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Aliases for TMEM9 Gene

Aliases for TMEM9 Gene

  • Transmembrane Protein 9 2 3 5
  • Dermal Papilla-Derived Protein 4 3 4
  • TMEM9A 3 4
  • DERM4 3
  • DERP4 4

External Ids for TMEM9 Gene

Previous GeneCards Identifiers for TMEM9 Gene

  • GC00U991238
  • GC01M196562
  • GC01M197570
  • GC01M198392
  • GC01M197835
  • GC01M199370
  • GC01M172270

Summaries for TMEM9 Gene

GeneCards Summary for TMEM9 Gene

TMEM9 (Transmembrane Protein 9) is a Protein Coding gene. An important paralog of this gene is TMEM9B.

UniProtKB/Swiss-Prot for TMEM9 Gene

  • May be involved in intracellular transport.

Gene Wiki entry for TMEM9 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM9 Gene

Genomics for TMEM9 Gene

Regulatory Elements for TMEM9 Gene

Enhancers for TMEM9 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G201153 1.1 ENCODE 57.4 +17.2 17190 1.7 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZBTB7B YY1 ZNF766 ZNF143 TMEM9 DDX59 IGFN1 ASCL5 CACNA1S ENSG00000229821
GH01G201265 1.7 FANTOM5 Ensembl ENCODE dbSUPER 15.3 -96.3 -96316 4.5 TBP SIN3A RAD21 ZNF366 ZNF207 RCOR1 FOS DEK USF2 CEBPB TMEM9 ENSG00000229821 LAD1 IGFN1 PKP1 ASCL5 RNPEP INAVA GC01P201247
GH01G201126 1.4 Ensembl ENCODE dbSUPER 9.9 +43.9 43929 2.2 FOXA2 PKNOX1 KLF17 RAD21 RARA SCRT2 FOS EGR2 CEBPB ZNF623 ASCL5 TMEM9
GH01G201346 1 ENCODE dbSUPER 10.2 -175.0 -174960 0.9 GTF2F1 CTCF PKNOX1 ZSCAN4 TEAD4 SIN3A RAD21 TEAD3 CTBP1 GATA3 PKP1 TNNT2 LAD1 ENSG00000229821 IGFN1 TMEM9 GC01M201335 LOC101929326
GH01G201347 0.9 ENCODE dbSUPER 10.2 -176.5 -176489 1.2 SCRT1 CTCF ZNF654 MAX ZBTB7B RAD21 ZFHX2 CTBP1 POLR2A PATZ1 TNNT2 LAD1 PKP1 ENSG00000229821 IGFN1 TMEM9 LOC101929326 GC01M201335
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM9 on UCSC Golden Path with GeneCards custom track

Promoters for TMEM9 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000018046 482 1001 MLX CREB3L1 FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21

Genomic Location for TMEM9 Gene

Chromosome:
1
Start:
201,134,771 bp from pter
End:
201,171,582 bp from pter
Size:
36,812 bases
Orientation:
Minus strand

Genomic View for TMEM9 Gene

Genes around TMEM9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM9 Gene

Proteins for TMEM9 Gene

  • Protein details for TMEM9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P0T7-TMEM9_HUMAN
    Recommended name:
    Transmembrane protein 9
    Protein Accession:
    Q9P0T7
    Secondary Accessions:
    • B1ALM6
    • Q96NQ9
    • Q9BQF5

    Protein attributes for TMEM9 Gene

    Size:
    183 amino acids
    Molecular mass:
    20574 Da
    Quaternary structure:
    • Dimer.

neXtProt entry for TMEM9 Gene

Post-translational modifications for TMEM9 Gene

No data available for DME Specific Peptides for TMEM9 Gene

Domains & Families for TMEM9 Gene

Protein Domains for TMEM9 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM9 Gene

Graphical View of Domain Structure for InterPro Entry

Q9P0T7

UniProtKB/Swiss-Prot:

TMEM9_HUMAN :
  • Belongs to the TMEM9 family.
Family:
  • Belongs to the TMEM9 family.
genes like me logo Genes that share domains with TMEM9: view

No data available for Gene Families for TMEM9 Gene

Function for TMEM9 Gene

Molecular function for TMEM9 Gene

UniProtKB/Swiss-Prot Function:
May be involved in intracellular transport.

