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Aliases for TMEM94 Gene

Aliases for TMEM94 Gene

  • Transmembrane Protein 94 2 3 5
  • KIAA0195 2 3 4

External Ids for TMEM94 Gene

Previous HGNC Symbols for TMEM94 Gene

  • KIAA0195

Summaries for TMEM94 Gene

GeneCards Summary for TMEM94 Gene

TMEM94 (Transmembrane Protein 94) is a Protein Coding gene.

Additional gene information for TMEM94 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM94 Gene

Genomics for TMEM94 Gene

Regulatory Elements for TMEM94 Gene

Enhancers for TMEM94 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17H075455 2 FANTOM5 Ensembl ENCODE dbSUPER 21.3 +17.1 17084 6 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 ZBTB7B YY1 SLC30A9 TMEM94 NUP85 RECQL5 CDK3 ENSG00000266980 UNK SRP68 LLGL2 CDR2L SLC25A19
GH17H075486 1.3 Ensembl ENCODE dbSUPER 29.1 +46.4 46377 2 HDAC1 HDGF CTCF MAX RAD21 CTBP1 POLR2A FOXK2 EED ETV6 TMEM94 LLGL2 TSEN54 CASKIN2 NUP85 MIR6785
GH17H075507 2 FANTOM5 Ensembl ENCODE dbSUPER 18.8 +72.4 72390 11 MLX ZFP64 DMAP1 SLC30A9 ZNF143 SP3 NFYC SSRP1 ZNF610 ZNF585B ENSG00000267342 ENSG00000266980 NUP85 NT5C TSEN54 LLGL2 NAT9 EXOC7 UNK TMEM94
GH17H075530 1.2 Ensembl ENCODE dbSUPER 25.5 +90.5 90522 2 TBP SCRT1 HDGF USF2 ZIC2 OSR2 MTA3 POLR2A ZBTB33 CHD2 TMEM94 MYO15B LLGL2 TSEN54 GC17P075560
GH17H075537 1.2 Ensembl ENCODE dbSUPER 23.3 +99.7 99656 6 ESRRA KLF1 PPARG RARA ZFHX2 ZGPAT HNF1A ZBTB48 ZSCAN5C BCL6 TMEM94 TSEN54 LLGL2 CASKIN2 CDK3 GC17P075560
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM94 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM94 Gene

Chromosome:
17
Start:
75,441,159 bp from pter
End:
75,500,452 bp from pter
Size:
59,294 bases
Orientation:
Plus strand

Genomic View for TMEM94 Gene

Genes around TMEM94 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM94 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM94 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM94 Gene

Proteins for TMEM94 Gene

  • Protein details for TMEM94 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q12767-TMM94_HUMAN
    Recommended name:
    Transmembrane protein 94
    Protein Accession:
    Q12767
    Secondary Accessions:
    • O75536
    • Q86XF1

    Protein attributes for TMEM94 Gene

    Size:
    1356 amino acids
    Molecular mass:
    151151 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA12108.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TMEM94 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM94 Gene

Post-translational modifications for TMEM94 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TMEM94 Gene

Domains & Families for TMEM94 Gene

Gene Families for TMEM94 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for TMEM94 Gene

Suggested Antigen Peptide Sequences for TMEM94 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM94: view

No data available for UniProtKB/Swiss-Prot for TMEM94 Gene

Function for TMEM94 Gene

Phenotypes From GWAS Catalog for TMEM94 Gene

genes like me logo Genes that share phenotypes with TMEM94: view

Animal Models for TMEM94 Gene

MGI Knock Outs for TMEM94:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TMEM94
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TMEM94 Gene

Localization for TMEM94 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM94 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM94 gene
Compartment Confidence
plasma membrane 3
nucleus 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Nuclear bodies (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TMEM94 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM94: view

Pathways & Interactions for TMEM94 Gene

SuperPathways for TMEM94 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMEM94 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM94 Gene

Drugs & Compounds for TMEM94 Gene

No Compound Related Data Available

Transcripts for TMEM94 Gene

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TMEM94
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM94 Gene

No ASD Table

Relevant External Links for TMEM94 Gene

GeneLoc Exon Structure for
TMEM94
ECgene alternative splicing isoforms for
TMEM94

Expression for TMEM94 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of TMEM94 Gene:

TMEM94

mRNA Expression by UniProt/SwissProt for TMEM94 Gene:

Q12767-TMM94_HUMAN
Tissue specificity: Expressed ubiquitously.

