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Aliases for TMOD3 Gene

Aliases for TMOD3 Gene

  • Tropomodulin 3 2 3 5
  • Ubiquitous Tropomodulin 2 3 4
  • Tropomodulin 3 (Ubiquitous) 3
  • Tropomodulin-3 3
  • U-Tmod 4
  • UTMOD 3

External Ids for TMOD3 Gene

Previous GeneCards Identifiers for TMOD3 Gene

  • GC15P047679
  • GC15P045167
  • GC15P049701
  • GC15P049837
  • GC15P049909
  • GC15P052121
  • GC15P028953

Summaries for TMOD3 Gene

GeneCards Summary for TMOD3 Gene

TMOD3 (Tropomodulin 3) is a Protein Coding gene. Among its related pathways are Cardiac conduction and Striated Muscle Contraction. GO annotations related to this gene include actin binding and tropomyosin binding. An important paralog of this gene is TMOD2.

UniProtKB/Swiss-Prot for TMOD3 Gene

  • Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton (By similarity).

Gene Wiki entry for TMOD3 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMOD3 Gene

Genomics for TMOD3 Gene

Regulatory Elements for TMOD3 Gene

Enhancers for TMOD3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15G051873 1.4 Ensembl ENCODE dbSUPER 23.8 +45.6 45554 4.3 PKNOX1 SIN3A BRCA1 RFX5 RCOR1 FOS ZHX1 HCFC1 CEBPB ZEB2 LYSMD2 TMOD3 ENSG00000259178 GC15P051886 LOC100422490
GH15G051877 1.4 Ensembl ENCODE dbSUPER 23.8 +49.7 49749 3.7 HDAC1 ARNT RAD21 BRCA1 YY1 TCF12 GATA2 DEK CEBPB NFIC LYSMD2 TMOD3 GNB5 TMOD2 GC15P051886 LOC100422490
GH15G051841 2 FANTOM5 Ensembl ENCODE dbSUPER 13 +15.0 15010 6.9 HDGF PKNOX1 FOXA2 CREB3L1 MLX ARNT ARID4B SIN3A DMAP1 FEZF1 LYSMD2 TMOD2 TMOD3 DMXL2 MAPK6 ENSG00000259178 MYO5C ENSG00000274954 ENSG00000277677
GH15G051861 1.1 FANTOM5 ENCODE dbSUPER 23.6 +32.3 32349 1.5 SMARCA4 ZMYM3 MAX TMOD3 LYSMD2 LOC100422490 GC15P051886
GH15G051862 1.1 ENCODE dbSUPER 21.8 +34.7 34718 2.9 ELF3 RAD21 YY1 RARA THAP11 CEBPB PPARG NR2F2 MEF2D CEBPA LYSMD2 TMOD3 LOC100422556 LOC100422490 GC15P051886
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMOD3 on UCSC Golden Path with GeneCards custom track

Promoters for TMOD3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000076626 772 2001 HDGF PKNOX1 MLX CREB3L1 ARNT WRNIP1 ARID4B SIN3A DMAP1 YY1

Genomic Location for TMOD3 Gene

Chromosome:
15
Start:
51,829,628 bp from pter
End:
51,947,295 bp from pter
Size:
117,668 bases
Orientation:
Plus strand

Genomic View for TMOD3 Gene

Genes around TMOD3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMOD3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMOD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMOD3 Gene

Proteins for TMOD3 Gene

  • Protein details for TMOD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NYL9-TMOD3_HUMAN
    Recommended name:
    Tropomodulin-3
    Protein Accession:
    Q9NYL9
    Secondary Accessions:
    • B2R6G7
    • Q9NT43
    • Q9NZR0

    Protein attributes for TMOD3 Gene

    Size:
    352 amino acids
    Molecular mass:
    39595 Da
    Quaternary structure:
    • Binds to the N-terminus of tropomyosin and to actin.

neXtProt entry for TMOD3 Gene

Post-translational modifications for TMOD3 Gene

  • Ubiquitination at Lys103 and Lys172
  • Modification sites at PhosphoSitePlus

Other Protein References for TMOD3 Gene

No data available for DME Specific Peptides for TMOD3 Gene

Domains & Families for TMOD3 Gene

Gene Families for TMOD3 Gene

Protein Domains for TMOD3 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for TMOD3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NYL9

UniProtKB/Swiss-Prot:

TMOD3_HUMAN :
  • Belongs to the tropomodulin family.
Family:
  • Belongs to the tropomodulin family.
genes like me logo Genes that share domains with TMOD3: view

Function for TMOD3 Gene

Molecular function for TMOD3 Gene

GENATLAS Biochemistry:
tropomodulin 3,ubiquitous
UniProtKB/Swiss-Prot Function:
Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton (By similarity).

