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Aliases for TMF1 Gene

Aliases for TMF1 Gene

  • Androgen Receptor-Associated Protein Of 160 KDa 3 4
  • Androgen Receptor Coactivator 160 KDa Protein 3 4
  • TATA Element Modulatory Factor 1 2 3
  • ARA160 3 4
  • TMF 3 4
  • TATA Element Modulatory Factor 3

External Ids for TMF1 Gene

Summaries for TMF1 Gene

GeneCards Summary for TMF1 Gene

TMF1 is a Protein Coding gene. Among its related pathways are Coregulation of Androgen receptor activity. GO annotations related to this gene include transcription cofactor activity.

UniProtKB/Swiss-Prot for TMF1 Gene

  • Potential coactivator of the androgen receptor. Mediates STAT3 degradation. May play critical roles in two RAB6-dependent retrograde transport processes: one from endosomes to the Golgi and the other from the Golgi to the ER. This protein binds the HIV-1 TATA element and inhibits transcriptional activation by the TATA-binding protein (TBP).

Gene Wiki entry for TMF1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMF1 Gene

Genomics for TMF1 Gene

Genomic Location for TMF1 Gene

Start:
69,019,827 bp from pter
End:
69,052,333 bp from pter
Size:
32,507 bases
Orientation:
Minus strand

Genomic View for TMF1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMF1 Gene

Regulatory Elements for TMF1 Gene

Proteins for TMF1 Gene

  • Protein details for TMF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P82094-TMF1_HUMAN
    Recommended name:
    TATA element modulatory factor
    Protein Accession:
    P82094
    Secondary Accessions:
    • B7ZLJ2
    • Q17R87
    • Q59GK0

    Protein attributes for TMF1 Gene

    Size:
    1093 amino acids
    Molecular mass:
    122842 Da
    Quaternary structure:
    • Interacts with TRNP1; may regulate TRNP1 proteasomal degradation (By similarity). Component of the SNF/SWI transcription factor complexes. Interacts with RAB6A. Interacts with STAT3 and FER. Interacts with TCEB1.
    SequenceCaution:
    • Sequence=AAD54608.1; Type=Frameshift; Positions=969, 971, 975, 985; Evidence={ECO:0000305}; Sequence=BAD92346.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TMF1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMF1 Gene

Proteomics data for TMF1 Gene at MOPED

Post-translational modifications for TMF1 Gene

Other Protein References for TMF1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMF1 Gene

Domains for TMF1 Gene

Protein Domains for TMF1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMF1 Gene

Graphical View of Domain Structure for InterPro Entry

P82094

UniProtKB/Swiss-Prot:

TMF1_HUMAN
Domain:
  • The Elongin BC complex binding domain is also known as BC-box with the consensus [APST]-L-x(3)-C-x(3)-[AILV]:
    • P82094
genes like me logo Genes that share domains with TMF1: view

No data available for Gene Families for TMF1 Gene

Function for TMF1 Gene

Molecular function for TMF1 Gene

GENATLAS Biochemistry: TATA element modulatory factor (123kDa),with leucine zipper motif
UniProtKB/Swiss-Prot Function: Potential coactivator of the androgen receptor. Mediates STAT3 degradation. May play critical roles in two RAB6-dependent retrograde transport processes: one from endosomes to the Golgi and the other from the Golgi to the ER. This protein binds the HIV-1 TATA element and inhibits transcriptional activation by the TATA-binding protein (TBP).
UniProtKB/Swiss-Prot Induction: Down-regulated in malignant brain tumors.

Gene Ontology (GO) - Molecular Function for TMF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003712 transcription cofactor activity TAS 10428808
GO:0005515 protein binding IPI 20195357
genes like me logo Genes that share ontologies with TMF1: view

Phenotypes for TMF1 Gene

genes like me logo Genes that share phenotypes with TMF1: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TMF1 Gene

Localization for TMF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMF1 Gene

Cytoplasm. Nucleus. Golgi apparatus membrane. Note=Concentrated at the budding structures localized at the tips of cisternae.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMF1 Gene COMPARTMENTS Subcellular localization image for TMF1 gene
Compartment Confidence
golgi apparatus 5
nucleus 5
cytosol 1

Gene Ontology (GO) - Cellular Components for TMF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005634 nucleus IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005794 Golgi apparatus IDA --
GO:0016020 membrane --
genes like me logo Genes that share ontologies with TMF1: view

Pathways for TMF1 Gene

genes like me logo Genes that share pathways with TMF1: view

Pathways by source for TMF1 Gene

1 BioSystems pathway for TMF1 Gene

Gene Ontology (GO) - Biological Process for TMF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001675 acrosome assembly IEA --
GO:0001819 positive regulation of cytokine production IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter TAS 1409643
GO:0007286 spermatid development --
genes like me logo Genes that share ontologies with TMF1: view

