Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TMOD3 Gene

Aliases for TMOD3 Gene

  • Tropomodulin 3 2 3 5
  • Ubiquitous Tropomodulin 2 3 4
  • Tropomodulin 3 (Ubiquitous) 3
  • Tropomodulin-3 3
  • U-Tmod 4
  • UTMOD 3

External Ids for TMOD3 Gene

Previous GeneCards Identifiers for TMOD3 Gene

  • GC15P047679
  • GC15P045167
  • GC15P049701
  • GC15P049837
  • GC15P049909
  • GC15P052121
  • GC15P028953

Summaries for TMOD3 Gene

GeneCards Summary for TMOD3 Gene

TMOD3 (Tropomodulin 3) is a Protein Coding gene. Among its related pathways are Cardiac conduction and Striated Muscle Contraction. Gene Ontology (GO) annotations related to this gene include actin binding and tropomyosin binding. An important paralog of this gene is TMOD2.

UniProtKB/Swiss-Prot for TMOD3 Gene

  • Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton (By similarity).

Gene Wiki entry for TMOD3 Gene

Additional gene information for TMOD3 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMOD3 Gene

Genomics for TMOD3 Gene

GeneHancer (GH) Regulatory Elements for TMOD3 Gene

Promoters and enhancers for TMOD3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15I051828 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 558.6 +0.4 405 4 HDGF PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 YY1 POLR2B ZNF766 TMOD3 LYSMD2 LOC100422556 DMXL2 GNB5 ENSG00000274954
GH15I051873 Enhancer 1.3 Ensembl ENCODE dbSUPER 23.8 +45.6 45553 4.3 PKNOX1 NEUROD1 SIN3A BRCA1 RFX5 FOS RCOR1 HCFC1 RXRA CEBPB LYSMD2 TMOD3 AP4E1 ENSG00000259178 GC15P051886 LOC100422490
GH15I051877 Enhancer 1.2 Ensembl ENCODE dbSUPER 23.8 +49.7 49748 3.7 HDAC1 ARNT BRCA1 ZBTB40 YY1 TCF12 DEK NCOA1 CEBPB SP1 LYSMD2 TMOD3 GNB5 TMOD2 GC15P051886 LOC100422490 GC15M057424
GH15I051728 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 8.2 -95.8 -95752 9.9 PKNOX1 ATF1 SIN3A IRF4 YY1 ZNF766 GLIS2 ELK1 ZNF207 ZNF143 LYSMD2 DMXL2 SCG3 TMOD3 MAPK6 TMOD2 ENSG00000259296
GH15I051841 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 13 +15.0 15010 6.9 PKNOX1 SMAD1 ATF1 SIN3A FEZF1 BRCA1 ZNF766 ATF7 FOS RUNX3 LYSMD2 TMOD2 TMOD3 DMXL2 MAPK6 ENSG00000259178 MYO5C ENSG00000274954 ENSG00000277677
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TMOD3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TMOD3 gene promoter:

Genomic Locations for TMOD3 Gene

Genomic Locations for TMOD3 Gene
chr15:51,829,628-51,947,295
(GRCh38/hg38)
Size:
117,668 bases
Orientation:
Plus strand
chr15:52,121,825-52,239,492
(GRCh37/hg19)

Genomic View for TMOD3 Gene

Genes around TMOD3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMOD3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMOD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMOD3 Gene

Proteins for TMOD3 Gene

  • Protein details for TMOD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NYL9-TMOD3_HUMAN
    Recommended name:
    Tropomodulin-3
    Protein Accession:
    Q9NYL9
    Secondary Accessions:
    • B2R6G7
    • Q9NT43
    • Q9NZR0

    Protein attributes for TMOD3 Gene

    Size:
    352 amino acids
    Molecular mass:
    39595 Da
    Quaternary structure:
    • Binds to the N-terminus of tropomyosin and to actin.

neXtProt entry for TMOD3 Gene

Post-translational modifications for TMOD3 Gene

  • Ubiquitination at posLast=103103 and isoforms=172

Other Protein References for TMOD3 Gene

No data available for DME Specific Peptides for TMOD3 Gene

Domains & Families for TMOD3 Gene

Gene Families for TMOD3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for TMOD3 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for TMOD3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NYL9

UniProtKB/Swiss-Prot:

TMOD3_HUMAN :
  • Belongs to the tropomodulin family.
Family:
  • Belongs to the tropomodulin family.
genes like me logo Genes that share domains with TMOD3: view

Function for TMOD3 Gene

Molecular function for TMOD3 Gene

GENATLAS Biochemistry:
tropomodulin 3,ubiquitous
UniProtKB/Swiss-Prot Function:
Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton (By similarity).

