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TMOD1 Gene

protein-coding   GIFtS: 55
GCID: GC09P100263

Tropomodulin 1


(Previous symbols: D9S57E, TMOD)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tropomodulin 11 2     E-Tmod2 3
TMOD1 2 3 5     ETMOD2
D9S57E1 2 3     e-tropomodulin2
Erythrocyte Tropomodulin2 3     tropomodulin-12

External Ids:    HGNC: 118711   Entrez Gene: 71112   Ensembl: ENSG000001368427   OMIM: 1909305   UniProtKB: P282893   

Export aliases for TMOD1 gene to outside databases

Previous GC identifers: GC09P092029 GC09P093743 GC09P095643 GC09P095666 GC09P097343 GC09P099303 GC09P069864


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TMOD1 Gene:
This gene encodes a member of the tropomodulin family. The encoded protein is an actin-capping protein that
regulates tropomyosin by binding to its N-terminus, inhibiting depolymerization and elongation of the pointed end
of actin filaments and thereby influencing the structure of the erythrocyte membrane skeleton. Multiple
transcript variants encoding the same protein have been found for this gene. (provided by RefSeq, Oct 2009)

GeneCards Summary for TMOD1 Gene:
TMOD1 (tropomodulin 1) is a protein-coding gene. GO annotations related to this gene include actin binding and tropomyosin binding. An important paralog of this gene is LMOD3.

UniProtKB/Swiss-Prot: TMOD1_HUMAN, P28289
Function: Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM
complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the
membrane skeleton. May play an important role in regulating the organization of actin filaments by preferentially
binding to a specific tropomyosin isoform at its N-terminus

Gene Wiki entry for TMOD1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NC_018920.2  NT_008470.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the TMOD1 gene promoter:
         AREB6   PPAR-gamma1   GATA-6   MyoD   PPAR-gamma2   E4BP4   FOXL1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMOD1 promoter sequence
   Search Chromatin IP Primers for TMOD1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TMOD1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q22.3   Ensembl cytogenetic band:  9q22.33   HGNC cytogenetic band: 9q22

TMOD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMOD1 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P100263:  view genomic region     (about GC identifiers)

Start:
100,263,462 bp from pter      End:
100,364,030 bp from pter
Size:
100,569 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TMOD1_HUMAN, P28289 (See protein sequence)
Recommended Name: Tropomodulin-1  
Size: 359 amino acids; 40569 Da
Subunit: Binds to the N-terminus of isoforms 2/3 of TPM3 and to actin
Secondary accessions: B2RB77 Q9BUF1

Explore the universe of human proteins at neXtProt for TMOD1: NX_P28289

Explore proteomics data for TMOD1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TMOD1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001159588.1  NP_003266.1  

    ENSEMBL proteins: 
     ENSP00000259365   ENSP00000364318   ENSP00000378637  
    Reactome Protein details: P28289

    TMOD1 Human Recombinant Protein Products:

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    antibodies-online proteins for TMOD1 (11 products) 

     
    antibodies-online peptides for TMOD1

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR004934 Tropomodulin

    Graphical View of Domain Structure for InterPro Entry P28289

    ProtoNet protein and cluster: P28289

    1 Blocks protein domain: IPB004934 Tropomodulin

    UniProtKB/Swiss-Prot: TMOD1_HUMAN, P28289
    Similarity: Belongs to the tropomodulin family


    Find genes that share domains with TMOD1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TMOD1_HUMAN, P28289
    Function: Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM
    complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the
    membrane skeleton. May play an important role in regulating the organization of actin filaments by preferentially
    binding to a specific tropomyosin isoform at its N-terminus

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
    GO:0005523tropomyosin binding IEA--
         
    Find genes that share ontologies with TMOD1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for TMOD1:
     Small cells 

         8 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Tmod1):
     cardiovascular system  craniofacial  embryogenesis  growth/size/body  hematopoietic system 
     homeostasis/metabolism  mortality/aging  muscle 

    Find genes that share phenotypes with TMOD1           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TMOD1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TMOD1
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    Selected qRT-PCR Assays for microRNAs that regulate TMOD1 (see all 51):
    hsa-miR-21* hsa-miR-582-3p hsa-miR-142-5p hsa-miR-3164 hsa-miR-134 hsa-miR-301a hsa-miR-124 hsa-miR-298
    SwitchGear 3'UTR luciferase reporter plasmidTMOD1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TMOD1

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMOD1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TMOD1_HUMAN, P28289: Cytoplasm, cytoskeleton
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol4
    nucleus2

