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Aliases for TMEM86A Gene

Aliases for TMEM86A Gene

  • Transmembrane Protein 86A 2 3 4

External Ids for TMEM86A Gene

Previous GeneCards Identifiers for TMEM86A Gene

  • GC11P018677
  • GC11P018405

Summaries for TMEM86A Gene

GeneCards Summary for TMEM86A Gene

TMEM86A is a Protein Coding gene. An important paralog of this gene is TMEM86B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM86A Gene

Genomics for TMEM86A Gene

Regulatory Elements for TMEM86A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TMEM86A Gene

18,693,122 bp from pter
18,704,785 bp from pter
11,664 bases
Plus strand

Genomic View for TMEM86A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM86A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM86A Gene

Proteins for TMEM86A Gene

  • Protein details for TMEM86A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Lysoplasmalogenase-like protein TMEM86A
    Protein Accession:
    Secondary Accessions:
    • Q96AJ0

    Protein attributes for TMEM86A Gene

    240 amino acids
    Molecular mass:
    26398 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM86A Gene

Proteomics data for TMEM86A Gene at MOPED

Post-translational modifications for TMEM86A Gene

No Post-translational modifications

Other Protein References for TMEM86A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM86A Gene

Domains for TMEM86A Gene

Protein Domains for TMEM86A Gene


Suggested Antigen Peptide Sequences for TMEM86A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TMEM86 family.
  • Belongs to the TMEM86 family.
genes like me logo Genes that share domains with TMEM86A: view

No data available for Gene Families for TMEM86A Gene

Function for TMEM86A Gene

Phenotypes for TMEM86A Gene

GenomeRNAi human phenotypes for TMEM86A:
genes like me logo Genes that share phenotypes with TMEM86A: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM86A

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMEM86A Gene

Localization for TMEM86A Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM86A Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for TMEM86A Gene COMPARTMENTS Subcellular localization image for TMEM86A gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for TMEM86A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM86A: view

Pathways for TMEM86A Gene

SuperPathways for TMEM86A Gene

No Data Available

Interacting Proteins for TMEM86A Gene

Gene Ontology (GO) - Biological Process for TMEM86A Gene


No data available for Pathways by source for TMEM86A Gene

Transcripts for TMEM86A Gene

mRNA/cDNA for TMEM86A Gene

Unigene Clusters for TMEM86A Gene

Transmembrane protein 86A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM86A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM86A Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b
SP1: - - - -
SP2: -
SP3: - -
SP4: -

Relevant External Links for TMEM86A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM86A Gene

mRNA expression in normal human tissues for TMEM86A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM86A Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (5.0).

SOURCE GeneReport for Unigene cluster for TMEM86A Gene Hs.502100

genes like me logo Genes that share expressions with TMEM86A: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for TMEM86A Gene

Orthologs for TMEM86A Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM86A Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TMEM86A 35
  • 88.89 (n)
  • 88.75 (a)
TMEM86A 36
  • 87 (a)
(Canis familiaris)
Mammalia TMEM86A 35
  • 91.81 (n)
  • 92.08 (a)
TMEM86A 36
  • 76 (a)
(Mus musculus)
Mammalia Tmem86a 35
  • 87.36 (n)
  • 88.75 (a)
Tmem86a 16
Tmem86a 36
  • 88 (a)
(Pan troglodytes)
Mammalia TMEM86A 35
  • 99.58 (n)
  • 99.17 (a)
TMEM86A 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Tmem86a 35
  • 85.63 (n)
  • 87.45 (a)
(Monodelphis domestica)
Mammalia TMEM86A 36
  • 67 (a)
(Gallus gallus)
Aves TMEM86A 35
  • 72.77 (n)
  • 73.19 (a)
TMEM86A 36
  • 70 (a)
(Anolis carolinensis)
Reptilia TMEM86A 36
  • 74 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100135356 35
  • 71.87 (n)
  • 73.42 (a)
(Danio rerio)
Actinopterygii tmem86a 35
  • 70.35 (n)
  • 71.91 (a)
tmem86a 36
  • 71 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010616 35
  • 42.77 (n)
  • 35.4 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7582 35
  • 49.53 (n)
  • 39.62 (a)
CG7582 36
  • 31 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 33 (a)
CSA.837 36
  • 30 (a)
Species with no ortholog for TMEM86A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM86A Gene

Gene Tree for TMEM86A (if available)
Gene Tree for TMEM86A (if available)

Paralogs for TMEM86A Gene

Paralogs for TMEM86A Gene

(1) SIMAP similar genes for TMEM86A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TMEM86A: view

Variants for TMEM86A Gene

Sequence variations from dbSNP and Humsavar for TMEM86A Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs14792 -- 18,703,011(+) CACTC(C/T)GGGGT utr-variant-3-prime
rs733460 -- 18,701,244(-) CTCTA(C/T)CCCCC intron-variant
rs1020408 -- 18,700,463(-) AGGCA(A/G)TGGCA intron-variant
rs1530566 -- 18,700,611(-) CCCCC(A/C)GCTGT intron-variant
rs4237725 -- 18,697,725(+) ACCTA(C/T)ACATG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TMEM86A Gene

Variant ID Type Subtype PubMed ID
nsv7696 CNV Insertion 18451855
nsv897028 CNV Loss 21882294
nsv525192 CNV Loss 19592680

Relevant External Links for TMEM86A Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM86A Gene

Disorders for TMEM86A Gene

No disorders were found for TMEM86A Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for TMEM86A Gene

Publications for TMEM86A Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3
  5. Genetic variants and environmental factors associated with hormonal markers of ovarian reserve in Caucasian and African American women. (PMID: 22116950) Schuh-Huerta S.M. … Reijo Pera R.A. (Hum. Reprod. 2012) 3

Products for TMEM86A Gene

Sources for TMEM86A Gene

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