Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TMEM74B Gene

Aliases for TMEM74B Gene

  • Transmembrane Protein 74B 2 3 5
  • C20orf46 3 4
  • Chromosome 20 Open Reading Frame 46 2
  • Transmembrane Protein C20orf46 3

External Ids for TMEM74B Gene

Previous HGNC Symbols for TMEM74B Gene

  • C20orf46

Summaries for TMEM74B Gene

GeneCards Summary for TMEM74B Gene

TMEM74B (Transmembrane Protein 74B) is a Protein Coding gene. An important paralog of this gene is TMEM74.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM74B Gene

Genomics for TMEM74B Gene

Regulatory Elements for TMEM74B Gene

Enhancers for TMEM74B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20G001185 1.3 Ensembl ENCODE 6.5 +1.0 978 3.2 HDGF ARNT ARID4B YBX1 DMAP1 YY1 SLC30A9 CBX5 ZNF207 ZNF143 TBC1D20 ACTG1P3 TMEM74B ENSG00000274269
GH20G001242 0.7 ENCODE 10.5 -54.4 -54400 0.6 BCOR SMARCA5 PKNOX1 ZNF146 JUN ZMYM3 FOSL1 ARID1B JUND GATA2 TMEM74B RAD21L1 SNPH
GH20G001108 0.7 ENCODE 10.4 +79.5 79516 0.2 CTCF HBP1 ZNF48 ZBTB40 RAD21 KAT2B ZKSCAN1 ZBTB48 ZNF143 SMC3 C20orf202 RSPO4 TMEM74B PSMF1 GC20P001101
GH20G001102 0.4 FANTOM5 11 +85.5 85469 0.1 TRIM28 TMEM74B RSPO4 ANGPT4 SCRT2 GC20P001101 PSMF1
GH20G001278 0.6 FANTOM5 dbSUPER 3.3 -90.4 -90440 0.1 PRDM10 RAD21L1 SDCBP2 FKBP1A TMEM74B C20orf202 PIR62557 ENSG00000280162
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM74B on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM74B Gene

Chromosome:
20
Start:
1,180,561 bp from pter
End:
1,188,128 bp from pter
Size:
7,568 bases
Orientation:
Minus strand

Genomic View for TMEM74B Gene

Genes around TMEM74B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM74B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM74B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM74B Gene

Proteins for TMEM74B Gene

  • Protein details for TMEM74B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NUR3-TM74B_HUMAN
    Recommended name:
    Transmembrane protein 74B
    Protein Accession:
    Q9NUR3
    Secondary Accessions:
    • D3DVW5

    Protein attributes for TMEM74B Gene

    Size:
    256 amino acids
    Molecular mass:
    27551 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM74B Gene

Post-translational modifications for TMEM74B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TMEM74B Gene

Domains & Families for TMEM74B Gene

Protein Domains for TMEM74B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM74B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NUR3

UniProtKB/Swiss-Prot:

TM74B_HUMAN :
  • Belongs to the TMEM74 family.
Family:
  • Belongs to the TMEM74 family.
genes like me logo Genes that share domains with TMEM74B: view

No data available for Gene Families for TMEM74B Gene

Function for TMEM74B Gene

genes like me logo Genes that share phenotypes with TMEM74B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM74B Gene

Localization for TMEM74B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM74B Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM74B gene
Compartment Confidence
plasma membrane 3
peroxisome 2

Gene Ontology (GO) - Cellular Components for TMEM74B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM74B: view

Pathways & Interactions for TMEM74B Gene

SuperPathways for TMEM74B Gene

No Data Available

Interacting Proteins for TMEM74B Gene

Selected Interacting proteins: Q9NUR3-TM74B_HUMAN for TMEM74B Gene via IID

Gene Ontology (GO) - Biological Process for TMEM74B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM74B Gene

Drugs & Compounds for TMEM74B Gene

No Compound Related Data Available

Transcripts for TMEM74B Gene

Unigene Clusters for TMEM74B Gene

Transmembrane protein 74B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM74B Gene

ExUns: 1a · 1b ^ 2 ^ 3
SP1:
SP2:

Relevant External Links for TMEM74B Gene

GeneLoc Exon Structure for
TMEM74B
ECgene alternative splicing isoforms for
TMEM74B

Expression for TMEM74B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM74B Gene

mRNA differential expression in normal tissues according to GTEx for TMEM74B Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x4.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM74B Gene



NURSA nuclear receptor signaling pathways regulating expression of TMEM74B Gene:

TMEM74B

SOURCE GeneReport for Unigene cluster for TMEM74B Gene:

Hs.516834
genes like me logo Genes that share expression patterns with TMEM74B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM74B Gene

Orthologs for TMEM74B Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM74B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM74B 34 35
  • 99.35 (n)
dog
(Canis familiaris)
Mammalia TMEM74B 34 35
  • 89.02 (n)
cow
(Bos Taurus)
Mammalia TMEM74B 34 35
  • 87.85 (n)
mouse
(Mus musculus)
Mammalia Tmem74b 34 16 35
  • 85.49 (n)
rat
(Rattus norvegicus)
Mammalia Tmem74b 34
  • 85.09 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM74B 35
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM74B 35
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100486112 34
  • 68.52 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC797493 34
  • 62.71 (n)
tmem74b 35
  • 53 (a)
OneToOne
Species where no ortholog for TMEM74B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM74B Gene

ENSEMBL:
Gene Tree for TMEM74B (if available)
TreeFam:
Gene Tree for TMEM74B (if available)

Paralogs for TMEM74B Gene

Paralogs for TMEM74B Gene

(1) SIMAP similar genes for TMEM74B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TMEM74B: view

Variants for TMEM74B Gene

Sequence variations from dbSNP and Humsavar for TMEM74B Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1000172295 -- 1,183,347(+) GAGCA(A/G)ATGAA intron-variant
rs1000284108 -- 1,188,939(+) AGGTG(A/C)ACATA intron-variant, upstream-variant-2KB
rs1000466601 -- 1,188,550(+) CACAC(A/G)TACCA intron-variant, upstream-variant-2KB
rs1000718899 -- 1,184,967(+) AGACG(C/T)GGGAC intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000722824 -- 1,186,369(+) GAAGT(A/G)CCTAG intron-variant, nc-transcript-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TMEM74B Gene

Variant ID Type Subtype PubMed ID
esv3893267 CNV loss 25118596
nsv1057097 CNV gain 25217958
nsv3251 CNV insertion 18451855
nsv952968 CNV deletion 24416366

Variation tolerance for TMEM74B Gene

Residual Variation Intolerance Score: 55.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.98; 20.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM74B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM74B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM74B Gene

Disorders for TMEM74B Gene

Relevant External Links for TMEM74B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM74B

No disorders were found for TMEM74B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM74B Gene

Publications for TMEM74B Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4 64
  3. Replication of top markers of a genome-wide association study in multiple sclerosis in Spain. (PMID: 20944657) Cavanillas M.L. … Urcelay E. (Genes Immun. 2011) 3 64
  4. Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening. (PMID: 17474147) Wu C. … Li S.S. (Proteomics 2007) 3 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for TMEM74B Gene

Sources for TMEM74B Gene

Content
Loading form....