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Aliases for TMOD4 Gene

Aliases for TMOD4 Gene

  • Skeletal Muscle Tropomodulin 3 4
  • Tropomodulin 4 (Muscle) 2 3
  • Actin-Capping Protein 2 3
  • SK-TMOD 3 4
  • Tropomodulin-4 3

External Ids for TMOD4 Gene

Summaries for TMOD4 Gene

GeneCards Summary for TMOD4 Gene

TMOD4 is a Protein Coding gene. GO annotations related to this gene include actin binding and tropomyosin binding. An important paralog of this gene is LMOD1.

UniProtKB/Swiss-Prot for TMOD4 Gene

  • Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton

Gene Wiki entry for TMOD4 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMOD4 Gene

Genomics for TMOD4 Gene

Genomic Location for TMOD4 Gene

Start:
151,169,986 bp from pter
End:
151,176,284 bp from pter
Size:
6,299 bases
Orientation:
Minus strand

Genomic View for TMOD4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMOD4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMOD4 Gene

Regulatory Elements for TMOD4 Gene

Proteins for TMOD4 Gene

  • Protein details for TMOD4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NZQ9-TMOD4_HUMAN
    Recommended name:
    Tropomodulin-4
    Protein Accession:
    Q9NZQ9
    Secondary Accessions:
    • B7Z6N9
    • Q5JR83
    • Q8WVL3
    • Q9UKH2

    Protein attributes for TMOD4 Gene

    Size:
    345 amino acids
    Molecular mass:
    39335 Da
    Quaternary structure:
    • Binds to the N-terminus of tropomyosin and to actin

    Alternative splice isoforms for TMOD4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMOD4 Gene

Proteomics data for TMOD4 Gene at MOPED

Post-translational modifications for TMOD4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMOD4 Gene

No data available for DME Specific Peptides for TMOD4 Gene

Domains for TMOD4 Gene

Protein Domains for TMOD4 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

TMOD4_HUMAN
Family:
  • Belongs to the tropomodulin family.:
    • Q9NZQ9
genes like me logo Genes that share domains with TMOD4: view

No data available for Gene Families for TMOD4 Gene

Function for TMOD4 Gene

Molecular function for TMOD4 Gene

GENATLAS Biochemistry: tropomodulin 4,expressed in muscle
UniProtKB/Swiss-Prot Function: Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton

Gene Ontology (GO) - Molecular Function for TMOD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding --
GO:0005523 tropomyosin binding IEA --
GO:0051015 actin filament binding IEA --
genes like me logo Genes that share ontologies with TMOD4: view

Phenotypes for TMOD4 Gene

GenomeRNAi human phenotypes for TMOD4:
genes like me logo Genes that share phenotypes with TMOD4: view

miRNA for TMOD4 Gene

miRTarBase miRNAs that target TMOD4

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TMOD4 Gene

Localization for TMOD4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMOD4 Gene

Cytoplasm, cytoskeleton. Note=In myofibrils with sarcomeric structure, localizes to the pointed end of actin thin filaments (PubMed:25250574). {ECO:0000269 PubMed:25250574}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMOD4 Gene COMPARTMENTS Subcellular localization image for TMOD4 gene
Compartment Confidence
cytoskeleton 5
cytosol 3
nucleus 2

Gene Ontology (GO) - Cellular Components for TMOD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005856 cytoskeleton --
GO:0005865 striated muscle thin filament IBA --
genes like me logo Genes that share ontologies with TMOD4: view

Pathways for TMOD4 Gene

SuperPathways for TMOD4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMOD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006936 muscle contraction TAS 10662549
GO:0007015 actin filament organization IBA --
GO:0030239 myofibril assembly IBA --
GO:0051694 pointed-end actin filament capping IEA --
genes like me logo Genes that share ontologies with TMOD4: view

No data available for Pathways by source for TMOD4 Gene

Compounds for TMOD4 Gene

(2) Novoseek inferred chemical compound relationships for TMOD4 Gene

Compound -log(P) Hits PubMed IDs
cytochalasin d 49.4 1
calcium 0 2
genes like me logo Genes that share compounds with TMOD4: view

