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Aliases for TMEM87A Gene

Aliases for TMEM87A Gene

  • Transmembrane Protein 87A 2 3 5

External Ids for TMEM87A Gene

Previous GeneCards Identifiers for TMEM87A Gene

  • GC15M040291
  • GC15M042502
  • GC15M019350

Summaries for TMEM87A Gene

GeneCards Summary for TMEM87A Gene

TMEM87A (Transmembrane Protein 87A) is a Protein Coding gene. An important paralog of this gene is TMEM87B.

Additional gene information for TMEM87A Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM87A Gene

Genomics for TMEM87A Gene

Regulatory Elements for TMEM87A Gene

Enhancers for TMEM87A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15H042490 1.4 ENCODE dbSUPER 19.3 -216.7 -216743 2 PKNOX1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF766 CBX5 LRRC57 TMEM87A GANC HAUS2 RPS3AP47 SNAP23 ENSG00000261684
GH15H043122 1 ENCODE 18.3 -848.5 -848540 1 PKNOX1 ATF1 BRCA1 YY1 GLIS2 ELK1 ATF7 SP3 MCM3 GTF2B LRRC57 RPS3AP47 GANC WDR76 LOC105370795 TMEM87A CDAN1 VPS39 SNAP23 MFAP1
GH15H042493 1.7 FANTOM5 ENCODE dbSUPER 9.6 -220.8 -220779 3 HDGF PKNOX1 ARNT ARID4B SIN3A YBX1 DMAP1 ZNF2 YY1 SLC30A9 LRRC57 HAUS2 GANC TMEM87A ZSCAN29 SNAP23 ADAL TTBK2 ENSG00000261684
GH15H041620 1.1 ENCODE 12.6 +652.9 652944 2 MLX ARID4B DMAP1 YY1 ZNF143 DEK SP3 SP5 ZHX2 MXD4 RAD51-AS1 ENSG00000260814 MGA TMEM87A VPS39 GANC INO80 PLA2G4B GC15P041622
GH15H042497 1.5 Ensembl ENCODE dbSUPER 9 -225.1 -225082 4 HDGF PKNOX1 ARNT FEZF1 TCF12 GTF3C2 ATF7 FOS MEF2D SMARCA4 LRRC57 TUBGCP4 GANC MGA LCMT2 CDAN1 HAUS2 ENSG00000260814 LOC105370795 RPAP1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM87A on UCSC Golden Path with GeneCards custom track

Promoters for TMEM87A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000075738 -874 801 HDGF SMARCE1 ZNF639 CAVIN1 NR4A1 E2F5 TEAD2 RELA GTF3C2 SMARCA4
ENSR00000277264 1226 3001 PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF143

Genomic Location for TMEM87A Gene

Chromosome:
15
Start:
42,210,452 bp from pter
End:
42,274,526 bp from pter
Size:
64,075 bases
Orientation:
Minus strand

Genomic View for TMEM87A Gene

Genes around TMEM87A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM87A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM87A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM87A Gene

Proteins for TMEM87A Gene

  • Protein details for TMEM87A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NBN3-TM87A_HUMAN
    Recommended name:
    Transmembrane protein 87A
    Protein Accession:
    Q8NBN3
    Secondary Accessions:
    • Q6NT77
    • Q8NCA4
    • Q9BS46
    • Q9P103
    • Q9Y3Y7

    Protein attributes for TMEM87A Gene

    Size:
    555 amino acids
    Molecular mass:
    63430 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC11598.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TMEM87A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM87A Gene

Post-translational modifications for TMEM87A Gene

  • Ubiquitination at posLast=397397
  • Glycosylation at posLast=7979, Asn127, posLast=157157, and Asn160
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TMEM87A Gene

Domains & Families for TMEM87A Gene

Gene Families for TMEM87A Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for TMEM87A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM87A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NBN3

UniProtKB/Swiss-Prot:

TM87A_HUMAN :
  • Belongs to the LU7TM family. TMEM87 subfamily.
Family:
  • Belongs to the LU7TM family. TMEM87 subfamily.
genes like me logo Genes that share domains with TMEM87A: view

Function for TMEM87A Gene

Phenotypes From GWAS Catalog for TMEM87A Gene

Phenotypes for TMEM87A Gene

genes like me logo Genes that share phenotypes with TMEM87A: view

Animal Model Products

CRISPR Products

miRNA for TMEM87A Gene

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TMEM87A
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM87A Gene

