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Aliases for TMEM81 Gene

Aliases for TMEM81 Gene

  • Transmembrane Protein 81 2 3 5
  • KVLA2788 3
  • UNQ2788 3
  • HC3107 3

External Ids for TMEM81 Gene

Previous GeneCards Identifiers for TMEM81 Gene

  • GC01M203318
  • GC01M176217

Summaries for TMEM81 Gene

GeneCards Summary for TMEM81 Gene

TMEM81 (Transmembrane Protein 81) is a Protein Coding gene.

Additional gene information for TMEM81 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM81 Gene

Genomics for TMEM81 Gene

GeneHancer (GH) Regulatory Elements for TMEM81 Gene

Promoters and enhancers for TMEM81 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I205084 Promoter 0.5 EPDnew 550.8 0.0 -14 0.1 TMEM81 PIR55431
GH01I205246 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.3 -164.5 -164527 5.1 HDGF HDAC1 ATF1 ZNF335 TCF12 GLIS2 ATF7 CREM PHF21A CEBPB TMCC2 DSTYK CNTN2 CDK18 NUAK2 TMEM81 LOC101929459 NFASC MFSD4A PIR41674
GH01I205120 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE 6.1 -37.3 -37337 2.9 CLOCK ZFP64 FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 RBBP5 MDM4 PPP1R15B ELK4 TMCC2 DSTYK RPL13AP11 NFASC SNRPGP10 LOC101929459
GH01I205310 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 4.4 -232.1 -232065 11.8 HDGF PKNOX1 FOXA2 ARID4B SIN3A FEZF1 DMAP1 YBX1 ZNF2 ZBTB7B NUAK2 ELK4 LOC101929459 KLHDC8A CNTN2 TMEM81 RBBP5 PIR41674
GH01I205010 Enhancer 0.6 dbSUPER 15.4 +67.4 67392 12.8 ZNF263 ZBTB6 NFIB GATAD2B ZIC2 ZFHX2 NFIC ZNF24 ZBTB33 PRDM10 CNTN2 TMEM81 MFSD4A DSTYK GC01P205019 RPL13AP11 NFASC
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TMEM81 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TMEM81 gene promoter:

Genomic Locations for TMEM81 Gene

Genomic Locations for TMEM81 Gene
chr1:205,083,129-205,084,460
(GRCh38/hg38)
Size:
1,332 bases
Orientation:
Minus strand
chr1:205,052,257-205,053,645
(GRCh37/hg19)

Genomic View for TMEM81 Gene

Genes around TMEM81 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM81 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM81 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM81 Gene

Proteins for TMEM81 Gene

  • Protein details for TMEM81 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P7N7-TMM81_HUMAN
    Recommended name:
    Transmembrane protein 81
    Protein Accession:
    Q6P7N7
    Secondary Accessions:
    • Q6UVZ4

    Protein attributes for TMEM81 Gene

    Size:
    255 amino acids
    Molecular mass:
    28468 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM81 Gene

Post-translational modifications for TMEM81 Gene

Other Protein References for TMEM81 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM81 Gene

Domains & Families for TMEM81 Gene

Gene Families for TMEM81 Gene

Protein Domains for TMEM81 Gene

Suggested Antigen Peptide Sequences for TMEM81 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM81: view

No data available for UniProtKB/Swiss-Prot for TMEM81 Gene

Function for TMEM81 Gene

Phenotypes From GWAS Catalog for TMEM81 Gene

genes like me logo Genes that share phenotypes with TMEM81: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM81 Gene

Localization for TMEM81 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM81 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM81 gene
Compartment Confidence
plasma membrane 3
extracellular 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Intermediate filaments (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TMEM81 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM81: view

Pathways & Interactions for TMEM81 Gene

SuperPathways for TMEM81 Gene

No Data Available

Interacting Proteins for TMEM81 Gene

Gene Ontology (GO) - Biological Process for TMEM81 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM81 Gene

Drugs & Compounds for TMEM81 Gene

No Compound Related Data Available

Transcripts for TMEM81 Gene

mRNA/cDNA for TMEM81 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(20) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMEM81 Gene

Transmembrane protein 81:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM81 Gene

No ASD Table

Relevant External Links for TMEM81 Gene

GeneLoc Exon Structure for
TMEM81
ECgene alternative splicing isoforms for
TMEM81

Expression for TMEM81 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM81 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM81 Gene



NURSA nuclear receptor signaling pathways regulating expression of TMEM81 Gene:

TMEM81

SOURCE GeneReport for Unigene cluster for TMEM81 Gene:

Hs.146928

Evidence on tissue expression from TISSUES for TMEM81 Gene

  • Nervous system(4)
genes like me logo Genes that share expression patterns with TMEM81: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM81 Gene

Orthologs for TMEM81 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM81 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM81 33 34
  • 98.95 (n)
cow
(Bos Taurus)
Mammalia TMEM81 33 34
  • 84.95 (n)
dog
(Canis familiaris)
Mammalia TMEM81 33 34
  • 80.82 (n)
mouse
(Mus musculus)
Mammalia Tmem81 33 16 34
  • 77.38 (n)
rat
(Rattus norvegicus)
Mammalia Tmem81 33
  • 77.38 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM81 34
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM81 34
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM81 33 34
  • 55.56 (n)
lizard
(Anolis carolinensis)
Reptilia TMEM81 34
  • 42 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101730568 33
  • 44.93 (n)
zebrafish
(Danio rerio)
Actinopterygii TMEM81 34
  • 27 (a)
OneToOne
Species where no ortholog for TMEM81 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM81 Gene

ENSEMBL:
Gene Tree for TMEM81 (if available)
TreeFam:
Gene Tree for TMEM81 (if available)

Paralogs for TMEM81 Gene

No data available for Paralogs for TMEM81 Gene

Variants for TMEM81 Gene

Sequence variations from dbSNP and Humsavar for TMEM81 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1001301775 -- 205,085,771(-) T/C upstream_transcript_variant
rs1001691998 -- 205,086,051(-) A/G upstream_transcript_variant
rs1002992800 -- 205,082,739(-) G/T downstream_transcript_variant
rs1003243198 -- 205,083,014(-) GACAATTG/G downstream_transcript_variant
rs1006434463 -- 205,085,369(-) A/C upstream_transcript_variant

Variation tolerance for TMEM81 Gene

Residual Variation Intolerance Score: 82% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.16; 75.81% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM81 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM81

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TMEM81 Gene

Disorders for TMEM81 Gene

Additional Disease Information for TMEM81

No disorders were found for TMEM81 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM81 Gene

Publications for TMEM81 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for TMEM81 Gene

Sources for TMEM81 Gene

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