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Aliases for TMEM9B Gene

Aliases for TMEM9B Gene

  • TMEM9 Domain Family Member B 2 3 5
  • C11orf15 3 4
  • Chromosome 11 Open Reading Frame 15 2
  • TMEM9 Domain Family, Member B 2
  • Transmembrane Protein 9B 3

External Ids for TMEM9B Gene

Previous HGNC Symbols for TMEM9B Gene

  • C11orf15

Previous GeneCards Identifiers for TMEM9B Gene

  • GC11M008926
  • GC11M008927
  • GC11M008639

Summaries for TMEM9B Gene

GeneCards Summary for TMEM9B Gene

TMEM9B (TMEM9 Domain Family Member B) is a Protein Coding gene. GO annotations related to this gene include signal transducer activity. An important paralog of this gene is TMEM9.

UniProtKB/Swiss-Prot for TMEM9B Gene

  • Enhances production of proinflammatory cytokines induced by TNF, IL1B, and TLR ligands. Has a role in TNF activation of both the NF-kappaB and MAPK pathways.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM9B Gene

Genomics for TMEM9B Gene

Regulatory Elements for TMEM9B Gene

Enhancers for TMEM9B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G008962 1.1 ENCODE 15.6 +0.6 649 3.9 PKNOX1 FOXA2 AGO1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 TMEM9B-AS1 TMEM9B AKIP1 ENSG00000238387 ENSG00000223080
GH11G009039 1.4 FANTOM5 Ensembl ENCODE 10.2 -74.2 -74243 0.5 PKNOX1 BMI1 RAD21 ZNF207 ETV6 FOS RELB CREM IKZF2 CBFB TMEM9B-AS1 TMEM9B NRIP3 ZNF143 DENND5A RPL27A LOC105376541 MIR5691
GH11G008829 1.3 Ensembl ENCODE dbSUPER 10.6 +132.2 132199 7.2 YBX3 HDGF PKNOX1 ZSCAN4 YBX1 TCF12 GATA2 ZNF143 EGR2 SMARCA5 TMEM9B-AS1 AKIP1 SCUBE2 WEE1 TMEM9B EIF3F RPL27A ENSG00000254665 ENSG00000254900 RNA5SP330
GH11G008772 1.7 FANTOM5 Ensembl ENCODE dbSUPER 7 +188.8 188803 7.7 FOXA2 MLX ARID4B DMAP1 ZNF48 YY1 TCF12 SLC30A9 MXD4 MIER2 AKIP1 SCUBE2 TMEM9B TMEM9B-AS1 ASCL3 LOC102724784 ENSG00000255159 GC11P008791
GH11G009003 0.9 ENCODE 13.1 -39.0 -39028 1.1 HDGF TBP ATF1 RB1 CREB3L1 FUS ZBTB40 KLF13 CREM KDM4B SNORA3B SCUBE2 TMEM9B RPL27A RPL21P97 AKIP1 NRIP3 GC11P008977
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM9B on UCSC Golden Path with GeneCards custom track

Promoters for TMEM9B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000036538 511 1801 PKNOX1 FOXA2 AGO1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766

Genomic Location for TMEM9B Gene

Chromosome:
11
Start:
8,947,201 bp from pter
End:
8,965,011 bp from pter
Size:
17,811 bases
Orientation:
Minus strand

Genomic View for TMEM9B Gene

Genes around TMEM9B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM9B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM9B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM9B Gene

Proteins for TMEM9B Gene

  • Protein details for TMEM9B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NQ34-TMM9B_HUMAN
    Recommended name:
    Transmembrane protein 9B
    Protein Accession:
    Q9NQ34
    Secondary Accessions:
    • Q7Z649

    Protein attributes for TMEM9B Gene

    Size:
    198 amino acids
    Molecular mass:
    22531 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM9B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM9B Gene

Post-translational modifications for TMEM9B Gene

Other Protein References for TMEM9B Gene

No data available for DME Specific Peptides for TMEM9B Gene

Domains & Families for TMEM9B Gene

Protein Domains for TMEM9B Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM9B Gene

Graphical View of Domain Structure for InterPro Entry

Q9NQ34

UniProtKB/Swiss-Prot:

TMM9B_HUMAN :
  • Belongs to the TMEM9 family.
Family:
  • Belongs to the TMEM9 family.
genes like me logo Genes that share domains with TMEM9B: view

No data available for Gene Families for TMEM9B Gene

Function for TMEM9B Gene

Molecular function for TMEM9B Gene

UniProtKB/Swiss-Prot Function:
Enhances production of proinflammatory cytokines induced by TNF, IL1B, and TLR ligands. Has a role in TNF activation of both the NF-kappaB and MAPK pathways.

