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Aliases for TMEM8B Gene

Aliases for TMEM8B Gene

  • Nasopharyngeal Carcinoma-Associated Gene 6 Protein 3 4
  • Nasopharyngeal Carcinoma Expressed 6 2 3
  • Transmembrane Protein 8B 2 3
  • Protein NAG-5 3 4
  • Protein NGX6 3 4
  • C9orf127 3 4
  • NGX6 3 4
  • Nasopharyngeal Carcinoma Related Protein 3
  • Chromosome 9 Open Reading Frame 127 2
  • NAG-5 3

External Ids for TMEM8B Gene

Previous HGNC Symbols for TMEM8B Gene

  • C9orf127

Previous GeneCards Identifiers for TMEM8B Gene

  • GC09P035814

Summaries for TMEM8B Gene

GeneCards Summary for TMEM8B Gene

TMEM8B is a Protein Coding gene. Diseases associated with TMEM8B include nasopharyngeal carcinoma and nasopharynx carcinoma. An important paralog of this gene is TMEM8C.

UniProtKB/Swiss-Prot for TMEM8B Gene

  • May function as a regulator of the EGFR pathway. Probable tumor suppressor which may function in cell growth, proliferation and adhesion.

Gene Wiki entry for TMEM8B Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM8B Gene

Genomics for TMEM8B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TMEM8B Gene

35,814,451 bp from pter
35,854,847 bp from pter
40,397 bases
Plus strand

Genomic View for TMEM8B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM8B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM8B Gene

No data available for Regulatory Elements for TMEM8B Gene

Proteins for TMEM8B Gene

  • Protein details for TMEM8B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 8B
    Protein Accession:
    Secondary Accessions:
    • B3KQF3
    • O75539
    • Q49AB1
    • Q4KMX5
    • Q5TCW5
    • Q9HBY2
    • Q9P0U7

    Protein attributes for TMEM8B Gene

    472 amino acids
    Molecular mass:
    51941 Da
    Quaternary structure:
    • Isoform 2 (via its cytoplasmic part) interacts with EZR.
    • Sequence=AAC28644.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAF34820.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAF34820.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305};

    Alternative splice isoforms for TMEM8B Gene


neXtProt entry for TMEM8B Gene

Proteomics data for TMEM8B Gene at MOPED

Post-translational modifications for TMEM8B Gene

Other Protein References for TMEM8B Gene

Antibody Products

No data available for DME Specific Peptides for TMEM8B Gene

Domains for TMEM8B Gene

Protein Domains for TMEM8B Gene


Suggested Antigen Peptide Sequences for TMEM8B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • A6NDV4
  • Contains 1 EGF-like domain.
  • Belongs to the TMEM8 family.
genes like me logo Genes that share domains with TMEM8B: view

No data available for Gene Families for TMEM8B Gene

Function for TMEM8B Gene

Molecular function for TMEM8B Gene

UniProtKB/Swiss-Prot Function:
May function as a regulator of the EGFR pathway. Probable tumor suppressor which may function in cell growth, proliferation and adhesion.
UniProtKB/Swiss-Prot Induction:
Isoform 2 is down-regulated in nasopharyngeal carcinoma cells.

Gene Ontology (GO) - Molecular Function for TMEM8B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15498789
genes like me logo Genes that share ontologies with TMEM8B: view

Phenotypes for TMEM8B Gene

GenomeRNAi human phenotypes for TMEM8B:
genes like me logo Genes that share phenotypes with TMEM8B: view

Animal Model Products

CRISPR Products

miRNA for TMEM8B Gene

miRTarBase miRNAs that target TMEM8B

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TMEM8B Gene

Localization for TMEM8B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM8B Gene

Isoform 2: Cell membrane; Multi-pass membrane protein. Cytoplasm. Nucleus. Mitochondrion. Endoplasmic reticulum. Note=Also detected in mitochondrion and endoplasmic reticulum.

Subcellular locations from

Jensen Localization Image for TMEM8B Gene COMPARTMENTS Subcellular localization image for TMEM8B gene
Compartment Confidence
endoplasmic reticulum 5
mitochondrion 5
plasma membrane 5
nucleus 4

Gene Ontology (GO) - Cellular Components for TMEM8B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005739 mitochondrion IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005886 plasma membrane IDA 15498789
GO:0009986 cell surface IDA 15498789
genes like me logo Genes that share ontologies with TMEM8B: view

Pathways for TMEM8B Gene

SuperPathways for TMEM8B Gene

No Data Available

Interacting Proteins for TMEM8B Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: A6NDV4-TMM8B_HUMAN ENSP00000367227 for TMEM8B Gene via MINT STRING I2D