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0005856cytoskeleton ----
    GO:0008180colocalizes with COP9 signalosome IDA18850735
    GO:0016020membrane IEA--
    GO:0030016myofibril IEA--

    Find genes that share ontologies with TMOD1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TMOD1 About    
    See pathways by source

    SuperPathContained pathways About
    1Striated Muscle Contraction
    Striated Muscle Contraction0.82
    Muscle contraction0.61
    Striated Muscle Contraction0.82


    Find genes that share SuperPaths with TMOD1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for TMOD1
        Striated Muscle Contraction


    1 Reactome Pathway for TMOD1
        Striated Muscle Contraction


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TMOD1
    Interactions:

        GeneGlobe Interaction Network for TMOD1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TMOD1 (P282893 ENSP000002593654) via UniProtKB, MINT, STRING, and/or I2D (see all 43)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NEBP209293, ENSP000003862594I2D: score=2 STRING: ENSP00000386259
    COPS5Q929053, ENSP000003505124I2D: score=1 STRING: ENSP00000350512
    TMSB10P633133, ENSP000002331434I2D: score=1 STRING: ENSP00000233143
    PRKCEQ021563I2D: score=1 
    SNX33Q8WV413I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006936muscle contraction ----
    GO:0008344adult locomotory behavior IEA--
    GO:0030049muscle filament sliding TAS--
    GO:0030239myofibril assembly IEA--

    Find genes that share ontologies with TMOD1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TMOD1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TMOD1 gene (2 alternative transcripts): 
    NM_001166116.1  NM_003275.3  

    Unigene Cluster for TMOD1:

    Tropomodulin 1
    Hs.404289  [show with all ESTs]
    Unigene Representative Sequence: NM_003275
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000259365 ENST00000375175 ENST00000395211(uc004axl.2 uc004axk.2)

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate TMOD1 (see all 51):
    hsa-miR-21* hsa-miR-582-3p hsa-miR-142-5p hsa-miR-3164 hsa-miR-134 hsa-miR-301a hsa-miR-124 hsa-miR-298
    SwitchGear 3'UTR luciferase reporter plasmidTMOD1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TMOD1
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TMOD1
      QuantiTect SYBR Green Assays in human, mouse, rat TMOD1
      QuantiFast Probe-based Assays in human, mouse, rat TMOD1

    Additional mRNA sequence: 

    AK095748.1 AK096156.1 AK314533.1 BC002660.2 M77016.1 

    10 DOTS entries:

    DT.448680  DT.100786207  DT.447207  DT.95369662  DT.100786210  DT.100037847  DT.121158367  DT.92013476 
    DT.99997182  DT.100016606 

    Selected AceView cDNA sequences (see all 170):

    BC002660 BQ926270 AW206101 BX281921 BU615401 CA437084 R00848 AI127379 
    AK096156 AA706643 BE857120 CA429446 BM996455 N90795 BM678116 CA949991 
    BQ130530 BE858765 AA455871 BQ897320 AK095748 CD106367 AV718383 BU783086 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TMOD1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGCAGGGAC
    TMOD1 Expression
    About this image


    TMOD1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Neurons
             Mature Horizontal Cells Inner Nuclear Layer
             Ventral/hypothalamic-like neurons
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Mature Choroid Plexus Cells Choroid Plexus
             Ventral/hypothalamic-like neurons
     
     Heart (Cardiovascular System)
             Cardiomyocyte-like progenitor cells
     
     Epithelial Cells
             Mature Choroid Plexus Cells Choroid Plexus
     
     NULL (Uncategorized)
             Definitive endoderm-like cells
    TMOD1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TMOD1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.404289

    UniProtKB/Swiss-Prot: TMOD1_HUMAN, P28289
    Tissue specificity: Highly expressed in the erythrocyte, heart and skeletal muscle

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TMOD1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tmod11 , 5 tropomodulin 11, 5 89.6(n)1
    96.94(a)1
      4 (24.49 cM)5
    219161  NM_021883.21  NP_068683.11 
     460389355 
    chicken
    (Gallus gallus)
    Aves TMOD11 tropomodulin 1 77.16(n)
    86.35(a)
      395883  NM_205027.1  NP_990358.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    85(a)
    81(a)
    1 ↔ many
    1 ↔ many
    GL343544.1(798-35742)
    GL343391.1(21-66632)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia tmod11 tropomodulin 1 73.91(n)
    83.29(a)
      100486576  XM_004910901.1  XP_004910958.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tmod11 tropomodulin 1 69.87(n)
    79.1(a)
      100149766  XM_001920567.2  XP_001920602.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta tmod1 tropomodulin 49.18(n)
    38.26(a)
      43633  NM_001260443.2  NP_001247372.1 
    worm
    (Caenorhabditis elegans)
    Secernentea unc-941 unc-94 47.56(n)
    40.3(a)
      172275  NM_059333.3  NP_491734.1 


