TMEM87A Gene
protein-coding GIFtS: 46
GCID: GC15M042502
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transmembrane protein 87A
| |
Aliases
for TMEM87A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Transmembrane Protein 87A1 2 | | DKFZP564G20221 |
Export aliases for TMEM87A gene to outside databasesPrevious GC identifers: GC15M040291 GC15M019350 |
Summaries
for TMEM87A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for TMEM87A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000015.9 NC_018926.1 NT_010194.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TMEM87A gene promoter:
LHX3b/Lhx3b Pax-6 POU3F2 (N-Oct-5b) POU3F2 (N-Oct-5a) POU3F2 GATA-1 POU2F1 POU2F1a LHX3a/Lhx3a aMEF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for TMEM87A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM87A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 15q15.1 Ensembl cytogenetic band: 15q15.1 HGNC cytogenetic band: 15q15.1TMEM87A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 15 GeneLoc Exon Structure GeneLoc location for GC15M042502: view genomic region
(about GC identifiers)
Start:
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42,502,726 bp from pter |
End:
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42,565,861 bp from pter |
Size:
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63,136 bases |
Orientation:
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minus strand |
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Proteins
for TMEM87A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TM87A_HUMAN, Q8NBN3 (See
protein sequence)Recommended Name: Transmembrane protein 87A precursor Size: 555 amino acids; 63430 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Sequence caution: Sequence=BAC11598.1; Type=Erroneous initiation;
Secondary accessions: Q6NT77 Q8NCA4 Q9BS46 Q9P103 Q9Y3Y7Alternative splicing: 3 isoforms: Q8NBN3-1 Q8NBN3-2 Q8NBN3-3 Explore the universe of human proteins at neXtProt for TMEM87A: NX_Q8NBN3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8NBN3
TMEM87A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001103973.1 NP_056312.2
ENSEMBL proteins: ENSP00000374484 ENSP00000457308 ENSP00000456225 ENSP00000454539 ENSP00000455343 ENSP00000457874 ENSP00000454278 ENSP00000305894 ENSP00000456940 ENSP00000405379
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
TMEM87A for ontologies About GeneDecksing
TMEM87A Antibody Products:
Assay Products for TMEM87A: |
Protein
Domains /
Families
for TMEM87A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TMEM87A for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8NBN3ProtoNet protein and cluster: Q8NBN3 UniProtKB/Swiss-Prot: TM87A_HUMAN, Q8NBN3Similarity: Belongs to the LU7TM family. TMEM87 subfamily |
Function
for TMEM87A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM87A (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM87A (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for TMEM87A | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM87A |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM87A |
|
Pathways & Interactions
for TMEM87A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMEM87A
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
2 Interacting proteins for TMEM87A (Q8NBN33 ENSP000003744844) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for TMEM87A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TMEM87A
Search CenterWatch for drugs/clinical trials and news about TMEM87A / TM87A
|
Transcripts
for TMEM87A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TMEM87A gene (2 alternative transcripts): NM_001110503.1 NM_015497.3 Unigene Cluster for TMEM87A: Transmembrane protein 87A Hs.511138 [show with all ESTs]Unigene Representative Sequence: NM_01549713 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000389834(uc021sjr.1 uc001zpf.4) ENST00000568067 ENST00000564329
ENST00000566014 ENST00000562946 ENST00000569075(uc010bcu.1) ENST00000568400
ENST00000563371 ENST00000561578 ENST00000566474 ENST00000307216(uc001zpg.2)
ENST00000568432 ENST00000448392
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM87A (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM87A (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): TMEM87A (NM_001110503) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMEM87A | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM87A |
Additional cDNA sequence: AF129927.1 AF132733.1 AK023569.1 AK074870.1 AK075403.1 AK289591.1 AK290150.1 AK290484.1 AK297816.1 AK309915.1 AK309954.1 AL049944.1 BC005335.1 BC069240.1 24/28 DOTS entries (see all 28): DT.100756508 DT.91754353 DT.119202 DT.40125682 DT.121036594 DT.100885888 DT.100666308 DT.100885872 DT.121036797 DT.100885890 DT.92068224 DT.121036738 DT.99994874 DT.91655888 DT.92039021 DT.95231928 DT.101970020 DT.121036568 DT.121036573 DT.121036675 DT.121036709 DT.91754346 DT.91754347 DT.91754355 24/414 AceView cDNA sequences (see all 414): BM311040 AA716674 AA176694 BQ225871 AW337120 BI495512 AA865105 AI148799 BM927105 AA262823 AI619512 AI498904 BM839192 T59024 BU620168 AW418736 BE296569 AA027834 AI672113 AA873790 AA635630 N31860 AA854320 BM980131
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for TMEM87A About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 |
|---|
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| SP1: | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | - | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for TMEM87A
|
Expression
for TMEM87A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TMEM87A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCACTTTTTA
About this image
See TMEM87A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TMEM87A
SOURCE GeneReport for Unigene cluster: Hs.511138
SABiosciences Custom PCR Arrays for TMEM87A
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM87A
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TMEM87A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM87A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM87A | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM87A |
Orthologs
for TMEM87A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for TMEM87A gene from 9/27 species (see all 27) About this table
ENSEMBL Gene Tree for TMEM87A (if available)
TreeFam Gene Tree for TMEM87A (if available) |
Paralogs
for TMEM87A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TMEM87A gene
- TMEM87B2
1 SIMAP similar gene for TMEM87A using alignment to 8 protein entries: TM87A_HUMAN (see all proteins):TMEM87B
TMEM87A for paralogs About GeneDecksing
|
Genomic Variants
for TMEM87A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 15 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TMEM87A (42502726 - 42565861 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for TMEM87A
1 CNV: 0785 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMEM87A |
|
Disorders
/ Diseases
for TMEM87A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TMEM87A for disorders About GeneDecksing
6  diseases for TMEM87A: About MalaCardscongenital dyserythropoietic anemia type i congenital dyserythropoietic anemia dyserythropoietic anemia angelman syndrome
anemia malaria
Export disorders for TMEM87A gene to outside databases
|
Publications
for TMEM87A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TMEM87A gene, integrated from 9 sources (see all 19):
(articles sorted by number of sources associating them with TMEM87A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- A data set of human endogenous protein ubiquitination sites. (PubMed id 20972266)1 Shi Y....Qin J. (2011)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
|
External Searches for TMEM87A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TMEM87A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TMEM87A gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TMEM87A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TMEM87A | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TMEM87A gene:
Search GeneIP for patents involving TMEM87A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TMEM87A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TMEM87A | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMEM87A | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM87A | | | OriGene Protein Over-expression Lysate for TMEM87A | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TMEM87A | | OriGene 3'-UTR Clone for TMEM87A | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM87A | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM87A | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TMEM87A | | OriGene Custom Protein Services for TMEM87A | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TMEM87A | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMEM87A | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM87A | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMEM87A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM87A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM87A |
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| | | | Search Tocris compounds for TMEM87A |
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 |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM87A |
|  |  |  | | | | Search ThermoFisher Antibodies for TMEM87A |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM87A |
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