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Aliases for TMEM8A Gene

Aliases for TMEM8A Gene

  • Transmembrane Protein 8A 2 3 5
  • Transmembrane Protein 6 2 3 4
  • Transmembrane Protein 8 (Five Membrane-Spanning Domains) 2 3
  • TMEM6 3 4
  • TMEM8 3 4
  • Five-Span Transmembrane Protein M83 3
  • Transmembrane Protein 8 4
  • Protein M83 4
  • M83 3

External Ids for TMEM8A Gene

Previous HGNC Symbols for TMEM8A Gene

  • TMEM6
  • TMEM8

Summaries for TMEM8A Gene

GeneCards Summary for TMEM8A Gene

TMEM8A (Transmembrane Protein 8A) is a Protein Coding gene. An important paralog of this gene is TMEM8B.

UniProtKB/Swiss-Prot for TMEM8A Gene

  • May be a cell surface adhesion molecule. May be involved in the maintenance of the resting T-cell state.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM8A Gene

Genomics for TMEM8A Gene

Regulatory Elements for TMEM8A Gene

Enhancers for TMEM8A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F000329 1.6 FANTOM5 Ensembl ENCODE 31.6 +55.7 55673 3.1 PKNOX1 ARID4B SIN3A DMAP1 ZNF48 SLC30A9 GLIS2 ZNF263 SP3 MXD4 TMEM8A NHLRC4 MRPL28 ARHGDIG NME4 AXIN1 HAGHL PIR38678 GC16P000365
GH16F000358 1.3 Ensembl ENCODE 35.6 +25.1 25066 6.2 PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF48 ZNF2 ZNF143 DEK TMEM8A MRPL28 ARHGDIG AXIN1
GH16F000369 1 ENCODE 45.8 +16.6 16599 2.3 HDGF ATF1 PKNOX1 ZFP64 ARID4B SIN3A GLIS2 ELK1 ZNF143 FOS TMEM8A MRPL28 AXIN1
GH16F000333 1.5 FANTOM5 Ensembl ENCODE 30.4 +49.7 49672 7.3 ATF1 PKNOX1 ARID4B DMAP1 ZNF2 GLIS2 REST SMARCA4 ZSCAN16 PBX2 TMEM8A MRPL28 ARHGDIG RHBDF1 PDIA2 PIR38678 GC16P000365
GH16F000378 1 ENCODE 42.4 +5.4 5374 6.1 PKNOX1 ZFP64 ARID4B SIN3A DMAP1 ZNF48 ETS1 SLC30A9 ZNF121 GLIS2 TMEM8A MRPL28 ENSG00000228779 LOC100134368
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM8A on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM8A Gene

Chromosome:
16
Start:
370,773 bp from pter
End:
387,113 bp from pter
Size:
16,341 bases
Orientation:
Minus strand

Genomic View for TMEM8A Gene

Genes around TMEM8A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM8A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM8A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM8A Gene

Proteins for TMEM8A Gene

  • Protein details for TMEM8A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HCN3-TMM8A_HUMAN
    Recommended name:
    Transmembrane protein 8A
    Protein Accession:
    Q9HCN3
    Secondary Accessions:
    • D3DU49
    • Q4TT35
    • Q8WU24
    • Q96S25
    • Q9BR03
    • Q9BT97
    • Q9H7B9

    Protein attributes for TMEM8A Gene

    Size:
    771 amino acids
    Molecular mass:
    84761 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB14975.1; Type=Erroneous termination; Positions=750; Note=Translated as Ser.; Evidence={ECO:0000305};

neXtProt entry for TMEM8A Gene

Post-translational modifications for TMEM8A Gene

Other Protein References for TMEM8A Gene

No data available for DME Specific Peptides for TMEM8A Gene

Domains & Families for TMEM8A Gene

Protein Domains for TMEM8A Gene

Graphical View of Domain Structure for InterPro Entry

Q9HCN3

UniProtKB/Swiss-Prot:

TMM8A_HUMAN :
  • Contains 1 EGF-like domain.
  • Belongs to the TMEM8 family.
Domain:
  • Contains 1 EGF-like domain.
Family:
  • Belongs to the TMEM8 family.
genes like me logo Genes that share domains with TMEM8A: view

No data available for Gene Families for TMEM8A Gene

Function for TMEM8A Gene

Molecular function for TMEM8A Gene

UniProtKB/Swiss-Prot Function:
May be a cell surface adhesion molecule. May be involved in the maintenance of the resting T-cell state.
UniProtKB/Swiss-Prot Induction:
Repressed during activation of CD4+ and CD8+ T-lymphocytes.

