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Aliases for TMOD3 Gene

Aliases for TMOD3 Gene

  • Tropomodulin 3 2 3 5
  • Ubiquitous Tropomodulin 2 3 4
  • Tropomodulin 3 (Ubiquitous) 3
  • U-Tmod 4
  • UTMOD 3

External Ids for TMOD3 Gene

Previous GeneCards Identifiers for TMOD3 Gene

  • GC15P047679
  • GC15P045167
  • GC15P049701
  • GC15P049837
  • GC15P049909
  • GC15P052121
  • GC15P028953

Summaries for TMOD3 Gene

GeneCards Summary for TMOD3 Gene

TMOD3 (Tropomodulin 3) is a Protein Coding gene. Among its related pathways are Cardiac conduction and Striated Muscle Contraction. GO annotations related to this gene include actin binding and tropomyosin binding. An important paralog of this gene is LMOD1.

UniProtKB/Swiss-Prot for TMOD3 Gene

  • Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton (By similarity).

Gene Wiki entry for TMOD3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMOD3 Gene

Genomics for TMOD3 Gene

Regulatory Elements for TMOD3 Gene

Enhancers for TMOD3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TMOD3 on UCSC Golden Path with GeneCards custom track

Promoters for TMOD3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TMOD3 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMOD3 Gene

Chromosome:
15
Start:
51,829,628 bp from pter
End:
51,947,295 bp from pter
Size:
117,668 bases
Orientation:
Plus strand

Genomic View for TMOD3 Gene

Genes around TMOD3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMOD3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMOD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMOD3 Gene

Proteins for TMOD3 Gene

  • Protein details for TMOD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NYL9-TMOD3_HUMAN
    Recommended name:
    Tropomodulin-3
    Protein Accession:
    Q9NYL9
    Secondary Accessions:
    • B2R6G7
    • Q9NT43
    • Q9NZR0

    Protein attributes for TMOD3 Gene

    Size:
    352 amino acids
    Molecular mass:
    39595 Da
    Quaternary structure:
    • Binds to the N-terminus of tropomyosin and to actin.

neXtProt entry for TMOD3 Gene

Proteomics data for TMOD3 Gene at MOPED

Post-translational modifications for TMOD3 Gene

  • Ubiquitination at Lys 103 and Lys 172
  • Modification sites at PhosphoSitePlus

Other Protein References for TMOD3 Gene

No data available for DME Specific Peptides for TMOD3 Gene

Domains & Families for TMOD3 Gene

Gene Families for TMOD3 Gene

Protein Domains for TMOD3 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for TMOD3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NYL9

UniProtKB/Swiss-Prot:

TMOD3_HUMAN :
  • Belongs to the tropomodulin family.
Family:
  • Belongs to the tropomodulin family.
genes like me logo Genes that share domains with TMOD3: view

Function for TMOD3 Gene

Molecular function for TMOD3 Gene

GENATLAS Biochemistry:
tropomodulin 3,ubiquitous
UniProtKB/Swiss-Prot Function:
Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton (By similarity).
genes like me logo Genes that share phenotypes with TMOD3: view

Animal Model Products

miRNA for TMOD3 Gene

miRTarBase miRNAs that target TMOD3

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMOD3 Gene

Localization for TMOD3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMOD3 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMOD3 Gene COMPARTMENTS Subcellular localization image for TMOD3 gene
Compartment Confidence
cytoskeleton 4
cytosol 4
nucleus 2

No data available for Gene Ontology (GO) - Cellular Components for TMOD3 Gene

Pathways & Interactions for TMOD3 Gene

genes like me logo Genes that share pathways with TMOD3: view

Pathways by source for TMOD3 Gene

2 Reactome pathways for TMOD3 Gene

Gene Ontology (GO) - Biological Process for TMOD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007015 actin filament organization IBA --
GO:0030036 actin cytoskeleton organization IEA --
GO:0048821 erythrocyte development IEA --
GO:0051694 pointed-end actin filament capping IEA --
genes like me logo Genes that share ontologies with TMOD3: view

No data available for SIGNOR curated interactions for TMOD3 Gene

Drugs & Compounds for TMOD3 Gene

No Compound Related Data Available

Transcripts for TMOD3 Gene

Unigene Clusters for TMOD3 Gene

Tropomodulin 3 (ubiquitous):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMOD3 Gene

No ASD Table

Relevant External Links for TMOD3 Gene

GeneLoc Exon Structure for
TMOD3
ECgene alternative splicing isoforms for
TMOD3

Expression for TMOD3 Gene

mRNA expression in normal human tissues for TMOD3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMOD3 Gene

This gene is overexpressed in Esophagus - Mucosa (x5.0).

