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Aliases for TMIGD2 Gene

Aliases for TMIGD2 Gene

  • Transmembrane And Immunoglobulin Domain Containing 2 2 3 5
  • Immunoglobulin-Containing And Proline-Rich Receptor-1 2 3
  • Immunoglobulin And Proline-Rich Receptor 1 3 4
  • CD28 Homologue 2 3
  • CD28 Homolog 3 4
  • IGPR-1 3 4
  • CD28H 3 4
  • IGPR1 3 4
  • Transmembrane And Immunoglobulin Domain-Containing Protein 2 Variant 2 3
  • Transmembrane And Immunoglobulin Domain-Containing Protein 2 Variant 3 3
  • Immunoglobulin-Containing And Proline-Rich Receptor 1 3

External Ids for TMIGD2 Gene

Previous GeneCards Identifiers for TMIGD2 Gene

  • GC19M004244
  • GC19M004055

Summaries for TMIGD2 Gene

GeneCards Summary for TMIGD2 Gene

TMIGD2 (Transmembrane And Immunoglobulin Domain Containing 2) is a Protein Coding gene. Among its related pathways are T Cell Co-Signaling Pathway: Ligand-Receptor Interactions. GO annotations related to this gene include coreceptor activity.

UniProtKB/Swiss-Prot for TMIGD2 Gene

  • Plays a role in cell-cell interaction, cell migration, and angiogenesis. Through interaction with HHLA2, costimulates T-cells in the context of TCR-mediated activation. Enhances T-cell proliferation and cytokine production via an AKT-dependent signaling cascade.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMIGD2 Gene

Genomics for TMIGD2 Gene

Regulatory Elements for TMIGD2 Gene

Enhancers for TMIGD2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TMIGD2 on UCSC Golden Path with GeneCards custom track

Promoters for TMIGD2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TMIGD2 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMIGD2 Gene

4,292,227 bp from pter
4,302,582 bp from pter
10,356 bases
Minus strand

Genomic View for TMIGD2 Gene

Genes around TMIGD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMIGD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMIGD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMIGD2 Gene

Proteins for TMIGD2 Gene

  • Protein details for TMIGD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane and immunoglobulin domain-containing protein 2
    Protein Accession:
    Secondary Accessions:
    • Q6UW59

    Protein attributes for TMIGD2 Gene

    282 amino acids
    Molecular mass:
    30675 Da
    Quaternary structure:
    • May form homophilic interactions that could regulate cell-cell interaction. Interacts with CACNB2, DST, MIA and NCKIPSD. Interacts with HHLA2.

    Alternative splice isoforms for TMIGD2 Gene


neXtProt entry for TMIGD2 Gene

Proteomics data for TMIGD2 Gene at MOPED

Post-translational modifications for TMIGD2 Gene

Other Protein References for TMIGD2 Gene

No data available for DME Specific Peptides for TMIGD2 Gene

Domains & Families for TMIGD2 Gene

Gene Families for TMIGD2 Gene

Protein Domains for TMIGD2 Gene


Suggested Antigen Peptide Sequences for TMIGD2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 Ig-like (immunoglobulin-like) domain.
  • Contains 1 Ig-like (immunoglobulin-like) domain.
genes like me logo Genes that share domains with TMIGD2: view

Function for TMIGD2 Gene

Molecular function for TMIGD2 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in cell-cell interaction, cell migration, and angiogenesis. Through interaction with HHLA2, costimulates T-cells in the context of TCR-mediated activation. Enhances T-cell proliferation and cytokine production via an AKT-dependent signaling cascade.
genes like me logo Genes that share phenotypes with TMIGD2: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMIGD2 Gene

Localization for TMIGD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMIGD2 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for TMIGD2 Gene COMPARTMENTS Subcellular localization image for TMIGD2 gene
Compartment Confidence
plasma membrane 5
extracellular 4
cytosol 1
mitochondrion 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for TMIGD2 Gene

Pathways & Interactions for TMIGD2 Gene

genes like me logo Genes that share pathways with TMIGD2: view

Pathways by source for TMIGD2 Gene

1 R&D Systems pathway for TMIGD2 Gene

Interacting Proteins for TMIGD2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000301272 for TMIGD2 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for TMIGD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response IBA --
GO:0031295 T cell costimulation IDA 23784006
GO:0042104 positive regulation of activated T cell proliferation IDA 23784006
GO:0045766 positive regulation of angiogenesis IMP 22419821
genes like me logo Genes that share ontologies with TMIGD2: view

No data available for SIGNOR curated interactions for TMIGD2 Gene

Drugs & Compounds for TMIGD2 Gene

No Compound Related Data Available

Transcripts for TMIGD2 Gene

mRNA/cDNA for TMIGD2 Gene

(4) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMIGD2 Gene

Transmembrane and immunoglobulin domain containing 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMIGD2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5
SP2: -

Relevant External Links for TMIGD2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMIGD2 Gene

mRNA expression in normal human tissues for TMIGD2 Gene

mRNA differential expression in normal tissues according to GTEx for TMIGD2 Gene

This gene is overexpressed in Whole Blood (x24.9) and Spleen (x5.4).

