TMIGD2 Gene
protein-coding GIFtS: 40
GCID: GC19M004292
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transmembrane and immunoglobulin domain containing 2
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Aliases
for TMIGD2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Transmembrane And Immunoglobulin Domain Containing 21 2 | | Immunoglobulin-Containing And Proline-Rich Receptor 12 | | Immunoglobulin And Proline-Rich Receptor 12 3 | | Transmembrane And Immunoglobulin Domain-Containing Protein 22 | | IGPR-12 3 | | Transmembrane And Immunoglobulin Domain-Containing Protein 2 Variant 22 | | IGPR12 3 | | Transmembrane And Immunoglobulin Domain-Containing Protein 2 Variant 32 | | MGC232441 | | |
Export aliases for TMIGD2 gene to outside databasesPrevious GC identifers: GC19M004244 GC19M004055 |
Summaries
for TMIGD2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: TMIG2_HUMAN, Q96BF3Function: Plays a role in cell-cell interaction, cell migration, and angiogenesis
|
Genomic Views
for TMIGD2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011255.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TMIGD2 gene promoter:
Elk-1 RFX1 CUTL1 POU3F2 (N-Oct-5a) POU3F2 (N-Oct-5b) Tal-1beta POU3F2 c-Ets-1 GATA-2 ITF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for TMIGD2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMIGD2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.3 Ensembl cytogenetic band: 19p13.3 HGNC cytogenetic band: 19p13.3TMIGD2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M004292: view genomic region
(about GC identifiers)
Start:
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4,292,224 bp from pter |
End:
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4,302,428 bp from pter |
Size:
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10,205 bases |
Orientation:
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minus strand |
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Proteins
for TMIGD2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TMIG2_HUMAN, Q96BF3 (See
protein sequence)Recommended Name: Transmembrane and immunoglobulin domain-containing protein 2 precursor Size: 282 amino acids; 30675 Da
Subunit: May form homophilic interactions that could regulate cell-cell interaction. Interacts with CACNB2, DST, MIAand NCKIPSD
Subcellular location: Cell membrane; Single-pass type I membrane protein
Secondary accessions: Q6UW59Alternative splicing: 2 isoforms: Q96BF3-1 Q96BF3-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for TMIGD2: NX_Q96BF3
Post-translational modifications:
N-glycosylated1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96BF3
TMIGD2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001162597.1 NP_653216.2
ENSEMBL proteins: ENSP00000301272
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005886 | plasma membrane |
IEA | -- | | GO:0016021 | integral to membrane |
IEA | -- |
TMIGD2 for ontologies About GeneDecksing
TMIGD2 Antibody Products:
Assay Products for TMIGD2: |
Protein
Domains /
Families
for TMIGD2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TMIGD2 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96BF3ProtoNet protein and cluster: Q96BF3 UniProtKB/Swiss-Prot: TMIG2_HUMAN, Q96BF3Similarity: Contains 1 Ig-like (immunoglobulin-like) domain |
Function
for TMIGD2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TMIG2_HUMAN, Q96BF3Function: Plays a role in cell-cell interaction, cell migration, and angiogenesis
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMIGD2 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMIGD2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMIGD2 |
1 GenomeRNAi human phenotype for TMIGD2:
|
Pathways & Interactions
for TMIGD2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMIGD2
|
Drugs & Compounds
for TMIGD2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TMIGD2
Search CenterWatch for drugs/clinical trials and news about TMIGD2 / TMIG2
|
Transcripts
for TMIGD2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TMIGD2 gene (2 alternative transcripts): NM_001169126.1 NM_144615.2 Unigene Cluster for TMIGD2: Transmembrane and immunoglobulin domain containing 2 Hs.263928 [show with all ESTs]Unigene Representative Sequence: NM_1446151 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000301272(uc010dtv.2 uc002lzx.2 uc021umz.1 uc021una.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMIGD2 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMIGD2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): TMIGD2 (NM_001169126) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMIGD2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMIGD2 |
Additional cDNA sequence: AY358964.1 BC015655.1 HQ452865.1 HQ452866.1 1 DOTS entry: DT.70102688 12 AceView cDNA sequences: BC015655 BI838355 AY358964 NM_144615 AI470431 BI551317 AI470437 BG774582 AW063767 BU629751 AI817976 AA905516
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for TMIGD2 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 |
|---|
|
| SP1: | | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | | |
ECgene alternative splicing isoforms for TMIGD2
|
Expression
for TMIGD2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TMIGD2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See TMIGD2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TMIGD2
SOURCE GeneReport for Unigene cluster: Hs.263928
UniProtKB/Swiss-Prot: TMIG2_HUMAN, Q96BF3Tissue specificity: Widely expressed, mainly by epithelial and endothelial cells, including bronchial epithelial cellsof lung, breast glandular and lobular epithelia cells, urothelium of the bladder, skin epidermis, epithelium ofgastrointestinal, rectum, endometrial glands of the uterus, ureter, fallopian tube epithelium, colonic epithelium,small bowl epithelium, stomach epithelium, including both chief and parietal cells, trophoblastic epithelium ofplacenta, and pancreatic acinar cells (at protein level). Consistently expressed in veins and arteries (at proteinlevel). Not detected in thyroid, cerebellum, cerebral cortex and thymus (at protein level)
SABiosciences Custom PCR Arrays for TMIGD2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMIGD2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat TMIGD2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMIGD2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMIGD2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMIGD2 |
Orthologs
for TMIGD2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for TMIGD2 (if available)
TreeFam Gene Tree for TMIGD2 (if available) |
Paralogs
for TMIGD2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for TMIGD2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TMIGD2 (4292224 - 4302428 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TMIGD2: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMIGD2 |
|
Disorders
/ Diseases
for TMIGD2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TMIGD2 for disorders About GeneDecksing
OMIM gene information: 614715
OMIM disorders: --
1  disease for TMIGD2: About MalaCardsbullous pemphigoid
Export disorders for TMIGD2 gene to outside databases
|
Publications
for TMIGD2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TMIGD2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TMIGD2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of IGPR-1 as a novel adhesion molecule involved in angiogenesis. (PubMed id 22419821)1, 2 Rahimi N....Meyer R.D. (2012)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
- Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)2 Zhang Z. and Henzel W.J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for TMIGD2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TMIGD2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TMIGD2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TMIGD2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TMIGD2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TMIGD2 gene:
Search GeneIP for patents involving TMIGD2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TMIGD2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TMIGD2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMIGD2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMIGD2 | | | OriGene Protein Over-expression Lysate for TMIGD2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TMIGD2 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMIGD2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMIGD2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for TMIGD2 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TMIGD2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMIGD2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMIGD2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMIGD2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMIGD2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMIGD2 |
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 | | | TMIGD2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMIGD2 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMIGD2 |
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