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Aliases for TMF1 Gene

Aliases for TMF1 Gene

  • TATA Element Modulatory Factor 1 2 3 5
  • Androgen Receptor-Associated Protein Of 160 KDa 3 4
  • Androgen Receptor Coactivator 160 KDa Protein 3 4
  • ARA160 3 4
  • TMF 3 4
  • TATA Element Modulatory Factor 3

External Ids for TMF1 Gene

Previous GeneCards Identifiers for TMF1 Gene

  • GC03M067611
  • GC03M068445
  • GC03M068892
  • GC03M069005
  • GC03M069155
  • GC03M069068

Summaries for TMF1 Gene

GeneCards Summary for TMF1 Gene

TMF1 (TATA Element Modulatory Factor 1) is a Protein Coding gene. Among its related pathways are Golgi-to-ER retrograde transport and Retrograde transport at the Trans-Golgi-Network. GO annotations related to this gene include transcription cofactor activity.

UniProtKB/Swiss-Prot for TMF1 Gene

  • Potential coactivator of the androgen receptor. Mediates STAT3 degradation. May play critical roles in two RAB6-dependent retrograde transport processes: one from endosomes to the Golgi and the other from the Golgi to the ER. This protein binds the HIV-1 TATA element and inhibits transcriptional activation by the TATA-binding protein (TBP).

Gene Wiki entry for TMF1 Gene

Additional gene information for TMF1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMF1 Gene

Genomics for TMF1 Gene

Regulatory Elements for TMF1 Gene

Enhancers for TMF1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03H069008 1.3 Ensembl ENCODE 27 +40.8 40753 6 ARID4B SIN3A DMAP1 ZNF766 ZNF143 SP3 MXD4 REST ZNF592 KAT8 TMF1 ENSG00000244513 UBA3 ARL6IP5 EOGT GC03P068964
GH03H069079 2 FANTOM5 Ensembl ENCODE dbSUPER 14.2 -36.2 -36196 18 HDGF PKNOX1 ARID4B SIN3A FEZF1 DMAP1 YBX1 ZNF2 YY1 ZNF766 ARL6IP5 UBA3 TMF1 EOGT LMOD3 GC03M069083
GH03H069248 1.3 Ensembl ENCODE 14 -197.1 -197102 2 PKNOX1 FOXA2 FEZF1 GLI4 ZNF2 YY1 ZNF121 KLF7 SP3 TSHZ1 ENSG00000244513 TMF1 LMOD3 RBM43P1
GH03H069997 1.4 Ensembl ENCODE dbSUPER 10.2 -947.1 -947125 3 HDAC1 TBP ATF1 RB1 ZBTB40 RCOR1 ATF7 ETV6 CREM SMAD5 SAMMSON TMF1 GC03P069839 GC03P069838
GH03H069050 1.3 ENCODE dbSUPER 7.1 +0.3 343 2 PKNOX1 FOXA2 ATF1 ARID4B SIN3A DMAP1 BRCA1 YY1 ZNF121 SLC30A9 UBA3 ARL6IP5 TMF1 MIR3136
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMF1 on UCSC Golden Path with GeneCards custom track

Promoters for TMF1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000154072 733 2401 PKNOX1 FOXA2 ATF1 ARID4B SIN3A DMAP1 BRCA1 YY1 ZNF121 SLC30A9

Genomic Location for TMF1 Gene

Chromosome:
3
Start:
69,019,827 bp from pter
End:
69,052,333 bp from pter
Size:
32,507 bases
Orientation:
Minus strand

Genomic View for TMF1 Gene

Genes around TMF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMF1 Gene

Proteins for TMF1 Gene

  • Protein details for TMF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P82094-TMF1_HUMAN
    Recommended name:
    TATA element modulatory factor
    Protein Accession:
    P82094
    Secondary Accessions:
    • B7ZLJ2
    • Q17R87
    • Q59GK0

    Protein attributes for TMF1 Gene

    Size:
    1093 amino acids
    Molecular mass:
    122842 Da
    Quaternary structure:
    • Interacts with TRNP1; may regulate TRNP1 proteasomal degradation (By similarity). Component of the SNF/SWI transcription factor complexes. Interacts with RAB6A. Interacts with STAT3 and FER. Interacts with TCEB1.
    SequenceCaution:
    • Sequence=AAD54608.1; Type=Frameshift; Positions=969, 971, 975, 985; Evidence={ECO:0000305}; Sequence=BAD92346.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TMF1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMF1 Gene

Post-translational modifications for TMF1 Gene

Other Protein References for TMF1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMF1 Gene

Domains & Families for TMF1 Gene

Gene Families for TMF1 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for TMF1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMF1 Gene

Graphical View of Domain Structure for InterPro Entry

P82094

UniProtKB/Swiss-Prot:

TMF1_HUMAN :
  • The Elongin BC complex binding domain is also known as BC-box with the consensus [APST]-L-x(3)-C-x(3)-[AILV].
Domain:
  • The Elongin BC complex binding domain is also known as BC-box with the consensus [APST]-L-x(3)-C-x(3)-[AILV].
genes like me logo Genes that share domains with TMF1: view

Function for TMF1 Gene

Molecular function for TMF1 Gene

GENATLAS Biochemistry:
TATA element modulatory factor (123kDa),with leucine zipper motif
UniProtKB/Swiss-Prot Function:
Potential coactivator of the androgen receptor. Mediates STAT3 degradation. May play critical roles in two RAB6-dependent retrograde transport processes: one from endosomes to the Golgi and the other from the Golgi to the ER. This protein binds the HIV-1 TATA element and inhibits transcriptional activation by the TATA-binding protein (TBP).
UniProtKB/Swiss-Prot Induction:
Down-regulated in malignant brain tumors.

