TMEM8A Gene
protein-coding GIFtS: 46
GCID: GC16M000360
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transmembrane protein 8A(Previous names: transmembrane protein 6, transmembrane protein 8 (five...)
(Previous symbols: TMEM6, TMEM8)
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Aliases
for TMEM8A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Transmembrane Protein 8A1 2 | | Transmembrane Protein 8 (Five Membrane-Spanning Domains)1 2 | | Transmembrane Protein 61 2 3 | | Five-Span Transmembrane Protein M832 | | TMEM61 2 3 | | Protein M833 | | TMEM81 2 3 | | Transmembrane Protein 83 | | M831 2 | | |
Export aliases for TMEM8A gene to outside databases |
Summaries
for TMEM8A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: TMM8A_HUMAN, Q9HCN3Function: May be a cell surface adhesion molecule. May be involved in the maintenance of the resting T-cell state
|
Genomic Views
for TMEM8A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010393.16
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for TMEM8A
Other transcription factors
Search SABiosciences Chromatin IP Primers for TMEM8A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM8A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16p13.3 Ensembl cytogenetic band: 16p13.3 HGNC cytogenetic band: 16p13.3TMEM8A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16M000360: view genomic region
(about GC identifiers)
Start:
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420,773 bp from pter |
End:
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437,113 bp from pter |
Size:
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16,341 bases |
Orientation:
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minus strand |
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Proteins
for TMEM8A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TMM8A_HUMAN, Q9HCN3 (See
protein sequence)Recommended Name: Transmembrane protein 8A precursor Size: 771 amino acids; 84761 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Sequence caution: Sequence=BAB14975.1; Type=Erroneous termination; Positions=750; Note=Translated as Ser;
Secondary accessions: D3DU49 Q4TT35 Q8WU24 Q96S25 Q9BR03 Q9BT97 Q9H7B9Explore the universe of human proteins at neXtProt for TMEM8A: NX_Q9HCN3
Post-translational modifications:
Glycosylated1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9HCN3
TMEM8A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_067082.2
ENSEMBL proteins: ENSP00000401338 ENSP00000397620 ENSP00000250930 ENSP00000401931 ENSP00000410987
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table
TMEM8A for ontologies About GeneDecksing
TMEM8A Antibody Products:
Assay Products for TMEM8A: |
Protein
Domains /
Families
for TMEM8A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TMEM8A for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9HCN3ProtoNet protein and cluster: Q9HCN3 1 Blocks protein family: IPB006210 Type I EGF
UniProtKB/Swiss-Prot: TMM8A_HUMAN, Q9HCN3Similarity: Belongs to the TMEM8 familySimilarity: Contains 1 EGF-like domain |
Function
for TMEM8A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TMM8A_HUMAN, Q9HCN3Function: May be a cell surface adhesion molecule. May be involved in the maintenance of the resting T-cell stateInduction: Repressed during activation of CD4+ and CD8+ T-lymphocytes
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM8A (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM8A
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for TMEM8A | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM8A |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM8A |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
ND | -- |
TMEM8A for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for TMEM8A:
|
Pathways & Interactions
for TMEM8A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMEM8A
STRING Interaction
Network Preview (showing 5 interactants - click image to see 8)
5/8 Interacting proteins for TMEM8A (ENSP000004013384) via UniProtKB, MINT, STRING, and/or I2D (see all 8)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007155 | cell adhesion |
IEA | -- | | GO:0008150 | biological_process |
ND | -- |
TMEM8A for ontologies About GeneDecksing
|
Drugs & Compounds
for TMEM8A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TMEM8A
Search CenterWatch for drugs/clinical trials and news about TMEM8A / TMM8A
|
Transcripts
for TMEM8A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TMEM8A gene: NM_021259.2 Unigene Cluster for TMEM8A: Transmembrane protein 8A Hs.288940 [show with all ESTs]Unigene Representative Sequence: NM_0212598 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000431232(uc002cgu.4 uc002cgv.4) ENST00000424078 ENST00000250930
ENST00000448854 ENST00000467452 ENST00000475348 ENST00000427313 ENST00000476735
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM8A (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM8A
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TMEM8A (NM_021259) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMEM8A | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM8A |
