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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TMEM74 Gene

protein-coding   GIFtS: 41
GCID: GC08M109619

transmembrane protein 74
  Search for TMEM74
in
MalaCards
our new
 Human Malady Compendium 
Biological research products
for TMEM74    

Aliases
for TMEM74 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Transmembrane Protein 741 2
NET361 2
FLJ306681

External Ids:    HGNC: 264091   Entrez Gene: 1577532   Ensembl: ENSG000001648417   OMIM: 6139355   UniProtKB: Q96NL13   
ORGUL members:         
NONCODE:n341583    

Export aliases for TMEM74 gene to outside databases

Previous GC identifers: GC08M109865 GC08M105116


Summaries
for TMEM74 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: TMM74_HUMAN, Q96NL1
Function: Plays an essential role in autophagy. TMEM74-induced autophagy may involve PI3K signal transduction




Genomic Views
for TMEM74 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.1  NT_008046.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TMEM74 gene promoter:
         Nkx3-1 v2   Nkx3-1   HFH-3   FOXI1   TBP   Nkx3-1 v4   Brachyury   Nkx3-1 v3   Nkx3-1 v1   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TMEM74 promoter sequence
   Search SABiosciences Chromatin IP Primers for TMEM74

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM74


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q23.1   Ensembl cytogenetic band:  8q23.1   HGNC cytogenetic band: 8q23.1

TMEM74 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM74 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M109619:  view genomic region     (about GC identifiers)

Start:
 109,619,079 bp from pter      End:
 109,799,844 bp from pter
Size:
 180,766 bases      Orientation:
 minus strand

Proteins
for TMEM74 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: TMM74_HUMAN, Q96NL1 (See protein sequence)
Recommended Name: Transmembrane protein 74  
Size: 305 amino acids; 33338 Da
Subcellular location: Lysosome membrane; Multi-pass membrane protein. Cytoplasmic vesicle, autophagosome membrane;
Multi-pass membrane protein

Explore the universe of human proteins at neXtProt for TMEM74: NX_Q96NL1

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q96NL1

    • TMEM74 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_694560.1  
    ENSEMBL proteins: 
     ENSP00000297459  

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    Uscn Proteins for TMEM74

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000421autophagic vacuole membrane IEA--
    GO:0005765lysosomal membrane IEA--
    GO:0016021integral to membrane IEA--
    GO:0031410cytoplasmic vesicle IEA--


    TMEM74 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for TMEM74 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q96NL1

    UniProtKB/Swiss-Prot: TMM74_HUMAN, Q96NL1
    Similarity: Belongs to the TMEM74 family


    Function
    for TMEM74 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: TMM74_HUMAN, Q96NL1
    Function: Plays an essential role in autophagy. TMEM74-induced autophagy may involve PI3K signal transduction

    miRNA
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    hsa-miR-875-3p hsa-miR-520f hsa-miR-3126-3p hsa-miR-589 hsa-miR-580
    SwitchGear 3'UTR luciferase reporter plasmid: TMEM74 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Pathways & Interactions
    for TMEM74 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMEM74

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006914autophagy IEA--


    TMEM74 for ontologies           About GeneDecksing



    Drugs & Compounds
    for TMEM74 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TMEM74
    Search CenterWatch for drugs/clinical trials and news about TMEM74 / TMM74 

    Transcripts
    for TMEM74 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for TMEM74 gene: 
    NM_153015.1  

    Unigene Cluster for TMEM74:

    Transmembrane protein 74
    Hs.99439  [show with all ESTs]
    Unigene Representative Sequence: AK055230
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000518838(uc003ymx.3) ENST00000297459(uc003ymy.1)

    miRNA
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    hsa-miR-875-3p hsa-miR-520f hsa-miR-3126-3p hsa-miR-589 hsa-miR-580
    SwitchGear 3'UTR luciferase reporter plasmid: TMEM74 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMEM74 (see all 4)
    OriGene shRNA RFP: TMEM74
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMEM74
    Clone
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    GenScript: all cDNA clones in your preferred vector: TMEM74 (NM_153015)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMEM74
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM74 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM74
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM74

    Additional cDNA sequence: 

    AK055230.1 BC030710.2 BC033057.2 

    2 DOTS entries:

    DT.40119734  DT.99932855 

    12 AceView cDNA sequences:

    AK055230 AA456293 AI220089 NM_153015 AI816528 BC030710 BI547599 BG703752 
    BC033057 BG700300 BX095717 AA456690 

    GeneLoc Exon Structure


    Expression
    for TMEM74 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TMEM74 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GAATTTTTAG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    TMEM74 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Definitive endoderm-like cells (A scalable, suspensi...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See TMEM74 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TMEM74