Transcripts for TMOD4 Gene

Unigene Clusters for TMOD4 Gene

Tropomodulin 4 (muscle):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMOD4 Gene

No ASD Table

Relevant External Links for TMOD4 Gene

GeneLoc Exon Structure for
TMOD4
ECgene alternative splicing isoforms for
TMOD4

Expression for TMOD4 Gene

mRNA expression in normal human tissues for TMOD4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMOD4 Gene

This gene is overexpressed in Muscle - Skeletal (49.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TMOD4 Gene

SOURCE GeneReport for Unigene cluster for TMOD4 Gene Hs.709681

mRNA Expression by UniProt/SwissProt for TMOD4 Gene

Q9NZQ9-TMOD4_HUMAN
Tissue specificity: Highly expressed in skeletal muscle.
genes like me logo Genes that share expressions with TMOD4: view

Orthologs for TMOD4 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMOD4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMOD4 36
  • 99.9 (n)
  • 100 (a)
TMOD4 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMOD4 36
  • 92.95 (n)
  • 96.81 (a)
TMOD4 37
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMOD4 36
  • 92.75 (n)
  • 97.1 (a)
TMOD4 37
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmod4 36
  • 90.43 (n)
  • 96.23 (a)
Tmod4 16
Tmod4 37
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMOD4 37
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMOD4 37
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmod4 36
  • 89.95 (n)
  • 96.23 (a)
chicken
(Gallus gallus)
Aves LOC100857513 36
  • 72.58 (n)
  • 77.91 (a)
SKTMOD 37
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMOD4 37
  • 71 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.24784 36
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.17389 36
tmod4 36
  • 69.59 (n)
  • 74.56 (a)
zebrafish
(Danio rerio)
Actinopterygii tmod4 36
  • 68.87 (n)
  • 69.67 (a)
tmod4 37
  • 67 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta spdo 38
  • 34 (a)
Species with no ortholog for TMOD4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMOD4 Gene

ENSEMBL:
Gene Tree for TMOD4 (if available)
TreeFam:
Gene Tree for TMOD4 (if available)

Paralogs for TMOD4 Gene

Paralogs for TMOD4 Gene

Selected SIMAP similar genes for TMOD4 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with TMOD4: view

Variants for TMOD4 Gene

Sequence variations from dbSNP and Humsavar for TMOD4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs3811404 -- 151,170,913(+) GGGAA(C/T)GCTGA intron-variant
rs7521416 -- 151,173,800(+) GGGGC(C/T)GGGCG intron-variant
rs7552226 -- 151,173,710(+) TGCTG(C/G)GTCAC intron-variant
rs17851567 -- 151,174,473(+) AGGGC(C/T)TCTCG synonymous-codon, reference
rs28606500 -- 151,173,715(+) CGTCA(C/G)GAAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMOD4 Gene

Variant ID Type Subtype PubMed ID
nsv522840 CNV Gain 19592680
dgv2n68 CNV Loss 17160897

Relevant External Links for TMOD4 Gene

HapMap Linkage Disequilibrium report
TMOD4

Disorders for TMOD4 Gene

(1) Novoseek inferred disease relationships for TMOD4 Gene

Disease -log(P) Hits PubMed IDs
osteosarcoma 39.1 1
genes like me logo Genes that share disorders with TMOD4: view

No data available for UniProtKB/Swiss-Prot for TMOD4 Gene

Publications for TMOD4 Gene

  1. Sequencing, expression analysis, and mapping of three unique human tropomodulin genes and their mouse orthologs. (PMID: 10662549) Cox P.R. … Zoghbi H.Y. (Genomics 2000) 2 3 4 23
  2. Identification of a novel tropomodulin isoform, skeletal tropomodulin, that caps actin filament pointed ends in fast skeletal muscle. (PMID: 10497209) Almenar-Queralt A. … Fowler V.M. (J. Biol. Chem. 1999) 2 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. The N-terminal end of nebulin interacts with tropomodulin at the pointed ends of the thin filaments. (PMID: 11016930) McElhinny A.S. … Gregorio C.C. (J. Biol. Chem. 2001) 3 23

Products for TMOD4 Gene

Sources for TMOD4 Gene

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