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Aliases for TMEM87B Gene

Aliases for TMEM87B Gene

  • Transmembrane Protein 87B 2 3 5

External Ids for TMEM87B Gene

Previous GeneCards Identifiers for TMEM87B Gene

  • GC02P112530
  • GC02P112812
  • GC02P105326
  • GC02P112181
  • GC02P112184

Summaries for TMEM87B Gene

GeneCards Summary for TMEM87B Gene

TMEM87B (Transmembrane Protein 87B) is a Protein Coding gene. An important paralog of this gene is TMEM87A.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM87B Gene

Genomics for TMEM87B Gene

Regulatory Elements for TMEM87B Gene

Promoters for TMEM87B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TMEM87B on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM87B Gene

Chromosome:
2
Start:
112,055,223 bp from pter
End:
112,119,318 bp from pter
Size:
64,096 bases
Orientation:
Plus strand

Genomic View for TMEM87B Gene

Genes around TMEM87B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM87B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM87B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM87B Gene

Proteins for TMEM87B Gene

  • Protein details for TMEM87B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96K49-TM87B_HUMAN
    Recommended name:
    Transmembrane protein 87B
    Protein Accession:
    Q96K49
    Secondary Accessions:
    • A8K2M9
    • Q1RLN2
    • Q53R54

    Protein attributes for TMEM87B Gene

    Size:
    555 amino acids
    Molecular mass:
    63536 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM87B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM87B Gene

Proteomics data for TMEM87B Gene at MOPED

Post-translational modifications for TMEM87B Gene

  • Glycosylation at Asn 68, Asn 197, and Asn 272
  • Modification sites at PhosphoSitePlus

Other Protein References for TMEM87B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM87B Gene

Domains & Families for TMEM87B Gene

Protein Domains for TMEM87B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM87B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96K49

UniProtKB/Swiss-Prot:

TM87B_HUMAN :
  • Belongs to the LU7TM family. TMEM87 subfamily.
Family:
  • Belongs to the LU7TM family. TMEM87 subfamily.
genes like me logo Genes that share domains with TMEM87B: view

No data available for Gene Families for TMEM87B Gene

Function for TMEM87B Gene

Phenotypes for TMEM87B Gene

genes like me logo Genes that share phenotypes with TMEM87B: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM87B Gene

Localization for TMEM87B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM87B Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM87B Gene COMPARTMENTS Subcellular localization image for TMEM87B gene
Compartment Confidence
plasma membrane 3
golgi apparatus 2

No data available for Gene Ontology (GO) - Cellular Components for TMEM87B Gene

Pathways & Interactions for TMEM87B Gene

SuperPathways for TMEM87B Gene

No Data Available

Interacting Proteins for TMEM87B Gene

Gene Ontology (GO) - Biological Process for TMEM87B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM87B Gene

Drugs & Compounds for TMEM87B Gene

No Compound Related Data Available

Transcripts for TMEM87B Gene

Unigene Clusters for TMEM87B Gene

Transmembrane protein 87B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM87B Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19
SP1:
SP2: - - - - -

Relevant External Links for TMEM87B Gene

GeneLoc Exon Structure for
TMEM87B
ECgene alternative splicing isoforms for
TMEM87B

Expression for TMEM87B Gene

mRNA expression in normal human tissues for TMEM87B Gene

Protein differential expression in normal tissues from HIPED for TMEM87B Gene

This gene is overexpressed in Peripheral blood mononuclear cells (37.8) and Islet of Langerhans (10.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TMEM87B Gene



SOURCE GeneReport for Unigene cluster for TMEM87B Gene Hs.656298

genes like me logo Genes that share expression patterns with TMEM87B: view

Protein tissue co-expression partners for TMEM87B Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TMEM87B Gene

