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TMOD2 Gene

protein-coding   GIFtS: 55
GCID: GC15P052043

Tropomodulin 2 (Neuronal)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tropomodulin 2 (Neuronal)1 2
Neuronal Tropomodulin2 3
NTMOD2 3
N-TMOD2
tropomodulin-22
N-Tmod3

External Ids:    HGNC: 118721   Entrez Gene: 297672   Ensembl: ENSG000001288727   OMIM: 6029285   UniProtKB: Q9NZR13   

Export aliases for TMOD2 gene to outside databases

Previous GC identifers: GC15P047601 GC15P045089 GC15P049622 GC15P049759 GC15P049831 GC15P028878


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TMOD2 Gene:
This gene encodes a neuronal-specific member of the tropomodulin family of actin-regulatory proteins. The encoded
protein caps the pointed end of actin filaments preventing both elongation and depolymerization. The capping
activity of this protein is dependent on its association with tropomyosin. Alternatively spliced transcript
variants encoding different isoforms have been described. (provided by RefSeq, Dec 2008)

GeneCards Summary for TMOD2 Gene:
TMOD2 (tropomodulin 2 (neuronal)) is a protein-coding gene. Diseases associated with TMOD2 include neuronitis, and temporal lobe epilepsy. GO annotations related to this gene include actin binding and tropomyosin binding. An important paralog of this gene is TMOD1.

UniProtKB/Swiss-Prot: TMOD2_HUMAN, Q9NZR1
Function: Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM
complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the
membrane skeleton (By similarity)

Gene Wiki entry for TMOD2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000015.10  NC_018926.2  NT_010194.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the TMOD2 gene promoter:
         AML1a   Lmo2   NF-kappaB   HNF-1A   Roaz   Pax-3   c-Rel   HNF-1   Cart-1   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMOD2 promoter sequence
   Search Chromatin IP Primers for TMOD2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TMOD2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q21.2   Ensembl cytogenetic band:  15q21.2   HGNC cytogenetic band: 15q21.2

TMOD2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMOD2 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P052043:  view genomic region     (about GC identifiers)

Start:
52,043,758 bp from pter      End:
52,108,565 bp from pter
Size:
64,808 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TMOD2_HUMAN, Q9NZR1 (See protein sequence)
Recommended Name: Tropomodulin-2  
Size: 351 amino acids; 39595 Da
Subunit: Binds to the N-terminus of tropomyosin and to actin
Secondary accessions: B4DEW6
Alternative splicing: 2 isoforms:  Q9NZR1-1   Q9NZR1-2   

Explore the universe of human proteins at neXtProt for TMOD2: NX_Q9NZR1

Explore proteomics data for TMOD2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TMOD2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001136357.1  NP_055363.1  

    ENSEMBL proteins: 
     ENSP00000249700   ENSP00000437743   ENSP00000404590   ENSP00000453524  

    TMOD2 Human Recombinant Protein Products:

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    Novus Biologicals TMOD2 Protein
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    Cloud-Clone Corp. Proteins for TMOD2

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    Cloud-Clone Corp. CLIAs for TMOD2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR004934 Tropomodulin

    Graphical View of Domain Structure for InterPro Entry Q9NZR1

    ProtoNet protein and cluster: Q9NZR1

    1 Blocks protein domain: IPB004934 Tropomodulin

    UniProtKB/Swiss-Prot: TMOD2_HUMAN, Q9NZR1
    Similarity: Belongs to the tropomodulin family


    TMOD2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TMOD2_HUMAN, Q9NZR1
    Function: Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM
    complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the
    membrane skeleton (By similarity)

         Genatlas biochemistry entry for TMOD2:
    tropomodulin 2,neuronal

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
    GO:0005523tropomyosin binding IEA--
         
    TMOD2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for TMOD2:
     Increased HPV18 LCR reporter a 

         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Tmod2):
     behavior/neurological  nervous system 

    TMOD2 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TMOD2
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TMOD2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TMOD2

    miRNA
    Products:
        
    miRTarBase miRNAs that target TMOD2:
    hsa-mir-484 (MIRT041699), hsa-mir-34a-5p (MIRT025435), hsa-mir-335-5p (MIRT018829)

    Block miRNA regulation of human, mouse, rat TMOD2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TMOD2 (see all 115):
    hsa-miR-3938 hsa-miR-376b hsa-miR-485-3p hsa-miR-219-5p hsa-miR-30d hsa-miR-3142 hsa-miR-30a hsa-miR-629*
    SwitchGear 3'UTR luciferase reporter plasmidTMOD2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TMOD2

