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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TMEM80 Gene

protein-coding   GIFtS: 39
GCID: GC11P000686

transmembrane protein 80
  Search for TMEM80
in
MalaCards
our new
 Human Malady Compendium 
Biological research products
for TMEM80    

Aliases
for TMEM80 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Transmembrane Protein 801 2
FLJ382161

External Ids:    HGNC: 274531   Entrez Gene: 2832322   Ensembl: ENSG000001770427   UniProtKB: Q96HE83   

Export aliases for TMEM80 gene to outside databases

Previous GC identifer: GC11P000512


Summaries
for TMEM80 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
  --

Genomic Views
for TMEM80 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_009237.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TMEM80 gene promoter:
         NF-1   AML1a   GCNF   MyoD   AP-4   c-Ets-1   SRY   CP2   GCNF-1   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TMEM80 promoter sequence
   Search SABiosciences Chromatin IP Primers for TMEM80

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM80


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.5   Ensembl cytogenetic band:  11p15.5   HGNC cytogenetic band: 11p15.5

TMEM80 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM80 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P000686:  view genomic region     (about GC identifiers)

Start:
 695,616 bp from pter      End:
 705,028 bp from pter
Size:
 9,413 bases      Orientation:
 plus strand

Proteins
for TMEM80 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: TMM80_HUMAN, Q96HE8 (See protein sequence)
Recommended Name: Transmembrane protein 80  
Size: 168 amino acids; 18160 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: A8MQ01 A8MXY8 B7WNU5
Alternative splicing: 3 isoforms:  Q96HE8-1   Q96HE8-2   Q96HE8-3   (Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for TMEM80: NX_Q96HE8

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q96HE8

    • TMEM80 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (4 alternative transcripts): 
    NP_001035928.2  NP_001263182.1  NP_001263203.1  NP_777600.3  

    ENSEMBL proteins: 
     ENSP00000380646   ENSP00000380648   ENSP00000436199  

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    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--


    TMEM80 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for TMEM80 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    TMEM80 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR019184 Uncharacterised_TM-17

    Graphical View of Domain Structure for InterPro Entry Q96HE8

    ProtoNet protein and cluster: Q96HE8


    Function
    for TMEM80 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    miRNA
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    Inhib. RNA
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    OriGene shRNA RFP: TMEM80
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    Clone
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    Pathways & Interactions
    for TMEM80 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMEM80

    Drugs & Compounds
    for TMEM80 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TMEM80
    Search CenterWatch for drugs/clinical trials and news about TMEM80 / TMM80 

    Transcripts
    for TMEM80 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for TMEM80 gene (5 alternative transcripts): 
    NM_001042464.1  NM_001042463.2  NM_001276253.1  NM_001276274.1  NM_174940.3  

    Unigene Cluster for TMEM80:

    Transmembrane protein 80
    Hs.448664  [show with all ESTs]
    Unigene Representative Sequence: AK095535
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000397510 ENST00000397512(uc001lqr.3 uc001lqs.3) ENST00000526170(uc010qwi.1)
    ENST00000492023 ENST00000488769 ENST00000528024

    miRNA
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    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMEM80 (see all 7)
    OriGene shRNA RFP: TMEM80
    OriGene siRNA: TMEM80
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMEM80
    Clone
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM80
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM80

    Additional cDNA sequence: 

    AK095535.1 AK302585.1 BC008671.1 BC038383.1 

    10 DOTS entries:

    DT.91753542  DT.100815144  DT.100815143  DT.97855153  DT.95234654  DT.95274066  DT.91850525  DT.95152963 
    DT.75135891  DT.86777141 

    24/107 AceView cDNA sequences (see all 107):

    AA593594 CB044312 AA852081 BX342652 CK819789 AI961996 AI591140 BQ576209 
    BQ025576 BX365977 BC008671 BM141683 BQ022495 BI759237 CK819788 BU753638 
    BM671775 BM141941 NM_174940 AW438908 BM710359 AK124309 BF038771 BC038383 