Gene Ontology (GO) - Molecular Function for TMEM8A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TMEM8A: view
genes like me logo Genes that share phenotypes with TMEM8A: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TMEM8A

miRNA for TMEM8A Gene

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM8A Gene

Localization for TMEM8A Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM8A Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM8A gene
Compartment Confidence
plasma membrane 5
extracellular 5
lysosome 5
nucleus 2

Gene Ontology (GO) - Cellular Components for TMEM8A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005765 lysosomal membrane IDA 17897319
GO:0005886 plasma membrane IBA --
GO:0005887 integral component of plasma membrane NAS 11006113
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM8A: view

Pathways & Interactions for TMEM8A Gene

SuperPathways for TMEM8A Gene

No Data Available

Interacting Proteins for TMEM8A Gene

Gene Ontology (GO) - Biological Process for TMEM8A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with TMEM8A: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM8A Gene

Transcripts for TMEM8A Gene

Unigene Clusters for TMEM8A Gene

Transmembrane protein 8A:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM8A Gene

No ASD Table

Relevant External Links for TMEM8A Gene

GeneLoc Exon Structure for
TMEM8A
ECgene alternative splicing isoforms for
TMEM8A

Expression for TMEM8A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TMEM8A Gene

mRNA differential expression in normal tissues according to GTEx for TMEM8A Gene

This gene is overexpressed in Whole Blood (x6.3).

Protein differential expression in normal tissues from HIPED for TMEM8A Gene

This gene is overexpressed in Placenta (37.5), Testis (23.3), and Spleen (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TMEM8A Gene



Protein tissue co-expression partners for TMEM8A Gene

NURSA nuclear receptor signaling pathways regulating expression of TMEM8A Gene:

TMEM8A

SOURCE GeneReport for Unigene cluster for TMEM8A Gene:

Hs.288940

mRNA Expression by UniProt/SwissProt for TMEM8A Gene:

Q9HCN3-TMM8A_HUMAN
Tissue specificity: Expressed in pancreas, placenta, spleen, liver, kidney, bone marrow, peripheral blood leukocytes and tonsil.
genes like me logo Genes that share expression patterns with TMEM8A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for TMEM8A Gene

Orthologs for TMEM8A Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM8A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM8A 34 35
  • 98.96 (n)
cow
(Bos Taurus)
Mammalia TMEM8A 34
  • 81.88 (n)
TMEM8 35
  • 73 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM8A 34 35
  • 81.3 (n)
mouse
(Mus musculus)
Mammalia Tmem8 34 16 35
  • 79.89 (n)
rat
(Rattus norvegicus)
Mammalia Tmem8a 34
  • 79.71 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM8A 35
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 56 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 35
  • 55 (a)
OneToMany
-- 35
  • 55 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia TMEM8A 35
  • 51 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii tmem8a 35
  • 43 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG13654 35
  • 17 (a)
OneToMany
Species where no ortholog for TMEM8A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM8A Gene

ENSEMBL:
Gene Tree for TMEM8A (if available)
TreeFam:
Gene Tree for TMEM8A (if available)

Paralogs for TMEM8A Gene

Paralogs for TMEM8A Gene

(2) SIMAP similar genes for TMEM8A Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TMEM8A: view

Variants for TMEM8A Gene

Sequence variations from dbSNP and Humsavar for TMEM8A Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1046306 -- 372,131(-) AGCAT(C/T)TGGCA upstream-variant-2KB, reference, synonymous-codon
rs111247250 -- 376,874(+) AGCGT(C/G)CCCAG intron-variant
rs111359405 -- 373,231(+) CCCTG(A/G)CTGTG intron-variant
rs111359803 -- 375,936(+) AGCTA(C/T)CCCAC intron-variant
rs111512462 -- 378,371(+) CCGCA(A/C)TGCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM8A Gene

Variant ID Type Subtype PubMed ID
dgv32n68 CNV loss 17160897
dgv4809n54 CNV loss 21841781
nsv952897 CNV deletion 24416366
nsv827478 CNV gain 20364138
nsv570956 CNV gain 21841781
nsv570954 CNV loss 21841781
nsv517471 CNV loss 19592680
esv3637570 CNV gain 21293372
esv3637569 CNV loss 21293372
esv3637563 CNV gain 21293372
esv33562 CNV loss 17666407
esv2422427 CNV duplication 17116639
dgv4810n54 CNV loss 21841781

Variation tolerance for TMEM8A Gene

Residual Variation Intolerance Score: 83.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.11; 69.15% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM8A Gene

Human Gene Mutation Database (HGMD)
TMEM8A
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM8A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM8A Gene

Disorders for TMEM8A Gene

Relevant External Links for TMEM8A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM8A

No disorders were found for TMEM8A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM8A Gene

Publications for TMEM8A Gene

  1. Molecular cloning and chromosomal mapping of a novel five-span transmembrane protein gene, M83. (PMID: 11006113) Motohashi T. … Nakauchi H. (Biochem. Biophys. Res. Commun. 2000) 2 3 4 22 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J. … Pennacchio L.A. (Nature 2004) 3 4 64
  5. Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. (PMID: 11157797) Daniels R.J. … Higgs D.R. (Hum. Mol. Genet. 2001) 3 4 64

Products for TMEM8A Gene

Sources for TMEM8A Gene

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