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Aliases for TMIGD2 Gene

Aliases for TMIGD2 Gene

  • IGPR1 3 4 6
  • Transmembrane And Immunoglobulin Domain Containing 2 2 3
  • Immunoglobulin And Proline-Rich Receptor 1 3 4
  • CD28 Homolog 3 4
  • IGPR-1 3 4
  • Transmembrane And Immunoglobulin Domain-Containing Protein 2 Variant 2 3
  • Transmembrane And Immunoglobulin Domain-Containing Protein 2 Variant 3 3
  • Transmembrane And Immunoglobulin Domain-Containing Protein 2 3
  • Immunoglobulin-Containing And Proline-Rich Receptor 1 3
  • CD28H 4

External Ids for TMIGD2 Gene

Summaries for TMIGD2 Gene

GeneCards Summary for TMIGD2 Gene

TMIGD2 is a Protein Coding gene.

UniProtKB/Swiss-Prot for TMIGD2 Gene

  • Plays a role in cell-cell interaction, cell migration, and angiogenesis. Through interaction with HHLA2, costimulates T-cells in the context of TCR-mediated activation. Enhances T-cell proliferation and cytokine production via an AKT-dependent signaling cascade.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMIGD2 Gene

Genomics for TMIGD2 Gene

Genomic Location for TMIGD2 Gene

Start:
4,292,227 bp from pter
End:
4,302,431 bp from pter
Size:
10,205 bases
Orientation:
Minus strand

Genomic View for TMIGD2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMIGD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMIGD2 Gene

Regulatory Elements for TMIGD2 Gene

Proteins for TMIGD2 Gene

  • Protein details for TMIGD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96BF3-TMIG2_HUMAN
    Recommended name:
    Transmembrane and immunoglobulin domain-containing protein 2
    Protein Accession:
    Q96BF3
    Secondary Accessions:
    • Q6UW59

    Protein attributes for TMIGD2 Gene

    Size:
    282 amino acids
    Molecular mass:
    30675 Da
    Quaternary structure:
    • May form homophilic interactions that could regulate cell-cell interaction. Interacts with CACNB2, DST, MIA and NCKIPSD. Interacts with HHLA2.

    Alternative splice isoforms for TMIGD2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMIGD2 Gene

Proteomics data for TMIGD2 Gene at MOPED

Post-translational modifications for TMIGD2 Gene

Other Protein References for TMIGD2 Gene

No data available for DME Specific Peptides for TMIGD2 Gene

Domains for TMIGD2 Gene

Gene Families for TMIGD2 Gene

HGNC:
  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing

Protein Domains for TMIGD2 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

TMIG2_HUMAN
Domain:
  • Contains 1 Ig-like (immunoglobulin-like) domain.:
    • Q96BF3
genes like me logo Genes that share domains with TMIGD2: view

Function for TMIGD2 Gene

Molecular function for TMIGD2 Gene

UniProtKB/Swiss-Prot Function: Plays a role in cell-cell interaction, cell migration, and angiogenesis. Through interaction with HHLA2, costimulates T-cells in the context of TCR-mediated activation. Enhances T-cell proliferation and cytokine production via an AKT-dependent signaling cascade.

Gene Ontology (GO) - Molecular Function for TMIGD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 23784006
GO:0015026 coreceptor activity IDA 23784006
genes like me logo Genes that share ontologies with TMIGD2: view

Phenotypes for TMIGD2 Gene

GenomeRNAi human phenotypes for TMIGD2:
genes like me logo Genes that share phenotypes with TMIGD2: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TMIGD2 Gene

Localization for TMIGD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMIGD2 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMIGD2 Gene COMPARTMENTS Subcellular localization image for TMIGD2 gene
Compartment Confidence
plasma membrane 5
extracellular 3
cytosol 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TMIGD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMIGD2: view

Pathways for TMIGD2 Gene

SuperPathways for TMIGD2 Gene

No Data Available

Interacting Proteins for TMIGD2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000301272%0d%0a9606.ENSP00000358081%0d%0a
Selected Interacting proteins: ENSP00000301272 for TMIGD2 Gene via STRING

Symbol External ID(s) Details
BAG3

Gene Ontology (GO) - Biological Process for TMIGD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001819 positive regulation of cytokine production IDA 23784006
GO:0007165 signal transduction IDA 23784006
GO:0031295 T cell costimulation IDA 23784006
GO:0042104 positive regulation of activated T cell proliferation IDA 23784006
GO:0045766 positive regulation of angiogenesis IMP 22419821
genes like me logo Genes that share ontologies with TMIGD2: view

