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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TMOD1 Gene

protein-coding   GIFtS: 56
GCID: GC09P100263

Tropomodulin 1


(Previous symbols: D9S57E, TMOD)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Tropomodulin 11 2     E-Tmod2 3
TMOD1 2 3 5     ETMOD2
D9S57E1 2 3     e-tropomodulin2
Erythrocyte Tropomodulin2 3     tropomodulin-12

External Ids:    HGNC: 118711   Entrez Gene: 71112   Ensembl: ENSG000001368427   OMIM: 1909305   UniProtKB: P282893   

Export aliases for TMOD1 gene to outside databases

Previous GC identifers: GC09P092029 GC09P093743 GC09P095643 GC09P095666 GC09P097343 GC09P099303 GC09P069864


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TMOD1 Gene:
This gene encodes a member of the tropomodulin family. The encoded protein is an actin-capping protein that
regulates tropomyosin by binding to its N-terminus, inhibiting depolymerization and elongation of the pointed end
of actin filaments and thereby influencing the structure of the erythrocyte membrane skeleton. Multiple
transcript variants encoding the same protein have been found for this gene. (provided by RefSeq, Oct 2009)

GeneCards Summary for TMOD1 Gene: 
TMOD1 (tropomodulin 1) is a protein-coding gene. Diseases associated with TMOD1 include transitional cell carcinoma, and endotheliitis, and among its related super-pathways are Striated Muscle Contraction. GO annotations related to this gene include actin binding and tropomyosin binding. An important paralog of this gene is LMOD3.

UniProtKB/Swiss-Prot: TMOD1_HUMAN, P28289
Function: Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM
complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the
membrane skeleton. May play an important role in regulating the organization of actin filaments by preferentially
binding to a specific tropomyosin isoform at its N-terminus

Gene Wiki entry for TMOD1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NT_008470.19  NC_018920.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TMOD1 gene promoter:
         AREB6   PPAR-gamma1   GATA-6   MyoD   PPAR-gamma2   E4BP4   FOXL1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMOD1 promoter sequence
   Search SABiosciences Chromatin IP Primers for TMOD1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMOD1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q22.3   Ensembl cytogenetic band:  9q22.33   HGNC cytogenetic band: 9q22

TMOD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMOD1 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P100263:  view genomic region     (about GC identifiers)

Start:
100,263,462 bp from pter      End:
100,364,025 bp from pter
Size:
100,564 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TMOD1_HUMAN, P28289 (See protein sequence)
Recommended Name: Tropomodulin-1  
Size: 359 amino acids; 40569 Da
Subunit: Binds to the N-terminus of isoforms 2/3 of TPM3 and to actin
Subcellular location: Cytoplasm, cytoskeleton
Secondary accessions: B2RB77 Q9BUF1

Explore the universe of human proteins at neXtProt for TMOD1: NX_P28289

Explore proteomics data for TMOD1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P28289

  • TMOD1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TMOD1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001159588.1  NP_003266.1  

    ENSEMBL proteins: 
     ENSP00000259365   ENSP00000364318   ENSP00000378637  
    Reactome Protein details: P28289
    Human Recombinant Protein Products for TMOD1: 
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    Novus Biologicals TMOD1 Proteins
    Novus Biologicals TMOD1 Lysates
    Browse Sino Biological Recombinant Proteins
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    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TMOD1 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0005856cytoskeleton ----
    GO:0008180colocalizes with COP9 signalosome IDA18850735
    GO:0016020membrane IEA--
    GO:0030016myofibril IEA--

    TMOD1 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for TMOD1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR004934 Tropomodulin

    Graphical View of Domain Structure for InterPro Entry P28289

    ProtoNet protein and cluster: P28289

    1 Blocks protein domain: IPB004934 Tropomodulin

    UniProtKB/Swiss-Prot: TMOD1_HUMAN, P28289
    Similarity: Belongs to the tropomodulin family


    TMOD1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TMOD1_HUMAN, P28289
    Function: Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM
    complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the
    membrane skeleton. May play an important role in regulating the organization of actin filaments by preferentially
    binding to a specific tropomyosin isoform at its N-terminus

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
    GO:0005523tropomyosin binding IEA--
         
    TMOD1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for TMOD1:
     Small cells 

         7 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Tmod1):
     cardiovascular system  embryogenesis  growth/size  hematopoietic system  homeostasis/metabolism 
     mortality/aging  muscle 