    GeneLoc Exon Structure


    Expression
    for TMEM80 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TMEM80 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGCCCCCAGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    TMEM80 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    TrophoblastMural TrophectodermMural Trophectoderm CellsExtraembryonic Tissues
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See TMEM80 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TMEM80

    SOURCE GeneReport for Unigene cluster: Hs.448664
        SABiosciences Custom PCR Arrays for TMEM80
    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM80
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM80

    Orthologs
    for TMEM80 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for TMEM80 gene from 4/14 species (see all 14)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves TMEM801 transmembrane protein 80 61.9(n)
    64.29(a)    		   769979  XM_001233294.2  XP_001233295.1 
    lizard
    (Anolis carolinensis)    		 Reptilia TMEM806
    		 --
    		 61(a)
    		 1 ↔ 1
    		 1(74124796-74126979)
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG81166
    CG117606
    		 --
    		 24(a)
    21(a)
    		 many ↔ many
    many ↔ many
    		 3R(4541956-4547050)
    3R(4544920-4545867)
    worm
    (Caenorhabditis elegans)    		 Secernentea mks-26
    		 --
    		 26(a)
    		 1 → many
    		 II(6218588-6219480)


    ENSEMBL Gene Tree for TMEM80 (if available)
    TreeFam Gene Tree for TMEM80 (if available) 

    Paralogs
    for TMEM80 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TMEM80 gene
    TMEM2162  
    1 SIMAP similar gene for TMEM80 using alignment to 2 protein entries:     TMM80_HUMAN (see all proteins):
    TMEM216

    TMEM80 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for TMEM80
    PGOHUM00000243792


    Genomic Variants
    for TMEM80 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/160 NCBI SNPs in TMEM80 are shown (see all 160)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 11 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs65979901,2
    		C,F,A,H,--697761(-) GCGTTA/CCCGGC 2 -- int128Minor allele frequency- C:0.26NS EA NA WA CSA 2775
    rs1879062561,2
    		--697790(+) GTGCAC/TTTGGC 2 -- int10--------
    rs563946181,2
    		C,F,--697890(+) GCCTGT/CGTGAG 2 -- int16Minor allele frequency- C:0.33NA WA EA 364
    rs1180932821,2
    		F,--697913(+) CTGGCA/CCAGAA 2 -- int11Minor allele frequency- C:0.05EA 120
    rs1153118291,2
    		F,--697970(+) ACCAAC/TGCCAG 2 -- int11Minor allele frequency- T:0.03WA 118
    rs1420504901,2
    		--698050(+) CCTGCC/TGCCCA 2 -- int10--------
    rs71150731,2
    		C,--698126(-) TCCATG/ATGTAG 2 -- int14Minor allele frequency- A:0.08NA WA EA 360
    rs1162766231,2
    		F,--698159(+) GCAACT/CGGCCT 2 -- int11Minor allele frequency- C:0.03WA 118
    rs1500988991,2
    		--698168(+) CTGAGC/TCCTTT 2 -- int10--------
    rs79289431,2
    		C,F,A,--698253(-) CCTTTT/ATGATT 2 -- int1 trp38Minor allele frequency- A:0.29WA NA CSA EA 367

    HapMap Linkage Disequilibrium report for TMEM80 (695616 - 705028 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for TMEM80
         4 CNVs: 3831 29884 4725 29883

    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for TMEM80

    Disorders / Diseases
    for TMEM80 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		   --

    Publications
    for TMEM80 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TMEM80 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with TMEM80)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    2. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    4. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)

    External Searches for TMEM80 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing TMEM80 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 283232 HGNC: 27453 AceView: LOC283232 Ensembl:ENSG00000177042 euGenes: HUgn283232
    ECgene: TMEM80 H-InvDB: TMEM80

    Other Databases showing TMEM80 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing TMEM80 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TMEM80 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for TMEM80 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for TMEM80 gene:
    Search GeneIP for patents involving TMEM80

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for TMEM80 gene

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    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
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