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Aliases for TMEM86B Gene

Aliases for TMEM86B Gene

  • Transmembrane Protein 86B 2 3 4
  • Lysoplasmalogenase 3
  • EC 3.3.2.2 4
  • EC 3.3.2.5 4

External Ids for TMEM86B Gene

Previous GeneCards Identifiers for TMEM86B Gene

  • GC19M060430
  • GC19M055738
  • GC19M052061

Summaries for TMEM86B Gene

GeneCards Summary for TMEM86B Gene

TMEM86B is a Protein Coding gene. GO annotations related to this gene include alkenylglycerophosphocholine hydrolase activity and alkenylglycerophosphoethanolamine hydrolase activity. An important paralog of this gene is TMEM86A.

UniProtKB/Swiss-Prot for TMEM86B Gene

  • Enzyme catalyzing the degradation of lysoplasmalogen. Lysoplasmalogens are formed by the hydrolysis of the abundant membrane glycerophospholipids plasmalogens. May control the respective levels of plasmalogens and lysoplasmalogens in cells and modulate cell membrane properties.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM86B Gene

Genomics for TMEM86B Gene

Regulatory Elements for TMEM86B Gene

Genomic Location for TMEM86B Gene

Start:
55,226,634 bp from pter
End:
55,229,264 bp from pter
Size:
2,631 bases
Orientation:
Minus strand

Genomic View for TMEM86B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM86B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM86B Gene

Proteins for TMEM86B Gene

  • Protein details for TMEM86B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N661-TM86B_HUMAN
    Recommended name:
    Lysoplasmalogenase
    Protein Accession:
    Q8N661
    Secondary Accessions:

    Protein attributes for TMEM86B Gene

    Size:
    226 amino acids
    Molecular mass:
    24352 Da
    Quaternary structure:
    • Homodimer.

neXtProt entry for TMEM86B Gene

Proteomics data for TMEM86B Gene at MOPED

Post-translational modifications for TMEM86B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM86B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM86B Gene

Domains for TMEM86B Gene

Protein Domains for TMEM86B Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM86B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N661

UniProtKB/Swiss-Prot:

TM86B_HUMAN :
  • Q8N661
Family:
  • Belongs to the TMEM86 family.
genes like me logo Genes that share domains with TMEM86B: view

No data available for Gene Families for TMEM86B Gene

Function for TMEM86B Gene

Molecular function for TMEM86B Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=45 uM for lysoplasmenyl-choline {ECO:0000269 PubMed:21515882}; KM=53 uM for lysoplasmenyl-ethanolamine {ECO:0000269 PubMed:21515882}; pH dependence: Optimum pH is 6.95 and 7.05 with lysoplasmenyl-ethanolamine and lysoplasmenyl-choline as substrates, respectively. {ECO:0000269 PubMed:21515882};
UniProtKB/Swiss-Prot CatalyticActivity: 1-(1-alkenyl)-sn-glycero-3-phosphocholine + H(2)O = an aldehyde + sn-glycero-3-phosphocholine.
UniProtKB/Swiss-Prot CatalyticActivity: 1-(1-alkenyl)-sn-glycero-3-phosphoethanolamine + H(2)O = an aldehyde + sn-glycero-3-phosphoethanolamine.
UniProtKB/Swiss-Prot EnzymeRegulation: Competitively inhibited by lysophosphatidic acid.
UniProtKB/Swiss-Prot Function: Enzyme catalyzing the degradation of lysoplasmalogen. Lysoplasmalogens are formed by the hydrolysis of the abundant membrane glycerophospholipids plasmalogens. May control the respective levels of plasmalogens and lysoplasmalogens in cells and modulate cell membrane properties.