    TMOD1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TMOD1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TMOD1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TMOD1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TMOD1 

    miRNA
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    8/51 QIAGEN miScript miRNA Assays for microRNAs that regulate TMOD1 (see all 51):
    hsa-miR-21* hsa-miR-582-3p hsa-miR-142-5p hsa-miR-3164 hsa-miR-134 hsa-miR-301a hsa-miR-124 hsa-miR-298
    SwitchGear 3'UTR luciferase reporter plasmidTMOD1 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Clone
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMOD1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TMOD1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Striated Muscle Contraction
    Striated Muscle Contraction0.87
    Muscle contraction0.65
    Striated Muscle Contraction0.87

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for TMOD1
        Striated Muscle Contraction


    2        Reactome Pathways for TMOD1
        Muscle contraction
    Striated Muscle Contraction



    TMOD1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TMOD1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/32 Interacting proteins for TMOD1 (P282893 ENSP000002593654) via UniProtKB, MINT, STRING, and/or I2D (see all 32)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NEBP209293, ENSP000003862594I2D: score=2 STRING: ENSP00000386259
    COPS5Q929053, ENSP000003505124I2D: score=1 STRING: ENSP00000350512
    TMSB10P633133, ENSP000002331434I2D: score=1 STRING: ENSP00000233143
    PRKCEQ021563I2D: score=1 
    SNX33Q8WV413I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006936muscle contraction ----
    GO:0008344adult locomotory behavior IEA--
    GO:0030049muscle filament sliding TAS--
    GO:0030239myofibril assembly IEA--

    TMOD1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TMOD1

    Search CenterWatch for drugs/clinical trials and news about TMOD1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TMOD1 gene (2 alternative transcripts): 
    NM_001166116.1  NM_003275.3  

    Unigene Cluster for TMOD1:

    Tropomodulin 1
    Hs.404289  [show with all ESTs]
    Unigene Representative Sequence: NM_003275
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000259365 ENST00000375175 ENST00000395211(uc004axl.2 uc004axk.2)

    miRNA
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    8/51 QIAGEN miScript miRNA Assays for microRNAs that regulate TMOD1 (see all 51):
    hsa-miR-21* hsa-miR-582-3p hsa-miR-142-5p hsa-miR-3164 hsa-miR-134 hsa-miR-301a hsa-miR-124 hsa-miR-298
    SwitchGear 3'UTR luciferase reporter plasmidTMOD1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMOD1
    Clone
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    OriGene clones in human, mouse for TMOD1 (see all 13)
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TMOD1 (NM_003275)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMOD1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMOD1
    Sirion Biotech Customized lentivirus for stable overexpression of TMOD1 
                         Customized lentivirus expression plasmids for stable overexpression of TMOD1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TMOD1
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMOD1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMOD1

    Additional mRNA sequence: 

    AK095748.1 AK096156.1 AK314533.1 BC002660.2 M77016.1 

    10 DOTS entries:

    DT.448680  DT.100786207  DT.447207  DT.95369662  DT.100786210  DT.100037847  DT.121158367  DT.92013476 
    DT.99997182  DT.100016606 

    24/170 AceView cDNA sequences (see all 170):

    BM678116 CA949991 BQ130530 BE858765 AA455871 BQ897320 AK095748 CD106367 
    AV718383 BU783086 NM_003275 BU742517 M77016 BE395424 CA774894 AI523711 
    BU070595 AI879136 CA943804 BC002660 BQ926270 AW206101 BX281921 BU615401 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TMOD1 expression in normal human tissues (normalized intensities)      TMOD1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGCAGGGAC
    TMOD1 Expression
    About this image


    TMOD1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/14 selected tissues (see all 14) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Bone Marrow CD105+ Cells   
     
     Heart (Cardiovascular System)
             Cardiomyocyte-like progenitor cells ( Derivation of cardiomyocytes from pluripotent...
     
     Primitive Streak (Early Embryonic Tissues)
             Definitive endoderm-like cells ( Generation and expansion of endodermal progenitor...
     
     Nose (Sensory Organs)
             sensory organ/nose/nasal cavity   
     
     Bone (Muscoskeletal System)
             Human Mesenchymal Stem Cell-bone marrow (HMSC-Bone Marrow)   

    See TMOD1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TMOD1

    SOURCE GeneReport for Unigene cluster: Hs.404289

    UniProtKB/Swiss-Prot: TMOD1_HUMAN, P28289
    Tissue specificity: Highly expressed in the erythrocyte, heart and skeletal muscle