    Gene Editing
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    OriGene ORF clones in mouse, rat for TMOD2
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    GenScript: all cDNA clones in your preferred vector (see all 2): TMOD2 (NM_014548)
    Sino Biological Human cDNA Clone for TMOD2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMOD2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMOD2

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    Browse ESI BIO Cell Lines and PureStem Progenitors for TMOD2 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMOD2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TMOD2_HUMAN, Q9NZR1: Cytoplasm, cytoskeleton (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton2
    cytosol2
    nucleus2

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005856cytoskeleton IEA--
    GO:0030426growth cone IEA--
    GO:0043005neuron projection ----

    TMOD2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TMOD2
    Interactions:

        Search GeneGlobe Interaction Network for TMOD2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    Selected Interacting proteins for TMOD2 (Q9NZR13 ENSP000002497004) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TPM1P094933, ENSP000002679964I2D: score=1 STRING: ENSP00000267996
    DLG4P783523I2D: score=1 
    TPM3P067533I2D: score=1 
    YWHABP319463I2D: score=1 
    LCMT1ENSP000003820214STRING: ENSP00000382021
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007270neuron-neuron synaptic transmission IEA--
    GO:0007399nervous system development TAS10662549
    GO:0007611learning or memory IEA--
    GO:0045745positive regulation of G-protein coupled receptor protein signaling pathway IEA--

    TMOD2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TMOD2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TMOD2 gene (2 alternative transcripts): 
    NM_001142885.1  NM_014548.3  

    Unigene Cluster for TMOD2:

    Tropomodulin 2 (neuronal)
    Hs.513734  [show with all ESTs]
    Unigene Representative Sequence: NM_014548
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000249700(uc002abk.3 uc002abl.4 uc010bfb.3) ENST00000539962
    ENST00000560576 ENST00000435126 ENST00000561300 ENST00000561407
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TMOD2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TMOD2 (see all 115):
    hsa-miR-3938 hsa-miR-376b hsa-miR-485-3p hsa-miR-219-5p hsa-miR-30d hsa-miR-3142 hsa-miR-30a hsa-miR-629*
    SwitchGear 3'UTR luciferase reporter plasmidTMOD2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TMOD2
    Predesigned siRNA for gene silencing in human, mouse, rat TMOD2
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    OriGene ORF clones in mouse, rat for TMOD2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TMOD2 (NM_014548)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMOD2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMOD2
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TMOD2
    OriGene qSTAR qPCR primer pairs in human, mouse for TMOD2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TMOD2
      QuantiTect SYBR Green Assays in human, mouse, rat TMOD2
      QuantiFast Probe-based Assays in human, mouse, rat TMOD2

    Additional mRNA sequence: 

    AB073658.1 AF177169.1 AK021496.1 AK025346.1 AK124907.1 AK292733.1 AK293823.1 BC036184.1 
    BC041940.1 BC052749.1 BC064961.1 

    6 DOTS entries:

    DT.70105254  DT.40286829  DT.95261750  DT.40279240  DT.95077606  DT.121081180 

    Selected AceView cDNA sequences (see all 108):

    BE468147 BX493530 BF447564 AI634227 CA442590 N92161 AI696912 BG704541 
    CA391841 AI623265 BU539449 AA970254 AL712591 AA455058 BI711824 AK124907 
    BE468139 AK025346 AA576359 AW207699 AI802079 AL707504 CA391842 AW469929 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for TMOD2    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b
    SP1:              -                                                               
    SP2:              -     -                                                         
    SP3:                                                                              


    ECgene alternative splicing isoforms for TMOD2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TMOD2 expression in normal human tissues (normalized intensities)      TMOD2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCACTAATCT
    TMOD2 Expression
    About this image


    TMOD2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Blood (Cardiovascular System)
             Conventional Dendritic Cells II Spleen
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Spleen (Hematopoietic System)
             Conventional Dendritic Cells II Spleen
    TMOD2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TMOD2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.513734

    UniProtKB/Swiss-Prot: TMOD2_HUMAN, Q9NZR1
    Tissue specificity: Neuronal-tissue specific

