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TMEM97 Gene

protein-coding   GIFtS: 50
GCID: GC17P026647

Transmembrane Protein 97

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Transmembrane Protein 971 2
MAC302 3 5
Protein MAC303

External Ids:    HGNC: 281061   Entrez Gene: 273462   Ensembl: ENSG000001090847   OMIM: 6129125   UniProtKB: Q5BJF23   

Export aliases for TMEM97 gene to outside databases

Previous GC identifers: GC17P023671 GC17P022854


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TMEM97 Gene:
TMEM97 is a conserved integral membrane protein that plays a role in controlling cellular cholesterol levels
(Bartz et al., 2009 (PubMed 19583955)).(supplied by OMIM, Aug 2009)

GeneCards Summary for TMEM97 Gene:
TMEM97 (transmembrane protein 97) is a protein-coding gene. Diseases associated with TMEM97 include meningioma, and pancreatic cancer.

UniProtKB/Swiss-Prot: TMM97_HUMAN, Q5BJF2
Function: Plays a role as a regulator of cellular cholesterol homeostasis




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TMEM97 gene promoter:
         C/EBPbeta   Brachyury   FOXD3   CUTL1   AREB6   Cart-1   TGIF   Zic3   Pax-4a   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMEM97 promoter sequence
   Search Chromatin IP Primers for TMEM97

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TMEM97


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q11.2   Ensembl cytogenetic band:  17q11.2   HGNC cytogenetic band: 17q11.2

TMEM97 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM97 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P026647:  view genomic region     (about GC identifiers)

Start:
26,646,121 bp from pter      End:
26,655,711 bp from pter
Size:
9,591 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TMM97_HUMAN, Q5BJF2 (See protein sequence)
Recommended Name: Transmembrane protein 97  
Size: 176 amino acids; 20848 Da
Subunit: Interacts with NPC1
Sequence caution: Sequence=AAA16188.1; Type=Frameshift; Positions=5;
Secondary accessions: B4DS02 Q07823

Explore the universe of human proteins at neXtProt for TMEM97: NX_Q5BJF2

Explore proteomics data for TMEM97 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys48, Lys52, Lys130
  • Modification sites at PhosphoSitePlus

  • See TMEM97 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055388.2  
    ENSEMBL proteins: 
     ENSP00000226230   ENSP00000466211   ENSP00000462827   ENSP00000462924   ENSP00000466987  

    TMEM97 Human Recombinant Protein Products:

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    TMEM97 Assay Products:

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    Cloud-Clone Corp. CLIAs for TMEM97


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR016964 Transmembrane_6/97

    Graphical View of Domain Structure for InterPro Entry Q5BJF2

    ProtoNet protein and cluster: Q5BJF2

    UniProtKB/Swiss-Prot: TMM97_HUMAN, Q5BJF2
    Similarity: Belongs to the TMEM97 family


    TMEM97 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TMM97_HUMAN, Q5BJF2
    Function: Plays a role as a regulator of cellular cholesterol homeostasis
    Induction: Up-regulated in ovarian surface epithelial (OSE) cells with progesterone

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI19583955
         
    TMEM97 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for TMEM97:
     Decreased Wnt reporter activit 

         1 MGI phenotypic allele for Tmem97 (no phenotypes)

    TMEM97 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TMEM97
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TMEM97

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TMEM97
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TMEM97

    miRNA
    Products:
        
    miRTarBase miRNAs that target TMEM97:
    hsa-mir-20a-5p (MIRT050502), hsa-mir-7-5p (MIRT025807), hsa-mir-193b-3p (MIRT041579), hsa-mir-769-5p (MIRT039218), hsa-mir-99b-3p (MIRT038535)

    Block miRNA regulation of human, mouse, rat TMEM97 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TMEM97 (see all 31):
    hsa-miR-30c hsa-miR-4291 hsa-miR-34b* hsa-miR-607 hsa-miR-3942-5p hsa-miR-30d hsa-miR-449a hsa-miR-105
    SwitchGear 3'UTR luciferase reporter plasmidTMEM97 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for TMEM97
    Predesigned siRNA for gene silencing in human, mouse, rat TMEM97

    Gene Editing
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TMEM97 (NM_014573)
    Sino Biological Human cDNA Clone for TMEM97
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMEM97
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM97

