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Aliases for TMEM87A Gene

Aliases for TMEM87A Gene

  • Transmembrane Protein 87A 2 3 5

External Ids for TMEM87A Gene

Previous GeneCards Identifiers for TMEM87A Gene

  • GC15M040291
  • GC15M042502
  • GC15M019350

Summaries for TMEM87A Gene

GeneCards Summary for TMEM87A Gene

TMEM87A (Transmembrane Protein 87A) is a Protein Coding gene. An important paralog of this gene is TMEM87B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM87A Gene

Genomics for TMEM87A Gene

Regulatory Elements for TMEM87A Gene

Promoters for TMEM87A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TMEM87A on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM87A Gene

Chromosome:
15
Start:
42,210,452 bp from pter
End:
42,274,526 bp from pter
Size:
64,075 bases
Orientation:
Minus strand

Genomic View for TMEM87A Gene

Genes around TMEM87A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM87A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM87A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM87A Gene

Proteins for TMEM87A Gene

  • Protein details for TMEM87A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NBN3-TM87A_HUMAN
    Recommended name:
    Transmembrane protein 87A
    Protein Accession:
    Q8NBN3
    Secondary Accessions:
    • Q6NT77
    • Q8NCA4
    • Q9BS46
    • Q9P103
    • Q9Y3Y7

    Protein attributes for TMEM87A Gene

    Size:
    555 amino acids
    Molecular mass:
    63430 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC11598.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TMEM87A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM87A Gene

Proteomics data for TMEM87A Gene at MOPED

Post-translational modifications for TMEM87A Gene

  • Ubiquitination at Lys 397
  • Glycosylation at Asn 79, Asn 127, Asn 157, and Asn 160
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TMEM87A Gene

Domains & Families for TMEM87A Gene

Protein Domains for TMEM87A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM87A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NBN3

UniProtKB/Swiss-Prot:

TM87A_HUMAN :
  • Belongs to the LU7TM family. TMEM87 subfamily.
Family:
  • Belongs to the LU7TM family. TMEM87 subfamily.
genes like me logo Genes that share domains with TMEM87A: view

No data available for Gene Families for TMEM87A Gene

Function for TMEM87A Gene

Phenotypes for TMEM87A Gene

genes like me logo Genes that share phenotypes with TMEM87A: view

Animal Model Products

CRISPR Products

miRNA for TMEM87A Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM87A Gene

Localization for TMEM87A Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM87A Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM87A Gene COMPARTMENTS Subcellular localization image for TMEM87A gene
Compartment Confidence
golgi apparatus 4
plasma membrane 3
nucleus 2
endoplasmic reticulum 1
endosome 1

No data available for Gene Ontology (GO) - Cellular Components for TMEM87A Gene

Pathways & Interactions for TMEM87A Gene

SuperPathways for TMEM87A Gene

No Data Available

Interacting Proteins for TMEM87A Gene

Gene Ontology (GO) - Biological Process for TMEM87A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM87A Gene

Drugs & Compounds for TMEM87A Gene

No Compound Related Data Available

Transcripts for TMEM87A Gene

Unigene Clusters for TMEM87A Gene

Transmembrane protein 87A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM87A Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20
SP1: -
SP2: - -
SP3:

Relevant External Links for TMEM87A Gene

GeneLoc Exon Structure for
TMEM87A
ECgene alternative splicing isoforms for
TMEM87A

Expression for TMEM87A Gene

mRNA expression in normal human tissues for TMEM87A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TMEM87A Gene

This gene is overexpressed in Islet of Langerhans (13.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TMEM87A Gene



SOURCE GeneReport for Unigene cluster for TMEM87A Gene Hs.744941

genes like me logo Genes that share expression patterns with TMEM87A: view

Protein tissue co-expression partners for TMEM87A Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TMEM87A Gene

Orthologs for TMEM87A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TMEM87A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TMEM87A 35
  • 92.61 (n)
  • 94.77 (a)
TMEM87A 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM87A 35
  • 93.45 (n)
  • 95.5 (a)
mouse
(Mus musculus)
Mammalia Tmem87a 35
  • 89.23 (n)
  • 92.78 (a)
Tmem87a 16
Tmem87a 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TMEM87A 35
  • 99.82 (n)
  • 99.82 (a)
TMEM87A 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem87a 35
  • 87.75 (n)
  • 90.45 (a)
oppossum
(Monodelphis domestica)
Mammalia TMEM87A 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM87A 36
  • 41 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM87A 35
  • 75.84 (n)
  • 80.11 (a)
TMEM87A 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM87A 36
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem87a 35
  • 68.53 (n)
  • 71.81 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
zgc:162698 35
  • 59.7 (n)
  • 54.1 (a)
TMEM87A 36
  • 47 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG17660 36
  • 39 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C52B9.4 36
  • 31 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
  • 14 (a)
ManyToMany
PTM1 36
  • 17 (a)
ManyToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3403 35
Species with no ortholog for TMEM87A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMEM87A Gene

ENSEMBL:
Gene Tree for TMEM87A (if available)
TreeFam:
Gene Tree for TMEM87A (if available)

Paralogs for TMEM87A Gene

Paralogs for TMEM87A Gene

(1) SIMAP similar genes for TMEM87A Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with TMEM87A: view

Variants for TMEM87A Gene

Sequence variations from dbSNP and Humsavar for TMEM87A Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1679011 -- 42,237,204(-) TAGTG(A/G)CCATT intron-variant
rs1679012 -- 42,236,478(-) TATTG(A/G)CATCT intron-variant
rs1630294 -- 42,231,867(-) CAGCA(A/G)TTGAC intron-variant, reference, missense, utr-variant-3-prime
rs1712408 -- 42,237,114(-) GCTGT(A/C)AATTT intron-variant
rs1712409 -- 42,237,009(-) ATCAA(C/G)AAAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM87A Gene

Variant ID Type Subtype PubMed ID
nsv471683 CNV Gain+Loss 15918152
nsv832985 CNV Loss 17160897
nsv827308 CNV Gain 20364138
nsv904133 CNV Gain 21882294
esv1006302 CNV Deletion 20482838
nsv827310 CNV Loss 20364138

Variation tolerance for TMEM87A Gene

Residual Variation Intolerance Score: 6.81% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.06; 21.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM87A Gene

HapMap Linkage Disequilibrium report
TMEM87A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM87A Gene

Disorders for TMEM87A Gene

Relevant External Links for TMEM87A

Genetic Association Database (GAD)
TMEM87A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM87A

No disorders were found for TMEM87A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM87A Gene

Publications for TMEM87A Gene

  1. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. HAUSP regulates c-MYC expression via de-ubiquitination of TRRAP. (PMID: 25925205) Bhattacharya S. … Ghosh M.K. (Cell Oncol (Dordr) 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for TMEM87A Gene

Sources for TMEM87A Gene

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