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Aliases for TMEM91 Gene

Aliases for TMEM91 Gene

  • Transmembrane Protein 91 2 3 5
  • Interferon Induced Transmembrane Protein Domain Containing 6 2 3
  • Dispanin Subfamily C Member 3 3 4
  • DSPC3 3 4
  • IFITMD6 3

External Ids for TMEM91 Gene

Previous GeneCards Identifiers for TMEM91 Gene

  • GC19U900569
  • GC19P046549
  • GC19P041869
  • GC19P038301
  • GC19P041856

Summaries for TMEM91 Gene

GeneCards Summary for TMEM91 Gene

TMEM91 (Transmembrane Protein 91) is a Protein Coding gene. An important paralog of this gene is SYNDIG1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM91 Gene

Genomics for TMEM91 Gene

Regulatory Elements for TMEM91 Gene

Promoters for TMEM91 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TMEM91 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM91 Gene

Chromosome:
19
Start:
41,350,911 bp from pter
End:
41,384,083 bp from pter
Size:
33,173 bases
Orientation:
Plus strand

Genomic View for TMEM91 Gene

Genes around TMEM91 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM91 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM91 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM91 Gene

Proteins for TMEM91 Gene

  • Protein details for TMEM91 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZNR0-TMM91_HUMAN
    Recommended name:
    Transmembrane protein 91
    Protein Accession:
    Q6ZNR0
    Secondary Accessions:
    • C9J9D1
    • C9JZ62
    • C9K046
    • Q6P434

    Protein attributes for TMEM91 Gene

    Size:
    172 amino acids
    Molecular mass:
    18162 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BM931402; Type=Frameshift; Positions=122; Evidence={ECO:0000305};

    Alternative splice isoforms for TMEM91 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM91 Gene

Proteomics data for TMEM91 Gene at MOPED

Post-translational modifications for TMEM91 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TMEM91 Gene

Domains & Families for TMEM91 Gene

Protein Domains for TMEM91 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM91 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6ZNR0

UniProtKB/Swiss-Prot:

TMM91_HUMAN :
  • Belongs to the CD225/Dispanin family.
Family:
  • Belongs to the CD225/Dispanin family.
genes like me logo Genes that share domains with TMEM91: view

No data available for Gene Families for TMEM91 Gene

Function for TMEM91 Gene

genes like me logo Genes that share phenotypes with TMEM91: view

Animal Model Products

miRNA for TMEM91 Gene

miRTarBase miRNAs that target TMEM91

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM91 Gene

Localization for TMEM91 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM91 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM91 Gene COMPARTMENTS Subcellular localization image for TMEM91 gene
Compartment Confidence
plasma membrane 3
extracellular 2

No data available for Gene Ontology (GO) - Cellular Components for TMEM91 Gene

Pathways & Interactions for TMEM91 Gene

SuperPathways for TMEM91 Gene

No Data Available

Interacting Proteins for TMEM91 Gene

Gene Ontology (GO) - Biological Process for TMEM91 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0009607 response to biotic stimulus IEA --
genes like me logo Genes that share ontologies with TMEM91: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM91 Gene

Drugs & Compounds for TMEM91 Gene

No Compound Related Data Available

Transcripts for TMEM91 Gene

mRNA/cDNA for TMEM91 Gene

(6) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(14) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMEM91 Gene

Transmembrane protein 91:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM91 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c
SP1: - -
SP2: - -
SP3: -
SP4: -
SP5:

Relevant External Links for TMEM91 Gene

GeneLoc Exon Structure for
TMEM91
ECgene alternative splicing isoforms for
TMEM91

Expression for TMEM91 Gene

mRNA expression in normal human tissues for TMEM91 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM91 Gene

This gene is overexpressed in Whole Blood (x8.0).

Protein differential expression in normal tissues from HIPED for TMEM91 Gene

This gene is overexpressed in Lung (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM91 Gene



SOURCE GeneReport for Unigene cluster for TMEM91 Gene Hs.709417

genes like me logo Genes that share expression patterns with TMEM91: view

Protein tissue co-expression partners for TMEM91 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for TMEM91 Gene

Orthologs for TMEM91 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM91 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TMEM91 35
  • 84.12 (n)
  • 84.71 (a)
TMEM91 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM91 35
  • 85.08 (n)
  • 85.47 (a)
mouse
(Mus musculus)
Mammalia Tmem91 35
  • 79.26 (n)
  • 78.49 (a)
Tmem91 16
Tmem91 36
  • 78 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TMEM91 35
  • 99.42 (n)
  • 99.42 (a)
TMEM91 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem91 35
  • 78.49 (n)
  • 77.33 (a)
lizard
(Anolis carolinensis)
Reptilia TMEM91 36
  • 30 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii tmem91 36
  • 30 (a)
OneToOne
Species with no ortholog for TMEM91:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM91 Gene

ENSEMBL:
Gene Tree for TMEM91 (if available)
TreeFam:
Gene Tree for TMEM91 (if available)

Paralogs for TMEM91 Gene

Paralogs for TMEM91 Gene

(2) SIMAP similar genes for TMEM91 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with TMEM91: view

Variants for TMEM91 Gene

Sequence variations from dbSNP and Humsavar for TMEM91 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs12602 -- 41,383,843(-) TAGGC(A/G)GCCAG intron-variant, reference, synonymous-codon, utr-variant-3-prime
rs1058581 -- 41,374,276(+) CCAGT(C/T)TGGTG intron-variant
rs1529717 -- 41,377,293(-) ACAAC(C/T)CTACT intron-variant, utr-variant-5-prime
rs1077856 -- 41,379,316(-) taaaa(A/G)taaag intron-variant
rs2015924 -- 41,378,825(+) GTGTG(A/T)GAGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM91 Gene

Variant ID Type Subtype PubMed ID
nsv521311 CNV Gain 19592680
esv2587471 CNV Insertion 19546169
esv996035 CNV Deletion 20482838

Variation tolerance for TMEM91 Gene

Residual Variation Intolerance Score: 64.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.21; 39.87% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM91 Gene

HapMap Linkage Disequilibrium report
TMEM91

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM91 Gene

Disorders for TMEM91 Gene

Relevant External Links for TMEM91

Genetic Association Database (GAD)
TMEM91
Human Genome Epidemiology (HuGE) Navigator
TMEM91
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM91

No disorders were found for TMEM91 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM91 Gene

Publications for TMEM91 Gene

  1. The dispanins: a novel gene family of ancient origin that contains 14 human members. (PMID: 22363774) Sallman Almen M. … Schioth H.B. (PLoS ONE 2012) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3
  4. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PMID: 19913121) Talmud P.J. … . (Am. J. Hum. Genet. 2009) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for TMEM91 Gene

Sources for TMEM91 Gene

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