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Aliases for TMEM74 Gene

Aliases for TMEM74 Gene

  • Transmembrane Protein 74 2 3
  • NET36 3

External Ids for TMEM74 Gene

Previous GeneCards Identifiers for TMEM74 Gene

  • GC08M109865
  • GC08M105116
  • GC08M109619

Summaries for TMEM74 Gene

GeneCards Summary for TMEM74 Gene

TMEM74 is a Protein Coding gene. An important paralog of this gene is TMEM74B.

UniProtKB/Swiss-Prot for TMEM74 Gene

  • Plays an essential role in autophagy. TMEM74-induced autophagy may involve PI3K signal transduction.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM74 Gene

Genomics for TMEM74 Gene

Regulatory Elements for TMEM74 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TMEM74 Gene

108,606,850 bp from pter
108,787,615 bp from pter
180,766 bases
Minus strand

Genomic View for TMEM74 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM74 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM74 Gene

Proteins for TMEM74 Gene

  • Protein details for TMEM74 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 74
    Protein Accession:
    Secondary Accessions:

    Protein attributes for TMEM74 Gene

    305 amino acids
    Molecular mass:
    33338 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM74 Gene

Proteomics data for TMEM74 Gene at MOPED

Post-translational modifications for TMEM74 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM74 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM74 Gene

Domains for TMEM74 Gene

Protein Domains for TMEM74 Gene


Suggested Antigen Peptide Sequences for TMEM74 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q96NL1
  • Belongs to the TMEM74 family.
genes like me logo Genes that share domains with TMEM74: view

No data available for Gene Families for TMEM74 Gene

Function for TMEM74 Gene

Molecular function for TMEM74 Gene

UniProtKB/Swiss-Prot Function: Plays an essential role in autophagy. TMEM74-induced autophagy may involve PI3K signal transduction.

Gene Ontology (GO) - Molecular Function for TMEM74 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TMEM74: view

Animal Model Products

CRISPR Products

miRNA for TMEM74 Gene

miRTarBase miRNAs that target TMEM74

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TMEM74 Gene

Localization for TMEM74 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM74 Gene

Lysosome membrane; Multi-pass membrane protein. Cytoplasmic vesicle, autophagosome membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for TMEM74 Gene COMPARTMENTS Subcellular localization image for TMEM74 gene
Compartment Confidence
lysosome 5
vacuole 5
plasma membrane 3
cytosol 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TMEM74 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000421 autophagic vacuole membrane IEA --
GO:0005764 lysosome --
GO:0005765 lysosomal membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031410 cytoplasmic vesicle IEA --
genes like me logo Genes that share ontologies with TMEM74: view

Pathways for TMEM74 Gene

SuperPathways for TMEM74 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for TMEM74 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000297459 Q96NL1-TMM74_HUMAN for TMEM74 Gene via STRING UniProtKB

Gene Ontology (GO) - Biological Process for TMEM74 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006914 autophagy IEA --
genes like me logo Genes that share ontologies with TMEM74: view

No data available for Pathways by source for TMEM74 Gene

Transcripts for TMEM74 Gene

mRNA/cDNA for TMEM74 Gene

(12) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMEM74 Gene

Transmembrane protein 74:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM74

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for TMEM74

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM74 Gene

No ASD Table

Relevant External Links for TMEM74 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM74 Gene

mRNA expression in normal human tissues for TMEM74 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TMEM74 Gene

SOURCE GeneReport for Unigene cluster for TMEM74 Gene Hs.99439

mRNA Expression by UniProt/SwissProt for TMEM74 Gene

Tissue specificity: Expressed in heart, lung, and placenta.
genes like me logo Genes that share expressions with TMEM74: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for TMEM74 Gene

Orthologs for TMEM74 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM74 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMEM74 35
  • 99.56 (n)
  • 100 (a)
TMEM74 36
  • 100 (a)
(Bos Taurus)
Mammalia TMEM74 35
  • 85.79 (n)
  • 86.23 (a)
TMEM74 36
  • 86 (a)
(Canis familiaris)
Mammalia TMEM74 35
  • 86.01 (n)
  • 84.92 (a)
TMEM74 36
  • 85 (a)
(Mus musculus)
Mammalia Tmem74 35
  • 81.42 (n)
  • 77.05 (a)
Tmem74 16
Tmem74 36
  • 77 (a)
(Monodelphis domestica)
Mammalia TMEM74 36
  • 66 (a)
(Ornithorhynchus anatinus)
Mammalia TMEM74 36
  • 45 (a)
(Rattus norvegicus)
Mammalia Tmem74 35
  • 80.55 (n)
  • 77.05 (a)
(Gallus gallus)
Aves LOC100858101 35
  • 63.73 (n)
  • 63.05 (a)
TMEM74 36
  • 58 (a)
(Anolis carolinensis)
Reptilia TMEM74 36
  • 77 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.5572 35
tmem74 35
  • 52.89 (n)
  • 48.34 (a)
(Danio rerio)
Actinopterygii CABZ01021538.1 36
  • 40 (a)
LOC100331423 35
  • 56.28 (n)
  • 54.23 (a)
TMEM74 (2 of 2) 36
  • 46 (a)
Species with no ortholog for TMEM74:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM74 Gene

Gene Tree for TMEM74 (if available)
Gene Tree for TMEM74 (if available)

Paralogs for TMEM74 Gene

Paralogs for TMEM74 Gene

Selected SIMAP similar genes for TMEM74 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TMEM74: view

Variants for TMEM74 Gene

Sequence variations from dbSNP and Humsavar for TMEM74 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs7830993 -- 108,778,733(+) GATTA(A/C)AAGCA downstream-variant-500B
rs7831284 -- 108,778,919(+) AAATA(A/T)GGCAC downstream-variant-500B
rs7845404 -- 108,780,359(+) GAAGA(C/T)CAAAA utr-variant-3-prime
rs7845796 -- 108,780,474(+) GCTCA(A/G)TCACT utr-variant-3-prime
rs10955496 -- 108,780,785(+) TTCCT(C/G)TAAAC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TMEM74 Gene

Variant ID Type Subtype PubMed ID
nsv831420 CNV Gain 17160897
nsv891269 CNV Gain 21882294

Relevant External Links for TMEM74 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM74 Gene

Disorders for TMEM74 Gene

No disorders were found for TMEM74 Gene.

No data available for UniProtKB/Swiss-Prot for TMEM74 Gene

Publications for TMEM74 Gene

  1. TMEM74, a lysosome and autophagosome protein, regulates autophagy. (PMID: 18294959) Yu C. … Wang L. (Biochem. Biophys. Res. Commun. 2008) 3 4 23
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3

Products for TMEM74 Gene

  • antibodies-online peptides for TMEM74
  • antibodies-online antibodies for TMEM74
  • antibodies-online kits for TMEM74

Sources for TMEM74 Gene

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