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    Browse ESI BIO Cell Lines and PureStem Progenitors for TMEM97 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM97


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TMM97_HUMAN, Q5BJF2: Nucleus membrane. Rough endoplasmic reticulum. Cell membrane. Lysosome. Membrane; Multi-pass
    membrane protein (Potential). Note=Localized in sterol-depleted cells at cell membrane and in lysosomes
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    lysosome5
    nucleus5
    plasma membrane5
    vacuole5
    cytosol3
    peroxisome2
    extracellular1
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005764lysosome IDA19583955
    GO:0005791rough endoplasmic reticulum IDA19583955
    GO:0005886plasma membrane IDA19583955
    GO:0016021integral component of membrane IEA--

    TMEM97 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TMEM97
    Interactions:

        Search GeneGlobe Interaction Network for TMEM97

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for TMEM97 (ENSP000002262304) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PAQR3ENSP000003700194STRING: ENSP00000370019
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    UBCENSP000003448184STRING: ENSP00000344818
    TRAPPC2ENSP000003527084STRING: ENSP00000352708
    MSMO1ENSP000002615074STRING: ENSP00000261507
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001558regulation of cell growth NAS7694637
    GO:0042632cholesterol homeostasis IDA19583955

    TMEM97 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TMEM97 (TMM97)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TMEM97 gene: 
    NM_014573.2  

    Unigene Cluster for TMEM97:

    Transmembrane protein 97
    Hs.199695  [show with all ESTs]
    Unigene Representative Sequence: NM_014573
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000226230(uc002hat.3) ENST00000583381 ENST00000582113 ENST00000582384
    ENST00000336687
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TMEM97 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TMEM97 (see all 31):
    hsa-miR-30c hsa-miR-4291 hsa-miR-34b* hsa-miR-607 hsa-miR-3942-5p hsa-miR-30d hsa-miR-449a hsa-miR-105
    SwitchGear 3'UTR luciferase reporter plasmidTMEM97 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TMEM97
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TMEM97 (NM_014573)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMEM97
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM97
    Primer
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    OriGene qPCR primer pairs and template standards for TMEM97
    OriGene qSTAR qPCR primer pairs in human, mouse for TMEM97
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TMEM97
      QuantiTect SYBR Green Assays in human, mouse, rat TMEM97
      QuantiFast Probe-based Assays in human, mouse, rat TMEM97

    Additional mRNA sequence: 

    AK293331.1 AK299511.1 AK307678.1 BC017362.2 BC045655.1 BC091504.1 L19183.1 

    16 DOTS entries:

    DT.100659018  DT.100659010  DT.100659021  DT.100659006  DT.100850801  DT.455924  DT.95164200  DT.95164201 
    DT.100659008  DT.100682737  DT.120958024  DT.95317315  DT.100856918  DT.120958049  DT.100659015  DT.91747533 

    Selected AceView cDNA sequences (see all 347):

    BG696210 F07200 CD171622 AA977219 CR613993 BF437463 BM929951 BE671550 
    CB128985 BP871737 AI638605 F02326 CR590967 BF194724 BF055321 T29829 
    BF057271 BF058691 BM694290 BU181078 AA457558 BU192074 AA630740 F04910 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for TMEM97    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b
    SP1:                              
    SP2:                              


    ECgene alternative splicing isoforms for TMEM97

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TMEM97 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGCGGAGCC
    TMEM97 Expression
    About this image


    TMEM97 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             XY Germ Cells Testis Cord
     
     Bone (Muscoskeletal System)
             Rib
     
     Gonad
             XY Germ Cells Testis Cord
    TMEM97 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TMEM97 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.199695

    UniProtKB/Swiss-Prot: TMM97_HUMAN, Q5BJF2
    Tissue specificity: Widely expressed in normal tissues. Expressed in pancreatic, renal, breast, colon, ovarian
    surface epithelial (OSE) cells and meningioma cancers. Expressed in ovarian cancer; expression is reduced
    relative to OSE cells

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM97

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TMEM97 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tmem971 , 5 transmembrane protein 971, 5 81.62(n)1
    81.21(a)1
      11 (46.74 cM)5
    690711  NM_133706.21  NP_598467.11 
     785418175 
    chicken
    (Gallus gallus)
    Aves TMEM971 transmembrane protein 97 64.3(n)
    63.23(a)
      417670  XM_415916.4  XP_415916.1 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia tmem971 transmembrane protein 97 60.86(n)
    59.35(a)
      448515  NM_001005014.2  NP_001005014.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.268632 Transcribed sequence with weak similarity to protein more 76.4(n)    CF102030.1 


