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TMEM86A Gene

protein-coding   GIFtS: 42
GCID: GC11P018714

Transmembrane Protein 86A

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Transmembrane Protein 86A1 2 3
Lysoplasmalogenase-Like Protein TMEM86A2

External Ids:    HGNC: 268901   Entrez Gene: 1441102   Ensembl: ENSG000001511177   UniProtKB: Q8N2M43   
ORGUL members:         

Export aliases for TMEM86A gene to outside databases

Previous GC identifers: GC11P018677 GC11P018405


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TMEM86A Gene:
TMEM86A (transmembrane protein 86A) is a protein-coding gene. An important paralog of this gene is TMEM86B.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_009237.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the TMEM86A gene promoter:
         USF1   NF-1   NF-1/L   SREBP-1c   AP-4   Tal-1beta   SREBP-1b   E47   PPAR-alpha   SREBP-1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMEM86A promoter sequence
   Search Chromatin IP Primers for TMEM86A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TMEM86A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.1   Ensembl cytogenetic band:  11p15.1   HGNC cytogenetic band: 11p15.1

TMEM86A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM86A gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P018714:  view genomic region     (about GC identifiers)

Start:
18,714,669 bp from pter      End:
18,726,332 bp from pter
Size:
11,664 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TM86A_HUMAN, Q8N2M4 (See protein sequence)
Recommended Name: Lysoplasmalogenase-like protein TMEM86A  
Size: 240 amino acids; 26398 Da
Secondary accessions: Q96AJ0

Explore the universe of human proteins at neXtProt for TMEM86A: NX_Q8N2M4

Explore proteomics data for TMEM86A at MOPED


See TMEM86A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_699178.1  
ENSEMBL proteins: 
 ENSP00000280734  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:
 IPR012506 YhhN

Graphical View of Domain Structure for InterPro Entry Q8N2M4

ProtoNet protein and cluster: Q8N2M4

1 Blocks protein domain: IPB012506 YhhN-like

UniProtKB/Swiss-Prot: TM86A_HUMAN, Q8N2M4
Similarity: Belongs to the TMEM86 family


Find genes that share domains with TMEM86A           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Phenotypes:
     1 GenomeRNAi human phenotype for TMEM86A:
 Increased cell number in G2M,  

Animal Models:
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hsa-miR-4291 hsa-miR-3607-3p hsa-miR-3194-5p hsa-miR-765 hsa-miR-29a hsa-miR-4267 hsa-miR-616 hsa-miR-548am
SwitchGear 3'UTR luciferase reporter plasmidTMEM86A 3' UTR sequence
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
TM86A_HUMAN, Q8N2M4: Membrane; Multi-pass membrane protein (Potential)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
plasma membrane3

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0016021integral component of membrane IEA--

Find genes that share ontologies with TMEM86A           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TMEM86A
Interactions:

    Search GeneGlobe Interaction Network for TMEM86A

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for TMEM86A (TM86A)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for TMEM86A gene: 
NM_153347.1  

Unigene Cluster for TMEM86A:

Transmembrane protein 86A
Hs.502100  [show with all ESTs]
Unigene Representative Sequence: BC035692
5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000527002 ENST00000533987 ENST00000280734(uc001moz.1) ENST00000524888
ENST00000529240
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SwitchGear 3'UTR luciferase reporter plasmidTMEM86A 3' UTR sequence
Inhib. RNA
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  QuantiFast Probe-based Assays in human, mouse, rat TMEM86A

Additional mRNA sequence: 

AK074600.1 BC017073.2 BC035692.1 

7 DOTS entries:

DT.97798566  DT.120711112  DT.97769486  DT.100777441  DT.40109639  DT.120711118  DT.402934 

Selected AceView cDNA sequences (see all 100):

NM_153347 BC017073 BF732803 BU731466 BF195215 BX113898 CB155586 BG697171 
AI690132 CR595902 AK074600 AI493942 BU608312 BX478122 BQ881792 AA909022 
BC035692 AI269075 AI803564 BX398956 BQ013004 AA937596 AW945155 AI627820 

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for TMEM86A    About this scheme

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b
SP1:                    -     -     -     -                                 
SP2:                                      -                                 
SP3:                    -                 -                                 
SP4:                                      -                                 
SP5:                                                                        


ECgene alternative splicing isoforms for TMEM86A

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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TMEM86A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TGAAAAATAA
TMEM86A Expression
About this image


TMEM86A expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 3) fully expand
 
 Ovary (Reproductive System)
         Mature follicles
 
 Blood (Cardiovascular System)
         Hematopoietic Stem Cells Aorta-Gonad-Mesonephros
 
