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Aliases for TMEM95 Gene

Aliases for TMEM95 Gene

  • Transmembrane Protein 95 2 3 5
  • UNQ9390 3

External Ids for TMEM95 Gene

Previous GeneCards Identifiers for TMEM95 Gene

  • GC17P007200
  • GC17P007258
  • GC17P007152

Summaries for TMEM95 Gene

GeneCards Summary for TMEM95 Gene

TMEM95 (Transmembrane Protein 95) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM95 Gene

Genomics for TMEM95 Gene

Regulatory Elements for TMEM95 Gene

Enhancers for TMEM95 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F007712 0.9 FANTOM5 29.8 +357.2 357212 0.2 ATF1 ZMYM3 CHD4 BMI1 KMT2B YY1 ZNF335 GLIS2 ZNF366 POLR2A SPEM1 TMEM95 C17orf74 YBX2 DLG4 SLC35G6 CNTROB ELP5 GC17M007714 DNAH2
GH17F007474 1.6 FANTOM5 ENCODE 10.9 +125.5 125467 12.5 CREB3L1 ZFP64 YBX1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 DVL2 SNORD10 SNORA48 CHRNB1 PFAS LOC105371523 KCTD11 CTC1 CNTROB MIR6883
GH17F007380 0.8 ENCODE 12.3 +26.0 26049 1.4 ELF3 TBP DRAP1 KLF1 SAP130 TAF1 ARID4B TEAD3 ZBTB48 POLR2A CHRNB1 TMEM95 KCTD11 NLGN2 TMEM256 TMEM256-PLSCR3 SPEM1 C17orf74 ACAP1 ENSG00000224647
GH17F007383 0.6 ENCODE 12.3 +29.2 29205 1.4 ZNF664 USF1 POLR2A ZNF341 CREM KDM6A TMEM95 KCTD11 NLGN2 SPEM1 C17orf74 ACAP1 ENSG00000224647 NEURL4 EIF5A CHRNB1
GH17F007412 0.6 ENCODE 11.3 +58.4 58386 1.1 ZNF362 RFX1 ZNF366 GLIS1 ZNF600 FGF11 CHRNB1 TMEM95 ACAP1 CLDN7 ENSG00000202251 TNFSF12 TNFSF12-TNFSF13 ENSG00000224647 NEURL4
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM95 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM95 Gene

Chromosome:
17
Start:
7,355,123 bp from pter
End:
7,357,219 bp from pter
Size:
2,097 bases
Orientation:
Plus strand

Genomic View for TMEM95 Gene

Genes around TMEM95 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM95 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM95 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM95 Gene

Proteins for TMEM95 Gene

  • Protein details for TMEM95 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3KNT9-TMM95_HUMAN
    Recommended name:
    Transmembrane protein 95
    Protein Accession:
    Q3KNT9
    Secondary Accessions:
    • B7WPI7
    • Q6UXT3
    • Q8IW68

    Protein attributes for TMEM95 Gene

    Size:
    176 amino acids
    Molecular mass:
    19597 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH40900.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TMEM95 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM95 Gene

Post-translational modifications for TMEM95 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TMEM95 Gene

Domains & Families for TMEM95 Gene

Protein Domains for TMEM95 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM95 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM95: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TMEM95 Gene

Function for TMEM95 Gene

genes like me logo Genes that share phenotypes with TMEM95: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMEM95 Gene

Localization for TMEM95 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM95 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM95 gene
Compartment Confidence
plasma membrane 2
extracellular 2

Gene Ontology (GO) - Cellular Components for TMEM95 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM95: view

Pathways & Interactions for TMEM95 Gene

SuperPathways for TMEM95 Gene

No Data Available

Interacting Proteins for TMEM95 Gene

Gene Ontology (GO) - Biological Process for TMEM95 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM95 Gene

Transcripts for TMEM95 Gene

mRNA/cDNA for TMEM95 Gene

(10) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMEM95 Gene

Transmembrane protein 95:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM95 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b
SP1: -
SP2:

Relevant External Links for TMEM95 Gene

GeneLoc Exon Structure for
TMEM95
ECgene alternative splicing isoforms for
TMEM95

Expression for TMEM95 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TMEM95 Gene

mRNA differential expression in normal tissues according to GTEx for TMEM95 Gene

This gene is overexpressed in Testis (x48.9).

Protein differential expression in normal tissues from HIPED for TMEM95 Gene

This gene is overexpressed in Lung (34.5), Pancreas (24.4), and Liver, secretome (10.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM95 Gene



Protein tissue co-expression partners for TMEM95 Gene

NURSA nuclear receptor signaling pathways regulating expression of TMEM95 Gene:

TMEM95

SOURCE GeneReport for Unigene cluster for TMEM95 Gene:

Hs.259432
genes like me logo Genes that share expression patterns with TMEM95: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for TMEM95 Gene

Orthologs for TMEM95 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TMEM95 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM95 34 35
  • 99.64 (n)
dog
(Canis familiaris)
Mammalia TMEM95 34
  • 80.11 (n)
cow
(Bos Taurus)
Mammalia TMEM95 34
  • 79.07 (n)
rat
(Rattus norvegicus)
Mammalia Tmem95 34
  • 78.32 (n)
mouse
(Mus musculus)
Mammalia Tmem95 34 16 35
  • 77.39 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM95 35
  • 62 (a)
OneToOne
Species where no ortholog for TMEM95 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TMEM95 Gene

ENSEMBL:
Gene Tree for TMEM95 (if available)
TreeFam:
Gene Tree for TMEM95 (if available)

Paralogs for TMEM95 Gene

No data available for Paralogs for TMEM95 Gene

Variants for TMEM95 Gene

Sequence variations from dbSNP and Humsavar for TMEM95 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs112093620 -- 7,355,545(+) AACCT(A/G)GGCTG intron-variant
rs112812573 -- 7,353,475(+) GCAGC(C/G/T)GCTGT nc-transcript-variant, upstream-variant-2KB, reference, missense
rs113252080 -- 7,357,211(+) TTGCT(C/G)TTCAT downstream-variant-500B, utr-variant-3-prime
rs113407034 -- 7,356,153(+) GGAGG(C/T)CCGGC intron-variant
rs114065229 -- 7,354,407(+) GCTGA(C/G)TACAG nc-transcript-variant, upstream-variant-2KB, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TMEM95 Gene

Variant ID Type Subtype PubMed ID
esv2422288 CNV deletion 17116639
nsv457659 CNV loss 19166990
nsv574322 CNV loss 21841781
nsv952118 CNV deletion 24416366

Variation tolerance for TMEM95 Gene

Residual Variation Intolerance Score: 80.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.92; 19.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM95 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM95

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM95 Gene

Disorders for TMEM95 Gene

Relevant External Links for TMEM95

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM95

No disorders were found for TMEM95 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM95 Gene

Publications for TMEM95 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4 64
  2. A nonsense mutation in TMEM95 encoding a nondescript transmembrane protein causes idiopathic male subfertility in cattle. (PMID: 24391514) Pausch H. … Fries R. (PLoS Genet. 2014) 3 64
  3. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody M.C. … Nusbaum C. (Nature 2006) 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for TMEM95 Gene

Sources for TMEM95 Gene

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