TMEM87B Gene
protein-coding GIFtS: 46
GCID: GC02P112812
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transmembrane protein 87B
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Aliases
for TMEM87B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Transmembrane Protein 87B1 2 | | FLJ146811 |
Export aliases for TMEM87B gene to outside databasesPrevious GC identifers: GC02P112530 GC02P105326 |
Summaries
for TMEM87B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for TMEM87B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_022135.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TMEM87B gene promoter:
SRF HOXA3 SRF (504 AA) Meis-1b POU2F1 POU2F1a Meis-1a TGIF Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for TMEM87B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM87B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q13 Ensembl cytogenetic band: 2q13 HGNC cytogenetic band: 2q13TMEM87B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P112812: view genomic region
(about GC identifiers)
Start:
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112,812,800 bp from pter |
End:
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112,876,895 bp from pter |
Size:
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64,096 bases |
Orientation:
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plus strand |
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Proteins
for TMEM87B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TM87B_HUMAN, Q96K49 (See
protein sequence)Recommended Name: Transmembrane protein 87B precursor Size: 555 amino acids; 63536 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: A8K2M9 Q1RLN2 Q53R54Alternative splicing: 2 isoforms: Q96K49-1 Q96K49-2 Explore the universe of human proteins at neXtProt for TMEM87B: NX_Q96K49
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96K49
TMEM87B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_116213.1
ENSEMBL proteins: ENSP00000283206 ENSP00000393998 ENSP00000400100
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
TMEM87B for ontologies About GeneDecksing
TMEM87B Antibody Products:
Assay Products for TMEM87B: |
Protein
Domains /
Families
for TMEM87B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TMEM87B for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q96K49ProtoNet protein and cluster: Q96K49 UniProtKB/Swiss-Prot: TM87B_HUMAN, Q96K49Similarity: Belongs to the LU7TM family. TMEM87 subfamily |
Function
for TMEM87B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM87B (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM87B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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| |  | GenScript: all cDNA clones in your preferred vector: TMEM87B (NM_032824) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMEM87B | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM87B |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM87B |
|
Pathways & Interactions
for TMEM87B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMEM87B
3 Interacting proteins for TMEM87B (Q96K493) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for TMEM87B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TMEM87B
Search CenterWatch for drugs/clinical trials and news about TMEM87B / TM87B
|
Transcripts
for TMEM87B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TMEM87B gene: NM_032824.2 Unigene Cluster for TMEM87B: Transmembrane protein 87B Hs.656298 [show with all ESTs]Unigene Representative Sequence: NM_0328245 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000283206(uc010fkg.2 uc010fkh.2 uc002thm.2) ENST00000452614
ENST00000452029 ENST00000463427 ENST00000471632
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM87B (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM87B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TMEM87B (NM_032824) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMEM87B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM87B |
Additional cDNA sequence: AK027587.1 AK074243.1 AK290294.1 AY429534.1 AY429535.1 BC115373.1 4 DOTS entries: DT.95159749 DT.100812313 DT.91978276 DT.91962669 24/139 AceView cDNA sequences (see all 139): BF437100 AA455026 AI310805 CA437162 CD365869 AK074243 CB123783 BQ226125 AI832197 CF528785 AI539027 AA278279 CA454509 AI339881 CF454192 BU753848 AA700927 AA779956 BQ011966 BM313370 AY429535 AL041846 AA135900 AI094461
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for TMEM87B About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | - | | - | | | |
ECgene alternative splicing isoforms for TMEM87B
|
Expression
for TMEM87B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TMEM87B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAGAGACTTC
About this image
See TMEM87B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TMEM87B
SOURCE GeneReport for Unigene cluster: Hs.656298
SABiosciences Custom PCR Arrays for TMEM87B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM87B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TMEM87B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM87B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM87B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM87B |
Orthologs
for TMEM87B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for TMEM87B gene from 6/22 species (see all 22) About this table
ENSEMBL Gene Tree for TMEM87B (if available)
TreeFam Gene Tree for TMEM87B (if available) |
Paralogs
for TMEM87B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TMEM87B gene
- TMEM87A2
1 SIMAP similar gene for TMEM87B using alignment to 3 protein entries: TM87B_HUMAN (see all proteins):TMEM87A
TMEM87B for paralogs About GeneDecksing
|
Genomic Variants
for TMEM87B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TMEM87B (112812800 - 112876895 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for TMEM87B
1 CNV: 68128
3 Indels: 45838 26408 26407 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMEM87B |
|
Disorders
/ Diseases
for TMEM87B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TMEM87B for disorders About GeneDecksing
1  disease for TMEM87B: About MalaCardsmalaria
Export disorders for TMEM87B gene to outside databases
|
Publications
for TMEM87B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TMEM87B gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with TMEM87B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays. (PubMed id 14684825)1 Johnson J.M....Shoemaker D.D. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Expression of TMEM87B interacting with the human papillomavirus type 18 E6 oncogene in the Hela cDNA library by a yeast two-hybrid system. (PubMed id 18636207)9 Li S....Ma D. (2008)
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External Searches for TMEM87B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TMEM87B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TMEM87B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TMEM87B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TMEM87B | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TMEM87B gene:
Search GeneIP for patents involving TMEM87B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TMEM87B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TMEM87B | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMEM87B | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM87B | | | OriGene Protein Over-expression Lysate for TMEM87B | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TMEM87B | | OriGene 3'-UTR Clone for TMEM87B | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM87B | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM87B | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | | Search Tocris compounds for TMEM87B |
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 | | | TMEM87B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM87B |
|  |  |  | | | | ThermoFisher Antibodies for TMEM87B |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM87B |
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