Enzyme Numbers (IUBMB) for TMEM86B Gene

Gene Ontology (GO) - Molecular Function for TMEM86B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0047408 alkenylglycerophosphocholine hydrolase activity IDA 21515882
GO:0047409 alkenylglycerophosphoethanolamine hydrolase activity IDA 21515882
genes like me logo Genes that share ontologies with TMEM86B: view

Phenotypes for TMEM86B Gene

GenomeRNAi human phenotypes for TMEM86B:
genes like me logo Genes that share phenotypes with TMEM86B: view

Animal Model Products

CRISPR Products

miRNA for TMEM86B Gene

miRTarBase miRNAs that target TMEM86B

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM86B

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for TMEM86B Gene

Localization for TMEM86B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM86B Gene

Membrane; Multi-pass membrane protein. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM86B Gene COMPARTMENTS Subcellular localization image for TMEM86B gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for TMEM86B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 21515882
GO:0016020 membrane IDA 21515882
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM86B: view

Pathways for TMEM86B Gene

SuperPathways for TMEM86B Gene

No Data Available

Interacting Proteins for TMEM86B Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000321038%0d%0a9606.ENSP00000318883%0d%0a
Selected Interacting proteins: ENSP00000321038 Q8N661-TM86B_HUMAN for TMEM86B Gene via STRING UniProtKB

Gene Ontology (GO) - Biological Process for TMEM86B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046485 ether lipid metabolic process IDA 21515882
genes like me logo Genes that share ontologies with TMEM86B: view

No data available for Pathways by source for TMEM86B Gene

Transcripts for TMEM86B Gene

mRNA/cDNA for TMEM86B Gene

(362) Selected AceView cDNA sequences:
(2) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMEM86B Gene

Transmembrane protein 86B:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM86B

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM86B Gene

No ASD Table

Relevant External Links for TMEM86B Gene

GeneLoc Exon Structure for
TMEM86B
ECgene alternative splicing isoforms for
TMEM86B

Expression for TMEM86B Gene

mRNA expression in normal human tissues for TMEM86B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TMEM86B Gene

SOURCE GeneReport for Unigene cluster for TMEM86B Gene Hs.135215

genes like me logo Genes that share expressions with TMEM86B: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TMEM86B Gene

Orthologs for TMEM86B Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM86B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM86B 35
  • 98.82 (n)
  • 97.79 (a)
TMEM86B 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM86B 35
  • 71.58 (n)
  • 57.59 (a)
TMEM86B 36
  • 56 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM86B 35
  • 74.04 (n)
  • 63.72 (a)
TMEM86B 36
  • 63 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem86b 35
  • 75.22 (n)
  • 65.93 (a)
Tmem86b 16
Tmem86b 36
  • 66 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMEM86B 36
  • 44 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM86B 36
  • 51 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem86b 35
  • 75.96 (n)
  • 69.03 (a)
lizard
(Anolis carolinensis)
Reptilia TMEM86B 36
  • 38 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii tmem86b 36
  • 30 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG7582 36
  • 28 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 28 (a)
ManyToMany
CSA.837 36
  • 24 (a)
ManyToMany
Species with no ortholog for TMEM86B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM86B Gene

ENSEMBL:
Gene Tree for TMEM86B (if available)
TreeFam:
Gene Tree for TMEM86B (if available)

Paralogs for TMEM86B Gene

Paralogs for TMEM86B Gene

Selected SIMAP similar genes for TMEM86B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TMEM86B: view

Variants for TMEM86B Gene

Sequence variations from dbSNP and Humsavar for TMEM86B Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs3745919 -- 55,227,057(+) GCAGC(A/G)GCGCC utr-variant-3-prime
rs3826884 -- 55,226,813(+) TAACA(A/G)CAACA utr-variant-3-prime
rs4255894 -- 55,228,125(+) AGGCT(C/T)CCATC intron-variant
rs4255895 -- 55,228,147(+) GCCTC(C/T)CTCAC intron-variant
rs4337407 -- 55,227,972(+) CCAGC(A/G)GGTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM86B Gene

Variant ID Type Subtype PubMed ID
nsv912454 CNV Loss 21882294
dgv4016n71 CNV Loss 21882294
nsv912457 CNV Loss 21882294

Relevant External Links for TMEM86B Gene

HapMap Linkage Disequilibrium report
TMEM86B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM86B Gene

Disorders for TMEM86B Gene

No disorders were found for TMEM86B Gene.

No data available for UniProtKB/Swiss-Prot for TMEM86B Gene

Publications for TMEM86B Gene

  1. Purification, identification, and cloning of lysoplasmalogenase, the enzyme that catalyzes hydrolysis of the vinyl ether bond of lysoplasmalogen. (PMID: 21515882) Wu L.C. … Jurkowitz M.S. (J. Biol. Chem. 2011) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 4

Products for TMEM86B Gene

Sources for TMEM86B Gene

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