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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TMEM97 Gene

protein-coding GIFtS: 48
GCID: GC17P026647

transmembrane protein 97

Explore 7 diseases affiliated with
TMEM97 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Transmembrane Protein 97¹ ²
MAC30¹ ² ³ ⁵
Protein MAC30³

External Ids:	HGNC: 28106¹	Entrez Gene: 27346²	Ensembl: ENSG00000109084⁷	OMIM: 612912⁵	UniProtKB: Q5BJF2³

Export aliases for TMEM97 gene to outside databases

Previous GC identifers: GC17P023671 GC17P022854

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TMEM97:

TMEM97 is a conserved integral membrane protein that plays a role in controlling cellular cholesterol levels (Bartz et

al., 2009 (PubMed 19583955)).(supplied by OMIM, Aug 2009)

UniProtKB/Swiss-Prot: TMM97_HUMAN, Q5BJF2

Function: Plays a role as a regulator of cellular cholesterol homeostasis

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000017.10 NC_018928.1 NT_010799.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TMEM97 gene promoter:
C/EBPbeta Brachyury FOXD3 CUTL1 AREB6 Cart-1 TGIF Zic3 Pax-4a En-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TMEM97 promoter sequence

Search SABiosciences Chromatin IP Primers for TMEM97

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM97

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q11.2 Ensembl cytogenetic band: 17q11.2 HGNC cytogenetic band: 17q11.2

TMEM97 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM97 gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17P026647: view genomic region (about GC identifiers)

Start:	26,646,121 bp from pter	End:	26,655,711 bp from pter
Size:	9,591 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TMM97_HUMAN, Q5BJF2 (See protein sequence)

Recommended Name: Transmembrane protein 97

Size: 176 amino acids; 20848 Da

Subunit: Interacts with NPC1

Subcellular location: Nucleus membrane. Rough endoplasmic reticulum. Cell membrane. Lysosome. Membrane; Multi-pass

membrane protein (Potential). Note=Localized in sterol-depleted cells at cell membrane and in lysosomes

Sequence caution: Sequence=AAA16188.1; Type=Frameshift; Positions=5;

Secondary accessions: B4DS02 Q07823

Explore the universe of human proteins at neXtProt for TMEM97: NX_Q5BJF2

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q5BJF2

TMEM97 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_055388.2

ENSEMBL proteins:

ENSP00000226230 ENSP00000466211 ENSP00000462827 ENSP00000462924 ENSP00000466987

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
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	OriGene Purified Protein: TMEM97 OriGene Protein Over-expression Lysate: TMEM97 OriGene Custom Protein Services for TMEM97
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	Novus Biologicals TMEM97 Proteins Novus Biologicals TMEM97 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for TMEM97

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IDA	--
GO:0005764	lysosome	IDA	19583955
GO:0005791	rough endoplasmic reticulum	IDA	19583955
GO:0005886	plasma membrane	IDA	--
GO:0016021	integral to membrane	IEA	--

TMEM97 for ontologies About GeneDecksing

TMEM97 Antibody Products:

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	OriGene Antibodies: TMEM97 OriGene Custom Antibody Services for TMEM97
	GenScript Custom Superior Antibodies Services for TMEM97
	Novus Biologicals TMEM97 Antibodies
	Search for Antibodies for TMEM97 at Abcam
	Uscn Antibodies for TMEM97
	ThermoFisher Antibody for TMEM97

Assay Products for TMEM97:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for TMEM97
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for TMEM97

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TMEM97 for domains About GeneDecksing

1 InterPro domain/family:

IPR016964 Transmembrane_6/97

Graphical View of Domain Structure for InterPro Entry Q5BJF2

ProtoNet protein and cluster: Q5BJF2

UniProtKB/Swiss-Prot: TMM97_HUMAN, Q5BJF2

Similarity: Belongs to the TMEM97 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: TMM97_HUMAN, Q5BJF2