Gene Ontology (GO) - Molecular Function for TMEM9B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IMP 12761501
genes like me logo Genes that share ontologies with TMEM9B: view
genes like me logo Genes that share phenotypes with TMEM9B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM9B Gene

Localization for TMEM9B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM9B Gene

Lysosome membrane; Single-pass membrane protein. Early endosome membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM9B gene
Compartment Confidence
lysosome 4
endosome 3
plasma membrane 2
extracellular 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for TMEM9B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005764 lysosome IEA --
GO:0005765 lysosomal membrane IEA --
GO:0005768 endosome IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM9B: view

Pathways & Interactions for TMEM9B Gene

SuperPathways for TMEM9B Gene

No Data Available

Interacting Proteins for TMEM9B Gene

Gene Ontology (GO) - Biological Process for TMEM9B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IMP 12761501
genes like me logo Genes that share ontologies with TMEM9B: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM9B Gene

Drugs & Compounds for TMEM9B Gene

No Compound Related Data Available

Transcripts for TMEM9B Gene

Unigene Clusters for TMEM9B Gene

TMEM9 domain family, member B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM9B Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c
SP1: - - - - - -
SP2: - - -
SP3:
SP4: - - - -
SP5: - - -

Relevant External Links for TMEM9B Gene

GeneLoc Exon Structure for
TMEM9B
ECgene alternative splicing isoforms for
TMEM9B

Expression for TMEM9B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM9B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TMEM9B Gene

This gene is overexpressed in Peripheral blood mononuclear cells (14.2), Pancreas (13.9), Breast (12.1), Heart (6.9), and Retina (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TMEM9B Gene



NURSA nuclear receptor signaling pathways regulating expression of TMEM9B Gene:

TMEM9B

SOURCE GeneReport for Unigene cluster for TMEM9B Gene:

Hs.501853

Evidence on tissue expression from TISSUES for TMEM9B Gene

  • Pancreas(4.2)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with TMEM9B: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM9B Gene

Orthologs for TMEM9B Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM9B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM9B 35 34
  • 99.83 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM9B 35 34
  • 93.43 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM9B 34 35
  • 91.75 (n)
rat
(Rattus norvegicus)
Mammalia Tmem9b 34
  • 90.86 (n)
mouse
(Mus musculus)
Mammalia Tmem9b 16 35 34
  • 90.76 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM9B 35
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM9B 35
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM9B 34 35
  • 82.22 (n)
lizard
(Anolis carolinensis)
Reptilia TMEM9B 35
  • 78 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii tmem9b 35 34
  • 76.16 (n)
OneToOne
wufd47d02 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5088 34
worm
(Caenorhabditis elegans)
Secernentea R12C12.6 35
  • 22 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 34 (a)
OneToMany
Species where no ortholog for TMEM9B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TMEM9B Gene

ENSEMBL:
Gene Tree for TMEM9B (if available)
TreeFam:
Gene Tree for TMEM9B (if available)

Paralogs for TMEM9B Gene

Paralogs for TMEM9B Gene

(1) SIMAP similar genes for TMEM9B Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with TMEM9B: view

Variants for TMEM9B Gene

Sequence variations from dbSNP and Humsavar for TMEM9B Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000045416 -- 8,965,599(+) CGCCG(C/T)CCGGC intron-variant, upstream-variant-2KB
rs1000232781 -- 8,966,880(+) TTCTA(C/T)GTTTG intron-variant, upstream-variant-2KB
rs1000263921 -- 8,966,573(+) CTGTT(C/G)TGGAA nc-transcript-variant, upstream-variant-2KB
rs1000551150 -- 8,963,083(+) GTTTC(C/T)GCCCA intron-variant, upstream-variant-2KB
rs1000772062 -- 8,962,816(+) CAAAA(C/G)AAGTT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TMEM9B Gene

Variant ID Type Subtype PubMed ID
esv2759803 CNV gain 17122850
esv3891928 CNV gain 25118596
nsv1119857 CNV deletion 24896259
nsv435923 CNV deletion 17901297
nsv499766 OTHER inversion 21111241
nsv7215 OTHER inversion 18451855
nsv832062 CNV loss 17160897

Variation tolerance for TMEM9B Gene

Residual Variation Intolerance Score: 40.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.41; 8.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM9B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM9B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM9B Gene

Disorders for TMEM9B Gene

Relevant External Links for TMEM9B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM9B

No disorders were found for TMEM9B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM9B Gene

Publications for TMEM9B Gene

  1. Comparative genomic sequencing reveals a strikingly similar architecture of a conserved syntenic region on human chromosome 11p15.3 (including gene ST5) and mouse chromosome 7. (PMID: 11528127) Amid C. … Schmidt E.R. (Cytogenet. Cell Genet. 2001) 2 3 4 64
  2. The lysosomal transmembrane protein 9B regulates the activity of inflammatory signaling pathways. (PMID: 18541524) Dodeller F. … Cenni B. (J. Biol. Chem. 2008) 4 22 64
  3. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z. … Henzel W.J. (Protein Sci. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64

Products for TMEM9B Gene

Sources for TMEM9B Gene

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