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Aliases for TMEM88 Gene

Aliases for TMEM88 Gene

  • Transmembrane Protein 88 2 3 5
  • TMEM88A 4

External Ids for TMEM88 Gene

Previous GeneCards Identifiers for TMEM88 Gene

  • GC17P007705
  • GC17P007758

Summaries for TMEM88 Gene

GeneCards Summary for TMEM88 Gene

TMEM88 (Transmembrane Protein 88) is a Protein Coding gene.

UniProtKB/Swiss-Prot for TMEM88 Gene

  • Inhibits the Wnt/beta-catenin signaling pathway. Crucial for heart development and acts downstream of GATA factors in the pre-cardiac mesoderm to specify lineage commitment of cardiomyocyte development.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM88 Gene

Genomics for TMEM88 Gene

Regulatory Elements for TMEM88 Gene

Enhancers for TMEM88 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G007882 1.7 FANTOM5 ENCODE dbSUPER 12.7 +31.7 31716 7.3 HDGF PKNOX1 FOXA2 AGO1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SENP3 KDM6B ZBTB4 LOC100996842 NEURL4 CYB5D1 TMEM88 KCNAB3 CNTROB TRAPPC1
GH17G007880 1.4 FANTOM5 Ensembl ENCODE dbSUPER 11.9 +26.6 26622 1.8 HDGF TBP NFIC ZNF366 ZNF701 MNT PRDM1 CNTROB SCARNA21 CYB5D1 SNORD10 SNORA48 DVL2 CTC1 ENSG00000262089 TMEM88 ENSG00000265749
GH17G007989 1.3 Ensembl ENCODE 11.1 +135.2 135242 1.7 HDGF ATF1 ZFP64 ARID4B SIN3A DMAP1 BRCA1 ZNF2 ZNF48 GLIS2 KCNAB3 ALOX15B TRAPPC1 CNTROB SCARNA21 CHD3 NAA38 CYB5D1 TMEM88 LOC284023
GH17G008055 1.3 Ensembl ENCODE 10.7 +202.0 202016 2.6 FOXA2 ATF1 MLX ARID4B SIN3A DMAP1 ZNF2 ZNF48 YY1 ZNF121 LOC107985075 NAA38 GUCY2D ALOX12B KCNAB3 TRAPPC1 CNTROB SCARNA21 CHD3 CYB5D1
GH17G007914 1.1 ENCODE 11.5 +61.0 61045 2.9 PKNOX1 ARNT CREB3L1 AGO1 SIN3A DMAP1 ZNF2 SLC30A9 ZNF766 ZNF143 KCNAB3 NAA38 CYB5D1 TMEM88 GUCY2D ALOX15B LOC284023 PIR53872
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM88 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM88 Gene

Chromosome:
17
Start:
7,854,896 bp from pter
End:
7,856,099 bp from pter
Size:
1,204 bases
Orientation:
Plus strand

Genomic View for TMEM88 Gene

Genes around TMEM88 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM88 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM88 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM88 Gene

Proteins for TMEM88 Gene

  • Protein details for TMEM88 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PEY1-TMM88_HUMAN
    Recommended name:
    Transmembrane protein 88
    Protein Accession:
    Q6PEY1

    Protein attributes for TMEM88 Gene

    Size:
    159 amino acids
    Molecular mass:
    17251 Da
    Quaternary structure:
    • Interacts (via C-terminus) with DVL1.

neXtProt entry for TMEM88 Gene

Post-translational modifications for TMEM88 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM88 Gene

No data available for DME Specific Peptides for TMEM88 Gene

Domains & Families for TMEM88 Gene

Protein Domains for TMEM88 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM88 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6PEY1

UniProtKB/Swiss-Prot:

TMM88_HUMAN :
  • Belongs to the TMEM88 family.
Family:
  • Belongs to the TMEM88 family.
genes like me logo Genes that share domains with TMEM88: view

No data available for Gene Families for TMEM88 Gene

Function for TMEM88 Gene

Molecular function for TMEM88 Gene

UniProtKB/Swiss-Prot Function:
Inhibits the Wnt/beta-catenin signaling pathway. Crucial for heart development and acts downstream of GATA factors in the pre-cardiac mesoderm to specify lineage commitment of cardiomyocyte development.

