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Aliases for TMEM9 Gene

Aliases for TMEM9 Gene

  • Transmembrane Protein 9 2 3 5
  • Dermal Papilla-Derived Protein 4 3 4
  • TMEM9A 3
  • DERM4 3
  • DERP4 4

External Ids for TMEM9 Gene

Previous GeneCards Identifiers for TMEM9 Gene

  • GC00U991238
  • GC01M196562
  • GC01M197570
  • GC01M198392
  • GC01M197835
  • GC01M199370
  • GC01M172270

Summaries for TMEM9 Gene

GeneCards Summary for TMEM9 Gene

TMEM9 (Transmembrane Protein 9) is a Protein Coding gene. Diseases associated with TMEM9 include phacogenic glaucoma. An important paralog of this gene is TMEM9B.

UniProtKB/Swiss-Prot for TMEM9 Gene

  • May be involved in intracellular transport.

Gene Wiki entry for TMEM9 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM9 Gene

Genomics for TMEM9 Gene

Regulatory Elements for TMEM9 Gene

Enhancers for TMEM9 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TMEM9 on UCSC Golden Path with GeneCards custom track

Promoters for TMEM9 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TMEM9 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM9 Gene

Chromosome:
1
Start:
201,134,771 bp from pter
End:
201,171,582 bp from pter
Size:
36,812 bases
Orientation:
Minus strand

Genomic View for TMEM9 Gene

Genes around TMEM9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM9 Gene

Proteins for TMEM9 Gene

  • Protein details for TMEM9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P0T7-TMEM9_HUMAN
    Recommended name:
    Transmembrane protein 9
    Protein Accession:
    Q9P0T7
    Secondary Accessions:
    • B1ALM6
    • Q96NQ9
    • Q9BQF5

    Protein attributes for TMEM9 Gene

    Size:
    183 amino acids
    Molecular mass:
    20574 Da
    Quaternary structure:
    • Dimer.

neXtProt entry for TMEM9 Gene

Proteomics data for TMEM9 Gene at MOPED

Post-translational modifications for TMEM9 Gene

No data available for DME Specific Peptides for TMEM9 Gene

Domains & Families for TMEM9 Gene

Protein Domains for TMEM9 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM9 Gene

Graphical View of Domain Structure for InterPro Entry

Q9P0T7

UniProtKB/Swiss-Prot:

TMEM9_HUMAN :
  • Belongs to the TMEM9 family.
Family:
  • Belongs to the TMEM9 family.
genes like me logo Genes that share domains with TMEM9: view

No data available for Gene Families for TMEM9 Gene

Function for TMEM9 Gene

Molecular function for TMEM9 Gene

UniProtKB/Swiss-Prot Function:
May be involved in intracellular transport.
genes like me logo Genes that share phenotypes with TMEM9: view

Animal Model Products

miRNA for TMEM9 Gene

miRTarBase miRNAs that target TMEM9

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM9 Gene

Localization for TMEM9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM9 Gene

Late endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM9 Gene COMPARTMENTS Subcellular localization image for TMEM9 gene
Compartment Confidence
endosome 5
lysosome 5
vacuole 5
extracellular 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for TMEM9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005764 lysosome IDA 12359240
GO:0005765 lysosomal membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM9: view

Pathways & Interactions for TMEM9 Gene

SuperPathways for TMEM9 Gene

No Data Available

Interacting Proteins for TMEM9 Gene

Selected Interacting proteins: Q9P0T7-TMEM9_HUMAN for TMEM9 Gene via I2D

Symbol External ID(s) Details
CLN3
TMEM230

Gene Ontology (GO) - Biological Process for TMEM9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with TMEM9: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM9 Gene

Drugs & Compounds for TMEM9 Gene

No Compound Related Data Available

Transcripts for TMEM9 Gene

Unigene Clusters for TMEM9 Gene

Transmembrane protein 9:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM9 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c · 9d · 9e
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - - -
SP4: - - - -
SP5: - - - - - - - - -
SP6: - - - - -
SP7: - - - - - -
SP8: - -
SP9: - - -
SP10:

