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TMEM80 Gene

protein-coding   GIFtS: 40
GCID: GC11P000686

Transmembrane Protein 80

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Transmembrane Protein 801 2

External Ids:    HGNC: 274531   Entrez Gene: 2832322   Ensembl: ENSG000001770427   UniProtKB: Q96HE83   

Export aliases for TMEM80 gene to outside databases

Previous GC identifer: GC11P000512


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TMEM80 Gene:
TMEM80 (transmembrane protein 80) is a protein-coding gene. An important paralog of this gene is TMEM216.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_009237.19  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TMEM80 gene promoter:
         NF-1   AML1a   GCNF   MyoD   AP-4   c-Ets-1   SRY   CP2   GCNF-1   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMEM80 promoter sequence
   Search Chromatin IP Primers for TMEM80

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TMEM80


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.5   Ensembl cytogenetic band:  11p15.5   HGNC cytogenetic band: 11p15.5

TMEM80 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM80 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P000686:  view genomic region     (about GC identifiers)

Start:
695,428 bp from pter      End:
705,028 bp from pter
Size:
9,601 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TMM80_HUMAN, Q96HE8 (See protein sequence)
Recommended Name: Transmembrane protein 80  
Size: 168 amino acids; 18160 Da
Secondary accessions: A8MQ01 A8MXY8 B7WNU5
Alternative splicing: 3 isoforms:  Q96HE8-1   Q96HE8-2   Q96HE8-3   (Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for TMEM80: NX_Q96HE8

Explore proteomics data for TMEM80 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TMEM80 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001035928.2  NP_001263182.1  NP_001263203.1  NP_777600.3  

    ENSEMBL proteins: 
     ENSP00000380646   ENSP00000380648   ENSP00000436199   ENSP00000475039   ENSP00000476563  

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    Search eBioscience for ELISAs for TMEM80 
    antibodies-online kits for TMEM80 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR019184 Uncharacterised_TM-17

    Graphical View of Domain Structure for InterPro Entry Q96HE8

    ProtoNet protein and cluster: Q96HE8


    Find genes that share domains with TMEM80           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TMEM80
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    Browse Sino Biological Human cDNA Clones
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TMM80_HUMAN, Q96HE8: Membrane; Multi-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    endoplasmic reticulum1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with TMEM80           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TMEM80
    Interactions:

        Search GeneGlobe Interaction Network for TMEM80

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for TMEM80 (ENSP000003806464) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GATA5ENSP000002529974STRING: ENSP00000252997
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TMEM80 (TMM80)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TMEM80 gene (5 alternative transcripts): 
    NM_001042464.1  NM_001042463.2  NM_001276253.1  NM_001276274.1  NM_174940.3  

    Unigene Cluster for TMEM80:

    Transmembrane protein 80
    Hs.448664  [show with all ESTs]
    Unigene Representative Sequence: AK095535
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000397510 ENST00000397512(uc001lqr.3 uc001lqs.3) ENST00000526170(uc010qwi.1)
    ENST00000492023 ENST00000488769 ENST00000528024 ENST00000608174
    miRNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): TMEM80 (NM_001042463)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM80
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TMEM80
      QuantiTect SYBR Green Assays in human, mouse, rat TMEM80
      QuantiFast Probe-based Assays in human, mouse, rat TMEM80

    Additional mRNA sequence: 

    AK095535.1 AK302585.1 BC008671.1 BC038383.1 

    10 DOTS entries:

    DT.91753542  DT.100815144  DT.100815143  DT.95234654  DT.97855153  DT.95274066  DT.91850525  DT.95152963 
    DT.75135891  DT.86777141 

    Selected AceView cDNA sequences (see all 107):

    AI591140 BQ025576 CK819788 BM671775 AA593594 BC038383 BC008671 BX342652 
    AI961996 NM_174940 BQ022495 BU753638 BX365977 AK124309 BM141683 BM141941 
    CB044312 AW438908 AA852081 BM710359 BF038771 BQ576209 BI759237 CK819789 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TMEM80 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCCCCCAGG
    TMEM80 Expression
    About this image


    TMEM80 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Trophoblast (Extraembryonic Tissues)
             Mural Trophectoderm Cells Mural Trophectoderm
    TMEM80 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TMEM80 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.448664
        Custom PCR Arrays for TMEM80
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM80

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TMEM80 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tmem801 , 5 transmembrane protein 801, 5 74.86(n)1
    72.95(a)1
      7 (86.65 cM)5
    714481  NM_001141950.11  NP_001135422.11 
     1413277395 
    chicken
    (Gallus gallus)
    Aves TMEM801 transmembrane protein 80 61.47(n)
    63.83(a)
      769979  XM_001233294.3  XP_001233295.1 
    lizard
    (Anolis carolinensis)
    Reptilia TMEM806
    transmembrane protein 80
    61(a)
    1 ↔ 1
    1(74124796-74126979)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia tmem801 transmembrane protein 80 60.95(n)
    62.14(a)
      100486338  XM_002937488.2  XP_002937534.1 


