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TMEM8B Gene

protein-coding   GIFtS: 49
GCID: GC09P035814

Transmembrane Protein 8B

(Previous name: chromosome 9 open reading frame 127)
(Previous symbol: C9orf127)
  See TMEM8B-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Transmembrane Protein 8B1 2     NGX62 3
C9orf1271 2 3     Protein NGX62 3
Nasopharyngeal Carcinoma Expressed 61 2     Chromosome 9 Open Reading Frame 1271
Nasopharyngeal Carcinoma-Associated Gene 6 Protein2 3     NAG-52
Protein NAG-52 3     Nasopharyngeal Carcinoma Related Protein2

External Ids:    HGNC: 214271   Entrez Gene: 517542   Ensembl: ENSG000001371037   UniProtKB: A6NDV43   

Export aliases for TMEM8B gene to outside databases

Previous GC identifer: GC09P035785


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TMEM8B Gene:
TMEM8B (transmembrane protein 8B) is a protein-coding gene. Diseases associated with TMEM8B include nasopharynx carcinoma. An important paralog of this gene is TMEM8A.

UniProtKB/Swiss-Prot: TMM8B_HUMAN, A6NDV4
Function: May function as a regulator of the EGFR pathway. Probable tumor suppressor which may function in cell
growth, proliferation and adhesion

Gene Wiki entry for TMEM8B (C9orf127) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NT_008413.19  NC_018920.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for TMEM8B
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): TMEM8B promoter sequence
   Search Chromatin IP Primers for TMEM8B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TMEM8B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p13.3   Ensembl cytogenetic band:  9p13.3   HGNC cytogenetic band: 9p13.3

TMEM8B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM8B gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P035814:  view genomic region     (about GC identifiers)

Start:
35,814,448 bp from pter      End:
35,854,844 bp from pter
Size:
40,397 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TMM8B_HUMAN, A6NDV4 (See protein sequence)
Recommended Name: Transmembrane protein 8B  
Size: 472 amino acids; 51941 Da
Subunit: Isoform 2 (via its cytoplasmic part) interacts with EZR
Sequence caution: Sequence=AAC28644.1; Type=Erroneous initiation; Sequence=AAF34820.1; Type=Erroneous initiation;
Note=Translation N-terminally shortened; Sequence=AAF34820.1; Type=Miscellaneous discrepancy; Note=Contaminating
sequence. Sequence of unknown origin in the N-terminal part;
Secondary accessions: B3KQF3 O75539 Q49AB1 Q4KMX5 Q5TCW5 Q9HBY2 Q9P0U7
Alternative splicing: 3 isoforms:  A6NDV4-1   A6NDV4-2   A6NDV4-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TMEM8B: NX_A6NDV4

Explore proteomics data for TMEM8B at MOPED

Post-translational modifications: 

  • Isoform 2 is N-glycosylated1
  • Ubiquitination2 at Lys197
  • Glycosylation2 at Asn92, Asn100

  • See TMEM8B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001036054.1  NP_001036055.1  NP_057530.2  

    ENSEMBL proteins: 
     ENSP00000367235   ENSP00000395810   ENSP00000367230   ENSP00000367227  

    TMEM8B Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for TMEM8B

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR000742 EG-like_dom
     IPR013032 EGF-like_CS
     IPR021910 DUF3522

    Graphical View of Domain Structure for InterPro Entry A6NDV4

    ProtoNet protein and cluster: A6NDV4

    UniProtKB/Swiss-Prot: TMM8B_HUMAN, A6NDV4
    Similarity: Belongs to the TMEM8 family
    Similarity: Contains 1 EGF-like domain


    Find genes that share domains with TMEM8B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TMM8B_HUMAN, A6NDV4
    Function: May function as a regulator of the EGFR pathway. Probable tumor suppressor which may function in cell
    growth, proliferation and adhesion
    Induction: Isoform 2 is down-regulated in nasopharyngeal carcinoma cells

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15498789
         
    Find genes that share ontologies with TMEM8B           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for TMEM8B:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TMEM8B
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    miRTarBase miRNAs that target TMEM8B:
    hsa-mir-335-5p (MIRT018101), hsa-mir-324-5p (MIRT043252)

    Block miRNA regulation of human, mouse, rat TMEM8B using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate TMEM8B:
    hsa-miR-186* hsa-miR-516a-3p hsa-miR-516b* hsa-miR-3653 hsa-miR-4308
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Browse Sino Biological Human cDNA Clones
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TMM8B_HUMAN, A6NDV4: Isoform 2: Cell membrane; Multi-pass membrane protein (Probable). Cytoplasm (Probable).
    Nucleus (Probable). Mitochondrion. Endoplasmic reticulum. Note=Also detected in mitochondrion and endoplasmic
    reticulum
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    mitochondrion5
    plasma membrane5
    nucleus4