Gene Ontology (GO) - Molecular Function for TMOD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0005523 tropomyosin binding IEA --
GO:0098641 cadherin binding involved in cell-cell adhesion IDA 25468996
genes like me logo Genes that share ontologies with TMOD3: view
genes like me logo Genes that share phenotypes with TMOD3: view

Animal Model Products

miRNA for TMOD3 Gene

miRTarBase miRNAs that target TMOD3

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMOD3 Gene

Localization for TMOD3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMOD3 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMOD3 gene
Compartment Confidence
cytoskeleton 4
cytosol 4
nucleus 2

Gene Ontology (GO) - Cellular Components for TMOD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0005865 striated muscle thin filament IEA --
GO:0005913 cell-cell adherens junction IDA 25468996
genes like me logo Genes that share ontologies with TMOD3: view

Pathways & Interactions for TMOD3 Gene

genes like me logo Genes that share pathways with TMOD3: view

Pathways by source for TMOD3 Gene

1 Sino Biological pathway for TMOD3 Gene
2 Reactome pathways for TMOD3 Gene

Gene Ontology (GO) - Biological Process for TMOD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030036 actin cytoskeleton organization IEA --
GO:0048821 erythrocyte development IEA --
GO:0051694 pointed-end actin filament capping IEA --
GO:0098609 cell-cell adhesion IEA --
GO:1901992 positive regulation of mitotic cell cycle phase transition IEA --
genes like me logo Genes that share ontologies with TMOD3: view

No data available for SIGNOR curated interactions for TMOD3 Gene

Drugs & Compounds for TMOD3 Gene

No Compound Related Data Available

Transcripts for TMOD3 Gene

Unigene Clusters for TMOD3 Gene

Tropomodulin 3 (ubiquitous):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMOD3 Gene

No ASD Table

Relevant External Links for TMOD3 Gene

GeneLoc Exon Structure for
TMOD3
ECgene alternative splicing isoforms for
TMOD3

Expression for TMOD3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMOD3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMOD3 Gene

This gene is overexpressed in Esophagus - Mucosa (x5.0).

Protein differential expression in normal tissues from HIPED for TMOD3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (15.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TMOD3 Gene



Protein tissue co-expression partners for TMOD3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TMOD3 Gene:

TMOD3

SOURCE GeneReport for Unigene cluster for TMOD3 Gene:

Hs.4998

mRNA Expression by UniProt/SwissProt for TMOD3 Gene:

Q9NYL9-TMOD3_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for TMOD3 Gene

  • Liver(4.3)
  • Nervous system(4.3)
  • Adrenal gland(4.2)
genes like me logo Genes that share expression patterns with TMOD3: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for TMOD3 Gene

Orthologs for TMOD3 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMOD3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMOD3 34 35
  • 99.53 (n)
cow
(Bos Taurus)
Mammalia -- 35
  • 97 (a)
OneToMany
-- 35
  • 67 (a)
OneToMany
dog
(Canis familiaris)
Mammalia TMOD3 34 35
  • 93.84 (n)
oppossum
(Monodelphis domestica)
Mammalia TMOD3 35
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMOD3 35
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmod3 34
  • 86.84 (n)
mouse
(Mus musculus)
Mammalia Tmod3 34 16 35
  • 86.65 (n)
chicken
(Gallus gallus)
Aves TMOD3 34 35
  • 79.92 (n)
lizard
(Anolis carolinensis)
Reptilia TMOD3 35
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmod3 34
  • 71.61 (n)
African clawed frog
(Xenopus laevis)
Amphibia tmod3-prov 34
zebrafish
(Danio rerio)
Actinopterygii tmod2 35
  • 73 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta spdo 36
  • 33 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.135 34
Species where no ortholog for TMOD3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMOD3 Gene

ENSEMBL:
Gene Tree for TMOD3 (if available)
TreeFam:
Gene Tree for TMOD3 (if available)

Paralogs for TMOD3 Gene

Paralogs for TMOD3 Gene

(7) SIMAP similar genes for TMOD3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with TMOD3: view

Variants for TMOD3 Gene

Sequence variations from dbSNP and Humsavar for TMOD3 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1000063084 -- 51,862,492(+) AAGCT(A/G)TTGAT intron-variant
rs1000074884 -- 51,832,575(+) TTCTG(G/T)GGTAC intron-variant
rs1000087447 -- 51,909,772(+) CATGT(A/G)TGTAA utr-variant-3-prime
rs1000092852 -- 51,892,312(+) CCACA(A/G)AAAAG intron-variant
rs1000118425 -- 51,877,156(+) TGCCA(A/G)TTTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMOD3 Gene

Variant ID Type Subtype PubMed ID
esv3305879 CNV mobile element insertion 20981092
esv3405176 CNV insertion 20981092
nsv473281 CNV novel sequence insertion 20440878
nsv569409 CNV loss 21841781
nsv952626 CNV duplication 24416366

Variation tolerance for TMOD3 Gene

Residual Variation Intolerance Score: 36.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.85; 17.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMOD3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMOD3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMOD3 Gene

Disorders for TMOD3 Gene

Relevant External Links for TMOD3

Genetic Association Database (GAD)
TMOD3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMOD3

No disorders were found for TMOD3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMOD3 Gene

Publications for TMOD3 Gene

  1. Sequencing, expression analysis, and mapping of three unique human tropomodulin genes and their mouse orthologs. (PMID: 10662549) Cox P.R. … Zoghbi H.Y. (Genomics 2000) 2 3 4 22 64
  2. Tropomodulin 3 binds to actin monomers. (PMID: 17012745) Fischer R.S. … Fowler V.M. (J. Biol. Chem. 2006) 3 22 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Pointed-end capping by tropomodulin3 negatively regulates endothelial cell motility. (PMID: 12707310) Fischer R.S. … Fowler V.M. (J. Cell Biol. 2003) 3 22 64
  5. The Dual Estrogen Receptor I+ Inhibitory Effects of the Tissue-Selective Estrogen Complex for Endometrial and Breast Safety. (PMID: 26487511) Han S.J. … O'Malley B.W. (Mol. Pharmacol. 2016) 3 64

Products for TMOD3 Gene

Sources for TMOD3 Gene

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