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Aliases for TMEM8A Gene

Aliases for TMEM8A Gene

  • Transmembrane Protein 8A 2 3 5
  • Transmembrane Protein 6 2 3 4
  • Transmembrane Protein 8 (Five Membrane-Spanning Domains) 2 3
  • TMEM6 3 4
  • TMEM8 3 4
  • Five-Span Transmembrane Protein M83 3
  • Transmembrane Protein 8 4
  • Protein M83 4
  • M83 3

External Ids for TMEM8A Gene

Previous HGNC Symbols for TMEM8A Gene

  • TMEM6
  • TMEM8

Summaries for TMEM8A Gene

GeneCards Summary for TMEM8A Gene

TMEM8A (Transmembrane Protein 8A) is a Protein Coding gene. An important paralog of this gene is TMEM8B.

UniProtKB/Swiss-Prot for TMEM8A Gene

  • May be a cell surface adhesion molecule. May be involved in the maintenance of the resting T-cell state.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM8A Gene

Genomics for TMEM8A Gene

Genomic Location for TMEM8A Gene

370,773 bp from pter
387,113 bp from pter
16,341 bases
Minus strand

Genomic View for TMEM8A Gene

Genes around TMEM8A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM8A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM8A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM8A Gene

No data available for Regulatory Elements for TMEM8A Gene

Proteins for TMEM8A Gene

  • Protein details for TMEM8A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 8A
    Protein Accession:
    Secondary Accessions:
    • D3DU49
    • Q4TT35
    • Q8WU24
    • Q96S25
    • Q9BR03
    • Q9BT97
    • Q9H7B9

    Protein attributes for TMEM8A Gene

    771 amino acids
    Molecular mass:
    84761 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB14975.1; Type=Erroneous termination; Positions=750; Note=Translated as Ser.; Evidence={ECO:0000305};

neXtProt entry for TMEM8A Gene

Proteomics data for TMEM8A Gene at MOPED

Post-translational modifications for TMEM8A Gene

Other Protein References for TMEM8A Gene

No data available for DME Specific Peptides for TMEM8A Gene

Domains & Families for TMEM8A Gene

Protein Domains for TMEM8A Gene


Graphical View of Domain Structure for InterPro Entry



  • Contains 1 EGF-like domain.
  • Belongs to the TMEM8 family.
  • Contains 1 EGF-like domain.
  • Belongs to the TMEM8 family.
genes like me logo Genes that share domains with TMEM8A: view

No data available for Gene Families for TMEM8A Gene

Function for TMEM8A Gene

Molecular function for TMEM8A Gene

UniProtKB/Swiss-Prot Function:
May be a cell surface adhesion molecule. May be involved in the maintenance of the resting T-cell state.
UniProtKB/Swiss-Prot Induction:
Repressed during activation of CD4+ and CD8+ T-lymphocytes.

Gene Ontology (GO) - Molecular Function for TMEM8A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with TMEM8A: view
genes like me logo Genes that share phenotypes with TMEM8A: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TMEM8A

CRISPR Products

miRNA for TMEM8A Gene

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM8A Gene

Localization for TMEM8A Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM8A Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for TMEM8A Gene COMPARTMENTS Subcellular localization image for TMEM8A gene
Compartment Confidence
extracellular 5
lysosome 5
plasma membrane 5
vacuole 5
nucleus 2

Gene Ontology (GO) - Cellular Components for TMEM8A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IBA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with TMEM8A: view

Pathways & Interactions for TMEM8A Gene

SuperPathways for TMEM8A Gene

No Data Available

Interacting Proteins for TMEM8A Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000401338 Q9HCN3-TMM8A_HUMAN for TMEM8A Gene via STRING UniProtKB

Gene Ontology (GO) - Biological Process for TMEM8A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
genes like me logo Genes that share ontologies with TMEM8A: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM8A Gene

Drugs & Compounds for TMEM8A Gene

No Compound Related Data Available

Transcripts for TMEM8A Gene

Unigene Clusters for TMEM8A Gene

Transmembrane protein 8A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM8A Gene

No ASD Table

Relevant External Links for TMEM8A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM8A Gene

mRNA expression in normal human tissues for TMEM8A Gene

mRNA differential expression in normal tissues according to GTEx for TMEM8A Gene

This gene is overexpressed in Whole Blood (x6.3).