Relevant External Links for TMEM9 Gene

GeneLoc Exon Structure for
TMEM9
ECgene alternative splicing isoforms for
TMEM9

Expression for TMEM9 Gene

mRNA expression in normal human tissues for TMEM9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TMEM9 Gene

This gene is overexpressed in Testis (13.0), Frontal cortex (10.5), and Fetal Liver (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM9 Gene



SOURCE GeneReport for Unigene cluster for TMEM9 Gene Hs.181444

mRNA Expression by UniProt/SwissProt for TMEM9 Gene

Q9P0T7-TMEM9_HUMAN
Tissue specificity: Highly expressed in adrenal gland, thyroid gland, testis, ovary and prostate. Moderate expression in trachea, spinal cord, stomach, colon, small intestine and spleen. Low expression in bone marrow, lymph node, thymus and peripheral blood lymphocytes. Expression was detected in hematopoietic cell lines including those of myeloid, erythroid, B- and T-cell origin.
genes like me logo Genes that share expression patterns with TMEM9: view

Protein tissue co-expression partners for TMEM9 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for TMEM9 Gene

Orthologs for TMEM9 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM9 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TMEM9 35
  • 87.48 (n)
  • 93.92 (a)
TMEM9 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM9 35
  • 91.76 (n)
  • 96.15 (a)
-- 36
  • 94 (a)
OneToMany
-- 36
  • 96 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Tmem9 35
  • 90.89 (n)
  • 97.27 (a)
Tmem9 16
Tmem9 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TMEM9 35
  • 95.37 (n)
  • 95.56 (a)
TMEM9 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem9 35
  • 90.16 (n)
  • 98.36 (a)
oppossum
(Monodelphis domestica)
Mammalia TMEM9 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM9 36
  • 96 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM9 35
  • 80.6 (n)
  • 87.01 (a)
TMEM9 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM9 36
  • 67 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii tmem9 35
  • 75.58 (n)
  • 76.74 (a)
wufi33g11 35
tmem9 36
  • 67 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9265 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007259 35
  • 52.81 (n)
  • 38.76 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1161 35
  • 47.07 (n)
  • 33.94 (a)
worm
(Caenorhabditis elegans)
Secernentea R12C12.6 35
  • 46.63 (n)
  • 33.33 (a)
R12C12.6 36
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 33 (a)
OneToMany
Species with no ortholog for TMEM9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TMEM9 Gene

ENSEMBL:
Gene Tree for TMEM9 (if available)
TreeFam:
Gene Tree for TMEM9 (if available)

Paralogs for TMEM9 Gene

Paralogs for TMEM9 Gene

(1) SIMAP similar genes for TMEM9 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with TMEM9: view

Variants for TMEM9 Gene

Sequence variations from dbSNP and Humsavar for TMEM9 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs3813 -- 201,134,949(+) CAACC(A/G)ACCGT nc-transcript-variant, utr-variant-3-prime
rs8158 -- 201,143,853(-) GCATA(C/T)ACTGA nc-transcript-variant, reference, synonymous-codon
rs10649 -- 201,134,866(+) ACAAC(A/G/T)AAGTT nc-transcript-variant, utr-variant-3-prime
rs875495 -- 201,168,372(+) GAGGG(A/G)AATAA intron-variant
rs958288 -- 201,155,335(+) AGGGG(G/T)GGGTG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TMEM9 Gene

Variant ID Type Subtype PubMed ID
nsv428301 CNV Gain 18775914

Variation tolerance for TMEM9 Gene

Residual Variation Intolerance Score: 40.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.34; 7.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM9 Gene

HapMap Linkage Disequilibrium report
TMEM9
Human Gene Mutation Database (HGMD)
TMEM9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM9 Gene

Disorders for TMEM9 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TMEM9 Gene - From: DISEASES

Disorder Aliases PubMed IDs
phacogenic glaucoma
- elite association - COSMIC cancer census association via MalaCards
Search TMEM9 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TMEM9

Genetic Association Database (GAD)
TMEM9
Human Genome Epidemiology (HuGE) Navigator
TMEM9
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM9
genes like me logo Genes that share disorders with TMEM9: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TMEM9 Gene

Publications for TMEM9 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48 67
  2. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  3. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3
  4. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3
  5. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3

Products for TMEM9 Gene

Sources for TMEM9 Gene

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