Orthologs for TMEM87B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TMEM87B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM87B 36
  • 100 (a)
OneToOne
TMEM87B 35
  • 99.8 (n)
  • 99.8 (a)
cow
(Bos Taurus)
Mammalia TMEM87B 35
  • 88.13 (n)
  • 86.26 (a)
TMEM87B 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM87B 36
  • 87 (a)
OneToOne
TMEM87B 35
  • 88.61 (n)
  • 86.62 (a)
mouse
(Mus musculus)
Mammalia Tmem87b 16
Tmem87b 36
  • 88 (a)
OneToOne
Tmem87b 35
  • 87.24 (n)
  • 88.45 (a)
oppossum
(Monodelphis domestica)
Mammalia TMEM87B 36
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM87B 36
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem87b 35
  • 87.06 (n)
  • 88.99 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 45 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.3577 35
tmem87b 35
  • 67.58 (n)
  • 63.67 (a)
zebrafish
(Danio rerio)
Actinopterygii TMEM87B (1 of 2) 36
  • 47 (a)
OneToMany
TMEM87B (2 of 2) 36
  • 68 (a)
OneToMany
tmem87b 35
  • 68.43 (n)
  • 70.29 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007934 35
  • 54.7 (n)
  • 51.36 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG17660 35
  • 50.23 (n)
  • 43.64 (a)
CG17660 36
  • 39 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C52B9.4 35
  • 52.76 (n)
  • 47.51 (a)
C52B9.4 36
  • 32 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
  • 16 (a)
ManyToMany
PTM1 36
  • 17 (a)
ManyToMany
PTM1 38
Species with no ortholog for TMEM87B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMEM87B Gene

ENSEMBL:
Gene Tree for TMEM87B (if available)
TreeFam:
Gene Tree for TMEM87B (if available)

Paralogs for TMEM87B Gene

Paralogs for TMEM87B Gene

(1) SIMAP similar genes for TMEM87B Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TMEM87B: view

Variants for TMEM87B Gene

Sequence variations from dbSNP and Humsavar for TMEM87B Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1045295 -- 112,116,691(+) TCCGC(C/T)CCCCC utr-variant-3-prime
rs1045300 -- 112,117,462(+) AGCCT(A/G/T)CCTTC utr-variant-3-prime
rs2067928 -- 112,093,004(-) AAGAC(A/G)TAAGT intron-variant
rs3185182 -- 112,116,592(+) ACTAG(A/C/G)TGCAA utr-variant-3-prime
rs3842568 -- 112,113,126(+) ATAAA(-/TACT)TACTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM87B Gene

Variant ID Type Subtype PubMed ID
nsv521956 CNV Loss 19592680
nsv874863 CNV Loss 21882294
dgv4278n71 CNV Gain 21882294
nsv829620 CNV Gain 20364138
esv2720519 CNV Deletion 23290073
esv29608 CNV Loss 19812545
nsv821426 CNV Deletion 20802225
esv2720520 CNV Deletion 23290073
esv2720521 CNV Deletion 23290073
esv2720522 CNV Deletion 23290073
esv1378320 CNV Deletion 17803354
esv1510816 CNV Deletion 17803354
esv2057185 CNV Deletion 18987734
dgv654e201 CNV Deletion 23290073
esv2720524 CNV Deletion 23290073
esv2720526 CNV Deletion 23290073

Variation tolerance for TMEM87B Gene

Residual Variation Intolerance Score: 16.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.90; 89.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM87B Gene

HapMap Linkage Disequilibrium report
TMEM87B
Human Gene Mutation Database (HGMD)
TMEM87B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM87B Gene

Disorders for TMEM87B Gene

Relevant External Links for TMEM87B

Genetic Association Database (GAD)
TMEM87B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM87B

No disorders were found for TMEM87B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM87B Gene

Publications for TMEM87B Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Screening for novel binding proteins interacting with human papillomavirus type 18 E6 oncogene in the Hela cDNA library by yeast two-hybrid system. (PMID: 18278468) Li S. … Ma D. (J. Huazhong Univ. Sci. Technol. Med. Sci. 2008) 23
  4. Expression of TMEM87B interacting with the human papillomavirus type 18 E6 oncogene in the Hela cDNA library by a yeast two-hybrid system. (PMID: 18636207) Li S. … Ma D. (Oncol. Rep. 2008) 23
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for TMEM87B Gene

Sources for TMEM87B Gene

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