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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TMEM86A Gene

protein-coding GIFtS: 40
GCID: GC11P018714

transmembrane protein 86A

Search for TMEM86A
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Transmembrane Protein 86A¹ ² ³
FLJ90119¹
Lysoplasmalogenase-Like Protein TMEM86A²

External Ids:	HGNC: 26890¹	Entrez Gene: 144110²	Ensembl: ENSG00000151117⁷	UniProtKB: Q8N2M4³

Export aliases for TMEM86A gene to outside databases

Previous GC identifers: GC11P018677 GC11P018405

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_009237.18

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TMEM86A gene promoter:
USF1 NF-1 NF-1/L SREBP-1c AP-4 Tal-1beta SREBP-1b E47 PPAR-alpha SREBP-1a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TMEM86A promoter sequence

Search SABiosciences Chromatin IP Primers for TMEM86A

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM86A

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.1 Ensembl cytogenetic band: 11p15.1 HGNC cytogenetic band: 11p15.1

TMEM86A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM86A gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P018714: view genomic region (about GC identifiers)

Start:	18,714,669 bp from pter	End:	18,726,332 bp from pter
Size:	11,664 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TM86A_HUMAN, Q8N2M4 (See protein sequence)

Recommended Name: Lysoplasmalogenase-like protein TMEM86A

Size: 240 amino acids; 26398 Da

Subcellular location: Membrane; Multi-pass membrane protein (Potential)

Secondary accessions: Q96AJ0

Explore the universe of human proteins at neXtProt for TMEM86A: NX_Q8N2M4

TMEM86A Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_699178.1

ENSEMBL proteins:

ENSP00000280734 ENSP00000441843

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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016021	integral to membrane	IEA	--

TMEM86A for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TMEM86A for domains About GeneDecksing

1 InterPro domain/family:

IPR012506 YhhN

Graphical View of Domain Structure for InterPro Entry Q8N2M4

ProtoNet protein and cluster: Q8N2M4

1 Blocks protein family: IPB012506 YhhN-like

UniProtKB/Swiss-Prot: TM86A_HUMAN, Q8N2M4

Similarity: Belongs to the TMEM86 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

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1 GenomeRNAi human phenotype for TMEM86A:

Increased cell number in G2M,

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for TMEM86A

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

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Browse Tocris compounds for TMEM86A
Search CenterWatch for drugs/clinical trials and news about TMEM86A / TM86A

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for TMEM86A gene:

NM_153347.1

Unigene Cluster for TMEM86A:

Transmembrane protein 86A

Hs.502100 [show with all ESTs]

Unigene Representative Sequence: BC035692

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000527002 ENST00000533987 ENST00000280734(uc001moz.1) ENST00000524888

ENST00000529240 ENST00000535380

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Additional cDNA sequence:

AK074600.1 BC017073.2 BC035692.1

7 DOTS entries:

DT.97798566 DT.120711112 DT.97769486 DT.100777441 DT.40109639 DT.120711118 DT.402934

24/100 AceView cDNA sequences (see all 100):

BM708740 BX113898 AI269075 BQ013004 BU608312 BC035692 BE857577 BF195215

BX398956 AK074600 AI803564 AI690132 BC017073 AW016649 CR595902 AW945155

AA909022 AI627820 AI493942 AI458571 BQ881792 BX478122 NM_153347 BG697171

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for TMEM86A About this scheme

ExUns:	1a	·	1b	·	1c	^	2a	·	2b	·	2c	^	3	^	4a	·	4b	·	4c	^	5a	·	5b
SP1:							-		-		-		-
SP2:													-
SP3:							-						-
SP4:													-
SP5:

ECgene alternative splicing isoforms for TMEM86A

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TMEM86A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGAAAAATAA

About this image

TMEM86A expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Mature follicles (In-vitro growth and ...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See TMEM86A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TMEM86A

SOURCE GeneReport for Unigene cluster: Hs.502100

SABiosciences Custom PCR Arrays for TMEM86A

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for TMEM86A gene from 4/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	TMEM86A¹	transmembrane protein 86A	73.12(n) 74.32(a)		428847 XM_426403.3 XP_426403.3
lizard (Anolis carolinensis)	Reptilia	TMEM86A⁶	--	72(a)	1 ↔ 1	1(67965778-67971237)
zebrafish (Danio rerio)	Actinopterygii	tmem86a¹	transmembrane protein 86A	71.18(n) 73.8(a)		541385 NM_001013512.2 NP_001013530.1
fruit fly (Drosophila melanogaster)	Insecta	CG7582¹	CG7582	49.84(n) 39.15(a)		43492 NM_143453.2 NP_651710.1

ENSEMBL Gene Tree for TMEM86A (if available)
TreeFam Gene Tree for TMEM86A (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for TMEM86A gene

TMEM86B²

1 SIMAP similar gene for TMEM86A using alignment to 1 protein entry: TM86A_HUMAN:

TMEM86B

TMEM86A for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs188113204^1,2		--	18718368(+)	`AGAAAC/TGAAAA`	1	--	us2k¹		0	--	--	--	--
rs180878286^1,2		--	18718464(+)	`CTTCTA/GCTAGC`	1	--	us2k¹		0	--	--	--	--
rs11024764^1,2	C,F,	--	18718578(+)	`ACTAAG/CAATGG`	1	--	us2k¹		6		NA WA EA	364
rs114747530^1,2	F,	--	18718617(+)	`TCTAGG/ACAGCA`	1	--	us2k¹		1		WA	118
rs116581669^1,2	F,	--	18718618(+)	`CTAGGC/TAGCAC`	1	--	us2k¹		1		WA	118
rs61430566^1,2	C,	--	18718636(+)	`AGAAATG/-TGTGT`	1	--	us2k¹		1		CSA	2
rs73426476^1,2	C,	--	18718783(+)	`GAGGGG/TACTGG`	1	--	us2k¹		1		WA	2
rs185474889^1,2		--	18718787(+)	`GGACTA/GGAGGG`	1	--	us2k¹		0	--	--	--	--
rs111791342^1,2		--	18719009(+)	`TCGGTC/TTCTGC`	1	--	us2k¹		1		CSA	2
rs191118694^1,2		--	18719065(+)	`ATGCCA/GGGATG`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for TMEM86A (18714669 - 18726332 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TMEM86A: --

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TMEM86A gene integrated from 9 sources:
(articles sorted by number of sources associating them with TMEM86A)

Utopia: connect your pdf to the dynamic
world of online information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)¹ Aichem A....Groettrup M. (2012)
Genetic variants and environmental factors associated with hormonal markers of ovarian reserve in Caucasian and African American women . (PubMed id 22116950)¹ Schuh-Huerta S.M....Reijo Pera R.A. (2012)
hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)¹ Lamesch P.... Vidal M. (2007)
Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)¹ Otsuki T....Isogai T. (2005)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 144110	HGNC: 26890	AceView: FLJ90119	Ensembl:ENSG00000151117	euGenes: HUgn144110
ECgene: TMEM86A	H-InvDB: TMEM86A

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for TMEM86A	Pharmacogenomics, SNPs, Pathways

Intellectual Property for TMEM86A gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for TMEM86A gene:
Search GeneIP for patents involving TMEM86A

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


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GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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TMEM86A Gene

transmembrane protein 86A

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TMEM86A Gene

transmembrane protein 86A

Aliasesfor TMEM86A gene

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Genomic Viewsfor TMEM86A gene

Proteinsfor TMEM86A gene

Protein Domains /Familiesfor TMEM86A gene

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for TMEM86A gene

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for TMEM86A gene

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for TMEM86A gene

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for TMEM86A gene

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