Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TMOD4 Gene

protein-coding   GIFtS: 50
GCID: GC01M151142

tropomodulin 4 (muscle)

 Explore 4 diseases affiliated with
TMOD4 via our new
 Human Malady Compendium 
Biological research products
for TMOD4
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Tropomodulin 4 (Muscle)1 2
Sk-Tmod1 3
Skeletal Muscle Tropomodulin2 3
SK-TMOD2
Actin-Capping Protein2
Tropomodulin-41

External Ids:    HGNC: 118741   Entrez Gene: 297652   Ensembl: ENSG000001631577   OMIM: 6058345   UniProtKB: Q9NZQ93   

Export aliases for TMOD4 gene to outside databases

Previous GC identifers: GC01U990301 GC01M146889 GC01M147917 GC01M148359 GC01M147955 GC01M149409 GC01M122520


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: TMOD4_HUMAN, Q9NZQ9
Function: Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex
contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane
skeleton

Gene Wiki entry for TMOD4


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TMOD4 gene promoter:
         Nkx3-1   Sox5   NRSF form 1   NRSF form 2   RORalpha2   GATA-2   MZF-1   Sox9   IRF-7A   Nkx3-1 v3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMOD4 promoter sequence
   Search SABiosciences Chromatin IP Primers for TMOD4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMOD4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q12   Ensembl cytogenetic band:  1q21.3   HGNC cytogenetic band: 1q12

TMOD4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMOD4 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M151142:  view genomic region     (about GC identifiers)

Start:
151,142,462 bp from pter      End:
151,148,547 bp from pter
Size:
6,086 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TMOD4_HUMAN, Q9NZQ9 (See protein sequence)
Recommended Name: Tropomodulin-4  
Size: 345 amino acids; 39335 Da
Subunit: Binds to the N-terminus of tropomyosin and to actin
Subcellular location: Cytoplasm, cytoskeleton
Secondary accessions: Q5JR83 Q8WVL3 Q9UKH2

Explore the universe of human proteins at neXtProt for TMOD4: NX_Q9NZQ9

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9NZQ9

  • TMOD4 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_037485.2  
    ENSEMBL proteins: 
     ENSP00000468006   ENSP00000295314   ENSP00000468489   ENSP00000406333   ENSP00000414180  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: TMOD4
    OriGene Protein Over-expression Lysate: TMOD4
    OriGene Custom Protein Services for TMOD4 
    GenScript Custom Purified and Recombinant Proteins Services for TMOD4
    Novus Biologicals TMOD4 Protein
    Novus Biologicals TMOD4 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for TMOD4

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005856cytoskeleton ----
    GO:0005865striated muscle thin filament IEA--


    TMOD4 for ontologies           About GeneDecksing



    TMOD4 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for TMOD4 
    GenScript Custom Superior Antibodies Services for TMOD4
    Novus Biologicals TMOD4 Antibodies
    Search for Antibodies for TMOD4 at Abcam  
    Uscn Antibodies for TMOD4
    Search ThermoFisher Antibodies for TMOD4

    Assay Products for TMOD4: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TMOD4
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for TMOD4


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TMOD4 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR004934 Tropomodulin

    Graphical View of Domain Structure for InterPro Entry Q9NZQ9

    ProtoNet protein and cluster: Q9NZQ9

    1 Blocks protein family: IPB004934 Tropomodulin

    UniProtKB/Swiss-Prot: TMOD4_HUMAN, Q9NZQ9
    Similarity: Belongs to the tropomodulin family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: TMOD4_HUMAN, Q9NZQ9
    Function: Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex
    contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane
    skeleton

         Genatlas biochemistry entry for TMOD4:
    tropomodulin 4,expressed in muscle

    miRNA
    Products:
        
    Browse 3'-UTR reporter clones for miRNA target validation
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TMOD4
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate TMOD4
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMOD4 (see all 7)
    OriGene shRNA RFP: TMOD4
    OriGene siRNA: TMOD4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMOD4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TMOD4

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMOD4 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMOD4
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: TMOD4 (NM_013353)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMOD4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMOD4 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TMOD4
    Search LifeMap BioReagents cell lines for TMOD4

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMOD4

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
    GO:0005523tropomyosin binding IEA--


    TMOD4 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for TMOD4:
     Lamellipodia cells 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TMOD4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    5/12 Interacting proteins for TMOD4 (Q9NZQ93 ENSP000002953144) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NEBP209293, ENSP000003862594I2D: score=1 STRING: ENSP00000386259
    CTSKENSP000002716514STRING: ENSP00000271651
    VPS72ENSP000003578874STRING: ENSP00000357887
    APOBEC4ENSP000003106224STRING: ENSP00000310622
    CELA3AENSP000002901224STRING: ENSP00000290122
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006936muscle contraction TAS10662549


