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Aliases for TMEM89 Gene

Aliases for TMEM89 Gene

  • Transmembrane Protein 89 2 3

External Ids for TMEM89 Gene

Previous GeneCards Identifiers for TMEM89 Gene

  • GC03M048635
  • GC03M048658

Summaries for TMEM89 Gene

GeneCards Summary for TMEM89 Gene

TMEM89 is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM89 Gene

Genomics for TMEM89 Gene

Regulatory Elements for TMEM89 Gene

Genomic Location for TMEM89 Gene

48,620,759 bp from pter
48,621,855 bp from pter
1,097 bases
Minus strand

Genomic View for TMEM89 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM89 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM89 Gene

Proteins for TMEM89 Gene

  • Protein details for TMEM89 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 89
    Protein Accession:
    Secondary Accessions:

    Protein attributes for TMEM89 Gene

    159 amino acids
    Molecular mass:
    17572 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM89 Gene

Proteomics data for TMEM89 Gene at MOPED

Post-translational modifications for TMEM89 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM89 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM89 Gene

Domains for TMEM89 Gene

Protein Domains for TMEM89 Gene


Suggested Antigen Peptide Sequences for TMEM89 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM89: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TMEM89 Gene

Function for TMEM89 Gene

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM89

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TMEM89 Gene

Localization for TMEM89 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM89 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for TMEM89 Gene COMPARTMENTS Subcellular localization image for TMEM89 gene
Compartment Confidence
extracellular 2
plasma membrane 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for TMEM89 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM89: view

Pathways for TMEM89 Gene

SuperPathways for TMEM89 Gene

No Data Available

Interacting Proteins for TMEM89 Gene

Gene Ontology (GO) - Biological Process for TMEM89 Gene


No data available for Pathways by source for TMEM89 Gene

Transcripts for TMEM89 Gene

mRNA/cDNA for TMEM89 Gene

(6) Selected AceView cDNA sequences:
(2) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMEM89 Gene

Transmembrane protein 89:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM89

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM89 Gene

No ASD Table

Relevant External Links for TMEM89 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM89 Gene

mRNA expression in normal human tissues for TMEM89 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM89 Gene

This gene is overexpressed in Testis (35.3).

Protein differential expression in normal tissues for TMEM89 Gene

This gene is overexpressed in Testis (53.7) and Ovary (15.3).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for TMEM89 Gene

SOURCE GeneReport for Unigene cluster for TMEM89 Gene Hs.631922

genes like me logo Genes that share expressions with TMEM89: view

Expression partners for TMEM89 Gene

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for TMEM89 Gene

Orthologs for TMEM89 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TMEM89 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TMEM89 35
  • 75.89 (n)
  • 63.52 (a)
TMEM89 36
  • 64 (a)
(Canis familiaris)
Mammalia TMEM89 35
  • 80.29 (n)
  • 70.8 (a)
TMEM89 36
  • 62 (a)
(Mus musculus)
Mammalia Tmem89 35
  • 70.65 (n)
  • 57.23 (a)
Tmem89 16
Tmem89 36
  • 54 (a)
(Pan troglodytes)
Mammalia TMEM89 35
  • 99.58 (n)
  • 99.37 (a)
TMEM89 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Tmem89 35
  • 72.96 (n)
  • 59.12 (a)
(Monodelphis domestica)
Mammalia TMEM89 36
  • 29 (a)
Species with no ortholog for TMEM89:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TMEM89 Gene

Gene Tree for TMEM89 (if available)
Gene Tree for TMEM89 (if available)

Paralogs for TMEM89 Gene

No data available for Paralogs for TMEM89 Gene

Variants for TMEM89 Gene

Sequence variations from dbSNP and Humsavar for TMEM89 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs1264196 -- 48,623,190(-) cctcc(C/T)gggtt upstream-variant-2KB
rs3895736 -- 48,621,034(-) TCCTG(G/T)TCTCA intron-variant
rs9834639 - 48,621,576(+) TCCAG(G/T)GCCCA missense, reference
rs34156276 -- 48,622,961(+) ATCTC(-/A)AAAAA upstream-variant-2KB
rs56786096 -- 48,622,614(+) TGCCT(C/T)GGCCT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TMEM89 Gene

Variant ID Type Subtype PubMed ID
nsv523981 CNV Loss 19592680
nsv834685 CNV Loss 17160897
nsv876762 CNV Loss 21882294
nsv818138 CNV Gain 17921354

Relevant External Links for TMEM89 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM89 Gene

Disorders for TMEM89 Gene

Relevant External Links for TMEM89

Genetic Association Database (GAD)

No disorders were found for TMEM89 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for TMEM89 Gene

Publications for TMEM89 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  2. Proteomic characterization of the human sperm nucleus. (PMID: 21630459) de Mateo S. … Oliva R. (Proteomics 2011) 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4

Products for TMEM89 Gene

Sources for TMEM89 Gene

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