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TMF1 Gene

protein-coding   GIFtS: 56
GCID: GC03M069068

TATA Element Modulatory Factor 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
TATA Element Modulatory Factor 11 2
Androgen Receptor Coactivator 160 KDa Protein2 3
Androgen Receptor-Associated Protein Of 160 KDa2 3
ARA1602 3
TMF2 3
TATA Element Modulatory Factor2

External Ids:    HGNC: 118701   Entrez Gene: 71102   Ensembl: ENSG000001447477   OMIM: 6011265   UniProtKB: P820943   

Export aliases for TMF1 gene to outside databases

Previous GC identifers: GC03M067611 GC03M068445 GC03M068892 GC03M069005 GC03M069155


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TMF1 Gene:
TMF1 (TATA element modulatory factor 1) is a protein-coding gene. Diseases associated with TMF1 include kennedy's disease, and mycosis fungoides. GO annotations related to this gene include transcription cofactor activity.

UniProtKB/Swiss-Prot: TMF1_HUMAN, P82094
Function: Potential coactivator of the androgen receptor. Mediates STAT3 degradation. May play critical roles in
two RAB6-dependent retrograde transport processes: one from endosomes to the Golgi and the other from the Golgi
to the ER. This protein binds the HIV-1 TATA element and inhibits transcriptional activation by the TATA-binding
protein (TBP)

Gene Wiki entry for TMF1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NC_018914.2  NT_022517.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the TMF1 gene promoter:
         SRF   C/EBPbeta   STAT1   AML1a   SRF (504 AA)   IRF-7A   STAT3   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMF1 promoter sequence
   Search Chromatin IP Primers for TMF1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TMF1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21-p12   Ensembl cytogenetic band:  3p14.1   HGNC cytogenetic band: 3p21-p12

TMF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMF1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M069068:  view genomic region     (about GC identifiers)

Start:
69,068,978 bp from pter      End:
69,101,484 bp from pter
Size:
32,507 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TMF1_HUMAN, P82094 (See protein sequence)
Recommended Name: TATA element modulatory factor  
Size: 1093 amino acids; 122842 Da
Subunit: Interacts with TRNP1; may regulate TRNP1 proteasomal degradation (By similarity). Component of the
SNF/SWI transcription factor complexes. Interacts with RAB6A. Interacts with STAT3 and FER. Interacts with TCEB1
Sequence caution: Sequence=AAD54608.1; Type=Frameshift; Positions=969, 971, 975, 985; Sequence=BAD92346.1;
Type=Erroneous initiation;
Secondary accessions: B7ZLJ2 Q17R87 Q59GK0
Alternative splicing: 2 isoforms:  P82094-1   P82094-2   

Explore the universe of human proteins at neXtProt for TMF1: NX_P82094

Explore proteomics data for TMF1 at MOPED

Post-translational modifications: 

  • Phosphorylated by FER (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TMF1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_009045.2  
    ENSEMBL proteins: 
     ENSP00000381567   ENSP00000419330   ENSP00000438706  

    TMF1 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for TMF1
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    Novus Biologicals TMF1 Lysate
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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for TMF1

    TMF1 Antibody Products:

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    LSBio Antibodies in human, mouse, rat for TMF1

    TMF1 Assay Products:

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    Cloud-Clone Corp. ELISAs for TMF1
    Cloud-Clone Corp. CLIAs for TMF1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR022092 TMF_DNA-bd
     IPR022091 TMF_TATA-bd

    Graphical View of Domain Structure for InterPro Entry P82094

    ProtoNet protein and cluster: P82094

    UniProtKB/Swiss-Prot: TMF1_HUMAN, P82094
    Domain: The Elongin BC complex binding domain is also known as BC-box with the consensus
    [APST]-L-x(3)-C-x(3)-[AILV]


    TMF1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TMF1_HUMAN, P82094
    Function: Potential coactivator of the androgen receptor. Mediates STAT3 degradation. May play critical roles in
    two RAB6-dependent retrograde transport processes: one from endosomes to the Golgi and the other from the Golgi
    to the ER. This protein binds the HIV-1 TATA element and inhibits transcriptional activation by the TATA-binding
    protein (TBP)
    Induction: Down-regulated in malignant brain tumors

         Genatlas biochemistry entry for TMF1:
    TATA element modulatory factor (123kDa),with leucine zipper motif

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003712transcription cofactor activity TAS10428808
    GO:0005515protein binding IPI--
         
    TMF1 for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Tmf1):
     endocrine/exocrine gland  reproductive system 