Gene Ontology (GO) - Molecular Function for TMOD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0005523 tropomyosin binding IEA,IBA --
GO:0098641 cadherin binding involved in cell-cell adhesion IDA 25468996
genes like me logo Genes that share ontologies with TMOD3: view
genes like me logo Genes that share phenotypes with TMOD3: view

Animal Model Products

miRNA for TMOD3 Gene

miRTarBase miRNAs that target TMOD3

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMOD3 Gene

Localization for TMOD3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMOD3 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMOD3 gene
Compartment Confidence
cytoskeleton 4
cytosol 4
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Actin filaments (2)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TMOD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0005865 striated muscle thin filament IEA,IBA --
GO:0005913 cell-cell adherens junction IDA 25468996
genes like me logo Genes that share ontologies with TMOD3: view

Pathways & Interactions for TMOD3 Gene

genes like me logo Genes that share pathways with TMOD3: view

Pathways by source for TMOD3 Gene

1 Sino Biological pathway for TMOD3 Gene
2 Reactome pathways for TMOD3 Gene

Gene Ontology (GO) - Biological Process for TMOD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006936 muscle contraction IBA --
GO:0007015 actin filament organization IBA --
GO:0030036 actin cytoskeleton organization IEA --
GO:0030239 myofibril assembly IBA --
GO:0048821 erythrocyte development IEA --
genes like me logo Genes that share ontologies with TMOD3: view

No data available for SIGNOR curated interactions for TMOD3 Gene

Drugs & Compounds for TMOD3 Gene

No Compound Related Data Available

Transcripts for TMOD3 Gene

Unigene Clusters for TMOD3 Gene

Tropomodulin 3 (ubiquitous):
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMOD3 Gene

No ASD Table

Relevant External Links for TMOD3 Gene

GeneLoc Exon Structure for
TMOD3
ECgene alternative splicing isoforms for
TMOD3

Expression for TMOD3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMOD3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMOD3 Gene

This gene is overexpressed in Esophagus - Mucosa (x5.0).

Protein differential expression in normal tissues from HIPED for TMOD3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (15.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TMOD3 Gene



Protein tissue co-expression partners for TMOD3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TMOD3 Gene:

TMOD3

SOURCE GeneReport for Unigene cluster for TMOD3 Gene:

Hs.4998

mRNA Expression by UniProt/SwissProt for TMOD3 Gene:

Q9NYL9-TMOD3_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for TMOD3 Gene

  • Liver(4.3)
  • Nervous system(4.3)
  • Adrenal gland(4.2)
genes like me logo Genes that share expression patterns with TMOD3: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for TMOD3 Gene

Orthologs for TMOD3 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMOD3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMOD3 33 34
  • 99.53 (n)
cow
(Bos Taurus)
Mammalia -- 34
  • 97 (a)
OneToMany
-- 34
  • 67 (a)
OneToMany
dog
(Canis familiaris)
Mammalia TMOD3 33 34
  • 93.84 (n)
oppossum
(Monodelphis domestica)
Mammalia TMOD3 34
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMOD3 34
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmod3 33
  • 86.84 (n)
mouse
(Mus musculus)
Mammalia Tmod3 33 16 34
  • 86.65 (n)
chicken
(Gallus gallus)
Aves TMOD3 33 34
  • 79.92 (n)
lizard
(Anolis carolinensis)
Reptilia TMOD3 34
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmod3 33
  • 71.61 (n)
African clawed frog
(Xenopus laevis)
Amphibia tmod3-prov 33
zebrafish
(Danio rerio)
Actinopterygii tmod2 34
  • 73 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta spdo 35
  • 33 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.135 33
Species where no ortholog for TMOD3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMOD3 Gene

ENSEMBL:
Gene Tree for TMOD3 (if available)
TreeFam:
Gene Tree for TMOD3 (if available)

Paralogs for TMOD3 Gene

Paralogs for TMOD3 Gene

(7) SIMAP similar genes for TMOD3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with TMOD3: view

Variants for TMOD3 Gene

Sequence variations from dbSNP and Humsavar for TMOD3 Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1000063084 -- 51,862,492(+) A/G intron_variant
rs1000074884 -- 51,832,575(+) T/G genic_upstream_transcript_variant, intron_variant
rs1000087447 -- 51,909,772(+) A/G 3_prime_UTR_variant
rs1000092852 -- 51,892,312(+) A/G intron_variant
rs1000118425 -- 51,877,156(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TMOD3 Gene

Variant ID Type Subtype PubMed ID
esv3305879 CNV mobile element insertion 20981092
esv3405176 CNV insertion 20981092
nsv473281 CNV novel sequence insertion 20440878
nsv569409 CNV loss 21841781
nsv952626 CNV duplication 24416366

Variation tolerance for TMOD3 Gene

Residual Variation Intolerance Score: 36.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.85; 17.71% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMOD3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMOD3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMOD3 Gene

Disorders for TMOD3 Gene

Additional Disease Information for TMOD3

No disorders were found for TMOD3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMOD3 Gene

Publications for TMOD3 Gene

  1. Sequencing, expression analysis, and mapping of three unique human tropomodulin genes and their mouse orthologs. (PMID: 10662549) Cox PR … Zoghbi HY (Genomics 2000) 2 3 4 22 58
  2. Tropomodulin 3 binds to actin monomers. (PMID: 17012745) Fischer RS … Fowler VM (The Journal of biological chemistry 2006) 3 22 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Pointed-end capping by tropomodulin3 negatively regulates endothelial cell motility. (PMID: 12707310) Fischer RS … Fowler VM (The Journal of cell biology 2003) 3 22 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for TMOD3 Gene

Sources for TMOD3 Gene

Content
Loading form....