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Aliases for TMF1 Gene

Aliases for TMF1 Gene

  • TATA Element Modulatory Factor 1 2 3 5
  • Androgen Receptor-Associated Protein Of 160 KDa 3 4
  • Androgen Receptor Coactivator 160 KDa Protein 3 4
  • ARA160 3 4
  • TMF 3 4

External Ids for TMF1 Gene

Previous GeneCards Identifiers for TMF1 Gene

  • GC03M067611
  • GC03M068445
  • GC03M068892
  • GC03M069005
  • GC03M069155
  • GC03M069068

Summaries for TMF1 Gene

GeneCards Summary for TMF1 Gene

TMF1 (TATA Element Modulatory Factor 1) is a Protein Coding gene. Among its related pathways are Vesicle-mediated transport and Golgi-to-ER retrograde transport. GO annotations related to this gene include transcription cofactor activity.

UniProtKB/Swiss-Prot for TMF1 Gene

  • Potential coactivator of the androgen receptor. Mediates STAT3 degradation. May play critical roles in two RAB6-dependent retrograde transport processes: one from endosomes to the Golgi and the other from the Golgi to the ER. This protein binds the HIV-1 TATA element and inhibits transcriptional activation by the TATA-binding protein (TBP).

Gene Wiki entry for TMF1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMF1 Gene

Genomics for TMF1 Gene

Regulatory Elements for TMF1 Gene

Promoters for TMF1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TMF1 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMF1 Gene

Chromosome:
3
Start:
69,019,827 bp from pter
End:
69,052,333 bp from pter
Size:
32,507 bases
Orientation:
Minus strand

Genomic View for TMF1 Gene

Genes around TMF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMF1 Gene

Proteins for TMF1 Gene

  • Protein details for TMF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P82094-TMF1_HUMAN
    Recommended name:
    TATA element modulatory factor
    Protein Accession:
    P82094
    Secondary Accessions:
    • B7ZLJ2
    • Q17R87
    • Q59GK0

    Protein attributes for TMF1 Gene

    Size:
    1093 amino acids
    Molecular mass:
    122842 Da
    Quaternary structure:
    • Interacts with TRNP1; may regulate TRNP1 proteasomal degradation (By similarity). Component of the SNF/SWI transcription factor complexes. Interacts with RAB6A. Interacts with STAT3 and FER. Interacts with TCEB1.
    SequenceCaution:
    • Sequence=AAD54608.1; Type=Frameshift; Positions=969, 971, 975, 985; Evidence={ECO:0000305}; Sequence=BAD92346.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TMF1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMF1 Gene

Proteomics data for TMF1 Gene at MOPED

Post-translational modifications for TMF1 Gene

Other Protein References for TMF1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for TMF1 Gene

Domains & Families for TMF1 Gene

Protein Domains for TMF1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMF1 Gene

Graphical View of Domain Structure for InterPro Entry

P82094

UniProtKB/Swiss-Prot:

TMF1_HUMAN :
  • The Elongin BC complex binding domain is also known as BC-box with the consensus [APST]-L-x(3)-C-x(3)-[AILV].
Domain:
  • The Elongin BC complex binding domain is also known as BC-box with the consensus [APST]-L-x(3)-C-x(3)-[AILV].
genes like me logo Genes that share domains with TMF1: view

No data available for Gene Families for TMF1 Gene

Function for TMF1 Gene

Molecular function for TMF1 Gene

GENATLAS Biochemistry:
TATA element modulatory factor (123kDa),with leucine zipper motif
UniProtKB/Swiss-Prot Function:
Potential coactivator of the androgen receptor. Mediates STAT3 degradation. May play critical roles in two RAB6-dependent retrograde transport processes: one from endosomes to the Golgi and the other from the Golgi to the ER. This protein binds the HIV-1 TATA element and inhibits transcriptional activation by the TATA-binding protein (TBP).
UniProtKB/Swiss-Prot Induction:
Down-regulated in malignant brain tumors.
genes like me logo Genes that share phenotypes with TMF1: view

Animal Models for TMF1 Gene

MGI Knock Outs for TMF1:

Animal Model Products

  • Taconic Biosciences Mouse Models for TMF1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TMF1 Gene

Localization for TMF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMF1 Gene

Cytoplasm. Nucleus. Golgi apparatus membrane. Note=Concentrated at the budding structures localized at the tips of cisternae.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMF1 Gene COMPARTMENTS Subcellular localization image for TMF1 gene
Compartment Confidence
golgi apparatus 5
nucleus 5
endoplasmic reticulum 2
cytosol 1

Gene Ontology (GO) - Cellular Components for TMF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
genes like me logo Genes that share ontologies with TMF1: view