    TMF1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TMF1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TMF1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TMF1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TMF1

    miRNA
    Products:
        
    miRTarBase miRNAs that target TMF1:
    hsa-mir-92a-3p (MIRT048920), hsa-mir-1914-5p (MIRT035780), hsa-mir-4324 (MIRT052835), hsa-mir-362-5p (MIRT044050), hsa-mir-484 (MIRT041639), hsa-mir-32-5p (MIRT028279), hsa-mir-331-3p (MIRT043258), hsa-mir-424-5p (MIRT042436)

    Block miRNA regulation of human, mouse, rat TMF1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TMF1 (see all 69):
    hsa-miR-548j hsa-miR-607 hsa-miR-4272 hsa-miR-3613-3p hsa-miR-548a-5p hsa-miR-92b hsa-miR-1231 hsa-miR-559
    SwitchGear 3'UTR luciferase reporter plasmidTMF1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for TMF1
    Predesigned siRNA for gene silencing in human, mouse, rat TMF1

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: TMF1 (NM_007114)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMF1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMF1

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for TMF1 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMF1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TMF1_HUMAN, P82094: Cytoplasm. Nucleus. Golgi apparatus membrane. Note=Concentrated at the budding structures
    localized at the tips of cisternae
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    nucleus5
    cytosol1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0005634nucleus IEA--
    GO:0005783endoplasmic reticulum IEA--
    GO:0005794Golgi apparatus IDA--

    TMF1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TMF1 About    
    See pathways by source

    SuperPathContained pathways About
    1Coregulation of Androgen receptor activity
    Coregulation of Androgen receptor activity


    1 BioSystems Pathway for TMF1
        Coregulation of Androgen receptor activity


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TMF1
    Interactions:

        GeneGlobe Interaction Network for TMF1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TMF1 (P820941, 2, 3 ENSP000003815674) via UniProtKB, MINT, STRING, and/or I2D (see all 43)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GFI1BQ5VTD92, 3, ENSP000003447824MINT-2863645 I2D: score=3 STRING: ENSP00000344782
    NR3C1P041501, 3EBI-949763,EBI-493507 I2D: score=1 
    ARP102753, ENSP000003638224I2D: score=2 STRING: ENSP00000363822
    SMARCA4P515323, ENSP000003507204I2D: score=1 STRING: ENSP00000350720
    FERP165913, ENSP000002810924I2D: score=2 STRING: ENSP00000281092
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001675acrosome assembly IEA--
    GO:0001819positive regulation of cytokine production IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0006366transcription from RNA polymerase II promoter TAS1409643
    GO:0007286spermatid development ----

    TMF1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TMF1

    1 Novoseek inferred chemical compound relationship for TMF1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    testosterone 26.6 3 10428808 (3)



    TMF1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TMF1 gene: 
    NM_007114.2  

    Unigene Cluster for TMF1:

    TATA element modulatory factor 1
    Hs.267632  [show with all ESTs]
    Unigene Representative Sequence: NM_007114
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000398559 ENST00000488010 ENST00000489370 ENST00000477872 ENST00000543976(uc003dnn.3 uc011bfx.2)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TMF1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TMF1 (see all 69):
    hsa-miR-548j hsa-miR-607 hsa-miR-4272 hsa-miR-3613-3p hsa-miR-548a-5p hsa-miR-92b hsa-miR-1231 hsa-miR-559
    SwitchGear 3'UTR luciferase reporter plasmidTMF1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TMF1
    Predesigned siRNA for gene silencing in human, mouse, rat TMF1
    Clone
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    OriGene clones in human, mouse for TMF1 (see all 7)
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TMF1 (NM_007114)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMF1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMF1
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for TMF1
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      QuantiTect SYBR Green Assays in human, mouse, rat TMF1
      QuantiFast Probe-based Assays in human, mouse, rat TMF1

    Additional mRNA sequence: 

    AB209109.1 AK096365.1 AK299020.1 AK312697.1 BC008454.1 BC033771.2 BC117418.1 BC126123.1 
    BC143840.1 L01042.1 

    7 DOTS entries:

    DT.113913  DT.120899470  DT.92417666  DT.40248459  DT.97774570  DT.120899466  DT.91742381 

    Selected AceView cDNA sequences (see all 226):

    CB306724 AI129878 BP374566 AA745498 AL700087 N68210 AI651312 AA804882 
    BF057855 CD623682 BP360680 CD623692 AI362862 CD623683 AW137268 AI638097 
    CD623694 AA287536 BQ016294 AA252318 BX505006 BX955939 BU429475 R79599 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TMF1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATCTGATTG
    TMF1 Expression
    About this image

