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Aliases for TMEM98 Gene

Aliases for TMEM98 Gene

  • Transmembrane Protein 98 2 3
  • Protein TADA1 4
  • TADA1 3

External Ids for TMEM98 Gene

Summaries for TMEM98 Gene

Entrez Gene Summary for TMEM98 Gene

  • This gene encodes a transmembrane protein. A missense mutation in this gene result in Nanophthalmos 4 (NNO4). Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2014]

GeneCards Summary for TMEM98 Gene

TMEM98 is a Protein Coding gene. Diseases associated with TMEM98 include nanophthalmos 4 and microphthalmia. Among its related pathways are RNA Polymerase I Promoter Opening and RNA Polymerase I Promoter Opening.

Gene Wiki entry for TMEM98 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM98 Gene

Genomics for TMEM98 Gene

Genomic Location for TMEM98 Gene

32,927,910 bp from pter
32,945,106 bp from pter
17,197 bases
Plus strand

Genomic View for TMEM98 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM98 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM98 Gene

Regulatory Elements for TMEM98 Gene

Proteins for TMEM98 Gene

  • Protein details for TMEM98 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 98
    Protein Accession:
    Secondary Accessions:
    • E1P631
    • Q9UFK2

    Protein attributes for TMEM98 Gene

    226 amino acids
    Molecular mass:
    24611 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM98 Gene

Proteomics data for TMEM98 Gene at MOPED

Post-translational modifications for TMEM98 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TMEM98 Gene

Domains for TMEM98 Gene

Protein Domains for TMEM98 Gene


Suggested Antigen Peptide Sequences for TMEM98 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TMEM98 family.:
    • Q9Y2Y6
genes like me logo Genes that share domains with TMEM98: view

No data available for Gene Families for TMEM98 Gene

Function for TMEM98 Gene

genes like me logo Genes that share phenotypes with TMEM98: view

miRNA for TMEM98 Gene

miRTarBase miRNAs that target TMEM98

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for TMEM98 Gene

Localization for TMEM98 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM98 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Jensen Localization Image for TMEM98 Gene COMPARTMENTS Subcellular localization image for TMEM98 gene
Compartment Confidence
endoplasmic reticulum 4
extracellular 3
cytosol 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for TMEM98 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM98: view

Pathways for TMEM98 Gene

genes like me logo Genes that share pathways with TMEM98: view

Pathways by source for TMEM98 Gene

Interacting Proteins for TMEM98 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: Q9Y2Y6-TMM98_HUMAN ENSP00000378138 for TMEM98 Gene via MINT STRING I2D

Gene Ontology (GO) - Biological Process for TMEM98 Gene


Transcripts for TMEM98 Gene

Unigene Clusters for TMEM98 Gene

Transmembrane protein 98:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM98 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b
SP1: - -
SP2: - -
SP3: - - -
SP4: -
SP5: - -

Relevant External Links for TMEM98 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM98 Gene

mRNA expression in normal human tissues for TMEM98 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TMEM98 Gene

SOURCE GeneReport for Unigene cluster for TMEM98 Gene Hs.3447

mRNA Expression by UniProt/SwissProt for TMEM98 Gene

Tissue specificity: Expressed in the eye, particularly in corneal endothelium, iris, ciliary body, sclera, optic nerve, optic nerve head, and retina.
genes like me logo Genes that share expressions with TMEM98: view

No data available for mRNA differential expression in normal tissues for TMEM98 Gene

Orthologs for TMEM98 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM98 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMEM98 35
  • 99.85 (n)
  • 100 (a)
TMEM98 36
  • 100 (a)
(Bos Taurus)
Mammalia TMEM98 35
  • 90.41 (n)
  • 98.23 (a)
TMEM98 36
  • 99 (a)
(Canis familiaris)
Mammalia TMEM98 35
  • 90.56 (n)
  • 96.46 (a)
TMEM98 36
  • 96 (a)
(Mus musculus)
Mammalia Tmem98 35
  • 88.5 (n)
  • 98.67 (a)
Tmem98 16
Tmem98 36
  • 99 (a)
(Monodelphis domestica)
Mammalia TMEM98 36
  • 96 (a)
(Ornithorhynchus anatinus)
Mammalia TMEM98 36
  • 94 (a)
(Rattus norvegicus)
Mammalia Tmem98 35
  • 89.23 (n)
  • 98.67 (a)
(Anolis carolinensis)
Reptilia TMEM98 36
  • 85 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem98 35
  • 74.48 (n)
  • 86.28 (a)
(Danio rerio)
Actinopterygii tmem98 35
  • 74.5 (n)
  • 84.33 (a)
tmem98 36
  • 83 (a)
(Caenorhabditis elegans)
Secernentea K10C3.4 36
  • 15 (a)
Species with no ortholog for TMEM98:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMEM98 Gene

Gene Tree for TMEM98 (if available)
Gene Tree for TMEM98 (if available)

Paralogs for TMEM98 Gene Pseudogenes for TMEM98 Gene

genes like me logo Genes that share paralogs with TMEM98: view

No data available for Paralogs for TMEM98 Gene

Variants for TMEM98 Gene

Sequence variations from dbSNP and Humsavar for TMEM98 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs9772 -- 32,941,360(-) TGACC(A/G)ATCGA utr-variant-3-prime
rs11851 -- 32,941,411(-) TTCAA(C/T)TGATT utr-variant-3-prime
rs28258 -- 32,941,006(-) GCTGC(A/T)GGCCT utr-variant-3-prime
rs28259 -- 32,940,997(-) CTGTA(A/G)GCACT utr-variant-3-prime
rs28919 -- 32,941,093(+) CTCCA(C/T)GGCTG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TMEM98 Gene

Variant ID Type Subtype PubMed ID
nsv510705 CNV Loss 20534489
nsv833417 CNV Gain 17160897
esv24161 CNV Loss 19812545
esv2667652 CNV Deletion 23128226

Relevant External Links for TMEM98 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM98 Gene

Disorders for TMEM98 Gene


  • Nanophthalmos 4 (NNO4) [MIM:615972]: A rare disorder of eye development characterized by extreme hyperopia (farsightedness) and small functional eyes. The cornea and lens are normal in size and shape. Hyperopia occurs because insufficient growth along the visual axis places these lensing components too close to the retina. Nanophthalmic eyes show considerable thickening of both the choroidal vascular bed and scleral coat, which provide nutritive and structural support for the retina. {ECO:0000269 PubMed:24852644}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for TMEM98 Gene

Relevant External Links for TMEM98

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with TMEM98: view

Publications for TMEM98 Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4
  2. Mutation in TMEM98 in a large white kindred with autosomal dominant nanophthalmos linked to 17p12-q12. (PMID: 24852644) Awadalla M.S. … Craig J.E. (JAMA Ophthalmol. 2014) 3 4
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. From ORFeome to biology: a functional genomics pipeline. (PMID: 15489336) Wiemann S. … Poustka A. (Genome Res. 2004) 3

Products for TMEM98 Gene

Sources for TMEM98 Gene

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