    TMOD4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TMOD4 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TMOD4
    2 Novoseek chemical compound relationships for TMOD4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cytochalasin d 49.4 1 15772946 (1)
    calcium 0 2 2255912 (1), 10880956 (1)

    Search CenterWatch for drugs/clinical trials and news about TMOD4 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TMOD4 gene: 
    NM_013353.2  

    Unigene Cluster for TMOD4:

    Tropomodulin 4 (muscle)
    Hs.709681  [show with all ESTs]
    Unigene Representative Sequence: NM_013353
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000466891 ENST00000477354(uc001exb.3) ENST00000295314(uc001exd.3)
    ENST00000463543 ENST00000488488 ENST00000441701 ENST00000416280

    miRNA
    Products:
         
    Browse 3'-UTR reporter clones for miRNA target validation
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TMOD4
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate TMOD4
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMOD4 (see all 7)
    OriGene shRNA RFP: TMOD4
    OriGene siRNA: TMOD4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMOD4
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMOD4 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMOD4
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: TMOD4 (NM_013353)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMOD4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMOD4 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMOD4
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TMOD4
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMOD4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMOD4

    Additional cDNA sequence: 

    AF165217.1 AF177173.2 AK300675.1 AK313280.1 BC017810.1 BX647346.1 

    6 DOTS entries:

    DT.213955  DT.101983057  DT.100019640  DT.454033  DT.121409560  DT.97785845 

    24/350 AceView cDNA sequences (see all 350):

    BX342187 BM697514 AL556957 BU957427 BM423730 BU149622 BF725898 CB138787 
    BF983909 F22078 F25418 BU155042 AW298441 BQ774512 BM792617 AU099529 
    F26424 AL555553 CR621971 BM752428 CB305381 AA662387 CB528336 BG575391 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TMOD4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ACCCGAAACA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    TMOD4 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10/15 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 15
    Tissue Anatomical Compartment CellCategory (developmental path)
    LimbForelimb Dorsal MusclesMultinuclear MyocytesSkeletal Muscle
    LimbForelimb Ventral MusclesMultinuclear MyocytesSkeletal Muscle
    LimbHindlimb Dorsal MuscleMultinuclear MyocytesSkeletal Muscle
    LimbHindlimb Ventral MuscleMultinuclear MyocytesSkeletal Muscle
    Skeletal MuscleAnterior Neck MusclesMultinuclear MyocytesSkeletal Muscle
    Skeletal MuscleCervical Back MusclesMultinuclear MyocytesSkeletal Muscle
    Skeletal MuscleLumbar Back MusclesMultinuclear MyocytesSkeletal Muscle
    Skeletal MuscleLumbar Vertebrae Column MusclesMultinuclear MyocytesSkeletal Muscle
    Skeletal MusclePelvic MusclesMultinuclear MyocytesSkeletal Muscle
    Skeletal MusclePosterior Neck MusclesMultinuclear MyocytesSkeletal Muscle
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See TMOD4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TMOD4

    SOURCE GeneReport for Unigene cluster: Hs.709681

    UniProtKB/Swiss-Prot: TMOD4_HUMAN, Q9NZQ9
    Tissue specificity: Highly expressed in skeletal muscle

        SABiosciences Custom PCR Arrays for TMOD4
    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMOD4
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TMOD4
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMOD4
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMOD4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMOD4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TMOD4 gene from 6/21 species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves LOC1008575131 tropomodulin-4-like 72.58(n)
    77.91(a)
      100857513  XM_003642690.1  XP_003642738.1 
    lizard
    (Anolis carolinensis)
    Reptilia TMOD46
    --
    71(a)
    1 ↔ 1
    GL343668.1(147391-176583)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.247842 Xenopus laevis transcribed sequence with weak similarity more 78.41(n)    BJ033962.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tmod42 tropomodulin 4 (muscle) 76.42(n)   30441  AF165216.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta spdo3 peripheral nervous system development actin
    binding
    34(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea tmd-26
    unc-946
    Tropomodulin
    9(a)
    28(a)
    many ↔ many
    many ↔ many
    V(8336638-8340655)
    I(5992672-6001101)


    ENSEMBL Gene Tree for TMOD4 (if available)
    TreeFam Gene Tree for TMOD4 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TMOD4 gene
    LMOD32  TMOD12  LMOD22  TMOD32  LMOD12  TMOD22  
    6 SIMAP similar genes for TMOD4 using alignment to 6 protein entries:     TMOD4_HUMAN (see all proteins):
    TMOD1    DKFZp686E1899    TMOD2    TMOD3    LMOD2    LMOD3

