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Aliases for TMEM8B Gene

Aliases for TMEM8B Gene

  • Transmembrane Protein 8B 2 3 5
  • Nasopharyngeal Carcinoma-Associated Gene 6 Protein 3 4
  • Nasopharyngeal Carcinoma Expressed 6 2 3
  • Protein NAG-5 3 4
  • Protein NGX6 3 4
  • C9orf127 3 4
  • NGX6 3 4
  • Nasopharyngeal Carcinoma Related Protein 3
  • Chromosome 9 Open Reading Frame 127 2
  • NAG-5 3
  • NAG5 3

External Ids for TMEM8B Gene

Previous HGNC Symbols for TMEM8B Gene

  • C9orf127

Previous GeneCards Identifiers for TMEM8B Gene

  • GC09P035814

Summaries for TMEM8B Gene

GeneCards Summary for TMEM8B Gene

TMEM8B (Transmembrane Protein 8B) is a Protein Coding gene. Diseases associated with TMEM8B include Nasopharyngeal Carcinoma and Pharynx Cancer. An important paralog of this gene is TMEM8A.

UniProtKB/Swiss-Prot for TMEM8B Gene

  • May function as a regulator of the EGFR pathway. Probable tumor suppressor which may function in cell growth, proliferation and adhesion.

Gene Wiki entry for TMEM8B Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM8B Gene

Genomics for TMEM8B Gene

Regulatory Elements for TMEM8B Gene

Enhancers for TMEM8B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09G035831 1.5 Ensembl ENCODE dbSUPER 46 +19.7 19734 5.0 HDGF PKNOX1 SIN3A DMAP1 YY1 TBX21 PPARG KAT8 GLIS1 ETV4 TMEM8B TPM2 FAM221B LINC00950
GH09G035726 1.7 FANTOM5 ENCODE dbSUPER 31 -84.0 -84037 8.6 CREB3L1 MLX AGO1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF263 SP3 TMEM8B GBA2 TPM2 TLN1 ARHGEF39 RN7SL22P ENSG00000228843 MSMP CCDC107 CA9
GH09G035828 0.9 ENCODE 39.2 +15.1 15147 2.2 HDGF ATF1 FOXA2 PKNOX1 KLF17 SIN3A BMI1 ZNF48 ZBTB40 YY1 TMEM8B TPM2 FAM221B HINT2
GH09G035679 1.5 Ensembl ENCODE dbSUPER 22.4 -128.3 -128334 12.8 PKNOX1 ARID4B SIN3A GLIS2 ELK1 FOS ZNF263 SP3 SMARCB1 MBD2 TPM2 GBA2 TMEM8B TLN1 NPR2 CCDC107 SIT1 CREB3 RGP1 MSMP
GH09G035904 1.8 FANTOM5 Ensembl ENCODE dbSUPER 17.6 +93.7 93717 7.4 FOXA2 SIN3A ZNF48 YY1 SLC30A9 ZNF121 GLIS2 GATA2 ZNF143 FOS HRCT1 SPAAR TMEM8B OR13J1 FAM221B NDUFA5P4 ENSG00000227388 NPR2 SPAG8 OR2S1P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM8B on UCSC Golden Path with GeneCards custom track

Promoters for TMEM8B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for TMEM8B Gene

35,814,451 bp from pter
35,854,847 bp from pter
40,397 bases
Plus strand

Genomic View for TMEM8B Gene

Genes around TMEM8B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM8B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM8B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM8B Gene

Proteins for TMEM8B Gene

  • Protein details for TMEM8B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 8B
    Protein Accession:
    Secondary Accessions:
    • B3KQF3
    • O75539
    • Q49AB1
    • Q4KMX5
    • Q5TCW5
    • Q9HBY2
    • Q9P0U7

    Protein attributes for TMEM8B Gene

    472 amino acids
    Molecular mass:
    51941 Da
    Quaternary structure:
    • Isoform 2 (via its cytoplasmic part) interacts with EZR.
    • Sequence=AAC28644.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAF34820.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAF34820.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305};

    Alternative splice isoforms for TMEM8B Gene


neXtProt entry for TMEM8B Gene

Post-translational modifications for TMEM8B Gene

No data available for DME Specific Peptides for TMEM8B Gene

Domains & Families for TMEM8B Gene

Protein Domains for TMEM8B Gene


Suggested Antigen Peptide Sequences for TMEM8B Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TMEM8 family.
  • Belongs to the TMEM8 family.
genes like me logo Genes that share domains with TMEM8B: view

No data available for Gene Families for TMEM8B Gene

Function for TMEM8B Gene

Molecular function for TMEM8B Gene

UniProtKB/Swiss-Prot Function:
May function as a regulator of the EGFR pathway. Probable tumor suppressor which may function in cell growth, proliferation and adhesion.
UniProtKB/Swiss-Prot Induction:
Isoform 2 is down-regulated in nasopharyngeal carcinoma cells.

Gene Ontology (GO) - Molecular Function for TMEM8B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15498789
genes like me logo Genes that share ontologies with TMEM8B: view
genes like me logo Genes that share phenotypes with TMEM8B: view

Animal Model Products

CRISPR Products

miRNA for TMEM8B Gene

miRTarBase miRNAs that target TMEM8B

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM8B Gene

Localization for TMEM8B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM8B Gene

Isoform 2: Cell membrane; Multi-pass membrane protein. Cytoplasm. Nucleus. Mitochondrion. Endoplasmic reticulum. Note=Also detected in mitochondrion and endoplasmic reticulum (PubMed:17641538).

