TMEM86B Gene
protein-coding GIFtS : 43
GCID: GC19 M055738
transmembrane protein 86B
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Aliasesfor TMEM86B gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Transmembrane Protein 86B 1 2 3 MGC302081 Lysoplasmalogenase1 EC 3.3.2.23 EC 3.3.2.53
Export aliases for TMEM86B gene to outside databases Previous GC identifers: GC19M060430 GC19M052061
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Summariesfor TMEM86B gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: TM86B_HUMAN, Q8N661 Function : Enzyme catalyzing the degradation of lysoplasmalogen. Lysoplasmalogens are formed by the hydrolysis of theabundant membrane glycerophospholipids plasmalogens. May control the respective levels of plasmalogens and lysoplasmalogens in cells and modulate cell membrane properties
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Genomic Viewsfor TMEM86B gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000019.9 NC_018930.1 NT_011109.16 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the TMEM86B gene promoter: NRSF form 1 MyoD POU6F1 (c2) HNF-4alpha2 NRSF form 2 FOXL1 c-Ets-1 HNF-4alpha1 STAT3 MRF-2 Other transcription factors Search SABiosciences Chromatin IP Primers for TMEM86B Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM86B
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 19q13.42 Ensembl cytogenetic band: 19q13.42 HGNC cytogenetic band: 19q13.42 TMEM86B Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 19 GeneLoc Exon Structure
GeneLoc location for GC19M055738: view genomic region
(about GC identifiers )
Start:
55,738,002 bp from pter
End:
55,741,647 bp from pter
Size:
3,646 bases
Orientation:
minus strand
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Proteinsfor TMEM86B gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: TM86B_HUMAN, Q8N661 (See
protein sequence )Recommended Name: Lysoplasmalogenase Size : 226 amino acids; 24352 Da
Subunit : Homodimer (Probable)
Subcellular location : Membrane; Multi-pass membrane protein (Potential). CytoplasmExplore the universe of human proteins at neXtProt for TMEM86B: NX_Q8N661 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q8N661 TMEM86B Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins: NP_776165.3 ENSEMBL proteins: ENSP00000321038 Human Recombinant Protein Products for TMEM86B: Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view) : About this table
TMEM86B for ontologies About GeneDecksing TMEM86B Antibody Products: Assay Products for TMEM86B:
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Protein
Domains / Familiesfor TMEM86B gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
TMEM86B for domains About GeneDecksing 1 InterPro domain/family :
Graphical View of Domain Structure for InterPro Entry Q8N661 ProtoNet protein and cluster: Q8N661
1 Blocks protein family : IPB012506 YhhN-like UniProtKB/Swiss-Prot: TM86B_HUMAN, Q8N661 Similarity : Belongs to the TMEM86 family
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Functionfor TMEM86B gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory ,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase ,
shRNA from
OriGene ,
Sirion Biotech ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Sirion Biotech ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
Sirion Biotech ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Molecular Function: UniProtKB/Swiss-Prot Summary: TM86B_HUMAN, Q8N661 Function : Enzyme catalyzing the degradation of lysoplasmalogen. Lysoplasmalogens are formed by the hydrolysis of theabundant membrane glycerophospholipids plasmalogens. May control the respective levels of plasmalogens and lysoplasmalogens in cells and modulate cell membrane properties Catalytic activity : 1-(1-alkenyl)-sn-glycero-3-phosphocholine + H(2)O = an aldehyde + sn-glycero-3-phosphocholineCatalytic activity : 1-(1-alkenyl)-sn-glycero-3-phosphoethanolamine + H(2)O = an aldehyde +sn-glycero-3-phosphoethanolamine Enzyme regulation : Competitively inhibited by lysophosphatidic acidBiophysicochemical properties : Kinetic parameters: KM=45 uM for lysoplasmenyl-choline; KM=53 uM forlysoplasmenyl-ethanolamine; pH dependence: Optimum pH is 6.95 and 7.05 with lysoplasmenyl-ethanolamine and lysoplasmenyl-choline as substrates, respectively; Enzyme Numbers (IUBMB): EC 3.3.2.2 1 EC 3.3.2.5 1
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0047408 alkenylglycerophosphocholine hydrolase activity
IDA -- GO:0047409 alkenylglycerophosphoethanolamine hydrolase activity
IDA --
TMEM86B for ontologies About GeneDecksing Phenotypes: 1 GenomeRNAi human phenotype for TMEM86B :Animal Models: Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for TMEM86B (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for TMEM86BOriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: TMEM86B (NM_173804 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMEM86B Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat TMEM86B
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM86B
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Pathways & Interactionsfor TMEM86B gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMEM86B STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)1 Interacting protein for TMEM86B (ENSP00000321038 4 ) via UniProtKB, MINT, STRING , and/or I2D About this table Gene Ontology (GO): 1 biological process term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0046485 ether lipid metabolic process
IDA --
TMEM86B for ontologies About GeneDecksing
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Drugs & Compoundsfor TMEM86B gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for TMEM86B Search CenterWatch for drugs/clinical trials and news about TMEM86B / TM86B
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Transcriptsfor TMEM86B gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
Sirion Biotech ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for TMEM86B gene: NM_173804.4 Unigene Cluster for TMEM86B:
