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Aliases for TMEM80 Gene

Aliases for TMEM80 Gene

  • Transmembrane Protein 80 2 3 5

External Ids for TMEM80 Gene

Previous GeneCards Identifiers for TMEM80 Gene

  • GC11P000512

Summaries for TMEM80 Gene

GeneCards Summary for TMEM80 Gene

TMEM80 (Transmembrane Protein 80) is a Protein Coding gene. Diseases associated with TMEM80 include Meckel Syndrome 1 and Joubert Syndrome 1. An important paralog of this gene is TMEM216.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM80 Gene

Genomics for TMEM80 Gene

Regulatory Elements for TMEM80 Gene

Enhancers for TMEM80 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around TMEM80 on UCSC Golden Path with GeneCards custom track

Promoters for TMEM80 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for TMEM80 Gene

695,428 bp from pter
705,028 bp from pter
9,601 bases
Plus strand

Genomic View for TMEM80 Gene

Genes around TMEM80 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM80 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM80 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM80 Gene

Proteins for TMEM80 Gene

  • Protein details for TMEM80 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 80
    Protein Accession:
    Secondary Accessions:
    • A8MQ01
    • A8MXY8
    • B7WNU5

    Protein attributes for TMEM80 Gene

    168 amino acids
    Molecular mass:
    18160 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM80 Gene


neXtProt entry for TMEM80 Gene

Post-translational modifications for TMEM80 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM80 Gene

No data available for DME Specific Peptides for TMEM80 Gene

Domains & Families for TMEM80 Gene

Protein Domains for TMEM80 Gene


Suggested Antigen Peptide Sequences for TMEM80 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM80: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TMEM80 Gene

Function for TMEM80 Gene

genes like me logo Genes that share phenotypes with TMEM80: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMEM80 Gene

Localization for TMEM80 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM80 Gene

Membrane; Multi-pass membrane protein. Cell projection, cilium. Note=Localizes at the transition zone, a region between the basal body and the ciliary axoneme. {ECO:0000250 UniProtKB:Q9D3H0}.

Subcellular locations from

Jensen Localization Image for TMEM80 Gene COMPARTMENTS Subcellular localization image for TMEM80 gene
Compartment Confidence
plasma membrane 3
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for TMEM80 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005929 cilium IEA --
GO:0016021 integral component of membrane IEA --
GO:0035869 ciliary transition zone IEA --
genes like me logo Genes that share ontologies with TMEM80: view

Pathways & Interactions for TMEM80 Gene

SuperPathways for TMEM80 Gene

No Data Available

Interacting Proteins for TMEM80 Gene

Gene Ontology (GO) - Biological Process for TMEM80 Gene


No data available for Pathways by source and SIGNOR curated interactions for TMEM80 Gene

Drugs & Compounds for TMEM80 Gene

No Compound Related Data Available

Transcripts for TMEM80 Gene

Unigene Clusters for TMEM80 Gene

Transmembrane protein 80:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM80 Gene

No ASD Table

Relevant External Links for TMEM80 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM80 Gene

mRNA expression in normal human tissues for TMEM80 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TMEM80 Gene

This gene is overexpressed in Liver, secretome (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM80 Gene

Protein tissue co-expression partners for TMEM80 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TMEM80 Gene:


SOURCE GeneReport for Unigene cluster for TMEM80 Gene:

genes like me logo Genes that share expression patterns with TMEM80: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TMEM80 Gene

Orthologs for TMEM80 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM80 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TMEM80 34
  • 83.22 (n)
  • 81.12 (a)
TMEM80 35
  • 80 (a)
(Canis familiaris)
Mammalia TMEM80 34
  • 78.32 (n)
  • 76.92 (a)
TMEM80 35
  • 75 (a)
(Mus musculus)
Mammalia Tmem80 34
  • 74.86 (n)
  • 72.95 (a)
Tmem80 16
Tmem80 35
  • 73 (a)
(Pan troglodytes)
Mammalia TMEM80 34
  • 98.94 (n)
  • 97.88 (a)
TMEM80 35
  • 66 (a)
(Gallus gallus)
Aves TMEM80 34
  • 61.47 (n)
  • 63.83 (a)
TMEM80 35
  • 60 (a)
(Anolis carolinensis)
Reptilia TMEM80 35
  • 61 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem80 34
  • 60.95 (n)
  • 62.14 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 37 (a)
Species where no ortholog for TMEM80 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TMEM80 Gene

Gene Tree for TMEM80 (if available)
Gene Tree for TMEM80 (if available)

Paralogs for TMEM80 Gene

Paralogs for TMEM80 Gene

(1) SIMAP similar genes for TMEM80 Gene using alignment to 3 proteins: Pseudogenes for TMEM80 Gene

genes like me logo Genes that share paralogs with TMEM80: view

Variants for TMEM80 Gene

Structural Variations from Database of Genomic Variants (DGV) for TMEM80 Gene

Variant ID Type Subtype PubMed ID
dgv182e199 CNV deletion 23128226
esv1638671 CNV insertion 17803354
esv2759794 CNV loss 17122850
esv3625074 CNV loss 21293372
nsv1140464 CNV tandem duplication 24896259
nsv1159791 CNV deletion 26073780
nsv469923 CNV loss 18288195
nsv522733 CNV loss 19592680
nsv552869 CNV loss 21841781
nsv832043 CNV loss 17160897

Relevant External Links for TMEM80 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Variation tolerance for TMEM80 Gene

Disorders for TMEM80 Gene

MalaCards: The human disease database

(2) MalaCards diseases for TMEM80 Gene - From: DISEASES

Disorder Aliases PubMed IDs
meckel syndrome 1
  • meckel syndrome
joubert syndrome 1
  • joubert syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TMEM80

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TMEM80: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TMEM80 Gene

Publications for TMEM80 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 65
  2. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 4 65
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 65
  4. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo M.F. … Soares M.B. (Genome Res. 1996) 3 65

Products for TMEM80 Gene

Sources for TMEM80 Gene

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