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TMEM74B Gene

protein-coding   GIFtS: 40
GCID: GC20M001161

Transmembrane Protein 74B

(Previous name: chromosome 20 open reading frame 46)
(Previous symbol: C20orf46)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Transmembrane Protein 74B1 2
C20orf461 2 3
Chromosome 20 Open Reading Frame 461
Transmembrane Protein C20orf462

External Ids:    HGNC: 158931   Entrez Gene: 553212   Ensembl: ENSG000001258957   UniProtKB: Q9NUR33   
ORGUL members:         

Export aliases for TMEM74B gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TMEM74B Gene:
TMEM74B (transmembrane protein 74B) is a protein-coding gene. An important paralog of this gene is TMEM74.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000020.10  NT_011387.9  NC_018931.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for TMEM74B
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TMEM74B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p13   Ensembl cytogenetic band:  20p13   HGNC cytogenetic band: 20p13

TMEM74B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM74B gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M001161:  view genomic region     (about GC identifiers)

Start:
1,161,205 bp from pter      End:
1,166,059 bp from pter
Size:
4,855 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TM74B_HUMAN, Q9NUR3 (See protein sequence)
Recommended Name: Transmembrane protein 74B  
Size: 256 amino acids; 27551 Da
Secondary accessions: D3DVW5

Explore the universe of human proteins at neXtProt for TMEM74B: NX_Q9NUR3

Explore proteomics data for TMEM74B at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TMEM74B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060824.1  
    ENSEMBL proteins: 
     ENSP00000371318   ENSP00000400552  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: Q9NUR3

    UniProtKB/Swiss-Prot: TM74B_HUMAN, Q9NUR3
    Similarity: Belongs to the TMEM74 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for TMEM74B

    miRNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TM74B_HUMAN, Q9NUR3: Membrane; Multi-pass membrane protein (Potential)

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with TMEM74B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TMEM74B
    Interactions:

        Search GeneGlobe Interaction Network for TMEM74B

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for TMEM74B (Q9NUR33 ENSP000003713184) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ABL1P005193, ENSP000003614234I2D: score=1 STRING: ENSP00000361423
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TMEM74B (TM74B)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TMEM74B gene: 
    NM_018354.1  

    Unigene Cluster for TMEM74B:

    Transmembrane protein 74B
    Hs.516834  [show with all ESTs]
    Unigene Representative Sequence: AK126837
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000381894(uc010gaa.1 uc002weq.1) ENST00000429036 ENST00000481747

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    Additional mRNA sequence: 

    AK002052.1 AK126837.1 BC126988.1 BC126989.1 

    5 DOTS entries:

    DT.431317  DT.100018041  DT.95153522  DT.97765873  DT.95155571 

    Selected AceView cDNA sequences (see all 43):

    BM998032 BM665389 BM699884 BQ013529 CF529250 NM_018354 CA443597 BM545116 
    CF530022 CA407847 BU734023 AK002052 BU737622 AU157393 AA861530 BG496625 
    CA439662 AW628999 CB528626 AK126837 CD367044 AI991260 AI266152 BV197497 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for TMEM74B    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3
    SP1:                        
    SP2:                        


    ECgene alternative splicing isoforms for TMEM74B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TMEM74B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCCACACGG
    TMEM74B Expression
    About this image

    TMEM74B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TMEM74B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.516834
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM74B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TMEM74B gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tmem74b1 , 5 RIKEN cDNA 5430405G05 gene5
    transmembrane protein 74B1
    85.49(n)1
    90.09(a)1
      2 (74.83 cM)5
    1088321  NM_001160363.11  NP_001153835.11 
     1517020085 
    lizard
    (Anolis carolinensis)
    Reptilia TMEM74B6
    transmembrane protein 74B
    59(a)
    1 ↔ 1
    GL343346.1(692324-693034)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004861121 transmembrane protein 74B-like 68.52(n)
    67.36(a)
      100486112  XM_004920973.1  XP_004921030.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC7974931 transmembrane protein 74B-like 62.71(n)
    64.36(a)
      797493  XM_001337915.3  XP_001337951.1 


    ENSEMBL Gene Tree for TMEM74B (if available)
    TreeFam Gene Tree for TMEM74B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TMEM74B gene
    TMEM742  
    1 SIMAP similar gene for TMEM74B using alignment to 2 protein entries:     TM74B_HUMAN (see all proteins):
    TMEM74

    Find genes that share paralogs with TMEM74B           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TMEM74B (see all 173)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs563511121,2
    C,F--1160920(+) CCAACC/TCCCTC 1 -- ds50012Minor allele frequency- T:0.09WA 120
    rs573829001,2
    C--1161036(+) CACCT-/CCCCCAC 1 -- ds50010--------
    rs570174941,2
    F--1161050(+) TAGATG/TATCAG 1 -- ds50011Minor allele frequency- T:0.08WA 118
    rs60780541,2
    C,F,H--1161063(+) CTGAAA/GGGGAC 1 -- ds500112Minor allele frequency- G:0.11NS EA NA WA 1068
    rs60403491,2
    C,F,A,H--1161113(+) GACAGC/AAGAGG 1 -- ds500123Minor allele frequency- A:0.45NS EA NA WA CSA 1564
    rs1911344221,2
    --1161216(+) AGCAGC/TGGTTT 1 -- ut310--------
    rs1834392961,2
    --1161217(+) GCAGCA/GGTTTC 1 -- ut310--------
    rs1405472941,2
    C,F--1161558(+) GCCTGG/ACCCCC 2 /G syn11Minor allele frequency- A:0.01NA 4550
    rs2007020791,2
    --1161571(+) CCCCAC/TTGAGC 2 N S mis10--------
    rs1866426781,2
    --1161589(+) TGCGCA/GGGTTA 2 P L mis10--------

    HapMap Linkage Disequilibrium report for TMEM74B (1161205 - 1166059 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TMEM74B: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TMEM74B
    DNA2.0 Custom Variant and Variant Library Synthesis for TMEM74B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TMEM74B gene integrated from 10 sources:
    (articles sorted by number of sources associating them with TMEM74B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    2. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
    3. Replication of top markers of a genome-wide association study in multiple sclerosis in Spain. (PubMed id 20944657)1 Cavanillas M.L....Urcelay E. (Genes Immun. 2011)
    4. Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening. (PubMed id 17474147)1 Wu C....Li S.S. (Proteomics 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55321 HGNC: 15893 AceView: C20orf46 Ensembl:ENSG00000125895 euGenes: HUgn55321
    ECgene: TMEM74B H-InvDB: TMEM74B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TMEM74B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TMEM74B gene:
    Search GeneIP for patents involving TMEM74B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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     Browse ESI BIO Cell Lines and PureStem Progenitors for TMEM74B
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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