant External Links for TMPO Gene

HapMap Linkage Disequilibrium report
TMPO
Human Gene Mutation Database (HGMD)
TMPO

Disorders for TMPO Gene

(1) OMIM Diseases for TMPO Gene (188380)

UniProtKB/Swiss-Prot

LAP2B_HUMAN
  • Cardiomyopathy, dilated 1T (CMD1T) [MIM:613740]: A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. {ECO:0000269 PubMed:16247757}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(2) University of Copenhagen DISEASES for TMPO Gene

(47) Novoseek inferred disease relationships for TMPO Gene

Disease -log(P) Hits PubMed IDs
muscular dystrophy emery-dreifuss 74.5 1
bronchitis chronic 40.2 6
postoperative infection 35.4 6
aids-related complex 35.1 1
dermatitis atopic 30.4 11

Relevant External Links for TMPO

Genetic Association Database (GAD)
TMPO
Human Genome Epidemiology (HuGE) Navigator
TMPO
genes like me logo Genes that share disorders with TMPO: view

Publications for TMPO Gene

  1. Three distinct human thymopoietins are derived from alternatively spliced mRNAs. (PMID: 7517549) Harris C.A. … Goldstein G. (Proc. Natl. Acad. Sci. U.S.A. 1994) 2 3 4 23
  2. Structure and mapping of the human thymopoietin (TMPO) gene and relationship of human TMPO beta to rat lamin-associated polypeptide 2. (PMID: 8530026) Harris C.A. … Goldstein G. (Genomics 1995) 3 4 23
  3. Review: lamina-associated polypeptide 2 isoforms and related proteins in cell cycle-dependent nuclear structure dynamics. (PMID: 10806084) Dechat T. … Foisner R. (J. Struct. Biol. 2000) 3 4 23
  4. On the role of thymopoietins in cell proliferation. Immunochemical evidence for new members of the human thymopoietin family. (PMID: 10430029) Weber P.J. … Beck-Sickinger A.G. (Biol. Chem. 1999) 3 23
  5. The major nuclear envelope targeting domain of LAP2 coincides with its lamin binding region but is distinct from its chromatin interaction domain. (PMID: 9461618) Furukawa K. … Gerace L. (J. Biol. Chem. 1998) 3 23

Products for TMPO Gene

  • Addgene plasmids for TMPO

Sources for TMPO Gene

Back to Top

Content