    ENSEMBL Gene Tree for TMEM80 (if available)
    TreeFam Gene Tree for TMEM80 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TMEM80 gene
    TMEM2162  
    1 SIMAP similar gene for TMEM80 using alignment to 3 protein entries:     TMM80_HUMAN (see all proteins):
    TMEM216

    Find genes that share paralogs with TMEM80           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for TMEM80
    PGOHUM00000243792


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TMEM80 (see all 200)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1853373831,2
    --641099(+) GACCTG/TTTGCC 3 -- int10--------
    rs65979901,2
    C,F,A,H--697761(-) GCGTTA/CCCGGC 4 -- int128Minor allele frequency- C:0.26NS EA NA WA CSA 2775
    rs1879062561,2
    --697790(+) GTGCAC/TTTGGC 4 -- int10--------
    rs563946181,2
    C,F--697890(+) GCCTGT/CGTGAG 4 -- int16Minor allele frequency- C:0.33NA WA EA 364
    rs1180932821,2
    C,F--697913(+) CTGGCA/CCAGAA 4 -- int11Minor allele frequency- C:0.05EA 120
    rs1153118291,2
    F--697970(+) ACCAAC/TGCCAG 4 -- int11Minor allele frequency- T:0.03WA 118
    rs1420504901,2
    C--698050(+) CCTGCC/TGCCCA 4 -- int10--------
    rs71150731,2
    C--698126(-) TCCATG/ATGTAG 4 -- int14Minor allele frequency- A:0.08NA WA EA 360
    rs1162766231,2
    C,F--698159(+) GCAACT/CGGCCT 4 -- int11Minor allele frequency- C:0.03WA 118
    rs1500988991,2
    --698168(+) CTGAGC/TCCTTT 4 -- int10--------

    HapMap Linkage Disequilibrium report for TMEM80 (695428 - 705028 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for TMEM80 (see all 16):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv182e199CNV Deletion23128226
    esv1638671CNV Insertion17803354
    nsv896545CNV Loss21882294
    nsv469923CNV Loss18288195
    nsv896579CNV Loss21882294
    nsv896578CNV Loss21882294
    dgv922n71CNV Loss21882294
    dgv943n71CNV Loss21882294
    dgv944n71CNV Loss21882294
    dgv921n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TMEM80
    DNA2.0 Custom Variant and Variant Library Synthesis for TMEM80

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TMEM80 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with TMEM80)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    2. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (Nature 2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (Genome Res. 1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 283232 HGNC: 27453 AceView: LOC283232 Ensembl:ENSG00000177042 euGenes: HUgn283232
    ECgene: TMEM80 H-InvDB: TMEM80

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TMEM80 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TMEM80 gene:
    Search GeneIP for patents involving TMEM80

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     Block miRNA regulation of human, mouse, rat TMEM80 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing TMEM80
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TMEM80 Predesigned siRNA for gene silencing in human, mouse, rat TMEM80
     QuantiFast Probe-based Assays in human, mouse, rat TMEM80 QuantiTect SYBR Green Assays in human, mouse, rat TMEM80
     Custom PCR Arrays for TMEM80 Search Chromatin IP Primers for TMEM80
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TMEM80  Search GeneGlobe Interaction Network for TMEM80
     Regulatory tfbs in TMEM80 promoter
     GenScript Custom Purified and Recombinant Proteins Services for TMEM80 GenScript cDNA clones with any tag delivered in your preferred vector for TMEM80
     GenScript Custom Assay Services for TMEM80 GenScript Custom overexpressing Cell Line Services for TMEM80
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
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     Search for Antibodies & Assays

     Search Tocris compounds for TMEM80 (TMM80)
     Browse Sino Biological Proteins
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     Browse Sino Biological cDNA Clones
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     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
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     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
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     See all of Abcam's Antibodies, Kits and Proteins for TMEM80
     Custom Antibody / Protein Production Service
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     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for TMEM80
     Gene Synthesis
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     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM80
     SwitchGear 3'UTR luciferase reporter plasmids for TMEM80
     SwitchGear Promoter luciferase reporter plasmids for TMEM80
     Search ThermoFisher Antibodies for TMEM80
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM80
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TMEM80
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TMEM80
     LSBio Antibodies in human, mouse, rat for TMEM80
     Browse compounds at ApexBio
     Search Addgene for plasmids for TMEM80
      Search eBioscience for proteins for TMEM80
      Search eBioscience for elisas for TMEM80
      eBioscience FlowRNA Probe Sets
    Customized transgenic rodents for:
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     antibodies-online antibodies for TMEM80 (12 products)
     antibodies-online kits for TMEM80 (6 products)
     antibodies-online peptides for TMEM80
      Search antibodies-online for proteins for TMEM80
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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