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Aliases for TMEM99 Gene

Aliases for TMEM99 Gene

  • Transmembrane Protein 99 2 3 5

External Ids for TMEM99 Gene

Previous GeneCards Identifiers for TMEM99 Gene

  • GC17P036229
  • GC17P038975
  • GC17P034769

Summaries for TMEM99 Gene

GeneCards Summary for TMEM99 Gene

TMEM99 (Transmembrane Protein 99) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM99 Gene

Genomics for TMEM99 Gene

Regulatory Elements for TMEM99 Gene

Promoters for TMEM99 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TMEM99 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM99 Gene

Chromosome:
17
Start:
40,819,092 bp from pter
End:
40,836,274 bp from pter
Size:
17,183 bases
Orientation:
Plus strand

Genomic View for TMEM99 Gene

Genes around TMEM99 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM99 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM99 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM99 Gene

Proteins for TMEM99 Gene

  • Protein details for TMEM99 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N816-TMM99_HUMAN
    Recommended name:
    Transmembrane protein 99
    Protein Accession:
    Q8N816
    Secondary Accessions:
    • B4DQ34
    • Q96BP9

    Protein attributes for TMEM99 Gene

    Size:
    258 amino acids
    Molecular mass:
    27975 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM99 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM99 Gene

Proteomics data for TMEM99 Gene at MOPED

Post-translational modifications for TMEM99 Gene

No Post-translational modifications

Other Protein References for TMEM99 Gene

No data available for DME Specific Peptides for TMEM99 Gene

Domains & Families for TMEM99 Gene

Protein Domains for TMEM99 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for TMEM99 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM99: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TMEM99 Gene

Function for TMEM99 Gene

Phenotypes for TMEM99 Gene

GenomeRNAi human phenotypes for TMEM99:
genes like me logo Genes that share phenotypes with TMEM99: view

Animal Model Products

CRISPR Products

miRNA for TMEM99 Gene

miRTarBase miRNAs that target TMEM99

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM99 Gene

Localization for TMEM99 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM99 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM99 Gene COMPARTMENTS Subcellular localization image for TMEM99 gene
Compartment Confidence
plasma membrane 3

No data available for Gene Ontology (GO) - Cellular Components for TMEM99 Gene

Pathways & Interactions for TMEM99 Gene

SuperPathways for TMEM99 Gene

No Data Available

Interacting Proteins for TMEM99 Gene

Gene Ontology (GO) - Biological Process for TMEM99 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM99 Gene

Drugs & Compounds for TMEM99 Gene

No Compound Related Data Available

Transcripts for TMEM99 Gene

Unigene Clusters for TMEM99 Gene

Transmembrane protein 99:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM99 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c
SP1: - - -
SP2: - -
SP3: -
SP4: -

Relevant External Links for TMEM99 Gene

GeneLoc Exon Structure for
TMEM99
ECgene alternative splicing isoforms for
TMEM99

Expression for TMEM99 Gene

mRNA expression in normal human tissues for TMEM99 Gene

mRNA differential expression in normal tissues according to GTEx for TMEM99 Gene

This gene is overexpressed in Testis (x6.6) and Skin - Sun Exposed (Lower leg) (x4.2).

SOURCE GeneReport for Unigene cluster for TMEM99 Gene Hs.744059

genes like me logo Genes that share expression patterns with TMEM99: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TMEM99 Gene

Orthologs for TMEM99 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for TMEM99 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM99 35
  • 98.58 (n)
  • 97.67 (a)
Species with no ortholog for TMEM99:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TMEM99 Gene

ENSEMBL:
Gene Tree for TMEM99 (if available)
TreeFam:
Gene Tree for TMEM99 (if available)

Paralogs for TMEM99 Gene

No data available for Paralogs for TMEM99 Gene

Variants for TMEM99 Gene

Sequence variations from dbSNP and Humsavar for TMEM99 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs17474506 - 40,834,528(+) GGCAT(C/G)CTCCC reference, missense
rs10558 - 40,834,751(+) TTCGC(A/C/T)ATCTT reference, missense
rs1044806 - 40,834,800(+) AGGAC(A/G/T)TCTTC reference, missense
rs6694 -- 40,834,780(+) TGCGG(A/T)CATCG reference, synonymous-codon
rs2240078 -- 40,834,582(-) GAGGG(C/G)ACATA reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for TMEM99 Gene

Variant ID Type Subtype PubMed ID
nsv908226 CNV Loss 21882294

Variation tolerance for TMEM99 Gene

Residual Variation Intolerance Score: 46.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.01; 74.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM99 Gene

HapMap Linkage Disequilibrium report
TMEM99

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM99 Gene

Disorders for TMEM99 Gene

Relevant External Links for TMEM99

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM99

No disorders were found for TMEM99 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM99 Gene

Publications for TMEM99 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. A germline-specific class of small RNAs binds mammalian Piwi proteins. (PMID: 16751776) Girard A. … Carmell M.A. (Nature 2006) 3
  4. Decoding the fine-scale structure of a breast cancer genome and transcriptome. (PMID: 16461635) Volik S. … Collins C. (Genome Res. 2006) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for TMEM99 Gene

Sources for TMEM99 Gene

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