Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TMOD4 Gene

Aliases for TMOD4 Gene

  • Tropomodulin 4 2 3 5
  • Skeletal Muscle Tropomodulin 3 4
  • Tropomodulin 4 (Muscle) 2 3
  • Actin-Capping Protein 2 3
  • Skeletal Tropomodulin 2 3
  • SK-TMOD 3 4
  • Tropomodulin-4 3

External Ids for TMOD4 Gene

Previous GeneCards Identifiers for TMOD4 Gene

  • GC01U990301
  • GC01M146889
  • GC01M147917
  • GC01M148359
  • GC01M147955
  • GC01M149409
  • GC01M122520

Summaries for TMOD4 Gene

GeneCards Summary for TMOD4 Gene

TMOD4 (Tropomodulin 4) is a Protein Coding gene. Among its related pathways are Cardiac conduction and Striated Muscle Contraction. GO annotations related to this gene include actin binding and tropomyosin binding. An important paralog of this gene is TMOD1.

UniProtKB/Swiss-Prot for TMOD4 Gene

  • Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton.

Gene Wiki entry for TMOD4 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMOD4 Gene

Genomics for TMOD4 Gene

Regulatory Elements for TMOD4 Gene

Enhancers for TMOD4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G151193 2 FANTOM5 Ensembl ENCODE dbSUPER 13.3 -21.3 -21343 7.7 CREB3L1 DMAP1 YY1 ZNF143 ZNF263 NFYC NR2C1 NBN KDM1A SP7 LYSMD1 SETDB1 BNIPL PSMD4 GOLPH3L PRPF3 UBE2D3P3 TMOD4 MRPL9 RPS10P6
GH01G151308 2 FANTOM5 Ensembl ENCODE dbSUPER 9.5 -135.6 -135633 6.1 CREB3L1 AGO1 ZFP64 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 ZNF263 SP3 MRPL9 GABPB2 SETDB1 GOLPH3L LYSMD1 PRPF3 UBE2D3P3 ZNF687 ADAMTSL4 RFX5
GH01G150998 1.6 Ensembl ENCODE dbSUPER 9.5 +176.9 176927 1.2 PKNOX1 FOXA2 CREB3L1 ARNT MLX ARID4B SIN3A DMAP1 ZBTB7B YY1 RNU6-884P CERS2 ENSG00000231073 BNIPL C1orf56 SCNM1 LYSMD1 TMOD4 MINDY1 ANXA9
GH01G151004 1.5 ENCODE dbSUPER 9.6 +168.9 168860 5.2 CREB3L1 MLX ZFP64 YBX1 DMAP1 FEZF1 YY1 ZNF143 ZNF263 SP3 PRPF3 SETDB1 UBE2D3P3 MRPL9 GOLPH3L GABPB2 LYSMD1 CTSK HORMAD1 RN7SL444P
GH01G151142 1.3 ENCODE dbSUPER 11 +31.1 31096 6.1 HDGF PKNOX1 ATF1 FOXA2 ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZNF48 BNIPL GABPB2 SEMA6C PRUNE1 TMOD4 VPS72 PIP5K1A RNU6-884P LYSMD1 C1orf56
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMOD4 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMOD4 Gene

Chromosome:
1
Start:
151,169,986 bp from pter
End:
151,176,304 bp from pter
Size:
6,319 bases
Orientation:
Minus strand

Genomic View for TMOD4 Gene

Genes around TMOD4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMOD4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMOD4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMOD4 Gene

Proteins for TMOD4 Gene

  • Protein details for TMOD4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NZQ9-TMOD4_HUMAN
    Recommended name:
    Tropomodulin-4
    Protein Accession:
    Q9NZQ9
    Secondary Accessions:
    • B7Z6N9
    • Q5JR83
    • Q8WVL3
    • Q9UKH2

    Protein attributes for TMOD4 Gene

    Size:
    345 amino acids
    Molecular mass:
    39335 Da
    Quaternary structure:
    • Binds to the N-terminus of tropomyosin and to actin.

    Alternative splice isoforms for TMOD4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMOD4 Gene

Post-translational modifications for TMOD4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMOD4 Gene

No data available for DME Specific Peptides for TMOD4 Gene

Domains & Families for TMOD4 Gene

Gene Families for TMOD4 Gene

Protein Domains for TMOD4 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9NZQ9

UniProtKB/Swiss-Prot:

TMOD4_HUMAN :
  • Belongs to the tropomodulin family.
Family:
  • Belongs to the tropomodulin family.
genes like me logo Genes that share domains with TMOD4: view

Function for TMOD4 Gene

Molecular function for TMOD4 Gene

GENATLAS Biochemistry:
tropomodulin 4,expressed in muscle
UniProtKB/Swiss-Prot Function:
Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton.

