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Aliases for TMEM81 Gene

Aliases for TMEM81 Gene

  • Transmembrane Protein 81 2 3 5
  • KVLA2788 3
  • UNQ2788 3
  • HC3107 3

External Ids for TMEM81 Gene

Previous GeneCards Identifiers for TMEM81 Gene

  • GC01M203318
  • GC01M176217

Summaries for TMEM81 Gene

GeneCards Summary for TMEM81 Gene

TMEM81 (Transmembrane Protein 81) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM81 Gene

Genomics for TMEM81 Gene

Regulatory Elements for TMEM81 Gene

Enhancers for TMEM81 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F205137 0.7 Ensembl ENCODE 10.7 -53.9 -53855 1.0 SCRT1 NR2F1 SCRT2 CNTN2 DSTYK LOC101929459 TMEM81 TMCC2 ENSG00000236108 GC01M205145 PIR35951
GH01F205246 1.1 FANTOM5 Ensembl ENCODE 10.3 -164.5 -164528 5.1 HDAC1 ATF1 ARNT ZNF121 GLIS2 GATA2 CREM CEBPB ZEB2 SMARCA4 TMCC2 DSTYK CNTN2 CDK18 NUAK2 TMEM81 LOC101929459 NFASC MFSD4A PIR41674
GH01F204997 0.7 Ensembl 9.8 +86.9 86859 0.8 EGR2 CNTN2 TMEM81 NFASC GC01P205019 RPL13AP11
GH01F204684 0.4 FANTOM5 8.6 +400.1 400099 0.3 SCRT1 ZNF121 ZNF341 ZBTB40 EZH2 LRRN2 TMEM81 PLEKHA6 NFASC LOC105371691
GH01F205124 0.3 FANTOM5 8 -40.6 -40640 0.3 PKNOX1 JUND MTA2 ZBTB11 TBX21 SPI1 TMEM81 RBBP5 ENSG00000236108
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around TMEM81 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM81 Gene

Chromosome:
1
Start:
205,083,129 bp from pter
End:
205,084,460 bp from pter
Size:
1,332 bases
Orientation:
Minus strand

Genomic View for TMEM81 Gene

Genes around TMEM81 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM81 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM81 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM81 Gene

Proteins for TMEM81 Gene

  • Protein details for TMEM81 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P7N7-TMM81_HUMAN
    Recommended name:
    Transmembrane protein 81
    Protein Accession:
    Q6P7N7
    Secondary Accessions:
    • Q6UVZ4

    Protein attributes for TMEM81 Gene

    Size:
    255 amino acids
    Molecular mass:
    28468 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM81 Gene

Post-translational modifications for TMEM81 Gene

  • Glycosylation at Asn 45
  • Modification sites at PhosphoSitePlus

Other Protein References for TMEM81 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM81 Gene

Domains & Families for TMEM81 Gene

Gene Families for TMEM81 Gene

Protein Domains for TMEM81 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM81 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6P7N7

UniProtKB/Swiss-Prot:

TMM81_HUMAN :
  • Contains 1 Ig-like (immunoglobulin-like) domain.
Domain:
  • Contains 1 Ig-like (immunoglobulin-like) domain.
genes like me logo Genes that share domains with TMEM81: view

Function for TMEM81 Gene

genes like me logo Genes that share phenotypes with TMEM81: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TMEM81

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM81 Gene

Localization for TMEM81 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM81 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM81 Gene COMPARTMENTS Subcellular localization image for TMEM81 gene
Compartment Confidence
plasma membrane 3
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TMEM81 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM81: view

Pathways & Interactions for TMEM81 Gene

SuperPathways for TMEM81 Gene

No Data Available

Interacting Proteins for TMEM81 Gene

Gene Ontology (GO) - Biological Process for TMEM81 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM81 Gene

Transcripts for TMEM81 Gene

mRNA/cDNA for TMEM81 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(20) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMEM81 Gene

Transmembrane protein 81:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM81 Gene

No ASD Table

Relevant External Links for TMEM81 Gene

GeneLoc Exon Structure for
TMEM81
ECgene alternative splicing isoforms for
TMEM81

Expression for TMEM81 Gene

mRNA expression in normal human tissues for TMEM81 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM81 Gene



NURSA nuclear receptor signaling pathways regulating expression of TMEM81 Gene:

TMEM81

SOURCE GeneReport for Unigene cluster for TMEM81 Gene:

Hs.146928
genes like me logo Genes that share expression patterns with TMEM81: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for TMEM81 Gene

Orthologs for TMEM81 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM81 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM81 34 35
  • 98.95 (n)
cow
(Bos Taurus)
Mammalia TMEM81 34 35
  • 84.95 (n)
dog
(Canis familiaris)
Mammalia TMEM81 34 35
  • 80.82 (n)
mouse
(Mus musculus)
Mammalia Tmem81 34 16 35
  • 77.38 (n)
rat
(Rattus norvegicus)
Mammalia Tmem81 34
  • 77.38 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM81 35
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM81 35
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM81 34 35
  • 55.56 (n)
lizard
(Anolis carolinensis)
Reptilia TMEM81 35
  • 42 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101730568 34
  • 44.93 (n)
zebrafish
(Danio rerio)
Actinopterygii TMEM81 35
  • 27 (a)
OneToOne
Species where no ortholog for TMEM81 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM81 Gene

ENSEMBL:
Gene Tree for TMEM81 (if available)
TreeFam:
Gene Tree for TMEM81 (if available)

Paralogs for TMEM81 Gene

No data available for Paralogs for TMEM81 Gene

Variants for TMEM81 Gene

Sequence variations from dbSNP and Humsavar for TMEM81 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10494858 -- 205,083,595(+) ATCCT(C/T)ACCAA reference, synonymous-codon
rs10626651 -- 205,085,744(+) ATTCA(-/AAA)AAAAA downstream-variant-500B, upstream-variant-2KB
rs10900445 -- 205,082,753(+) AGGAA(C/T)AGAAG downstream-variant-500B
rs111946066 -- 205,083,644(+) AGGCT(A/G)ACGCC reference, missense
rs112153572 -- 205,084,490(+) CAGTC(C/T)TTATA upstream-variant-2KB

Variation tolerance for TMEM81 Gene

Residual Variation Intolerance Score: 82% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.16; 75.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM81 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM81

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TMEM81 Gene

Disorders for TMEM81 Gene

Relevant External Links for TMEM81

Genetic Association Database (GAD)
TMEM81
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM81

No disorders were found for TMEM81 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM81 Gene

Publications for TMEM81 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for TMEM81 Gene

Sources for TMEM81 Gene

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