Function: Plays a role as a regulator of cellular cholesterol homeostasis

Induction: Up-regulated in ovarian surface epithelial (OSE) cells with progesterone

miRNA Products:		OriGene 3'-UTR Clone: TMEM97 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TMEM97
		8/31 QIAGEN miScript miRNA Assays for microRNAs that regulate TMEM97 (see all 31):
		hsa-miR-30c hsa-miR-4291 hsa-miR-34b* hsa-miR-607 hsa-miR-3942-5p hsa-miR-30d hsa-miR-449a hsa-miR-105

		SwitchGear 3'UTR luciferase reporter plasmid: TMEM97 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMEM97 (see all 7) OriGene shRNA RFP: TMEM97 OriGene siRNA: TMEM97
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMEM97

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for TMEM97

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM97 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM97 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: TMEM97 (NM_014573)
		Sino Biological Human cDNA Clone for TMEM97
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMEM97
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM97

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for TMEM97
		Search LifeMap BioReagents cell lines for TMEM97

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM97

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	19583955

TMEM97 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for TMEM97:

Decreased Wnt reporter activit

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for TMEM97

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

2 Interacting proteins for TMEM97 (ENSP00000226230⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ELAVL1	ENSP00000385269⁴	STRING: ENSP00000385269
UBC	ENSP00000344818⁴	STRING: ENSP00000344818

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001558	regulation of cell growth	NAS	7694637
GO:0042632	cholesterol homeostasis	IDA	19583955

TMEM97 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TMEM97
Search CenterWatch for drugs/clinical trials and news about TMEM97 / TMM97

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TMEM97 gene:

NM_014573.2

Unigene Cluster for TMEM97:

Transmembrane protein 97

Hs.199695 [show with all ESTs]

Unigene Representative Sequence: NM_014573

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000226230(uc002hat.3) ENST00000583381 ENST00000582113 ENST00000582384

ENST00000336687

miRNA Products:		OriGene 3'-UTR Clone: TMEM97 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TMEM97
		8/31 QIAGEN miScript miRNA Assays for microRNAs that regulate TMEM97 (see all 31):
		hsa-miR-30c hsa-miR-4291 hsa-miR-34b* hsa-miR-607 hsa-miR-3942-5p hsa-miR-30d hsa-miR-449a hsa-miR-105

		SwitchGear 3'UTR luciferase reporter plasmid: TMEM97 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMEM97 (see all 7) OriGene shRNA RFP: TMEM97 OriGene siRNA: TMEM97
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMEM97

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM97 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM97 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: TMEM97 (NM_014573)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMEM97
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM97

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM97 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat TMEM97
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM97
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM97

Additional cDNA sequence:

AK293331.1 AK299511.1 AK307678.1 BC017362.2 BC045655.1 BC091504.1 L19183.1

16 DOTS entries:

DT.100659018 DT.100659010 DT.100659021 DT.100659006 DT.100850801 DT.455924 DT.95164200 DT.95164201

DT.100659008 DT.100682737 DT.120958024 DT.95317315 DT.100856918 DT.120958049 DT.100659015 DT.91747533

24/347 AceView cDNA sequences (see all 347):

BP871115 AI383346 CR613993 BU181078 AI638605 BM684370 BF194724 AI392867

AA457558 F10591 CD171622 AA701538 CB128985 AI917460 AA600122 CR590967

AW273409 BG388735 BQ431445 AU128141 AL599027 BF058691 BF057271 AI623312

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for TMEM97 About this scheme

ExUns:	1a	·	1b	^	2	^	3a	·	3b
SP1:
SP2:

ECgene alternative splicing isoforms for TMEM97

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TMEM97 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTGCGGAGCC

About this image

TMEM97 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

9 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Bone

Rostral Endochondral Facial Bones

Bone

Rostral Skull Membranous Bones

Bone

Bone

Cartilage

Cartilage

Rostral Chondrocranium

Cartilage

Rostral Synchondroses

Cartilage

Synchondroses

Cartilage

Head Mesenchyme

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See TMEM97 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TMEM97

SOURCE GeneReport for Unigene cluster: Hs.199695

UniProtKB/Swiss-Prot: TMM97_HUMAN, Q5BJF2

Tissue specificity: Widely expressed in normal tissues. Expressed in pancreatic, renal, breast, colon, ovarian surface

epithelial (OSE) cells and meningioma cancers. Expressed in ovarian cancer; expression is reduced relative to OSE

cells

SABiosciences Custom PCR Arrays for TMEM97

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM97 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat TMEM97
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM97
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM97

