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Aliases for TMOD1 Gene

Aliases for TMOD1 Gene

  • TMOD 3 4 6
  • Erythrocyte Tropomodulin 3 4
  • Tropomodulin 1 2 3
  • D9S57E 3 4
  • E-Tmod 3 4
  • E-Tropomodulin 3
  • Tropomodulin-1 3
  • ETMOD 3

External Ids for TMOD1 Gene

Previous HGNC Symbols for TMOD1 Gene

  • D9S57E
  • TMOD

Previous GeneCards Identifiers for TMOD1 Gene

  • GC09P092029
  • GC09P093743
  • GC09P095643
  • GC09P095666
  • GC09P097343
  • GC09P099303
  • GC09P100263
  • GC09P069864

Summaries for TMOD1 Gene

Entrez Gene Summary for TMOD1 Gene

  • This gene encodes a member of the tropomodulin family. The encoded protein is an actin-capping protein that regulates tropomyosin by binding to its N-terminus, inhibiting depolymerization and elongation of the pointed end of actin filaments and thereby influencing the structure of the erythrocyte membrane skeleton. Multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Oct 2009]

GeneCards Summary for TMOD1 Gene

TMOD1 is a Protein Coding gene. Among its related pathways are Striated Muscle Contraction and Striated Muscle Contraction. GO annotations related to this gene include actin binding and tropomyosin binding. An important paralog of this gene is LMOD1.

UniProtKB/Swiss-Prot for TMOD1 Gene

  • Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton. May play an important role in regulating the organization of actin filaments by preferentially binding to a specific tropomyosin isoform at its N-terminus.

Gene Wiki entry for TMOD1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMOD1 Gene

Genomics for TMOD1 Gene

Regulatory Elements for TMOD1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TMOD1 Gene

Start:
97,501,180 bp from pter
End:
97,601,748 bp from pter
Size:
100,569 bases
Orientation:
Plus strand

Genomic View for TMOD1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMOD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMOD1 Gene

Proteins for TMOD1 Gene

  • Protein details for TMOD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P28289-TMOD1_HUMAN
    Recommended name:
    Tropomodulin-1
    Protein Accession:
    P28289
    Secondary Accessions:
    • B2RB77
    • Q5T7W3
    • Q9BUF1

    Protein attributes for TMOD1 Gene

    Size:
    359 amino acids
    Molecular mass:
    40569 Da
    Quaternary structure:
    • Binds to the N-terminus of isoforms 2/3 of TPM3 and to actin

    Three dimensional structures from OCA and Proteopedia for TMOD1 Gene

    Alternative splice isoforms for TMOD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMOD1 Gene

Proteomics data for TMOD1 Gene at MOPED

Post-translational modifications for TMOD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMOD1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for TMOD1 Gene

Domains for TMOD1 Gene

Protein Domains for TMOD1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for TMOD1 Gene

Graphical View of Domain Structure for InterPro Entry

P28289

UniProtKB/Swiss-Prot:

TMOD1_HUMAN :
  • P28289
Family:
  • Belongs to the tropomodulin family.
genes like me logo Genes that share domains with TMOD1: view

No data available for Gene Families for TMOD1 Gene

Function for TMOD1 Gene

Molecular function for TMOD1 Gene

UniProtKB/Swiss-Prot Function: Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton. May play an important role in regulating the organization of actin filaments by preferentially binding to a specific tropomyosin isoform at its N-terminus.

Gene Ontology (GO) - Molecular Function for TMOD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding --
GO:0005523 tropomyosin binding IBA --
GO:0051015 actin filament binding IEA --
genes like me logo Genes that share ontologies with TMOD1: view
genes like me logo Genes that share phenotypes with TMOD1: view

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMOD1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TMOD1 Gene

Localization for TMOD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMOD1 Gene

Cytoplasm, cytoskeleton. Note=In myofibrils with sarcomeric structure, localizes to the pointed end of actin thin filaments (PubMed:25250574). {ECO:0000269 PubMed:25250574}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMOD1 Gene COMPARTMENTS Subcellular localization image for TMOD1 gene
Compartment Confidence
cytoskeleton 5
cytosol 4
nucleus 2

Gene Ontology (GO) - Cellular Components for TMOD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton --
GO:0005865 striated muscle thin filament IBA --
GO:0008180 colocalizes_with COP9 signalosome IDA 18850735
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with TMOD1: view

Pathways for TMOD1 Gene

genes like me logo Genes that share pathways with TMOD1: view

Pathways by source for TMOD1 Gene

1 BioSystems pathway for TMOD1 Gene
2 Reactome pathways for TMOD1 Gene

Gene Ontology (GO) - Biological Process for TMOD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006936 muscle contraction IBA --
GO:0007015 actin filament organization IBA --
GO:0008344 adult locomotory behavior IEA --
GO:0030049 muscle filament sliding TAS --
GO:0030239 myofibril assembly IBA --
genes like me logo Genes that share ontologies with TMOD1: view

