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Aliases for TMEM81 Gene

Aliases for TMEM81 Gene

  • Transmembrane Protein 81 2 3 5
  • KVLA2788 3
  • UNQ2788 3
  • HC3107 3

External Ids for TMEM81 Gene

Previous GeneCards Identifiers for TMEM81 Gene

  • GC01M203318
  • GC01M176217

Summaries for TMEM81 Gene

GeneCards Summary for TMEM81 Gene

TMEM81 (Transmembrane Protein 81) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM81 Gene

Genomics for TMEM81 Gene

Regulatory Elements for TMEM81 Gene

Genomic Location for TMEM81 Gene

205,083,129 bp from pter
205,084,460 bp from pter
1,332 bases
Minus strand

Genomic View for TMEM81 Gene

Genes around TMEM81 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM81 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM81 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM81 Gene

Proteins for TMEM81 Gene

  • Protein details for TMEM81 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 81
    Protein Accession:
    Secondary Accessions:
    • Q6UVZ4

    Protein attributes for TMEM81 Gene

    255 amino acids
    Molecular mass:
    28468 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM81 Gene

Proteomics data for TMEM81 Gene at MOPED

Post-translational modifications for TMEM81 Gene

  • Glycosylation at Asn 45
  • Modification sites at PhosphoSitePlus

Other Protein References for TMEM81 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM81 Gene

Domains & Families for TMEM81 Gene

Gene Families for TMEM81 Gene

Protein Domains for TMEM81 Gene


Suggested Antigen Peptide Sequences for TMEM81 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 Ig-like (immunoglobulin-like) domain.
  • Contains 1 Ig-like (immunoglobulin-like) domain.
genes like me logo Genes that share domains with TMEM81: view

Function for TMEM81 Gene

genes like me logo Genes that share phenotypes with TMEM81: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TMEM81

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM81 Gene

Localization for TMEM81 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM81 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for TMEM81 Gene COMPARTMENTS Subcellular localization image for TMEM81 gene
Compartment Confidence
plasma membrane 3
extracellular 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for TMEM81 Gene

Pathways & Interactions for TMEM81 Gene

SuperPathways for TMEM81 Gene

No Data Available

Interacting Proteins for TMEM81 Gene

Gene Ontology (GO) - Biological Process for TMEM81 Gene


No data available for Pathways by source and SIGNOR curated interactions for TMEM81 Gene

Drugs & Compounds for TMEM81 Gene

No Compound Related Data Available

Transcripts for TMEM81 Gene

mRNA/cDNA for TMEM81 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(20) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMEM81 Gene

Transmembrane protein 81:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM81 Gene

No ASD Table

Relevant External Links for TMEM81 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM81 Gene

mRNA expression in normal human tissues for TMEM81 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM81 Gene

SOURCE GeneReport for Unigene cluster for TMEM81 Gene Hs.146928

genes like me logo Genes that share expression patterns with TMEM81: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TMEM81 Gene

Orthologs for TMEM81 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM81 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMEM81 35
  • 98.95 (n)
  • 98.82 (a)
TMEM81 36
  • 99 (a)
(Bos Taurus)
Mammalia TMEM81 36
  • 75 (a)
TMEM81 35
  • 84.95 (n)
  • 82.66 (a)
(Canis familiaris)
Mammalia TMEM81 35
  • 80.82 (n)
  • 75.51 (a)
TMEM81 36
  • 66 (a)
(Mus musculus)
Mammalia Tmem81 16
Tmem81 36
  • 71 (a)
Tmem81 35
  • 77.38 (n)
  • 73.49 (a)
(Monodelphis domestica)
Mammalia TMEM81 36
  • 61 (a)
(Ornithorhynchus anatinus)
Mammalia TMEM81 36
  • 59 (a)
(Rattus norvegicus)
Mammalia Tmem81 35
  • 77.38 (n)
  • 73.81 (a)
(Gallus gallus)
Aves TMEM81 35
  • 55.56 (n)
  • 44.05 (a)
TMEM81 36
  • 41 (a)
(Anolis carolinensis)
Reptilia TMEM81 36
  • 42 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101730568 35
  • 44.93 (n)
  • 30.84 (a)
(Danio rerio)
Actinopterygii TMEM81 36
  • 27 (a)
Species with no ortholog for TMEM81:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM81 Gene

Gene Tree for TMEM81 (if available)
Gene Tree for TMEM81 (if available)

Paralogs for TMEM81 Gene

No data available for Paralogs for TMEM81 Gene

Variants for TMEM81 Gene

Sequence variations from dbSNP and Humsavar for TMEM81 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs4951168 - 205,084,091(+) AGCGC(C/T)GAGTC reference, missense
rs16855059 - 205,084,022(+) GCTCA(A/G)ATTCC reference, missense
rs6676915 -- 205,082,782(+) GCTAA(A/G)AGGAC downstream-variant-500B
rs4950979 -- 205,083,811(+) TTGAC(A/G)AGTCT reference, synonymous-codon
rs6664397 -- 205,082,743(+) TGACC(C/T)TCCCA downstream-variant-500B

Variation tolerance for TMEM81 Gene

Residual Variation Intolerance Score: 82% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.16; 75.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM81 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TMEM81 Gene

Disorders for TMEM81 Gene

Relevant External Links for TMEM81

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TMEM81 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM81 Gene

Publications for TMEM81 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for TMEM81 Gene

Sources for TMEM81 Gene

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