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Aliases for TMEM86A Gene

Aliases for TMEM86A Gene

  • Transmembrane Protein 86A 2 3 4 5

External Ids for TMEM86A Gene

Previous GeneCards Identifiers for TMEM86A Gene

  • GC11P018677
  • GC11P018405
  • GC11P018714

Summaries for TMEM86A Gene

GeneCards Summary for TMEM86A Gene

TMEM86A (Transmembrane Protein 86A) is a Protein Coding gene. An important paralog of this gene is TMEM86B.

Additional gene information for TMEM86A Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM86A Gene

Genomics for TMEM86A Gene

Regulatory Elements for TMEM86A Gene

Enhancers for TMEM86A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H018668 0.7 ENCODE 20.6 -24.4 -24434 0 BCOR CTCF RNF2 REST RAD21 MTA3 SMARCA4 ZNF341 IKZF1 ADNP TMEM86A SPTY2D1 LOC105376579 IGSF22 LOC100129966 SPTY2D1-AS1 LOC100506569
GH11H018578 1.2 Ensembl ENCODE 10.4 -113.8 -113795 1 HDAC1 PKNOX1 FOXA2 ATF1 SIN3A BATF GATA2 ZNF207 FOS RCOR1 LOC100129966 SPTY2D1 TMEM86A LOC105376579 IGSF22 TSG101 SERGEF SPTY2D1-AS1 ENSG00000274589
GH11H018670 1 Ensembl ENCODE 12 -23.6 -23625 0 SMARCE1 PKNOX1 ETV1 USF2 DPF2 CEBPG FOSL1 JUND GATA3 ZNF316 TMEM86A SPTY2D1 LOC105376579 IGSF22 LOC100129966 SPTY2D1-AS1 LOC100506569
GH11H018697 1 ENCODE 8.1 +6.2 6151 3 ATF1 SIN3A BRCA1 GLIS2 ATF7 SP3 SP5 NFYC REST MIER3 GTF2H1 SPTY2D1 SAAL1 HPS5 TMEM86A IGSF22 LOC105376579 YWHABP2 UEVLD PIR46171
GH11H018669 0.5 ENCODE 12 -23.2 -23214 0 CREB1 CEBPG ATF7 ATF2 TMEM86A SPTY2D1 LOC105376579 IGSF22 LOC100129966 SPTY2D1-AS1 LOC100506569
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM86A on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM86A Gene

Chromosome:
11
Start:
18,693,122 bp from pter
End:
18,704,785 bp from pter
Size:
11,664 bases
Orientation:
Plus strand

Genomic View for TMEM86A Gene

Genes around TMEM86A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM86A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM86A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM86A Gene

Proteins for TMEM86A Gene

  • Protein details for TMEM86A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N2M4-TM86A_HUMAN
    Recommended name:
    Lysoplasmalogenase-like protein TMEM86A
    Protein Accession:
    Q8N2M4
    Secondary Accessions:
    • Q96AJ0

    Protein attributes for TMEM86A Gene

    Size:
    240 amino acids
    Molecular mass:
    26398 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM86A Gene

Post-translational modifications for TMEM86A Gene

No Post-translational modifications

Other Protein References for TMEM86A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM86A Gene

Domains & Families for TMEM86A Gene

Gene Families for TMEM86A Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TMEM86A Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM86A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N2M4

UniProtKB/Swiss-Prot:

TM86A_HUMAN :
  • Belongs to the TMEM86 family.
Family:
  • Belongs to the TMEM86 family.
genes like me logo Genes that share domains with TMEM86A: view

Function for TMEM86A Gene

Phenotypes From GWAS Catalog for TMEM86A Gene

genes like me logo Genes that share phenotypes with TMEM86A: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TMEM86A
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM86A Gene

Localization for TMEM86A Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM86A Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM86A gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for TMEM86A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM86A: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TMEM86A Gene

