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Aliases for TMEM88 Gene

Aliases for TMEM88 Gene

  • Transmembrane Protein 88 2 3
  • TMEM88A 4

External Ids for TMEM88 Gene

Summaries for TMEM88 Gene

GeneCards Summary for TMEM88 Gene

TMEM88 is a Protein Coding gene.

UniProtKB/Swiss-Prot for TMEM88 Gene

  • Inhibits the Wnt/beta-catenin signaling pathway. Crucial for heart development and acts downstream of GATA factors in the pre-cardiac mesoderm to specify lineage commitment of cardiomyocyte development.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM88 Gene

Genomics for TMEM88 Gene

Genomic Location for TMEM88 Gene

7,854,863 bp from pter
7,856,099 bp from pter
1,237 bases
Plus strand

Genomic View for TMEM88 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM88 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM88 Gene

Regulatory Elements for TMEM88 Gene

Proteins for TMEM88 Gene

  • Protein details for TMEM88 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 88
    Protein Accession:
    Secondary Accessions:

    Protein attributes for TMEM88 Gene

    159 amino acids
    Molecular mass:
    17251 Da
    Quaternary structure:
    • Interacts (via C-terminus) with DVL1.

neXtProt entry for TMEM88 Gene

Proteomics data for TMEM88 Gene at MOPED

Post-translational modifications for TMEM88 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM88 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM88 Gene

Domains for TMEM88 Gene

Protein Domains for TMEM88 Gene



  • Belongs to the TMEM88 family.:
    • Q6PEY1
genes like me logo Genes that share domains with TMEM88: view

No data available for Gene Families for TMEM88 Gene

Function for TMEM88 Gene

Molecular function for TMEM88 Gene

UniProtKB/Swiss-Prot Function: Inhibits the Wnt/beta-catenin signaling pathway. Crucial for heart development and acts downstream of GATA factors in the pre-cardiac mesoderm to specify lineage commitment of cardiomyocyte development.

Gene Ontology (GO) - Molecular Function for TMEM88 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with TMEM88: view

Phenotypes for TMEM88 Gene

GenomeRNAi human phenotypes for TMEM88:
genes like me logo Genes that share phenotypes with TMEM88: view

miRNA for TMEM88 Gene

miRTarBase miRNAs that target TMEM88

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TMEM88 Gene

Localization for TMEM88 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM88 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for TMEM88 Gene COMPARTMENTS Subcellular localization image for TMEM88 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for TMEM88 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM88: view

Pathways for TMEM88 Gene

SuperPathways for TMEM88 Gene

No Data Available

Interacting Proteins for TMEM88 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000301599 for TMEM88 Gene via STRING

Gene Ontology (GO) - Biological Process for TMEM88 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organismal development IEA --
GO:0016055 Wnt signaling pathway IEA --
genes like me logo Genes that share ontologies with TMEM88: view

No data available for Pathways by source for TMEM88 Gene

Transcripts for TMEM88 Gene

mRNA/cDNA for TMEM88 Gene

Unigene Clusters for TMEM88 Gene

Transmembrane protein 88:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM88 Gene

No ASD Table

Relevant External Links for TMEM88 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM88 Gene

mRNA expression in normal human tissues for TMEM88 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM88 Gene

This gene is overexpressed in Heart - Left Ventricle (4.3).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for TMEM88 Gene

SOURCE GeneReport for Unigene cluster for TMEM88 Gene Hs.389669

genes like me logo Genes that share expressions with TMEM88: view

Orthologs for TMEM88 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM88 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMEM88 36
  • 99.79 (n)
  • 100 (a)
TMEM88 37
  • 100 (a)
(Bos Taurus)
Mammalia TMEM88 36
  • 90.57 (n)
  • 93.71 (a)
TMEM88 37
  • 94 (a)
(Canis familiaris)
Mammalia TMEM88 36
  • 88.26 (n)
  • 92.45 (a)
TMEM88 37
  • 92 (a)
(Mus musculus)
Mammalia Tmem88 36
  • 84.49 (n)
  • 88.68 (a)
Tmem88 16
Tmem88 37
  • 89 (a)
(Monodelphis domestica)
Mammalia TMEM88 37
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia TMEM88 37
  • 64 (a)
(Rattus norvegicus)
Mammalia Tmem88 36
  • 83.23 (n)
  • 85.53 (a)
(Gallus gallus)
Aves TMEM88 37
  • 37 (a)
(Anolis carolinensis)
Reptilia TMEM88 37
  • 53 (a)
(Danio rerio)
Actinopterygii tmem88a 37
  • 34 (a)
tmem88b 36
  • 60.61 (n)
  • 58.44 (a)
tmem88b 37
  • 32 (a)
Species with no ortholog for TMEM88:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM88 Gene

Gene Tree for TMEM88 (if available)
Gene Tree for TMEM88 (if available)

Paralogs for TMEM88 Gene

No data available for Paralogs for TMEM88 Gene

Variants for TMEM88 Gene

Sequence variations from dbSNP and Humsavar for TMEM88 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs8065467 -- 7,855,428(+) CCTGA(C/T)GCCTC intron-variant, reference, missense
rs61739615 -- 7,855,533(+) CCTCG(G/T)GCCGC missense, reference, intron-variant
rs76623612 -- 7,855,314(+) GTGTG(A/C)GTGTG intron-variant
rs138273202 -- 7,855,718(+) AATGA(C/T)CCTCG utr-variant-3-prime, intron-variant
rs139957500 -- 7,855,508(+) CCCTA(C/T)TGGTC reference, synonymous-codon, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM88 Gene

Variant ID Type Subtype PubMed ID
nsv833351 CNV Loss 17160897
nsv907653 CNV Loss 21882294
dgv510n67 CNV Gain 20364138

Relevant External Links for TMEM88 Gene

HapMap Linkage Disequilibrium report

Disorders for TMEM88 Gene

No disorders were found for TMEM88 Gene.

No data available for UniProtKB/Swiss-Prot for TMEM88 Gene

Publications for TMEM88 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. Identification of transmembrane protein 88 (TMEM88) as a dishevelled-binding protein. (PMID: 21044957) Lee H.J. … Zheng J.J. (J. Biol. Chem. 2010) 3 4
  3. Transmembrane protein 88: a Wnt regulatory protein that specifies cardiomyocyte development. (PMID: 23924634) Palpant N.J. … Murry C.E. (Development 2013) 3 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Increased miR-708 expression in NSCLC and its association with poor survival in lung adenocarcinoma from never smokers. (PMID: 22573352) Jang J.S. … Jen J. (Clin. Cancer Res. 2012) 3

Products for TMEM88 Gene

Sources for TMEM88 Gene

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