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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TMEM86A Gene

protein-coding   GIFtS: 40
GCID: GC11P018714

Transmembrane Protein 86A

  Search for TMEM86A
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Transmembrane Protein 86A1 2 3
Lysoplasmalogenase-Like Protein TMEM86A2

External Ids:    HGNC: 268901   Entrez Gene: 1441102   Ensembl: ENSG000001511177   UniProtKB: Q8N2M43   

Export aliases for TMEM86A gene to outside databases

Previous GC identifers: GC11P018677 GC11P018405


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TMEM86A Gene: 
TMEM86A (transmembrane protein 86A) is a protein-coding gene. An important paralog of this gene is TMEM86B.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_009237.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TMEM86A gene promoter:
         USF1   NF-1   NF-1/L   SREBP-1c   AP-4   Tal-1beta   SREBP-1b   E47   PPAR-alpha   SREBP-1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMEM86A promoter sequence
   Search SABiosciences Chromatin IP Primers for TMEM86A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM86A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.1   Ensembl cytogenetic band:  11p15.1   HGNC cytogenetic band: 11p15.1

TMEM86A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM86A gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P018714:  view genomic region     (about GC identifiers)

Start:
18,714,669 bp from pter      End:
18,726,332 bp from pter
Size:
11,664 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TM86A_HUMAN, Q8N2M4 (See protein sequence)
Recommended Name: Lysoplasmalogenase-like protein TMEM86A  
Size: 240 amino acids; 26398 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: Q96AJ0

Explore the universe of human proteins at neXtProt for TMEM86A: NX_Q8N2M4

Explore proteomics data for TMEM86A at MOPED 

TMEM86A Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

TMEM86A Protein Expression

REFSEQ proteins: NP_699178.1  
ENSEMBL proteins: 
 ENSP00000280734  

Human Recombinant Protein Products for TMEM86A: 
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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0016021integral to membrane IEA--

TMEM86A for ontologies           About GeneDecksing



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Cloud-Clone Corp. CLIAs for TMEM86A


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
1 InterPro protein domain:
 IPR012506 YhhN

Graphical View of Domain Structure for InterPro Entry Q8N2M4

ProtoNet protein and cluster: Q8N2M4

1 Blocks protein domain: IPB012506 YhhN-like

UniProtKB/Swiss-Prot: TM86A_HUMAN, Q8N2M4
Similarity: Belongs to the TMEM86 family


TMEM86A for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Phenotypes:
     1 GenomeRNAi human phenotype for TMEM86A:
 Increased cell number in G2M,  

Animal Models:
   inGenious Targeting Laboratory - Custom generated mouse model solutions for TMEM86A 
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SwitchGear 3'UTR luciferase reporter plasmidTMEM86A 3' UTR sequence
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMEM86A

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TMEM86A (TM86A)

Search CenterWatch for drugs/clinical trials and news about TMEM86A / TM86A

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TMEM86A gene: 
NM_153347.1  

Unigene Cluster for TMEM86A:

Transmembrane protein 86A
Hs.502100  [show with all ESTs]
Unigene Representative Sequence: BC035692
5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000527002 ENST00000533987 ENST00000280734(uc001moz.1) ENST00000524888
ENST00000529240
miRNA
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SwitchGear 3'UTR luciferase reporter plasmidTMEM86A 3' UTR sequence
Inhib. RNA
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Primer
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  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM86A

Additional mRNA sequence: 

AK074600.1 BC017073.2 BC035692.1 

7 DOTS entries:

DT.97798566  DT.120711112  DT.97769486  DT.100777441  DT.40109639  DT.120711118  DT.402934 

24/100 AceView cDNA sequences (see all 100):

BX113898 AI458571 CB155586 AI269075 BG697171 AA937596 BC017073 BU608312 
BU731466 AI627820 CR595902 AI803564 BF732803 BM708740 NM_153347 AK074600 
BX478122 BQ013004 AA909022 BC035692 AW945155 BX398956 BE857577 BF195215 

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for TMEM86A    About this scheme

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b
SP1:                    -     -     -     -                                 
SP2:                                      -                                 
SP3:                    -                 -                                 
SP4:                                      -                                 
SP5:                                                                        


ECgene alternative splicing isoforms for TMEM86A

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TMEM86A expression in normal human tissues (normalized intensities)      TMEM86A embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TGAAAAATAA
TMEM86A Expression
About this image


TMEM86A expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/4 selected tissues (see all 4) fully expand
 