Protein differential expression in normal tissues from HIPED for TMEM8A Gene

This gene is overexpressed in Placenta (37.5), Testis (23.3), and Spleen (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TMEM8A Gene

SOURCE GeneReport for Unigene cluster for TMEM8A Gene Hs.288940

mRNA Expression by UniProt/SwissProt for TMEM8A Gene

Tissue specificity: Expressed in pancreas, placenta, spleen, liver, kidney, bone marrow, peripheral blood leukocytes and tonsil.
genes like me logo Genes that share expression patterns with TMEM8A: view

Protein tissue co-expression partners for TMEM8A Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for TMEM8A Gene

Orthologs for TMEM8A Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM8A Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TMEM8A 35
  • 81.88 (n)
  • 73.96 (a)
TMEM8 36
  • 73 (a)
(Canis familiaris)
Mammalia TMEM8A 35
  • 81.3 (n)
  • 75.54 (a)
  • 74 (a)
(Mus musculus)
Mammalia Tmem8 35
  • 79.89 (n)
  • 76.07 (a)
Tmem8 16
Tmem8 36
  • 75 (a)
(Pan troglodytes)
Mammalia TMEM8A 35
  • 98.96 (n)
  • 98.96 (a)
  • 97 (a)
(Rattus norvegicus)
Mammalia Tmem8a 35
  • 79.71 (n)
  • 76.07 (a)
(Monodelphis domestica)
Mammalia TMEM8A 36
  • 61 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 56 (a)
(Gallus gallus)
Aves -- 36
  • 55 (a)
-- 36
  • 55 (a)
(Anolis carolinensis)
Reptilia TMEM8A 36
  • 51 (a)
(Danio rerio)
Actinopterygii tmem8a 36
  • 43 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG13654 36
  • 17 (a)
Species with no ortholog for TMEM8A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM8A Gene

Gene Tree for TMEM8A (if available)
Gene Tree for TMEM8A (if available)

Paralogs for TMEM8A Gene

Paralogs for TMEM8A Gene

(2) SIMAP similar genes for TMEM8A Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TMEM8A: view

Variants for TMEM8A Gene

Sequence variations from dbSNP and Humsavar for TMEM8A Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs11248931 - 377,479(+) CGGTG(C/T)GGTGC reference, missense
rs2071915 - 376,432(+) CTGGA(C/T)GGTCA reference, missense
rs3743887 - 374,277(+) TCGCC(A/G/T)CACTG reference, missense
rs374847 -- 378,152(+) CACCC(G/T)GACTG intron-variant
rs439250 -- 378,415(-) ggtgg(C/G)gatgg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM8A Gene

Variant ID Type Subtype PubMed ID
esv2422427 CNV Duplication 17116639
nsv904652 CNV Loss 21882294
dgv32n68 CNV Loss 17160897
dgv2466n71 CNV Loss 21882294
dgv2469n71 CNV Loss 21882294
dgv2472n71 CNV Loss 21882294
dgv2473n71 CNV Loss 21882294
nsv904699 CNV Loss 21882294
nsv904700 CNV Loss 21882294
nsv904707 CNV Loss 21882294
nsv517471 CNV Loss 19592680
nsv827478 CNV Gain 20364138
dgv2474n71 CNV Loss 21882294
nsv904709 CNV Gain+Loss 21882294
nsv904711 CNV Loss 21882294
esv33562 CNV Loss 17666407

Variation tolerance for TMEM8A Gene

Residual Variation Intolerance Score: 83.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.11; 69.15% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM8A Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM8A Gene

Disorders for TMEM8A Gene

Relevant External Links for TMEM8A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TMEM8A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM8A Gene

Publications for TMEM8A Gene

  1. Molecular cloning and chromosomal mapping of a novel five-span transmembrane protein gene, M83. (PMID: 11006113) Motohashi T. … Nakauchi H. (Biochem. Biophys. Res. Commun. 2000) 2 3 4 23 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S. … Drake R.R. (Proteomics 2013) 3
  5. Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways. (PMID: 21752829) Palmieri M. … Ballabio A. (Hum. Mol. Genet. 2011) 3

Products for TMEM8A Gene

Sources for TMEM8A Gene

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