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMOD2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TMOD2 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tmod21 , 5 tropomodulin 21, 5 90.03(n)1
    95.16(a)1
      9 (42.31 cM)5
    508761  NM_001038710.11  NP_001033799.11 
     755656215 
    chicken
    (Gallus gallus)
    Aves TMOD21 tropomodulin 2 (neuronal) 78.82(n)
    86.32(a)
      415422  XM_413805.4  XP_413805.1 
    lizard
    (Anolis carolinensis)
    Reptilia TMOD26
    tropomodulin 2 (neuronal)
    86(a)
    1 ↔ 1
    GL343330.1(737789-751367)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia tmod21 tropomodulin 2 (neuronal) 73.12(n)
    75.5(a)
      100127704  NM_001113042.1  NP_001106513.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tmod21 tropomodulin 2 71.33(n)
    74.05(a)
      447869  NM_001004608.1  NP_001004608.1 


    ENSEMBL Gene Tree for TMOD2 (if available)
    TreeFam Gene Tree for TMOD2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TMOD2 gene
    TMOD12  LMOD32  TMOD42  LMOD22  TMOD32  LMOD12  
    8 SIMAP similar genes for TMOD2 using alignment to 4 protein entries:     TMOD2_HUMAN (see all proteins):
    DKFZp686E1899    TMOD3    TMOD1    TMOD4    LMOD2    NLRC3
    LMOD3    LMOD1

    TMOD2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TMOD2 (see all 1290)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs30781331,2
    C--32116368(+) gtctc-/AA/AAA
            
    aaaaa
    2 -- int12NA 4
    rs740157581,2
    C,F--52045749(+) AAAAAA/CAAAAG 2 -- int12Minor allele frequency- C:0.07WA 120
    rs740157591,2
    C,F--52045803(+) GATTGC/TATGTT 2 -- int11Minor allele frequency- T:0.50WA 2
    rs755503501,2
    --52045955(+) TGTCAG/AAAAAA 2 -- int11Minor allele frequency- A:0.50NA 2
    rs1494961461,2
    C--52045974(+) AGGAT-/AGGGGT 2 -- int10--------
    rs1387300861,2
    --52045996(+) TTCAGA/GAACGT 2 -- int10--------
    rs761350841,2
    C--52046028(+) ACGGTC/TGGTGA 2 -- int10--------
    rs71621761,2
    C,F,A--52046156(+) AGACGG/AGGGTG 2 -- int19Minor allele frequency- A:0.39NA WA CSA EA 370
    rs740157601,2
    C,F--52046209(+) GGCTTC/TACCTT 2 -- int11Minor allele frequency- T:0.50WA 2
    rs768123761,2
    C,F--52046249(+) TGAGTG/TGGGGG 2 -- int12Minor allele frequency- T:0.28NA EA 240

    HapMap Linkage Disequilibrium report for TMOD2 (52043758 - 52108565 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TMOD2: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TMOD2
    DNA2.0 Custom Variant and Variant Library Synthesis for TMOD2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602928    OMIM disorders: --

    8 diseases for TMOD2:    About MalaCards
    neuronitis    temporal lobe epilepsy    lateral sclerosis    amyotrophic lateral sclerosis
    transitional cell carcinoma    ischemia    cerebritis    endotheliitis


    TMOD2 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for TMOD2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    amyotrophic lateral sclerosis 51.8 3 10662549 (1), 11716785 (1)

    Genetic Association Database (GAD): TMOD2

    Export disorders for TMOD2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TMOD2 gene, integrated from 10 sources (see all 20):
    (articles sorted by number of sources associating them with TMOD2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sequencing, expression analysis, and mapping of three unique human tropomodulin genes and their mouse orthologs. (PubMed id 10662549)1, 2, 3, 9 Cox P.R. and Zoghbi H.Y. (Genomics 2000)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. The P-body component USP52/PAN2 is a novel regulator of HIF1A mRNA stability. (PubMed id 23398456)1 Bett J.S....Hay R.T. (Biochem. J. 2013)
    5. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    6. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    7. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PubMed id 17903299)4 Kathiresan S....Cupples L.A. (BMC Med. Genet. 2007)
    8. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)
    9. Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study. (PubMed id 17903301)4 Vasan R.S....Benjamin E.J. (BMC Med. Genet. 2007)
    10. Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness. (PubMed id 17903302)4 Levy D....Mitchell G.F. (BMC Med. Genet. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Aliases
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    OMIM
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 29767 HGNC: 11872 AceView: TMOD2 Ensembl:ENSG00000128872 euGenes: HUgn29767
    ECgene: TMOD2 H-InvDB: TMOD2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TMOD2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TMOD2 gene:
    Search GeneIP for patents involving TMOD2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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