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Aliases for TMEM86A Gene

Aliases for TMEM86A Gene

  • Transmembrane Protein 86A 2 3 4 5

External Ids for TMEM86A Gene

Previous GeneCards Identifiers for TMEM86A Gene

  • GC11P018677
  • GC11P018405
  • GC11P018714

Summaries for TMEM86A Gene

GeneCards Summary for TMEM86A Gene

TMEM86A (Transmembrane Protein 86A) is a Protein Coding gene. An important paralog of this gene is TMEM86B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM86A Gene

Genomics for TMEM86A Gene

Regulatory Elements for TMEM86A Gene

Enhancers for TMEM86A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around TMEM86A on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM86A Gene

18,693,122 bp from pter
18,704,785 bp from pter
11,664 bases
Plus strand

Genomic View for TMEM86A Gene

Genes around TMEM86A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM86A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM86A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM86A Gene

Proteins for TMEM86A Gene

  • Protein details for TMEM86A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Lysoplasmalogenase-like protein TMEM86A
    Protein Accession:
    Secondary Accessions:
    • Q96AJ0

    Protein attributes for TMEM86A Gene

    240 amino acids
    Molecular mass:
    26398 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM86A Gene

Post-translational modifications for TMEM86A Gene

No Post-translational modifications

Other Protein References for TMEM86A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM86A Gene

Domains & Families for TMEM86A Gene

Protein Domains for TMEM86A Gene


Suggested Antigen Peptide Sequences for TMEM86A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TMEM86 family.
  • Belongs to the TMEM86 family.
genes like me logo Genes that share domains with TMEM86A: view

No data available for Gene Families for TMEM86A Gene

Function for TMEM86A Gene

genes like me logo Genes that share phenotypes with TMEM86A: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM86A Gene

Localization for TMEM86A Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM86A Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for TMEM86A Gene COMPARTMENTS Subcellular localization image for TMEM86A gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for TMEM86A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM86A: view

Pathways & Interactions for TMEM86A Gene

SuperPathways for TMEM86A Gene

No Data Available

Interacting Proteins for TMEM86A Gene

Gene Ontology (GO) - Biological Process for TMEM86A Gene


No data available for Pathways by source and SIGNOR curated interactions for TMEM86A Gene

Drugs & Compounds for TMEM86A Gene

No Compound Related Data Available

Transcripts for TMEM86A Gene

mRNA/cDNA for TMEM86A Gene

Unigene Clusters for TMEM86A Gene

Transmembrane protein 86A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM86A Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b
SP1: - - - -
SP2: -
SP3: - -
SP4: -

Relevant External Links for TMEM86A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM86A Gene

mRNA expression in normal human tissues for TMEM86A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM86A Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x5.0).

NURSA nuclear receptor signaling pathways regulating expression of TMEM86A Gene:


SOURCE GeneReport for Unigene cluster for TMEM86A Gene:

genes like me logo Genes that share expression patterns with TMEM86A: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for TMEM86A Gene

Orthologs for TMEM86A Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM86A Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TMEM86A 34
  • 88.89 (n)
  • 88.75 (a)
TMEM86A 35
  • 87 (a)
(Canis familiaris)
Mammalia TMEM86A 34
  • 91.81 (n)
  • 92.08 (a)
TMEM86A 35
  • 76 (a)
(Mus musculus)
Mammalia Tmem86a 34
  • 87.36 (n)
  • 88.75 (a)
Tmem86a 16
Tmem86a 35
  • 88 (a)
(Pan troglodytes)
Mammalia TMEM86A 34
  • 99.58 (n)
  • 99.17 (a)
TMEM86A 35
  • 99 (a)
(Rattus norvegicus)
Mammalia Tmem86a 34
  • 85.63 (n)
  • 87.45 (a)
(Monodelphis domestica)
Mammalia TMEM86A 35
  • 67 (a)
(Gallus gallus)
Aves TMEM86A 34
  • 72.77 (n)
  • 73.19 (a)
TMEM86A 35
  • 70 (a)
(Anolis carolinensis)
Reptilia TMEM86A 35
  • 74 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100135356 34
  • 71.87 (n)
  • 73.42 (a)
(Danio rerio)
Actinopterygii tmem86a 34
  • 70.35 (n)
  • 71.91 (a)
tmem86a 35
  • 71 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010616 34
  • 42.77 (n)
  • 35.4 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7582 34
  • 49.53 (n)
  • 39.62 (a)
CG7582 35
  • 31 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 33 (a)
CSA.837 35
  • 30 (a)
Species where no ortholog for TMEM86A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM86A Gene

Gene Tree for TMEM86A (if available)
Gene Tree for TMEM86A (if available)

Paralogs for TMEM86A Gene

Paralogs for TMEM86A Gene

(1) SIMAP similar genes for TMEM86A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TMEM86A: view

Variants for TMEM86A Gene

Sequence variations from dbSNP and Humsavar for TMEM86A Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs7945285 - 18,701,930(+) CTATG(C/T)GGCCC reference, missense
rs1020408 -- 18,700,463(-) AGGCA(A/G)TGGCA intron-variant
rs1530566 -- 18,700,611(-) CCCCC(A/C)GCTGT intron-variant
rs7946446 -- 18,698,757(+) AACCC(C/G)GGCGC utr-variant-5-prime
rs7950030 -- 18,699,431(+) ATCCC(C/G)TGCTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM86A Gene

Variant ID Type Subtype PubMed ID
nsv525192 CNV loss 19592680
nsv553633 CNV gain 21841781
nsv7696 CNV insertion 18451855

Variation tolerance for TMEM86A Gene

Residual Variation Intolerance Score: 45.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.61; 56.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM86A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM86A Gene

Disorders for TMEM86A Gene

Relevant External Links for TMEM86A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TMEM86A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM86A Gene

Publications for TMEM86A Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  3. Genetic variants and environmental factors associated with hormonal markers of ovarian reserve in Caucasian and African American women. (PMID: 22116950) Schuh-Huerta S.M. … Reijo Pera R.A. (Hum. Reprod. 2012) 3 65
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3 65
  5. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 65

Products for TMEM86A Gene

Sources for TMEM86A Gene

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