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Aliases for TMEM94 Gene

Aliases for TMEM94 Gene

  • Transmembrane Protein 94 2 3 5
  • KIAA0195 2 3 4

External Ids for TMEM94 Gene

Previous HGNC Symbols for TMEM94 Gene

  • KIAA0195

Summaries for TMEM94 Gene

GeneCards Summary for TMEM94 Gene

TMEM94 (Transmembrane Protein 94) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM94 Gene

Genomics for TMEM94 Gene

Regulatory Elements for TMEM94 Gene

Enhancers for TMEM94 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F075480 0.2 Ensembl 12.8 +40.2 40242 1.2 KLF1 ZMYM3 ZIC2 ZFHX2 GLIS1 ZNF600 SP7 EGR2 TSEN54 TMEM94 MIR6785 CASKIN2 LLGL2 HN1 NUP85
GH17F075485 0.6 Ensembl ENCODE 12.3 +45.9 45942 3.0 HDGF CTCF HDAC1 CBX3 MAX KLF17 RAD21 ZBTB40 ZFHX2 FOXK2 LLGL2 TSEN54 CASKIN2 MIR6785 TMEM94 NUP85
GH17F075396 0.7 ENCODE 11.5 -44.2 -44185 0.2 PKNOX1 JUNB PRDM1 TMEM94 MIR6785 ATP5H KCTD2 ENSG00000265342 GRB2
GH17F075293 1.2 FANTOM5 ENCODE 11.4 -144.7 -144749 5.4 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 YBX1 YY1 SLC30A9 GRB2 H3F3B NUP85 MIR6785 TMEM94 LLGL2 ENSG00000267342 UNK SAP30BP MYO15B
GH17F075410 1 Ensembl ENCODE 11.2 -29.1 -29069 2.2 HDGF PKNOX1 WRNIP1 ARID4B YBX1 ZNF48 ZNF2 ZNF121 SLC30A9 ZNF143 NUP85 ENSG00000266980 LOC101928343 LLGL2 MIR6785 TMEM94 NT5C MIF4GD ENSG00000267342 SPHK1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around TMEM94 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM94 Gene

Chromosome:
17
Start:
75,441,159 bp from pter
End:
75,500,452 bp from pter
Size:
59,294 bases
Orientation:
Plus strand

Genomic View for TMEM94 Gene

Genes around TMEM94 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM94 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM94 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM94 Gene

Proteins for TMEM94 Gene

  • Protein details for TMEM94 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q12767-TMM94_HUMAN
    Recommended name:
    Transmembrane protein 94
    Protein Accession:
    Q12767
    Secondary Accessions:
    • O75536
    • Q86XF1

    Protein attributes for TMEM94 Gene

    Size:
    1356 amino acids
    Molecular mass:
    151151 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA12108.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TMEM94 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM94 Gene

Post-translational modifications for TMEM94 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TMEM94 Gene

Domains & Families for TMEM94 Gene

Protein Domains for TMEM94 Gene

Suggested Antigen Peptide Sequences for TMEM94 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM94: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TMEM94 Gene

Function for TMEM94 Gene

genes like me logo Genes that share phenotypes with TMEM94: view

Animal Models for TMEM94 Gene

MGI Knock Outs for TMEM94:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TMEM94 Gene

Localization for TMEM94 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM94 Gene

Membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for TMEM94 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM94: view

No data available for Subcellular locations from COMPARTMENTS for TMEM94 Gene

Pathways & Interactions for TMEM94 Gene

SuperPathways for TMEM94 Gene

No Data Available

Interacting Proteins for TMEM94 Gene

Gene Ontology (GO) - Biological Process for TMEM94 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM94 Gene

Transcripts for TMEM94 Gene

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM94 Gene

No ASD Table

Relevant External Links for TMEM94 Gene

GeneLoc Exon Structure for
TMEM94
ECgene alternative splicing isoforms for
TMEM94

Expression for TMEM94 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of TMEM94 Gene:

TMEM94

mRNA Expression by UniProt/SwissProt for TMEM94 Gene:

Q12767-TMM94_HUMAN
Tissue specificity: Expressed ubiquitously.
genes like me logo Genes that share expression patterns with TMEM94: view

Primer Products

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for TMEM94 Gene

Orthologs for TMEM94 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM94 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIAA0195 34 35
  • 99.63 (n)
dog
(Canis familiaris)
Mammalia KIAA0195 34 35
  • 90.81 (n)
cow
(Bos Taurus)
Mammalia KIAA0195 34 35
  • 90.36 (n)
oppossum
(Monodelphis domestica)
Mammalia KIAA0195 35
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 2310067B10Rik 34 35
  • 89.28 (n)
Tmem94 16
platypus
(Ornithorhynchus anatinus)
Mammalia KIAA0195 35
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves KIAA0195 34 35
  • 75.98 (n)
lizard
(Anolis carolinensis)
Reptilia KIAA0195 35
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kiaa0195 34
  • 70.58 (n)
zebrafish
(Danio rerio)
Actinopterygii si:dkeyp-67e6.4 35
  • 68 (a)
OneToOne
LOC795408 34
  • 67.47 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000576 34
  • 50.34 (n)
fruit fly
(Drosophila melanogaster)
Insecta l(2)k05819 34 35
  • 48.98 (n)
worm
(Caenorhabditis elegans)
Secernentea D1007.15 34 35
  • 41.03 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 28 (a)
OneToMany
-- 35
  • 23 (a)
OneToMany
Species where no ortholog for TMEM94 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMEM94 Gene

ENSEMBL:
Gene Tree for TMEM94 (if available)
TreeFam:
Gene Tree for TMEM94 (if available)

Paralogs for TMEM94 Gene

No data available for Paralogs for TMEM94 Gene

Variants for TMEM94 Gene

Sequence variations from dbSNP and Humsavar for TMEM94 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs193921068 Uncertain significance 75,489,661(+) GCTCC(A/G)GGCAA nc-transcript-variant, reference, missense
rs10561730 -- 75,475,732(+) AGCCT(-/CA)TGGGC intron-variant, upstream-variant-2KB
rs10588689 -- 75,455,527(+) AACCA(-/ACCA)TGTGA intron-variant, upstream-variant-2KB
rs10591408 -- 75,464,498(+) CAAAC(-/AAAC)CTGGG intron-variant
rs10591409 -- 75,464,622(+) TTCTT(-/T)CCTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM94 Gene

Variant ID Type Subtype PubMed ID
esv3582912 CNV loss 25503493
esv3641265 CNV gain 21293372
nsv1138579 CNV deletion 24896259
nsv470603 CNV loss 18288195
nsv476677 CNV novel sequence insertion 20440878
nsv516133 CNV loss 19592680
nsv576027 CNV gain 21841781
nsv833541 CNV loss 17160897
nsv833542 CNV loss 17160897
nsv952368 CNV deletion 24416366

Variation tolerance for TMEM94 Gene

Residual Variation Intolerance Score: 5.42% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.17; 39.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM94 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM94

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM94 Gene

Disorders for TMEM94 Gene

Relevant External Links for TMEM94

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM94
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM94

No disorders were found for TMEM94 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM94 Gene

Publications for TMEM94 Gene

  1. Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 8724849) Nagase T. … Nomura N. (DNA Res. 1996) 2 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy. (PMID: 25852190) So J. … Colwill K. (Sci Signal 2015) 3 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4 64

Products for TMEM94 Gene

Sources for TMEM94 Gene

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