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM97

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for TMEM97 gene from 5/15 species (see all 15) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Tmem97^{1 , 5}	transmembrane protein 97^{1, 5}	82.39(n)¹ 82.39(a)¹		11 (46.74 cM)⁵ 69071¹ NM_133706.2¹ NP_598467.1¹ 78541817⁵
chicken (Gallus gallus)	Aves	TMEM97¹	transmembrane protein 97	64.26(n) 62.05(a)		417670 XM_415916.3 XP_415916.1
zebrafish (Danio rerio)	Actinopterygii	Dr.26863²	Transcribed sequence with weak similarity to protein more	76.4(n)		CF102030.1
thale cress (Arabidopsis thaliana)	eudicotyledons	AT2G32380⁶ AT1G05210⁶ (see all 3)	putative transmembrane protein 97 (see all 3)	26(a) 25(a) (see all 3)	many → 1 many → 1 (see all 3)	2(13746611-13747791) 1(1510404-1511683)
rice (Oryza sativa)	Liliopsida	-- -- (see all 3)	expressed protein (see all 3)	26(a) 25(a) (see all 3)	many → 1 many → 1 (see all 3)	7(15989889-15993114) 7(15981518-15983095)

ENSEMBL Gene Tree for TMEM97 (if available)
TreeFam Gene Tree for TMEM97 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for TMEM97 gene

TMEM97 for paralogs About GeneDecksing

2 Pseudogenes.org Pseudogenes for TMEM97
PGOHUM00000239183 PGOHUM00000249265

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs149311557^1,2		--	26644145(+)	`CTCACC/GTTCCT`	1	--	us2k¹		0	--	--	--	--
rs78163094^1,2	F,	--	26644149(+)	`CCTTCC/TTTCTG`	1	--	us2k¹		1		WA	118
rs144560063^1,2		--	26644246(+)	`ACTCCA/GTTTCA`	1	--	us2k¹		0	--	--	--	--
rs148446432^1,2		--	26644267(+)	`CCCACA/GGGCAG`	1	--	us2k¹		0	--	--	--	--
rs241776^1,2	C,F,O,A,H,	--	26644308(-)	`AGGGCG/ATGCAA`	1	--	us2k¹		19		NA MN NS EA WA CSA	1066
rs79778404^1,2		--	26644573(+)	`AATGCA/GAAGCA`	1	--	us2k¹		0	--	--	--	--
rs241775^1,2	C,F,O,A,H,	--	26644668(-)	`GCGCTG/ATGGGC`	1	--	us2k¹		28		MN NS EA NA WA CSA	2669
rs112645066^1,2	C,	--	26644704(+)	`AGCGCG/AGTGCA`	1	--	us2k¹		1		WA	2
rs200963376^1,2	C	--	26644715(-)	`GGTTAG/TGTGGG`	1	--	us2k¹		0	--	--	--	--
rs140400119^1,2		--	26644998(+)	`CAGGCA/GGGCAT`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for TMEM97 (26646121 - 26655711 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TMEM97: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMEM97

DNA2.0 Custom Variant and Variant Library Synthesis for TMEM97

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TMEM97 for disorders           About GeneDecksing

OMIM gene information: 612912    OMIM disorders: --

7 diseases for TMEM97:    About MalaCards

cholesterol ovarian cancer meningioma pancreatic cancer

colorectal cancer pancreatitis carcinoma

Export disorders for TMEM97 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TMEM97 gene, integrated from 9 sources (see all 17):
(articles sorted by number of sources associating them with TMEM97)

