TMF1 Gene
protein-coding GIFtS: 53
GCID: GC03M069068
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TATA element modulatory factor 1
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Aliases for TMF1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| TATA Element Modulatory Factor 11 2 | | ARA1601 2 3 | | TMF1 2 3 | | Androgen Receptor Coactivator 160 KDa Protein2 3 | | Androgen Receptor-Associated Protein Of 160 KDa2 3 | | TATA Element Modulatory Factor2 |
Export aliases for TMF1 gene to outside databasesPrevious GC identifers: GC03M067611 GC03M068445 GC03M068892 GC03M069005 GC03M069155 |
Summaries for TMF1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: TMF1_HUMAN, P82094Function: Potential coactivator of the androgen receptor. Mediates STAT3 degradation. May play critical roles in twoRAB6-dependent retrograde transport processes: one from endosomes to the Golgi and the other from the Golgi to the ER.This protein binds the HIV-1 TATA element and inhibits transcriptional activation by the TATA-binding protein (TBP) Gene Wiki entry for TMF1
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Genomic Views for TMF1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_022459.15
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the TMF1 gene promoter: SRF C/EBPbeta STAT1 AML1a SRF (504 AA) IRF-7A STAT3 RSRFC4 Other transcription factors
Search SABiosciences Chromatin IP Primers for TMF1
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMF1 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3p21-p12 Ensembl cytogenetic band: 3p14.1 HGNC cytogenetic band: 3p21-p12TMF1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03M069068: view genomic region
(about GC identifiers)
Start:
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69,068,978 bp from pter |
End:
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69,101,484 bp from pter |
Size:
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32,507 bases |
Orientation:
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minus strand |
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Proteins for TMF1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: TMF1_HUMAN, P82094 (See
protein sequence)Recommended Name: TATA element modulatory factor Size: 1093 amino acids; 122842 Da
Subunit: Componement of the SNF/SWI transcription factor complexes. Interacts with RAB6A. Interacts with STAT3 and FER.Interacts with TCEB1
Subcellular location: Cytoplasm. Nucleus. Golgi apparatus membrane. Note=Concentrated at the budding structureslocalized at the tips of cisternae
Sequence caution: Sequence=AAD54608.1; Type=Frameshift; Positions=969, 971, 975, 985; Sequence=BAD92346.1;Type=Erroneous initiation;
Secondary accessions: B7ZLJ2 Q17R87 Q59GK0Alternative splicing: 2 isoforms: P82094-1 P82094-2 Explore the universe of human proteins at neXtProt for TMF1: NX_P82094
Post-translational modifications:
Phosphorylated by FER (By similarity)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P82094 TMF1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_009045.2 ENSEMBL proteins: ENSP00000381567 ENSP00000419330 ENSP00000438706 Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
TMF1 for ontologies About GeneDecksing
TMF1 Antibody Products: Assay Products for TMF1: |
Protein
Domains / Families for TMF1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TMF1 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P82094ProtoNet protein and cluster: P82094 UniProtKB/Swiss-Prot: TMF1_HUMAN, P82094Domain: The Elongin BC complex binding domain is also known as BC-box with the consensus [APST]-L-x(3)-C-x(3)-[AILV] |
Function for TMF1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: TMF1_HUMAN, P82094Function: Potential coactivator of the androgen receptor. Mediates STAT3 degradation. May play critical roles in twoRAB6-dependent retrograde transport processes: one from endosomes to the Golgi and the other from the Golgi to the ER.This protein binds the HIV-1 TATA element and inhibits transcriptional activation by the TATA-binding protein (TBP)Induction: Down-regulated in malignant brain tumors Genatlas biochemistry entry for TMF1:TATA element modulatory factor (123kDa),with leucine zipper motif
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMF1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMF1 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TMF1 (NM_007114) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMF1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMF1  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMF1 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
TMF1 for ontologies About GeneDecksing
Animal Models: 2 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Tmf1):
TMF1 for phenotypes About GeneDecksing
|
Pathways & Interactions for TMF1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
| Unified GeneCards pathways  About this table  See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Coregulation of Androgen receptor activity | |
1 BioSystems Pathway for TMF1 
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TMF1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 9)
 5/15 Interacting proteins for TMF1 (P820941, 2, 3 ENSP000003815674) via UniProtKB, MINT, STRING, and/or I2D (see all 15)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- | | GO:0006366 | transcription from RNA polymerase II promoter |
TAS | 1409643 |
TMF1 for ontologies About GeneDecksing
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Drugs & Compounds for TMF1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
TMF1 for compounds About GeneDecksing
Browse Tocris compounds for TMF1 1 Novoseek chemical compound relationship for TMF1 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| testosterone |
26.6 |
3 |
10428808 (3) |
Search CenterWatch for drugs/clinical trials and news about TMF1 
|
Transcripts for TMF1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for TMF1 gene: NM_007114.2 Unigene Cluster for TMF1: TATA element modulatory factor 1 Hs.267632 [show with all ESTs]Unigene Representative Sequence: NM_0071145 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000398559 ENST00000488010 ENST00000489370 ENST00000477872 ENST00000543976(uc003dnn.3 uc011bfx.2)