    ENSEMBL Gene Tree for TMOD1 (if available)
    TreeFam Gene Tree for TMOD1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TMOD1 gene
    LMOD32  TMOD42  LMOD22  TMOD32  LMOD12  TMOD22  
    7 SIMAP similar genes for TMOD1 using alignment to 2 protein entries:     TMOD1_HUMAN (see all proteins):
    DKFZp686E1899    TMOD3    TMOD2    TMOD4    LMOD2    LMOD1
    LMOD3

    Find genes that share paralogs with TMOD1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TMOD1 (see all 2046)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1501816921,2
    --100261488(+) ACCCTG/TTCTTT 1 -- us2k10--------
    rs123469341,2
    C--100261656(+) aaaaaC/Aaaaca 1 -- us2k1 tfbs3 trp31Minor allele frequency- A:0.50NA 2
    rs2002897181,2
    --100261660(+) AAAAC-/AAAACA 1 -- us2k10--------
    rs2019077051,2
    C--100261668(+) ACAAAA/CAAAAA 1 -- us2k10--------
    rs108176761,2
    C,F,A,H--100261672(+) ACAAAC/AAAAAA 1 -- us2k1 tfbs3 trp37Minor allele frequency- A:0.29NA WA 14
    rs1158432281,2
    C,F--100261788(+) CAGCCT/CGGGCA 1 -- us2k11Minor allele frequency- C:0.04WA 118
    rs1460376181,2
    --100261866(+) GTAATC/TCCAGC 1 -- us2k10--------
    rs792831171,2
    C,F--100261921(+) AGGAGG/ATTGAG 2 -- us2k11Minor allele frequency- A:0.08EA 120
    rs1386536391,2
    C--100261935(+) GCAATA/GAGCCG 2 -- us2k10--------
    rs1417837721,2
    --100262027(+) AAACCG/TAAACA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for TMOD1 (100263462 - 100364030 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for TMOD1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv893609CNV Gain21882294
    nsv893610CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 190930    OMIM disorders: --


    Find genes that share disorders with TMOD1           About GenesLikeMe

    Genetic Association Database (GAD): TMOD1

    Export disorders for TMOD1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TMOD1 gene, integrated from 10 sources (see all 51):
    (articles sorted by number of sources associating them with TMOD1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of human fetal liver tropomodulin. A tropomyosin-binding protein. (PubMed id 1370827)1, 2, 3, 9 Sung L.A.... Chien S. (J. Biol. Chem. 1992)
    2. Genomic organization of mouse and human erythrocyte tropomodulin genes encoding the pointed end capping protein for the actin filaments. (PubMed id 11054557)1, 2, 9 Chu X.... Sung L.A. (Gene 2000)
    3. Erythrocyte tropomodulin binds to the N-terminus of hTM5, a tropomyosin isoform encoded by the gamma-tropomyosin gene. (PubMed id 8002995)1, 2, 9 Sung L.A. and Lin J.J.-C. (Biochem. Biophys. Res. Commun. 1994)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (Nature 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Gene assignment, expression, and homology of human tropomodulin. (PubMed id 8661028)1, 3 Sung L.A....Lin C.C. (Genomics 1996)
    8. The N-terminal end of nebulin interacts with tropomodulin at the pointed ends of the thin filaments. (PubMed id 11016930)1, 9 McElhinny A.S....Gregorio C.C. (J. Biol. Chem. 2001)
    9. Mapping the tropomyosin isoform 5 binding site on human erythrocyte tropomodulin: further insights into E-Tmod/TM5 interaction. (PubMed id 16297372)1, 9 Vera C....Sung L.A. (Arch. Biochem. Biophys. 2005)
    10. Tropomyosin requires an intact N-terminal coiled coil to interact with tropomodulin. (PubMed id 11964245)1, 9 Greenfield N.J. and Fowler V.M. (Biophys. J. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
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      Query String
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    OMIM
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7111 HGNC: 11871 AceView: TMOD1 Ensembl:ENSG00000136842 euGenes: HUgn7111
    ECgene: TMOD1 H-InvDB: TMOD1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TMOD1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TMOD1 gene:
    Search GeneIP for patents involving TMOD1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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