Gene Ontology (GO) - Molecular Function for TMF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003712 transcription cofactor activity TAS 10428808
GO:0005515 protein binding IPI 20195357
genes like me logo Genes that share ontologies with TMF1: view
genes like me logo Genes that share phenotypes with TMF1: view

Animal Models for TMF1 Gene

MGI Knock Outs for TMF1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TMF1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TMF1 Gene

Localization for TMF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMF1 Gene

Cytoplasm. Nucleus. Golgi apparatus membrane. Note=Concentrated at the budding structures localized at the tips of cisternae.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMF1 gene
Compartment Confidence
nucleus 5
cytosol 5
golgi apparatus 5
endoplasmic reticulum 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TMF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005794 Golgi apparatus IEA,IDA --
genes like me logo Genes that share ontologies with TMF1: view

Pathways & Interactions for TMF1 Gene

genes like me logo Genes that share pathways with TMF1: view

Gene Ontology (GO) - Biological Process for TMF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001675 acrosome assembly IEA --
GO:0001819 positive regulation of cytokine production IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated TAS,IEA --
GO:0006366 transcription from RNA polymerase II promoter TAS 1409643
genes like me logo Genes that share ontologies with TMF1: view

No data available for SIGNOR curated interactions for TMF1 Gene

Drugs & Compounds for TMF1 Gene

(1) Drugs for TMF1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with TMF1: view

Transcripts for TMF1 Gene

Unigene Clusters for TMF1 Gene

TATA element modulatory factor 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TMF1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for TMF1 Gene

No ASD Table

Relevant External Links for TMF1 Gene

GeneLoc Exon Structure for
TMF1
ECgene alternative splicing isoforms for
TMF1

Expression for TMF1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TMF1 Gene

This gene is overexpressed in Brain (11.9), Pancreas (11.8), Adrenal (8.0), and Frontal cortex (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TMF1 Gene



Protein tissue co-expression partners for TMF1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TMF1 Gene:

TMF1

SOURCE GeneReport for Unigene cluster for TMF1 Gene:

Hs.267632

Evidence on tissue expression from TISSUES for TMF1 Gene

  • Nervous system(4.4)
  • Liver(4.3)
  • Heart(2.4)
  • Muscle(2)
genes like me logo Genes that share expression patterns with TMF1: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMF1 Gene

Orthologs for TMF1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMF1 33 34
  • 99.51 (n)
dog
(Canis familiaris)
Mammalia TMF1 33 34
  • 92.25 (n)
cow
(Bos Taurus)
Mammalia TMF1 33 34
  • 91.91 (n)
mouse
(Mus musculus)
Mammalia Tmf1 33 16 34
  • 86 (n)
rat
(Rattus norvegicus)
Mammalia Tmf1 33
  • 85.35 (n)
oppossum
(Monodelphis domestica)
Mammalia TMF1 34
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMF1 34
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMF1 33 34
  • 75.6 (n)
lizard
(Anolis carolinensis)
Reptilia TMF1 34
  • 72 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii tmf1 33 34
  • 63.37 (n)
Dr.14269 33
fruit fly
(Drosophila melanogaster)
Insecta CG4557 34
  • 27 (a)
OneToOne
Species where no ortholog for TMF1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMF1 Gene

ENSEMBL:
Gene Tree for TMF1 (if available)
TreeFam:
Gene Tree for TMF1 (if available)

Paralogs for TMF1 Gene

Pseudogenes.org Pseudogenes for TMF1 Gene

genes like me logo Genes that share paralogs with TMF1: view

No data available for Paralogs for TMF1 Gene

Variants for TMF1 Gene

Sequence variations from dbSNP and Humsavar for TMF1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000072943 -- 69,051,602(+) GACGC(G/T)AAGCA intron-variant
rs1000073728 -- 69,046,871(+) ACTAA(C/T)AACAG intron-variant
rs1000091140 -- 69,029,091(+) TGGGG(G/T)GCAAT intron-variant
rs1000126432 -- 69,051,972(+) CTCGG(A/C)CCAGA reference, missense
rs1000298310 -- 69,039,120(+) GAGAC(A/C)AAGTC intron-variant

Variation tolerance for TMF1 Gene

Residual Variation Intolerance Score: 20.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.33; 70.67% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMF1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TMF1 Gene

Disorders for TMF1 Gene

Relevant External Links for TMF1

Genetic Association Database (GAD)
TMF1
Human Genome Epidemiology (HuGE) Navigator
TMF1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMF1

No disorders were found for TMF1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMF1 Gene

Publications for TMF1 Gene

  1. Isolation and characterization of ARA160 as the first androgen receptor N-terminal-associated coactivator in human prostate cells. (PMID: 10428808) Hsiao PW … Chang C (The Journal of biological chemistry 1999) 3 4 22 60
  2. Cloning and chromosomal mapping of a human immunodeficiency virus 1 "TATA" element modulatory factor. (PMID: 1409643) Garcia JA … Gaynor RB (Proceedings of the National Academy of Sciences of the United States of America 1992) 2 3 4 60
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  4. Functional involvement of TMF/ARA160 in Rab6-dependent retrograde membrane traffic. (PMID: 17698061) Yamane J … Tsukita S (Experimental cell research 2007) 3 4 60
  5. A putative nuclear receptor coactivator (TMF/ARA160) associates with hbrm/hSNF2 alpha and BRG-1/hSNF2 beta and localizes in the Golgi apparatus. (PMID: 12044884) Mori K … Kato H (FEBS letters 2002) 3 4 60

Products for TMF1 Gene

Sources for TMF1 Gene

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