Gene Ontology (GO) - Biological Process for TMEM8B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006952 defense response --
GO:0007160 cell-matrix adhesion IMP 15498789
GO:0007346 regulation of mitotic cell cycle TAS 15498789
GO:0040008 regulation of growth IEA --
genes like me logo Genes that share ontologies with TMEM8B: view

No data available for Pathways by source for TMEM8B Gene

Transcripts for TMEM8B Gene

Unigene Clusters for TMEM8B Gene

Transmembrane protein 8B:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM8B

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM8B Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^
SP3: - - - - - - - - - - - -
SP4: - - - - -
SP5: -
SP6: - - - - - - - - -
SP7: - - - - - - - - - -
SP8: - - - -
SP9: - - -
SP10: - - - -
SP11: -
SP13: - - - - - - - - -
SP14: - - - - - - - - - -

ExUns: 13a · 13b ^ 14 ^ 15 ^ 16a · 16b
SP1: -
SP2: -
SP6: -

Relevant External Links for TMEM8B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM8B Gene

mRNA expression in normal human tissues for TMEM8B Gene

SOURCE GeneReport for Unigene cluster for TMEM8B Gene Hs.493808

genes like me logo Genes that share expressions with TMEM8B: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for TMEM8B Gene

Orthologs for TMEM8B Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM8B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TMEM8B 35
  • 91.38 (n)
  • 97.03 (a)
  • 62 (a)
(Canis familiaris)
Mammalia TMEM8B 35
  • 93.08 (n)
  • 97.46 (a)
  • 97 (a)
(Mus musculus)
Mammalia Tmem8b 35
  • 89.83 (n)
  • 96.4 (a)
Tmem8b 16
Tmem8b 36
  • 96 (a)
(Pan troglodytes)
Mammalia TMEM8B 35
  • 99.65 (n)
  • 99.58 (a)
  • 44 (a)
(Rattus norvegicus)
Mammalia Tmem8b 35
  • 89.97 (n)
  • 96.61 (a)
(Monodelphis domestica)
Mammalia TMEM8B 36
  • 47 (a)
(Ornithorhynchus anatinus)
Mammalia TMEM8B 36
  • 45 (a)
(Gallus gallus)
Aves TMEM8B 35
  • 75 (n)
  • 76.48 (a)
  • 44 (a)
(Anolis carolinensis)
Reptilia TMEM8B 36
  • 76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem8b 35
  • 69.66 (n)
  • 70.59 (a)
(Danio rerio)
Actinopterygii si:dkey-84j12.1 35
  • 69.21 (n)
  • 72.25 (a)
si:dkey-84j12.1 36
  • 13 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG13654 36
  • 14 (a)
Species with no ortholog for TMEM8B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM8B Gene

Gene Tree for TMEM8B (if available)
Gene Tree for TMEM8B (if available)

Paralogs for TMEM8B Gene

Paralogs for TMEM8B Gene

Selected SIMAP similar genes for TMEM8B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TMEM8B: view

Variants for TMEM8B Gene

Sequence variations from dbSNP and Humsavar for TMEM8B Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs1407297 -- 35,847,759(+) AGAAT(C/T)GCCAC intron-variant
rs1407298 -- 35,848,191(+) AAGAG(G/T)CTGCA intron-variant
rs1885371 -- 35,837,862(+) CAGTC(C/T)GCTCT intron-variant
rs1885372 -- 35,838,033(+) GAAGA(A/G)GTCGA intron-variant
rs2093400 -- 35,838,846(+) CACAA(C/G)CAATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM8B Gene

Variant ID Type Subtype PubMed ID
dgv8168n71 CNV Gain 21882294
nsv831546 CNV Loss 17160897

Relevant External Links for TMEM8B Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM8B Gene

Disorders for TMEM8B Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for TMEM8B Gene in MalaCards »

(2) Diseases for TMEM8B Gene including...

(1) University of Copenhagen DISEASES for TMEM8B Gene

Relevant External Links for TMEM8B

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with TMEM8B: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for TMEM8B Gene

Publications for TMEM8B Gene

  1. A "double adaptor" method for improved shotgun library construction. (PMID: 8619474) Andersson B. … Gibbs R.A. (Anal. Biochem. 1996) 2 3
  2. Proteomic detection of changes in protein synthesis induced by NGX6 transfected in human nasopharyngeal carcinoma cells. (PMID: 11565907) Li J. … Li G.-Y. (J. Protein Chem. 2001) 3 4
  3. Expression of tumor related genes NGX6, NAG-7, BRD7 in gastric and colorectal cancer. (PMID: 12918109) Zhang X.M. … Li J. (World J. Gastroenterol. 2003) 2 3
  4. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for TMEM8B Gene

Sources for TMEM8B Gene

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