Pathways & Interactions for TMEM86A Gene

SuperPathways for TMEM86A Gene

No Data Available

Interacting Proteins for TMEM86A Gene

Gene Ontology (GO) - Biological Process for TMEM86A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM86A Gene

Drugs & Compounds for TMEM86A Gene

No Compound Related Data Available

Transcripts for TMEM86A Gene

Unigene Clusters for TMEM86A Gene

Transmembrane protein 86A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TMEM86A
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM86A Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b
SP1: - - - -
SP2: -
SP3: - -
SP4: -
SP5:

Relevant External Links for TMEM86A Gene

GeneLoc Exon Structure for
TMEM86A
ECgene alternative splicing isoforms for
TMEM86A

Expression for TMEM86A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM86A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM86A Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x5.0).

NURSA nuclear receptor signaling pathways regulating expression of TMEM86A Gene:

TMEM86A

SOURCE GeneReport for Unigene cluster for TMEM86A Gene:

Hs.502100

Evidence on tissue expression from TISSUES for TMEM86A Gene

  • Intestine(4)
genes like me logo Genes that share expression patterns with TMEM86A: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM86A Gene

Orthologs for TMEM86A Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM86A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM86A 33 34
  • 99.58 (n)
dog
(Canis familiaris)
Mammalia TMEM86A 33 34
  • 91.81 (n)
cow
(Bos Taurus)
Mammalia TMEM86A 33 34
  • 88.89 (n)
mouse
(Mus musculus)
Mammalia Tmem86a 33 16 34
  • 87.36 (n)
rat
(Rattus norvegicus)
Mammalia Tmem86a 33
  • 85.63 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM86A 34
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM86A 33 34
  • 72.77 (n)
lizard
(Anolis carolinensis)
Reptilia TMEM86A 34
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100135356 33
  • 71.87 (n)
zebrafish
(Danio rerio)
Actinopterygii tmem86a 33 34
  • 70.35 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG7582 33 34
  • 49.53 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010616 33
  • 42.77 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 33 (a)
ManyToMany
CSA.837 34
  • 30 (a)
ManyToMany
Species where no ortholog for TMEM86A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM86A Gene

ENSEMBL:
Gene Tree for TMEM86A (if available)
TreeFam:
Gene Tree for TMEM86A (if available)

Paralogs for TMEM86A Gene

Paralogs for TMEM86A Gene

(1) SIMAP similar genes for TMEM86A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TMEM86A: view

Variants for TMEM86A Gene

Sequence variations from dbSNP and Humsavar for TMEM86A Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000613868 -- 18,699,299(+) CAGGG(A/G)CCTCC intron-variant
rs1001396426 -- 18,703,020(+) GTTTT(A/G)AGACC utr-variant-3-prime
rs1001686025 -- 18,697,155(+) GGTAA(C/G)GTGCT upstream-variant-2KB
rs1001759657 -- 18,697,554(+) TTAGG(A/G)CTGGT upstream-variant-2KB
rs1001790798 -- 18,697,963(+) ATCCA(C/T)TTGGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TMEM86A Gene

Variant ID Type Subtype PubMed ID
nsv525192 CNV loss 19592680
nsv553633 CNV gain 21841781
nsv7696 CNV insertion 18451855

Variation tolerance for TMEM86A Gene

Residual Variation Intolerance Score: 45.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.61; 56.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM86A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM86A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM86A Gene

Disorders for TMEM86A Gene

Relevant External Links for TMEM86A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM86A

No disorders were found for TMEM86A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM86A Gene

Publications for TMEM86A Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. Genetic variants and environmental factors associated with hormonal markers of ovarian reserve in Caucasian and African American women. (PMID: 22116950) Schuh-Huerta SM … Reijo Pera RA (Human reproduction (Oxford, England) 2012) 3 60
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P … Vidal M (Genomics 2007) 3 60
  5. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3 60

Products for TMEM86A Gene

Sources for TMEM86A Gene

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