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Aliases for TMOD1 Gene

Aliases for TMOD1 Gene

  • Tropomodulin 1 2 3 5
  • Erythrocyte Tropomodulin 3 4
  • D9S57E 3 4
  • E-Tmod 3 4
  • TMOD 3 4
  • E-Tropomodulin 3
  • ETMOD 3

External Ids for TMOD1 Gene

Previous HGNC Symbols for TMOD1 Gene

  • D9S57E
  • TMOD

Previous GeneCards Identifiers for TMOD1 Gene

  • GC09P092029
  • GC09P093743
  • GC09P095643
  • GC09P095666
  • GC09P097343
  • GC09P099303
  • GC09P100263
  • GC09P069864

Summaries for TMOD1 Gene

Entrez Gene Summary for TMOD1 Gene

  • This gene encodes a member of the tropomodulin family. The encoded protein is an actin-capping protein that regulates tropomyosin by binding to its N-terminus, inhibiting depolymerization and elongation of the pointed end of actin filaments and thereby influencing the structure of the erythrocyte membrane skeleton. Multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Oct 2009]

GeneCards Summary for TMOD1 Gene

TMOD1 (Tropomodulin 1) is a Protein Coding gene. Among its related pathways are Cardiac conduction and Striated Muscle Contraction. GO annotations related to this gene include actin binding and tropomyosin binding. An important paralog of this gene is LMOD1.

UniProtKB/Swiss-Prot for TMOD1 Gene

  • Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton. May play an important role in regulating the organization of actin filaments by preferentially binding to a specific tropomyosin isoform at its N-terminus.

Gene Wiki entry for TMOD1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMOD1 Gene

Genomics for TMOD1 Gene

Regulatory Elements for TMOD1 Gene

Promoters for TMOD1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TMOD1 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMOD1 Gene

Chromosome:
9
Start:
97,501,180 bp from pter
End:
97,601,748 bp from pter
Size:
100,569 bases
Orientation:
Plus strand

Genomic View for TMOD1 Gene

Genes around TMOD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMOD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMOD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMOD1 Gene

Proteins for TMOD1 Gene

  • Protein details for TMOD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P28289-TMOD1_HUMAN
    Recommended name:
    Tropomodulin-1
    Protein Accession:
    P28289
    Secondary Accessions:
    • B2RB77
    • Q5T7W3
    • Q9BUF1

    Protein attributes for TMOD1 Gene

    Size:
    359 amino acids
    Molecular mass:
    40569 Da
    Quaternary structure:
    • Binds to the N-terminus of isoforms 2/3 of TPM3 and to actin.

    Three dimensional structures from OCA and Proteopedia for TMOD1 Gene

    Alternative splice isoforms for TMOD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMOD1 Gene

Proteomics data for TMOD1 Gene at MOPED

Post-translational modifications for TMOD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMOD1 Gene

Antibody Products

  • Cloud-Clone Corp. Antibodies for TMOD1

No data available for DME Specific Peptides for TMOD1 Gene

Domains & Families for TMOD1 Gene

Gene Families for TMOD1 Gene

Protein Domains for TMOD1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for TMOD1 Gene

Graphical View of Domain Structure for InterPro Entry

P28289

UniProtKB/Swiss-Prot:

TMOD1_HUMAN :
  • Belongs to the tropomodulin family.
Family:
  • Belongs to the tropomodulin family.
genes like me logo Genes that share domains with TMOD1: view

Function for TMOD1 Gene

Molecular function for TMOD1 Gene

UniProtKB/Swiss-Prot Function:
Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton. May play an important role in regulating the organization of actin filaments by preferentially binding to a specific tropomyosin isoform at its N-terminus.

Gene Ontology (GO) - Molecular Function for TMOD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051015 actin filament binding IEA --
genes like me logo Genes that share ontologies with TMOD1: view
genes like me logo Genes that share phenotypes with TMOD1: view

Animal Models for TMOD1 Gene

MGI Knock Outs for TMOD1:

Animal Model Products

  • Taconic Biosciences Mouse Models for TMOD1

miRNA for TMOD1 Gene

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TMOD1 Gene

Localization for TMOD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMOD1 Gene

Cytoplasm, cytoskeleton. Note=In myofibrils with sarcomeric structure, localizes to the pointed end of actin thin filaments (PubMed:25250574). {ECO:0000269 PubMed:25250574}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMOD1 Gene COMPARTMENTS Subcellular localization image for TMOD1 gene
Compartment Confidence
cytosol 5
cytoskeleton 4
nucleus 3

Gene Ontology (GO) - Cellular Components for TMOD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0016020 membrane IEA --
GO:0030017 sarcomere IEA --
genes like me logo Genes that share ontologies with TMOD1: view

Pathways & Interactions for TMOD1 Gene

genes like me logo Genes that share pathways with TMOD1: view

Pathways by source for TMOD1 Gene

1 BioSystems pathway for TMOD1 Gene
2 Reactome pathways for TMOD1 Gene

Gene Ontology (GO) - Biological Process for TMOD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007015 actin filament organization IBA --
GO:0070307 lens fiber cell development IEA --
genes like me logo Genes that share ontologies with TMOD1: view

No data available for SIGNOR curated interactions for TMOD1 Gene

Drugs & Compounds for TMOD1 Gene

No Compound Related Data Available

Transcripts for TMOD1 Gene

Unigene Clusters for TMOD1 Gene

Tropomodulin 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMOD1 Gene

No ASD Table

Relevant External Links for TMOD1 Gene

GeneLoc Exon Structure for
TMOD1
ECgene alternative splicing isoforms for
TMOD1

Expression for TMOD1 Gene

mRNA expression in normal human tissues for TMOD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMOD1 Gene

This gene is overexpressed in Muscle - Skeletal (x6.9), Heart - Left Ventricle (x5.5), and Heart - Atrial Appendage (x4.4).

