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Aliases for TMEM89 Gene

Aliases for TMEM89 Gene

  • Transmembrane Protein 89 2 3 5

External Ids for TMEM89 Gene

Previous GeneCards Identifiers for TMEM89 Gene

  • GC03M048635
  • GC03M048658

Summaries for TMEM89 Gene

GeneCards Summary for TMEM89 Gene

TMEM89 (Transmembrane Protein 89) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM89 Gene

Genomics for TMEM89 Gene

Regulatory Elements for TMEM89 Gene

Enhancers for TMEM89 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F049484 1.2 Ensembl ENCODE 15.7 -863.4 -863382 1.9 MLX ZFP64 ARID4B THRB ZNF48 RARA CREM THAP11 HMG20B ZNF680 AMT QRICH1 LOC105377080 ENSG00000230454 CCDC71 RHOA-IT1 TMEM89 WDR6 TMEM115 SEMA3F-AS1
GH03F049448 1.2 Ensembl ENCODE 15.7 -827.3 -827288 0.7 ELF3 ARID4B RAD21 RFX5 ZNF366 ZNF143 ZNF207 ETV6 DEK THAP11 QRICH1 LOC105377080 ENSG00000230454 CCDC71 RHOA-IT1 TMEM89 TMEM115 SEMA3F-AS1 NICN1 ENSG00000223343
GH03F049338 1.6 FANTOM5 ENCODE 10.8 -724.2 -724195 14.7 HDGF PKNOX1 CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 AMT QRICH1 BSN-AS1 IMPDH2 LOC105377080 DALRD3 RHOA C3orf84 PHF5EP WDR6
GH03F049356 1.1 ENCODE 15.7 -736.4 -736432 4.2 HDGF MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF143 AMT QRICH1 CCDC71 LAMB2 IMPDH2 RHOA-IT1 TMEM89 SEMA3F-AS1 FAM212A DAG1
GH03F048617 1 ENCODE 14.6 +2.9 2866 3.6 ATF1 MLX ARID4B SIN3A CBX5 ZNF207 ZNF143 SP5 PPARG KAT8 ENSG00000225399 TMEM89 QRICH1 NME6 RHOA-IT1 CCDC71 UQCRC1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM89 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM89 Gene

Chromosome:
3
Start:
48,620,759 bp from pter
End:
48,621,855 bp from pter
Size:
1,097 bases
Orientation:
Minus strand

Genomic View for TMEM89 Gene

Genes around TMEM89 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM89 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM89 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM89 Gene

Proteins for TMEM89 Gene

  • Protein details for TMEM89 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A2RUT3-TMM89_HUMAN
    Recommended name:
    Transmembrane protein 89
    Protein Accession:
    A2RUT3

    Protein attributes for TMEM89 Gene

    Size:
    159 amino acids
    Molecular mass:
    17572 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM89 Gene

Post-translational modifications for TMEM89 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM89 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM89 Gene

Domains & Families for TMEM89 Gene

Protein Domains for TMEM89 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM89 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM89: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TMEM89 Gene

Function for TMEM89 Gene

genes like me logo Genes that share phenotypes with TMEM89: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMEM89 Gene

Localization for TMEM89 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM89 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM89 gene
Compartment Confidence
nucleus 5
plasma membrane 2
extracellular 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for TMEM89 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM89: view

Pathways & Interactions for TMEM89 Gene

SuperPathways for TMEM89 Gene

No Data Available

Interacting Proteins for TMEM89 Gene

Selected Interacting proteins: A2RUT3-TMM89_HUMAN for TMEM89 Gene via IID

Symbol External ID(s) Details
C4A

Gene Ontology (GO) - Biological Process for TMEM89 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM89 Gene

Transcripts for TMEM89 Gene

mRNA/cDNA for TMEM89 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMEM89 Gene

Transmembrane protein 89:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM89 Gene

No ASD Table

Relevant External Links for TMEM89 Gene

GeneLoc Exon Structure for
TMEM89
ECgene alternative splicing isoforms for
TMEM89

Expression for TMEM89 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TMEM89 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM89 Gene

This gene is overexpressed in Testis (x35.3).

Protein differential expression in normal tissues from HIPED for TMEM89 Gene

This gene is overexpressed in Testis (53.7) and Ovary (15.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM89 Gene



Protein tissue co-expression partners for TMEM89 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TMEM89 Gene:

TMEM89

SOURCE GeneReport for Unigene cluster for TMEM89 Gene:

Hs.631922
genes like me logo Genes that share expression patterns with TMEM89: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for TMEM89 Gene

Orthologs for TMEM89 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TMEM89 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM89 34 35
  • 99.58 (n)
dog
(Canis familiaris)
Mammalia TMEM89 34 35
  • 80.29 (n)
cow
(Bos Taurus)
Mammalia TMEM89 34 35
  • 75.89 (n)
rat
(Rattus norvegicus)
Mammalia Tmem89 34
  • 72.96 (n)
mouse
(Mus musculus)
Mammalia Tmem89 34 16 35
  • 70.65 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM89 35
  • 29 (a)
OneToOne
Species where no ortholog for TMEM89 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TMEM89 Gene

ENSEMBL:
Gene Tree for TMEM89 (if available)
TreeFam:
Gene Tree for TMEM89 (if available)

Paralogs for TMEM89 Gene

No data available for Paralogs for TMEM89 Gene

Variants for TMEM89 Gene

Sequence variations from dbSNP and Humsavar for TMEM89 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs111660100 -- 48,623,525(+) GCCAA(A/G)ATCGT upstream-variant-2KB
rs112333368 -- 48,620,818(+) CTGTC(A/G)GGCAA downstream-variant-500B
rs114852143 -- 48,620,459(+) TATGT(A/G)TGTGC downstream-variant-500B
rs116625097 -- 48,621,316(+) ACAGG(A/G)ACAAT intron-variant
rs1264196 -- 48,623,190(-) cctcc(C/T)gggtt upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TMEM89 Gene

Variant ID Type Subtype PubMed ID
nsv523981 CNV loss 19592680
nsv590246 CNV loss 21841781
nsv818138 CNV gain 17921354
nsv834685 CNV loss 17160897
nsv954485 CNV deletion 24416366

Variation tolerance for TMEM89 Gene

Residual Variation Intolerance Score: 89.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.01; 68.43% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM89 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM89

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM89 Gene

Disorders for TMEM89 Gene

Relevant External Links for TMEM89

Genetic Association Database (GAD)
TMEM89
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM89

No disorders were found for TMEM89 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM89 Gene

Publications for TMEM89 Gene

  1. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  2. Proteomic characterization of the human sperm nucleus. (PMID: 21630459) de Mateo S. … Oliva R. (Proteomics 2011) 3 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for TMEM89 Gene

Sources for TMEM89 Gene

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