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005739mitochondrion IEA--
    GO:0005783endoplasmic reticulum IEA--
    GO:0005886plasma membrane IDA15498789
    GO:0009986cell surface IDA15498789

    Find genes that share ontologies with TMEM8B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TMEM8B
    Interactions:

        GeneGlobe Interaction Network for TMEM8B

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    3 Interacting proteins for TMEM8B (A6NDV42, 3 ENSP000003672274) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EZRP153113, ENSP000003389344I2D: score=2 STRING: ENSP00000338934
    SH3GL2Q999623I2D: score=1 
    --XM_292512.32MINT-2873614
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006952defense response ----
    GO:0007160cell-matrix adhesion IMP15498789
    GO:0007346regulation of mitotic cell cycle TAS15498789
    GO:0040008regulation of growth IEA--

    Find genes that share ontologies with TMEM8B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TMEM8B (TMM8B)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TMEM8B gene (3 alternative transcripts): 
    NM_001042589.2  NM_001042590.2  NM_016446.3  

    Unigene Cluster for TMEM8B:

    Transmembrane protein 8B
    Hs.493808  [show with all ESTs]
    Unigene Representative Sequence: NM_001042590
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000377996 ENST00000439587(uc003zyk.3) ENST00000377991(uc003zym.3)
    ENST00000464519 ENST00000473947 ENST00000472010 ENST00000490199 ENST00000377988(uc003zyn.3 uc003zyo.3)

    miRNA
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    Block miRNA regulation of human, mouse, rat TMEM8B using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate TMEM8B:
    hsa-miR-186* hsa-miR-516a-3p hsa-miR-516b* hsa-miR-3653 hsa-miR-4308
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 3): TMEM8B (NM_016446)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM8B
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat TMEM8B
      QuantiTect SYBR Green Assays in human, mouse, rat TMEM8B
      QuantiFast Probe-based Assays in human, mouse, rat TMEM8B

    Additional mRNA sequence: 

    AF070572.1 AF188239.1 AK074844.1 BC043384.1 BC064951.1 BC082765.1 BC098265.1 BC098296.1 
    BC099733.1 

    11 DOTS entries:

    DT.100806215  DT.108476  DT.121165138  DT.438424  DT.40308515  DT.97801621  DT.100010162  DT.437144 
    DT.95239336  DT.121165156  DT.95167360 

    Selected AceView cDNA sequences (see all 107):

    AI637832 AA449507 BI711178 AI521416 BM977883 BQ945856 BE675594 BM468607 
    AI002771 AA837043 BC043384 BM554267 BC064951 BE391614 CB242773 BX282158 
    AI818893 BX094772 AA171488 AI093854 BU856426 BF843007 CD517650 AF070572 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TMEM8B (see all 14)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                -     -     -     -     -     -     -     -     -     -     -     -                                                         
    SP4:                                -     -     -     -                                                     -                                                   
    SP5:                                                                                                        -                                                   

    ExUns: 13a · 13b ^ 14 ^ 15 ^ 16a · 16b
    SP1:  -                                 
    SP2:  -                                 
    SP3:                                    
    SP4:                                    
    SP5:                                    


    ECgene alternative splicing isoforms for TMEM8B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TMEM8B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACTCTGGAA
    TMEM8B Expression
    About this image

    TMEM8B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TMEM8B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.493808
        Custom PCR Arrays for TMEM8B
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM8B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TMEM8B gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tmem8b1 , 5 transmembrane protein 8B1, 5 89.83(n)1
    96.4(a)1
      4 (23.05 cM)5
    2424091  NM_001085508.21  NP_001078977.11 
     436689715 
    chicken
    (Gallus gallus)
    Aves TMEM8B1 transmembrane protein 8B 75(n)
    76.48(a)
      769808  XM_001233114.3  XP_001233115.3 
    lizard
    (Anolis carolinensis)
    Reptilia TMEM8B6
    transmembrane protein 8B
    76(a)
    1 ↔ 1
    GL344461.1(17557-32030)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia tmem8b1 transmembrane protein 8B 69.66(n)
    70.59(a)
      100380140  XM_002943427.2  XP_002943473.2 
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkey-84j12.11 si:dkey-84j12.1 69.21(n)
    72.25(a)
      563965  XM_001920797.4  XP_001920832.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG136546
    --
    14(a)
    1 → many
    3R(21025540-21039371)


