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Aliases for TMOD2 Gene

Aliases for TMOD2 Gene

  • Tropomodulin 2 2 3 5
  • Neuronal Tropomodulin 2 3 4
  • N-TMOD 3 4
  • NTMOD 3 4
  • Tropomodulin 2 (Neuronal) 3

External Ids for TMOD2 Gene

Previous GeneCards Identifiers for TMOD2 Gene

  • GC15P047601
  • GC15P045089
  • GC15P049622
  • GC15P049759
  • GC15P049831
  • GC15P052043
  • GC15P028878

Summaries for TMOD2 Gene

Entrez Gene Summary for TMOD2 Gene

  • This gene encodes a neuronal-specific member of the tropomodulin family of actin-regulatory proteins. The encoded protein caps the pointed end of actin filaments preventing both elongation and depolymerization. The capping activity of this protein is dependent on its association with tropomyosin. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Dec 2008]

GeneCards Summary for TMOD2 Gene

TMOD2 (Tropomodulin 2) is a Protein Coding gene. Diseases associated with TMOD2 include Amyotrophic Lateral Sclerosis 1. Among its related pathways are Striated Muscle Contraction and Cardiac conduction. GO annotations related to this gene include actin binding and tropomyosin binding. An important paralog of this gene is LMOD1.

UniProtKB/Swiss-Prot for TMOD2 Gene

  • Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton (By similarity).

Gene Wiki entry for TMOD2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMOD2 Gene

Genomics for TMOD2 Gene

Regulatory Elements for TMOD2 Gene

Enhancers for TMOD2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TMOD2 on UCSC Golden Path with GeneCards custom track

Promoters for TMOD2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TMOD2 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMOD2 Gene

Chromosome:
15
Start:
51,751,561 bp from pter
End:
51,816,368 bp from pter
Size:
64,808 bases
Orientation:
Plus strand

Genomic View for TMOD2 Gene

Genes around TMOD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMOD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMOD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMOD2 Gene

Proteins for TMOD2 Gene

  • Protein details for TMOD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NZR1-TMOD2_HUMAN
    Recommended name:
    Tropomodulin-2
    Protein Accession:
    Q9NZR1
    Secondary Accessions:
    • B4DEW6

    Protein attributes for TMOD2 Gene

    Size:
    351 amino acids
    Molecular mass:
    39595 Da
    Quaternary structure:
    • Binds to the N-terminus of tropomyosin and to actin.

    Alternative splice isoforms for TMOD2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMOD2 Gene

Proteomics data for TMOD2 Gene at MOPED

Post-translational modifications for TMOD2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMOD2 Gene

Antibody Products

No data available for DME Specific Peptides for TMOD2 Gene

Domains & Families for TMOD2 Gene

Gene Families for TMOD2 Gene

Protein Domains for TMOD2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for TMOD2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NZR1

UniProtKB/Swiss-Prot:

TMOD2_HUMAN :
  • Belongs to the tropomodulin family.
Family:
  • Belongs to the tropomodulin family.
genes like me logo Genes that share domains with TMOD2: view

Function for TMOD2 Gene

Molecular function for TMOD2 Gene

GENATLAS Biochemistry:
tropomodulin 2,neuronal
UniProtKB/Swiss-Prot Function:
Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton (By similarity).
genes like me logo Genes that share phenotypes with TMOD2: view

Animal Models for TMOD2 Gene

MGI Knock Outs for TMOD2:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TMOD2 Gene

Localization for TMOD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMOD2 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMOD2 Gene COMPARTMENTS Subcellular localization image for TMOD2 gene
Compartment Confidence
cytoskeleton 4
nucleus 3
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for TMOD2 Gene

Pathways & Interactions for TMOD2 Gene

genes like me logo Genes that share pathways with TMOD2: view

Pathways by source for TMOD2 Gene

2 Reactome pathways for TMOD2 Gene

Gene Ontology (GO) - Biological Process for TMOD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007015 actin filament organization IBA --
GO:0007399 nervous system development TAS 10662549
GO:0051694 pointed-end actin filament capping IEA --
genes like me logo Genes that share ontologies with TMOD2: view

No data available for SIGNOR curated interactions for TMOD2 Gene

Drugs & Compounds for TMOD2 Gene

No Compound Related Data Available

Transcripts for TMOD2 Gene

Unigene Clusters for TMOD2 Gene

Tropomodulin 2 (neuronal):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMOD2 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b
SP1: -
SP2: - -
SP3:

Relevant External Links for TMOD2 Gene

GeneLoc Exon Structure for
TMOD2
ECgene alternative splicing isoforms for
TMOD2

Expression for TMOD2 Gene

mRNA expression in normal human tissues for TMOD2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMOD2 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x5.1), Brain - Anterior cingulate cortex (BA24) (x4.6), and Brain - Cortex (x4.1).