    SOURCE GeneReport for Unigene cluster: Hs.99439

    UniProtKB/Swiss-Prot: TMM74_HUMAN, Q96NL1
    Tissue specificity: Expressed in heart, lung, and placenta

        SABiosciences Expression via Pathway-Focused PCR Array including TMEM74: 
              Autophagy in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM74

    Orthologs
    for TMEM74 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for TMEM74 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Tmem741 , 5 transmembrane protein 741, 5 81.42(n)1
    77.05(a)1    		   15 (16.82 cM)5
    2394081  NM_175502.31  NP_780711.11 
     438666955 
    chicken
    (Gallus gallus)    		 Aves LOC1008581011 transmembrane protein 74-like 66.67(n)
    69.49(a)    		   100858101  XM_003640853.1  XP_003640901.1 
    lizard
    (Anolis carolinensis)    		 Reptilia TMEM746
    		 --
    		 78(a)
    		 1 ↔ 1
    		 4(11054005-11054748)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia Str.55722 Transcribed sequence with weak similarity to protein refNP_060824.1 (H.sapiens) hypothetical protein FLJ11190 [Homo sapiens] less 70.11(n)    BQ525417.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC1003314231 transmembrane protein 74-like 55.51(n)
    52.63(a)    		   100331423  XM_002664969.1  XP_002665015.1 


    ENSEMBL Gene Tree for TMEM74 (if available)
    TreeFam Gene Tree for TMEM74 (if available) 

    Paralogs
    for TMEM74 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TMEM74 gene
    TMEM74B2  
    1 SIMAP similar gene for TMEM74 using alignment to 1 protein entry:     TMM74_HUMAN:
    TMEM74B

    TMEM74 for paralogs           About GeneDecksing



    Genomic Variants
    for TMEM74 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/129 NCBI SNPs in TMEM74 are shown (see all 129)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 8 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs126776171,2
    		H--109794853(+) ATTCCA/TCAGTT 1 -- ds50014Minor allele frequency- T:0.00NS EA 418
    rs1854130211,2
    		--109794997(+) TGATCC/GTGGTA 1 -- ds50010--------
    rs1907126151,2
    		--109795064(+) CAGAGC/TTGCAA 1 -- ds50010--------
    rs1467002071,2
    		--109795197(+) CTGCTC/TTTAGA 1 -- ds50010--------
    rs770199931,2
    		--109795235(+) GTTCAC/AAGTTG 1 -- ds50012Minor allele frequency- A:0.10CSA WA 120
    rs1822394171,2
    		--109795290(+) GATGAC/GTACAG 1 -- ds50010--------
    rs2010561661,2
    		--109795336(+) TTTTA-/TTTTTT 1 -- ds50010--------
    rs733135631,2
    		C,--109795383(+) GGGAAG/ATGCTC 1 -- ut312Minor allele frequency- A:0.04WA 120
    rs1852635511,2
    		--109795422(+) CCTGCA/GAGGCA 1 -- ut310--------
    rs1402203131,2
    		--109795485(+) ATAACA/GAGATG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for TMEM74 (109619079 - 109799844 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for TMEM74: --

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for TMEM74 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    TMEM74 for disorders           About MalaCards

    TMEM74 for disorders           About GeneDecksing

    OMIM gene information: 613935    OMIM disorders: --


    Export disorders for TMEM74 gene to outside databases

    Publications
    for TMEM74 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TMEM74 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with TMEM74)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. TMEM74, a lysosome and autophagosome protein, regulates autophagy. (PubMed id 18294959)1, 2, 9 Yu C....Wang L. (2008)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    5. High-throughput functional screening for autophagy-related genes and identification of TM9SF1 as an autophagosome-inducing gene. (PubMed id 19029833)2 He P.... Ma D. (2009)
    6. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)

    External Searches for TMEM74 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing TMEM74 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 157753 HGNC: 26409 AceView: FLJ30668 Ensembl:ENSG00000164841 euGenes: HUgn157753
    ECgene: TMEM74 H-InvDB: TMEM74

    Other Databases showing TMEM74 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing TMEM74 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TMEM74 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for TMEM74 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for TMEM74 gene:
    Search GeneIP for patents involving TMEM74

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for TMEM74 gene

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    About This Section

     
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