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMF1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMF1 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TMF1 (NM_007114) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMF1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMF1  |
Additional cDNA sequence: AB209109.1 AK096365.1 AK299020.1 AK312697.1 BC008454.1 BC033771.2 BC117418.1 BC126123.1 BC143840.1 L01042.1 7 DOTS entries: DT.113913 DT.120899470 DT.92417666 DT.40248459 DT.97774570 DT.120899466 DT.91742381 24/226 AceView cDNA sequences (see all 226): W93368 AA328247 AL704700 CD623683 AI129878 CD623682 AI767750 CD724271 AA287583 AA804882 CA503339 BU429475 AW236504 AU118992 CB306724 BC033771 CN484347 BX505006 BQ016294 CD623686 BX955939 AL705193 BQ940432 AL040699 GeneLoc Exon Structure
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Expression for TMF1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TMF1 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: GATCTGATTG
About this image See TMF1 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for TMF1
SOURCE GeneReport for Unigene cluster: Hs.267632 SABiosciences Custom PCR Arrays for TMF1
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMF1 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TMF1 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMF1 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMF1 | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMF1 |
Orthologs for TMF1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for TMF1 gene from 9/27 species (see all 27) About this table
ENSEMBL Gene Tree for TMF1 (if available) TreeFam Gene Tree for TMF1 (if available)  |
Paralogs for TMF1 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for TMF1 gene
TMF1 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for TMF1 PGOHUM00000248987
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Genomic Variants for TMF1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 3 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for TMF1 (69068978 - 69101484 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for TMF1: --  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMF1 |
|
Disorders
/ Diseases for TMF1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TMF1 for disorders About GeneDecksing
OMIM gene information: 601126
OMIM disorders: --
5 diseases for TMF1: About MalaCardsmycosis fungoides prostate cancer prostatitis ataxia immunodeficiency 1 disease from the University of Copenhagen DISEASES database for TMF1:Kennedy's disease 1 Novoseek disease relationship for TMF1 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| prostate cancer |
24 |
1 |
10428808 (1) |
Human Genome Epidemiology (HuGE) Navigator: TMF1 (1 document) Export disorders for TMF1 gene to outside databases
|
Publications for TMF1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TMF1 gene, integrated from 9 sources (see all 35): (articles sorted by number of sources associating them with TMF1) | |  | Utopia: connect your pdf to the dynamic world of online information |
- Cloning and chromosomal mapping of a human immunodeficiency virus 1 'TATA' element modulatory factor. (PubMed id 1409643)1, 2, 3 Garcia J.A.... Gaynor R.B. (1992)
- Isolation and characterization of ARA160 as the first androgen receptor N-terminal-associated coactivator in human prostate cells. (PubMed id 10428808)1, 2, 9 Hsiao P.W. and Chang C. (1999)
- Functional involvement of TMF/ARA160 in Rab6-dependent retrograde membrane traffic. (PubMed id 17698061)1, 2 Yamane J....Tsukita S. (2007)
- A putative nuclear receptor coactivator (TMF/ARA160) associates with hbrm/hSNF2 alpha and BRG-1/hSNF2 beta and localizes in the Golgi apparatus. (PubMed id 12044884)1, 2 Mori K. and Kato H. (2002)
- Intersectin (ITSN) family of scaffolds function as mol ecular hubs in protein interaction networks. (PubMed id 22558309)1 Wong K.A....O'Bryan J.P. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
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External Searches for TMF1 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
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Genome Databases showing TMF1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TMF1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TMF1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
|
About This Section
| Patent Information for TMF1 gene: Search GeneIP for patents involving TMF1
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for TMF1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
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 | |
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| | | | Browse OriGene Antibodies | | OriGene shRNA RFP for TMF1 | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMF1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMF1 | | OriGene Protein Over-expression Lysate for TMF1 | | Browse OriGene Fluorogenic Cell Assay Kits | | OriGene siRNA for TMF1 | | OriGene 3'-UTR Clone for TMF1 | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMF1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMF1 | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | OriGene Custom Antibody Services for TMF1 | | OriGene Custom Protein Services for TMF1 | | OriGene Custom Immunoassay Development | | |
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| | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TMF1 | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMF1 | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMF1 | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMF1 | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMF1 | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMF1 |
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| | | Search Tocris compounds for TMF1 |
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 | | TMF1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMF1 |
|  |  |  | | | Search ThermoFisher Antibodies for TMF1 |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMF1 |
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