Protein differential expression in normal tissues from HIPED for TMOD2 Gene

This gene is overexpressed in Brain (44.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TMOD2 Gene



SOURCE GeneReport for Unigene cluster for TMOD2 Gene Hs.513734

mRNA Expression by UniProt/SwissProt for TMOD2 Gene

Q9NZR1-TMOD2_HUMAN
Tissue specificity: Neuronal-tissue specific.
genes like me logo Genes that share expression patterns with TMOD2: view

Primer Products

No data available for Protein tissue co-expression partners for TMOD2 Gene

Orthologs for TMOD2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMOD2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TMOD2 35
  • 93.16 (n)
  • 97.15 (a)
TMOD2 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMOD2 35
  • 92.12 (n)
  • 96.01 (a)
TMOD2 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmod2 35
  • 90.03 (n)
  • 95.16 (a)
Tmod2 16
Tmod2 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TMOD2 35
  • 99.62 (n)
  • 99.72 (a)
TMOD2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmod2 35
  • 88.79 (n)
  • 94.87 (a)
oppossum
(Monodelphis domestica)
Mammalia TMOD2 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMOD2 36
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMOD2 35
  • 78.82 (n)
  • 86.32 (a)
TMOD2 36
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMOD2 36
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmod2 35
  • 73.12 (n)
  • 75.5 (a)
zebrafish
(Danio rerio)
Actinopterygii tmod2 35
  • 71.33 (n)
  • 74.05 (a)
tmod2 36
  • 74 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.683 35
fruit fly
(Drosophila melanogaster)
Insecta spdo 37
  • 34 (a)
Species with no ortholog for TMOD2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMOD2 Gene

ENSEMBL:
Gene Tree for TMOD2 (if available)
TreeFam:
Gene Tree for TMOD2 (if available)

Paralogs for TMOD2 Gene

Paralogs for TMOD2 Gene

(8) SIMAP similar genes for TMOD2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with TMOD2: view

Variants for TMOD2 Gene

Sequence variations from dbSNP and Humsavar for TMOD2 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs34791185 - 51,768,322(+) CCGGC(C/G)CCTTT reference, missense
rs5812567 -- 51,761,257(+) AAAAA(-/TGT)TGTGC intron-variant
rs494447 -- 51,781,823(-) cacac(A/T)cTCTC intron-variant
rs6493518 -- 51,757,894(+) ACCCT(A/G)TCTCT intron-variant
rs6493519 -- 51,770,910(+) TTGCT(A/G)TTGGA intron-variant

Variation tolerance for TMOD2 Gene

Residual Variation Intolerance Score: 17.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.61; 45.16% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for TMOD2 Gene

Disorders for TMOD2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TMOD2 Gene - From: DISEASES and Novoseek

Disorder Aliases PubMed IDs
amyotrophic lateral sclerosis 1
  • amyotrophic lateral sclerosis
- elite association - COSMIC cancer census association via MalaCards
Search TMOD2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TMOD2

Genetic Association Database (GAD)
TMOD2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMOD2
genes like me logo Genes that share disorders with TMOD2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TMOD2 Gene

Publications for TMOD2 Gene

  1. Sequencing, expression analysis, and mapping of three unique human tropomodulin genes and their mouse orthologs. (PMID: 10662549) Cox P.R. … Zoghbi H.Y. (Genomics 2000) 2 3 4 23 67
  2. Luzp4 defines a new mRNA export pathway in cancer cells. (PMID: 25662211) Viphakone N. … Wilson S.A. (Nucleic Acids Res. 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. The P-body component USP52/PAN2 is a novel regulator of HIF1A mRNA stability. (PMID: 23398456) Bett J.S. … Hay R.T. (Biochem. J. 2013) 3

Products for TMOD2 Gene

Sources for TMOD2 Gene

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