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Aliases for TMIGD1 Gene

Aliases for TMIGD1 Gene

  • Transmembrane And Immunoglobulin Domain Containing 1 2 3 5
  • TMIGD 3 4
  • Transmembrane And Immunoglobulin Domain-Containing Protein 1 3
  • AWKS9372 3
  • UNQ9372 3

External Ids for TMIGD1 Gene

Previous HGNC Symbols for TMIGD1 Gene

  • TMIGD

Previous GeneCards Identifiers for TMIGD1 Gene

  • GC17M025669
  • GC17M028643
  • GC17M024853

Summaries for TMIGD1 Gene

GeneCards Summary for TMIGD1 Gene

TMIGD1 (Transmembrane And Immunoglobulin Domain Containing 1) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMIGD1 Gene

Genomics for TMIGD1 Gene

Regulatory Elements for TMIGD1 Gene

Enhancers for TMIGD1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G030376 1.4 Ensembl ENCODE 10.7 -44.4 -44375 4.8 HDGF PKNOX1 FOXA2 ARNT WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 LRRC37BP1 SUZ12P1 ENSG00000265791 CORO6 TMIGD1 SMURF2P1 BLMH RNU6-1267P GOSR1 TBC1D29
GH17G030270 1.1 ENCODE 11.3 +62.3 62251 1.9 HDGF PKNOX1 CREB3L1 AGO1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 BLMH ENSG00000252112 NUFIP2 TMIGD1 ATAD5 SLC6A4 NSRP1 SH3GL1P2 TEFM LRRC37BP1
GH17G030116 1.1 ENCODE 11.1 +216.6 216634 2.6 PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 FOS ZNF263 CORO6 SLC6A4 NUFIP2 RNF135 ENSG00000252112 ENSG00000264456 TMIGD1 BLMH RNU6-1267P MIR3184
GH17G030389 1.1 FANTOM5 Ensembl 11 -55.9 -55936 0.5 KLF1 ZNF777 SIN3A ZNF335 ZNF121 GLIS2 ZFHX2 ZBTB48 POLR2A ZNF600 TMIGD1 NSRP1 CPD SSH2 GOSR1 GC17P030389 GC17P030463
GH17G030222 1.1 Ensembl ENCODE 9.9 +111.0 110970 1.8 TBP PKNOX1 ARID4B DMAP1 RAD21 ZNF143 ZNF207 ETV6 RELB IKZF2 CORO6 ENSG00000252112 RNU6-1267P BLMH TMIGD1 SUZ12P1 GC17P030227 ENSG00000264125
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMIGD1 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMIGD1 Gene

Chromosome:
17
Start:
30,316,329 bp from pter
End:
30,334,076 bp from pter
Size:
17,748 bases
Orientation:
Minus strand

Genomic View for TMIGD1 Gene

Genes around TMIGD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMIGD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMIGD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMIGD1 Gene

Proteins for TMIGD1 Gene

  • Protein details for TMIGD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UXZ0-TMIG1_HUMAN
    Recommended name:
    Transmembrane and immunoglobulin domain-containing protein 1
    Protein Accession:
    Q6UXZ0
    Secondary Accessions:
    • A8K2K1
    • Q6ZMC6

    Protein attributes for TMIGD1 Gene

    Size:
    262 amino acids
    Molecular mass:
    29185 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMIGD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMIGD1 Gene

Post-translational modifications for TMIGD1 Gene

  • Glycosylation at Asn58, Asn83, Asn118, posLast=158158, and isoforms=2190
  • Modification sites at PhosphoSitePlus

Other Protein References for TMIGD1 Gene

No data available for DME Specific Peptides for TMIGD1 Gene

Domains & Families for TMIGD1 Gene

Suggested Antigen Peptide Sequences for TMIGD1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMIGD1: view

No data available for UniProtKB/Swiss-Prot for TMIGD1 Gene

Function for TMIGD1 Gene

genes like me logo Genes that share phenotypes with TMIGD1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TMIGD1

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMIGD1 Gene

Localization for TMIGD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMIGD1 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMIGD1 gene
Compartment Confidence
plasma membrane 3
extracellular 2
mitochondrion 2
cytosol 2