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMOD1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TMOD1 gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tmod11 , 5 tropomodulin 11, 5 89.6(n)1
    96.94(a)1
      4 (24.49 cM)5
    219161  NM_021883.21  NP_068683.11 
     460389355 
    chicken
    (Gallus gallus)
    Aves TMOD11 tropomodulin 1 77.16(n)
    86.35(a)
      395883  NM_205027.1  NP_990358.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    --
    85(a)
    81(a)
    1 ↔ many
    1 ↔ many
    GL343544.1(798-35742)
    GL343391.1(21-66632)
    zebrafish
    (Danio rerio)
    Actinopterygii tmod11 tropomodulin 1 69.87(n)
    79.1(a)
      100149766  XM_001920567.1  XP_001920602.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta tmod1 tropomodulin 48.87(n)
    38.35(a)
      43633  NM_170506.3  NP_733385.1 
    worm
    (Caenorhabditis elegans)
    Secernentea unc-941 Protein UNC-94 47.85(n)
    40.54(a)
      172275  NM_059333.2  NP_491734.1 


    ENSEMBL Gene Tree for TMOD1 (if available)
    TreeFam Gene Tree for TMOD1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TMOD1 gene
    LMOD32  LMOD22  TMOD42  TMOD32  LMOD12  TMOD22  
    7 SIMAP similar genes for TMOD1 using alignment to 2 protein entries:     TMOD1_HUMAN (see all proteins):
    DKFZp686E1899    TMOD3    TMOD2    TMOD4    LMOD2    LMOD1
    LMOD3

    TMOD1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2046 SNPs in TMOD1 are shown (see all 2046)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1501816921,2
    --100261488(+) ACCCTG/TTCTTT 1 -- us2k10--------
    rs123469341,2
    C--100261656(+) aaaaaC/Aaaaca 1 -- us2k1 tfbs3 trp31Minor allele frequency- A:0.50NA 2
    rs2002897181,2
    --100261660(+) AAAAC-/AAAACA 1 -- us2k10--------
    rs2019077051,2
    C--100261668(+) ACAAAA/CAAAAA 1 -- us2k10--------
    rs108176761,2
    C,F,A,H--100261672(+) ACAAAC/AAAAAA 1 -- us2k1 tfbs3 trp37Minor allele frequency- A:0.29NA WA 14
    rs1158432281,2
    C,F--100261788(+) CAGCCT/CGGGCA 1 -- us2k11Minor allele frequency- C:0.04WA 118
    rs1460376181,2
    --100261866(+) GTAATC/TCCAGC 1 -- us2k10--------
    rs792831171,2
    C,F--100261921(+) AGGAGG/ATTGAG 2 -- us2k11Minor allele frequency- A:0.08EA 120
    rs1386536391,2
    C--100261935(+) GCAATA/GAGCCG 2 -- us2k10--------
    rs1417837721,2
    --100262027(+) AAACCG/TAAACA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for TMOD1 (100263462 - 100364025 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for TMOD1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv893609CNV Gain21882294
    nsv893610CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing TMOD1
    DNA2.0 Custom Variant and Variant Library Synthesis for TMOD1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 190930    OMIM disorders: --

    3 diseases for TMOD1:    About MalaCards
    transitional cell carcinoma    endotheliitis    neuronitis


    TMOD1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TMOD1

    Export disorders for TMOD1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TMOD1 gene, integrated from 9 sources (see all 50):
    (articles sorted by number of sources associating them with TMOD1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of human fetal liver tropomodulin. A tropomyosin-binding protein. (PubMed id 1370827)1, 2, 3, 9 Sung L.A.... Chien S. (1992)
    2. Genomic organization of mouse and human erythrocyte tropomodulin genes encoding the pointed end capping protein for the actin filaments. (PubMed id 11054557)1, 2, 9 Chu X.... Sung L.A. (2000)
    3. Erythrocyte tropomodulin binds to the N-terminus of hTM5, a tropomyosin isoform encoded by the gamma-tropomyosin gene. (PubMed id 8002995)1, 2, 9 Sung L.A. and Lin J.J.-C. (1994)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Gene assignment, expression, and homology of human tropomodulin. (PubMed id 8661028)1, 3 Sung L.A....Lin C.C. (1996)
    8. The N-terminal end of nebulin interacts with tropomodulin at the pointed ends of the thin filaments. (PubMed id 11016930)1, 9 McElhinny A.S....Gregorio C.C. (2001)
    9. Mapping the tropomyosin isoform 5 binding site on human erythrocyte tropomodulin: further insights into E-Tmod/TM5 interaction. (PubMed id 16297372)1, 9 Vera C....Sung L.A. (2005)
    10. Tropomyosin requires an intact N-terminal coiled coil to interact with tropomodulin. (PubMed id 11964245)1, 9 Greenfield N.J. and Fowler V.M. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7111 HGNC: 11871 AceView: TMOD1 Ensembl:ENSG00000136842 euGenes: HUgn7111
    ECgene: TMOD1 H-InvDB: TMOD1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TMOD1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TMOD1 gene:
    Search GeneIP for patents involving TMOD1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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