Pathways & Interactions for TMF1 Gene

genes like me logo Genes that share pathways with TMF1: view

Gene Ontology (GO) - Biological Process for TMF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001819 positive regulation of cytokine production IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007286 spermatid development IEA --
GO:0007289 spermatid nucleus differentiation IEA --
GO:0008584 male gonad development IEA --
genes like me logo Genes that share ontologies with TMF1: view

No data available for SIGNOR curated interactions for TMF1 Gene

Drugs & Compounds for TMF1 Gene

(1) Drugs for TMF1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with TMF1: view

Transcripts for TMF1 Gene

Unigene Clusters for TMF1 Gene

TATA element modulatory factor 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMF1 Gene

No ASD Table

Relevant External Links for TMF1 Gene

GeneLoc Exon Structure for
TMF1
ECgene alternative splicing isoforms for
TMF1

Expression for TMF1 Gene

mRNA expression in normal human tissues for TMF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TMF1 Gene

This gene is overexpressed in Brain (11.9), Pancreas (11.8), Adrenal (8.0), and Frontal cortex (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TMF1 Gene



SOURCE GeneReport for Unigene cluster for TMF1 Gene Hs.267632

genes like me logo Genes that share expression patterns with TMF1: view

Protein tissue co-expression partners for TMF1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TMF1 Gene

Orthologs for TMF1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMF1 35
  • 99.51 (n)
  • 99.45 (a)
TMF1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMF1 36
  • 92 (a)
OneToOne
TMF1 35
  • 91.91 (n)
  • 92.67 (a)
dog
(Canis familiaris)
Mammalia TMF1 35
  • 92.25 (n)
  • 93.57 (a)
TMF1 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmf1 16
Tmf1 36
  • 87 (a)
OneToOne
Tmf1 35
  • 86 (n)
  • 87.68 (a)
oppossum
(Monodelphis domestica)
Mammalia TMF1 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMF1 36
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmf1 35
  • 85.35 (n)
  • 86.97 (a)
chicken
(Gallus gallus)
Aves TMF1 35
  • 75.6 (n)
  • 77.58 (a)
TMF1 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMF1 36
  • 72 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii tmf1 36
  • 58 (a)
OneToOne
Dr.14269 35
tmf1 35
  • 63.37 (n)
  • 63.56 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4557 36
  • 27 (a)
OneToOne
Species with no ortholog for TMF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMF1 Gene

ENSEMBL:
Gene Tree for TMF1 (if available)
TreeFam:
Gene Tree for TMF1 (if available)

Paralogs for TMF1 Gene

Pseudogenes.org Pseudogenes for TMF1 Gene

genes like me logo Genes that share paralogs with TMF1: view

No data available for Paralogs for TMF1 Gene

Variants for TMF1 Gene

Sequence variations from dbSNP and Humsavar for TMF1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1532918 - 69,033,557(-) TTTCT(A/C/G)ATAGG reference, missense
rs35447207 - 69,047,417(+) ACACT(C/G)CTCAG reference, missense
rs34428015 - 69,047,362(+) CCTTG(C/T)AAACA reference, missense
rs3736422 - 69,038,670(+) CTTCC(C/T)GTGCC reference, missense
rs1745 -- 69,021,306(+) GTCTT(A/G)GAACG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TMF1 Gene

Variant ID Type Subtype PubMed ID
nsv876933 CNV Loss 21882294

Variation tolerance for TMF1 Gene

Residual Variation Intolerance Score: 20.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.33; 70.67% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMF1 Gene

HapMap Linkage Disequilibrium report
TMF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMF1 Gene

Disorders for TMF1 Gene

Relevant External Links for TMF1

Genetic Association Database (GAD)
TMF1
Human Genome Epidemiology (HuGE) Navigator
TMF1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMF1

No disorders were found for TMF1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMF1 Gene

Publications for TMF1 Gene

  1. Cloning and chromosomal mapping of a human immunodeficiency virus 1 'TATA' element modulatory factor. (PMID: 1409643) Garcia J.A. … Gaynor R.B. (Proc. Natl. Acad. Sci. U.S.A. 1992) 2 3 4 67
  2. Isolation and characterization of ARA160 as the first androgen receptor N-terminal-associated coactivator in human prostate cells. (PMID: 10428808) Hsiao P.W. … Chang C. (J. Biol. Chem. 1999) 3 23
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Primary immunodeficiency caused by an exonized retroposed gene copy inserted in the CYBB gene. (PMID: 24478191) de Boer M. … Roos D. (Hum. Mutat. 2014) 3
  5. Molecular insights into vesicle tethering at the Golgi by the conserved oligomeric Golgi (COG) complex and the golgin TATA element modulatory factor (TMF). (PMID: 23239882) Miller V.J. … Ungar D. (J. Biol. Chem. 2013) 3

Products for TMF1 Gene

Sources for TMF1 Gene

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