Gene Ontology (GO) - Cellular Components for TMIGD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMIGD1: view

Pathways & Interactions for TMIGD1 Gene

SuperPathways for TMIGD1 Gene

No Data Available

Interacting Proteins for TMIGD1 Gene

Selected Interacting proteins: Q6UXZ0-TMIG1_HUMAN for TMIGD1 Gene via IID

Symbol External ID(s) Details
NID1

Gene Ontology (GO) - Biological Process for TMIGD1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMIGD1 Gene

Drugs & Compounds for TMIGD1 Gene

No Compound Related Data Available

Transcripts for TMIGD1 Gene

mRNA/cDNA for TMIGD1 Gene

(3) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMIGD1 Gene

Transmembrane and immunoglobulin domain containing 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMIGD1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP1:
SP2: -

Relevant External Links for TMIGD1 Gene

GeneLoc Exon Structure for
TMIGD1
ECgene alternative splicing isoforms for
TMIGD1

Expression for TMIGD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMIGD1 Gene

mRNA differential expression in normal tissues according to GTEx for TMIGD1 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x27.2) and Colon - Transverse (x24.9).

Protein differential expression in normal tissues from HIPED for TMIGD1 Gene

This gene is overexpressed in Breast (66.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMIGD1 Gene



Protein tissue co-expression partners for TMIGD1 Gene

NURSA nuclear receptor signaling pathways regulating expression of TMIGD1 Gene:

TMIGD1

SOURCE GeneReport for Unigene cluster for TMIGD1 Gene:

Hs.371005

Evidence on tissue expression from TISSUES for TMIGD1 Gene

  • Intestine(4.4)
genes like me logo Genes that share expression patterns with TMIGD1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMIGD1 Gene

Orthologs for TMIGD1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMIGD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMIGD1 34 35
  • 99.49 (n)
dog
(Canis familiaris)
Mammalia TMIGD1 34 35
  • 86.85 (n)
cow
(Bos Taurus)
Mammalia TMIGD1 34 35
  • 83.91 (n)
rat
(Rattus norvegicus)
Mammalia Tmigd1 34
  • 81.32 (n)
mouse
(Mus musculus)
Mammalia Tmigd1 34 16 35
  • 78.54 (n)
oppossum
(Monodelphis domestica)
Mammalia TMIGD1 35
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMIGD1 35
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMIGD1 34 35
  • 60.82 (n)
lizard
(Anolis carolinensis)
Reptilia TMIGD1 35
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmigd1 34
  • 54.39 (n)
zebrafish
(Danio rerio)
Actinopterygii tmigd1 34 35
  • 50.24 (n)
Species where no ortholog for TMIGD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMIGD1 Gene

ENSEMBL:
Gene Tree for TMIGD1 (if available)
TreeFam:
Gene Tree for TMIGD1 (if available)

Paralogs for TMIGD1 Gene

No data available for Paralogs for TMIGD1 Gene

Variants for TMIGD1 Gene

Sequence variations from dbSNP and Humsavar for TMIGD1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000057764 -- 30,317,453(+) TATTT(A/G)CTTTT intron-variant
rs1000108243 -- 30,317,709(+) GAGCT(-/GAG)ATCAC intron-variant
rs1000297573 -- 30,324,333(+) AAAGG(A/G)CTTTT intron-variant
rs1000595539 -- 30,335,073(+) ACCCT(C/T)CCTAC upstream-variant-2KB
rs1000615328 -- 30,322,452(+) AAGCC(A/C)GATAA intron-variant

Variation tolerance for TMIGD1 Gene

Residual Variation Intolerance Score: 51.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.18; 23.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMIGD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMIGD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TMIGD1 Gene

Disorders for TMIGD1 Gene

Relevant External Links for TMIGD1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMIGD1

No disorders were found for TMIGD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMIGD1 Gene

Publications for TMIGD1 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4 64
  2. TMIGD1 is a novel adhesion molecule that protects epithelial cells from oxidative cell injury. (PMID: 26342724) Arafa E. … Rahimi N. (Am. J. Pathol. 2015) 2 3 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for TMIGD1 Gene

Sources for TMIGD1 Gene

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