TMEM9B Gene
protein-coding GIFtS: 49
GCID: GC11M008969
|
|
TMEM9 domain family, member B(Previous name: chromosome 11 open reading frame 15 )
(Previous symbol: C11orf15)
| |
Aliases
for TMEM9B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| TMEM9 Domain Family, Member B1 2 | | C11orf151 2 3 | | Chromosome 11 Open Reading Frame 151 | | Transmembrane Protein 9B2 |
Export aliases for TMEM9B gene to outside databasesPrevious GC identifers: GC11M008926 GC11M008927 GC11M008639 |
Summaries
for TMEM9B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for TMEM9B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_009237.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TMEM9B gene promoter:
Nkx3-1 Nkx3-1 v4 Elk-1 HSF1 (long) Nkx3-1 v1 AREB6 Nkx3-1 v2 HSF1short Sox9 Nkx3-1 v3
Other transcription factors
Search SABiosciences Chromatin IP Primers for TMEM9B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM9B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11p15.3 Ensembl cytogenetic band: 11p15.4 HGNC cytogenetic band: 11p15.3TMEM9B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11M008969: view genomic region
(about GC identifiers)
Start:
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8,968,840 bp from pter |
End:
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8,986,558 bp from pter |
Size:
|
17,719 bases |
Orientation:
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minus strand |
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Proteins
for TMEM9B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TMM9B_HUMAN, Q9NQ34 (See
protein sequence)Recommended Name: Transmembrane protein 9B precursor Size: 198 amino acids; 22531 Da
Subcellular location: Membrane; Single-pass membrane protein (Potential)Explore the universe of human proteins at neXtProt for TMEM9B: NX_Q9NQ34
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NQ34
TMEM9B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_065695.1
ENSEMBL proteins: ENSP00000311842 ENSP00000433361 ENSP00000431487 ENSP00000432373 ENSP00000434961
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
TMEM9B for ontologies About GeneDecksing
TMEM9B Antibody Products:
Assay Products for TMEM9B: |
Protein
Domains /
Families
for TMEM9B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TMEM9B for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9NQ34ProtoNet protein and cluster: Q9NQ34 1 Blocks protein family: IPB008853 TMEM9
UniProtKB/Swiss-Prot: TMM9B_HUMAN, Q9NQ34Similarity: Belongs to the TMEM9 family |
Function
for TMEM9B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM9B (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM9B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TMEM9B (NM_020644) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMEM9B | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM9B |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM9B |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table
TMEM9B for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for TMEM9B:
|
Pathways & Interactions
for TMEM9B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMEM9B
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
3 Interacting proteins for TMEM9B (Q9NQ342, 3 ENSP000003118424) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table
TMEM9B for ontologies About GeneDecksing
|
Drugs & Compounds
for TMEM9B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TMEM9B
Search CenterWatch for drugs/clinical trials and news about TMEM9B / TMM9B
|
Transcripts
for TMEM9B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TMEM9B gene: NM_020644.1 Unigene Cluster for TMEM9B: TMEM9 domain family, member B Hs.501853 [show with all ESTs]Unigene Representative Sequence: BC0401245 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000309134 ENST00000534025(uc001mhe.1 uc001mhf.1 uc010rbt.1)
ENST00000525069 ENST00000528117 ENST00000530136
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM9B (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM9B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TMEM9B (NM_020644) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMEM9B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM9B |
Additional cDNA sequence: AB097017.1 AK074677.1 AK300712.1 AK310723.1 AK313065.1 AK316216.1 AY359069.1 BC015884.1 BC040124.1 15 DOTS entries: DT.417054 DT.100796706 DT.100796709 DT.100796705 DT.91647506 DT.75153424 DT.99982296 DT.91744905 DT.100768282 DT.100796704 DT.100796707 DT.95288823 DT.40219152 DT.86840803 DT.99933859 24/276 AceView cDNA sequences (see all 276): CK824902 AB097017 CR609980 BU734795 BC015884 CR605470 AA433929 AI811574 AI380868 BF057137 Z40957 CR620353 BU689212 CR613664 CR595163 BI756642 CA311788 AL543744 BM689946 BQ016669 AW469376 AI075212 AI348157 AA835017
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for TMEM9B About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | · | 8c |
|---|
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| SP1: | | | - | | - | | - | | - | | - | | | | | | | | | | - | | | | | | | | |
| SP2: | | | | | | | | | - | | - | | | | | | | | | | - | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | - | | - | | | | | | | | - | | | | | | | | |
| SP5: | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for TMEM9B
|
Expression
for TMEM9B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TMEM9B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TACTGTGATG
About this image
See TMEM9B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TMEM9B
SOURCE GeneReport for Unigene cluster: Hs.501853
SABiosciences Custom PCR Arrays for TMEM9B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM9B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TMEM9B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM9B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM9B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM9B |
Orthologs
for TMEM9B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for TMEM9B gene from 5/18 species (see all 18) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
TMEM9B1 |
TMEM9 domain family, member B |
78.84(n)
89.95(a) |
|
423051 XM_420984.3 XP_420984.1 |
lizard
(Anolis carolinensis) |
Reptilia |
TMEM9B6 |
-- |
78(a) |
1 ↔ 1 |
1(64503219-64509713) |
zebrafish
(Danio rerio) |
Actinopterygii |
wufd47d022 |
wufd47d02 |
78.53(n) |
|
325931 BC050159.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG11616 |
-- |
21(a) |
1 → many |
3R(1180822-1182467) |
worm
(Caenorhabditis elegans) |
Secernentea |
R12C12.66 |
Protein R12C12.6, isoform a |
23(a) |
1 → many |
II(6046260-6047840) |
ENSEMBL Gene Tree for TMEM9B (if available)
TreeFam Gene Tree for TMEM9B (if available) |
Paralogs
for TMEM9B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TMEM9B gene
- TMEM92
1 SIMAP similar gene for TMEM9B using alignment to 6 protein entries: TMM9B_HUMAN (see all proteins):TMEM9
TMEM9B for paralogs About GeneDecksing
|
Genomic Variants
for TMEM9B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TMEM9B (8968840 - 8986558 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for TMEM9B
1 CNV: 3837 | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for TMEM9B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TMEM9B for disorders About GeneDecksing
1  disease for TMEM9B: About MalaCardswegener's granulomatosis
Export disorders for TMEM9B gene to outside databases
|
Publications
for TMEM9B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TMEM9B gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with TMEM9B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Comparative genomic sequencing reveals a strikingly similar architecture of a conserved syntenic region on human chromosome 11p15.3 (including gene ST5) and mouse chromosome 7. (PubMed id 11528127)1, 2, 3 Amid C.... Schmidt E.R. (2001)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Wegener's granuloma harbors B lymphocytes with specif icities against a proinflammatory transmembrane protein and a tetraspanin. (PubMed id 20951001)1 Thurner L....Voswinkel J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)
|
External Searches for TMEM9B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TMEM9B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TMEM9B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TMEM9B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TMEM9B | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TMEM9B gene:
Search GeneIP for patents involving TMEM9B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TMEM9B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TMEM9B | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMEM9B | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM9B | | | OriGene Protein Over-expression Lysate for TMEM9B | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TMEM9B | | OriGene 3'-UTR Clone for TMEM9B | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM9B | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM9B | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TMEM9B | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMEM9B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM9B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMEM9B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM9B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM9B |
| |
 |  |  |  | |
| | | | Search Tocris compounds for TMEM9B |
| |  |  |  |  | | | | |
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 |
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 | | | TMEM9B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM9B |
|  |  |  | | | | Search ThermoFisher Antibodies for TMEM9B |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM9B |
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