Utopia: connect your pdf to the dynamic
world of online information

Expression analysis of MAC30 in human pancreatic cancer and tumors of the gastrointestinal tract. (PubMed id 15375745)^{1, 2, 3} Kayed H.... Friess H. (2004)
Identification and characterization of genes differentially expressed in meningiomas. (PubMed id 7694637)^{1, 2, 3} Murphy M.... George D.L. (1993)
Coordinate up-regulation of TMEM97 and cholesterol biosynthesis genes in normal ovarian surface epithelial cells treated with progesterone: implications for pathogenesis of ovarian cancer. (PubMed id 18070364)^{1, 2, 9} Wilcox C.B....Baysal B.E. (2007)
Identification of cholesterol-regulating genes by tar geted RNAi screening. (PubMed id 19583955)^{1, 2} Bartz F....Runz H. (2009)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Significance of mRNA and protein expression of MAC30 i n progression of colorectal cancer. (PubMed id 22024687)¹ Zhao Z.R....Sun X.F. (2011)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)
A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)¹ Wagner S.A....Choudhary C. (2011)
Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)¹ OlA!h J....OvA!di J. (2011)
Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 27346	HGNC: 28106	AceView: MAC30	Ensembl:ENSG00000109084	euGenes: HUgn27346
ECgene: TMEM97	H-InvDB: TMEM97

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for TMEM97	Pharmacogenomics, SNPs, Pathways

Intellectual Property for TMEM97 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for TMEM97 gene:
Search GeneIP for patents involving TMEM97

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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	OriGene Antibodies for TMEM97		OriGene shRNA RFP for TMEM97
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMEM97		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM97
	OriGene Protein Over-expression Lysate for TMEM97		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for TMEM97		OriGene 3'-UTR Clone for TMEM97
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM97		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM97
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for TMEM97		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for TMEM97		OriGene Custom Protein Services for TMEM97
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TMEM97
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMEM97
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM97
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMEM97
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM97
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM97

	GenScript Custom Purified and Recombinant Proteins Services for TMEM97		GenScript cDNA clones with any tag delivered in your preferred vector for TMEM97
	GenScript Custom Assay Services for TMEM97		GenScript Custom Superior Antibodies Services for TMEM97
	GenScript Custom overexpressing Cell Line Services for TMEM97		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
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	Regulatory tfbs in TMEM97 promoter
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	Novus Tissue Slides
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	Search for Antibodies for TMEM97 at Abcam
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Browse ProSpec Recombinant Proteins

TMEM97 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for TMEM97

	Gene Synthesis
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM97

	SwitchGear 3'UTR luciferase reporter plasmids for TMEM97
	SwitchGear Promoter luciferase reporter plasmids for TMEM97

ThermoFisher Antibody for TMEM97

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM97

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes TMEM97 gene at Home site.

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TMEM97 Gene

transmembrane protein 97

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TMEM97 Gene

transmembrane protein 97

Aliasesfor TMEM97 gene

Summariesfor TMEM97 gene

Genomic Viewsfor TMEM97 gene

Proteinsfor TMEM97 gene

Protein Domains /Familiesfor TMEM97 gene

Functionfor TMEM97 gene

Pathways & Interactionsfor TMEM97 gene

Drugs & Compoundsfor TMEM97 gene

Transcriptsfor TMEM97 gene

Expression for TMEM97 gene

Orthologsfor TMEM97 gene

Paralogsfor TMEM97 gene

Genomic Variantsfor TMEM97 gene

Disorders / Diseasesfor TMEM97 gene

Publicationsfor TMEM97 gene

External Searches for TMEM97 gene

Genome Databases showing TMEM97 gene

Other Databases showing TMEM97 gene

Specialized Databases showing TMEM97 gene

Intellectual Propertyfor TMEM97 gene

Productsfor TMEM97 gene

View Random Gene

Aliases
for TMEM97 gene

Summaries
for TMEM97 gene

Genomic Views
for TMEM97 gene

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for TMEM97 gene

Protein Domains /
Families
for TMEM97 gene

Function
for TMEM97 gene

Pathways & Interactions
for TMEM97 gene

Drugs & Compounds
for TMEM97 gene

Transcripts
for TMEM97 gene

Expression
for TMEM97 gene

Orthologs
for TMEM97 gene

Paralogs
for TMEM97 gene

Genomic Variants
for TMEM97 gene

Disorders / Diseases
for TMEM97 gene

Publications
for TMEM97 gene

Intellectual Property
for TMEM97 gene

Products
for TMEM97 gene