    TMOD4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/118 NCBI SNPs in TMOD4 are shown (see all 118    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1857441401,2
    --151141972(+) ACCTCG/TGCCTC 5 -- ut31 nc-transcript-variantds50010--------
    rs727084551,2
    C,F,--151142070(+) CATGCC/TAAGCG 5 -- ut31 nc-transcript-variantds50011Minor allele frequency- T:0.04NA 120
    rs1459658161,2
    --151142178(+) CTTTCC/TCCCTT 5 -- ut31 nc-transcript-variantds50010--------
    rs1167271181,2
    --151142195(+) ACATAA/TGGACT 5 -- ut31 nc-transcript-variantds50011Minor allele frequency- T:0.01WA 118
    rs412996091,2
    F,--151142203(+) ACTGCA/GGGTAG 5 -- ds5001 nc-transcript-variantut311Minor allele frequency- G:0.07WA 118
    rs1902713511,2
    --151142219(+) AGGGGC/GACCTG 5 -- ds5001 ut31 nc-transcript-variant0--------
    rs729940351,2
    C,--151142276(+) AAGAGT/ACAAAA 5 -- ds5001 nc-transcript-variantut311Minor allele frequency- A:0.50WA 2
    rs1998307311,2
    --151142521(+) TCCAGC/TGCTCC 5 -- ut31 nc-transcript-variant0--------
    rs287307201,2
    C,F,H,--151142530(-) CTAGCG/ACTGGG 5 -- nc-transcript-variantut31 ese37Minor allele frequency- A:0.01NS NA EU 1677
    rs1385506741,2
    --151142677(+) ATAAAC/TTGGTA 5 -- int1 nc-transcript-variantut310--------

    HapMap Linkage Disequilibrium report for TMOD4 (151142462 - 151148547 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for TMOD4: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMOD4
    DNA2.0 Custom Variant and Variant Library Synthesis for TMOD4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TMOD4 for disorders           About GeneDecksing

    OMIM gene information: 605834    OMIM disorders: --

    4 diseases for TMOD4:    About MalaCards
    osteosarcoma    pancreatic cancer    pancreatitis    neuronitis

    1 Novoseek disease relationship for TMOD4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    osteosarcoma 39.1 2 19212829 (1)


    Export disorders for TMOD4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TMOD4 gene, integrated from 9 sources (see all 55):
    (articles sorted by number of sources associating them with TMOD4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sequencing, expression analysis, and mapping of three unique human tropomodulin genes and their mouse orthologs. (PubMed id 10662549)1, 2, 3, 9 Cox P.R. and Zoghbi H.Y. (2000)
    2. Identification of a novel tropomodulin isoform, skeletal tropomodulin, that caps actin filament pointed ends in fast skeletal muscle. (PubMed id 10497209)1, 2, 3 Almenar-Queralt A....Fowler V.M. (1999)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Genomic organization of Tropomodulins 2 and 4 and unusual intergenic and intraexonic splicing of YL-1 and Tropomodulin 4. (PubMed id 11716785)1, 9 Cox P.R....Zoghbi H.Y. (2001)
    5. The N-terminal end of nebulin interacts with tropomodulin at the pointed ends of the thin filaments. (PubMed id 11016930)1, 9 McElhinny A.S....Gregorio C.C. (2001)
    6. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    7. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
    8. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 29765 HGNC: 11874 AceView: TCFL1andTMOD4 Ensembl:ENSG00000163157 euGenes: HUgn29765
    ECgene: TMOD4 H-InvDB: TMOD4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TMOD4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TMOD4 gene:
    Search GeneIP for patents involving TMOD4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for TMOD4  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMOD4   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMOD4  
     OriGene Protein Over-expression Lysate for TMOD4   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for TMOD4   Browse 3'-UTR reporter clones for miRNA target validation  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMOD4   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMOD4  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for TMOD4   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TMOD4   OriGene Custom Protein Services for TMOD4  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TMOD4
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMOD4
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMOD4
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMOD4
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMOD4
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMOD4
     GenScript Custom Purified and Recombinant Proteins Services for TMOD4 GenScript cDNA clones with any tag delivered in your preferred vector for TMOD4
     GenScript Custom Assay Services for TMOD4 GenScript Custom Superior Antibodies Services for TMOD4
     GenScript Custom overexpressing Cell Line Services for TMOD4 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in TMOD4 promoter
     Search Chromatin IP Primers for TMOD4
     RT2 qPCR Primer Assay in human, mouse, rat TMOD4
     GNC Network for TMOD4
     SABiosciences Custom PCR Arrays for TMOD4
     Search Tocris compounds for TMOD4
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     TMOD4 antibodies
     TMOD4 proteins
     TMOD4 lysates
     Search for Antibodies for TMOD4 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for TMOD4
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     TMOD4 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for TMOD4
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMOD4
     Browse SwitchGear 3'UTR luciferase reporter plasmids for TMOD4
     SwitchGear Promoter luciferase reporter plasmids for TMOD4
     Search ThermoFisher Antibodies for TMOD4
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMOD4
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TMOD4 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4