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Aliases for TMEM74 Gene

Aliases for TMEM74 Gene

  • Transmembrane Protein 74 2 3 5
  • NET36 3

External Ids for TMEM74 Gene

Previous GeneCards Identifiers for TMEM74 Gene

  • GC08M109865
  • GC08M105116
  • GC08M109619

Summaries for TMEM74 Gene

GeneCards Summary for TMEM74 Gene

TMEM74 (Transmembrane Protein 74) is a Protein Coding gene. Diseases associated with TMEM74 include Fuchs' Endothelial Dystrophy. An important paralog of this gene is TMEM74B.

UniProtKB/Swiss-Prot for TMEM74 Gene

  • Plays an essential role in autophagy. TMEM74-induced autophagy may involve PI3K signal transduction.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM74 Gene

Genomics for TMEM74 Gene

Regulatory Elements for TMEM74 Gene

Enhancers for TMEM74 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08G108744 0.4 ENCODE 25.2 +42.9 42906 1.0 CREB1 TMEM74 GC08P108729 GC08P108730 LOC102723368
GH08G108246 1.1 ENCODE 4.3 +539.7 539707 3.3 HDGF PKNOX1 CREB3L1 ARNT WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 AURKBPS1 TMEM74 ENSG00000253754 GC08M108244
GH08G108786 0.8 ENCODE 4.9 +0.3 339 1.0 TBP ZNF76 GLIS2 EGR1 ZNF366 SCRT2 ZNF143 THAP11 SP3 SMAD5 TMEM74 PIR34407
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM74 on UCSC Golden Path with GeneCards custom track

Promoters for TMEM74 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000228762 215 1200 TBP ZNF76 GLIS2 EGR1 ZNF366 SCRT2 ZNF143 THAP11 SP3 SMAD5

Genomic Location for TMEM74 Gene

Chromosome:
8
Start:
108,606,850 bp from pter
End:
108,787,615 bp from pter
Size:
180,766 bases
Orientation:
Minus strand

Genomic View for TMEM74 Gene

Genes around TMEM74 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM74 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM74 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM74 Gene

Proteins for TMEM74 Gene

  • Protein details for TMEM74 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96NL1-TMM74_HUMAN
    Recommended name:
    Transmembrane protein 74
    Protein Accession:
    Q96NL1

    Protein attributes for TMEM74 Gene

    Size:
    305 amino acids
    Molecular mass:
    33338 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM74 Gene

Post-translational modifications for TMEM74 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM74 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM74 Gene

Domains & Families for TMEM74 Gene

Protein Domains for TMEM74 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM74 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96NL1

UniProtKB/Swiss-Prot:

TMM74_HUMAN :
  • Belongs to the TMEM74 family.
Family:
  • Belongs to the TMEM74 family.
genes like me logo Genes that share domains with TMEM74: view

No data available for Gene Families for TMEM74 Gene

Function for TMEM74 Gene

Molecular function for TMEM74 Gene

UniProtKB/Swiss-Prot Function:
Plays an essential role in autophagy. TMEM74-induced autophagy may involve PI3K signal transduction.

Gene Ontology (GO) - Molecular Function for TMEM74 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TMEM74: view
genes like me logo Genes that share phenotypes with TMEM74: view

Animal Model Products

CRISPR Products

miRNA for TMEM74 Gene

miRTarBase miRNAs that target TMEM74

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM74 Gene

Localization for TMEM74 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM74 Gene

Lysosome membrane; Multi-pass membrane protein. Cytoplasmic vesicle, autophagosome membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM74 gene
Compartment Confidence
lysosome 4
plasma membrane 3
peroxisome 1
cytosol 1

Gene Ontology (GO) - Cellular Components for TMEM74 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000421 autophagosome membrane IEA --
GO:0005764 lysosome IEA --
GO:0005765 lysosomal membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM74: view

