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Aliases for TMEM9B Gene

Aliases for TMEM9B Gene

  • TMEM9 Domain Family, Member B 2 3
  • C11orf15 3 4
  • Chromosome 11 Open Reading Frame 15 2
  • Transmembrane Protein 9B 3

External Ids for TMEM9B Gene

Previous Symbols for TMEM9B Gene

  • C11orf15

Summaries for TMEM9B Gene

GeneCards Summary for TMEM9B Gene

TMEM9B is a Protein Coding gene. GO annotations related to this gene include signal transducer activity. An important paralog of this gene is TMEM9.

UniProtKB/Swiss-Prot for TMEM9B Gene

  • Enhances production of proinflammatory cytokines induced by TNF, IL1B, and TLR ligands. Has a role in TNF activation of both the NF-kappaB and MAPK pathways.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM9B Gene

Genomics for TMEM9B Gene

Genomic Location for TMEM9B Gene

8,947,201 bp from pter
8,965,011 bp from pter
17,811 bases
Minus strand

Genomic View for TMEM9B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM9B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM9B Gene

Regulatory Elements for TMEM9B Gene

Proteins for TMEM9B Gene

  • Protein details for TMEM9B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 9B
    Protein Accession:
    Secondary Accessions:
    • Q7Z649

    Protein attributes for TMEM9B Gene

    198 amino acids
    Molecular mass:
    22531 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM9B Gene


neXtProt entry for TMEM9B Gene

Proteomics data for TMEM9B Gene at MOPED

Post-translational modifications for TMEM9B Gene

Other Protein References for TMEM9B Gene

No data available for DME Specific Peptides for TMEM9B Gene

Domains for TMEM9B Gene

Protein Domains for TMEM9B Gene



  • Belongs to the TMEM9 family.:
    • Q9NQ34
genes like me logo Genes that share domains with TMEM9B: view

No data available for Gene Families for TMEM9B Gene

Function for TMEM9B Gene

Molecular function for TMEM9B Gene

UniProtKB/Swiss-Prot Function: Enhances production of proinflammatory cytokines induced by TNF, IL1B, and TLR ligands. Has a role in TNF activation of both the NF-kappaB and MAPK pathways.

Gene Ontology (GO) - Molecular Function for TMEM9B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IMP 12761501
genes like me logo Genes that share ontologies with TMEM9B: view
genes like me logo Genes that share phenotypes with TMEM9B: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TMEM9B Gene

Localization for TMEM9B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM9B Gene

Lysosome membrane; Single-pass membrane protein. Early endosome membrane; Single-pass membrane protein.

Subcellular locations from

Jensen Localization Image for TMEM9B Gene COMPARTMENTS Subcellular localization image for TMEM9B gene
Compartment Confidence
plasma membrane 2
endoplasmic reticulum 1
endosome 1
extracellular 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for TMEM9B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM9B: view

Pathways for TMEM9B Gene

SuperPathways for TMEM9B Gene

No Data Available

Interacting Proteins for TMEM9B Gene

Gene Ontology (GO) - Biological Process for TMEM9B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IMP 12761501
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IMP 12761501
genes like me logo Genes that share ontologies with TMEM9B: view

No data available for Pathways by source for TMEM9B Gene

Transcripts for TMEM9B Gene

Unigene Clusters for TMEM9B Gene

TMEM9 domain family, member B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM9B Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c
SP1: - - - - - -
SP2: - - -
SP4: - - - -
SP5: - - -

Relevant External Links for TMEM9B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM9B Gene

mRNA expression in normal human tissues for TMEM9B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TMEM9B Gene

SOURCE GeneReport for Unigene cluster for TMEM9B Gene Hs.501853

genes like me logo Genes that share expressions with TMEM9B: view

Orthologs for TMEM9B Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM9B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMEM9B 36
  • 99.83 (n)
  • 100 (a)
  • 100 (a)
(Bos Taurus)
Mammalia TMEM9B 36
  • 91.75 (n)
  • 95.45 (a)
  • 95 (a)
(Canis familiaris)
Mammalia TMEM9B 36
  • 93.43 (n)
  • 96.46 (a)
  • 96 (a)
(Mus musculus)
Mammalia Tmem9b 36
  • 90.76 (n)
  • 97.59 (a)
Tmem9b 16
Tmem9b 37
  • 94 (a)
(Monodelphis domestica)
Mammalia TMEM9B 37
  • 84 (a)
(Ornithorhynchus anatinus)
Mammalia TMEM9B 37
  • 75 (a)
(Rattus norvegicus)
Mammalia Tmem9b 36
  • 90.86 (n)
  • 98.39 (a)
(Gallus gallus)
Aves TMEM9B 36
  • 82.22 (n)
  • 95.76 (a)
  • 87 (a)
(Anolis carolinensis)
Reptilia TMEM9B 37
  • 78 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5088 36
(Danio rerio)
Actinopterygii tmem9b 36
  • 76.16 (n)
  • 86.06 (a)
tmem9b 37
  • 76 (a)
wufd47d02 36
(Caenorhabditis elegans)
Secernentea R12C12.6 37
  • 22 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 34 (a)
Species with no ortholog for TMEM9B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TMEM9B Gene

Gene Tree for TMEM9B (if available)
Gene Tree for TMEM9B (if available)

Paralogs for TMEM9B Gene

Paralogs for TMEM9B Gene

Selected SIMAP similar genes for TMEM9B Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with TMEM9B: view

Variants for TMEM9B Gene

Sequence variations from dbSNP and Humsavar for TMEM9B Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs4769 -- 8,947,338(+) GGACA(G/T)AGGAA utr-variant-3-prime
rs10279 -- 8,947,762(-) ACTGT(A/G)TTATC utr-variant-3-prime
rs1347016 -- 8,962,504(+) CACAT(A/G)GTAAG intron-variant
rs2060157 -- 8,950,282(-) TGTTT(C/T)GAGAC intron-variant
rs2116510 -- 8,961,737(+) CCAGA(C/T)AAACG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM9B Gene

Variant ID Type Subtype PubMed ID
nsv7215 OTHER Inversion 18451855
nsv499766 OTHER Inversion 21111241
essv24306 CNV CNV 17122850
nsv435923 CNV Deletion 17901297
nsv832062 CNV Loss 17160897

Relevant External Links for TMEM9B Gene

HapMap Linkage Disequilibrium report

Disorders for TMEM9B Gene

No disorders were found for TMEM9B Gene.

No data available for UniProtKB/Swiss-Prot for TMEM9B Gene

Publications for TMEM9B Gene

  1. Comparative genomic sequencing reveals a strikingly similar architecture of a conserved syntenic region on human chromosome 11p15.3 (including gene ST5) and mouse chromosome 7. (PMID: 11528127) Amid C. … Schmidt E.R. (Cytogenet. Cell Genet. 2001) 2 3 4
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  3. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z. … Henzel W.J. (Protein Sci. 2004) 3 4
  4. The lysosomal transmembrane protein 9B regulates the activity of inflammatory signaling pathways. (PMID: 18541524) Dodeller F. … Cenni B. (J. Biol. Chem. 2008) 4 23
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for TMEM9B Gene

Sources for TMEM9B Gene

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