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Aliases for TMEM74 Gene

Aliases for TMEM74 Gene

  • Transmembrane Protein 74 2 3 5
  • NET36 3

External Ids for TMEM74 Gene

Previous GeneCards Identifiers for TMEM74 Gene

  • GC08M109865
  • GC08M105116
  • GC08M109619

Summaries for TMEM74 Gene

GeneCards Summary for TMEM74 Gene

TMEM74 (Transmembrane Protein 74) is a Protein Coding gene. Diseases associated with TMEM74 include Fuchs' Endothelial Dystrophy. An important paralog of this gene is TMEM74B.

UniProtKB/Swiss-Prot for TMEM74 Gene

  • Plays an essential role in autophagy. TMEM74-induced autophagy may involve PI3K signal transduction.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM74 Gene

Genomics for TMEM74 Gene

Regulatory Elements for TMEM74 Gene

Enhancers for TMEM74 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TMEM74 on UCSC Golden Path with GeneCards custom track

Promoters for TMEM74 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TMEM74 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM74 Gene

Chromosome:
8
Start:
108,606,850 bp from pter
End:
108,787,615 bp from pter
Size:
180,766 bases
Orientation:
Minus strand

Genomic View for TMEM74 Gene

Genes around TMEM74 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM74 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM74 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM74 Gene

Proteins for TMEM74 Gene

  • Protein details for TMEM74 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96NL1-TMM74_HUMAN
    Recommended name:
    Transmembrane protein 74
    Protein Accession:
    Q96NL1

    Protein attributes for TMEM74 Gene

    Size:
    305 amino acids
    Molecular mass:
    33338 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM74 Gene

Proteomics data for TMEM74 Gene at MOPED

Post-translational modifications for TMEM74 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM74 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM74 Gene

Domains & Families for TMEM74 Gene

Protein Domains for TMEM74 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for TMEM74 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96NL1

UniProtKB/Swiss-Prot:

TMM74_HUMAN :
  • Belongs to the TMEM74 family.
Family:
  • Belongs to the TMEM74 family.
genes like me logo Genes that share domains with TMEM74: view

No data available for Gene Families for TMEM74 Gene

Function for TMEM74 Gene

Molecular function for TMEM74 Gene

UniProtKB/Swiss-Prot Function:
Plays an essential role in autophagy. TMEM74-induced autophagy may involve PI3K signal transduction.
genes like me logo Genes that share phenotypes with TMEM74: view

Animal Model Products

miRNA for TMEM74 Gene

miRTarBase miRNAs that target TMEM74

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM74 Gene

Localization for TMEM74 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM74 Gene

Lysosome membrane; Multi-pass membrane protein. Cytoplasmic vesicle, autophagosome membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM74 Gene COMPARTMENTS Subcellular localization image for TMEM74 gene
Compartment Confidence
vacuole 4
lysosome 3
plasma membrane 3
cytosol 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TMEM74 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005765 lysosomal membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM74: view

Pathways & Interactions for TMEM74 Gene

SuperPathways for TMEM74 Gene

No Data Available

Interacting Proteins for TMEM74 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000297459%0d%0a9606.ENSP00000359375%0d%0a
Selected Interacting proteins: ENSP00000297459 Q96NL1-TMM74_HUMAN for TMEM74 Gene via STRING UniProtKB

Gene Ontology (GO) - Biological Process for TMEM74 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM74 Gene

Drugs & Compounds for TMEM74 Gene

No Compound Related Data Available

Transcripts for TMEM74 Gene

mRNA/cDNA for TMEM74 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMEM74 Gene

Transmembrane protein 74:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM74 Gene

No ASD Table

Relevant External Links for TMEM74 Gene

GeneLoc Exon Structure for
TMEM74
ECgene alternative splicing isoforms for
TMEM74

Expression for TMEM74 Gene

mRNA expression in normal human tissues for TMEM74 Gene

Protein differential expression in normal tissues from HIPED for TMEM74 Gene

This gene is overexpressed in Adipocyte (65.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TMEM74 Gene



SOURCE GeneReport for Unigene cluster for TMEM74 Gene Hs.99439

mRNA Expression by UniProt/SwissProt for TMEM74 Gene

Q96NL1-TMM74_HUMAN
Tissue specificity: Expressed in heart, lung, and placenta.
genes like me logo Genes that share expression patterns with TMEM74: view

Protein tissue co-expression partners for TMEM74 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for TMEM74 Gene

Orthologs for TMEM74 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM74 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TMEM74 35
  • 85.79 (n)
  • 86.23 (a)
TMEM74 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM74 35
  • 86.01 (n)
  • 84.92 (a)
TMEM74 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem74 35
  • 81.42 (n)
  • 77.05 (a)
Tmem74 16
Tmem74 36
  • 77 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TMEM74 35
  • 99.56 (n)
  • 100 (a)
TMEM74 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem74 35
  • 80.55 (n)
  • 77.05 (a)
oppossum
(Monodelphis domestica)
Mammalia TMEM74 36
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM74 36
  • 45 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC100858101 35
  • 63.73 (n)
  • 63.05 (a)
TMEM74 36
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM74 36
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.5572 35
tmem74 35
  • 52.89 (n)
  • 48.34 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100331423 35
  • 56.28 (n)
  • 54.23 (a)
CABZ01021538.1 36
  • 40 (a)
OneToMany
TMEM74 (2 of 2) 36
  • 46 (a)
OneToMany
Species with no ortholog for TMEM74:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM74 Gene

ENSEMBL:
Gene Tree for TMEM74 (if available)
TreeFam:
Gene Tree for TMEM74 (if available)

Paralogs for TMEM74 Gene

Paralogs for TMEM74 Gene

(1) SIMAP similar genes for TMEM74 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TMEM74: view

Variants for TMEM74 Gene

Sequence variations from dbSNP and Humsavar for TMEM74 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs11323077 -- 108,788,961(+) GTCTC(-/A)AAAAA upstream-variant-2KB
rs11995154 -- 108,788,287(+) taaaa(A/G)aaaat upstream-variant-2KB
rs11995185 -- 108,788,312(+) AAGGC(A/G)AAACT upstream-variant-2KB
rs57960607 -- 108,787,366(+) TAGTA(C/T)TCGGA intron-variant
rs58115511 -- 108,788,376(+) GTGGG(-/GG/T/TC/TG)GGGGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TMEM74 Gene

Variant ID Type Subtype PubMed ID
nsv831420 CNV Gain 17160897
nsv891269 CNV Gain 21882294

Variation tolerance for TMEM74 Gene

Residual Variation Intolerance Score: 43.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.31; 26.11% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TMEM74 Gene

Disorders for TMEM74 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TMEM74 Gene - From: DISEASES

Disorder Aliases PubMed IDs
fuchs' endothelial dystrophy
  • fced
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TMEM74

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM74
genes like me logo Genes that share disorders with TMEM74: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TMEM74 Gene

Publications for TMEM74 Gene

  1. TMEM74, a lysosome and autophagosome protein, regulates autophagy. (PMID: 18294959) Yu C. … Wang L. (Biochem. Biophys. Res. Commun. 2008) 3 4 23 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for TMEM74 Gene

Sources for TMEM74 Gene

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