Compounds for TMF1 Gene

(1) Novoseek inferred chemical compound relationships for TMF1 Gene

Compound -log(P) Hits PubMed IDs
testosterone 26.6 3
genes like me logo Genes that share compounds with TMF1: view

Transcripts for TMF1 Gene

Unigene Clusters for TMF1 Gene

TATA element modulatory factor 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMF1 Gene

No ASD Table

Relevant External Links for TMF1 Gene

GeneLoc Exon Structure for
TMF1
ECgene alternative splicing isoforms for
TMF1

Expression for TMF1 Gene

mRNA expression in normal human tissues for TMF1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TMF1 Gene

SOURCE GeneReport for Unigene cluster for TMF1 Gene Hs.267632

genes like me logo Genes that share expressions with TMF1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TMF1 Gene

Orthologs for TMF1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMF1 35
  • 99.51 (n)
  • 99.45 (a)
TMF1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMF1 35
  • 91.91 (n)
  • 92.67 (a)
TMF1 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMF1 35
  • 92.25 (n)
  • 93.57 (a)
TMF1 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmf1 35
  • 86 (n)
  • 87.68 (a)
Tmf1 16
Tmf1 36
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMF1 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMF1 36
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmf1 35
  • 85.35 (n)
  • 86.97 (a)
chicken
(Gallus gallus)
Aves TMF1 35
  • 75.6 (n)
  • 77.58 (a)
TMF1 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMF1 36
  • 72 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii Dr.14269 35
tmf1 35
  • 63.37 (n)
  • 63.56 (a)
tmf1 36
  • 58 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG4557 36
  • 27 (a)
OneToOne
Species with no ortholog for TMF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMF1 Gene

ENSEMBL:
Gene Tree for TMF1 (if available)
TreeFam:
Gene Tree for TMF1 (if available)

Paralogs for TMF1 Gene

Pseudogenes.org Pseudogenes for TMF1 Gene

genes like me logo Genes that share paralogs with TMF1: view

No data available for Paralogs for TMF1 Gene

Variants for TMF1 Gene

Sequence variations from dbSNP and Humsavar for TMF1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs1745 -- 69,021,306(+) GTCTT(A/G)GAACG utr-variant-3-prime
rs15780 -- 69,021,248(+) GGAAA(A/C)AACAG utr-variant-3-prime
rs937858 -- 69,033,722(-) GACTT(A/C)AGAAT intron-variant
rs937859 -- 69,033,506(-) CTTCC(A/G)TCTTG intron-variant
rs1044302 -- 69,020,190(-) AATTT(A/T)TTTTC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TMF1 Gene

Variant ID Type Subtype PubMed ID
nsv876933 CNV Loss 21882294

Relevant External Links for TMF1 Gene

HapMap Linkage Disequilibrium report
TMF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMF1 Gene

Disorders for TMF1 Gene

(1) University of Copenhagen DISEASES for TMF1 Gene

(1) Novoseek inferred disease relationships for TMF1 Gene

Disease -log(P) Hits PubMed IDs
prostate cancer 24 1

Relevant External Links for TMF1

Genetic Association Database (GAD)
TMF1
Human Genome Epidemiology (HuGE) Navigator
TMF1
genes like me logo Genes that share disorders with TMF1: view

No data available for UniProtKB/Swiss-Prot for TMF1 Gene

Publications for TMF1 Gene

  1. Isolation and characterization of ARA160 as the first androgen receptor N-terminal-associated coactivator in human prostate cells. (PMID: 10428808) Hsiao P.W. … Chang C. (J. Biol. Chem. 1999) 3 4 23
  2. Cloning and chromosomal mapping of a human immunodeficiency virus 1 'TATA' element modulatory factor. (PMID: 1409643) Garcia J.A. … Gaynor R.B. (Proc. Natl. Acad. Sci. U.S.A. 1992) 2 3 4
  3. A putative nuclear receptor coactivator (TMF/ARA160) associates with hbrm/hSNF2 alpha and BRG-1/hSNF2 beta and localizes in the Golgi apparatus. (PMID: 12044884) Mori K. … Kato H. (FEBS Lett. 2002) 3 4
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  5. Functional involvement of TMF/ARA160 in Rab6-dependent retrograde membrane traffic. (PMID: 17698061) Yamane J. … Tsukita S. (Exp. Cell Res. 2007) 3 4

Products for TMF1 Gene

Sources for TMF1 Gene

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