 Lateral Plate Mesoderm (Gastrulation Derivatives)
         Hematopoietic Stem Cells Aorta-Gonad-Mesonephros
TMEM86A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

TMEM86A Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.502100
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM86A

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for TMEM86A gene from Selected species (see all 13)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Tmem86a1 , 5 transmembrane protein 86A1, 5 87.36(n)1
88.75(a)1
  7 (30.68 cM)5
678931  NM_026436.31  NP_080712.11 
 470506405 
chicken
(Gallus gallus)
Aves TMEM86A1 transmembrane protein 86A 72.77(n)
73.19(a)
  428847  XM_426403.4  XP_426403.4 
lizard
(Anolis carolinensis)
Reptilia TMEM86A6
transmembrane protein 86A
74(a)
1 ↔ 1
1(67922611-67971237)
tropical clawed frog
(Xenopus tropicalis)
Amphibia LOC1001353561 uncharacterized LOC100135356 71.87(n)
73.42(a)
  100135356  NM_001114030.1  NP_001107502.1 
zebrafish
(Danio rerio)
Actinopterygii tmem86a1 transmembrane protein 86A 70.35(n)
71.91(a)
  541385  NM_001013512.2  NP_001013530.1 
fruit fly
(Drosophila melanogaster)
Insecta CG75821 CG7582 49.53(n)
39.62(a)
  43492  NM_143453.2  NP_651710.1 


ENSEMBL Gene Tree for TMEM86A (if available)
TreeFam Gene Tree for TMEM86A (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for TMEM86A gene
TMEM86B2  
1 SIMAP similar gene for TMEM86A using alignment to 1 protein entry:     TM86A_HUMAN:
TMEM86B

Find genes that share paralogs with TMEM86A           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for TMEM86A (see all 152)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 11 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1881132041,2
--18718368(+) AGAAAC/TGAAAA 1 -- us2k10--------
rs1808782861,2
--18718464(+) CTTCTA/GCTAGC 1 -- us2k10--------
rs110247641,2
C,F--18718578(+) ACTAAG/CAATGG 1 -- us2k16Minor allele frequency- C:0.33NA WA EA 364
rs1147475301,2
F--18718617(+) TCTAGG/ACAGCA 1 -- us2k11Minor allele frequency- A:0.04WA 118
rs1165816691,2
F--18718618(+) CTAGGC/TAGCAC 1 -- us2k11Minor allele frequency- T:0.04WA 118
rs614305661,2
C--18718636(+) AGAAATG/-TGTGT 1 -- us2k11Minor allele frequency- -:0.50CSA 2
rs734264761,2
C,F--18718783(+) GAGGGG/TACTGG 1 -- us2k11Minor allele frequency- T:0.50WA 2
rs1854748891,2
--18718787(+) GGACTA/GGAGGG 1 -- us2k10--------
rs1117913421,2
F--18719009(+) TCGGTC/TTCTGC 1 -- us2k11Minor allele frequency- T:0.50CSA 2
rs1911186941,2
--18719065(+) ATGCCA/GGGATG 1 -- us2k10--------

HapMap Linkage Disequilibrium report for TMEM86A (18714669 - 18726332 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for TMEM86A:    About this table    
Variant IDTypeSubtypePubMed ID
nsv7696CNV Insertion18451855
nsv525192CNV Loss19592680
nsv897028CNV Loss21882294

Site Specific Mutation Identification with PCR Assays
Search QIAGEN SeqTarget long-range PCR primers for resequencing TMEM86A
DNA2.0 Custom Variant and Variant Library Synthesis for TMEM86A

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for TMEM86A gene integrated from 10 sources:
(articles sorted by number of sources associating them with TMEM86A)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  3. The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (J. Cell. Sci. 2012)
  4. Genetic variants and environmental factors associated with hormonal markers of ovarian reserve in Caucasian and African American women. (PubMed id 22116950)1 Schuh-Huerta S.M....Reijo Pera R.A. (Hum. Reprod. 2012)
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)
  6. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1 Otsuki T....Isogai T. (DNA Res. 2005)
  7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 144110 HGNC: 26890 AceView: FLJ90119 Ensembl:ENSG00000151117 euGenes: HUgn144110
ECgene: TMEM86A H-InvDB: TMEM86A

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for TMEM86A Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for TMEM86A gene:
Search GeneIP for patents involving TMEM86A

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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 Search Tocris compounds for TMEM86A (TM86A)
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 Search Addgene for plasmids for TMEM86A
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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