 Blood (Cardiovascular System)    fully expand to see all 3 entries
         Hematopoietic Stem Cells Aorta-Gonad-Mesonephros
         monocyte-derived macrophage   
 
 Lung (Respiratory System)
         bronchoalveolar lavage cells   
 
 Lateral Plate Mesoderm (Gastrulation Derivatives)
         Hematopoietic Stem Cells Aorta-Gonad-Mesonephros
 
 Ovary (Reproductive System)

 -- (Gastrointestinal Tract)
         visceral organ/oral region/gland   

See TMEM86A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TMEM86A

SOURCE GeneReport for Unigene cluster: Hs.502100
    SABiosciences Custom PCR Arrays for TMEM86A
Primer
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM86A

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for TMEM86A gene from 5/12 species (see all 12)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Tmem86a1 , 5 transmembrane protein 86A1, 5 87.36(n)1
88.75(a)1
  7 (30.68 cM)5
678931  NM_026436.31  NP_080712.11 
 470506405 
chicken
(Gallus gallus)
Aves TMEM86A1 transmembrane protein 86A 73.12(n)
74.32(a)
  428847  XM_426403.3  XP_426403.3 
lizard
(Anolis carolinensis)
Reptilia TMEM86A6
transmembrane protein 86A
74(a)
1 ↔ 1
1(67922611-67971237)
zebrafish
(Danio rerio)
Actinopterygii tmem86a1 transmembrane protein 86A 71.18(n)
73.8(a)
  541385  NM_001013512.2  NP_001013530.1 
fruit fly
(Drosophila melanogaster)
Insecta CG75821 CG7582 49.84(n)
39.15(a)
  43492  NM_143453.2  NP_651710.1 


ENSEMBL Gene Tree for TMEM86A (if available)
TreeFam Gene Tree for TMEM86A (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for TMEM86A gene
TMEM86B2  
1 SIMAP similar gene for TMEM86A using alignment to 1 protein entry:     TM86A_HUMAN:
TMEM86B

TMEM86A for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/152 SNPs in TMEM86A are shown (see all 152)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 11 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1881132041,2
--18718368(+) AGAAAC/TGAAAA 1 -- us2k10--------
rs1808782861,2
--18718464(+) CTTCTA/GCTAGC 1 -- us2k10--------
rs110247641,2
C,F--18718578(+) ACTAAG/CAATGG 1 -- us2k16Minor allele frequency- C:0.33NA WA EA 364
rs1147475301,2
F--18718617(+) TCTAGG/ACAGCA 1 -- us2k11Minor allele frequency- A:0.04WA 118
rs1165816691,2
F--18718618(+) CTAGGC/TAGCAC 1 -- us2k11Minor allele frequency- T:0.04WA 118
rs614305661,2
C--18718636(+) AGAAATG/-TGTGT 1 -- us2k11Minor allele frequency- -:0.50CSA 2
rs734264761,2
C,F--18718783(+) GAGGGG/TACTGG 1 -- us2k11Minor allele frequency- T:0.50WA 2
rs1854748891,2
--18718787(+) GGACTA/GGAGGG 1 -- us2k10--------
rs1117913421,2
F--18719009(+) TCGGTC/TTCTGC 1 -- us2k11Minor allele frequency- T:0.50CSA 2
rs1911186941,2
--18719065(+) ATGCCA/GGGATG 1 -- us2k10--------

HapMap Linkage Disequilibrium report for TMEM86A (18714669 - 18726332 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for TMEM86A:    About this table     
Variant IDTypeSubtypePubMed ID
nsv7696CNV Insertion18451855
nsv525192CNV Loss19592680
nsv897028CNV Loss21882294

SABiosciences Cancer Mutation PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for TMEM86A gene integrated from 9 sources:
(articles sorted by number of sources associating them with TMEM86A)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
  3. The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (2012)
  4. Genetic variants and environmental factors associated with hormonal markers of ovarian reserve in Caucasian and African American women . (PubMed id 22116950)1 Schuh-Huerta S.M....Reijo Pera R.A. (2012)
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
  6. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1 Otsuki T....Isogai T. (2005)
  7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 144110 HGNC: 26890 AceView: FLJ90119 Ensembl:ENSG00000151117 euGenes: HUgn144110
ECgene: TMEM86A H-InvDB: TMEM86A

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for TMEM86A Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for TMEM86A gene:
Search GeneIP for patents involving TMEM86A

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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