    ENSEMBL Gene Tree for TMEM8B (if available)
    TreeFam Gene Tree for TMEM8B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TMEM8B gene
    TMEM8A2  TMEM8C2  
    2 SIMAP similar genes for TMEM8B using alignment to 1 protein entry:     TMM8B_HUMAN:
    TMEM8A    TMEM8C

    Find genes that share paralogs with TMEM8B           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TMEM8B (see all 565)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs357212481,2
    C,F--35783298(+) CACCCA/GTTCTT 1 -- us2k18Minor allele frequency- G:0.24NA WA CSA EA 368
    rs1389485171,2
    --35783316(+) TTTATA/GTAACT 1 -- us2k10--------
    rs1881342441,2
    --35783392(+) TTGAGA/TCTAGG 1 -- us2k10--------
    rs1916258971,2
    --35783444(+) ATGTTA/GTTCTG 1 -- us2k10--------
    rs1841042141,2
    --35783501(+) CTGCAA/TGGATG 1 -- us2k10--------
    rs1889253341,2
    --35783546(+) AAAGTA/GCAAGC 1 -- us2k10--------
    rs749659951,2
    F--35783707(+) CCCCCA/GTGTTC 1 -- us2k11Minor allele frequency- G:0.13WA 118
    rs1489717001,2
    C--35783999(+) CAAGGA/CGGGTG 1 -- us2k10--------
    rs1922632491,2
    --35784090(+) TGGGCA/GTGGTG 1 -- us2k10--------
    rs1437767101,2
    --35784129(+) GAGGCC/TGAAGC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TMEM8B (35814448 - 35854844 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for TMEM8B:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv831546CNV Loss17160897
    dgv8168n71CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TMEM8B
    DNA2.0 Custom Variant and Variant Library Synthesis for TMEM8B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease for TMEM8B:    
    About MalaCards
    nasopharynx carcinoma

    1 disease from the University of Copenhagen DISEASES database for TMEM8B:
    Nasopharynx carcinoma

    Find genes that share disorders with TMEM8B           About GenesLikeMe

    Genetic Association Database (GAD): TMEM8B
    Human Genome Epidemiology (HuGE) Navigator: TMEM8B (1 document)

    Export disorders for TMEM8B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TMEM8B gene, integrated from 10 sources (see all 24):
    (articles sorted by number of sources associating them with TMEM8B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The expression of ezrin in NPC and its interaction with NGX6, a novel candidate suppressor. (PubMed id 17270023)1, 2 Peng S.-P.... Li G.-Y. (Cancer Sci. 2007)
    2. The role of NGX6 and its deletion mutants in the proliferation, adhesion and migration of nasopharyngeal carcinoma 5-8F cells. (PubMed id 17641538)1, 2 Peng S.P.... Li G.-Y. (Oncology 2006)
    3. Role of a novel EGF-like domain-containing gene NGX6 in cell adhesion modulation in nasopharyngeal carcinoma cells. (PubMed id 15498789)1, 2 Ma J.... Li G.-Y. (Carcinogenesis 2005)
    4. NGX6 gene inhibits cell proliferation and plays a negative role in EGFR pathway in nasopharyngeal carcinoma cells. (PubMed id 15723283)1, 2 Wang L.-L.... Li G.-Y. (J. Cell. Biochem. 2005)
    5. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (Nature 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Expression of tumor related genes NGX6, NAG-7, BRD7 in gastric and colorectal cancer. (PubMed id 12918109)1, 3 Zhang X.M....Li J. (World J. Gastroenterol. 2003)
    8. Proteomic detection of changes in protein synthesis induced by NGX6 transfected in human nasopharyngeal carcinoma cells. (PubMed id 11565907)1, 2 Li J.... Li G.-Y. (J. Protein Chem. 2001)
    9. A "double adaptor" method for improved shotgun library construction. (PubMed id 8619474)1, 3 Andersson B.... Gibbs R.A. (Anal. Biochem. 1996)
    10. NGX6 expression improves the sensitivity of tamoxifen-resistant MCF-7 cells through modulation of the Smad signaling pathway. (PubMed id 23588848)1 Zhao W.J. and Wang K. (Int. J. Oncol. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
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    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51754 HGNC: 21427 AceView: C9orf127 Ensembl:ENSG00000137103 euGenes: HUgn51754
    ECgene: TMEM8B H-InvDB: TMEM8B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TMEM8B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TMEM8B gene:
    Search GeneIP for patents involving TMEM8B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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