Gene Ontology (GO) - Molecular Function for TMOD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005523 tropomyosin binding IEA --
GO:0051015 actin filament binding IEA --
genes like me logo Genes that share ontologies with TMOD4: view
genes like me logo Genes that share phenotypes with TMOD4: view

Animal Models for TMOD4 Gene

MGI Knock Outs for TMOD4:

Animal Model Products

CRISPR Products

miRNA for TMOD4 Gene

miRTarBase miRNAs that target TMOD4

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TMOD4 Gene

Localization for TMOD4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMOD4 Gene

Cytoplasm, cytoskeleton. Note=In myofibrils with sarcomeric structure, localizes to the pointed end of actin thin filaments (PubMed:25250574). {ECO:0000269 PubMed:25250574}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMOD4 gene
Compartment Confidence
cytoskeleton 4
cytosol 3
nucleus 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for TMOD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0005865 striated muscle thin filament IEA --
genes like me logo Genes that share ontologies with TMOD4: view

Pathways & Interactions for TMOD4 Gene

genes like me logo Genes that share pathways with TMOD4: view

Pathways by source for TMOD4 Gene

1 Sino Biological pathway for TMOD4 Gene
2 Reactome pathways for TMOD4 Gene

Gene Ontology (GO) - Biological Process for TMOD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006936 muscle contraction TAS 10662549
GO:0051694 pointed-end actin filament capping IEA --
genes like me logo Genes that share ontologies with TMOD4: view

No data available for SIGNOR curated interactions for TMOD4 Gene

Drugs & Compounds for TMOD4 Gene

(2) Drugs for TMOD4 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with TMOD4: view

Transcripts for TMOD4 Gene

Unigene Clusters for TMOD4 Gene

Tropomodulin 4 (muscle):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMOD4 Gene

No ASD Table

Relevant External Links for TMOD4 Gene

GeneLoc Exon Structure for
TMOD4
ECgene alternative splicing isoforms for
TMOD4

Expression for TMOD4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMOD4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMOD4 Gene

This gene is overexpressed in Muscle - Skeletal (x49.2).

Protein differential expression in normal tissues from HIPED for TMOD4 Gene

This gene is overexpressed in Esophagus (43.0) and Brain (26.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TMOD4 Gene



Protein tissue co-expression partners for TMOD4 Gene

NURSA nuclear receptor signaling pathways regulating expression of TMOD4 Gene:

TMOD4

SOURCE GeneReport for Unigene cluster for TMOD4 Gene:

Hs.709681

mRNA Expression by UniProt/SwissProt for TMOD4 Gene:

Q9NZQ9-TMOD4_HUMAN
Tissue specificity: Highly expressed in skeletal muscle.

Evidence on tissue expression from TISSUES for TMOD4 Gene

  • Muscle(4.9)
genes like me logo Genes that share expression patterns with TMOD4: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for TMOD4 Gene

Orthologs for TMOD4 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMOD4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMOD4 34 35
  • 99.9 (n)
cow
(Bos Taurus)
Mammalia TMOD4 34 35
  • 92.95 (n)
dog
(Canis familiaris)
Mammalia TMOD4 34 35
  • 92.75 (n)
mouse
(Mus musculus)
Mammalia Tmod4 34 16 35
  • 90.43 (n)
rat
(Rattus norvegicus)
Mammalia Tmod4 34
  • 89.95 (n)
oppossum
(Monodelphis domestica)
Mammalia TMOD4 35
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMOD4 35
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC100857513 34
  • 72.58 (n)
SKTMOD 35
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMOD4 35
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmod4 34
  • 69.59 (n)
Str.17389 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.24784 34
zebrafish
(Danio rerio)
Actinopterygii tmod4 34 35
  • 68.87 (n)
fruit fly
(Drosophila melanogaster)
Insecta spdo 36
  • 34 (a)
Species where no ortholog for TMOD4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMOD4 Gene

ENSEMBL:
Gene Tree for TMOD4 (if available)
TreeFam:
Gene Tree for TMOD4 (if available)

Paralogs for TMOD4 Gene

Paralogs for TMOD4 Gene

(6) SIMAP similar genes for TMOD4 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with TMOD4: view

Variants for TMOD4 Gene

Sequence variations from dbSNP and Humsavar for TMOD4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000141052 -- 151,175,756(+) ACATC(A/G)ACAAT intron-variant, upstream-variant-2KB
rs1000857135 -- 151,172,158(+) ACTCA(C/T)GCAGC intron-variant
rs1001034876 -- 151,177,837(+) CATCA(C/T)GTCTC intron-variant, upstream-variant-2KB
rs1001373081 -- 151,171,734(+) CGGCA(C/G)TGGCT reference, missense
rs1001465731 -- 151,170,622(+) AGCAC(A/G)GTGGC downstream-variant-500B, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for TMOD4 Gene

Variant ID Type Subtype PubMed ID
dgv2n68 CNV loss 17160897
nsv522840 CNV gain 19592680

Variation tolerance for TMOD4 Gene

Residual Variation Intolerance Score: 78.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.09; 50.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMOD4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMOD4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMOD4 Gene

Disorders for TMOD4 Gene

Relevant External Links for TMOD4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMOD4

No disorders were found for TMOD4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMOD4 Gene

Publications for TMOD4 Gene

  1. Sequencing, expression analysis, and mapping of three unique human tropomodulin genes and their mouse orthologs. (PMID: 10662549) Cox P.R. … Zoghbi H.Y. (Genomics 2000) 2 3 4 22 64
  2. Identification of a novel tropomodulin isoform, skeletal tropomodulin, that caps actin filament pointed ends in fast skeletal muscle. (PMID: 10497209) Almenar-Queralt A. … Fowler V.M. (J. Biol. Chem. 1999) 2 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The N-terminal end of nebulin interacts with tropomodulin at the pointed ends of the thin filaments. (PMID: 11016930) McElhinny A.S. … Gregorio C.C. (J. Biol. Chem. 2001) 3 22 64

Products for TMOD4 Gene

Sources for TMOD4 Gene

Content
Loading form....