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Aliases for TMEM79 Gene

Aliases for TMEM79 Gene

  • Mattrin 2 3 4
  • MATT 3 4 6
  • Transmembrane Protein 79 2 3

External Ids for TMEM79 Gene

Previous GeneCards Identifiers for TMEM79 Gene

  • GC01P154519
  • GC01P127613

Summaries for TMEM79 Gene

GeneCards Summary for TMEM79 Gene

TMEM79 is a Protein Coding gene.

UniProtKB/Swiss-Prot for TMEM79 Gene

  • Contributes to the epidermal integrity and skin barrier function. Plays a role in the lamellar granule (LG) secretory system and in the stratum corneum (SC) epithelial cell formation (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM79 Gene

Genomics for TMEM79 Gene

Regulatory Elements for TMEM79 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TMEM79 Gene

Start:
156,282,913 bp from pter
End:
156,293,185 bp from pter
Size:
10,273 bases
Orientation:
Plus strand

Genomic View for TMEM79 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM79 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM79 Gene

Proteins for TMEM79 Gene

  • Protein details for TMEM79 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BSE2-TMM79_HUMAN
    Recommended name:
    Transmembrane protein 79
    Protein Accession:
    Q9BSE2
    Secondary Accessions:
    • B2RE22
    • D3DVB8

    Protein attributes for TMEM79 Gene

    Size:
    394 amino acids
    Molecular mass:
    43520 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM79 Gene

Proteomics data for TMEM79 Gene at MOPED

Post-translational modifications for TMEM79 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM79 Gene

No data available for DME Specific Peptides for TMEM79 Gene

Domains for TMEM79 Gene

Protein Domains for TMEM79 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for TMEM79 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM79: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TMEM79 Gene

Function for TMEM79 Gene

Molecular function for TMEM79 Gene

UniProtKB/Swiss-Prot Function: Contributes to the epidermal integrity and skin barrier function. Plays a role in the lamellar granule (LG) secretory system and in the stratum corneum (SC) epithelial cell formation (By similarity).

Gene Ontology (GO) - Molecular Function for TMEM79 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TMEM79: view

Phenotypes for TMEM79 Gene

genes like me logo Genes that share phenotypes with TMEM79: view

Animal Model Products

CRISPR Products

miRNA for TMEM79 Gene

miRTarBase miRNAs that target TMEM79

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TMEM79 Gene

Localization for TMEM79 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM79 Gene

Lysosome. Golgi apparatus, trans-Golgi network. Membrane; Multi-pass membrane protein. Note=Colocalized with TGOLN2 in the trans-Golgi network. Colocalized with LAMP1 in the lysosome (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM79 Gene COMPARTMENTS Subcellular localization image for TMEM79 gene
Compartment Confidence
plasma membrane 3
cytosol 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TMEM79 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0005765 lysosomal membrane ISS --
GO:0016021 integral component of membrane IEA --
GO:0032588 trans-Golgi network membrane ISS --
genes like me logo Genes that share ontologies with TMEM79: view

Pathways for TMEM79 Gene

SuperPathways for TMEM79 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMEM79 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002070 epithelial cell maturation ISS --
GO:0031069 hair follicle morphogenesis IEA --
GO:0042335 cuticle development IEA --
GO:0045055 regulated secretory pathway ISS --
GO:0045684 positive regulation of epidermis development ISS --
genes like me logo Genes that share ontologies with TMEM79: view

No data available for Pathways by source for TMEM79 Gene

Transcripts for TMEM79 Gene

Unigene Clusters for TMEM79 Gene

Transmembrane protein 79:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM79

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM79 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c
SP1: - - - -
SP2: - - -
SP3: - - - - -
SP4: - -
SP5:
SP6:

Relevant External Links for TMEM79 Gene

GeneLoc Exon Structure for
TMEM79
ECgene alternative splicing isoforms for
TMEM79

Expression for TMEM79 Gene

mRNA expression in normal human tissues for TMEM79 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM79 Gene

