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Aliases for TMEM9 Gene

Aliases for TMEM9 Gene

  • Dermal Papilla-Derived Protein 4 3 4
  • Transmembrane Protein 9 2 3
  • TMEM90B 6
  • SynDIG1 6
  • TMEM9A 3
  • DERP4 4

External Ids for TMEM9 Gene

Previous GeneCards Identifiers for TMEM9 Gene

  • GC00U991238
  • GC01M196562
  • GC01M197570
  • GC01M198392
  • GC01M197835
  • GC01M199370
  • GC01M172270

Summaries for TMEM9 Gene

GeneCards Summary for TMEM9 Gene

TMEM9 is a Protein Coding gene. Diseases associated with TMEM9 include exfoliation syndrome. An important paralog of this gene is TMEM9B.

UniProtKB/Swiss-Prot for TMEM9 Gene

  • May be involved in intracellular transport

Gene Wiki entry for TMEM9 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM9 Gene

Genomics for TMEM9 Gene

Regulatory Elements for TMEM9 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TMEM9 Gene

201,134,771 bp from pter
201,171,582 bp from pter
36,812 bases
Minus strand

Genomic View for TMEM9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM9 Gene

Proteins for TMEM9 Gene

  • Protein details for TMEM9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 9
    Protein Accession:
    Secondary Accessions:
    • B1ALM6
    • Q96NQ9
    • Q9BQF5

    Protein attributes for TMEM9 Gene

    183 amino acids
    Molecular mass:
    20574 Da
    Quaternary structure:
    • Dimer.

neXtProt entry for TMEM9 Gene

Proteomics data for TMEM9 Gene at MOPED

Post-translational modifications for TMEM9 Gene

No data available for DME Specific Peptides for TMEM9 Gene

Domains for TMEM9 Gene

Protein Domains for TMEM9 Gene


Suggested Antigen Peptide Sequences for TMEM9 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q9P0T7
  • Belongs to the TMEM9 family.
genes like me logo Genes that share domains with TMEM9: view

No data available for Gene Families for TMEM9 Gene

Function for TMEM9 Gene

Molecular function for TMEM9 Gene

UniProtKB/Swiss-Prot Function: May be involved in intracellular transport

Gene Ontology (GO) - Molecular Function for TMEM9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with TMEM9: view

Phenotypes for TMEM9 Gene

GenomeRNAi human phenotypes for TMEM9:
genes like me logo Genes that share phenotypes with TMEM9: view

Animal Model Products

CRISPR Products

miRNA for TMEM9 Gene

miRTarBase miRNAs that target TMEM9

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TMEM9 Gene

Localization for TMEM9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM9 Gene

Late endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for TMEM9 Gene COMPARTMENTS Subcellular localization image for TMEM9 gene
Compartment Confidence
endosome 5
lysosome 5
vacuole 5
extracellular 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for TMEM9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005764 lysosome IDA 12359240
GO:0005765 lysosomal membrane IEA --
GO:0005770 late endosome IDA 12359240
GO:0016021 integral component of membrane IEA --
GO:0031902 late endosome membrane IEA --
genes like me logo Genes that share ontologies with TMEM9: view

Pathways for TMEM9 Gene

SuperPathways for TMEM9 Gene

No Data Available

Interacting Proteins for TMEM9 Gene

Selected Interacting proteins: Q9P0T7-TMEM9_HUMAN for TMEM9 Gene via I2D

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for TMEM9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with TMEM9: view

No data available for Pathways by source for TMEM9 Gene

Transcripts for TMEM9 Gene

Unigene Clusters for TMEM9 Gene

Transmembrane protein 9:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM9

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM9 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c · 9d · 9e
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - - -
SP4: - - - -
SP5: - - - - - - - - -
SP6: - - - - -
SP7: - - - - - -
SP8: - -
SP9: - - -

Relevant External Links for TMEM9 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM9 Gene

mRNA expression in normal human tissues for TMEM9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for TMEM9 Gene