Localization for TMEM87A Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM87A Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM87A gene
Compartment Confidence
golgi apparatus 4
plasma membrane 3
nucleus 2
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TMEM87A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IEA --
GO:0016021 integral component of membrane IEA --
GO:0032580 Golgi cisterna membrane IDA 26157166
genes like me logo Genes that share ontologies with TMEM87A: view

Pathways & Interactions for TMEM87A Gene

SuperPathways for TMEM87A Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMEM87A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042147 retrograde transport, endosome to Golgi IGI 26157166
genes like me logo Genes that share ontologies with TMEM87A: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM87A Gene

Drugs & Compounds for TMEM87A Gene

No Compound Related Data Available

Transcripts for TMEM87A Gene

Unigene Clusters for TMEM87A Gene

Transmembrane protein 87A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TMEM87A
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM87A Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20
SP1: -
SP2: - -
SP3:

Relevant External Links for TMEM87A Gene

GeneLoc Exon Structure for
TMEM87A
ECgene alternative splicing isoforms for
TMEM87A

Expression for TMEM87A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM87A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TMEM87A Gene

This gene is overexpressed in Islet of Langerhans (13.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TMEM87A Gene



Protein tissue co-expression partners for TMEM87A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TMEM87A Gene:

TMEM87A

SOURCE GeneReport for Unigene cluster for TMEM87A Gene:

Hs.744941

Evidence on tissue expression from TISSUES for TMEM87A Gene

  • Nervous system(4.9)
  • Liver(4.2)
  • Lung(3.3)
  • Kidney(2.9)
  • Adrenal gland(2.7)
  • Intestine(2.7)
  • Pancreas(2.7)
  • Stomach(2.7)
genes like me logo Genes that share expression patterns with TMEM87A: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM87A Gene

Orthologs for TMEM87A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TMEM87A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM87A 33 34
  • 99.82 (n)
dog
(Canis familiaris)
Mammalia TMEM87A 33
  • 93.45 (n)
cow
(Bos Taurus)
Mammalia TMEM87A 33 34
  • 92.61 (n)
mouse
(Mus musculus)
Mammalia Tmem87a 33 16 34
  • 89.23 (n)
rat
(Rattus norvegicus)
Mammalia Tmem87a 33
  • 87.75 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM87A 34
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM87A 34
  • 41 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM87A 33 34
  • 75.84 (n)
lizard
(Anolis carolinensis)
Reptilia TMEM87A 34
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem87a 33
  • 68.53 (n)
zebrafish
(Danio rerio)
Actinopterygii zgc:162698 33
  • 59.7 (n)
TMEM87A 34
  • 47 (a)
OneToOne
-- 33
fruit fly
(Drosophila melanogaster)
Insecta CG17660 34
  • 39 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C52B9.4 34
  • 31 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PTM1 34
  • 17 (a)
ManyToMany
-- 34
  • 14 (a)
ManyToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3403 33
Species where no ortholog for TMEM87A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMEM87A Gene

ENSEMBL:
Gene Tree for TMEM87A (if available)
TreeFam:
Gene Tree for TMEM87A (if available)

Paralogs for TMEM87A Gene

Paralogs for TMEM87A Gene

(1) SIMAP similar genes for TMEM87A Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with TMEM87A: view

Variants for TMEM87A Gene

Sequence variations from dbSNP and Humsavar for TMEM87A Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1000019196 -- 42,253,475(+) CCACT(C/T)CAGCC intron-variant
rs1000044449 -- 42,243,804(+) CATGA(A/G)CCACC intron-variant
rs1000111738 -- 42,250,058(+) TTAAA(A/G)TCTGT intron-variant
rs1000121375 -- 42,237,956(+) GACTA(C/T)ATATG intron-variant
rs1000124764 -- 42,249,845(+) GTCTC(A/G)TTGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM87A Gene

Variant ID Type Subtype PubMed ID
esv1006302 CNV deletion 20482838
nsv1054102 CNV gain 25217958
nsv471683 CNV gain+loss 15918152
nsv827308 CNV gain 20364138
nsv827310 CNV loss 20364138
nsv832985 CNV loss 17160897

Variation tolerance for TMEM87A Gene

Residual Variation Intolerance Score: 6.81% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.06; 21.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM87A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM87A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM87A Gene

Disorders for TMEM87A Gene

Relevant External Links for TMEM87A

Genetic Association Database (GAD)
TMEM87A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM87A

No disorders were found for TMEM87A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM87A Gene

Publications for TMEM87A Gene

  1. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3 4 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60

Products for TMEM87A Gene

Sources for TMEM87A Gene

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