TMIGD1 Gene
protein-coding GIFtS: 36
GCID: GC17M028643
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transmembrane and immunoglobulin domain containing 1
(Previous symbol: TMIGD)
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Aliases
for TMIGD1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Transmembrane And Immunoglobulin Domain Containing 11 2 | | TMIGD1 2 3 | | UNQ93721 2 | | AWKS93722 | | Transmembrane And Immunoglobulin Domain-Containing Protein 12 |
Export aliases for TMIGD1 gene to outside databasesPrevious GC identifers: GC17M025669 GC17M024853 |
Summaries
for TMIGD1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for TMIGD1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010799.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TMIGD1 gene promoter:
TBP E2F-3a E2F-4 E2F-5 AML1a E2F-2 SRY E2F-1 E2F
Other transcription factors
Search SABiosciences Chromatin IP Primers for TMIGD1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMIGD1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q11.2 Ensembl cytogenetic band: 17q11.2 HGNC cytogenetic band: 17q11.2TMIGD1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M028643: view genomic region
(about GC identifiers)
Start:
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28,643,351 bp from pter |
End:
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28,661,077 bp from pter |
Size:
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17,727 bases |
Orientation:
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minus strand |
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Proteins
for TMIGD1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TMIG1_HUMAN, Q6UXZ0 (See
protein sequence)Recommended Name: Transmembrane and immunoglobulin domain-containing protein 1 precursor Size: 262 amino acids; 29185 Da
Subcellular location: Membrane; Single-pass type I membrane protein (Potential)
Secondary accessions: A8K2K1 Q6ZMC6Alternative splicing: 2 isoforms: Q6UXZ0-1 Q6UXZ0-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for TMIGD1: NX_Q6UXZ0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6UXZ0
TMIGD1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_996663.1
ENSEMBL proteins: ENSP00000446118 ENSP00000332404
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
TMIGD1 for ontologies About GeneDecksing
TMIGD1 Antibody Products:
Assay Products for TMIGD1: |
Protein
Domains /
Families
for TMIGD1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TMIGD1 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q6UXZ0ProtoNet protein and cluster: Q6UXZ0 2 Blocks protein families: IPB003598 Immunoglobulin C-2 type IPB003599 Immunoglobulin subtype
UniProtKB/Swiss-Prot: TMIG1_HUMAN, Q6UXZ0Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains |
Function
for TMIGD1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMIGD1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMIGD1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TMIGD1 (NM_206832) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMIGD1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMIGD1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMIGD1 |
|
Pathways & Interactions
for TMIGD1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMIGD1
|
Drugs & Compounds
for TMIGD1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TMIGD1
Search CenterWatch for drugs/clinical trials and news about TMIGD1 / TMIG1
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Transcripts
for TMIGD1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TMIGD1 gene: NM_206832.1 Unigene Cluster for TMIGD1: Transmembrane and immunoglobulin domain containing 1 Hs.371005 [show with all ESTs]Unigene Representative Sequence: AY3581532 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000538566(uc010csh.1) ENST00000328886(uc002hfa.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMIGD1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMIGD1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TMIGD1 (NM_206832) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMIGD1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMIGD1 |
Additional cDNA sequence: AK172838.1 AK290266.1 AY358153.1 BC137201.1 BC137202.1 2 DOTS entries: DT.40273094 DT.102820426 6 AceView cDNA sequences: AK172838 NM_206832 AY358153 BI764721 AW235098 AI634028
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for TMIGD1 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b |
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| SP1: | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | - | | | | | | | |
ECgene alternative splicing isoforms for TMIGD1
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Expression
for TMIGD1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TMIGD1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See TMIGD1 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.371005
SABiosciences Custom PCR Arrays for TMIGD1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMIGD1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TMIGD1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMIGD1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMIGD1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMIGD1 |
Orthologs
for TMIGD1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of chordates.
Orthologs for TMIGD1 gene from 4/10 species (see all 10) About this table
ENSEMBL Gene Tree for TMIGD1 (if available)
TreeFam Gene Tree for TMIGD1 (if available) |
Paralogs
for TMIGD1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for TMIGD1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TMIGD1 (28643351 - 28661077 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TMIGD1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMIGD1 |
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Disorders
/ Diseases
for TMIGD1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for TMIGD1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TMIGD1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TMIGD1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2, 3 Clark H.F.... Gray A.M. (2003)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for TMIGD1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing TMIGD1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TMIGD1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TMIGD1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TMIGD1 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for TMIGD1 gene:
Search GeneIP for patents involving TMIGD1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TMIGD1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TMIGD1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMIGD1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMIGD1 | | | OriGene Protein Over-expression Lysate for TMIGD1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TMIGD1 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMIGD1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMIGD1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for TMIGD1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TMIGD1 | | OriGene Custom Protein Services for TMIGD1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TMIGD1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMIGD1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMIGD1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMIGD1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMIGD1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMIGD1 |
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 |  |  |  | |
| | | | Search Tocris compounds for TMIGD1 |
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 | | | TMIGD1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMIGD1 |
|  |  |  | | | | Search ThermoFisher Antibodies for TMIGD1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMIGD1 |
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