SOURCE GeneReport for Unigene cluster for TMEM9 Gene Hs.181444

mRNA Expression by UniProt/SwissProt for TMEM9 Gene

Tissue specificity: Highly expressed in adrenal gland, thyroid gland, testis, ovary and prostate. Moderate expression in trachea, spinal cord, stomach, colon, small intestine and spleen. Low expression in bone marrow, lymph node, thymus and peripheral blood lymphocytes. Expression was detected in hematopoietic cell lines including those of myeloid, erythroid, B- and T-cell origin.
genes like me logo Genes that share expressions with TMEM9: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for TMEM9 Gene

Orthologs for TMEM9 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM9 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMEM9 35
  • 95.37 (n)
  • 95.56 (a)
TMEM9 36
  • 100 (a)
(Bos Taurus)
Mammalia TMEM9 35
  • 87.48 (n)
  • 93.92 (a)
TMEM9 36
  • 94 (a)
(Canis familiaris)
Mammalia -- 36
  • 94 (a)
-- 36
  • 96 (a)
TMEM9 35
  • 91.76 (n)
  • 96.15 (a)
(Mus musculus)
Mammalia Tmem9 35
  • 90.89 (n)
  • 97.27 (a)
Tmem9 16
Tmem9 36
  • 97 (a)
(Monodelphis domestica)
Mammalia TMEM9 36
  • 84 (a)
(Ornithorhynchus anatinus)
Mammalia TMEM9 36
  • 96 (a)
(Rattus norvegicus)
Mammalia Tmem9 35
  • 90.16 (n)
  • 98.36 (a)
(Gallus gallus)
Aves TMEM9 35
  • 80.6 (n)
  • 87.01 (a)
TMEM9 36
  • 74 (a)
(Anolis carolinensis)
Reptilia TMEM9 36
  • 67 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9265 35
(Danio rerio)
Actinopterygii tmem9 35
  • 75.58 (n)
  • 76.74 (a)
tmem9 36
  • 67 (a)
wufi33g11 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007259 35
  • 52.81 (n)
  • 38.76 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1161 35
  • 47.07 (n)
  • 33.94 (a)
(Caenorhabditis elegans)
Secernentea R12C12.6 35
  • 46.63 (n)
  • 33.33 (a)
R12C12.6 36
  • 23 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 33 (a)
Species with no ortholog for TMEM9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TMEM9 Gene

Gene Tree for TMEM9 (if available)
Gene Tree for TMEM9 (if available)

Paralogs for TMEM9 Gene

Paralogs for TMEM9 Gene

Selected SIMAP similar genes for TMEM9 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with TMEM9: view

Variants for TMEM9 Gene

Sequence variations from dbSNP and Humsavar for TMEM9 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs3813 -- 201,134,949(+) CAACC(A/G)ACCGT utr-variant-3-prime, nc-transcript-variant
rs8158 -- 201,143,853(-) GCATA(C/T)ACTGA synonymous-codon, reference, nc-transcript-variant
rs10649 -- 201,134,866(+) ACAAC(A/G/T)AAGTT utr-variant-3-prime, nc-transcript-variant
rs754924 -- 201,136,580(-) CTGTC(C/T)TCAGC intron-variant
rs831743 -- 201,155,395(+) TAGGG(A/G)CTGGG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TMEM9 Gene

Variant ID Type Subtype PubMed ID
nsv428301 CNV Gain 18775914

Relevant External Links for TMEM9 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM9 Gene

Disorders for TMEM9 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for TMEM9 Gene including...

Search for TMEM9 Gene in MalaCards »

(1) University of Copenhagen DISEASES for TMEM9 Gene

Relevant External Links for TMEM9

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with TMEM9: view

No data available for UniProtKB/Swiss-Prot for TMEM9 Gene

Publications for TMEM9 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  2. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 3 4
  3. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4
  4. Characterization of the novel human transmembrane protein 9 (TMEM9) that localizes to lysosomes and late endosomes. (PMID: 12359240) Kveine M. … Rian E. (Biochem. Biophys. Res. Commun. 2002) 3 4
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4

Products for TMEM9 Gene

Sources for TMEM9 Gene

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