Protein differential expression in normal tissues from HIPED for TMIGD2 Gene

This gene is overexpressed in CD8 Tcells (51.9) and NK cells (17.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TMIGD2 Gene

SOURCE GeneReport for Unigene cluster for TMIGD2 Gene Hs.263928

mRNA Expression by UniProt/SwissProt for TMIGD2 Gene

Tissue specificity: Widely expressed, mainly by epithelial and endothelial cells, including bronchial epithelial cells of lung, breast glandular and lobular epithelia cells, urothelium of the bladder, skin epidermis, epithelium of gastrointestinal, rectum, endometrial glands of the uterus, ureter, fallopian tube epithelium, colonic epithelium, small bowl epithelium, stomach epithelium, including both chief and parietal cells, trophoblastic epithelium of placenta, and pancreatic acinar cells (at protein level). Consistently expressed in veins and arteries (at protein level). Not detected in thyroid, cerebellum, cerebral cortex and thymus (at protein level). Expressed in lymphoid organs, with highest levels in thymus, spleen, peripheral blood lymphocytes and liver. In the thymus, expressed in CD4+ and CD8+ single- and double-positive cells, but not in immature CD4- and CD8- double-negative cells (at protein level). In peripheral blood mononuclear cells, highly expressed on CD56+ or CD16+ natural killer cells and CD3+ T-cells(at protein level). Not detected on B-cells(at protein level). Expressed in tonsils (at protein level).
genes like me logo Genes that share expression patterns with TMIGD2: view

Protein tissue co-expression partners for TMIGD2 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for TMIGD2 Gene

Orthologs for TMIGD2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TMIGD2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TMIGD2 35
  • 71.93 (n)
  • 59.02 (a)
  • 53 (a)
(Pan troglodytes)
Mammalia TMIGD2 35
  • 98.7 (n)
  • 96.81 (a)
  • 97 (a)
(Monodelphis domestica)
Mammalia TMIGD2 36
  • 33 (a)
Species with no ortholog for TMIGD2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TMIGD2 Gene

Gene Tree for TMIGD2 (if available)
Gene Tree for TMIGD2 (if available)

Paralogs for TMIGD2 Gene

No data available for Paralogs for TMIGD2 Gene

Variants for TMIGD2 Gene

Sequence variations from dbSNP and Humsavar for TMIGD2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs28477168 - 4,292,844(+) TGGGG(A/C/G/T)CCCCC reference, missense
rs58237134 - 4,294,626(+) CACCC(A/C)ACACG reference, missense
rs12977100 -- 4,294,545(+) CACCT(C/T)CTCCG intron-variant
rs7408794 -- 4,300,409(+) aaaat(G/T)agctg intron-variant
rs8099850 -- 4,294,359(+) aattt(G/T)taatt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMIGD2 Gene

Variant ID Type Subtype PubMed ID
nsv910817 CNV Loss 21882294
nsv833717 CNV Loss 17160897
nsv833718 CNV Loss 17160897
nsv910820 CNV Gain 21882294
dgv3674n71 CNV Loss 21882294
esv2718004 CNV Deletion 23290073
esv2677475 CNV Deletion 23128226
dgv3675n71 CNV Loss 21882294

Variation tolerance for TMIGD2 Gene

Residual Variation Intolerance Score: 95.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.30; 70.48% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TMIGD2 Gene

Disorders for TMIGD2 Gene

Relevant External Links for TMIGD2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TMIGD2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMIGD2 Gene

Publications for TMIGD2 Gene

  1. B7-H5 costimulates human T cells via CD28H. (PMID: 23784006) Zhu Y. … Chen L. (Nat Commun 2013) 2 3 4 67
  2. Identification of IGPR-1 as a novel adhesion molecule involved in angiogenesis. (PMID: 22419821) Rahimi N. … Meyer R.D. (Mol. Biol. Cell 2012) 2 3
  3. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PMID: 23824909) Chen Y. … Ge F. (Mol. Cell Proteomics 2013) 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3

Products for TMIGD2 Gene

Sources for TMIGD2 Gene