    TMF1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TMF1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.267632
        Custom PCR Arrays for TMF1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMF1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TMF1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tmf11 , 5 TATA element modulatory factor 11, 5 86(n)1
    87.68(a)1
      6 (44.89 cM)5
    2322861  NM_001081111.21  NP_001074580.11 
     971552665 
    chicken
    (Gallus gallus)
    Aves TMF11 TATA element modulatory factor 1 75.6(n)
    77.58(a)
      426072  XM_423749.4  XP_423749.2 
    lizard
    (Anolis carolinensis)
    Reptilia TMF16
    TATA element modulatory factor 1
    72(a)
    1 ↔ 1
    2(182362076-182390404)
    African clawed frog
    (Xenopus laevis)
    Amphibia 480369132   -- 73.31(n)    48036913 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.142692 Transcribed sequence with weak similarity to protein more 77.57(n)    57049750 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG45576
    --
    27(a)
    1 ↔ 1
    X(6738376-6741880)


    ENSEMBL Gene Tree for TMF1 (if available)
    TreeFam Gene Tree for TMF1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TMF1 gene

    TMF1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for TMF1
    PGOHUM00000248987


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TMF1 (see all 675)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1432222761,2
    --69068483(+) TTAGCA/CCTGTG 1 -- int10--------
    rs1483834971,2
    --69068542(+) CGCAGC/TGGCTT 1 -- int10--------
    rs1415664301,2
    --69068673(+) TGGTGC/TGCACC 1 -- int10--------
    rs1881412331,2
    --69068790(+) AGAGTA/GAGACT 1 -- int10--------
    rs1910966951,2
    --69068988(+) ATTTTA/GAAATC 1 -- ut310--------
    rs1143276211,2
    C,F--69069300(+) TTCAAA/GTAAAA 1 -- ut311Minor allele frequency- G:0.03WA 118
    rs1508881771,2
    C--69069484(+) TGGCAA/GTTCTC 1 -- ut310--------
    rs1836412801,2
    --69069502(+) AGGTAA/GAAGAA 1 -- ut310--------
    rs763520611,2
    C,F--69069597(+) AACAAC/ACTTCC 1 -- ut311Minor allele frequency- A:0.02WA 118
    rs1891811481,2
    --69069700(+) ATCCAC/TTAAAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for TMF1 (69068978 - 69101484 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for TMF1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv876933CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TMF1
    DNA2.0 Custom Variant and Variant Library Synthesis for TMF1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601126    OMIM disorders: --

    7 diseases for TMF1:    
    About MalaCards
    kennedy's disease    mycosis fungoides    prostate cancer    prostatitis
    ataxia    hiv-1    malaria

    1 disease from the University of Copenhagen DISEASES database for TMF1:
    Kennedy's disease

    TMF1 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for TMF1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    prostate cancer 24 1 10428808 (1)

    Genetic Association Database (GAD): TMF1
    Human Genome Epidemiology (HuGE) Navigator: TMF1 (1 document)

    Export disorders for TMF1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TMF1 gene, integrated from 10 sources (see all 39):
    (articles sorted by number of sources associating them with TMF1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and chromosomal mapping of a human immunodeficiency virus 1 'TATA' element modulatory factor. (PubMed id 1409643)1, 2, 3 Garcia J.A.... Gaynor R.B. (Proc. Natl. Acad. Sci. U.S.A. 1992)
    2. Isolation and characterization of ARA160 as the first androgen receptor N-terminal-associated coactivator in human prostate cells. (PubMed id 10428808)1, 2, 9 Hsiao P.W. and Chang C. (J. Biol. Chem. 1999)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Functional involvement of TMF/ARA160 in Rab6-dependent retrograde membrane traffic. (PubMed id 17698061)1, 2 Yamane J....Tsukita S. (Exp. Cell Res. 2007)
    5. A putative nuclear receptor coactivator (TMF/ARA160) associates with hbrm/hSNF2 alpha and BRG-1/hSNF2 beta and localizes in the Golgi apparatus. (PubMed id 12044884)1, 2 Mori K. and Kato H. (FEBS Lett. 2002)
    6. Molecular insights into vesicle tethering at the Golgi by the conserved oligomeric Golgi (COG) complex and the golgin TATA element modulatory factor (TMF). (PubMed id 23239882)1 Miller V.J....Ungar D. (J. Biol. Chem. 2013)
    7. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    8. Intersectin (ITSN) family of scaffolds function as molecular hubs in protein interaction networks. (PubMed id 22558309)1 Wong K.A....O'Bryan J.P. (PLoS ONE 2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    10. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7110 HGNC: 11870 AceView: TMF1 Ensembl:ENSG00000144747 euGenes: HUgn7110
    ECgene: TMF1 H-InvDB: TMF1

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TMF1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TMF1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TMF1 gene:
    Search GeneIP for patents involving TMF1

    GeneCards and IP:
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