    ENSEMBL Gene Tree for TMEM97 (if available)
    TreeFam Gene Tree for TMEM97 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TMEM97 gene

    TMEM97 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for TMEM97
    PGOHUM00000239183 PGOHUM00000249265


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TMEM97 (see all 195)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1493115571,2
    --26644145(+) CTCACC/GTTCCT 1 -- us2k10--------
    rs781630941,2
    F--26644149(+) CCTTCC/TTTCTG 1 -- us2k11Minor allele frequency- T:0.05WA 118
    rs1445600631,2
    --26644246(+) ACTCCA/GTTTCA 1 -- us2k10--------
    rs1484464321,2
    --26644267(+) CCCACA/GGGCAG 1 -- us2k10--------
    rs2417761,2
    C,F,O,A,H--26644308(-) AGGGCG/ATGCAA 1 -- us2k119Minor allele frequency- A:0.28NA MN NS EA WA CSA 1066
    rs797784041,2
    F--26644573(+) AATGCA/GAAGCA 1 -- us2k10--------
    rs2417751,2
    C,F,O,A,H--26644668(-) GCGCTG/ATGGGC 1 -- us2k128Minor allele frequency- A:0.34MN NS EA NA WA CSA 2669
    rs1126450661,2
    C,F--26644704(+) AGCGCG/AGTGCA 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs2009633761,2
    C--26644715(-) GGTTAG/TGTGGG 1 -- us2k10--------
    rs1404001191,2
    C--26644998(+) CAGGCA/GGGCAT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TMEM97 (26646121 - 26655711 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for TMEM97:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv2017CNV Insertion18451855
    nsv519388CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TMEM97
    DNA2.0 Custom Variant and Variant Library Synthesis for TMEM97

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612912    OMIM disorders: --

    8 diseases for TMEM97:    
    About MalaCards
    meningioma    pancreatic cancer    oral squamous cell carcinoma    ovarian cancer
    colorectal cancer    pancreatitis    squamous cell carcinoma    lung cancer


    TMEM97 for disorders           About GeneDecksing


    Export disorders for TMEM97 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TMEM97 gene, integrated from 10 sources (see all 19):
    (articles sorted by number of sources associating them with TMEM97)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Expression analysis of MAC30 in human pancreatic cancer and tumors of the gastrointestinal tract. (PubMed id 15375745)1, 2, 3 Kayed H.... Friess H. (Histol. Histopathol. 2004)
    2. Identification and characterization of genes differentially expressed in meningiomas. (PubMed id 7694637)1, 2, 3 Murphy M.... George D.L. (Cell Growth Differ. 1993)
    3. Coordinate up-regulation of TMEM97 and cholesterol biosynthesis genes in normal ovarian surface epithelial cells treated with progesterone: implications for pathogenesis of ovarian cancer. (PubMed id 18070364)1, 2, 9 Wilcox C.B....Baysal B.E. (BMC Cancer 2007)
    4. Identification of cholesterol-regulating genes by targeted RNAi screening. (PubMed id 19583955)1, 2 Bartz F.... Runz H. (Cell Metab. 2009)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Elevated expression of MAC30 predicts lymph node metastasis and unfavorable prognosis in patients with epithelial ovarian cancer. (PubMed id 23254963)1 Yang S....Zhang Y. (Med. Oncol. 2013)
    7. Overexpression of MAC30 is associated with poor clinical outcome in human non-small-cell lung cancer. (PubMed id 23229099)1 Han K.Y....Li J.N. (Tumour Biol. 2013)
    8. Significance of mRNA and protein expression of MAC30 in progression of colorectal cancer. (PubMed id 22024687)1 Zhao Z.R....Sun X.F. (Chemotherapy 2011)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    10. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 27346 HGNC: 28106 AceView: MAC30 Ensembl:ENSG00000109084 euGenes: HUgn27346
    ECgene: TMEM97 H-InvDB: TMEM97

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TMEM97 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TMEM97 gene:
    Search GeneIP for patents involving TMEM97

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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