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Aliases for TMEM99 Gene

Aliases for TMEM99 Gene

  • Transmembrane Protein 99 2 3 5

External Ids for TMEM99 Gene

Previous GeneCards Identifiers for TMEM99 Gene

  • GC17P036229
  • GC17P038975
  • GC17P034769

Summaries for TMEM99 Gene

GeneCards Summary for TMEM99 Gene

TMEM99 (Transmembrane Protein 99) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM99 Gene

Genomics for TMEM99 Gene

Regulatory Elements for TMEM99 Gene

Enhancers for TMEM99 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F040509 1.7 FANTOM5 Ensembl ENCODE 23.6 -307.5 -307455 4.3 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZNF302 ZNF143 SNORD124 TMEM99 IGFBP4 RPL23AP75 MSL1 TOP2A CDC6 RARA PNMT TNS4
GH17F040306 1.7 FANTOM5 ENCODE 23.6 -501.6 -501567 22.8 CREB3L1 ZFP64 FEZF1 DMAP1 YBX1 YY1 ZNF143 ZNF263 SP3 NFYC ENSG00000266469 MED1 CDK12 SNORD124 RARA TMEM99 MSL1 LOC105371776 KRTAP9-2 CDC6
GH17F040848 1.2 Ensembl ENCODE 32.4 +33.0 32962 6.9 PKNOX1 ATF1 ZNF133 FEZF1 CBX5 FOS YY2 JUNB REST TSHZ1 TMEM99 KRT20 KRT28 ENSG00000234477 KRT37 LOC100505782 KRT31 MED24 GC17P040912 ENSG00000265359
GH17F040846 1 FANTOM5 35 +27.9 27871 0.1 HDAC1 ATF1 PKNOX1 ARNT NFRKB NFXL1 ZBTB40 RFX5 ZNF766 GATA2 TMEM99 KRT10 KRT28 KRT27 KRT26 ENSG00000234477 KRT222 SMARCE1 KRTAP2-1 LOC105371777
GH17F040908 1.7 FANTOM5 Ensembl ENCODE 18.5 +93.9 93884 8.7 PKNOX1 ATF1 MLX ZFP64 ARID4B ZNF48 ZNF121 ZNF143 FOS DEK KRT23 TMEM99 KRTAP3-2 ENSG00000259623 KRT20 KRT37 KRT28 KRT40 LOC100505782 KRT31
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM99 on UCSC Golden Path with GeneCards custom track

Promoters for TMEM99 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001346108 9 2600 ATF1 PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF48 ELK1 GATA2

Genomic Location for TMEM99 Gene

Chromosome:
17
Start:
40,819,092 bp from pter
End:
40,836,274 bp from pter
Size:
17,183 bases
Orientation:
Plus strand

Genomic View for TMEM99 Gene

Genes around TMEM99 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM99 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM99 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM99 Gene

Proteins for TMEM99 Gene

  • Protein details for TMEM99 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N816-TMM99_HUMAN
    Recommended name:
    Transmembrane protein 99
    Protein Accession:
    Q8N816
    Secondary Accessions:
    • B4DQ34
    • Q96BP9

    Protein attributes for TMEM99 Gene

    Size:
    258 amino acids
    Molecular mass:
    27975 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM99 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM99 Gene

Post-translational modifications for TMEM99 Gene

No Post-translational modifications

Other Protein References for TMEM99 Gene

No data available for DME Specific Peptides for TMEM99 Gene

Domains & Families for TMEM99 Gene

Protein Domains for TMEM99 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for TMEM99 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM99: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TMEM99 Gene

Function for TMEM99 Gene

Phenotypes for TMEM99 Gene

GenomeRNAi human phenotypes for TMEM99:
genes like me logo Genes that share phenotypes with TMEM99: view

Animal Model Products

miRNA for TMEM99 Gene

miRTarBase miRNAs that target TMEM99

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM99 Gene

Localization for TMEM99 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM99 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM99 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for TMEM99 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM99: view

Pathways & Interactions for TMEM99 Gene

SuperPathways for TMEM99 Gene

No Data Available

Interacting Proteins for TMEM99 Gene

Gene Ontology (GO) - Biological Process for TMEM99 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM99 Gene

Transcripts for TMEM99 Gene

Unigene Clusters for TMEM99 Gene

Transmembrane protein 99:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM99 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c
SP1: - - -
SP2: - -
SP3: -
SP4: -

Relevant External Links for TMEM99 Gene

GeneLoc Exon Structure for
TMEM99
ECgene alternative splicing isoforms for
TMEM99

Expression for TMEM99 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TMEM99 Gene

mRNA differential expression in normal tissues according to GTEx for TMEM99 Gene

This gene is overexpressed in Testis (x6.6) and Skin - Sun Exposed (Lower leg) (x4.2).

NURSA nuclear receptor signaling pathways regulating expression of TMEM99 Gene:

TMEM99

SOURCE GeneReport for Unigene cluster for TMEM99 Gene:

Hs.744059
genes like me logo Genes that share expression patterns with TMEM99: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for TMEM99 Gene

Orthologs for TMEM99 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for TMEM99 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM99 34
  • 98.58 (n)
Species where no ortholog for TMEM99 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TMEM99 Gene

ENSEMBL:
Gene Tree for TMEM99 (if available)
TreeFam:
Gene Tree for TMEM99 (if available)

Paralogs for TMEM99 Gene

No data available for Paralogs for TMEM99 Gene

Variants for TMEM99 Gene

Sequence variations from dbSNP and Humsavar for TMEM99 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs267607384 Pathogenic 40,818,974(-) AGCGG(-/CG)GCCAC upstream-variant-2KB, reference, frameshift-variant
rs387906640 Pathogenic 40,819,609(-) GAGTG(A/C)CAGAA intron-variant, reference, stop-gained
rs57784225 Pathogenic 40,822,126(-) ATCTG(A/C)ATGAC intron-variant, reference, missense
rs58026994 Pathogenic 40,819,565(-) CCGAC(A/T)GGAGA intron-variant, reference, missense
rs58075662 Pathogenic 40,822,119(-) TGACC(A/C/G/T)CCTGG intron-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for TMEM99 Gene

Variant ID Type Subtype PubMed ID
nsv1146669 OTHER inversion 26484159

Variation tolerance for TMEM99 Gene

Residual Variation Intolerance Score: 46.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.01; 74.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM99 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM99

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM99 Gene

Disorders for TMEM99 Gene

Relevant External Links for TMEM99

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM99

No disorders were found for TMEM99 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM99 Gene

Publications for TMEM99 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  4. Decoding the fine-scale structure of a breast cancer genome and transcriptome. (PMID: 16461635) Volik S. … Collins C. (Genome Res. 2006) 3 64
  5. A germline-specific class of small RNAs binds mammalian Piwi proteins. (PMID: 16751776) Girard A. … Carmell M.A. (Nature 2006) 3 64

Products for TMEM99 Gene

Sources for TMEM99 Gene

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