No data available for Pathways by source for TMIGD2 Gene

Transcripts for TMIGD2 Gene

mRNA/cDNA for TMIGD2 Gene

(3) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMIGD2 Gene

Transmembrane and immunoglobulin domain containing 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMIGD2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5
SP1:
SP2: -

Relevant External Links for TMIGD2 Gene

GeneLoc Exon Structure for
TMIGD2
ECgene alternative splicing isoforms for
TMIGD2

Expression for TMIGD2 Gene

mRNA expression in normal human tissues for TMIGD2 Gene

mRNA differential expression in normal tissues according to GTEx for TMIGD2 Gene

This gene is overexpressed in Whole Blood (24.9) and Spleen (5.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TMIGD2 Gene

SOURCE GeneReport for Unigene cluster for TMIGD2 Gene Hs.263928

mRNA Expression by UniProt/SwissProt for TMIGD2 Gene

Q96BF3-TMIG2_HUMAN
Tissue specificity: Widely expressed, mainly by epithelial and endothelial cells, including bronchial epithelial cells of lung, breast glandular and lobular epithelia cells, urothelium of the bladder, skin epidermis, epithelium of gastrointestinal, rectum, endometrial glands of the uterus, ureter, fallopian tube epithelium, colonic epithelium, small bowl epithelium, stomach epithelium, including both chief and parietal cells, trophoblastic epithelium of placenta, and pancreatic acinar cells (at protein level). Consistently expressed in veins and arteries (at protein level). Not detected in thyroid, cerebellum, cerebral cortex and thymus (at protein level). Expressed in lymphoid organs, with highest levels in thymus, spleen, peripheral blood lymphocytes and liver. In the thymus, expressed in CD4+ and CD8+ single- and double-positive cells, but not in immature CD4- and CD8- double-negative cells (at protein level). In peripheral blood mononuclear cells, highly expressed on CD56+ or CD16+ natural killer cells and CD3+ T-cells(at protein level). Not detected on B-cells(at protein level). Expressed in tonsils (at protein level).
genes like me logo Genes that share expressions with TMIGD2: view

Orthologs for TMIGD2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TMIGD2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMIGD2 36
  • 98.7 (n)
  • 96.81 (a)
TMIGD2 37
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMIGD2 36
  • 71.93 (n)
  • 59.02 (a)
TMIGD2 37
  • 53 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMIGD2 37
  • 33 (a)
OneToOne
Species with no ortholog for TMIGD2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TMIGD2 Gene

ENSEMBL:
Gene Tree for TMIGD2 (if available)
TreeFam:
Gene Tree for TMIGD2 (if available)

Paralogs for TMIGD2 Gene

No data available for Paralogs for TMIGD2 Gene

Variants for TMIGD2 Gene

Sequence variations from dbSNP and Humsavar for TMIGD2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs888932 -- 4,292,600(+) TCTCT(C/T)ACTCC synonymous-codon, reference
rs888933 -- 4,302,507(+) TCCAG(C/G)CTGCT upstream-variant-2KB
rs918484 -- 4,301,848(+) AAAGT(C/T)TGCTT intron-variant
rs2380179 -- 4,291,852(+) TCCCC(C/T)CTCAG downstream-variant-500B
rs2380180 -- 4,293,491(+) tcctg(A/G)cctcg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMIGD2 Gene

Variant ID Type Subtype PubMed ID
nsv910817 CNV Loss 21882294
nsv833717 CNV Loss 17160897
nsv833718 CNV Loss 17160897
nsv910820 CNV Gain 21882294
dgv3674n71 CNV Loss 21882294
esv2718004 CNV Deletion 23290073
esv2677475 CNV Deletion 23128226
dgv3675n71 CNV Loss 21882294

Relevant External Links for TMIGD2 Gene

HapMap Linkage Disequilibrium report
TMIGD2

Disorders for TMIGD2 Gene

No disorders were found for TMIGD2 Gene.

No data available for UniProtKB/Swiss-Prot for TMIGD2 Gene

Publications for TMIGD2 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Identification of IGPR-1 as a novel adhesion molecule involved in angiogenesis. (PMID: 22419821) Rahimi N. … Meyer R.D. (Mol. Biol. Cell 2012) 3 4
  4. B7-H5 costimulates human T cells via CD28H. (PMID: 23784006) Zhu Y. … Chen L. (Nat Commun 2013) 3 4
  5. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PMID: 23824909) Chen Y. … Ge F. (Mol. Cell Proteomics 2013) 3

Products for TMIGD2 Gene

Sources for TMIGD2 Gene

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