Transcripts for TMOD1 Gene

mRNA/cDNA for TMOD1 Gene

Unigene Clusters for TMOD1 Gene

Tropomodulin 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMOD1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMOD1 Gene

No ASD Table

Relevant External Links for TMOD1 Gene

GeneLoc Exon Structure for
TMOD1
ECgene alternative splicing isoforms for
TMOD1

Expression for TMOD1 Gene

mRNA expression in normal human tissues for TMOD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMOD1 Gene

This gene is overexpressed in Muscle - Skeletal (6.9), Heart - Left Ventricle (5.5), and Heart - Atrial Appendage (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TMOD1 Gene

SOURCE GeneReport for Unigene cluster for TMOD1 Gene Hs.404289

mRNA Expression by UniProt/SwissProt for TMOD1 Gene

P28289-TMOD1_HUMAN
Tissue specificity: Highly expressed in the erythrocyte, heart and skeletal muscle
genes like me logo Genes that share expressions with TMOD1: view

In Situ Assay Products

Orthologs for TMOD1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMOD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMOD1 35
  • 99.72 (n)
  • 99.44 (a)
TMOD1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMOD1 35
  • 90.81 (n)
  • 97.49 (a)
TMOD1 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMOD1 35
  • 92.11 (n)
  • 98.05 (a)
TMOD1 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmod1 35
  • 89.6 (n)
  • 96.94 (a)
Tmod1 16
Tmod1 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMOD1 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMOD1 36
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmod1 35
  • 89.51 (n)
  • 96.66 (a)
chicken
(Gallus gallus)
Aves TMOD1 35
  • 77.16 (n)
  • 86.35 (a)
TMOD1 36
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 81 (a)
OneToMany
-- 36
  • 85 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia tmod1 35
  • 73.91 (n)
  • 83.29 (a)
zebrafish
(Danio rerio)
Actinopterygii tmod1 35
  • 69.87 (n)
  • 79.1 (a)
tmod1 36
  • 79 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000969 35
  • 50.2 (n)
  • 41.32 (a)
fruit fly
(Drosophila melanogaster)
Insecta tmod 35
  • 49.18 (n)
  • 38.26 (a)
worm
(Caenorhabditis elegans)
Secernentea unc-94 35
  • 47.56 (n)
  • 40.3 (a)
Species with no ortholog for TMOD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMOD1 Gene

ENSEMBL:
Gene Tree for TMOD1 (if available)
TreeFam:
Gene Tree for TMOD1 (if available)

Paralogs for TMOD1 Gene

Paralogs for TMOD1 Gene

Selected SIMAP similar genes for TMOD1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TMOD1: view

Variants for TMOD1 Gene

Sequence variations from dbSNP and Humsavar for TMOD1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs867585 -- 97,555,993(-) CTCCC(C/T)GGGTC intron-variant
rs913910 -- 97,514,999(+) TGCAG(C/T)ACACG intron-variant
rs913911 -- 97,556,176(-) CAATC(C/T)CACAG intron-variant
rs913912 -- 97,578,756(+) CATGT(C/T)AAGGG intron-variant
rs913913 -- 97,535,310(+) CCCAC(A/G)GAAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMOD1 Gene

Variant ID Type Subtype PubMed ID
nsv893609 CNV Gain 21882294
nsv893610 CNV Gain 21882294

Relevant External Links for TMOD1 Gene

HapMap Linkage Disequilibrium report
TMOD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMOD1 Gene

Disorders for TMOD1 Gene

Relevant External Links for TMOD1

Genetic Association Database (GAD)
TMOD1
genes like me logo Genes that share disorders with TMOD1: view

No data available for UniProtKB/Swiss-Prot for TMOD1 Gene

Publications for TMOD1 Gene

  1. Molecular cloning and characterization of human fetal liver tropomodulin. A tropomyosin-binding protein. (PMID: 1370827) Sung L.A. … Chien S. (J. Biol. Chem. 1992) 2 3 4 23
  2. Erythrocyte tropomodulin binds to the N-terminus of hTM5, a tropomyosin isoform encoded by the gamma-tropomyosin gene. (PMID: 8002995) Sung L.A. … Lin J.J.-C. (Biochem. Biophys. Res. Commun. 1994) 3 4 23
  3. Genomic organization of mouse and human erythrocyte tropomodulin genes encoding the pointed end capping protein for the actin filaments. (PMID: 11054557) Chu X. … Sung L.A. (Gene 2000) 3 4 23
  4. Gene assignment, expression, and homology of human tropomodulin. (PMID: 8661028) Sung L.A. … Lin C.C. (Genomics 1996) 2 3
  5. Mapping the tropomyosin isoform 5 binding site on human erythrocyte tropomodulin: further insights into E-Tmod/TM5 interaction. (PMID: 16297372) Vera C. … Sung L.A. (Arch. Biochem. Biophys. 2005) 3 23

Products for TMOD1 Gene

Sources for TMOD1 Gene

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