Aliases for TMOD1 Gene
External Ids for TMOD1 Gene
Previous HGNC Symbols for TMOD1 Gene
Previous GeneCards Identifiers for TMOD1 Gene
This gene encodes a member of the tropomodulin family. The encoded protein is an actin-capping protein that regulates tropomyosin by binding to its N-terminus, inhibiting depolymerization and elongation of the pointed end of actin filaments and thereby influencing the structure of the erythrocyte membrane skeleton. Multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Oct 2009]
GeneCards Summary for TMOD1 Gene
TMOD1 (Tropomodulin 1) is a Protein Coding gene. Among its related pathways are Striated Muscle Contraction. GO annotations related to this gene include actin binding and tropomyosin binding. An important paralog of this gene is LMOD1.
UniProtKB/Swiss-Prot for TMOD1 Gene
Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton. May play an important role in regulating the organization of actin filaments by preferentially binding to a specific tropomyosin isoform at its N-terminus.