Gene Ontology (GO) - Molecular Function for TMEM9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with TMEM9: view
genes like me logo Genes that share phenotypes with TMEM9: view

Animal Model Products

CRISPR Products

miRNA for TMEM9 Gene

miRTarBase miRNAs that target TMEM9

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM9 Gene

Localization for TMEM9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM9 Gene

Late endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM9 gene
Compartment Confidence
lysosome 5
endosome 5
plasma membrane 2
extracellular 2

Gene Ontology (GO) - Cellular Components for TMEM9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005764 lysosome IEA,IDA 12359240
GO:0005765 lysosomal membrane IEA --
GO:0005768 endosome IEA --
GO:0005770 late endosome IDA 12359240
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with TMEM9: view

Pathways & Interactions for TMEM9 Gene

SuperPathways for TMEM9 Gene

No Data Available

Interacting Proteins for TMEM9 Gene

Gene Ontology (GO) - Biological Process for TMEM9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with TMEM9: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM9 Gene

Drugs & Compounds for TMEM9 Gene

No Compound Related Data Available

Transcripts for TMEM9 Gene

Unigene Clusters for TMEM9 Gene

Transmembrane protein 9:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM9 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c · 9d · 9e
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - - -
SP4: - - - -
SP5: - - - - - - - - -
SP6: - - - - -
SP7: - - - - - -
SP8: - -
SP9: - - -
SP10:

Relevant External Links for TMEM9 Gene

GeneLoc Exon Structure for
TMEM9
ECgene alternative splicing isoforms for
TMEM9

Expression for TMEM9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TMEM9 Gene

This gene is overexpressed in Testis (13.0), Frontal cortex (10.5), and Fetal Liver (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM9 Gene



Protein tissue co-expression partners for TMEM9 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TMEM9 Gene:

TMEM9

SOURCE GeneReport for Unigene cluster for TMEM9 Gene:

Hs.181444

mRNA Expression by UniProt/SwissProt for TMEM9 Gene:

Q9P0T7-TMEM9_HUMAN
Tissue specificity: Highly expressed in adrenal gland, thyroid gland, testis, ovary and prostate. Moderate expression in trachea, spinal cord, stomach, colon, small intestine and spleen. Low expression in bone marrow, lymph node, thymus and peripheral blood lymphocytes. Expression was detected in hematopoietic cell lines including those of myeloid, erythroid, B- and T-cell origin.

Evidence on tissue expression from TISSUES for TMEM9 Gene

  • Nervous system(4.9)
  • Kidney(4.4)
  • Skin(4.2)
  • Blood(4.1)
  • Lung(3.2)
  • Eye(2.9)
  • Intestine(2.2)
genes like me logo Genes that share expression patterns with TMEM9: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM9 Gene

Orthologs for TMEM9 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM9 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia -- 35
  • 96 (a)
OneToMany
-- 35
  • 94 (a)
OneToMany
TMEM9 34
  • 91.76 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM9 35
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TMEM9 34 35
  • 95.37 (n)
mouse
(Mus musculus)
Mammalia Tmem9 34 16 35
  • 90.89 (n)
rat
(Rattus norvegicus)
Mammalia Tmem9 34
  • 90.16 (n)
cow
(Bos Taurus)
Mammalia TMEM9 34 35
  • 87.48 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM9 35
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM9 34 35
  • 80.6 (n)
lizard
(Anolis carolinensis)
Reptilia TMEM9 35
  • 67 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii tmem9 34 35
  • 75.58 (n)
wufi33g11 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9265 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007259 34
  • 52.81 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG1161 34
  • 47.07 (n)
worm
(Caenorhabditis elegans)
Secernentea R12C12.6 34 35
  • 46.63 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 33 (a)
OneToMany
Species where no ortholog for TMEM9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TMEM9 Gene

ENSEMBL:
Gene Tree for TMEM9 (if available)
TreeFam:
Gene Tree for TMEM9 (if available)

Paralogs for TMEM9 Gene

Paralogs for TMEM9 Gene

(1) SIMAP similar genes for TMEM9 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with TMEM9: view

Variants for TMEM9 Gene

Sequence variations from dbSNP and Humsavar for TMEM9 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000204387 -- 201,138,097(+) GGACC(A/C)TCTTT intron-variant
rs1000274154 -- 201,159,228(+) ACCTC(C/T)TATAG intron-variant
rs1000317074 -- 201,147,093(+) GGCTC(A/C)AAAAC intron-variant
rs1000344153 -- 201,147,941(+) CCCCA(A/C)CCCCC intron-variant
rs1000418202 -- 201,153,165(+) ACCCT(A/G)AACAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM9 Gene

Variant ID Type Subtype PubMed ID
nsv428301 CNV gain 18775914

Variation tolerance for TMEM9 Gene

Residual Variation Intolerance Score: 40.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.34; 7.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM9 Gene

Human Gene Mutation Database (HGMD)
TMEM9
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM9 Gene

Disorders for TMEM9 Gene

Relevant External Links for TMEM9

Genetic Association Database (GAD)
TMEM9
Human Genome Epidemiology (HuGE) Navigator
TMEM9
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM9

No disorders were found for TMEM9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM9 Gene

Publications for TMEM9 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  2. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64

Products for TMEM9 Gene

Sources for TMEM9 Gene

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