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Aliases for TMEM95 Gene

Aliases for TMEM95 Gene

  • Transmembrane Protein 95 2 3 5
  • UNQ9390 3

External Ids for TMEM95 Gene

Previous GeneCards Identifiers for TMEM95 Gene

  • GC17P007200
  • GC17P007258
  • GC17P007152

Summaries for TMEM95 Gene

GeneCards Summary for TMEM95 Gene

TMEM95 (Transmembrane Protein 95) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM95 Gene

Genomics for TMEM95 Gene

Regulatory Elements for TMEM95 Gene

Genomic Location for TMEM95 Gene

Chromosome:
17
Start:
7,355,123 bp from pter
End:
7,357,219 bp from pter
Size:
2,097 bases
Orientation:
Plus strand

Genomic View for TMEM95 Gene

Genes around TMEM95 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM95 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM95 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM95 Gene

Proteins for TMEM95 Gene

  • Protein details for TMEM95 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3KNT9-TMM95_HUMAN
    Recommended name:
    Transmembrane protein 95
    Protein Accession:
    Q3KNT9
    Secondary Accessions:
    • B7WPI7
    • Q6UXT3
    • Q8IW68

    Protein attributes for TMEM95 Gene

    Size:
    176 amino acids
    Molecular mass:
    19597 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH40900.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TMEM95 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM95 Gene

Proteomics data for TMEM95 Gene at MOPED

Post-translational modifications for TMEM95 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM95 Gene

No data available for DME Specific Peptides for TMEM95 Gene

Domains & Families for TMEM95 Gene

Protein Domains for TMEM95 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM95 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM95: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TMEM95 Gene

Function for TMEM95 Gene

genes like me logo Genes that share phenotypes with TMEM95: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMEM95 Gene

Localization for TMEM95 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM95 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM95 Gene COMPARTMENTS Subcellular localization image for TMEM95 gene
Compartment Confidence
extracellular 2
plasma membrane 2

No data available for Gene Ontology (GO) - Cellular Components for TMEM95 Gene

Pathways & Interactions for TMEM95 Gene

SuperPathways for TMEM95 Gene

No Data Available

Interacting Proteins for TMEM95 Gene

Gene Ontology (GO) - Biological Process for TMEM95 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM95 Gene

Drugs & Compounds for TMEM95 Gene

No Compound Related Data Available

Transcripts for TMEM95 Gene

mRNA/cDNA for TMEM95 Gene

(5) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMEM95 Gene

Transmembrane protein 95:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM95 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b
SP1: -
SP2:

Relevant External Links for TMEM95 Gene

GeneLoc Exon Structure for
TMEM95
ECgene alternative splicing isoforms for
TMEM95

Expression for TMEM95 Gene

mRNA expression in normal human tissues for TMEM95 Gene

mRNA differential expression in normal tissues according to GTEx for TMEM95 Gene

This gene is overexpressed in Testis (x48.9).

Protein differential expression in normal tissues from HIPED for TMEM95 Gene

This gene is overexpressed in Lung (34.5), Pancreas (24.4), and Liver, secretome (10.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM95 Gene



SOURCE GeneReport for Unigene cluster for TMEM95 Gene Hs.259432

genes like me logo Genes that share expression patterns with TMEM95: view

Protein tissue co-expression partners for TMEM95 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for TMEM95 Gene

Orthologs for TMEM95 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TMEM95 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TMEM95 35
  • 79.07 (n)
  • 67.44 (a)
dog
(Canis familiaris)
Mammalia TMEM95 35
  • 80.11 (n)
  • 70.45 (a)
mouse
(Mus musculus)
Mammalia Tmem95 35
  • 77.39 (n)
  • 65.52 (a)
Tmem95 16
Tmem95 36
  • 65 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TMEM95 35
  • 99.64 (n)
  • 99.46 (a)
TMEM95 36
  • 71 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem95 35
  • 78.32 (n)
  • 70.49 (a)
oppossum
(Monodelphis domestica)
Mammalia TMEM95 36
  • 62 (a)
OneToOne
Species with no ortholog for TMEM95:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TMEM95 Gene

ENSEMBL:
Gene Tree for TMEM95 (if available)
TreeFam:
Gene Tree for TMEM95 (if available)

Paralogs for TMEM95 Gene

No data available for Paralogs for TMEM95 Gene

Variants for TMEM95 Gene

Sequence variations from dbSNP and Humsavar for TMEM95 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs3744406 -- 7,356,349(+) GTGCG(C/T)GTGGG intron-variant
rs6503016 -- 7,355,754(+) GAGGG(C/T)TGATC intron-variant
rs9895595 -- 7,355,542(+) CAGAA(A/C)CTGGG intron-variant
rs9906417 -- 7,356,592(+) GTCTT(C/G)CCTCA intron-variant
rs35390064 -- 7,357,592(+) GAAGA(-/AGA)GGAAG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for TMEM95 Gene

Variant ID Type Subtype PubMed ID
esv2422288 CNV Deletion 17116639
nsv457659 CNV Loss 19166990
dgv3053n71 CNV Loss 21882294
nsv907642 CNV Loss 21882294
nsv907643 CNV Loss 21882294

Variation tolerance for TMEM95 Gene

Residual Variation Intolerance Score: 80.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.92; 19.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM95 Gene

HapMap Linkage Disequilibrium report
TMEM95

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM95 Gene

Disorders for TMEM95 Gene

Relevant External Links for TMEM95

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM95

No disorders were found for TMEM95 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM95 Gene

Publications for TMEM95 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4 67
  2. A nonsense mutation in TMEM95 encoding a nondescript transmembrane protein causes idiopathic male subfertility in cattle. (PMID: 24391514) Pausch H. … Fries R. (PLoS Genet. 2014) 3
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for TMEM95 Gene

Sources for TMEM95 Gene

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