Pathways & Interactions for TMEM74 Gene

SuperPathways for TMEM74 Gene

No Data Available

Interacting Proteins for TMEM74 Gene

Gene Ontology (GO) - Biological Process for TMEM74 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006914 autophagy IEA --
GO:0016236 macroautophagy IMP 18294959
genes like me logo Genes that share ontologies with TMEM74: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM74 Gene

Drugs & Compounds for TMEM74 Gene

No Compound Related Data Available

Transcripts for TMEM74 Gene

mRNA/cDNA for TMEM74 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMEM74 Gene

Transmembrane protein 74:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM74 Gene

No ASD Table

Relevant External Links for TMEM74 Gene

GeneLoc Exon Structure for
TMEM74
ECgene alternative splicing isoforms for
TMEM74

Expression for TMEM74 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM74 Gene

Protein differential expression in normal tissues from HIPED for TMEM74 Gene

This gene is overexpressed in Adipocyte (65.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TMEM74 Gene



Protein tissue co-expression partners for TMEM74 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TMEM74 Gene:

TMEM74

SOURCE GeneReport for Unigene cluster for TMEM74 Gene:

Hs.99439

mRNA Expression by UniProt/SwissProt for TMEM74 Gene:

Q96NL1-TMM74_HUMAN
Tissue specificity: Expressed in heart, lung, and placenta.

Evidence on tissue expression from TISSUES for TMEM74 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with TMEM74: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM74 Gene

Orthologs for TMEM74 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM74 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM74 34 35
  • 99.56 (n)
dog
(Canis familiaris)
Mammalia TMEM74 34 35
  • 86.01 (n)
cow
(Bos Taurus)
Mammalia TMEM74 34 35
  • 85.79 (n)
mouse
(Mus musculus)
Mammalia Tmem74 34 16 35
  • 81.42 (n)
rat
(Rattus norvegicus)
Mammalia Tmem74 34
  • 80.55 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM74 35
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM74 35
  • 45 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC100858101 34
  • 63.73 (n)
TMEM74 35
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM74 35
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem74 34
  • 52.89 (n)
Str.5572 34
zebrafish
(Danio rerio)
Actinopterygii LOC100331423 34
  • 56.28 (n)
TMEM74 (2 of 2) 35
  • 46 (a)
OneToMany
CABZ01021538.1 35
  • 40 (a)
OneToMany
Species where no ortholog for TMEM74 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM74 Gene

ENSEMBL:
Gene Tree for TMEM74 (if available)
TreeFam:
Gene Tree for TMEM74 (if available)

Paralogs for TMEM74 Gene

Paralogs for TMEM74 Gene

(1) SIMAP similar genes for TMEM74 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TMEM74: view

Variants for TMEM74 Gene

Sequence variations from dbSNP and Humsavar for TMEM74 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000010465 -- 108,698,710(+) TTCAT(A/T)CCCTC intron-variant
rs1000028390 -- 108,734,108(+) AAGAT(C/T)TGCCC intron-variant
rs1000044768 -- 108,776,338(+) AAATA(C/T)AAAAA intron-variant
rs1000065466 -- 108,741,809(+) CAGGA(A/G)CAAGA intron-variant
rs1000068837 -- 108,656,804(+) AGAAA(C/T)GTGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM74 Gene

Variant ID Type Subtype PubMed ID
nsv831420 CNV gain 17160897

Variation tolerance for TMEM74 Gene

Residual Variation Intolerance Score: 43.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.31; 26.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM74 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM74

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM74 Gene

Disorders for TMEM74 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TMEM74 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
fuchs' endothelial dystrophy
  • fced
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TMEM74

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM74
genes like me logo Genes that share disorders with TMEM74: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TMEM74 Gene

Publications for TMEM74 Gene

  1. TMEM74, a lysosome and autophagosome protein, regulates autophagy. (PMID: 18294959) Yu C. … Wang L. (Biochem. Biophys. Res. Commun. 2008) 3 4 22 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64

Products for TMEM74 Gene

Sources for TMEM74 Gene

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