Protein differential expression in normal tissues from HIPED for TMOD1 Gene

This gene is overexpressed in Heart (21.4) and Fetal heart (11.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TMOD1 Gene



SOURCE GeneReport for Unigene cluster for TMOD1 Gene Hs.404289

mRNA Expression by UniProt/SwissProt for TMOD1 Gene

P28289-TMOD1_HUMAN
Tissue specificity: Highly expressed in the erythrocyte, heart and skeletal muscle.
genes like me logo Genes that share expression patterns with TMOD1: view

Protein tissue co-expression partners for TMOD1 Gene

Primer Products

In Situ Assay Products

Orthologs for TMOD1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMOD1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TMOD1 35
  • 90.81 (n)
  • 97.49 (a)
TMOD1 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMOD1 35
  • 92.11 (n)
  • 98.05 (a)
TMOD1 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmod1 35
  • 89.6 (n)
  • 96.94 (a)
Tmod1 16
Tmod1 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TMOD1 35
  • 99.72 (n)
  • 99.44 (a)
TMOD1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmod1 35
  • 89.51 (n)
  • 96.66 (a)
oppossum
(Monodelphis domestica)
Mammalia TMOD1 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMOD1 36
  • 92 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMOD1 35
  • 77.16 (n)
  • 86.35 (a)
TMOD1 36
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 81 (a)
OneToMany
-- 36
  • 85 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia tmod1 35
  • 73.91 (n)
  • 83.29 (a)
zebrafish
(Danio rerio)
Actinopterygii tmod1 35
  • 69.87 (n)
  • 79.1 (a)
tmod1 36
  • 79 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000969 35
  • 50.2 (n)
  • 41.32 (a)
fruit fly
(Drosophila melanogaster)
Insecta tmod 35
  • 49.18 (n)
  • 38.26 (a)
worm
(Caenorhabditis elegans)
Secernentea unc-94 35
  • 47.56 (n)
  • 40.3 (a)
Species with no ortholog for TMOD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMOD1 Gene

ENSEMBL:
Gene Tree for TMOD1 (if available)
TreeFam:
Gene Tree for TMOD1 (if available)

Paralogs for TMOD1 Gene

Paralogs for TMOD1 Gene

(7) SIMAP similar genes for TMOD1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TMOD1: view

Variants for TMOD1 Gene

Sequence variations from dbSNP and Humsavar for TMOD1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs957611 -- 97,510,056(+) CTTGC(C/T)GTTTG intron-variant
rs960008 -- 97,510,050(+) CCCCA(A/G)CTTGC intron-variant
rs867585 -- 97,555,993(-) CTCCC(C/T)GGGTC intron-variant
rs913911 -- 97,556,176(-) CAATC(C/T)CACAG intron-variant
rs913912 -- 97,578,756(+) CATGT(C/T)AAGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMOD1 Gene

Variant ID Type Subtype PubMed ID
nsv893609 CNV Gain 21882294
nsv893610 CNV Gain 21882294

Variation tolerance for TMOD1 Gene

Residual Variation Intolerance Score: 18.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.33; 26.43% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMOD1 Gene

HapMap Linkage Disequilibrium report
TMOD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMOD1 Gene

Disorders for TMOD1 Gene

Relevant External Links for TMOD1

Genetic Association Database (GAD)
TMOD1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMOD1

No disorders were found for TMOD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMOD1 Gene

Publications for TMOD1 Gene

  1. Molecular cloning and characterization of human fetal liver tropomodulin. A tropomyosin-binding protein. (PMID: 1370827) Sung L.A. … Chien S. (J. Biol. Chem. 1992) 2 3 4 23 67
  2. Mapping the tropomyosin isoform 5 binding site on human erythrocyte tropomodulin: further insights into E-Tmod/TM5 interaction. (PMID: 16297372) Vera C. … Sung L.A. (Arch. Biochem. Biophys. 2005) 3 23
  3. Tropomyosin requires an intact N-terminal coiled coil to interact with tropomodulin. (PMID: 11964245) Greenfield N.J. … Fowler V.M. (Biophys. J. 2002) 3 23
  4. The N-terminal end of nebulin interacts with tropomodulin at the pointed ends of the thin filaments. (PMID: 11016930) McElhinny A.S. … Gregorio C.C. (J. Biol. Chem. 2001) 3 23
  5. Genomic organization of mouse and human erythrocyte tropomodulin genes encoding the pointed end capping protein for the actin filaments. (PMID: 11054557) Chu X. … Sung L.A. (Gene 2000) 3 23

Products for TMOD1 Gene

Sources for TMOD1 Gene

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