Additional cDNA sequence: AB045292.1 AK024725.1 AK091823.1 BC004276.1 BC021557.1 BC146939.1 BC146942.1 13 DOTS entries: DT.85105465 DT.97773134 DT.100776561 DT.100665804 DT.120692906 DT.95079656 DT.120692864 DT.120692915 DT.120692918 DT.120692919 DT.95079654 DT.95288308 DT.100016928 24/264 AceView cDNA sequences (see all 264): CA488354 BM831902 BQ008532 BM976061 BG824274 BU726867 AI571064 BM854399 BG824768 AI628804 BU177676 AI678371 BQ954173 AW297740 BM978036 BI052866 BG283001 AI767451 AW003475 BG747081 AI652943 CR590299 BM467735 AA528201
GeneLoc Exon Structure
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Expression
for TMEM8A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TMEM8A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATGACTAGCG
About this image
See TMEM8A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TMEM8A
SOURCE GeneReport for Unigene cluster: Hs.288940
UniProtKB/Swiss-Prot: TMM8A_HUMAN, Q9HCN3Tissue specificity: Expressed in pancreas, placenta, spleen, liver, kidney, bone marrow, peripheral blood leukocytesand tonsil
SABiosciences Custom PCR Arrays for TMEM8A
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM8A
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TMEM8A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM8A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM8A | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM8A |
Orthologs
for TMEM8A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for TMEM8A gene from 4/14 species (see all 14) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
TMEM8A6 |
Uncharacterized protein |
58(a) |
1 ↔ 1 |
14(12744994-12757648) |
lizard
(Anolis carolinensis) |
Reptilia |
TMEM8A6 |
-- |
52(a) |
1 ↔ 1 |
GL344563.1(578-3490) |
zebrafish
(Danio rerio) |
Actinopterygii |
tmem8a6 |
transmembrane protein 8A |
43(a) |
1 ↔ 1 |
1(8992462-9017000) |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG136546 |
-- |
17(a) |
1 → many |
3R(21025540-21039371) |
ENSEMBL Gene Tree for TMEM8A (if available)
TreeFam Gene Tree for TMEM8A (if available) |
Paralogs
for TMEM8A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TMEM8A gene
- TMEM8B2 TMEM8C2
2 SIMAP similar genes for TMEM8A using alignment to 5 protein entries: TMM8A_HUMAN (see all proteins):TMEM8B TMEM8C
TMEM8A for paralogs About GeneDecksing
|
Genomic Variants
for TMEM8A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TMEM8A (420773 - 437113 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 7 variations for TMEM8A
7 CNVs: 49710 49711 3987 7109 49712 4912 5329
Human Gene Mutation Database (HGMD): TMEM8A
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMEM8A |
|
Disorders
/ Diseases
for TMEM8A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TMEM8A for disorders About GeneDecksing
1  disease for TMEM8A: About MalaCardstonsillitis
Export disorders for TMEM8A gene to outside databases
|
Publications
for TMEM8A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TMEM8A gene integrated from 9 sources:
(articles sorted by number of sources associating them with TMEM8A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Molecular cloning and chromosomal mapping of a novel five-span transmembrane protein gene, M83. (PubMed id 11006113)1, 2, 3, 9 Motohashi T.... Nakauchi H. (2000)
- The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)1, 2 Martin J.... Pennacchio L.A. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. (PubMed id 11157797)1, 2 Daniels R.J....Higgs D.R. (2001)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for TMEM8A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TMEM8A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TMEM8A gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TMEM8A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TMEM8A | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TMEM8A gene:
Search GeneIP for patents involving TMEM8A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TMEM8A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TMEM8A | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMEM8A | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM8A | | | OriGene Protein Over-expression Lysate for TMEM8A | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TMEM8A | | OriGene 3'-UTR Clone for TMEM8A | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM8A | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM8A | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TMEM8A | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMEM8A | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM8A | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMEM8A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM8A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM8A |
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 | | | TMEM8A Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM8A |
|  |  |  | | | | Search ThermoFisher Antibodies for TMEM8A |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM8A |
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