TMEM9 Gene
GIFtS: 50
GCID: transmembrane protein 9
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transmembrane protein 9
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Aliases
for TMEM9 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Transmembrane Protein 91 | | TMEM9A1 2 | | Dermal Papilla-Derived Protein 42 3 | | DERP43 |
Export aliases for TMEM9 gene to outside databasesPrevious GC identifer: transmembrane protein 9 |
Summaries
for TMEM9 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: TMEM9_HUMAN, Q9P0T7Function: May be involved in intracellular transport
|
Genomic Views
for TMEM9 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for TMEM9
Other transcription factors
Search SABiosciences Chromatin IP Primers for TMEM9
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM9 |
Genomic Location:
TMEM9 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc Exon Structure GeneLoc location for transmembrane protein 9: view genomic region
(about GC identifiers)
Start:
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0 bp from start of contig transmembrane protein 9 |
End:
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0 bp from start of contig transmembrane protein 9 |
Size:
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1 bases |
Orientation:
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PROBLEM strand |
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Proteins
for TMEM9 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
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|
UniProtKB/Swiss-Prot: TMEM9_HUMAN, Q9P0T7 (See
protein sequence)Recommended Name: Transmembrane protein 9 precursor Size: 183 amino acids; 20574 Da
Subunit: Dimer (Potential)
Subcellular location: Late endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass typeI membrane protein
Secondary accessions: B1ALM6 Q96NQ9 Q9BQF5Explore the universe of human proteins at neXtProt for TMEM9: NX_Q9P0T7
Post-translational modifications:
N-glycosylated1
View neXtProt modification sites for NX_Q9P0T7
TMEM9 Protein expression data from MOPED and PaxDb: About this image 
Human Recombinant Protein Products:
TMEM9 Antibody Products:
Assay Products for TMEM9: |
Protein
Domains /
Families
for TMEM9 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| 1 Blocks protein family: IPB008853 TMEM9
UniProtKB/Swiss-Prot: TMEM9_HUMAN, Q9P0T7Similarity: Belongs to the TMEM9 family |
Function
for TMEM9 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium via
Entrez Gene.)
About This Section
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Function Summary:
UniProtKB/Swiss-Prot: TMEM9_HUMAN, Q9P0T7Function: May be involved in intracellular transport
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Pathways & Interactions
for TMEM9 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium via
Entrez Gene).
About This Section
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Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMEM9
|
Drugs & Compounds
for TMEM9 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TMEM9
Search CenterWatch for drugs/clinical trials and news about TMEM9 
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Transcripts
for TMEM9 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
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Unigene Cluster for TMEM9: Transmembrane protein 9 Hs.181444 [show with all ESTs]Unigene Representative Sequence: AK094588
Additional cDNA sequence: AB013909.1 AF151020.1 AK054883.1 AK075335.1 AK091726.1 AK094588.1 AK296307.1 AK303843.1 AL136600.1 AY138587.1 AY359012.1 BC001106.2 CR457162.1 CR533467.1 18 DOTS entries: DT.447561 DT.101962517 DT.100827520 DT.100827515 DT.101982822 DT.99980739 DT.100827516 DT.100671856 DT.100827510 DT.121409511 DT.100043099 DT.121409551 DT.100044830 DT.100827514 DT.100827525 DT.95266638 DT.95266639 DT.97860052
GeneLoc Exon Structure
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Expression
for TMEM9 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TMEM9 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See TMEM9 Protein Expression from SPIRE MOPED and PaxDBUniProtKB/Swiss-Prot: TMEM9_HUMAN, Q9P0T7Tissue specificity: Highly expressed in adrenal gland, thyroid gland, testis, ovary and prostate. Moderate expressionin trachea, spinal cord, stomach, colon, small intestine and spleen. Low expression in bone marrow, lymph node, thymusand peripheral blood lymphocytes. Expression was detected in hematopoietic cell lines including those of myeloid,erythroid, B- and T-cell origin
SABiosciences Custom PCR Arrays for TMEM9
Primer
Products: |  | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat TMEM9 | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM9 | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM9 |
Orthologs
for TMEM9 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of human and mouse.
Orthologs for TMEM9 gene from 1 species (see representative species ) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Tmem95 |
transmembrane protein 9 |
-- |
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1 (59.51 cM) 136017967 |
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Paralogs
for TMEM9 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build )
About This Section
| -- |
Genomic Variants
for TMEM9 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
Human Gene Mutation Database (HGMD): TMEM9
| SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for TMEM9 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 TMEM9 for disorders About MalaCards
TMEM9 for disorders About GeneDecksing
Export disorders for TMEM9 gene to outside databases
|
Publications
for TMEM9 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TMEM9 gene, integrated from 9 sources (see all 25):
(articles sorted by number of sources associating them with TMEM9) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- Characterization of the novel human transmembrane protein 9 (TMEM9) that localizes to lysosomes and late endosomes. (PubMed id 12359240)1, 2 Kveine M.... Rian E. (2002)
- Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
- Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2 Zhang Q.-H.... Chen Z. (2000)
- Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (2012)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
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External Searches for TMEM9 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing TMEM9 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
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Other Databases showing TMEM9 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TMEM9 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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About This Section
| Patent Information for TMEM9 gene:
Search GeneIP for patents involving TMEM9
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for TMEM9 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TMEM9 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMEM9 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM9 | | | Search QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMEM9 | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM9 | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM9 |
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| | | | Search Tocris compounds for TMEM9 |
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 | | | | |  |  |  | | | | Search ThermoFisher Antibodies for TMEM9 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TMEM9 |
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