This gene is overexpressed in Esophagus - Mucosa (12.0), Skin - Sun Exposed (Lower leg) (6.8), Skin - Not Sun Exposed (Suprapubic) (6.8), and Vagina (5.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TMEM79 Gene

SOURCE GeneReport for Unigene cluster for TMEM79 Gene Hs.347408

mRNA Expression by UniProt/SwissProt for TMEM79 Gene

Q9BSE2-TMM79_HUMAN
Tissue specificity: Expressed in the epidermis of the skin. Expressed in epithelial cells of the outermost layer of the stratum granulosum (SG) and hair follicles (at protein level).
genes like me logo Genes that share expressions with TMEM79: view

In Situ Assay Products

Orthologs for TMEM79 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM79 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM79 35
  • 99.41 (n)
  • 99.75 (a)
TMEM79 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM79 35
  • 88.07 (n)
  • 88.32 (a)
TMEM79 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM79 35
  • 83.25 (n)
  • 84.77 (a)
TMEM79 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem79 35
  • 81.67 (n)
  • 83.63 (a)
Tmem79 16
Tmem79 36
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMEM79 36
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM79 36
  • 53 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem79 35
  • 82.01 (n)
  • 82.86 (a)
chicken
(Gallus gallus)
Aves TMEM79 35
  • 65.05 (n)
  • 57.46 (a)
TMEM79 36
  • 45 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM79 36
  • 47 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.16345 35
zebrafish
(Danio rerio)
Actinopterygii tmem79a 36
  • 32 (a)
OneToMany
tmem79b 36
  • 35 (a)
OneToMany
Species with no ortholog for TMEM79:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM79 Gene

ENSEMBL:
Gene Tree for TMEM79 (if available)
TreeFam:
Gene Tree for TMEM79 (if available)

Paralogs for TMEM79 Gene

No data available for Paralogs for TMEM79 Gene

Variants for TMEM79 Gene

Sequence variations from dbSNP and Humsavar for TMEM79 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs3795728 -- 156,291,700(+) GGACC(C/G)CGGTG utr-variant-3-prime, nc-transcript-variant
rs4661038 -- 156,288,712(+) AAATT(A/T)GTCTT intron-variant
rs4997909 -- 156,290,853(+) TAATT(A/T)AAAAA intron-variant
rs7532219 -- 156,291,362(+) TAGCC(A/T)GACCC intron-variant
rs7537271 -- 156,290,761(+) gaggc(A/G)gaggt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM79 Gene

Variant ID Type Subtype PubMed ID
nsv509524 CNV Insertion 20534489

Relevant External Links for TMEM79 Gene

HapMap Linkage Disequilibrium report
TMEM79
Human Gene Mutation Database (HGMD)
TMEM79

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM79 Gene

Disorders for TMEM79 Gene

UniProtKB/Swiss-Prot

TMM79_HUMAN
  • Note=Defects in TMEM79 may be associated with susceptibility to atopic dermatitis. Atopic dermatitis is a complex, inflammatory disease with multiple alleles at several loci thought to be involved in the pathogenesis. It commonly begins in infancy or early childhood and is characterized by a chronic relapsing form of skin inflammation, a disturbance of epidermal barrier function that culminates in dry skin, and IgE-mediated sensitization to food and environmental allergens. It is manifested by lichenification, excoriation, and crusting, mainly on the flexural surfaces of the elbow and knee.

Relevant External Links for TMEM79

Genetic Association Database (GAD)
TMEM79
genes like me logo Genes that share disorders with TMEM79: view

Publications for TMEM79 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  4. Genome-wide association study of hematological and biochemical traits in a Japanese population. (PMID: 20139978) Kamatani Y. … Kamatani N. (Nat. Genet. 2010) 3 48
  5. Tmem79/Matt is the matted mouse gene and is a predisposing gene for atopic dermatitis in human subjects. (PMID: 24084074) Saunders S.P. … Fallon P.G. (J. Allergy Clin. Immunol. 2013) 3 4

Products for TMEM79 Gene

  • antibodies-online peptides for TMEM79
  • antibodies-online antibodies for TMEM79
  • antibodies-online kits for TMEM79

Sources for TMEM79 Gene

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