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Aliases for TMEM97 Gene

Aliases for TMEM97 Gene

  • Transmembrane Protein 97 2 3 5
  • Meningioma-Associated Protein 30 3 4
  • MAC30 3 4

External Ids for TMEM97 Gene

Previous GeneCards Identifiers for TMEM97 Gene

  • GC17P023671
  • GC17P026647
  • GC17P022854

Summaries for TMEM97 Gene

Entrez Gene Summary for TMEM97 Gene

  • TMEM97 is a conserved integral membrane protein that plays a role in controlling cellular cholesterol levels (Bartz et al., 2009 [PubMed 19583955]).[supplied by OMIM, Aug 2009]

GeneCards Summary for TMEM97 Gene

TMEM97 (Transmembrane Protein 97) is a Protein Coding gene.

UniProtKB/Swiss-Prot for TMEM97 Gene

  • Plays a role as a regulator of cellular cholesterol homeostasis (PubMed:19583955). May function as sterol isomerase (PubMed:25566323).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM97 Gene

Genomics for TMEM97 Gene

Regulatory Elements for TMEM97 Gene

Enhancers for TMEM97 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TMEM97 on UCSC Golden Path with GeneCards custom track

Promoters for TMEM97 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TMEM97 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM97 Gene

28,319,095 bp from pter
28,328,685 bp from pter
9,591 bases
Plus strand

Genomic View for TMEM97 Gene

Genes around TMEM97 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM97 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM97 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM97 Gene

Proteins for TMEM97 Gene

  • Protein details for TMEM97 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 97
    Protein Accession:
    Secondary Accessions:
    • B4DS02
    • Q07823

    Protein attributes for TMEM97 Gene

    176 amino acids
    Molecular mass:
    20848 Da
    Quaternary structure:
    • Interacts with NPC1.
    • Sequence=AAA16188.1; Type=Frameshift; Positions=5; Evidence={ECO:0000305};

neXtProt entry for TMEM97 Gene

Proteomics data for TMEM97 Gene at MOPED

Post-translational modifications for TMEM97 Gene

  • Ubiquitination at Lys 48, Lys 52, and Lys 130
  • Modification sites at PhosphoSitePlus

Other Protein References for TMEM97 Gene

Antibody Products

No data available for DME Specific Peptides for TMEM97 Gene

Domains & Families for TMEM97 Gene

Protein Domains for TMEM97 Gene


Suggested Antigen Peptide Sequences for TMEM97 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 EXPERA domain.
  • Belongs to the TMEM97 family.
  • Contains 1 EXPERA domain.
  • Belongs to the TMEM97 family.
genes like me logo Genes that share domains with TMEM97: view

No data available for Gene Families for TMEM97 Gene

Function for TMEM97 Gene

Molecular function for TMEM97 Gene

UniProtKB/Swiss-Prot Function:
Plays a role as a regulator of cellular cholesterol homeostasis (PubMed:19583955). May function as sterol isomerase (PubMed:25566323).
UniProtKB/Swiss-Prot Induction:
Up-regulated in ovarian surface epithelial (OSE) cells with progesterone.
genes like me logo Genes that share phenotypes with TMEM97: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM97 Gene

Localization for TMEM97 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM97 Gene

Nucleus membrane. Rough endoplasmic reticulum. Cell membrane. Lysosome. Membrane; Multi-pass membrane protein. Note=Localized in sterol-depleted cells at cell membrane and in lysosomes. {ECO:0000269 PubMed:19583955}.

Subcellular locations from

Jensen Localization Image for TMEM97 Gene COMPARTMENTS Subcellular localization image for TMEM97 gene
Compartment Confidence
endoplasmic reticulum 5
lysosome 5
nucleus 5
plasma membrane 5
vacuole 5
cytosol 2
peroxisome 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for TMEM97 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005764 lysosome IDA 19583955
GO:0005886 plasma membrane IDA 19583955
GO:0016021 integral component of membrane IEA --
GO:0031965 nuclear membrane IDA 19583955
genes like me logo Genes that share ontologies with TMEM97: view

Pathways & Interactions for TMEM97 Gene

SuperPathways for TMEM97 Gene

No Data Available

Interacting Proteins for TMEM97 Gene

Gene Ontology (GO) - Biological Process for TMEM97 Gene


No data available for Pathways by source and SIGNOR curated interactions for TMEM97 Gene

Drugs & Compounds for TMEM97 Gene

No Compound Related Data Available

Transcripts for TMEM97 Gene

Unigene Clusters for TMEM97 Gene

Transmembrane protein 97:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM97 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b

Relevant External Links for TMEM97 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM97 Gene

mRNA expression in normal human tissues for TMEM97 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM97 Gene

This gene is overexpressed in Pancreas (x9.3).