Protein differential expression in normal tissues from HIPED for TMOD3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (15.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TMOD3 Gene



SOURCE GeneReport for Unigene cluster for TMOD3 Gene Hs.4998

mRNA Expression by UniProt/SwissProt for TMOD3 Gene

Q9NYL9-TMOD3_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with TMOD3: view

Protein tissue co-expression partners for TMOD3 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for TMOD3 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMOD3 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia TMOD3 35
  • 93.84 (n)
  • 95.17 (a)
TMOD3 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmod3 35
  • 86.65 (n)
  • 90.06 (a)
Tmod3 16
Tmod3 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TMOD3 35
  • 99.53 (n)
  • 99.43 (a)
TMOD3 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmod3 35
  • 86.84 (n)
  • 90.34 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 67 (a)
OneToMany
-- 36
  • 97 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia TMOD3 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMOD3 36
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMOD3 35
  • 79.92 (n)
  • 82.1 (a)
TMOD3 36
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMOD3 36
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmod3 35
  • 71.61 (n)
  • 74.71 (a)
African clawed frog
(Xenopus laevis)
Amphibia tmod3-prov 35
zebrafish
(Danio rerio)
Actinopterygii tmod2 36
  • 73 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta spdo 37
  • 33 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.135 35
Species with no ortholog for TMOD3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMOD3 Gene

ENSEMBL:
Gene Tree for TMOD3 (if available)
TreeFam:
Gene Tree for TMOD3 (if available)

Paralogs for TMOD3 Gene

Paralogs for TMOD3 Gene

(7) SIMAP similar genes for TMOD3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with TMOD3: view

Variants for TMOD3 Gene

Sequence variations from dbSNP and Humsavar for TMOD3 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs11049 -- 51,911,616(+) AGCTT(A/G)TGTGG utr-variant-3-prime
rs5812569 -- 51,828,594(+) CTTGG(-/AAAAAA/AAAAAAA)AAAAA upstream-variant-2KB
rs5812570 -- 51,843,893(+) TTTTT(-/T/TT)AATAG intron-variant
rs5812575 -- 51,905,906(+) CCACT(-/GCAGTCC)GCAGT intron-variant
rs6493525 -- 51,831,619(+) TGATG(A/G)CTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMOD3 Gene

Variant ID Type Subtype PubMed ID
esv270156 CNV Insertion 20981092

Variation tolerance for TMOD3 Gene

Residual Variation Intolerance Score: 36.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.85; 17.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMOD3 Gene

HapMap Linkage Disequilibrium report
TMOD3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMOD3 Gene

Disorders for TMOD3 Gene

Relevant External Links for TMOD3

Genetic Association Database (GAD)
TMOD3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMOD3

No disorders were found for TMOD3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMOD3 Gene

Publications for TMOD3 Gene

  1. Sequencing, expression analysis, and mapping of three unique human tropomodulin genes and their mouse orthologs. (PMID: 10662549) Cox P.R. … Zoghbi H.Y. (Genomics 2000) 2 3 4 23 67
  2. Tropomodulin 3 binds to actin monomers. (PMID: 17012745) Fischer R.S. … Fowler V.M. (J. Biol. Chem. 2006) 3 23
  3. Pointed-end capping by tropomodulin3 negatively regulates endothelial cell motility. (PMID: 12707310) Fischer R.S. … Fowler V.M. (J. Cell Biol. 2003) 3 23
  4. The Dual Estrogen Receptor I+ Inhibitory Effects of the Tissue-Selective Estrogen Complex for Endometrial and Breast Safety. (PMID: 26487511) Han S.J. … O'Malley B.W. (Mol. Pharmacol. 2016) 3
  5. FBXW7 modulates cellular stress response and metastatic potential through a88HSF1 post-translational modification. (PMID: 25720964) Kourtis N. … Aifantis I. (Nat. Cell Biol. 2015) 3

Products for TMOD3 Gene

Sources for TMOD3 Gene

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