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM8B gene
Compartment Confidence
plasma membrane 5
nucleus 4
mitochondrion 3
endoplasmic reticulum 3

Gene Ontology (GO) - Cellular Components for TMEM8B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005886 plasma membrane IEA,IDA 15498789
genes like me logo Genes that share ontologies with TMEM8B: view

Pathways & Interactions for TMEM8B Gene

SuperPathways for TMEM8B Gene

No Data Available

Interacting Proteins for TMEM8B Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000367227 A6NDV4-TMM8B_HUMAN for TMEM8B Gene via STRING IID

Gene Ontology (GO) - Biological Process for TMEM8B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0007160 cell-matrix adhesion IMP 15498789
GO:0007346 regulation of mitotic cell cycle TAS 15498789
GO:0040008 regulation of growth IEA --
genes like me logo Genes that share ontologies with TMEM8B: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM8B Gene

Drugs & Compounds for TMEM8B Gene

No Compound Related Data Available

Transcripts for TMEM8B Gene

Unigene Clusters for TMEM8B Gene

Transmembrane protein 8B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM8B Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^
SP3: - - - - - - - - - - - -
SP4: - - - - -
SP5: -
SP6: - - - - - - - - -
SP7: - - - - - - - - - -
SP8: - - - -
SP9: - - -
SP10: - - - -
SP11: -
SP13: - - - - - - - - -
SP14: - - - - - - - - - -

ExUns: 13a · 13b ^ 14 ^ 15 ^ 16a · 16b
SP1: -
SP2: -
SP6: -

Relevant External Links for TMEM8B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM8B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM8B Gene

NURSA nuclear receptor signaling pathways regulating expression of TMEM8B Gene:


SOURCE GeneReport for Unigene cluster for TMEM8B Gene:


Evidence on tissue expression from TISSUES for TMEM8B Gene

  • Nervous system(4.3)
  • Intestine(2)
genes like me logo Genes that share expression patterns with TMEM8B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM8B Gene

Orthologs for TMEM8B Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM8B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMEM8B 34 35
  • 99.65 (n)
(Canis familiaris)
Mammalia TMEM8B 34 35
  • 93.08 (n)
(Bos Taurus)
Mammalia TMEM8B 34 35
  • 91.38 (n)
(Rattus norvegicus)
Mammalia Tmem8b 34
  • 89.97 (n)
(Mus musculus)
Mammalia Tmem8b 34 16 35
  • 89.83 (n)
(Monodelphis domestica)
Mammalia TMEM8B 35
  • 47 (a)
(Ornithorhynchus anatinus)
Mammalia TMEM8B 35
  • 45 (a)
(Gallus gallus)
Aves TMEM8B 34 35
  • 75 (n)
(Anolis carolinensis)
Reptilia TMEM8B 35
  • 76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem8b 34
  • 69.66 (n)
(Danio rerio)
Actinopterygii si:dkey-84j12.1 35 34
  • 69.21 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG13654 35
  • 14 (a)
Species where no ortholog for TMEM8B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM8B Gene

Gene Tree for TMEM8B (if available)
Gene Tree for TMEM8B (if available)

Paralogs for TMEM8B Gene

Paralogs for TMEM8B Gene

(2) SIMAP similar genes for TMEM8B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TMEM8B: view

Variants for TMEM8B Gene

Sequence variations from dbSNP and Humsavar for TMEM8B Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1000307321 -- 35,850,815(+) TTCTT(C/T)CTATA intron-variant
rs1000332561 -- 35,844,687(+) CGTAG(A/G)CCCTG intron-variant
rs1000462952 -- 35,857,492(+) GGGTG(C/T)GGCAG utr-variant-3-prime
rs1000469125 -- 35,861,324(+) GTGTC(C/T)TCCCG nc-transcript-variant, utr-variant-3-prime
rs1000480699 -- 35,833,069(+) CACCT(A/T)TGTAG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TMEM8B Gene

Variant ID Type Subtype PubMed ID
nsv1125318 OTHER inversion 24896259
nsv831546 CNV loss 17160897

Variation tolerance for TMEM8B Gene

Residual Variation Intolerance Score: 29.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.52; 44.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM8B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM8B Gene

Disorders for TMEM8B Gene

MalaCards: The human disease database

(2) MalaCards diseases for TMEM8B Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
nasopharyngeal carcinoma
  • nasopharynx carcinoma
pharynx cancer
  • pharyngeal cancer
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TMEM8B

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TMEM8B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TMEM8B Gene

Publications for TMEM8B Gene

  1. The expression of ezrin in NPC and its interaction with NGX6, a novel candidate suppressor. (PMID: 17270023) Peng S.-P. … Li G.-Y. (Cancer Sci. 2007) 3 4 64
  2. The role of NGX6 and its deletion mutants in the proliferation, adhesion and migration of nasopharyngeal carcinoma 5-8F cells. (PMID: 17641538) Peng S.P. … Li G.-Y. (Oncology 2006) 3 4 64
  3. Role of a novel EGF-like domain-containing gene NGX6 in cell adhesion modulation in nasopharyngeal carcinoma cells. (PMID: 15498789) Ma J. … Li G.-Y. (Carcinogenesis 2005) 3 4 64
  4. NGX6 gene inhibits cell proliferation and plays a negative role in EGFR pathway in nasopharyngeal carcinoma cells. (PMID: 15723283) Wang L.-L. … Li G.-Y. (J. Cell. Biochem. 2005) 3 4 64
  5. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4 64

Products for TMEM8B Gene

Sources for TMEM8B Gene

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