Gene Ontology (GO) - Molecular Function for TMEM88 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 26359454
GO:0030165 PDZ domain binding IEA,ISS --
genes like me logo Genes that share ontologies with TMEM88: view
genes like me logo Genes that share phenotypes with TMEM88: view

Animal Model Products

CRISPR Products

miRNA for TMEM88 Gene

miRTarBase miRNAs that target TMEM88

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM88 Gene

Localization for TMEM88 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM88 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM88 gene
Compartment Confidence
plasma membrane 5
cytosol 4

Gene Ontology (GO) - Cellular Components for TMEM88 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IDA 26359454
GO:0005886 plasma membrane IDA 21044957
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM88: view

Pathways & Interactions for TMEM88 Gene

SuperPathways for TMEM88 Gene

No Data Available

Interacting Proteins for TMEM88 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000301599%0d%0a9606.ENSP00000368169%0d%0a9606.ENSP00000316054%0d%0a9606.ENSP00000005340%0d%0a
Selected Interacting proteins: Q6PEY1-TMM88_HUMAN ENSP00000301599 for TMEM88 Gene via IID STRING

Gene Ontology (GO) - Biological Process for TMEM88 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0016055 Wnt signaling pathway IEA --
GO:0050821 protein stabilization IGI 26359454
GO:0072659 protein localization to plasma membrane IGI 21044957
GO:0090090 negative regulation of canonical Wnt signaling pathway IEA,IMP 21044957
genes like me logo Genes that share ontologies with TMEM88: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM88 Gene

Drugs & Compounds for TMEM88 Gene

No Compound Related Data Available

Transcripts for TMEM88 Gene

mRNA/cDNA for TMEM88 Gene

Unigene Clusters for TMEM88 Gene

Transmembrane protein 88:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM88 Gene

No ASD Table

Relevant External Links for TMEM88 Gene

GeneLoc Exon Structure for
TMEM88
ECgene alternative splicing isoforms for
TMEM88

Expression for TMEM88 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM88 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM88 Gene

This gene is overexpressed in Heart - Left Ventricle (x4.3).

Protein differential expression in normal tissues from HIPED for TMEM88 Gene

This gene is overexpressed in Heart (47.0) and Placenta (22.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TMEM88 Gene



Protein tissue co-expression partners for TMEM88 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TMEM88 Gene:

TMEM88

SOURCE GeneReport for Unigene cluster for TMEM88 Gene:

Hs.389669
genes like me logo Genes that share expression patterns with TMEM88: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM88 Gene

Orthologs for TMEM88 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM88 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM88 34 35
  • 99.79 (n)
cow
(Bos Taurus)
Mammalia TMEM88 34 35
  • 90.57 (n)
dog
(Canis familiaris)
Mammalia TMEM88 34 35
  • 88.26 (n)
mouse
(Mus musculus)
Mammalia Tmem88 34 16 35
  • 84.49 (n)
rat
(Rattus norvegicus)
Mammalia Tmem88 34
  • 83.23 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM88 35
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM88 35
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM88 35
  • 37 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM88 35
  • 53 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii tmem88b 34 35
  • 60.61 (n)
tmem88a 35
  • 34 (a)
OneToMany
Species where no ortholog for TMEM88 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM88 Gene

ENSEMBL:
Gene Tree for TMEM88 (if available)
TreeFam:
Gene Tree for TMEM88 (if available)

Paralogs for TMEM88 Gene

No data available for Paralogs for TMEM88 Gene

Variants for TMEM88 Gene

Sequence variations from dbSNP and Humsavar for TMEM88 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000018764 -- 7,854,003(+) GCTGT(A/G)ACCCC upstream-variant-2KB, utr-variant-3-prime
rs1000378794 -- 7,856,253(+) GACCT(C/G)AGAGA intron-variant, downstream-variant-500B, upstream-variant-2KB
rs1000749924 -- 7,856,110(+) TCTGC(A/G)AACAG intron-variant, downstream-variant-500B, upstream-variant-2KB
rs1001850162 -- 7,856,143(+) CCCCT(G/T)CCCTG intron-variant, downstream-variant-500B, upstream-variant-2KB
rs1002218829 -- 7,855,989(+) GACAA(A/C)AATCT upstream-variant-2KB, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TMEM88 Gene

Variant ID Type Subtype PubMed ID
dgv510n67 CNV gain 20364138
nsv1070804 CNV deletion 25765185
nsv833351 CNV loss 17160897

Variation tolerance for TMEM88 Gene

Residual Variation Intolerance Score: 82.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.16; 61.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM88 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM88

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM88 Gene

Disorders for TMEM88 Gene

Relevant External Links for TMEM88

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM88

No disorders were found for TMEM88 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM88 Gene

Publications for TMEM88 Gene

  1. Transmembrane protein 88: a Wnt regulatory protein that specifies cardiomyocyte development. (PMID: 23924634) Palpant N.J. … Murry C.E. (Development 2013) 3 4 64
  2. Identification of transmembrane protein 88 (TMEM88) as a dishevelled-binding protein. (PMID: 21044957) Lee H.J. … Zheng J.J. (J. Biol. Chem. 2010) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci. (PMID: 25429064) He M. … Qi L. (Hum. Mol. Genet. 2015) 3 64
  5. Cytosolic TMEM88 promotes triple-negative breast cancer by interacting with Dvl. (PMID: 26325443) Yu X. … Jin F. (Oncotarget 2015) 3 64

Products for TMEM88 Gene

Sources for TMEM88 Gene

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