TMEM8B Gene
protein-coding GIFtS: 48
GCID: GC09P035814
|
|
transmembrane protein 8B(Previous name: chromosome 9 open reading frame 127 )
(Previous symbol: C9orf127)
| |
Aliases
for TMEM8B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Transmembrane Protein 8B1 2 | | Protein NGX62 3 | | C9orf1271 2 3 | | Chromosome 9 Open Reading Frame 1271 | | NGX61 2 3 | | RP11-112J3.102 | | NAG-51 2 | | Nasopharyngeal Carcinoma Expressed 62 | | Nasopharyngeal Carcinoma-Associated Gene 6 Protein2 3 | | Nasopharyngeal Carcinoma Related Protein2 | | Protein NAG-52 3 | | |
Export aliases for TMEM8B gene to outside databasesPrevious GC identifer: GC09P035785 |
Summaries
for TMEM8B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: TMM8B_HUMAN, A6NDV4Function: May function as a regulator of the EGFR pathway. Probable tumor suppressor which may function in cell growth,proliferation and adhesion
Gene Wiki entry for TMEM8B (C9orf127)
|
Genomic Views
for TMEM8B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_008413.18
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for TMEM8B
Other transcription factors
Search SABiosciences Chromatin IP Primers for TMEM8B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM8B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9p13.3 Ensembl cytogenetic band: 9p13.3 HGNC cytogenetic band: 9p13.3TMEM8B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09P035814: view genomic region
(about GC identifiers)
Start:
|
35,814,448 bp from pter |
End:
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35,854,844 bp from pter |
Size:
|
40,397 bases |
Orientation:
|
plus strand |
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Proteins
for TMEM8B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TMM8B_HUMAN, A6NDV4 (See
protein sequence)Recommended Name: Transmembrane protein 8B Size: 472 amino acids; 51941 Da
Subunit: Isoform 2 (via its cytoplasmic part) interacts with EZR
Subcellular location: Isoform 2: Cell membrane; Multi-pass membrane protein (Probable). Cytoplasm (Probable). Nucleus(Probable). Mitochondrion. Endoplasmic reticulum. Note=Also detected in mitochondrion and endoplasmic reticulum
Sequence caution: Sequence=AAC28644.1; Type=Erroneous initiation; Sequence=AAF34820.1; Type=Erroneous initiation;Note=Translation N-terminally shortened; Sequence=AAF34820.1; Type=Miscellaneous discrepancy; Note=Contaminatingsequence. Sequence of unknown origin in the N-terminal part;
Secondary accessions: B3KQF3 O75539 Q49AB1 Q4KMX5 Q5TCW5 Q9HBY2 Q9P0U7Alternative splicing: 3 isoforms: A6NDV4-1 A6NDV4-2 A6NDV4-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for TMEM8B: NX_A6NDV4
Post-translational modifications:
Isoform 2 is N-glycosylated1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_A6NDV4
TMEM8B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001036054.1 NP_001036055.1 NP_057530.2
ENSEMBL proteins: ENSP00000367235 ENSP00000395810 ENSP00000367230 ENSP00000367227
Human Recombinant Protein Products:
Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table
TMEM8B for ontologies About GeneDecksing
TMEM8B Antibody Products:
Assay Products for TMEM8B: |
Protein
Domains /
Families
for TMEM8B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TMEM8B for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry A6NDV4ProtoNet protein and cluster: A6NDV4 UniProtKB/Swiss-Prot: TMM8B_HUMAN, A6NDV4Similarity: Belongs to the TMEM8 familySimilarity: Contains 1 EGF-like domain |
Function
for TMEM8B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TMM8B_HUMAN, A6NDV4Function: May function as a regulator of the EGFR pathway. Probable tumor suppressor which may function in cell growth,proliferation and adhesionInduction: Isoform 2 is down-regulated in nasopharyngeal carcinoma cells
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM8B (see all 3)
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variant library, vector shuttling 
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Synthesis Service for TMEM8B | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM8B |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM8B |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table
TMEM8B for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for TMEM8B:
|
Pathways & Interactions
for TMEM8B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TMEM8B
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
3 Interacting proteins for TMEM8B (A6NDV42, 3 ENSP000003672274) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
TMEM8B for ontologies About GeneDecksing
|
Drugs & Compounds
for TMEM8B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TMEM8B
Search CenterWatch for drugs/clinical trials and news about TMEM8B / TMM8B
|
Transcripts
for TMEM8B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TMEM8B gene (3 alternative transcripts): NM_001042589.2 NM_001042590.2 NM_016446.3 Unigene Cluster for TMEM8B: Transmembrane protein 8B Hs.493808 [show with all ESTs]Unigene Representative Sequence: NM_0010425908 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000377996 ENST00000439587(uc003zyk.3) ENST00000377991(uc003zym.3)