Transmembrane protein 86B Hs.135215 [show with all ESTs ] Unigene Representative Sequence: AK127755 4 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000589190 ENST00000327042 (uc002qjt.3 uc002qju.3 ) ENST00000585416 ENST00000586923 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for TMEM86B (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for TMEM86BOriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: TMEM86B (NM_173804 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMEM86B Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat TMEM86B
Additional cDNA sequence: AK127755.1 BC023000.1
3 DOTS entries : DT.100019965 DT.423689
DT.446411 24/362 AceView cDNA sequences (see all 362 ):
BM824717 BQ677114 BQ682703 BM810799 CR595325 BE513401 BQ888296 CB155253 AL703312 BQ063473 AL040848 CO246210 BQ064215 BQ920736 BM786186 CB852961 BQ054504 CF125931 CN479984 BM725215 BM449832 AA689488 BI868429 BQ226010 GeneLoc Exon Structure
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Expression for TMEM86B gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section TMEM86B expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: TTCACTGTCGAbout this image TMEM86B expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table
Stem Cell Differentiation: 1 LifeMap Cell Name Category Late limb mesenchymal cells (LLM cells) (Primary Cell)Bone, Cartilage, Limb Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See TMEM86B Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for TMEM86B SOURCE GeneReport for Unigene cluster: Hs.135215 SABiosciences Custom PCR Arrays for TMEM86B Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for TMEM86BBrowse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat TMEM86B QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat TMEM86B QIAGEN QuantiFast Probe-based Assays in human , mouse , rat TMEM86B In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM86B
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Orthologsfor TMEM86B gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of animals.
Orthologs for TMEM86B gene from 4/17 species (see all 17 ) About this table
ENSEMBL Gene Tree for TMEM86B (if available)TreeFam Gene Tree for TMEM86B (if available)
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Paralogsfor TMEM86B gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for TMEM86B gene TMEM86A 2 1 SIMAP similar gene for TMEM86B using alignment to 1 protein entry: TM86B_HUMAN :TMEM86A
TMEM86B for paralogs About GeneDecksing
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Genomic Variantsfor TMEM86B gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 19 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for TMEM86B (55738002 - 55741647 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for TMEM86B: --
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing TMEM86B
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Disorders
/ Diseasesfor TMEM86B gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section --
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Publicationsfor TMEM86B gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for TMEM86B gene integrated from 9 sources : (articles sorted by number of sources associating them with TMEM86B) Utopia : connect your pdf to the dynamic world of online information
Purification, identification, and cloning of lysoplasmalogenase, the enzyme that catalyzes hydrolysis of the vinyl ether bond of lysoplasmalogen. (PubMed id 21515882) 1 , 2 , 3 Wu L.C....Jurkowitz M.S. (2011) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606) 1 Lin Y.Y....Boeke J.D. (2012) hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965) 1 Lamesch P.... Vidal M. (2007) The DNA sequence and biology of human chromosome 19. (PubMed id 15057824) 2 Grimwood J.... Lucas S.M. (2004) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002)
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External Searches for TMEM86B gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing TMEM86B gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing TMEM86B gene
(According to HUGE )
About This Section --
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Specialized Databases showing TMEM86B gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for TMEM86B Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for TMEM86B gene: Search GeneIP for patents involving TMEM86B GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor TMEM86B gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 and Sirion Biotech , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript , LifeMap BioReagents , and Sirion Biotech , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences , In Situ Hybridization Assays from Advanced Cell Diagnostics , Animal models from inGenious Targeting Laboratory )About This Section
Browse OriGene Antibodies OriGene shRNA RFP for TMEM86B OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for TMEM86B OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for TMEM86B OriGene Protein Over-expression Lysate for TMEM86B Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for TMEM86B OriGene 3'-UTR Clone for TMEM86B OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for TMEM86B OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for TMEM86B Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for TMEM86B OriGene Custom Protein Services for TMEM86B OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TMEM86B QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing TMEM86B QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM86B QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat TMEM86B QIAGEN QuantiFast Probe-based Assays in human , mouse , rat TMEM86B QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat TMEM86B
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TMEM86B Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM86B
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Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat TMEM86B
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