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TMEM95 Gene

protein-coding   GIFtS: 33
GCID: GC17P007258

Transmembrane Protein 95

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Transmembrane Protein 951 2
UNQ93902

External Ids:    HGNC: 278981   Entrez Gene: 3391682   Ensembl: ENSG000001828967   UniProtKB: Q3KNT93   

Export aliases for TMEM95 gene to outside databases

Previous GC identifers: GC17P007200 GC17P007152


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TMEM95 Gene:
TMEM95 (transmembrane protein 95) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_010718.17  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TMEM95 gene promoter:
         Bach1   Elk-1   RREB-1   NRSF form 1   MyoD   NRSF form 2   E47   MZF-1   Zic3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMEM95 promoter sequence
   Search Chromatin IP Primers for TMEM95

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TMEM95


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.1   Ensembl cytogenetic band:  17p13.1   HGNC cytogenetic band: 17p13.1

TMEM95 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM95 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P007258:  view genomic region     (about GC identifiers)

Start:
7,258,442 bp from pter      End:
7,260,538 bp from pter
Size:
2,097 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TMM95_HUMAN, Q3KNT9 (See protein sequence)
Recommended Name: Transmembrane protein 95 precursor  
Size: 176 amino acids; 19597 Da
Sequence caution: Sequence=AAH40900.1; Type=Erroneous initiation;
Secondary accessions: B7WPI7 Q6UXT3 Q8IW68
Alternative splicing: 3 isoforms:  Q3KNT9-1   Q3KNT9-2   Q3KNT9-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TMEM95: NX_Q3KNT9

Explore proteomics data for TMEM95 at MOPED


See TMEM95 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_937797.1  
ENSEMBL proteins: 
 ENSP00000374632   ENSP00000460828   ENSP00000331466  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:
 IPR027984 TMEM95

Graphical View of Domain Structure for InterPro Entry Q3KNT9

ProtoNet protein and cluster: Q3KNT9


Find genes that share domains with TMEM95           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Animal Models:
   genOway: Develop your customized and physiologically relevant rodent model for TMEM95

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
TMM95_HUMAN, Q3KNT9: Membrane; Single-pass type I membrane protein (Potential)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
extracellular2
plasma membrane2

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0016021integral component of membrane IEA--

Find genes that share ontologies with TMEM95           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TMEM95
Interactions:

    Search GeneGlobe Interaction Network for TMEM95

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
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Browse Tocris compounds for TMEM95 (TMM95)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for TMEM95 gene: 
NM_198154.1  

Unigene Cluster for TMEM95:

Transmembrane protein 95
Hs.259432  [show with all ESTs]
Unigene Representative Sequence: BC040900
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000389982 ENST00000576060 ENST00000330767(uc002ggf.1 uc002ggg.1 uc002ggh.1)

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SwitchGear 3'UTR luciferase reporter plasmidTMEM95 3' UTR sequence
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Additional mRNA sequence: 

AY358218.1 BC040900.1 BC107110.2 

2 DOTS entries:

DT.101978031  DT.440247 

10 AceView cDNA sequences:

AY358218 BE158732 BC040900 NM_198154 BE158849 BE158850 AW663471 BM563032 
AA868533 AA459848 

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for TMEM95    About this scheme

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b
SP1:                                      -                     
SP2:                                                            


ECgene alternative splicing isoforms for TMEM95

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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TMEM95 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
TMEM95 Expression
About this image

TMEM95 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

TMEM95 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.259432
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In Situ
Assay Products:
 

 
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of human and mouse.

Orthologs for TMEM95 gene from Selected species (see all 6)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Tmem951 , 5 transmembrane protein 951, 5 77.39(n)1
65.52(a)1
  11 (42.91 cM)5
1005033611  NM_001195710.11  NP_001182639.11 
 698766845 


ENSEMBL Gene Tree for TMEM95 (if available)
TreeFam Gene Tree for TMEM95 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for TMEM95 (see all 94)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 17 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs98955951,2
C,F,H--7258861(+) CAGAAC/ACTGGG 1 -- int118Minor allele frequency- A:0.11NS EA NA CSA WA 2326
rs3754951401,2
C--7258979(+) GGAAAC/GAGTGA 1 -- int10--------
rs2013639181,2
C--7259005(+) GGATAA/CCAAGG 1 -- int10--------
rs1885721581,2
--7259018(+) AGGGAC/TGGGTG 1 -- int10--------
rs1480393031,2
C--7259070(+) CAGGAC/GGGCTG 1 -- int10--------
rs65030161,2
C,F,A,H--7259073(+) GAGGGC/TTGATC 1 -- int110Minor allele frequency- T:0.49NA CSA WA EA 373
rs1448253001,2
C--7259083(+) AGGGA-/C/GGGGGC 1 -- int10--------
rs1931595151,2
--7259087(+) GAGGGA/GCTGCG 1 -- int10--------
rs1408100511,2
C--7259118(+) CCCGTC/TGAGGC 1 -- int10--------
rs1838493031,2
C--7259122(+) TCGAGA/GCCCAG 1 -- int10--------

HapMap Linkage Disequilibrium report for TMEM95 (7258442 - 7260538 bp)

Structural Variations
     Database of Genomic Variants (DGV) 5 variations for TMEM95:    About this table    
Variant IDTypeSubtypePubMed ID
esv2422288CNV Deletion17116639
dgv3053n71CNV Loss21882294
nsv907642CNV Loss21882294
nsv457659CNV Loss19166990
nsv907643CNV Loss21882294

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for TMEM95 gene integrated from 10 sources:
(articles sorted by number of sources associating them with TMEM95)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2, 3 Clark H.F.... Gray A.M. (Genome Res. 2003)
  2. A nonsense mutation in TMEM95 encoding a nondescript transmembrane protein causes idiopathic male subfertility in cattle. (PubMed id 24391514)1 Pausch H....Fries R. (PLoS Genet. 2014)
  3. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)2 Zody M.C.... Nusbaum C. (Nature 2006)
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 339168 HGNC: 27898 AceView: LOC339168 Ensembl:ENSG00000182896 euGenes: HUgn339168
ECgene: TMEM95 H-InvDB: TMEM95

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for TMEM95 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for TMEM95 gene:
Search GeneIP for patents involving TMEM95

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes      Disease genes      TMEM95 gene at Home site.
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