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Aliases for TMEM88B Gene

Aliases for TMEM88B Gene

  • Transmembrane Protein 88B 2 3 5

External Ids for TMEM88B Gene

Previous GeneCards Identifiers for TMEM88B Gene

  • GC01P001352
  • GC01P000634
  • GC01P001362

Summaries for TMEM88B Gene

GeneCards Summary for TMEM88B Gene

TMEM88B (Transmembrane Protein 88B) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM88B Gene

Genomics for TMEM88B Gene

Regulatory Elements for TMEM88B Gene

Enhancers for TMEM88B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G001840 1.3 FANTOM5 Ensembl ENCODE dbSUPER 9.2 +415.0 414980 2.1 CTCF PRDM6 ZSCAN5C ZSCAN4 SCRT2 TMEM88B LOC105378949 ATAD3C PRKCZ CALML6 GC01M001827 GC01P001820
GH01G001156 1.8 FANTOM5 Ensembl ENCODE dbSUPER 4.3 -267.7 -267694 4.4 HDGF ATF1 CREB3L1 ARID4B ZNF48 ZNF766 KDM4B SP5 ZHX2 ZNF592 LINC01786 TTLL10 LOC100287934 TTLL10-AS1 CICP3 UBE2J2 LINC00115 ENSG00000240731 ENSG00000272455 SLC35E2
GH01G001428 1.8 FANTOM5 ENCODE dbSUPER 2.3 +6.2 6176 8.2 HDGF FOXA2 AGO1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ATAD3C LINC01770 ANKRD65 ATAD3B VWA1 LOC100129381 RNF223 TMEM88B DVL1 NADK
GH01G001413 0.8 FANTOM5 1.7 -12.8 -12818 0.0 MXI1 KLF1 CREB3L1 BACH1 SIN3A RBBP5 ZNF335 ZNF207 ZBTB20 MAZ TNFRSF4 TNFRSF18 ANKRD65 ATAD3C TMEM88B GC01M001386 GC01P001410
GH01G001420 1.1 ENCODE 0.7 -3.9 -3944 3.0 HDGF FOXA2 MLX AGO1 ARID4B DMAP1 SLC30A9 ZNF766 KLF13 SP5 ANKRD65 ATAD3B TMEM88B
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM88B on UCSC Golden Path with GeneCards custom track

Promoters for TMEM88B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000000191 1572 601 ZNF146 KLF1 RB1 ZNF10 SP2 UBTF ZBTB7A ZFHX2 POLR2A EGR1

Genomic Location for TMEM88B Gene

Chromosome:
1
Start:
1,426,128 bp from pter
End:
1,427,787 bp from pter
Size:
1,660 bases
Orientation:
Plus strand

Genomic View for TMEM88B Gene

Genes around TMEM88B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM88B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM88B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM88B Gene

Proteins for TMEM88B Gene

  • Protein details for TMEM88B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NKF7-TM88B_HUMAN
    Recommended name:
    Transmembrane protein 88B
    Protein Accession:
    A6NKF7

    Protein attributes for TMEM88B Gene

    Size:
    163 amino acids
    Molecular mass:
    17097 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM88B Gene

Post-translational modifications for TMEM88B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM88B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM88B Gene

Domains & Families for TMEM88B Gene

Protein Domains for TMEM88B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM88B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NKF7

UniProtKB/Swiss-Prot:

TM88B_HUMAN :
  • Belongs to the TMEM88 family.
Family:
  • Belongs to the TMEM88 family.
genes like me logo Genes that share domains with TMEM88B: view

No data available for Gene Families for TMEM88B Gene

Function for TMEM88B Gene

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM88B Gene

Localization for TMEM88B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM88B Gene

Membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for TMEM88B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM88B: view

No data available for Subcellular locations from COMPARTMENTS for TMEM88B Gene

Pathways & Interactions for TMEM88B Gene

SuperPathways for TMEM88B Gene

No Data Available

Interacting Proteins for TMEM88B Gene

Gene Ontology (GO) - Biological Process for TMEM88B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM88B Gene

Drugs & Compounds for TMEM88B Gene

No Compound Related Data Available

Transcripts for TMEM88B Gene

mRNA/cDNA for TMEM88B Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
-
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMEM88B Gene

Transmembrane protein 88B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM88B Gene

No ASD Table

Relevant External Links for TMEM88B Gene

GeneLoc Exon Structure for
TMEM88B
ECgene alternative splicing isoforms for
TMEM88B

Expression for TMEM88B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM88B Gene

mRNA differential expression in normal tissues according to GTEx for TMEM88B Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x12.7), Brain - Substantia nigra (x8.1), Brain - Hippocampus (x5.4), Brain - Putamen (basal ganglia) (x4.3), Brain - Hypothalamus (x4.3), and Brain - Amygdala (x4.1).

NURSA nuclear receptor signaling pathways regulating expression of TMEM88B Gene:

TMEM88B

SOURCE GeneReport for Unigene cluster for TMEM88B Gene:

Hs.729765
genes like me logo Genes that share expression patterns with TMEM88B: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM88B Gene

Orthologs for TMEM88B Gene

This gene was present in the common ancestor of mammals.

Orthologs for TMEM88B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TMEM88B 34 35
  • 81.97 (n)
dog
(Canis familiaris)
Mammalia TMEM88B 34 35
  • 79.56 (n)
rat
(Rattus norvegicus)
Mammalia Tmem88b 34
  • 73.74 (n)
mouse
(Mus musculus)
Mammalia Tmem88b 34 16 35
  • 71.66 (n)
Species where no ortholog for TMEM88B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TMEM88B Gene

ENSEMBL:
Gene Tree for TMEM88B (if available)
TreeFam:
Gene Tree for TMEM88B (if available)

Paralogs for TMEM88B Gene

No data available for Paralogs for TMEM88B Gene

Variants for TMEM88B Gene

Sequence variations from dbSNP and Humsavar for TMEM88B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1001542388 -- 1,425,391(+) AACCA(A/G)GTATG upstream-variant-2KB
rs1002273370 -- 1,425,655(+) GAGAC(A/G)CAGGC upstream-variant-2KB
rs1002606914 -- 1,424,945(+) CAAAA(C/G/T)TAGCC upstream-variant-2KB
rs1002709347 -- 1,427,674(+) TCCGC(G/T)CCCGC reference, missense
rs1002721519 -- 1,424,770(+) GCTGA(C/T)GTGCA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TMEM88B Gene

Variant ID Type Subtype PubMed ID
dgv2n67 CNV gain 20364138
esv24333 CNV gain 19812545
esv2758913 CNV gain+loss 17122850
esv3389517 CNV duplication 20981092
esv3577672 CNV loss 25503493
nsv1009541 CNV gain 25217958
nsv1011818 CNV gain 25217958
nsv10161 CNV gain+loss 18304495
nsv1074978 CNV deletion 25765185
nsv1121740 CNV deletion 24896259
nsv1126168 CNV deletion 24896259
nsv482937 CNV loss 15286789
nsv545000 CNV loss 21841781
nsv950452 CNV deletion 24416366

Variation tolerance for TMEM88B Gene

Gene Damage Index Score: 3.71; 57.43% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM88B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM88B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM88B Gene

Disorders for TMEM88B Gene

Relevant External Links for TMEM88B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM88B

No disorders were found for TMEM88B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM88B Gene

Publications for TMEM88B Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64

Products for TMEM88B Gene

Sources for TMEM88B Gene

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