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Aliases for TMEM92 Gene

Aliases for TMEM92 Gene

  • Transmembrane Protein 92 2 3

External Ids for TMEM92 Gene

Summaries for TMEM92 Gene

GeneCards Summary for TMEM92 Gene

TMEM92 is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM92 Gene

Genomics for TMEM92 Gene

Genomic Location for TMEM92 Gene

Start:
50,271,406 bp from pter
End:
50,281,485 bp from pter
Size:
10,080 bases
Orientation:
Plus strand

Genomic View for TMEM92 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM92 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM92 Gene

Regulatory Elements for TMEM92 Gene

Proteins for TMEM92 Gene

  • Protein details for TMEM92 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UXU6-TMM92_HUMAN
    Recommended name:
    Transmembrane protein 92
    Protein Accession:
    Q6UXU6
    Secondary Accessions:
    • Q8NBF0

    Protein attributes for TMEM92 Gene

    Size:
    159 amino acids
    Molecular mass:
    17229 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM92 Gene

Proteomics data for TMEM92 Gene at MOPED

Post-translational modifications for TMEM92 Gene

No Post-translational modifications

Other Protein References for TMEM92 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM92 Gene

Domains for TMEM92 Gene

Protein Domains for TMEM92 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for TMEM92 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM92: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TMEM92 Gene

Function for TMEM92 Gene

Phenotypes for TMEM92 Gene

GenomeRNAi human phenotypes for TMEM92:
genes like me logo Genes that share phenotypes with TMEM92: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TMEM92 Gene

Localization for TMEM92 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM92 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM92 Gene COMPARTMENTS Subcellular localization image for TMEM92 gene
Compartment Confidence
plasma membrane 3
extracellular 1

Gene Ontology (GO) - Cellular Components for TMEM92 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM92: view

Pathways for TMEM92 Gene

SuperPathways for TMEM92 Gene

No Data Available

Interacting Proteins for TMEM92 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000300433%0d%0a9606.ENSP00000358081%0d%0a
Selected Interacting proteins: ENSP00000300433 for TMEM92 Gene via STRING

Symbol External ID(s) Details
BAG3

Gene Ontology (GO) - Biological Process for TMEM92 Gene

None

No data available for Pathways by source for TMEM92 Gene

Transcripts for TMEM92 Gene

mRNA/cDNA for TMEM92 Gene

Unigene Clusters for TMEM92 Gene

Transmembrane protein 92:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM92 Gene

No ASD Table

Relevant External Links for TMEM92 Gene

GeneLoc Exon Structure for
TMEM92
ECgene alternative splicing isoforms for
TMEM92

Expression for TMEM92 Gene

mRNA expression in normal human tissues for TMEM92 Gene

mRNA differential expression in normal tissues according to GTEx for TMEM92 Gene

This gene is overexpressed in Stomach (13.6), Small Intestine - Terminal Ileum (9.8), and Liver (6.6).

SOURCE GeneReport for Unigene cluster for TMEM92 Gene Hs.224630

genes like me logo Genes that share expressions with TMEM92: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein expression and mRNA Expression by UniProt/SwissProt for TMEM92 Gene

Orthologs for TMEM92 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TMEM92 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC747062 35
  • 96.99 (n)
  • 95.14 (a)
TMEM92 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM92 36
  • 58 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM92 35
  • 76.65 (n)
  • 66.24 (a)
TMEM92 36
  • 58 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem92 36
  • 41 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMEM92 36
  • 45 (a)
OneToOne
Species with no ortholog for TMEM92:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TMEM92 Gene

ENSEMBL:
Gene Tree for TMEM92 (if available)
TreeFam:
Gene Tree for TMEM92 (if available)

Paralogs for TMEM92 Gene

Pseudogenes.org Pseudogenes for TMEM92 Gene

genes like me logo Genes that share paralogs with TMEM92: view

No data available for Paralogs for TMEM92 Gene

Variants for TMEM92 Gene

Sequence variations from dbSNP and Humsavar for TMEM92 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs1881143 -- 50,277,222(-) TCTTT(C/T)TCTTC intron-variant
rs1881144 -- 50,277,059(-) TGTAC(C/T)AGGTC intron-variant
rs1969512 -- 50,280,055(-) ACCCA(A/C)ACAAG utr-variant-3-prime
rs1969513 -- 50,279,939(-) GACTG(G/T)CCTCC utr-variant-3-prime
rs2141280 -- 50,271,889(-) ctaat(A/T)ttttg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM92 Gene

Variant ID Type Subtype PubMed ID
nsv833475 CNV Loss 17160897
nsv509661 CNV Insertion 20534489

Relevant External Links for TMEM92 Gene

HapMap Linkage Disequilibrium report
TMEM92
Human Gene Mutation Database (HGMD)
TMEM92

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM92 Gene

Disorders for TMEM92 Gene

Relevant External Links for TMEM92

Genetic Association Database (GAD)
TMEM92
Human Genome Epidemiology (HuGE) Navigator
TMEM92
genes like me logo Genes that share disorders with TMEM92: view

No data available for UniProtKB/Swiss-Prot for TMEM92 Gene

Publications for TMEM92 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging. (PMID: 19834535) Wheeler H.E. … Kim S.K. (PLoS Genet. 2009) 3 48
  5. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PMID: 23824909) Chen Y. … Ge F. (Mol. Cell Proteomics 2013) 3

Products for TMEM92 Gene

Sources for TMEM92 Gene

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