Evidence on tissue expression from TISSUES for TMEM94 Gene

  • Nervous system(4.9)
  • Bone marrow(4.2)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with TMEM94: view

Primer Products

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM94 Gene

Orthologs for TMEM94 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM94 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIAA0195 34 33
  • 99.63 (n)
OneToOne
dog
(Canis familiaris)
Mammalia KIAA0195 34 33
  • 90.81 (n)
OneToOne
cow
(Bos Taurus)
Mammalia KIAA0195 34 33
  • 90.36 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KIAA0195 34
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 2310067B10Rik 34 33
  • 89.28 (n)
OneToOne
Tmem94 16
platypus
(Ornithorhynchus anatinus)
Mammalia KIAA0195 34
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves KIAA0195 34 33
  • 75.98 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KIAA0195 34
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kiaa0195 33
  • 70.58 (n)
zebrafish
(Danio rerio)
Actinopterygii si:dkeyp-67e6.4 34
  • 68 (a)
OneToOne
LOC795408 33
  • 67.47 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000576 33
  • 50.34 (n)
fruit fly
(Drosophila melanogaster)
Insecta l(2)k05819 33 34
  • 48.98 (n)
worm
(Caenorhabditis elegans)
Secernentea D1007.15 33 34
  • 41.03 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 28 (a)
OneToMany
-- 34
  • 23 (a)
OneToMany
Species where no ortholog for TMEM94 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMEM94 Gene

ENSEMBL:
Gene Tree for TMEM94 (if available)
TreeFam:
Gene Tree for TMEM94 (if available)

Paralogs for TMEM94 Gene

No data available for Paralogs for TMEM94 Gene

Variants for TMEM94 Gene

Sequence variations from dbSNP and Humsavar for TMEM94 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs193921068 Uncertain significance 75,489,661(+) GCTCC(A/G)GGCAA nc-transcript-variant, reference, missense
rs1000015361 -- 75,499,498(+) AGCCC(C/T)GGGGC utr-variant-3-prime
rs1000026165 -- 75,451,597(+) ACTCT(C/G)CCACC intron-variant
rs1000076460 -- 75,441,549(+) CAGGT(A/G)CGCGA intron-variant
rs1000128277 -- 75,457,889(+) AGTTC(C/T)CTGAC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TMEM94 Gene

Variant ID Type Subtype PubMed ID
esv3582912 CNV loss 25503493
esv3641265 CNV gain 21293372
nsv1138579 CNV deletion 24896259
nsv470603 CNV loss 18288195
nsv476677 CNV novel sequence insertion 20440878
nsv516133 CNV loss 19592680
nsv576027 CNV gain 21841781
nsv833541 CNV loss 17160897
nsv833542 CNV loss 17160897
nsv952368 CNV deletion 24416366

Variation tolerance for TMEM94 Gene

Residual Variation Intolerance Score: 5.42% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.17; 39.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM94 Gene

Human Gene Mutation Database (HGMD)
TMEM94
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM94

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM94 Gene

Disorders for TMEM94 Gene

Relevant External Links for TMEM94

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM94
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM94

No disorders were found for TMEM94 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM94 Gene

Publications for TMEM94 Gene

  1. Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 8724849) Nagase T … Nomura N (DNA research : an international journal for rapid publication of reports on genes and genomes 1996) 2 3 4 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  4. Cold-inducible RBM3 inhibits PERK phosphorylation through cooperation with NF90 to protect cells from endoplasmic reticulum stress. (PMID: 26472337) Zhu X … Wellmann S (FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2016) 3 60
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60

Products for TMEM94 Gene

Sources for TMEM94 Gene

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