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TMEM81 Gene

protein-coding   GIFtS: 37
GCID: GC01M205052

Transmembrane Protein 81

  Search for TMEM81
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Transmembrane Protein 811 2
HC31072
KVLA27882
UNQ27882

External Ids:    HGNC: 323491   Entrez Gene: 3887302   Ensembl: ENSG000001745297   UniProtKB: Q6P7N73   

Export aliases for TMEM81 gene to outside databases

Previous GC identifers: GC01M203318 GC01M176217


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TMEM81 Gene:
TMEM81 (transmembrane protein 81) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the TMEM81 gene promoter:
         GATA-3   LUN-1   CUTL1   HNF-1A   AREB6   POU2F1   POU2F1a   HNF-1   ARP-1   LyF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMEM81 promoter sequence
   Search Chromatin IP Primers for TMEM81

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TMEM81


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32.1   Ensembl cytogenetic band:  1q32.1   HGNC cytogenetic band: 1q32.1

TMEM81 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM81 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M205052:  view genomic region     (about GC identifiers)

Start:
205,052,257 bp from pter      End:
205,053,645 bp from pter
Size:
1,389 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TMM81_HUMAN, Q6P7N7 (See protein sequence)
Recommended Name: Transmembrane protein 81 precursor  
Size: 255 amino acids; 28468 Da
Secondary accessions: Q6UVZ4

Explore the universe of human proteins at neXtProt for TMEM81: NX_Q6P7N7

Explore proteomics data for TMEM81 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn45

  • See TMEM81 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_976310.1  
    ENSEMBL proteins: 
     ENSP00000356135  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing

    2 InterPro protein domains:
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry Q6P7N7

    ProtoNet protein and cluster: Q6P7N7

    UniProtKB/Swiss-Prot: TMM81_HUMAN, Q6P7N7
    Similarity: Contains 1 Ig-like (immunoglobulin-like) domain


    TMEM81 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    TMEM81 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI phenotypic allele for Tmem81 (no phenotypes)

    TMEM81 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Tmem81tm1Lex for TMEM81

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    hsa-miR-516a-3p hsa-miR-516b*
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TMM81_HUMAN, Q6P7N7: Membrane; Single-pass type I membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    extracellular1
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    TMEM81 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TMEM81
    Interactions:

        Search GeneGlobe Interaction Network for TMEM81

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TMEM81 (TMM81)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TMEM81 gene: 
    NM_203376.1  

    Unigene Cluster for TMEM81:

    Transmembrane protein 81
    Hs.146928  [show with all ESTs]
    Unigene Representative Sequence: AK303432
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000367167(uc001hbt.3)
    miRNA
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    hsa-miR-516a-3p hsa-miR-516b*
    SwitchGear 3'UTR luciferase reporter plasmidTMEM81 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AK303432.1 AY359081.1 BC061592.1 

    1 DOTS entry:

    DT.435831 

    20 AceView cDNA sequences:

    CK819013 BG236299 BF003028 CA975860 NM_203376 AA622711 BQ023111 BC061592 
    BX099616 BM680061 AI420422 BM126731 AA635809 AY359081 BM127029 BM126420 
    BM126127 BM723897 AI167807 BM683361 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TMEM81 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAGAGGGATG
    TMEM81 Expression
    About this image

    TMEM81 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TMEM81 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.146928
        Custom PCR Arrays for TMEM81
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM81

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TMEM81 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tmem811 , 5 transmembrane protein 811, 5 77.38(n)1
    73.49(a)1
      1 (57.42 cM)5
    746261  NM_029025.31  NP_083301.11 
     1325062305 
    chicken
    (Gallus gallus)
    Aves TMEM811 transmembrane protein 81 55.56(n)
    44.05(a)
      771698  XM_004934928.1  XP_004934985.1 
    lizard
    (Anolis carolinensis)
    Reptilia TMEM816
    transmembrane protein 81
    42(a)
    1 ↔ 1
    4(116339137-116339916)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1017305681 transmembrane protein 81-like 44.93(n)
    30.84(a)
      101730568  XM_004918745.1  XP_004918802.1 
    zebrafish
    (Danio rerio)
    Actinopterygii TMEM816
    transmembrane protein 81
    27(a)
    1 ↔ 1
    8(26422846-26425017) ENSDARG00000042536


    ENSEMBL Gene Tree for TMEM81 (if available)
    TreeFam Gene Tree for TMEM81 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TMEM81 (see all 97)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1400513351,2
    C--205051780(+) GGCCTC/TGGAGT 1 -- int10--------
    rs113246481,2
    C--205051829(+) ATCCT-/CCTTTG 1 -- int10--------
    rs66643971,2
    C,F,A,H--205051871(+) TGACCC/TTCCCA 1 -- int115Minor allele frequency- T:0.27NA NS EA WA CSA 882
    rs109004451,2
    C,F,A,H--205051881(+) AGGAAT/CAGAAG 1 -- int19Minor allele frequency- C:0.30EA NS NA 546
    rs1166825961,2
    F--205051883(+) GAATAG/AAAGCT 1 -- int11Minor allele frequency- A:0.03WA 118
    rs66769151,2
    C,F,H--205051910(+) GCTAAA/GAGGAC 1 -- int14Minor allele frequency- G:0.00NS EA 418
    rs1163189051,2
    C,F--205051976(+) GAAGGA/GTCTAG 1 -- int11Minor allele frequency- G:0.01NA 120
    rs1894377801,2
    --205052041(+) CAGGCA/TATTTG 1 -- int10--------
    rs66772331,2
    C,F,H--205052146(+) AGACAA/CTTGGT 1 -- int18Minor allele frequency- C:0.08NS EA WA NA 780
    rs120464121,2
    H--205052156(+) TTTAAT/CGTCTA 1 -- int14Minor allele frequency- C:0.00NS EA 414

    HapMap Linkage Disequilibrium report for TMEM81 (205052257 - 205053645 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TMEM81: --
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing TMEM81
    DNA2.0 Custom Variant and Variant Library Synthesis for TMEM81

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    TMEM81 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TMEM81

    Export disorders for TMEM81 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TMEM81 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with TMEM81)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (Nature 2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 388730 HGNC: 32349 AceView: LOC388730 Ensembl:ENSG00000174529 euGenes: HUgn388730
    ECgene: TMEM81 H-InvDB: TMEM81

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TMEM81 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TMEM81 gene:
    Search GeneIP for patents involving TMEM81

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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