Protein differential expression in normal tissues from HIPED for TMEM97 Gene

This gene is overexpressed in Fetal testis (16.5), Islet of Langerhans (15.5), and Testis (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for TMEM97 Gene

SOURCE GeneReport for Unigene cluster for TMEM97 Gene Hs.199695

mRNA Expression by UniProt/SwissProt for TMEM97 Gene

Tissue specificity: Widely expressed in normal tissues. Expressed in pancreatic, renal, breast, colon, ovarian surface epithelial (OSE) cells and meningioma cancers. Expressed in ovarian cancer; expression is reduced relative to OSE cells.
genes like me logo Genes that share expression patterns with TMEM97: view

Protein tissue co-expression partners for TMEM97 Gene

Primer Products

In Situ Assay Products

Orthologs for TMEM97 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TMEM97 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TMEM97 35
  • 83.52 (n)
  • 78.41 (a)
TMEM97 36
  • 78 (a)
(Canis familiaris)
Mammalia TMEM97 35
  • 86.26 (n)
  • 84.24 (a)
TMEM97 36
  • 85 (a)
(Mus musculus)
Mammalia Tmem97 35
  • 81.62 (n)
  • 81.21 (a)
Tmem97 16
Tmem97 36
  • 82 (a)
(Pan troglodytes)
Mammalia TMEM97 35
  • 99.19 (n)
  • 98.79 (a)
TMEM220 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Tmem97 35
  • 82.63 (n)
  • 80.61 (a)
(Monodelphis domestica)
Mammalia TMEM97 36
  • 63 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 64 (a)
-- 36
  • 61 (a)
(Gallus gallus)
Aves TMEM97 35
  • 64.3 (n)
  • 63.23 (a)
TMEM97 36
  • 54 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem97 35
  • 60.86 (n)
  • 59.35 (a)
(Danio rerio)
Actinopterygii Dr.26863 35
LOC569147 35
  • 60.96 (n)
  • 65.79 (a)
tmem97 36
  • 39 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 38
Species with no ortholog for TMEM97:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM97 Gene

Gene Tree for TMEM97 (if available)
Gene Tree for TMEM97 (if available)

Paralogs for TMEM97 Gene Pseudogenes for TMEM97 Gene

genes like me logo Genes that share paralogs with TMEM97: view

No data available for Paralogs for TMEM97 Gene

Variants for TMEM97 Gene

Sequence variations from dbSNP and Humsavar for TMEM97 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs241775 -- 28,317,642(-) GCGCT(A/G)TGGGC upstream-variant-2KB
rs241776 -- 28,317,282(-) AGGGC(A/G)TGCAA upstream-variant-2KB
rs1061480 -- 28,326,981(+) ttttt(A/T)agaca utr-variant-3-prime
rs1981512 -- 28,321,466(-) AAGGA(C/T)CCTGT intron-variant
rs5819836 -- 28,319,408(+) TCCCG(-/C)GCGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM97 Gene

Variant ID Type Subtype PubMed ID
nsv519388 CNV Loss 19592680
nsv2017 CNV Insertion 18451855

Variation tolerance for TMEM97 Gene

Residual Variation Intolerance Score: 52% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.35; 7.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM97 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM97 Gene

Disorders for TMEM97 Gene

Relevant External Links for TMEM97

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TMEM97 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM97 Gene

Publications for TMEM97 Gene

  1. Expression analysis of MAC30 in human pancreatic cancer and tumors of the gastrointestinal tract. (PMID: 15375745) Kayed H. … Friess H. (Histol. Histopathol. 2004) 2 3 4 67
  2. Coordinate up-regulation of TMEM97 and cholesterol biosynthesis genes in normal ovarian surface epithelial cells treated with progesterone: implications for pathogenesis of ovarian cancer. (PMID: 18070364) Wilcox C.B. … Baysal B.E. (BMC Cancer 2007) 3 23
  3. Identification and characterization of genes differentially expressed in meningiomas. (PMID: 7694637) Murphy M. … George D.L. (Cell Growth Differ. 1993) 2 3
  4. RNA interference against TMEM97 inhibits cell proliferation, migration, and invasion in glioma cells. (PMID: 26002575) Qiu G. … Hu G. (Tumour Biol. 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for TMEM97 Gene

Sources for TMEM97 Gene