TMEM98 Gene
protein-coding GIFtS: 45
GCID: GC17P031254
|
|
transmembrane protein 98
| |
Aliases
for TMEM98 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Transmembrane Protein 981 2 | | DKFZP564K19641 | | Protein TADA13 |
Export aliases for TMEM98 gene to outside databasesPrevious GC identifers: GC17P028280 GC17P027440 |
Summaries
for TMEM98 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Gene Wiki entry for TMEM98
|
Genomic Views
for TMEM98 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010799.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TMEM98 gene promoter:
RFX1 AML1a GCNF HNF-4alpha1 YY1 C/EBPalpha GCNF-1 Pax-4a GCNF-2 ATF6
Other transcription factors
Search SABiosciences Chromatin IP Primers for TMEM98
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM98 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q11.2 Ensembl cytogenetic band: 17q11.2 HGNC cytogenetic band: 17q11.2TMEM98 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P031254: view genomic region
(about GC identifiers)
Start:
|
31,254,928 bp from pter |
End:
|
31,272,124 bp from pter |
Size:
|
17,197 bases |
Orientation:
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plus strand |
|
Proteins
for TMEM98 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TMM98_HUMAN, Q9Y2Y6 (See
protein sequence)Recommended Name: Transmembrane protein 98 Size: 226 amino acids; 24611 Da
Subcellular location: Membrane; Single-pass membrane protein (Potential)
Secondary accessions: E1P631 Q9UFK2Explore the universe of human proteins at neXtProt for TMEM98: NX_Q9Y2Y6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9Y2Y6
TMEM98 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001028676.1 NP_056359.2
ENSEMBL proteins: ENSP00000378138 ENSP00000463245 ENSP00000398446 ENSP00000261713 ENSP00000464537 ENSP00000406394 ENSP00000463539
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005783 | endoplasmic reticulum |
IDA | -- | | GO:0016021 | integral to membrane |
IEA | -- |
TMEM98 for ontologies About GeneDecksing
TMEM98 Antibody Products:
Assay Products for TMEM98: |
Protein
Domains /
Families
for TMEM98 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q9Y2Y6 UniProtKB/Swiss-Prot: TMM98_HUMAN, Q9Y2Y6Similarity: Belongs to the TMEM98 family |
Function
for TMEM98 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM98 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM98 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): TMEM98 (NM_001033504) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMEM98 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM98 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM98 |
Animal Models:
Mouse knock-out Tmem98tm1Lex for TMEM98
4 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Tmem98):
TMEM98 for phenotypes About GeneDecksing
|
Pathways & Interactions
for TMEM98 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMEM98
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
3 Interacting proteins for TMEM98 (Q9Y2Y62, 3 ENSP000002617134) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for TMEM98 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TMEM98
Search CenterWatch for drugs/clinical trials and news about TMEM98 / TMM98
|
Transcripts
for TMEM98 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TMEM98 gene (2 alternative transcripts): NM_001033504.1 NM_015544.2 Unigene Cluster for TMEM98: Transmembrane protein 98 Hs.3447 [show with all ESTs]Unigene Representative Sequence: NM_0155449 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000394642 ENST00000579849(uc002hhq.3 uc002hhr.3) ENST00000395149
ENST00000261713 ENST00000582227 ENST00000578289 ENST00000439138 ENST00000583437
ENST00000583120
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM98 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM98 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): TMEM98 (NM_001033504) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMEM98 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM98 |
Additional cDNA sequence: AF132000.1 AK313569.1 AL117619.1 AY358573.1 BC000526.2 BC106911.2 CR457125.1 15 DOTS entries: DT.449090 DT.100845365 DT.75161139 DT.100696604 DT.100026876 DT.100845368 DT.100805656 DT.100845364 DT.95126505 DT.75162489 DT.95126502 DT.95126506 DT.100026877 DT.102824633 DT.95126499 24/294 AceView cDNA sequences (see all 294): AA341436 BE466285 AA373071 BC000526 CR590271 AL043597 BX391257 AA722964 CR613996 CR597844 CR606539 CR608592 BU542658 CN482490 CR617078 BF220144 BF525463 CR608363 CR605381 BM718803 BX406898 BM680696 BM704388 BI823508
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for TMEM98 (see all 6) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b |
|---|
|
| SP1: | | | | | - | | - | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | - | | - | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | - | | - | | - | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | - | | - | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for TMEM98
|
Expression
for TMEM98 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TMEM98 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAGGCCCCTG
About this image
See TMEM98 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TMEM98
SOURCE GeneReport for Unigene cluster: Hs.3447
SABiosciences Custom PCR Arrays for TMEM98
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM98
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TMEM98 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM98 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM98 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM98 |
Orthologs
for TMEM98 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for TMEM98 gene from 4/13 species (see all 13) About this table
ENSEMBL Gene Tree for TMEM98 (if available)
TreeFam Gene Tree for TMEM98 (if available) |
Paralogs
for TMEM98 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TMEM98 gene
TMEM98 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for TMEM98
PGOHUM00000247813 PGOHUM00000243233
|
Genomic Variants
for TMEM98 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TMEM98 (31254928 - 31272124 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for TMEM98
1 CNV: 67176 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMEM98 |
|
Disorders
/ Diseases
for TMEM98 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TMEM98 for disorders About GeneDecksing
2  diseases for TMEM98: About MalaCardsadenosquamous carcinoma carcinoma
1 disease from the University of Copenhagen DISEASES database for TMEM98:Adenosquamous carcinoma Export disorders for TMEM98 gene to outside databases
|
Publications
for TMEM98 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TMEM98 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with TMEM98) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2, 3 Wiemann S.... Poustka A. (2001)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
- The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (2006)
- From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336)1 Wiemann S....Poustka A. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
- Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. (PubMed id 11256614)1 Simpson J.C.... Wiemann S. (2000)
|
External Searches for TMEM98 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TMEM98 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TMEM98 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TMEM98 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TMEM98 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TMEM98 gene:
Search GeneIP for patents involving TMEM98
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TMEM98 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TMEM98 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMEM98 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM98 | | | OriGene Protein Over-expression Lysate for TMEM98 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TMEM98 | | OriGene 3'-UTR Clone for TMEM98 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM98 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM98 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for TMEM98 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TMEM98 | | OriGene Custom Protein Services for TMEM98 | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TMEM98 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMEM98 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM98 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMEM98 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM98 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM98 |
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 |  |  |  | |
| | | | Search Tocris compounds for TMEM98 |
| |  |  |  |  | | | | |
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 |
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 | | | TMEM98 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM98 |
|  |  |  | | | | Search ThermoFisher Antibodies for TMEM98 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM98 |
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