ENST00000464519 ENST00000473947 ENST00000472010 ENST00000490199 ENST00000377988(uc003zyn.3 uc003zyo.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM8B (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM8B (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): TMEM8B (NM_016446) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMEM8B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM8B |
Additional cDNA sequence: AF070572.1 AF188239.1 AK074844.1 BC043384.1 BC064951.1 BC082765.1 BC098265.1 BC098296.1 BC099733.1 12 DOTS entries: DT.100806215 DT.108476 DT.121165138 DT.438424 DT.40308515 DT.100010162 DT.97801621 DT.437144 DT.95239336 DT.100779858 DT.121165156 DT.95167360 24/107 AceView cDNA sequences (see all 107): BC064951 BF843007 BM554267 CD517650 BQ945856 AA837043 BM977883 AI521416 BM468607 BI711178 CB242773 AI093854 BM713915 AA449507 AA171488 BX282158 AF070572 BE675594 BE391614 AI818893 BX094772 BU738753 BC082765 BU856426
GeneLoc Exon Structure
5/14 Alternative Splicing Database (ASD) splice patterns (SP) for TMEM8B (see all 14) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | · | 3c | · | 3d | ^ | 4a | · | 4b | · | 4c | · | 4d | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | · | 6c | · | 6d | ^ | 7 | ^ | 8a | · | 8b | · | 8c | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ |
|---|
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| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | |
| ExUns: | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b |
|---|
|
| SP1: | - | | | | | | | | | | | | |
| SP2: | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | |
ECgene alternative splicing isoforms for TMEM8B
|
Expression
for TMEM8B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TMEM8B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GACTCTGGAA
About this image
See TMEM8B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TMEM8B
SOURCE GeneReport for Unigene cluster: Hs.493808
SABiosciences Custom PCR Arrays for TMEM8B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM8B
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM8B |
Orthologs
for TMEM8B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for TMEM8B gene from 4/13 species (see all 13) About this table
ENSEMBL Gene Tree for TMEM8B (if available)
TreeFam Gene Tree for TMEM8B (if available) |
Paralogs
for TMEM8B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TMEM8B gene
- TMEM8A2 TMEM8C2
2 SIMAP similar genes for TMEM8B using alignment to 1 protein entry: TMM8B_HUMAN:TMEM8A TMEM8C
TMEM8B for paralogs About GeneDecksing
|
Genomic Variants
for TMEM8B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TMEM8B (35814448 - 35854844 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TMEM8B: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMEM8B |
|
Disorders
/ Diseases
for TMEM8B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TMEM8B for disorders About GeneDecksing
5  diseases for TMEM8B: About MalaCardsnasopharyngitis carcinoma nasopharynx carcinoma colon cancer
colorectal cancer
1 disease from the University of Copenhagen DISEASES database for TMEM8B:Nasopharynx carcinoma Human Genome Epidemiology (HuGE) Navigator: TMEM8B (1 document)
Export disorders for TMEM8B gene to outside databases
|
Publications
for TMEM8B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TMEM8B gene, integrated from 9 sources (see all 22):
(articles sorted by number of sources associating them with TMEM8B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The expression of ezrin in NPC and its interaction with NGX6, a novel candidate suppressor. (PubMed id 17270023)1, 2 Peng S.-P.... Li G.-Y. (2007)
- The role of NGX6 and its deletion mutants in the proliferation, adhesion and migration of nasopharyngeal carcinoma 5-8F cells. (PubMed id 17641538)1, 2 Peng S.P.... Li G.-Y. (2006)
- Role of a novel EGF-like domain-containing gene NGX6 in cell adhesion modulation in nasopharyngeal carcinoma cells. (PubMed id 15498789)1, 2 Ma J....Li G. (2005)
- NGX6 gene inhibits cell proliferation and plays a negative role in EGFR pathway in nasopharyngeal carcinoma cells. (PubMed id 15723283)1, 2 Wang L.-L.... Li G.-Y. (2005)
- DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Expression of tumor related genes NGX6, NAG-7, BRD7 in gastric and colorectal cancer. (PubMed id 12918109)1, 3 Zhang X.M....Li J. (2003)
- Proteomic detection of changes in protein synthesis induced by NGX6 transfected in human nasopharyngeal carcinoma cells. (PubMed id 11565907)1, 2 Li J....Li G. (2001)
- A "double adaptor" method for improved shotgun library construction. (PubMed id 8619474)1, 3 Andersson B.... Gibbs R.A. (1996)
- Tumor suppressor gene NGX6 induces changes in protein expression profiles in colon cancer HT-29 cells. (PubMed id 22647848)1 Li Y....Su Z. (2012)
|
External Searches for TMEM8B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TMEM8B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TMEM8B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TMEM8B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TMEM8B | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TMEM8B gene:
Search GeneIP for patents involving TMEM8B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TMEM8B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM8B |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM8B |
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